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Deanna Kroetz

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Pharmacogenetics

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Heather E Wheeler; Eric P Winer; Claudia Wing; Hitoshi Zembutsu; Robert Michael Baldwin; Nancy J Cox; Eric Gamazon; Clifford A Hudis; Chen Jiang; Deanna L Kroetz; Michiaki Kubo; Yusuke Nakamura; Uchenna O Njiaju; Chidiamara Njoku; Kouros Owzar; Mark J Ratain; Ivo Shterev; Lawrence N Shulman; Dorothy Watson; Mary Eileen Dolan
Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
Lionel D Lewis; Svetlana Markova; Howard L McLeod; Antonius A Miller; Kouros Owzar; Mark J Ratain; Robert R Bies; Merrill J Egorin; Chen Jiang; Deanna L Kroetz
The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance).
R Michael Baldwin; Aparna Chhibber; Rachel J Eclov; Paula N Friedman; Clifford A Hudis; Chen Jiang; Eric Jorgenson; Michiaki Kubo; Howard L McLeod; Joel Mefford; Yusuke Nakamura; Kouros Owzar; Mark J Ratain; Lawrence N Shulman; Dorothy Watson; Eric P Winer; John S Witte; Hitoshi Zembutsu; Deanna L Kroetz
A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.

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All Publications

2013: Heather E Wheeler; Eric P Winer; Claudia Wing; Hitoshi Zembutsu; Robert Michael Baldwin; Nancy J Cox; Eric Gamazon; Clifford A Hudis; Chen Jiang; Deanna L Kroetz; Michiaki Kubo; Yusuke Nakamura; Uchenna O Njiaju; Chidiamara Njoku; Kouros Owzar; Mark J Ratain; Ivo Shterev; Lawrence N Shulman; Dorothy Watson; Mary Eileen Dolan
Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(2):491-9.
2013: Lionel D Lewis; Svetlana Markova; Howard L McLeod; Antonius A Miller; Kouros Owzar; Mark J Ratain; Robert R Bies; Merrill J Egorin; Chen Jiang; Deanna L Kroetz
The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance).
Pharmacogenetics and genomics 2013;23(1):29-33.
2012: R Michael Baldwin; Aparna Chhibber; Rachel J Eclov; Paula N Friedman; Clifford A Hudis; Chen Jiang; Eric Jorgenson; Michiaki Kubo; Howard L McLeod; Joel Mefford; Yusuke Nakamura; Kouros Owzar; Mark J Ratain; Lawrence N Shulman; Dorothy Watson; Eric P Winer; John S Witte; Hitoshi Zembutsu; Deanna L Kroetz
A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(18):5099-109.
2012: Yusuke Nakamura; Mark J Ratain; Nancy J Cox; Deanna L Kroetz; Howard L McLeod; David A Flockhart
Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial.
Journal of the National Cancer Institute 2012;104(16):1264; author reply 1266-8.
2012: Yingmei Liu; Svetlana Markova; Janine Micheli; Jean L Olson; Heather K Webb; Hisayo Fukushima; Deanna L Kroetz
Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor κB signaling.
The Journal of pharmacology and experimental therapeutics 2012;341(3):725-34.
2012: P Matsson; K Morrissey; J Xuan; Sook Wah Yee; G Jenkins; Eric Jorgenson; Deanna L Kroetz; S Markova; Kathleen M Giacomini
Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping.
The pharmacogenomics journal 2012;12(3):214-26.
2012: M A Martin; M Pirmohamed; Betty J Dong; D W Haas; Teri E Klein; Deanna L Kroetz
Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing.
Clinical pharmacology and therapeutics 2012;91(4):734-8.
2011: M J Kim; P Skewes-Cox; H Fukushima; S Hesselson; Sook Wah Yee; L B Ramsey; L Nguyen; J L Eshragh; Richard A Castro; C C Wen; Doug Stryke; Susan J Johns; Thomas E Ferrin; Pui-Yan Kwok; Mary Relling; Kathleen M Giacomini; Deanna L Kroetz; Nadav Ahituv
Functional characterization of liver enhancers that regulate drug-associated transporters.
Clinical pharmacology and therapeutics 2011;89(4):571-8.
2011: Laura M Hodges; Svetlana M Markova; Leslie W Chinn; Jason M Gow; Deanna L Kroetz; Teri E Klein; Russ B Altman
Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein).
Pharmacogenetics and genomics 2011;21(3):152-61.
2010: Libusha Kelly; Hisayo Fukushima; Rachel Karchin; Jason M Gow; Leslie W Chinn; Ursula Pieper; Mark Segal; Deanna L Kroetz; Andrej Sali
Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.
Protein science : a publication of the Protein Society 2010;19(11):2110-21.
2010: Deanna L Kroetz; Sook Wah Yee; Kathleen M Giacomini
The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.
Clinical pharmacology and therapeutics 2010;87(1):109-16.
2009: Libusha Kelly; Ursula Pieper; Narayanan Eswar; Franklin A Hays; Min Li; Zygy Roe-Zurz; Deanna L Kroetz; Kathleen M Giacomini; Robert M Stroud; Andrej Sali
A survey of integral alpha-helical membrane proteins.
Journal of structural and functional genomics 2009;10(4):269-80.
2009: Deanna L Kroetz; Nadav Ahituv; Esteban González Burchard; Su Guo; Andrej Sali; Kathleen M Giacomini
Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy.
Pharmacogenomics 2009;10(10):1569-76.
2009: Federico Innocenti; Deanna L Kroetz; Erin G Schuetz; M Eileen Dolan; Jacqueline Ramírez; Mary Relling; Peixian Chen; Soma Das; Gary Rosner; Mark J Ratain
Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(16):2604-14.
2009: Stephanie E Hesselson; Pär Matsson; James E Shima; Hisayo Fukushima; Sook Wah Yee; Yuya Kobayashi; Jason M Gow; Connie Ha; Benjamin Ma; Annie Poon; Susan J Johns; Doug Stryke; Richard A Castro; Harunobu Tahara; Ji Ha Choi; Ligong Chen; Nicolas Picard; Elin Sjödin; Maarke J E Roelofs; Thomas E Ferrin; Richard Myers; Deanna L Kroetz; Pui-Yan Kwok; Kathleen M Giacomini
Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation.
PloS one 2009;4(9):e6942.
2008: Kimberly L Fife; Yingmei Liu; Kara R Schmelzer; Hsing-Ju Tsai; In-Hae Kim; Christophe Morisseau; Bruce D Hammock; Deanna L Kroetz
Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation.
The Journal of pharmacology and experimental therapeutics 2008;327(3):707-15.
2008: Piotr Tutka; Delia Dempsey; Peyton Jacob; Neal L Benowitz; Deanna L Kroetz
Nicotine metabolism in pregnant and nonpregnant rabbits.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2008;10(8):1385-90.
2008: Nada Abla; Leslie W Chinn; Tsutomu Nakamura; Li Liu; Conrad C Huang; Susan J Johns; Michiko Kawamoto; Doug Stryke; Travis R Taylor; Thomas E Ferrin; Kathleen M Giacomini; Deanna L Kroetz
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.
The Journal of pharmacology and experimental therapeutics 2008;325(3):859-68.
2008: Jason M Gow; Laura M Hodges; Leslie W Chinn; Deanna L Kroetz
Substrate-dependent effects of human ABCB1 coding polymorphisms.
The Journal of pharmacology and experimental therapeutics 2008;325(2):435-42.
2008: Jason M Gow; Leslie W Chinn; Deanna L Kroetz
The effects of ABCB1 3'-untranslated region variants on mRNA stability.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(1):10-5.
2007: Sunil Parikh; Jean Bosco Ouedraogo; J A Goldstein; Philip J Rosenthal; Deanna L Kroetz
Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.
Clinical pharmacology and therapeutics 2007;82(2):197-203.
2007: Leslie W Chinn; Jason M Gow; Man Ming Tse; Stephen L Becker; Deanna L Kroetz
Interindividual variability in the effect of atazanavir and saquinavir on the expression of lymphocyte P-glycoprotein.
The Journal of antimicrobial chemotherapy 2007;60(1):61-7.
2007: Valerie Y Ng; Yong Huang; L Manmohan Reddy; John R Falck; Emil T Lin; Deanna L Kroetz
Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(7):1126-34.
2007: david bangsberg; Deanna L Kroetz; Steven G Deeks
Adherence-resistance relationships to combination HIV antiretroviral therapy.
Current HIV/AIDS reports 2007;4(2):65-72.
2007: Nicole Soranzo; Libusha Kelly; Lillian Martinian; Mari-Wyn Burley; Maria Thom; Andrej Sali; Deanna L Kroetz; David B Goldstein; Sanjay M Sisodiya
Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.
Epilepsia 2007;48(4):674-83.
2007: Hotcherl Jeong; Ira Herskowitz; Deanna L Kroetz; Jasper Rine
Function-altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay.
PLoS genetics 2007;3(3):e39.
2007: Kathleen M Giacomini; Claire M Brett; R B Altman; Neal L Benowitz; M E Dolan; David A Flockhart; J A Johnson; Daniel F Hayes; T Klein; R M Krauss; Deanna L Kroetz; howard mcleod; A T Nguyen; M J Ratain; Mary Relling; V Reus; Dan Mark Roden; C A Schaefer; Alan R Shuldiner; Todd C Skaar; K Tantisira; R F Tyndale; L Wang; Richard M Weinshilboum; Scott Weiss; Issam Zineh
The pharmacogenetics research network: from SNP discovery to clinical drug response.
Clinical pharmacology and therapeutics 2007;81(3):328-45.
2007: Leslie W Chinn; Deanna L Kroetz
ABCB1 pharmacogenetics: progress, pitfalls, and promise.
Clinical pharmacology and therapeutics 2007;81(2):265-9.
2006: Valerie Y Ng; Christophe Morisseau; John R Falck; Bruce D Hammock; Deanna L Kroetz
Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(11):2462-8.
2006: Deanna L Kroetz
Role for drug transporters beyond tumor resistance: hepatic functional imaging and genotyping of multidrug resistance transporters for the prediction of irinotecan toxicity.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(26):4225-7.
2006: Fengyun Xu; Valerie Y Ng; Deanna L Kroetz; Paul R Ortiz de Montellano
CYP4 isoform specificity in the omega-hydroxylation of phytanic acid, a potential route to elimination of the causative agent of Refsum's disease.
The Journal of pharmacology and experimental therapeutics 2006;318(2):835-9.
2006: Zhigang Yu; Valerie Y Ng; Ping Su; Marguerite M Engler; Mary B Engler; Yong Huang; Emil Lin; Deanna L Kroetz
Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid.
The Journal of pharmacology and experimental therapeutics 2006;317(2):732-8.
2006: Chiho Komoto; Tsutomu Nakamura; Toshiyuki Sakaeda; Deanna L Kroetz; Toshio Yamada; Hideaki Omatsu; Tatsuya Koyama; Noboru Okamura; Ikuya Miki; Takao Tamura; Nobuo Aoyama; Masato Kasuga; Katsuhiko Okumura
MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer.
Drug metabolism and pharmacokinetics 2006;21(2):126-32.
2006: Ilaria Badagnani; Marco Sorani; Robert H Edwards; Chaline Brown; Richard A Castro; Conrad C Huang; Doug Stryke; Michiko Kawamoto; Susan J Johns; Elaine J Carlson; Travis Taylor; Wendy Chan; Melanie de la Cruz; Thomas E Ferrin; Esteban González Burchard; Ira Herskowitz; Deanna L Kroetz; Kathleen M Giacomini
PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network.
Pharmacological reviews 2006;58(1):5-6.
2006: Yan Shu; Thomas J Urban; Maya K Leabman; Tomoe Fujita; Andrew R Erdman; Leah L Lagpacan; Chaline Brown; Richard A Castro; Conrad C Huang; Doug Stryke; Michiko Kawamoto; Susan J Johns; Travis R Taylor; Wendy Chan; Melanie de la Cruz; Elaine J Carlson; Thomas E Ferrin; Claire M Brett; Esteban González Burchard; Ira Herskowitz; Deanna L Kroetz; Kathleen M Giacomini
PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters.
Pharmacological reviews 2006;58(1):3-4.
2006: Tan D Nguyen; Jason M Gow; Leslie W Chinn; Libusha Kelly; Hotcherl Jeong; Conrad C Huang; Doug Stryke; Michiko Kawamoto; Susan J Johns; Elaine Carlson; Travis Taylor; Thomas E Ferrin; Andrej Sali; Kathleen M Giacomini; Deanna L Kroetz
PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network.
Pharmacological reviews 2006;58(1):1-2.
2005: Tommy Andersson; David A Flockhart; David B Goldstein; Shiew-Mei Huang; Deanna L Kroetz; Patrice M Milos; Mark J Ratain; Kenneth Thummel
Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests.
Clinical pharmacology and therapeutics 2005;78(6):559-81.
2005: Danxin Wang; Andrew D Johnson; Audrey C Papp; Deanna L Kroetz; Wolfgang Sadée
Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability.
Pharmacogenetics and genomics 2005;15(10):693-704.
2005: Deanna L Kroetz; Fengyun Xu
Regulation and inhibition of arachidonic acid omega-hydroxylases and 20-HETE formation.
Annual review of pharmacology and toxicology 2005;45():413-38.
2004: Christiane Pauli-Magnus; Deanna L Kroetz
Functional implications of genetic polymorphisms in the multidrug resistance gene MDR1 (ABCB1).
Pharmaceutical research 2004;21(6):904-13.
2004: Zhigang Yu; Benjamin B Davis; Christophe Morisseau; Bruce D Hammock; Jean L Olson; Deanna L Kroetz; Robert H Weiss
Vascular localization of soluble epoxide hydrolase in the human kidney.
American journal of physiology. Renal physiology 2004;286(4):F720-6.
2004: Fengyun Xu; John R Falck; Paul R. Ortiz de Montellano; Deanna L Kroetz
Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes.
The Journal of pharmacology and experimental therapeutics 2004;308(3):887-95.
2003: Christiane Pauli-Magnus; John Feiner; Claire M Brett; Emil Lin; Deanna L Kroetz
No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects.
Clinical pharmacology and therapeutics 2003;74(5):487-98.
2003: Deanna L Kroetz; Christiane Pauli-Magnus; Laura M Hodges; Conrad C Huang; Michiko Kawamoto; Susan J Johns; Doug Stryke; Thomas E Ferrin; Joseph DeYoung; Travis Taylor; Elaine J Carlson; Ira Herskowitz; Kathleen M Giacomini; andrew clark
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.
Pharmacogenetics 2003;13(8):481-94.
2003: Maya K Leabman; Conrad C Huang; Joseph DeYoung; Elaine J Carlson; Travis R Taylor; Melanie de la Cruz; Susan J Johns; Doug Stryke; Michiko Kawamoto; Thomas J Urban; Deanna L Kroetz; Thomas E Ferrin; andrew clark; Neil Risch; Ira Herskowitz; Kathleen M Giacomini
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5896-901.
2002: Fengyun Xu; Wesley O Straub; Winnie Pak; Ping Su; Kristopher G Maier; Ming Yu; Richard J Roman; Paul R. Ortiz de Montellano; Deanna L Kroetz
Antihypertensive effect of mechanism-based inhibition of renal arachidonic acid omega-hydroxylase activity.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;283(3):R710-20.
2002: Christiane Pauli-Magnus; Deanna L Kroetz
MDR1 reference sequence and reference function.
Clinical pharmacology and therapeutics 2002;72(1):100-1.
2002: Deanna L Kroetz; Darryl C Zeldin
Cytochrome P450 pathways of arachidonic acid metabolism.
Current opinion in lipidology 2002;13(3):273-83.
2002: Laurie A LeBrun; Fengyun Xu; Deanna L Kroetz; Paul R. Ortiz de Montellano
Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family.
Biochemistry 2002;41(18):5931-7.
2002: Huijun Z Ring; Deanna L Kroetz
Candidate gene approach for pharmacogenetic studies.
Pharmacogenomics 2002;3(1):47-56.
2000: Z Yu; F Xu; LM Huse; Christophe Morisseau; Alison J Draper; John William Newman; Carol Parker; L Graham; Marguerite M Engler; B D Hammock; Darryl C Zeldin; Deanna L Kroetz
Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.
Circulation research 2000;87(11):992-8.
2000: Z Yu; LM Huse; P Adler; L Graham; J Ma; Darryl C Zeldin; Deanna L Kroetz
Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney.
Molecular pharmacology 2000;57(5):1011-20.
2000: L Zhang; W Gorset; Carla B Washington; Terrence F Blaschke; Deanna L Kroetz; Kathleen M Giacomini
Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(3):329-34.
2000: Ute R Hoch; jun zhang; Deanna L Kroetz; Paul R. Ortiz de Montellano
Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases.
Archives of biochemistry and biophysics 2000;373(1):63-71.
1999: Marguerite M Engler; Mary B Engler; Deanna L Kroetz; K D Boswell; E Neeley; S M Krassner
The effects of a diet rich in docosahexaenoic acid on organ and vascular fatty acid composition in spontaneously hypertensive rats.
Prostaglandins, leukotrienes, and essential fatty acids 1999;61(5):289-95.
1999: Marguerite M Engler; Mary B Engler; Theodore L Goodfriend; Dennis L Ball; Z Yu; Ping Su; Deanna L Kroetz
Docosahexaenoic acid is an antihypertensive nutrient that affects aldosterone production in SHR.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1999;221(1):32-8.
1998: Deanna L Kroetz; P Yook; Philippe Costet; P Bianchi; Thierry Pineau
Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes.
The Journal of biological chemistry 1998;273(47):31581-9.
1998: H Wang; R Dick; H Yin; E Licad-Coles; Deanna L Kroetz; Grazyna D Szklarz; GR Harlow; James Halpert; Maria Almira Correia
Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe.
Biochemistry 1998;37(36):12536-45.
1998: Ping Su; K M Kaushal; Deanna L Kroetz
Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR.
The American journal of physiology 1998;275(2 Pt 2):R426-38.
1997: Deanna L Kroetz; LM Huse; A Thuresson; M P Grillo
Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney.
Molecular pharmacology 1997;52(3):362-72.
1995: S S Lee; Thierry Pineau; J Drago; E J Lee; J W Owens; Deanna L Kroetz; Pedro Fernandez-Salguero; Heiner Westphal; Frank J Gonzalez
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
Molecular and cellular biology 1995;15(6):3012-22.
1993: Deanna L Kroetz; O W McBride; Frank J Gonzalez
Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms.
Biochemistry 1993;32(43):11606-17.