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Arthur Krieg

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Joel N Kline; Arthur M Krieg
Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy.
Urvashi Bhan; Glenda Trujillo; Kenneth Lyn-Kew; Michael W Newstead; Xianying Zeng; Cory M Hogaboam; Arthur M Krieg; Theodore J Standiford
Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila.
Curtis L Cooper; Navneet K Ahluwalia; Susan M Efler; Jörg Vollmer; Arthur M Krieg; Heather L Davis
Immunostimulatory effects of three classes of CpG oligodeoxynucleotides on PBMC from HCV chronic carriers.

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All Publications

2008: Joel N Kline; Arthur M Krieg
Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy.
Drug news & perspectives 2008;21(8):434-9.
2008: Urvashi Bhan; Glenda Trujillo; Kenneth Lyn-Kew; Michael W Newstead; Xianying Zeng; Cory M Hogaboam; Arthur M Krieg; Theodore J Standiford
Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila.
Infection and immunity 2008;76(7):2895-904.
2008: Curtis L Cooper; Navneet K Ahluwalia; Susan M Efler; Jörg Vollmer; Arthur M Krieg; Heather L Davis
Immunostimulatory effects of three classes of CpG oligodeoxynucleotides on PBMC from HCV chronic carriers.
Journal of immune based therapies and vaccines 2008;6():3.
2007: John P Leonard; Brian K Link; Christos Emmanouilides; Stephanie A Gregory; Daniel Weisdorf; Jeffrey Andrey; John Hainsworth; Joseph A Sparano; Donald E Tsai; Sandra Horning; Arthur M Krieg; George J Weiner
Phase I trial of toll-like receptor 9 agonist PF-3512676 with and following rituximab in patients with recurrent indolent and aggressive non Hodgkin's lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(20):6168-74.
2007: Urvashi Bhan; Nicholas W Lukacs; John Osterholzer; Michael W Newstead; Xianying Zeng; Thomas A Moore; Tracy R McMillan; Arthur M Krieg; Shizuo Akira; Theodore J Standiford
TLR9 is required for protective innate immunity in Gram-negative bacterial pneumonia: role of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3937-46.
2007: Alain P Vicari; Tess Schmalbach; Julie Lekstrom-Himes; Mary Lou Morris; Mohammed J Al Adhami; Chantal Laframboise; Philip Leese; Arthur M Krieg; Susan M Efler; Heather L Davis
Safety, pharmacokinetics and immune effects in normal volunteers of CPG 10101 (ACTILON), an investigational synthetic toll-like receptor 9 agonist.
Antiviral therapy 2007;12(5):741-51.
2006: Brian K Link; Zuhair K Ballas; Daniel Weisdorf; James E Wooldridge; Aaron D Bossler; Mary Shannon; Wendy L Rasmussen; Arthur M Krieg; George J Weiner
Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2006;29(5):558-68.
2006: David M Lubaroff; Dev Karan; Michael P Andrews; Anna Acosta; Chadi Abouassaly; Madeva Sharma; Arthur M Krieg
Decreased cytotoxic T cell activity generated by co-administration of PSA vaccine and CpG ODN is associated with increased tumor protection in a mouse model of prostate cancer.
Vaccine 2006;24(35-36):6155-62.
2006: Kensuke Ohashi; Gen Kobayashi; Sandy Fang; Xiaoyan Zhu; Scott J Antonia; Arthur M Krieg; Anthony D Sandler
Surgical excision combined with autologous whole tumor cell vaccination is an effective therapy for murine neuroblastoma.
Journal of pediatric surgery 2006;41(8):1361-8.
2005: John E Butler; David H Francis; Jessica Freeling; Patrick Weber; Arthur M Krieg
Antibody repertoire development in fetal and neonatal piglets. IX. Three pathogen-associated molecular patterns act synergistically to allow germfree piglets to respond to type 2 thymus-independent and thymus-dependent antigens.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(10):6772-85.
2005: Curtis L Cooper; Heather L Davis; Jonathan B Angel; Mary Lou Morris; Sue M Elfer; Isabelle Seguin; Arthur M Krieg; William Cameron
CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults.
AIDS (London, England) 2005;19(14):1473-9.
2004: Curtis L Cooper; Heather L Davis; Mary Lou Morris; Susan M Efler; M Al Adhami; Arthur M Krieg; William Cameron; J Heathcote
CPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: a double-blind phase I/II study.
Journal of clinical immunology 2004;24(6):693-701.
2004: Arthur M Krieg; Susan M Efler; Michael Wittpoth; Mohammed J Al Adhami; Heather L Davis
Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2004;27(6):460-71.
2004: Jane C Deng; Thomas A Moore; Michael W Newstead; Xianying Zeng; Arthur M Krieg; Theodore J Standiford
CpG oligodeoxynucleotides stimulate protective innate immunity against pulmonary Klebsiella infection.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5148-55.
2004: Curtis L Cooper; Heather L Davis; Mary Lou Morris; Susan M Efler; Arthur M Krieg; Y Li; C Laframboise; Mohammed J Al Adhami; Yasmin Khaliq; Isabelle Seguin; William Cameron
Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine.
Vaccine 2004;22(23-24):3136-43.
2004: Yiqiang Wang; Arthur M Krieg
Induction of autoantibody production but not autoimmune disease in HEL transgenic mice vaccinated with HEL in combination with CpG or control oligodeoxynucleotides.
Vaccine 2004;22(20):2641-50.
2004: Xiaoyan Zhu; Ruth A Coleman; Carol Alber; Zuhair K Ballas; Thomas J Waldschmidt; Nancy B Ray; Arthur M Krieg; Robert T Cook
Chronic ethanol ingestion by mice increases expression of CD80 and CD86 by activated macrophages.
Alcohol (Fayetteville, N.Y.) 2004;32(2):91-100.
2003: Nancy B Ray; Arthur M Krieg
Oral pretreatment of mice with CpG DNA reduces susceptibility to oral or intraperitoneal challenge with virulent Listeria monocytogenes.
Infection and immunity 2003;71(8):4398-404.
2003: Arthur M Krieg
CpG motifs: the active ingredient in bacterial extracts?
Nature medicine 2003;9(7):831-5.
2003: Ae-Kyung Yi; Jae-Geun Yoon; Arthur M Krieg
Convergence of CpG DNA- and BCR-mediated signals at the c-Jun N-terminal kinase and NF-kappaB activation pathways: regulation by mitogen-activated protein kinases.
International immunology 2003;15(5):577-91.
2003: Sue E Blackwell; Arthur M Krieg
CpG-A-induced monocyte IFN-gamma-inducible protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-alpha.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4061-8.
2003: Yiqiang Wang; Arthur M Krieg
Synergy between CpG- or non-CpG DNA and specific antigen for B cell activation.
International immunology 2003;15(2):223-31.
2003: Anthony D Sandler; Hiroshi Chihara; Gen Kobayashi; Xiaoyan Zhu; Michal A Miller; David L Scott; Arthur M Krieg
CpG oligonucleotides enhance the tumor antigen-specific immune response of a granulocyte macrophage colony-stimulating factor-based vaccine strategy in neuroblastoma.
Cancer research 2003;63(2):394-9.
2003: Arthur M Krieg; Piotr Guga; Wojciech J Stec
P-chirality-dependent immune activation by phosphorothioate CpG oligodeoxynucleotides.
Oligonucleotides 2003;13(6):491-9.
2003: Arthur M Krieg
CpG DNA: trigger of sepsis, mediator of protection, or both?
Scandinavian journal of infectious diseases 2003;35(9):653-9.
2003: Petar Lenert; Ae-Kyung Yi; Arthur M Krieg; Laura L Stunz; Robert F Ashman
Inhibitory oligonucleotides block the induction of AP-1 transcription factor by stimulatory CpG oligonucleotides in B cells.
Antisense & nucleic acid drug development 2003;13(3):143-50.
2002: Jeffrey D Kirsch; Ae-Kyung Yi; Douglas R Spitz; Arthur M Krieg
Accumulation of glutathione disulfide mediates NF-kappaB activation during immune stimulation with CpG DNA.
Antisense & nucleic acid drug development 2002;12(5):327-40.
2002: Annette J Schlueter; Arthur M Krieg; Peter De Vries; Xiang Li
B cells express Ly-6C in a Th1 but not Th2 cytokine environment.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(7):799-806.
2002: Weiyin Shen; Marianella Waldschmidt; Xiuqin Zhao; Timothy Ratliff; Arthur M Krieg
Antitumor mechanisms of oligodeoxynucleotides with CpG and polyG motifs in murine prostate cancer cells: decrease of NF-kappaB and AP-1 binding activities and induction of apoptosis.
Antisense & nucleic acid drug development 2002;12(3):155-64.
2002: Laura L Stunz; Petar Lenert; David Peckham; Ae-Kyung Yi; Sokol Haxhinasto; Ming Chang; Arthur M Krieg; Robert F Ashman
Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells.
European journal of immunology 2002;32(5):1212-22.
2002: Ae-Kyung Yi; Jae-Geun Yoon; Seon-Ju Yeo; Soon-Cheol Hong; B Keith English; Arthur M Krieg
Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4711-20.
2002: Arthur M Krieg
CpG motifs in bacterial DNA and their immune effects.
Annual review of immunology 2002;20():709-60.
2001: Simon Rothenfusser; Veit Hornung; Anne Krug; Andreas Towarowski; Arthur M Krieg; Stefan Endres; Gunther Hartmann
Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta.
European journal of immunology 2001;31(12):3525-34.
2001: Ae-Kyung Yi; Jae-Geun Yoon; Soon-Cheol Hong; TW Redford; Arthur M Krieg
Lipopolysaccharide and CpG DNA synergize for tumor necrosis factor-alpha production through activation of NF-kappaB.
International immunology 2001;13(11):1391-404.
2001: Zuhair K Ballas; Arthur M Krieg; Thomas L Warren; Wendy L Rasmussen; Heather L Davis; Marianella Waldschmidt; George J Weiner
Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):4878-86.
2001: Anne Krug; Andreas Towarowski; Stefanie Britsch; Simon Rothenfusser; Veit Hornung; Robert Bals; Thomas Giese; Hartmut Engelmann; Stefan Endres; Arthur M Krieg; Gunther Hartmann
Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12.
European journal of immunology 2001;31(10):3026-37.
2001: Petar Lenert; Laura L Stunz; Ae-Kyung Yi; Arthur M Krieg; Robert F Ashman
CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kappaB activation.
Antisense & nucleic acid drug development 2001;11(4):247-56.
2001: Annette J Schlueter; Arthur M Krieg; Peter De Vries; Xiang Li
Type I interferon is the primary regulator of inducible Ly-6C expression on T cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001;21(8):621-9.
2001: Y Chen; Juan Zhang; S A Moore; Zuhair K Ballas; J P Portanova; Arthur M Krieg; Daniel J Berg
CpG DNA induces cyclooxygenase-2 expression and prostaglandin production.
International immunology 2001;13(8):1013-20.
2001: Anne Krug; Simon Rothenfusser; Veit Hornung; Bernd Jahrsdörfer; S Blackwell; Zuhair K Ballas; Stefan Endres; Arthur M Krieg; Gunther Hartmann
Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells.
European journal of immunology 2001;31(7):2154-63.
2001: Y Chen; Petar Lenert; Risini D Weeratna; Michael J McCluskie; T Wu; Heather L Davis; Arthur M Krieg
Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs.
Gene therapy 2001;8(13):1024-32.
2001: Arthur M Krieg
From bugs to drugs: therapeutic immunomodulation with oligodeoxynucleotides containing CpG sequences from bacterial DNA.
Antisense & nucleic acid drug development 2001;11(3):181-8.
2001: Bernd Jahrsdörfer; Gunther Hartmann; Emilian Racila; W Jackson; Lars Mühlenhoff; Gerold Meinhardt; Stefan Endres; Brian K Link; Arthur M Krieg; George J Weiner
CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens.
Journal of leukocyte biology 2001;69(1):81-8.
2001: Jiri Kovarik; Paola Bozzotti; Chantal Tougne; Heather L Davis; Paul-Henri Lambert; Arthur M Krieg; Claire-Anne Siegrist
Adjuvant effects of CpG oligodeoxynucleotides on responses against T-independent type 2 antigens.
Immunology 2001;102(1):67-76.
2000: C Brunner; Julia Seiderer; Angelika Schlamp; Martin Bidlingmaier; Andreas Eigler; Wolfgang Haimerl; Hans-Anton Lehr; Arthur M Krieg; Gunther Hartmann; Stefan Endres
Enhanced dendritic cell maturation by TNF-alpha or cytidine-phosphate-guanosine DNA drives T cell activation in vitro and therapeutic anti-tumor immune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6278-86.
2000: Thomas L Warren; SK Bhatia; A M Acosta; Christopher E Dahle; Timothy L Ratliff; Arthur M Krieg; George J Weiner
APC stimulated by CpG oligodeoxynucleotide enhance activation of MHC class I-restricted T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6244-51.
2000: Arthur M Krieg
Immune effects and mechanisms of action of CpG motifs.
Vaccine 2000;19(6):618-22.
2000: Arthur M Krieg; H Wagner
Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA.
Immunology today 2000;21(10):521-6.
2000: Arthur M Krieg
The role of CpG motifs in innate immunity.
Current opinion in immunology 2000;12(1):35-43.
2000: Gunther Hartmann; Risini D Weeratna; Zuhair K Ballas; Paul J Payette; Sue E Blackwell; I Suparto; Wendy L Rasmussen; Marianella Waldschmidt; D Sajuthi; Robert Purcell; Heather L Davis; Arthur M Krieg
Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1617-24.
2000: Gunther Hartmann; Arthur M Krieg
Mechanism and function of a newly identified CpG DNA motif in human primary B cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):944-53.
2000: Arthur M Krieg
Signal transduction induced by immunostimulatory CpG DNA.
Springer seminars in immunopathology 2000;22(1-2):97-105.
2000: Arthur M Krieg; A K Yi
Rescue of B cells from apoptosis by immune stimulatory CpG DNA.
Springer seminars in immunopathology 2000;22(1-2):55-61.
1999: Arthur M Krieg
Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides.
Biochimica et biophysica acta 1999;1489(1):107-16.
1999: Ae-Kyung Yi; David Peckham; Robert F Ashman; Arthur M Krieg
CpG DNA rescues B cells from apoptosis by activating NFkappaB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway.
International immunology 1999;11(12):2015-24.
1999: Joel N Kline; Arthur M Krieg; Thomas J Waldschmidt; Zuhair K Ballas; V Jain; Thomas R Businga
CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma.
The Journal of allergy and clinical immunology 1999;104(6):1258-64.
1999: Gunther Hartmann; George J Weiner; Arthur M Krieg
CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9305-10.
1999: David A Schwartz; Christine Wohlford-Lenane; Timothy J Quinn; Arthur M Krieg
Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):224-31.
1999: G Hartmann; Arthur M Krieg
CpG DNA and LPS induce distinct patterns of activation in human monocytes.
Gene therapy 1999;6(5):893-903.
1999: Jiri Kovarik; Paola Bozzotti; Laurie Love-Homan; Maria Pihlgren; Heather L Davis; Paul-Henri Lambert; Arthur M Krieg; Claire-Anne Siegrist
CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1611-7.
1998: H M Liu; S E Newbrough; SK Bhatia; Christopher E Dahle; Arthur M Krieg; George J Weiner
Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor.
Blood 1998;92(10):3730-6.
1998: Ae-Kyung Yi; Arthur M Krieg
Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4493-7.
1998: TW Redford; Ae-Kyung Yi; C T Ward; Arthur M Krieg
Cyclosporin A enhances IL-12 production by CpG motifs in bacterial DNA and synthetic oligodeoxynucleotides.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):3930-5.
1998: Arthur M Krieg; T Wu; Risini D Weeratna; Susan M Efler; Laurie Love-Homan; Linda Yang; Ae-Kyung Yi; D Short; Heather L Davis
Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12631-6.
1998: Arthur M Krieg; Laurie Love-Homan; Ae-Kyung Yi; John T Harty
CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2428-34.
1998: Ae-Kyung Yi; M Chang; David Peckham; Arthur M Krieg; Robert F Ashman
CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):5898-906.
1998: Ae-Kyung Yi; Rebecca Tuetken; TW Redford; Marianella Waldschmidt; J Kirsch; Arthur M Krieg
CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4755-61.
1998: Joel N Kline; Thomas J Waldschmidt; Thomas R Businga; J E Lemish; Joel V Weinstock; Peter S Thorne; Arthur M Krieg
Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(6):2555-9.
1998: Ae-Kyung Yi; Arthur M Krieg
CpG DNA rescue from anti-IgM-induced WEHI-231 B lymphoma apoptosis via modulation of I kappa B alpha and I kappa B beta and sustained activation of nuclear factor-kappa B/c-Rel.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(3):1240-5.
1998: Arthur M Krieg; Ae-Kyung Yi; J Schorr; Heather L Davis
The role of CpG dinucleotides in DNA vaccines.
Trends in microbiology 1998;6(1):23-7.
1997: M Anitescu; J H Chace; Rebecca Tuetken; Ae-Kyung Yi; Daniel J Berg; Arthur M Krieg; John S Cowdery
Interleukin-10 functions in vitro and in vivo to inhibit bacterial DNA-induced secretion of interleukin-12.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997;17(12):781-8.
1997: George J Weiner; H M Liu; James E Wooldridge; Christopher E Dahle; Arthur M Krieg
Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10833-7.
1997: J H Chace; N A Hooker; K L Mildenstein; Arthur M Krieg; John S Cowdery
Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12.
Clinical immunology and immunopathology 1997;84(2):185-93.
1997: David A Schwartz; Timothy J Quinn; Peter S Thorne; S Sayeed; Ae-Kyung Yi; Arthur M Krieg
CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract.
The Journal of clinical investigation 1997;100(1):68-73.
1997: James E Wooldridge; Zuhair K Ballas; Arthur M Krieg; George J Weiner
Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma.
Blood 1997;89(8):2994-8.
1997: Arthur M Krieg; S Matson; K Cheng; E Fisher; G A Koretzky; John G Koland
Identification of an oligodeoxynucleotide sequence motif that specifically inhibits phosphorylation by protein tyrosine kinases.
Antisense & nucleic acid drug development 1997;7(2):115-23.
1996: Ae-Kyung Yi; D M Klinman; T L Martin; S Matson; Arthur M Krieg
Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5394-402.
1996: Ae-Kyung Yi; Peter Hornbeck; D E Lafrenz; Arthur M Krieg
CpG DNA rescue of murine B lymphoma cells from anti-IgM-induced growth arrest and programmed cell death is associated with increased expression of c-myc and bcl-xL.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):4918-25.
1996: Zuhair K Ballas; W L Rasmussen; Arthur M Krieg
Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):1840-5.
1996: Arthur M Krieg
An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA.
The Journal of laboratory and clinical medicine 1996;128(2):128-33.
1996: John S Cowdery; J H Chace; Ae-Kyung Yi; Arthur M Krieg
Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(12):4570-5.
1996: Arthur M Krieg
Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA.
Trends in microbiology 1996;4(2):73-6.
1996: Ae-Kyung Yi; J H Chace; John S Cowdery; Arthur M Krieg
IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):558-64.
1996: Arthur M Krieg; S Matson; E Fisher
Oligodeoxynucleotide modifications determine the magnitude of B cell stimulation by CpG motifs.
Antisense & nucleic acid drug development 1996;6(2):133-9.
1995: Arthur M Krieg
CpG DNA: a pathogenic factor in systemic lupus erythematosus?
Journal of clinical immunology 1995;15(6):284-92.
1995: Arthur M Krieg; Ae-Kyung Yi; S Matson; Thomas J Waldschmidt; G A Bishop; R Teasdale; Gary A Koretzky; D M Klinman
CpG motifs in bacterial DNA trigger direct B-cell activation.
Nature 1995;374(6522):546-9.
1994: Q Zhao; Thomas J Waldschmidt; E Fisher; C J Herrera; Arthur M Krieg
Stage-specific oligonucleotide uptake in murine bone marrow B-cell precursors.
Blood 1994;84(11):3660-6.
1994: R M Teasdale; S J Matson; E Fisher; Arthur M Krieg
Inhibition of T4 polynucleotide kinase activity by phosphorothioate and chimeric oligodeoxynucleotides.
Antisense research and development 1994;4(4):295-7.
1993: Arthur M Krieg; J Tonkinson; S Matson; Q Zhao; M Saxon; L M Zhang; U Bhanja; Leonid Yakubov; Cy A Stein
Modification of antisense phosphodiester oligodeoxynucleotides by a 5' cholesteryl moiety increases cellular association and improves efficacy.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(3):1048-52.
1993: S W Louie; L M Ramirez; Arthur M Krieg; C R Maliszewski; Gail A Bishop
Endogenous secretion of IL-4 maintains growth and Thy-1 expression of a transformed B cell clone.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(2):399-406.
1993: Q Zhao; S Matson; C J Herrera; E Fisher; H Yu; Arthur M Krieg
Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleotides.
Antisense research and development 1993;3(1):53-66.
1992: S Matson; Arthur M Krieg
Nonspecific suppression of [3H]thymidine incorporation by "control" oligonucleotides.
Antisense research and development 1992;2(4):325-30.