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Lakshmi Krishnan

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Fanny Tzelepis; Kevin G Young; Ahmed Zafer; Valeria Alcon; Renu Dudani; Ellen S Everson; Komal Gurnani; Lakshmi Krishnan; Holger Rüssmann; subash sad
Modulation of antigenic location converts chronic into acute infection by forcing CD8+ T cell recognition.
Nirmal Robinson; Renu Dudani; Lakshmi Krishnan; Scott McComb; Rebecca Mulligan; subash sad
Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium.
Felicity Stark; subash sad; Komal Gurnani; Lakshmi Krishnan
Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells.

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All Publications

2012: Fanny Tzelepis; Kevin G Young; Ahmed Zafer; Valeria Alcon; Renu Dudani; Ellen S Everson; Komal Gurnani; Lakshmi Krishnan; Holger Rüssmann; subash sad
Modulation of antigenic location converts chronic into acute infection by forcing CD8+ T cell recognition.
Cell reports 2012;2(6):1710-21.
2012: Nirmal Robinson; Renu Dudani; Lakshmi Krishnan; Scott McComb; Rebecca Mulligan; subash sad
Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium.
Nature immunology 2012;13(10):954-62.
2012: Felicity Stark; subash sad; Komal Gurnani; Lakshmi Krishnan
Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells.
PloS one 2012;7(2):e32211.
2011: Kevin G Young; Renu Dudani; Lakshmi Krishnan; Susanne MacLean; subash sad
CD8+ T cells primed in the periphery provide time-bound immune-surveillance to the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1192-200.
2010: Anindita Chattopadhyay; Nirmal Robinson; Jagdeep K Sandhu; B Brett Finlay; subash sad; Lakshmi Krishnan
Salmonella enterica serovar Typhimurium-induced placental inflammation and not bacterial burden correlates with pathology and fatal maternal disease.
Infection and immunity 2010;78(5):2292-301.
2010: Lakshmi Krishnan; Lise Deschatelets; Felicity Stark; Komal Gurnani; G Dennis Sprott
Archaeosome adjuvant overcomes tolerance to tumor-associated melanoma antigens inducing protective CD8 T cell responses.
Clinical & developmental immunology 2010;2010():578432.
2010: Lakshmi Krishnan; Branka Pejcic-Karapetrovic; Komal Gurnani; Ahmed Zafer; subash sad
Pregnancy does not deter the development of a potent maternal protective CD8+ T-cell acquired immune response against Listeria monocytogenes despite preferential placental colonization.
American journal of reproductive immunology (New York, N.Y. : 1989) 2010;63(1):54-65.
2009: Felicity Stark; subash sad; Lakshmi Krishnan
Intracellular bacterial vectors that induce CD8(+) T cells with similar cytolytic abilities but disparate memory phenotypes provide contrasting tumor protection.
Cancer research 2009;69(10):4327-34.
2008: Renu Dudani; Kaja Murali-Krishna; Lakshmi Krishnan; subash sad
IFN-gamma induces the erosion of preexisting CD8 T cell memory during infection with a heterologous intracellular bacterium.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1700-9.
2008: subash sad; Renu Dudani; Komal Gurnani; Marsha Russell; Henk van Faassen; Brett Finlay; Lakshmi Krishnan
Pathogen proliferation governs the magnitude but compromises the function of CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):5853-61.
2008: Lakshmi Krishnan; G Dennis Sprott
Archaeosome adjuvants: immunological capabilities and mechanism(s) of action.
Vaccine 2008;26(17):2043-55.
2008: Renu Dudani; Marsha Russell; Henk van Faassen; Lakshmi Krishnan; subash sad
Mutation in the Fas pathway impairs CD8+ T cell memory.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2933-41.
2007: Branka Pejcic-Karapetrovic; Komal Gurnani; Marsha S Russell; B Brett Finlay; subash sad; Lakshmi Krishnan
Pregnancy impairs the innate immune resistance to Salmonella typhimurium leading to rapid fatal infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6088-96.
2007: Marsha S Russell; Monica Iskandar; Oksana L Mykytczuk; John H E Nash; Lakshmi Krishnan; subash sad
A reduced antigen load in vivo, rather than weak inflammation, causes a substantial delay in CD8+ T cell priming against Mycobacterium bovis (bacillus Calmette-Guérin).
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):211-20.
2007: Lakshmi Krishnan; Komal Gurnani; Chantal J Dicaire; Henk van Faassen; Ahmed Zafer; Carsten J Kirschning; subash sad; G Dennis Sprott
Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an archaeosome adjuvant independent of TLR2.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2396-406.
2006: Rachel A Luu; Komal Gurnani; Renu Dudani; Rajagopal Kammara; Henk van Faassen; Jean-Claude Sirard; Lakshmi Krishnan; subash sad
Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1516-25.
2005: Henk van Faassen; Marsha Saldanha; Deanna Gilbertson; Renu Dudani; Lakshmi Krishnan; subash sad
Reducing the stimulation of CD8+ T cells during infection with intracellular bacteria promotes differentiation primarily into a central (CD62LhighCD44high) subset.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5341-50.
2004: G Dennis Sprott; Chantal J Dicaire; Komal Gurnani; subash sad; Lakshmi Krishnan
Activation of dendritic cells by liposomes prepared from phosphatidylinositol mannosides from Mycobacterium bovis bacillus Calmette-Guerin and adjuvant activity in vivo.
Infection and immunity 2004;72(9):5235-46.
2004: Komal Gurnani; Jessica Kennedy; subash sad; G Dennis Sprott; Lakshmi Krishnan
Phosphatidylserine receptor-mediated recognition of archaeosome adjuvant promotes endocytosis and MHC class I cross-presentation of the entrapped antigen by phagosome-to-cytosol transport and classical processing.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):566-78.
2004: G Dennis Sprott; Chantal J Dicaire; Komal Gurnani; Lise Deschatelets; Lakshmi Krishnan
Liposome adjuvants prepared from the total polar lipids of Haloferax volcanii, Planococcus spp. and Bacillus firmus differ in ability to elicit and sustain immune responses.
Vaccine 2004;22(17-18):2154-62.
2004: Henk van Faassen; Renu Dudani; Lakshmi Krishnan; subash sad
Prolonged antigen presentation, APC-, and CD8+ T cell turnover during mycobacterial infection: comparison with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3491-500.
2003: Yvan Chapdelaine; Dean K Smith; Joao Pedras-Vasconcelos; Lakshmi Krishnan; subash sad
Increased CD8+ T cell memory to concurrent infection at the expense of increased erosion of pre-existing memory: the paradoxical role of IL-15.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5454-60.
2003: G Dennis Sprott; subash sad; L Perry Fleming; Chantal J Dicaire; Girishchandra B Patel; Lakshmi Krishnan
Archaeosomes varying in lipid composition differ in receptor-mediated endocytosis and differentially adjuvant immune responses to entrapped antigen.
Archaea (Vancouver, B.C.) 2003;1(3):151-64.
2003: Lakshmi Krishnan; subash sad; Girishchandra B Patel; G Dennis Sprott
Archaeosomes induce enhanced cytotoxic T lymphocyte responses to entrapped soluble protein in the absence of interleukin 12 and protect against tumor challenge.
Cancer research 2003;63(10):2526-34.
2003: G Dennis Sprott; Girishchandra B Patel; Lakshmi Krishnan
Archaeobacterial ether lipid liposomes as vaccine adjuvants.
Methods in enzymology 2003;373():155-72.
2003: subash sad; Lakshmi Krishnan
Maintenance and attrition of T-cell memory.
Critical reviews in immunology 2003;23(1-2):129-47.
2002: Renu Dudani; Yvan Chapdelaine; Henk van Faassen Hv; Dean K Smith; Hao Shen; Lakshmi Krishnan; subash sad
Multiple mechanisms compensate to enhance tumor-protective CD8(+) T cell response in the long-term despite poor CD8(+) T cell priming initially: comparison between an acute versus a chronic intracellular bacterium expressing a model antigen.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5737-45.
2002: Renu Dudani; Yvan Chapdelaine; Henk van Faassen; Dean K Smith; Hao Shen; Lakshmi Krishnan; subash sad
Preexisting inflammation due to Mycobacterium bovis BCG infection differentially modulates T-cell priming against a replicating or nonreplicating immunogen.
Infection and immunity 2002;70(4):1957-64.
2001: J Wayne Conlan; Lakshmi Krishnan; Gordon E Willick; Girishchandra B Patel; G Dennis Sprott
Immunization of mice with lipopeptide antigens encapsulated in novel liposomes prepared from the polar lipids of various Archaeobacteria elicits rapid and prolonged specific protective immunity against infection with the facultative intracellular pathogen, Listeria monocytogenes.
Vaccine 2001;19(25-26):3509-17.
2001: Lakshmi Krishnan; subash sad; Girishchandra B Patel; G Dennis Sprott
The potent adjuvant activity of archaeosomes correlates to the recruitment and activation of macrophages and dendritic cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1885-93.
2000: Lakshmi Krishnan; subash sad; Girishchandra B Patel; G Dennis Sprott
Archaeosomes induce long-term CD8+ cytotoxic T cell response to entrapped soluble protein by the exogenous cytosolic pathway, in the absence of CD4+ T cell help.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5177-85.
2000: Lakshmi Krishnan; Chantal J Dicaire; Girishchandra B Patel; G Dennis Sprott
Archaeosome vaccine adjuvants induce strong humoral, cell-mediated, and memory responses: comparison to conventional liposomes and alum.
Infection and immunity 2000;68(1):54-63.
1999: G Dennis Sprott; J Brisson; Chantal J Dicaire; A K Pelletier; Lise Deschatelets; Lakshmi Krishnan; Girishchandra B Patel
A structural comparison of the total polar lipids from the human archaea Methanobrevibacter smithii and Methanosphaera stadtmanae and its relevance to the adjuvant activities of their liposomes.
Biochimica et biophysica acta 1999;1440(2-3):275-88.
1999: subash sad; Lakshmi Krishnan
Cytokine deprivation of naive CD8+ T cells promotes minimal cell cycling but maximal cytokine synthesis and autonomous proliferation subsequently: a mechanism of self-regulation.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2443-51.
1997: subash sad; Lakshmi Krishnan; R Chris Bleackley; D Kägi; H Hengartner; TR Mosmann
Cytotoxicity and weak CD40 ligand expression of CD8+ type 2 cytotoxic T cells restricts their potential B cell helper activity.
European journal of immunology 1997;27(4):914-22.