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Thomas Krieg

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Myocardial Ischemic Preconditioning

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Signal Transduction

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TOP 3
Wenkuan Xin; Xiulan Yang; Robert Barrington; Michael V Cohen; Thomas Krieg; Thomas C Rich; James M Downey
All preconditioning-related G protein-coupled receptors can be demonstrated in the rabbit cardiomyocyte.
Karina Grube; Julia Rüdebusch; Zhelong Xu; Thomas Böckenholt; Carmen Methner; Tobias Müller; Friederike Cuello; Katrin Zimmermann; Xiulan Yang; Stephan B Felix; Michael V Cohen; James M Downey; Thomas Krieg
Evidence for an intracellular localization of the adenosine A2B receptor in rat cardiomyocytes.
Karina Förster; Heike Richter; Mikhail F Alexeyev; Dieter Rosskopf; Stephan B Felix; Thomas Krieg
Inhibition of glycogen synthase kinase 3beta prevents peroxide-induced collapse of mitochondrial membrane potential in rat ventricular myocytes.

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All Publications

2012: Wenkuan Xin; Xiulan Yang; Robert Barrington; Michael V Cohen; Thomas Krieg; Thomas C Rich; James M Downey
All preconditioning-related G protein-coupled receptors can be demonstrated in the rabbit cardiomyocyte.
Journal of cardiovascular pharmacology and therapeutics 2012;17(2):190-8.
2011: Karina Grube; Julia Rüdebusch; Zhelong Xu; Thomas Böckenholt; Carmen Methner; Tobias Müller; Friederike Cuello; Katrin Zimmermann; Xiulan Yang; Stephan B Felix; Michael V Cohen; James M Downey; Thomas Krieg
Evidence for an intracellular localization of the adenosine A2B receptor in rat cardiomyocytes.
Basic research in cardiology 2011;106(3):385-96.
2010: Karina Förster; Heike Richter; Mikhail F Alexeyev; Dieter Rosskopf; Stephan B Felix; Thomas Krieg
Inhibition of glycogen synthase kinase 3beta prevents peroxide-induced collapse of mitochondrial membrane potential in rat ventricular myocytes.
Clinical and experimental pharmacology & physiology 2010;37(7):684-8.
2010: Katharina Schmidt; Renaud Tissier; Bijan Ghaleh; Tim Drogies; Stephan B Felix; Thomas Krieg
Cardioprotective effects of mineralocorticoid receptor antagonists at reperfusion.
European heart journal 2010;31(13):1655-62.
2010: Yanping Liu; Xiulan Yang; Xi-Ming Yang; Sheree Walker; Karina Förster; Michael V Cohen; Thomas Krieg; James M Downey
AMP579 is revealed to be a potent A2b-adenosine receptor agonist in human 293 cells and rabbit hearts.
Basic research in cardiology 2010;105(1):129-37.
2009: C Methner; U Donat; Stephan B Felix; Thomas Krieg
Cardioprotection of bradykinin at reperfusion involves transactivation of the epidermal growth factor receptor via matrix metalloproteinase-8.
Acta physiologica (Oxford, England) 2009;197(4):265-71.
2009: Thomas Krieg; Yanping Liu; Thomas Rütz; Carmen Methner; Xi-Ming Yang; Turhan Dost; Stephan B Felix; Johannes-Peter Stasch; Michael V Cohen; James M Downey
BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts.
European heart journal 2009;30(13):1607-13.
2008: O Maas; U Donat; M Frenzel; T Rütz; Heyo K Kroemer; Stephan B Felix; Thomas Krieg
Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG.
British journal of pharmacology 2008;154(1):25-31.
2008: James M Downey; Thomas Krieg; Michael V Cohen
Mapping preconditioning's signaling pathways: an engineering approach.
Annals of the New York Academy of Sciences 2008;1123():187-96.
2007: Sandra Bien; Alexander Riad; Christoph A Ritter; Matthias Gratz; Florian Olshausen; Dirk Westermann; Markus Grube; Thomas Krieg; Sabine Ciecholewski; Stephan B Felix; Alexander Staudt; Heinz-Peter Schultheiss; Ralf Ewert; Uwe Völker; Carsten Tschöpe; Heyo K Kroemer
The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy.
Cancer research 2007;67(21):10428-35.
2007: Katrin Birkenmeier; Alexander Staudt; Wolf-Hagen Schunck; Irka Janke; Corina Labitzke; Thomas Prange; Christiane Trimpert; Thomas Krieg; Martin Landsberger; Verena Stangl; Stephan B Felix
COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
American journal of physiology. Heart and circulatory physiology 2007;293(4):H2148-54.
2007: Karina Förster; Atsushi Kuno; Natalia Solenkova; Stephan B Felix; Thomas Krieg
The delta-opioid receptor agonist DADLE at reperfusion protects the heart through activation of pro-survival kinases via EGF receptor transactivation.
American journal of physiology. Heart and circulatory physiology 2007;293(3):H1604-8.
2007: Michael V Cohen; Sebastian Philipp; Thomas Krieg; Lin Cui; Atsushi Kuno; Viktoriya Solodushko; James M Downey
Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways.
Journal of molecular and cellular cardiology 2007;42(4):842-51.
2006: Alexander Staudt; Astrid Hummel; Jörg Ruppert; Marcus Dörr; Christiane Trimpert; Katrin Birkenmeier; Thomas Krieg; Yvonne Staudt; Stephan B Felix
Immunoadsorption in dilated cardiomyopathy: 6-month results from a randomized study.
American heart journal 2006;152(4):712.e1-6.
2006: Karina Förster; Ina Paul; Natalia Solenkova; Alexander Staudt; Michael V Cohen; James M Downey; Stephan B Felix; Thomas Krieg
NECA at reperfusion limits infarction and inhibits formation of the mitochondrial permeability transition pore by activating p70S6 kinase.
Basic research in cardiology 2006;101(4):319-26.
2006: Yvonne Staudt; Christiane Trimpert; Katrin Birkenmeier; Thomas Krieg; T Bemmann; D Beug; Stephan B Felix; Alexander Staudt
Effects of antibodies obtained from patients with dilated cardiomyopathy on the function of isolated rat hearts.
European journal of clinical investigation 2006;36(2):85-90.
2005: Thomas Krieg; Sebastian Philipp; Lin Cui; Wolfgang R Dostmann; James M Downey; Michael V Cohen
Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart.
American journal of physiology. Heart and circulatory physiology 2005;288(4):H1976-81.
2004: Thomas Krieg; Qining Qin; Sebastian Philipp; Mikhail F Alexeyev; Michael V Cohen; James M Downey
Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS.
American journal of physiology. Heart and circulatory physiology 2004;287(6):H2606-11.
2004: Xi-Ming Yang; J Bradley Proctor; Lin Cui; Thomas Krieg; James M Downey; Michael V Cohen
Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways.
Journal of the American College of Cardiology 2004;44(5):1103-10.
2004: Thomas Krieg; Xi-Ming Yang; James M Downey; Stephen W Schaffer; Michael V Cohen
Augmented taurine release is not the mechanism of ischemic preconditioning's cardioprotection.
Amino acids 2004;26(3):263-6.
2004: Thomas Krieg; Lin Cui; Qining Qin; Michael V Cohen; James M Downey
Mitochondrial ROS generation following acetylcholine-induced EGF receptor transactivation requires metalloproteinase cleavage of proHB-EGF.
Journal of molecular and cellular cardiology 2004;36(3):435-43.
2004: Xi-Ming Yang; Thomas Krieg; Lin Cui; James M Downey; Michael V Cohen
NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO.
Journal of molecular and cellular cardiology 2004;36(3):411-21.
2004: Olaf Oldenburg; Qining Qin; Thomas Krieg; Xi-Ming Yang; Sebastian Philipp; Stuart D Critz; Michael V Cohen; James M Downey
Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection.
American journal of physiology. Heart and circulatory physiology 2004;286(1):H468-76.
2003: Olaf Oldenburg; Xi-Ming Yang; Thomas Krieg; Keith D Garlid; Michael V Cohen; Gary J Grover; James M Downey
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
Journal of molecular and cellular cardiology 2003;35(9):1035-42.
2003: Thomas Krieg; Michael V Cohen; James M Downey
Mitochondria and their role in preconditioning's trigger phase.
Basic research in cardiology 2003;98(4):228-34.
2003: Thomas Krieg; Martin Landsberger; Mikhail F Alexeyev; Stephan B Felix; Michael V Cohen; James M Downey
Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals.
Cardiovascular research 2003;58(1):196-202.
2002: Thomas Krieg; Qining Qin; Elizabeth C McIntosh; Michael V Cohen; James M Downey
ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases.
American journal of physiology. Heart and circulatory physiology 2002;283(6):H2322-30.