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Betsy Kren

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Janeen H Trembley; Gretchen M Unger; Zygmunt Kazimierczuk; Vicci L Korman; Betsy T Kren; Lorenzo A Pinna; Diane K Tobolt; Khalil Ahmed
Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells.
Janeen H Trembley; Gretchen M Unger; Guixia Wang; Kashif A Ahmad; Vicci L Korman; Betsy T Kren; Joel W Slaton; Diane K Tobolt; Khalil Ahmed
Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α' subunits reduces orthotopic xenograft prostate tumors in mice.
Lucas Sjeklocha; Clifford J Steer; Yixin Chen; Meghan C Daly; Betsy T Kren
β-globin matrix attachment region improves stable genomic expression of the Sleeping Beauty transposon.

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2012: Janeen H Trembley; Gretchen M Unger; Zygmunt Kazimierczuk; Vicci L Korman; Betsy T Kren; Lorenzo A Pinna; Diane K Tobolt; Khalil Ahmed
Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells.
Cancer letters 2012;315(1):48-58.
2011: Janeen H Trembley; Gretchen M Unger; Guixia Wang; Kashif A Ahmad; Vicci L Korman; Betsy T Kren; Joel W Slaton; Diane K Tobolt; Khalil Ahmed
Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α' subunits reduces orthotopic xenograft prostate tumors in mice.
Molecular and cellular biochemistry 2011;356(1-2):21-35.
2011: Lucas Sjeklocha; Clifford J Steer; Yixin Chen; Meghan C Daly; Betsy T Kren
β-globin matrix attachment region improves stable genomic expression of the Sleeping Beauty transposon.
Journal of cellular biochemistry 2011;112(9):2361-75.
2011: Jingmin Shu; Jeffrey H Albrecht; Eric A Hanse; Betsy T Kren; Bingshan Li; Lihua Li; Michael X Min; Subbaya Subramanian; Phillip Y-P Wong; Zhilian Xia; Yan Zeng; Clifford J Steer
Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration.
Hepatology (Baltimore, Md.) 2011;54(2):609-19.
2010: Rui E Castro; Duarte M S Ferreira; Xiaoxiao Zhang; Pedro Borralho; Aaron L Sarver; Yan Zeng; Clifford J Steer; Betsy T Kren; Cecília M P Rodrigues
Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(4):G887-97.
2010: Janeen H Trembley; Zhong Chen; Gretchen Unger; Joel W Slaton; Betsy T Kren; Carter Van Waes; Khalil Ahmed
Emergence of protein kinase CK2 as a key target in cancer therapy.
BioFactors (Oxford, England) 2010;36(3):187-95.
2010: Jianhui Zhu; Chang Won Park; Lucas Sjeklocha; Betsy T Kren; Clifford J Steer
High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene.
Biochemistry 2010;49(7):1507-21.
2009: Betsy T Kren; Phillip Y-P Wong; Akira Shiota; Xiaoxiao Zhang; Yan Zeng; Clifford J Steer
Polysome trafficking of transcripts and microRNAs in regenerating liver after partial hepatectomy.
American journal of physiology. Gastrointestinal and liver physiology 2009;297(6):G1181-92.
2009: Pedro M Borralho; Betsy T Kren; Rui E Castro; Isabel B Moreira da Silva; Clifford J Steer; Cecília M P Rodrigues
MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells.
The FEBS journal 2009;276(22):6689-700.
2009: Xia Wang; Debi P Sarkar; Prashant Mani; Clifford J Steer; Yong Chen; Chandan Guha; Voshavar Chandrasekhar; Arabinda Chaudhuri; Namita Roy-Chowdhury; Betsy T Kren; Jayanta Roy-Chowdhury
Long-term reduction of jaundice in Gunn rats by nonviral liver-targeted delivery of Sleeping Beauty transposon.
Hepatology (Baltimore, Md.) 2009;50(3):815-24.
2009: Betsy T Kren; Gretchen M Unger; Lucas Sjeklocha; Alycia A Trossen; Vicci Korman; Brenda M Diethelm-Okita; Mark T Reding; Clifford J Steer
Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice.
The Journal of clinical investigation 2009;119(7):2086-99.
2009: Julie M Cunningham; Ann L Oberg; Pedro Borralho; Betsy T Kren; Amy J French; Liang Wang; Brian M Bot; Bruce W Morlan; Kevin A T Silverstein; Rod Staggs; Yan Zeng; Anne-Francoise Lamblin; Christopher A Hilker; Jian-Bing Fan; Clifford J Steer; Stephen N Thibodeau
Evaluation of a new high-dimensional miRNA profiling platform.
BMC medical genomics 2009;2():57.
2009: Betsy T Kren; Phillip Y-P Wong; Aaron Sarver; Xiaoxiao Zhang; Yan Zeng; Clifford J Steer
MicroRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis.
RNA biology 2009;6(1):65-72.
2007: Rui E Castro; Joana D Amaral; Susana Solá; Betsy T Kren; Clifford J Steer; Cecília M P Rodrigues
Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(1):G327-34.
2007: Jianhui Zhu; Betsy T Kren; Chang Won Park; Rasim Bilgim; Phillip Y-P Wong; Clifford J Steer
Erythroid-specific expression of beta-globin by the sleeping beauty transposon for Sickle cell disease.
Biochemistry 2007;46(23):6844-58.
2007: Betsy T Kren; Wenxan Yin; Nigel S Key; Robert P Hebbel; Clifford J Steer
Blood outgrowth endothelial cells as a vehicle for transgene expression of hepatocyte-secreted proteins via Sleeping Beauty.
Endothelium : journal of endothelial cell research 2007;14(2):97-104.
2007: Andrew Rivard; Clifford J Steer; Betsy T Kren; Cecília M P Rodrigues; Rui E Castro; Richard W Bianco; Walter C Low
Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat.
The American journal of Chinese medicine 2007;35(2):279-95.
2006: Chang Won Park; Jeongmin Park; Betsy T Kren; Clifford J Steer
Sleeping Beauty transposition in the mouse genome is associated with changes in DNA methylation at the site of insertion.
Genomics 2006;88(2):204-13.
2005: Susana Solá; Joana D Amaral; Rui E Castro; Rita M Ramalho; Pedro Borralho; Betsy T Kren; Hirotoshi Tanaka; Clifford J Steer; Cecília M P Rodrigues
Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes.
Hepatology (Baltimore, Md.) 2005;42(4):925-34.
2005: Wenxuan Yin; Betsy T Kren; Clifford J Steer
Site-specific base changes in the coding or promoter region of the human beta- and gamma-globin genes by single-stranded oligonucleotides.
The Biochemical journal 2005;390(Pt 1):253-61.
2005: Chang Won Park; Betsy T Kren; David Largaespada; Clifford J Steer
DNA methylation of Sleeping Beauty with transposition into the mouse genome.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(8):763-76.
2005: Rui E Castro; Susana Solá; Xiaoming Ma; Rita M Ramalho; Betsy T Kren; Clifford J Steer; Cecília M P Rodrigues
A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid.
Journal of hepatology 2005;42(6):897-906.
2005: Paul W Wacnik; Christine M Baker; Michael J Herron; Betsy T Kren; Bruce R Blazar; George L Wilcox; Maria Hordinsky; Alvin J Beitz; Marna E Ericson
Tumor-induced mechanical hyperalgesia involves CGRP receptors and altered innervation and vascularization of DsRed2 fluorescent hindpaw tumors.
Pain 2005;115(1-2):95-106.
2005: Zongyu J Chen; Betsy T Kren; Phillip Y-P Wong; Walter C Low; Clifford J Steer
Sleeping Beauty-mediated down-regulation of huntingtin expression by RNA interference.
Biochemical and biophysical research communications 2005;329(2):646-52.
2004: Chang Won Park; Zongyu Chen; Betsy T Kren; Clifford J Steer
Double-stranded siRNA targeted to the huntingtin gene does not induce DNA methylation.
Biochemical and biophysical research communications 2004;323(1):275-80.
2004: Susana Solá; Rui E Castro; Betsy T Kren; Clifford J Steer; Cecília M P Rodrigues
Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes.
Biochemistry 2004;43(26):8429-38.
2004: Martin G Sauer; Marna E Ericson; Brenda J Weigel; Michael J Herron; Angela Panoskaltsis-Mortari; Betsy T Kren; Bruce L Levine; Jonathan S Serody; Carl H June; Patricia A Taylor; Bruce R Blazar
A novel system for simultaneous in vivo tracking and biological assessment of leukemia cells and ex vivo generated leukemia-reactive cytotoxic T cells.
Cancer research 2004;64(11):3914-21.
2004: Clifford J Steer; Betsy T Kren
Gene therapy and CVD: how near are we?
Atherosclerosis. Supplements 2004;5(2):33-42.
2003: Susana Sola; Xiaoming Ma; Rui E Castro; Betsy T Kren; Clifford J Steer; Cecília M P Rodrigues
Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta1-induced apoptosis of rat hepatocytes.
The Journal of biological chemistry 2003;278(49):48831-8.
2003: Betsy T Kren; Phillip Y Wong; Clifford J Steer
Short, single-stranded oligonucleotides mediate targeted nucleotide conversion using extracts from isolated liver mitochondria.
DNA repair 2003;2(5):531-46.
2002: Betsy T Kren; Namita Roy-Chowdhury; Jayanta Roy-Chowdhury; Clifford J Steer
Gene therapy as an alternative to liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2002;8(12):1089-108.
2002: Betsy T Kren; Clifford J Steer
The application of DNA repair vectors to gene therapy.
Current opinion in biotechnology 2002;13(5):473-81.
2002: Guangsheng Fan; Xiaoming Ma; Betsy T Kren; Clifford J Steer
Unbound E2F modulates TGF-beta1-induced apoptosis in HuH-7 cells.
Journal of cell science 2002;115(Pt 15):3181-91.
2002: Betsy T Kren; Z Chen; R Felsheim; Namita Roy-Chowdhury; Jayanta Roy-Chowdhury; Clifford J Steer
Modification of hepatic genomic DNA using RNA/DNA oligonucleotides.
Gene therapy 2002;9(11):686-90.
2002: Paul Richardson; Christian Thoma; Betsy T Kren; Clifford J Steer
Strategies for hepatic gene correction.
Journal of drug targeting 2002;10(2):133-41.
2002: Paul Richardso; Betsy T Kren; Clifford J Steer
In vivo application of non-viral vectors to the liver.
Journal of drug targeting 2002;10(2):123-31.
2002: Paul D Richardson; Betsy T Kren; Clifford J Steer
Gene repair in the new age of gene therapy.
Hepatology (Baltimore, Md.) 2002;35(3):512-8.
2002: Paul D Richardson; Lance B Augustin; Betsy T Kren; Clifford J Steer
Gene repair and transposon-mediated gene therapy.
Stem cells (Dayton, Ohio) 2002;20(2):105-18.
2002: Betsy T Kren; Paramita Bandyopadhyay; Namita Roy-Chowdhury; Jayanta Roy-Chowdhury; Clifford J Steer
Oligonucleotide-mediated site-directed gene repair.
Methods in enzymology 2002;346():14-35.
2001: C Dirk Keene; Cecília M P Rodrigues; T Eich; Cheryle Linehan-Stieers; A Abt; Betsy T Kren; Clifford J Steer; Walter C Low
A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease.
Experimental neurology 2001;171(2):351-60.
2001: Paul D Richardson; Betsy T Kren; Clifford J Steer
Targeted gene correction strategies.
Current opinion in molecular therapeutics 2001;3(4):327-37.
2001: Z Chen; R Felsheim; P Wong; Lance B Augustin; R Metz; Betsy T Kren; Clifford J Steer
Mitochondria isolated from liver contain the essential factors required for RNA/DNA oligonucleotide-targeted gene repair.
Biochemical and biophysical research communications 2001;285(2):188-94.
2001: Betsy T Kren; Cecília M P Rodrigues; K D Setchell; Clifford J Steer
Modulation of steady-state messenger RNA levels in the regenerating rat liver with bile acid feeding.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2001;7(4):321-34.
2000: Cecília M P Rodrigues; C L Stieers; C Dirk Keene; X Ma; Betsy T Kren; Walter C Low; Clifford J Steer
Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition.
Journal of neurochemistry 2000;75(6):2368-79.
2000: J H Trembley; Z Chen; C M Rodrigues; Betsy T Kren; Clifford J Steer
Genomic organization and promoter characterization of the rat cyclin B1 gene.
Gene 2000;255(1):93-104.
1999: Cecília M P Rodrigues; X Ma; Cheryle Linehan-Stieers; G Fan; Betsy T Kren; Clifford J Steer
Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation.
Cell death and differentiation 1999;6(9):842-54.
1999: Betsy T Kren; Bhupesh Parashar; Paramita Bandyopadhyay; Namita Roy-Chowdhury; Jayanta Roy-Chowdhury; Clifford J Steer
Correction of the UDP-glucuronosyltransferase gene defect in the gunn rat model of crigler-najjar syndrome type I with a chimeric oligonucleotide.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10349-54.
1999: Paramita Bandyopadhyay; X Ma; Cheryle Linehan-Stieers; Betsy T Kren; Clifford J Steer
Nucleotide exchange in genomic DNA of rat hepatocytes using RNA/DNA oligonucleotides. Targeted delivery of liposomes and polyethyleneimine to the asialoglycoprotein receptor.
The Journal of biological chemistry 1999;274(15):10163-72.
1999: Betsy T Kren; R Metz; R Kumar; Clifford J Steer
Gene repair using chimeric RNA/DNA oligonucleotides.
Seminars in liver disease 1999;19(1):93-104.
1998: Paramita Bandyopadhyay; Betsy T Kren; X Ma; Clifford J Steer
Enhanced gene transfer into HuH-7 cells and primary rat hepatocytes using targeted liposomes and polyethylenimine.
BioTechniques 1998;25(2):282-4, 286-92.
1998: Cecília M P Rodrigues; G Fan; X Ma; Betsy T Kren; Clifford J Steer
A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.
The Journal of clinical investigation 1998;101(12):2790-9.
1998: Cecília M P Rodrigues; G Fan; P Y Wong; Betsy T Kren; Clifford J Steer
Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production.
Molecular medicine (Cambridge, Mass.) 1998;4(3):165-78.
1998: Betsy T Kren; Paramita Bandyopadhyay; Clifford J Steer
In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides.
Nature medicine 1998;4(3):285-90.
1998: G Fan; Betsy T Kren; Clifford J Steer
Regulation of apoptosis-associated genes in the regenerating liver.
Seminars in liver disease 1998;18(2):123-40.
1997: Betsy T Kren; J H Trembley; G Fan; Clifford J Steer
Molecular regulation of liver regeneration.
Annals of the New York Academy of Sciences 1997;831():361-81.
1997: Guorong Xu; Gerald Salen; Sarah Shefer; Stephen G Tint; Betsy T Kren; Lien B Nguyen; Clifford J Steer; TS Chen; L Salen; D Greenblatt
Increased bile acid pool inhibits cholesterol 7 alpha-hydroxylase in cholesterol-fed rabbits.
Gastroenterology 1997;113(6):1958-65.
1997: G Fan; X Ma; Betsy T Kren; M Rice; Eric B Kmiec; Clifford J Steer
A novel link between REC2, a DNA recombinase, the retinoblastoma protein, and apoptosis.
The Journal of biological chemistry 1997;272(31):19413-7.
1997: Betsy T Kren; AC Cole-Strauss; Eric B Kmiec; Clifford J Steer
Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide.
Hepatology (Baltimore, Md.) 1997;25(6):1462-8.
1997: Gerald Y Minuk; Betsy T Kren; R Xu; X Zhang; Frank J Burczynski; N P Mulrooney; G Fan; Yuewen Gong; Clifford J Steer
The effect of changes in hepatocyte membrane potential on immediate-early proto-oncogene expression following partial hepatectomy in rats.
Hepatology (Baltimore, Md.) 1997;25(5):1123-7.
1997: PF Leeds; Betsy T Kren; Joan M Boylan; N A Betz; Clifford J Steer; Philip A Gruppuso; Jeff Ross
Developmental regulation of CRD-BP, an RNA-binding protein that stabilizes c-myc mRNA in vitro.
Oncogene 1997;14(11):1279-86.
1996: Betsy T Kren; J H Trembley; S Krajewski; timothy wayne behrens; J C Reed; Clifford J Steer
Modulation of apoptosis-associated genes bcl-2, bcl-x, and bax during rat liver regeneration.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(12):1633-42.
1996: J H Trembley; J O Ebbert; Betsy T Kren; Clifford J Steer
Differential regulation of cyclin B1 RNA and protein expression during hepatocyte growth in vivo.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(7):903-16.
1996: G Fan; X Ma; Betsy T Kren; Clifford J Steer
The retinoblastoma gene product inhibits TGF-beta1 induced apoptosis in primary rat hepatocytes and human HuH-7 hepatoma cells.
Oncogene 1996;12(9):1909-19.
1996: Betsy T Kren; J H Trembley; Clifford J Steer
Alterations in mRNA stability during rat liver regeneration.
The American journal of physiology 1996;270(5 Pt 1):G763-77.
1996: Betsy T Kren; Clifford J Steer
Posttranscriptional regulation of gene expression in liver regeneration: role of mRNA stability.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(5):559-73.
1996: Cecília M P Rodrigues; Betsy T Kren; Clifford J Steer; Kenneth D R Setchell
Formation of delta 22-bile acids in rats is not gender specific and occurs in the peroxisome.
Journal of lipid research 1996;37(3):540-50.
1995: Betsy T Kren; Cecília M P Rodrigues; Kenneth D R Setchell; Clifford J Steer
Posttranscriptional regulation of mRNA levels in rat liver associated with deoxycholic acid feeding.
The American journal of physiology 1995;269(6 Pt 1):G961-73.
1995: Cecília M P Rodrigues; Betsy T Kren; Clifford J Steer; Kenneth D R Setchell
The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation.
Gastroenterology 1995;109(6):1835-44.
1995: G Fan; R Xu; M W Wessendorf; X Ma; Betsy T Kren; Clifford J Steer
Modulation of retinoblastoma and retinoblastoma-related proteins in regenerating rat liver and primary hepatocytes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(11):1463-76.
1995: Sarah Shefer; Betsy T Kren; G Salen; Clifford J Steer; Lien B Nguyen; T Chen; Stephen G Tint; A K Batta
Regulation of bile acid synthesis by deoxycholic acid in the rat: different effects on cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase.
Hepatology (Baltimore, Md.) 1995;22(4 Pt 1):1215-21.
1995: Cecília M P Rodrigues; Betsy T Kren; Clifford J Steer; Kenneth D R Setchell
Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate.
Gastroenterology 1995;109(2):564-72.
1995: Kenneth D R Setchell; H Yamashita; Cecília M P Rodrigues; N C O'Connell; Betsy T Kren; Clifford J Steer
delta 22-Ursodeoxycholic acid, a unique metabolite of administered ursodeoxycholic acid in rats, indicating partial beta-oxidation as a major pathway for bile acid metabolism.
Biochemistry 1995;34(13):4169-78.
1994: Jeffrey H Albrecht; U Muller-Eberhard; Betsy T Kren; Clifford J Steer
Influence of transcriptional regulation and mRNA stability on hemopexin gene expression in regenerating liver.
Archives of biochemistry and biophysics 1994;314(1):229-33.
1994: Jeffrey H Albrecht; J S Hoffman; Betsy T Kren; Clifford J Steer
Changes in cell cycle-associated gene expression in a model of impaired liver regeneration.
FEBS letters 1994;347(2-3):157-62.
1994: Betsy T Kren; A L Teel; Clifford J Steer
Transcriptional rate and steady-state changes of retinoblastoma mRNA in regenerating rat liver.
Hepatology (Baltimore, Md.) 1994;19(5):1214-22.
1994: J H Trembley; Betsy T Kren; Clifford J Steer
Posttranscriptional regulation of cyclin B messenger RNA expression in the regenerating rat liver.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(1):99-108.
1993: Jeffrey H Albrecht; J S Hoffman; Betsy T Kren; Clifford J Steer
Cyclin and cyclin-dependent kinase 1 mRNA expression in models of regenerating liver and human liver diseases.
The American journal of physiology 1993;265(5 Pt 1):G857-64.
1993: Betsy T Kren; Nalin M Kumar; S Q Wang; Norton B Gilula; Clifford J Steer
Differential regulation of multiple gap junction transcripts and proteins during rat liver regeneration.
The Journal of cell biology 1993;123(3):707-18.
1991: A M Diehl; H C Bisgaard; Betsy T Kren; Clifford J Steer
Ethanol interferes with regeneration-associated changes in biotransforming enzymes: a potential mechanism underlying ethanol's carcinogenicity?
Hepatology (Baltimore, Md.) 1991;13(4):722-7.