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Povl Krogsgaard-Larsen

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Stine B Vogensen; Petrine Wellendorph; H Steve White; Nrupa Borkar; Lars Jørgensen; Povl Krogsgaard-Larsen; Karsten K Madsen; Arne Schousboe; Jonas Skovgaard-Petersen; Rasmus P Clausen
Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.
Anders A Jensen; Jacob Krall; Povl Krogsgaard-Larsen; Martin H F Pedersen; Niels Plath; Tine B Stensbøl; Petrine Wellendorph; David E Gloriam; Vignir Isberg; Bente Frølund
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.
Povl Krogsgaard-Larsen; Peter Thostrup; Flemming Besenbacher
Scientific social responsibility: a call to arms.

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2013: Stine B Vogensen; Petrine Wellendorph; H Steve White; Nrupa Borkar; Lars Jørgensen; Povl Krogsgaard-Larsen; Karsten K Madsen; Arne Schousboe; Jonas Skovgaard-Petersen; Rasmus P Clausen
Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.
Journal of medicinal chemistry 2013;56(5):2160-4.
2013: Anders A Jensen; Jacob Krall; Povl Krogsgaard-Larsen; Martin H F Pedersen; Niels Plath; Tine B Stensbøl; Petrine Wellendorph; David E Gloriam; Vignir Isberg; Bente Frølund
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.
Journal of medicinal chemistry 2013;56(3):1211-27.
2011: Povl Krogsgaard-Larsen; Peter Thostrup; Flemming Besenbacher
Scientific social responsibility: a call to arms.
Angewandte Chemie (International ed. in English) 2011;50(46):10738-40.
2011: Karsten K Madsen; Arne Schousboe; Rasmus P Clausen; Bjarke Ebert; Povl Krogsgaard-Larsen; H Steve White
Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol.
The Journal of pharmacology and experimental therapeutics 2011;338(1):214-9.
2009: Marie Gottschalk; Anders Bach; Jakob Lerche Hansen; Povl Krogsgaard-Larsen; Anders Skov Kristensen; Kristian Strømgaard
Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction.
Neurochemical research 2009;34(10):1729-37.
2009: Rasmus P Clausen; Peter Naur; Anders Skov Kristensen; Jeremy R Greenwood; Mette Strange; Hans Bräuner-Osborne; Anders A Jensen; Anne Sophie T Nielsen; Ulla Geneser; Lone M Ringgaard; Birgitte Nielsen; Darryl S Pickering; Lotte Brehm; Michael Gajhede; Povl Krogsgaard-Larsen; Jette S Kastrup
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.
Journal of medicinal chemistry 2009;52(15):4911-22.
2009: Karsten K Madsen; Rasmus P Clausen; Orla M Larsson; Povl Krogsgaard-Larsen; Arne Schousboe; H White
Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs.
Journal of neurochemistry 2009;109 Suppl 1():139-44.
2008: Misty Smith; Gerald W Saunders; Rasmus P Clausen; Bente Frølund; Povl Krogsgaard-Larsen; Orla M Larsson; Arne Schousboe; Karen S Wilcox; H White
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC).
Epilepsy research 2008;79(1):6-13.
2007: Christian Madsen; Anders A Jensen; Tommy Liljefors; Uffe Kristiansen; Birgitte Nielsen; Camilla P Hansen; Mogens Larsen; Bjarke Ebert; Benny Bang-Andersen; Povl Krogsgaard-Larsen; Bente Frølund
5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
Journal of medicinal chemistry 2007;50(17):4147-61.
2007: Stine B Vogensen; Karla Frydenvang; Jeremy R Greenwood; Giovanna Postorino; Birgitte Nielsen; Darryl S Pickering; Bjarke Ebert; Ulrik Bølcho; Jan Egebjerg; Michael Gajhede; Jette S Kastrup; Tommy N Johansen; Rasmus P Clausen; Povl Krogsgaard-Larsen
A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
Journal of medicinal chemistry 2007;50(10):2408-14.
2007: Charlotte G Jørgensen; Hans Bräuner-Osborne; Birgitte Nielsen; Jan Kehler; Rasmus P Clausen; Povl Krogsgaard-Larsen; Ulf Madsen
Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.
Bioorganic & medicinal chemistry 2007;15(10):3524-38.
2007: Bente Frølund; Lars S Jensen; Signe I Storustovu; Tine B Stensbøl; Bjarke Ebert; Jan Kehler; Povl Krogsgaard-Larsen; Tommy Liljefors
4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships.
Journal of medicinal chemistry 2007;50(8):1988-92.
2007: Charlotte G Jørgensen; Rasmus P Clausen; Kasper B Hansen; Hans Bräuner-Osborne; Birgitte Nielsen; Bjørn Metzler; Birgitte Bjørn Metzler; Jan Kehler; Povl Krogsgaard-Larsen; Ulf Madsen
Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid.
Organic & biomolecular chemistry 2007;5(3):463-71.
2006: Rasmus P Clausen; Bente Frølund; Orla M Larsson; Arne Schousboe; Povl Krogsgaard-Larsen; H White
A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS.
Neurochemistry international 2006;48(6-7):637-42.
2006: Dorte Krehan; Signe I Storustovu; Tommy Liljefors; Bjarke Ebert; Birgitte Nielsen; Povl Krogsgaard-Larsen; Bente Frølund
Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.
Journal of medicinal chemistry 2006;49(4):1388-96.
2006: Rasmus P Clausen; Karsten Madsen; Orla M Larsson; Bente Frølund; Povl Krogsgaard-Larsen; Arne Schousboe
Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors.
Advances in pharmacology (San Diego, Calif.) 2006;54():265-84.
2006: Povl Krogsgaard-Larsen; Bente Frølund; Tommy Liljefors
GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.
Advances in pharmacology (San Diego, Calif.) 2006;54():53-71.
2006: Signe Høg; Jeremy R Greenwood; Karsten B Madsen; Orla M Larsson; Bente Frølund; Arne Schousboe; Povl Krogsgaard-Larsen; Rasmus P Clausen
Structure-activity relationships of selective GABA uptake inhibitors.
Current topics in medicinal chemistry 2006;6(17):1861-82.
2005: Bente Frølund; Jeremy R Greenwood; Mai Marie Holm; Jan Egebjerg; Ulf Madsen; Birgitte Nielsen; Hans Bräuner-Osborne; Tine B Stensbøl; Povl Krogsgaard-Larsen
Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.
Bioorganic & medicinal chemistry 2005;13(18):5391-8.
2005: Anders A Jensen; Bente Frølund; Tommy Liljefors; Povl Krogsgaard-Larsen
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Journal of medicinal chemistry 2005;48(15):4705-45.
2005: Stine B Vogensen; Rasmus P Clausen; Jeremy R Greenwood; Tommy N Johansen; Darryl S Pickering; Birgitte Nielsen; Bjarke Ebert; Povl Krogsgaard-Larsen
Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.
Journal of medicinal chemistry 2005;48(9):3438-42.
2005: Patrick Couvreur; Diane Barguer; Daan J A Crommelin; Dominique Duchêne; Joachim W Engels; David J Kerr; Povl Krogsgaard-Larsen; Dirk K Meijer; Rodolfo Paoletti; Ernst Wagner
EUFEPS report. Contribution of academic research to discovery and development of medicines: current status and future opportunities.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;24(2-3):245-52.
2005: Rasmus P Clausen; Ejner K Moltzen; Jens Perregaard; Sibylle M Lenz; Connie Sanchez; Erik Falch; Bente Frølund; Tina Bolvig; Alan Sarup; Orla M Larsson; Arne Schousboe; Povl Krogsgaard-Larsen
Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues.
Bioorganic & medicinal chemistry 2005;13(3):895-908.
2005: H White; William P Watson; Suzanne L Hansen; Scott Slough; Jens Perregaard; Alan Sarup; Tina Bolvig; Gitte Petersen; Orla M Larsson; Rasmus P Clausen; Bente Frølund; Erik Falch; Povl Krogsgaard-Larsen; Arne Schousboe
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
The Journal of pharmacology and experimental therapeutics 2005;312(2):866-74.
2005: Bente Frølund; Lars S Jensen; Luca Guandalini; Carolina Canillo; Henrik T Vestergaard; Uffe Kristiansen; Birgitte Nielsen; Tine B Stensbøl; Christian Madsen; Povl Krogsgaard-Larsen; Tommy Liljefors
Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.
Journal of medicinal chemistry 2005;48(2):427-39.
2004: Povl Krogsgaard-Larsen; Bente Frølund; Tommy Liljefors; Bjarke Ebert
GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.
Biochemical pharmacology 2004;68(8):1573-80.
2004: Victor N'goka; Tine B Stenbøl; Povl Krogsgaard-Larsen; Gilbert Schlewer
Synthesis and GABA uptake inhibitory properties of 6-aryl iminoxymethyl substituted nipecotic acids.
European journal of medicinal chemistry 2004;39(10):889-95.
2004: Anders A Jensen; Ivan Mikkelsen; Bente Frølund; Karla Frydenvang; Lotte Brehm; Jerzy W Jaroszewski; Hans Bräuner-Osborne; Erik Falch; Povl Krogsgaard-Larsen
Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors.
European journal of pharmacology 2004;497(2):125-37.
2004: Lotte Brehm; Jeremy R Greenwood; Frank A Sløk; Mai Marie Holm; Birgitte Nielsen; Ulla Geneser; Tine B Stensbøl; Hans Bräuner-Osborne; Mikael Begtrup; Jan Egebjerg; Povl Krogsgaard-Larsen
Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA.
Chirality 2004;16(7):452-66.
2004: Victor N'Goka; Caterina Bissantz; Philippe Bisel; Tine B Stenbøl; Povl Krogsgaard-Larsen; Gilbert Schlewer
Syntheses and GABA uptake properties of 6-ether- and 6-enol ether-substituted nipecotic acids.
European journal of medicinal chemistry 2004;39(7):633-8.
2004: Martin Mortensen; Uffe Kristiansen; Bjarke Ebert; Bente Frølund; Povl Krogsgaard-Larsen; Trevor G Smart
Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists.
The Journal of physiology 2004;557(Pt 2):389-413.
2004: Mette Brunsgaard Hermit; Jeremy R Greenwood; Birgitte Nielsen; Lennart Bunch; Charlotte G Jørgensen; Henrik T Vestergaard; Tine B Stensbøl; Connie Sanchez; Povl Krogsgaard-Larsen; Ulf Madsen; Hans Bräuner-Osborne
Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.
European journal of pharmacology 2004;486(3):241-50.
2004: Birgitte H Kaae; Povl Krogsgaard-Larsen; Tommy N Johansen
Synthesis of aryl- and heteroaryl-substituted 3-benzyloxyisothiazoles via Suzuki and Negishi cross-coupling reactions.
The Journal of organic chemistry 2004;69(4):1401-4.
2004: Stine B Vogensen; Jeremy R Greenwood; Annemarie R Varming; Lotte Brehm; Darryl S Pickering; Birgitte Nielsen; Tommy Liljefors; Rasmus P Clausen; Tommy N Johansen; Povl Krogsgaard-Larsen
A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.
Organic & biomolecular chemistry 2004;2(2):206-13.
2003: Dorte Krehan; Bente Frølund; Bjarke Ebert; Birgitte Nielsen; Povl Krogsgaard-Larsen; Graham A R Johnston; Mary Chebib
Aza-THIP and related analogues of THIP as GABA C antagonists.
Bioorganic & medicinal chemistry 2003;11(23):4891-6.
2003: Tim J Brier; Ian R Mellor; Denis B Tikhonov; Ioana Neagoe; Zuoyi Shao; Matt J Brierley; Kristian Strømgaard; Jerzy W Jaroszewski; Povl Krogsgaard-Larsen; Peter N R Usherwood
Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors.
Molecular pharmacology 2003;64(4):954-64.
2003: Anders A Jensen; Ivan Mikkelsen; Bente Frølund; Hans Bräuner-Osborne; Erik Falch; Povl Krogsgaard-Larsen
Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors.
Molecular pharmacology 2003;64(4):865-75.
2003: Jon Valgeirsson; Jeppe K Christensen; Anders Skov Kristensen; Darryl S Pickering; Birgitte Nielsen; Christina H Fischer; Hans Bräuner-Osborne; Elsebet Ø Nielsen; Povl Krogsgaard-Larsen; Ulf Madsen
Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues.
Bioorganic & medicinal chemistry 2003;11(20):4341-9.
2003: Alan Sarup; Orla M Larsson; Tina Bolvig; Bente Frølund; Povl Krogsgaard-Larsen; Arne Schousboe
Effects of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazol (exo-THPO) and its N-substituted analogs on GABA transport in cultured neurons and astrocytes and by the four cloned mouse GABA transporters.
Neurochemistry international 2003;43(4-5):445-51.
2003: Dorte Krehan; Bente Frølund; Povl Krogsgaard-Larsen; Jan Kehler; Graham A R Johnston; Mary Chebib
Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists.
Neurochemistry international 2003;42(7):561-5.
2003: Lotte Brehm; Jeremy R Greenwood; Kasper B Hansen; Birgitte Nielsen; Jan Egebjerg; Tine B Stensbøl; Hans Bräuner-Osborne; Frank A Sløk; Tine T A Kronborg; Povl Krogsgaard-Larsen
(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.
Journal of medicinal chemistry 2003;46(8):1350-8.
2003: Bente Frølund; Lena Tagmose; Anne T Jørgensen; Uffe Kristiansen; Tine B Stensbøl; Tommy Liljefors; Povl Krogsgaard-Larsen
Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABA A antagonists.
European journal of medicinal chemistry 2003;38(4):447-9.
2003: Lennart Bunch; Tommy Liljefors; Jeremy R Greenwood; Karla Frydenvang; Hans Bräuner-Osborne; Povl Krogsgaard-Larsen; Ulf Madsen
Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue.
The Journal of organic chemistry 2003;68(4):1489-95.
2003: Tommy N Johansen; Jeremy R Greenwood; Karla Frydenvang; Ulf Madsen; Povl Krogsgaard-Larsen
Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors.
Chirality 2003;15(2):167-79.
2003: Ian R Mellor; Tim J Brier; Florentina Pluteanu; Kristian Strømgaard; A Saghyan; N Eldursi; Matt J Brierley; Kim Andersen; Jerzy W Jaroszewski; Povl Krogsgaard-Larsen; Peter N R Usherwood
Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors.
Neuropharmacology 2003;44(1):70-80.
2003: Morten Muhlig Nielsen; Tommy Liljefors; Povl Krogsgaard-Larsen; Jan Egebjerg
The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741.
Molecular pharmacology 2003;63(1):19-25.
2002: Hasse Kromann; Sonata Krikstolaityte; Anne J Andersen; Kim Andersen; Povl Krogsgaard-Larsen; Jerzy W Jaroszewski; Jan Egebjerg; Kristian Strømgaard
Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors.
Journal of medicinal chemistry 2002;45(26):5745-54.
2002: Martin Mortensen; Bente Frølund; Anne T Jørgensen; Tommy Liljefors; Povl Krogsgaard-Larsen; Bjarke Ebert
Activity of novel 4-PIOL analogues at human alpha 1 beta 2 gamma 2S GABA(A) receptors--correlation with hydrophobicity.
European journal of pharmacology 2002;451(2):125-32.
2002: Rasmus P Clausen; Hans Bräuner-Osborne; Jeremy R Greenwood; Mette Brunsgaard Hermit; Tine B Stensbøl; Birgitte Nielsen; Povl Krogsgaard-Larsen
Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.
Journal of medicinal chemistry 2002;45(19):4240-5.
2002: Bente Frølund; Bjarke Ebert; Uffe Kristiansen; Tommy Liljefors; Povl Krogsgaard-Larsen
GABA(A) receptor ligands and their therapeutic potentials.
Current topics in medicinal chemistry 2002;2(8):817-32.
2002: H White; Alan Sarup; Tina Bolvig; Anders Skov Kristensen; Gitte Petersen; Nathan Nelson; Darryl S Pickering; Orla M Larsson; Bente Frølund; Povl Krogsgaard-Larsen; Arne Schousboe
Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs.
The Journal of pharmacology and experimental therapeutics 2002;302(2):636-44.
2002: Tommy N Johansen; Yves L Janin; Birgitte Nielsen; Karla Frydenvang; Hans Bräuner-Osborne; Tine B Stensbøl; Stine B Vogensen; Ulf Madsen; Povl Krogsgaard-Larsen
2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors.
Bioorganic & medicinal chemistry 2002;10(7):2259-66.
2002: Bente Frølund; Anne T Jørgensen; Lena Tagmose; Tine B Stensbøl; Henrik T Vestergaard; Christine Engblom; Uffe Kristiansen; Connie Sanchez; Povl Krogsgaard-Larsen; Tommy Liljefors
Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.
Journal of medicinal chemistry 2002;45(12):2454-68.
2002: Mette Guldbrandt; Tommy N Johansen; Karla Frydenvang; Hans Bräuner-Osborne; Tine B Stensbøl; Birgitte Nielsen; Rolf Karla; Flavio Santi; Povl Krogsgaard-Larsen; Ulf Madsen
Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs.
Chirality 2002;14(4):351-63.
2002: Kristian Strømgaard; Ian R Mellor; Kim Andersen; Ioana Neagoe; Florentina Pluteanu; Peter N R Usherwood; Povl Krogsgaard-Larsen; Jerzy W Jaroszewski
Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist.
Bioorganic & medicinal chemistry letters 2002;12(8):1159-62.
2002: Lennart Bunch; Povl Krogsgaard-Larsen; Ulf Madsen
Regioselective lithiation and functionalization of 3-(benzyloxy)isothiazole: application to the synthesis of thioibotenic acid.
The Journal of organic chemistry 2002;67(7):2375-7.
2002: Hasse Kromann; Frank A Sløk; Tine B Stensbøl; Hans Bräuner-Osborne; Ulf Madsen; Povl Krogsgaard-Larsen
Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids.
Journal of medicinal chemistry 2002;45(4):988-91.
2002: Tine B Stensbøl; Peter Uhlmann; Sandrine Morel; Birgitte L Eriksen; Jakob Felding; Hasse Kromann; Mette Brunsgaard Hermit; Jeremy R Greenwood; Hans Braüner-Osborne; Ulf Madsen; Finn Junager; Povl Krogsgaard-Larsen; Mikael Begtrup; Per Vedsø
Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology.
Journal of medicinal chemistry 2002;45(1):19-31.
2002: Povl Krogsgaard-Larsen; Bente Frølund; Tommy Liljefors
Specific GABA(A) agonists and partial agonists.
Chemical record (New York, N.Y.) 2002;2(6):419-30.
2002: Tine B Stensbøl; Ulf Madsen; Povl Krogsgaard-Larsen
The AMPA receptor binding site: focus on agonists and competitive antagonists.
Current pharmaceutical design 2002;8(10):857-72.
2001: Kristian Strømgaard; Kim Andersen; Povl Krogsgaard-Larsen; Jerzy W Jaroszewski
Recent advances in the medicinal chemistry of polyamine toxins.
Mini reviews in medicinal chemistry 2001;1(4):317-38.
2001: Ulf Madsen; Tine B Stensbøl; Povl Krogsgaard-Larsen
Inhibitors of AMPA and kainate receptors.
Current medicinal chemistry 2001;8(11):1291-301.
2001: Bjarke Ebert; M Mortensen; S A Thompson; Jan Kehler; Keith A Wafford; Povl Krogsgaard-Larsen
Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABA(A) receptors.
Bioorganic & medicinal chemistry letters 2001;11(12):1573-7.
2001: Hans Bräuner-Osborne; Anders A Jensen; PO Sheppard; B Brodin; Povl Krogsgaard-Larsen; PJ O'Hara
Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D.
Biochimica et biophysica acta 2001;1518(3):237-48.
2001: Anders A Jensen; B E Madsen; Povl Krogsgaard-Larsen; Hans Bräuner-Osborne
Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor.
European journal of pharmacology 2001;417(3):177-80.
2001: Lennart Bunch; T H Johansen; Hans Bräuner-Osborne; Tine B Stensbøl; Tommy N Johansen; Povl Krogsgaard-Larsen; Ulf Madsen
Synthesis and receptor binding affinity of new selective GluR5 ligands.
Bioorganic & medicinal chemistry 2001;9(4):875-9.
2001: Ulf Madsen; Hans Bräuner-Osborne; Karla Frydenvang; L Hvene; Tommy N Johansen; Birgitte Nielsen; C Sánchez; Tine B Stensbøl; F Bischoff; Povl Krogsgaard-Larsen
Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors.
Journal of medicinal chemistry 2001;44(7):1051-9.
2001: Lennart Bunch; P O Norrby; Karla Frydenvang; Povl Krogsgaard-Larsen; Ulf Madsen
Unprecedented migration of N-alkoxycarbonyl groups in protected pyroglutaminol.
Organic letters 2001;3(3):433-5.
2001: U S Sørensen; Erik Falch; Tine B Stensbøl; Jerzy W Jaroszewski; Ulf Madsen; Povl Krogsgaard-Larsen
Structural determinants for AMPA agonist activity of aryl or heteroaryl substituted AMPA analogues. Synthesis and pharmacology.
Archiv der Pharmazie 2001;334(2):62-8.
2001: Tine B Stensbøl; Henrik Sindal Jensen; Birgitte Nielsen; Tommy N Johansen; Jan Egebjerg; Karla Frydenvang; Povl Krogsgaard-Larsen
Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist.
European journal of pharmacology 2001;411(3):245-53.
2001: Tommy N Johansen; Tine B Stensbøl; Birgitte Nielsen; Stine B Vogensen; Karla Frydenvang; Frank A Sløk; H Bräüner-Osborne; Ulf Madsen; Povl Krogsgaard-Larsen
Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.
Chirality 2001;13(9):523-32.
2000: Bente Frølund; Lena Tagmose; Tommy Liljefors; Tine B Stensbøl; C Engblom; Uffe Kristiansen; Povl Krogsgaard-Larsen
A novel class of potent 3-isoxazolol GABA(A) antagonists: design, synthesis, and pharmacology.
Journal of medicinal chemistry 2000;43(26):4930-3.
2000: Benny Bang-Andersen; H Ahmadian; S M Lenz; Tine B Stensbøl; Ulf Madsen; Klaus P Bøgesø; Povl Krogsgaard-Larsen
Structural determinants of AMPA agonist activity in analogues of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid: synthesis and pharmacology.
Journal of medicinal chemistry 2000;43(25):4910-8.
2000: Kristian Strømgaard; Tim J Brier; Kim Andersen; Ian R Mellor; A Saghyan; Denis B Tikhonov; Peter N R Usherwood; Povl Krogsgaard-Larsen; Jerzy W Jaroszewski
Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues.
Journal of medicinal chemistry 2000;43(23):4526-33.
2000: Stine B Vogensen; Henrik Sindal Jensen; Tine B Stensbøl; Karla Frydenvang; Benny Bang-Andersen; Tommy N Johansen; Jan Egebjerg; Povl Krogsgaard-Larsen
Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist.
Chirality 2000;12(10):705-13.
2000: Hans Bräuner-Osborne; Mette Brunsgaard Hermit; Birgitte Nielsen; Povl Krogsgaard-Larsen; Tommy N Johansen
A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2.
European journal of pharmacology 2000;406(1):41-4.
2000: Anders A Jensen; Tracy A Spalding; Ethan S Burstein; PO Sheppard; PJ O'Hara; Mark R Brann; Povl Krogsgaard-Larsen; Hans Bräuner-Osborne
Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor.
The Journal of biological chemistry 2000;275(38):29547-55.
2000: Povl Krogsgaard-Larsen; Bente Frølund; Karla Frydenvang
GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.
Current pharmaceutical design 2000;6(12):1193-209.
2000: Hans Bräuner-Osborne; Jan Egebjerg; Elsebet O Nielsen; Ulf Madsen; Povl Krogsgaard-Larsen
Ligands for glutamate receptors: design and therapeutic prospects.
Journal of medicinal chemistry 2000;43(14):2609-45.
2000: Anders A Jensen; PO Sheppard; PJ O'Hara; Povl Krogsgaard-Larsen; Hans Bräuner-Osborne
The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity.
European journal of pharmacology 2000;397(2-3):247-53.
2000: Hans Bräuner-Osborne; Povl Krogsgaard-Larsen
Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain.
Genomics 2000;65(2):121-8.
2000: U S Sørensen; Erik Falch; Povl Krogsgaard-Larsen
A novel route to 5-substituted 3-isoxazolols. Cyclization of N, O-DiBoc beta-keto hydroxamic acids synthesized via acyl Meldrum's acids.
The Journal of organic chemistry 2000;65(4):1003-7.
2000: Kristian Strømgaard; Inga Bjørnsdottir; Kim Andersen; Matt J Brierley; S Rizoli; N Eldursi; Ian R Mellor; Peter N R Usherwood; Steen H Hansen; Povl Krogsgaard-Larsen; Jerzy W Jaroszewski
Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12.
Chirality 2000;12(2):93-102.
2000: Nicolai Stuhr-Hansen; Bjarke Ebert; Povl Krogsgaard-Larsen; Jan Kehler
Synthesis and pharmacology of seleninic acid analogues of the inhibitory neurotransmitter gamma-aminobutyric acid.
Organic letters 2000;2(1):7-9.
2000: Ulf Madsen; Frank A Sløk; Tine B Stensbøl; Hans Bräuner-Osborne; H H Lützhøft; M V Poulsen; L Eriksen; Povl Krogsgaard-Larsen
Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist.
European journal of medicinal chemistry 2000;35(1):69-76.
1999: Erik Falch; Jens Perregaard; B FrŁlund; B SŁkilde; Anders Buur; L M Hansen; Karla Frydenvang; Lotte Brehm; Tina Bolvig; Orla M Larsson; Connie Sanchez; H White; Arne Schousboe; Povl Krogsgaard-Larsen
Selective inhibitors of glial GABA uptake: synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues.
Journal of medicinal chemistry 1999;42(26):5402-14.
1999: K Stromgaard; Matt J Brierley; Kim Andersen; Frank A Sløk; Ian R Mellor; Peter N R Usherwood; Povl Krogsgaard-Larsen; Jerzy W Jaroszewski
Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor.
Journal of medicinal chemistry 1999;42(25):5224-34.
1999: Hans Bräuner-Osborne; Povl Krogsgaard-Larsen
Functional pharmacology of cloned heterodimeric GABAB receptors expressed in mammalian cells.
British journal of pharmacology 1999;128(7):1370-4.
1999: Tina Bolvig; Orla M Larsson; Darryl S Pickering; N Nelson; Erik Falch; Povl Krogsgaard-Larsen; Arne Schousboe
Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity.
European journal of pharmacology 1999;375(1-3):367-74.
1999: Hans Bräuner-Osborne; Anders A Jensen; PO Sheppard; PJ O'Hara; Povl Krogsgaard-Larsen
The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain.
The Journal of biological chemistry 1999;274(26):18382-6.
1999: Tine B Stensbøl; Frank A Sløk; J Trometer; S Hurt; Bjarke Ebert; C Kjøller; Jan Egebjerg; Ulf Madsen; Nils Henrik Diemer; Povl Krogsgaard-Larsen
Characterization of a new AMPA receptor radioligand, [3H]2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid.
European journal of pharmacology 1999;373(2-3):251-62.
1999: R Karla; Bjarke Ebert; C Thorkildsen; C Herdeis; Tommy N Johansen; Birgitte Nielsen; Povl Krogsgaard-Larsen
Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4-chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4-chlorophenyl)pentanoic acid.
Journal of medicinal chemistry 1999;42(11):2053-9.
1999: H Pedersen; Hans Bräuner-Osborne; R G Ball; Karla Frydenvang; E Meier; Klaus P Bøgesø; Povl Krogsgaard-Larsen
Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine bioisosteres of arecoline.
Bioorganic & medicinal chemistry 1999;7(5):795-809.
1999: Bjarke Ebert; B Frølund; Nils Henrik Diemer; Povl Krogsgaard-Larsen
Equilibrium binding characteristics of [3H]thiomuscimol.
Neurochemistry international 1999;34(5):427-34.
1999: Jan Kehler; Tine B Stensbøl; Povl Krogsgaard-Larsen
Piperidinyl-3-phosphinic acids as novel uptake inhibitors of the neurotransmitter gamma-aminobutyric acid (GABA).
Bioorganic & medicinal chemistry letters 1999;9(6):811-4.
1999: E H Møller; Jan Egebjerg; Lotte Brehm; Tine B Stensbøl; Tommy N Johansen; Ulf Madsen; Povl Krogsgaard-Larsen
Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1-4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.
Chirality 1999;11(10):752-9.
1998: Erik Falch; Lotte Brehm; Ivan Mikkelsen; Tommy N Johansen; N Skjaerbaek; Birgitte Nielsen; Tine B Stensbøl; Bjarke Ebert; Povl Krogsgaard-Larsen
Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships.
Journal of medicinal chemistry 1998;41(14):2513-23.
1998: Hans Bräuner-Osborne; Birgitte Nielsen; Povl Krogsgaard-Larsen
Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors.
European journal of pharmacology 1998;350(2-3):311-6.
1998: Tommy N Johansen; Bjarke Ebert; Hans Bräuner-Osborne; Michael Didriksen; I T Christensen; Karina Krøjer Søby; Ulf Madsen; Povl Krogsgaard-Larsen; Lotte Brehm
Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.
Journal of medicinal chemistry 1998;41(6):930-9.
1998: Povl Krogsgaard-Larsen; Bente Frølund; Erik Falch
Inhibitors of gamma-aminobutyric acid transport as experimental tools and therapeutic agents.
Methods in enzymology 1998;296():165-75.
1998: N Skjaerbaek; Lotte Brehm; Tommy N Johansen; L M Hansen; Birgitte Nielsen; Bjarke Ebert; Karina Krøjer Søby; Tine B Stensbøl; Erik Falch; Povl Krogsgaard-Larsen
Aryl and cycloalkyl analogues of AMPA: synthetic, pharmacological and stereochemical aspects.
Bioorganic & medicinal chemistry 1998;6(1):119-31.
1998: Hans Bräuner-Osborne; Povl Krogsgaard-Larsen
Pharmacology of (S)-homoquisqualic acid and (S)-2-amino-5-phosphonopentanoic acid [(S)-AP5] at cloned metabotropic glutamate receptors.
British journal of pharmacology 1998;123(2):269-74.
1997: H Ahmadian; Birgitte Nielsen; Hans Bräuner-Osborne; Tommy N Johansen; Tine B Stensbøl; Frank A Sløk; N Sekiyama; S Nakanishi; Povl Krogsgaard-Larsen; Ulf Madsen
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.
Journal of medicinal chemistry 1997;40(22):3700-5.
1997: H Bráuner-Osborne; Birgitte Nielsen; Tine B Stensbøl; Tommy N Johansen; N Skjaerbaek; Povl Krogsgaard-Larsen
Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors.
European journal of pharmacology 1997;335(2-3):R1-3.
1997: Benny Bang-Andersen; S M Lenz; N Skjaerbaek; Karina Krøjer Søby; H O Hansen; Bjarke Ebert; Klaus P Bøgesø; Povl Krogsgaard-Larsen
Heteroaryl analogues of AMPA. Synthesis and quantitative structure-activity relationships.
Journal of medicinal chemistry 1997;40(18):2831-42.
1997: L Matzen; Bjarke Ebert; Tine B Stensbøl; Bente Frølund; Jerzy W Jaroszewski; Povl Krogsgaard-Larsen
Bioisosterically modified dipeptide excitatory amino acid receptor antagonists containing 3-oxygenated isothiazole ring systems.
Bioorganic & medicinal chemistry 1997;5(8):1569-75.
1997: L Matzen; A Engesgaard; Bjarke Ebert; Michael Didriksen; Bente Frølund; Povl Krogsgaard-Larsen; Jerzy W Jaroszewski
AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid.
Journal of medicinal chemistry 1997;40(4):520-7.
1997: Tommy N Johansen; Karla Frydenvang; Bjarke Ebert; Ulf Madsen; Povl Krogsgaard-Larsen
Excitatory amino acid receptor antagonists: resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA).
Chirality 1997;9(5-6):529-36.
1997: Tommy N Johansen; Bjarke Ebert; Erik Falch; Povl Krogsgaard-Larsen
AMPA receptor agonists: resolution, configurational assignment, and pharmacology of (+)-(S)- and (-)-(R)-2-amino-3-[3-hydroxy-5-(2-pyridyl)-isoxazol-4-yl]-propionic acid (2-Py-AMPA).
Chirality 1997;9(3):274-80.
1996: Hans Bräuner-Osborne; Bjarke Ebert; Mark R Brann; Erik Falch; Povl Krogsgaard-Larsen
Functional partial agonism at cloned human muscarinic acetylcholine receptors.
European journal of pharmacology 1996;313(1-2):145-50.
1996: Bjarke Ebert; Ulf Madsen; Karina Krøjer Søby; Povl Krogsgaard-Larsen
Functional partial agonism at ionotropic excitatory amino acid receptors.
Neurochemistry international 1996;29(3):309-16.
1996: Hans Bräuner-Osborne; Frank A Sløk; N Skjaerbaek; Bjarke Ebert; N Sekiyama; S Nakanishi; Povl Krogsgaard-Larsen
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.
Journal of medicinal chemistry 1996;39(16):3188-94.
1996: Ulf Madsen; B Bang-Andersen; Lotte Brehm; I T Christensen; Bjarke Ebert; I T Kristoffersen; Y Lang; Povl Krogsgaard-Larsen
Synthesis and pharmacology of highly selective carboxy and phosphono isoxazole amino acid AMPA receptor antagonists.
Journal of medicinal chemistry 1996;39(8):1682-91.
1996: B Søkilde; I Mikkelsen; Tine B Stensbøl; B Andersen; S Ebdrup; Povl Krogsgaard-Larsen; Erik Falch
Analogues of carbacholine: synthesis and relationship between structure and affinity for muscarinic and nicotinic acetylcholine receptors.
Archiv der Pharmazie 1996;329(2):95-104.
1996: Jerzy W Jaroszewski; L Matzen; Bente Frølund; Povl Krogsgaard-Larsen
Neuroactive polyamine wasp toxins: nuclear magnetic resonance spectroscopic analysis of the protolytic properties of philanthotoxin-343.
Journal of medicinal chemistry 1996;39(2):515-21.
1996: Ulf Madsen; Karla Frydenvang; Bjarke Ebert; Tommy N Johansen; Lotte Brehm; Povl Krogsgaard-Larsen
N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
Journal of medicinal chemistry 1996;39(1):183-90.
1995: Bente Frølund; U Kristiansen; Lotte Brehm; A B Hansen; Povl Krogsgaard-Larsen; Erik Falch
Partial GABAA receptor agonists. Synthesis and in vitro pharmacology of a series of nonannulated analogs of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol.
Journal of medicinal chemistry 1995;38(17):3287-96.
1995: Hans Bräuner-Osborne; Bjarke Ebert; Mark R Brann; Erik Falch; Povl Krogsgaard-Larsen
Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors.
Journal of medicinal chemistry 1995;38(12):2188-95.
1995: F Bischoff; Tommy N Johansen; Bjarke Ebert; Povl Krogsgaard-Larsen; Ulf Madsen
Excitatory amino acid receptor ligands: asymmetric synthesis, absolute stereochemistry and pharmacology of (R)- and (S)-homoibotenic acid.
Bioorganic & medicinal chemistry 1995;3(5):553-8.
1995: Bjarke Ebert; S Andersen; Povl Krogsgaard-Larsen
Ketobemidone, methadone and pethidine are non-competitive N-methyl-D-aspartate (NMDA) antagonists in the rat cortex and spinal cord.
Neuroscience letters 1995;187(3):165-8.
1995: Bente Frølund; L Jeppesen; Povl Krogsgaard-Larsen; J J Hansen
GABAA agonists: resolution and pharmacology of (+)- and (-)-isoguvacine oxide.
Chirality 1995;7(6):434-8.
1994: Bjarke Ebert; K A Wafford; Paul J Whiting; Povl Krogsgaard-Larsen; J A Kemp
Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.
Molecular pharmacology 1994;46(5):957-63.
1994: Tommy N Johansen; Karla Frydenvang; Bjarke Ebert; Povl Krogsgaard-Larsen; Ulf Madsen
Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands.
Journal of medicinal chemistry 1994;37(20):3252-62.
1994: Povl Krogsgaard-Larsen; Bente Frølund; Flemming Steen Jørgensen; A Schousboe
GABAA receptor agonists, partial agonists, and antagonists. Design and therapeutic prospects.
Journal of medicinal chemistry 1994;37(16):2489-505.
1994: Bjarke Ebert; Ulf Madsen; T M Lund; S M Lenz; Povl Krogsgaard-Larsen
Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA.
Neurochemistry international 1994;24(6):507-15.
1994: Bjarke Ebert; S Lenz; Lotte Brehm; P Bregnedal; J J Hansen; K Frederiksen; K P Bøgesø; Povl Krogsgaard-Larsen
Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA].
Journal of medicinal chemistry 1994;37(7):878-84.
1994: Karla Frydenvang; J J Hansen; Povl Krogsgaard-Larsen; A Mitrovic; H Tran; C A Drew; G A Johnston
GABAB antagonists: resolution, absolute stereochemistry, and pharmacology of (R)- and (S)-phaclofen.
Chirality 1994;6(7):583-9.
1993: Povl Krogsgaard-Larsen; P Wahl; A Schousboe; Ulf Madsen; J J Hansen
Excitatory amino acid research in Alzheimer's disease: enhancement and blockade of receptor functions.
Biochemical Society transactions 1993;21(1):102-6.
1993: Ulf Madsen; Bjarke Ebert; J J Hansen; Povl Krogsgaard-Larsen
The non-depolarizing D-form of bromohomoibotenic acid enhances depolarizations evoked by the L-form or quisqualate.
European journal of pharmacology 1993;230(3):383-6.
1993: A Lagersted; Erik Falch; Bjarke Ebert; Povl Krogsgaard-Larsen
Conformational aspects of the muscarinic receptor interactions of bicyclic isoxazole ester bioisosteres of arecoline.
Drug design and discovery 1993;9(3-4):237-50.
1993: J R Buur; H Hjeds; Povl Krogsgaard-Larsen; Flemming Steen Jørgensen
Conformational analysis and molecular modelling of a partial GABAA agonist and a glycine antagonist related to the GABAA agonist, THIP.
Drug design and discovery 1993;10(3):213-29.
1992: Povl Krogsgaard-Larsen; J J Hansen
Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design.
Toxicology letters 1992;64-65 Spec No():409-16.
1992: P Wahl; B Nielsen; Povl Krogsgaard-Larsen; J J Hansen; A Schousboe; R Miledi
Stereoselective effects of AMOA on non-NMDA receptors expressed in Xenopus oocytes.
Journal of neuroscience research 1992;33(3):392-7.
1992: I T Christensen; Bjarke Ebert; Ulf Madsen; Birgitte Nielsen; Lotte Brehm; Povl Krogsgaard-Larsen
Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid.
Journal of medicinal chemistry 1992;35(19):3512-9.
1992: U Kristiansen; A Hedegaard; C Herdeis; T M Lund; Birgitte Nielsen; J J Hansen; Erik Falch; H Hjeds; Povl Krogsgaard-Larsen
Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships.
Journal of neurochemistry 1992;58(3):1150-9.
1992: Povl Krogsgaard-Larsen
GABA and glutamate receptors as therapeutic targets in neurodegenerative disorders.
Pharmacology & toxicology 1992;70(2):95-104.
1991: Bjarke Ebert; E H Wong; Povl Krogsgaard-Larsen
Identification of a novel NMDA receptor in rat cerebellum.
European journal of pharmacology 1991;208(1):49-52.
1991: U Kristiansen; J D Lambert; Erik Falch; Povl Krogsgaard-Larsen
Electrophysiological studies of the GABAA receptor ligand, 4-PIOL, on cultured hippocampal neurones.
British journal of pharmacology 1991;104(1):85-90.
1991: Bjarke Ebert; Ulf Madsen; Tommy N Johansen; Povl Krogsgaard-Larsen
NMDA receptor agonists: relationships between structure and biological activity.
Advances in experimental medicine and biology 1991;287():483-7.
1991: Povl Krogsgaard-Larsen; J W Ferkany; E O Nielsen; Ulf Madsen; Bjarke Ebert; J S Johansen; N H Diemer; T Bruhn; D T Beattie; D R Curtis
Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection.
Journal of medicinal chemistry 1991;34(1):123-30.
1990: Ulf Madsen; J W Ferkany; B E Jones; Bjarke Ebert; Tommy N Johansen; T Holm; Povl Krogsgaard-Larsen
NMDA receptor agonists derived from ibotenic acid. Preparation, neuroexcitation and neurotoxicity.
European journal of pharmacology 1990;189(6):381-91.
1990: A Frandsen; Povl Krogsgaard-Larsen; A Schousboe
Novel glutamate receptor antagonists selectively protect against kainic acid neurotoxicity in cultured cerebral cortex neurons.
Journal of neurochemistry 1990;55(5):1821-3.
1990: Ulf Madsen; E O Nielsen; D R Curtis; D T Beattie; Povl Krogsgaard-Larsen
Synthesis and single cell pharmacology of potential heterocyclic bioisosteres of the excitatory amino acid antagonist glutamic acid diethyl ester.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) 1990;44(1):96-102.
1990: J J Hansen; Birgitte Nielsen; A Reinhardt; Povl Krogsgaard-Larsen
Excitatory amino acid receptor agonists. Enantiomeric resolutions by use of enzymes and chiral HPLC.
Acta pharmaceutica Nordica 1990;2(3):185-92.
1990: J J Hansen; Povl Krogsgaard-Larsen
Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors.
Medicinal research reviews 1990;10(1):55-94.
1990: L Nielsen; Lotte Brehm; Povl Krogsgaard-Larsen
GABA agonists and uptake inhibitors. Synthesis, absolute stereochemistry, and enantioselectivity of (R)-(-)- and (S)-(+)-homo-beta-proline.
Journal of medicinal chemistry 1990;33(1):71-7.
1990: Ulf Madsen; Lotte Brehm; K Schaumburg; F S Jørgensen; Povl Krogsgaard-Larsen
Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors.
Journal of medicinal chemistry 1990;33(1):374-80.
1989: J J Hansen; Birgitte Nielsen; Povl Krogsgaard-Larsen; Lotte Brehm; E O Nielsen; D R Curtis
Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid.
Journal of medicinal chemistry 1989;32(10):2254-60.
1989: Erik Falch; Povl Krogsgaard-Larsen
GABA uptake inhibitors containing mono- and diarylmethoxyalkyl N-substituents.
Drug design and delivery 1989;4(3):205-15.
1989: E O Nielsen; M Aarslew-Jensen; N H Diemer; Povl Krogsgaard-Larsen; A Schousboe
Baclofen-induced, calcium-dependent stimulation of in vivo release of D-[3H]aspartate from rat hippocampus monitored by intracerebral microdialysis.
Neurochemical research 1989;14(4):321-6.
1988: P Sauerberg; Erik Falch; E Meier; H L Lembøl; Povl Krogsgaard-Larsen
Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres.
Journal of medicinal chemistry 1988;31(7):1312-6.
1988: Povl Krogsgaard-Larsen; Erik Falch; P Sauerberg; S B Freedman; H L Lembøl; E Meier
Bioisosteres of arecoline as novel CNS-active muscarinic agonists.
Trends in pharmacological sciences 1988;Suppl():69-74.
1988: Povl Krogsgaard-Larsen
GABA synaptic mechanisms: stereochemical and conformational requirements.
Medicinal research reviews 1988;8(1):27-56.
1987: Erik Falch; B S Meldrum; Povl Krogsgaard-Larsen
GABA uptake inhibitors. Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid.
Drug design and delivery 1987;2(1):9-21.
1987: J R Byberg; I M Labouta; Erik Falch; H Hjeds; Povl Krogsgaard-Larsen; D R Curtis; B D Gynther
Synthesis and biological activity of a GABAA agonist which has no effect on benzodiazepine binding and of structurally related glycine antagonists.
Drug design and delivery 1987;1(4):261-74.
1987: Povl Krogsgaard-Larsen; Erik Falch; O M Larsson; A Schousboe
GABA uptake inhibitors: relevance to antiepileptic drug research.
Epilepsy research 1987;1(2):77-93.
1986: P Sauerberg; B Fjalland; J J Larsen; T Bach-Lauritsen; Erik Falch; Povl Krogsgaard-Larsen
Pharmacological profile of a novel class of muscarinic acetylcholine receptor agonists.
European journal of pharmacology 1986;130(1-2):125-31.
1986: Erik Falch; A Hedegaard; L Nielsen; B R Jensen; H Hjeds; Povl Krogsgaard-Larsen
Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.
Journal of neurochemistry 1986;47(3):898-903.
1986: P Sauerberg; J J Larsen; Erik Falch; Povl Krogsgaard-Larsen
A novel class of conformationally restricted heterocyclic muscarinic agonists.
Journal of medicinal chemistry 1986;29(6):1004-9.
1986: Ulf Madsen; K Schaumburg; Lotte Brehm; D R Curtis; Povl Krogsgaard-Larsen
Ibotenic acid analogues. Synthesis and biological testing of two bicyclic 3-isoxazolol amino acids.
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 1986;40(2):92-7.
1986: Lotte Brehm; Povl Krogsgaard-Larsen; K Schaumburg; J S Johansen; Erik Falch; D R Curtis
Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions.
Journal of medicinal chemistry 1986;29(2):224-9.
1985: Povl Krogsgaard-Larsen; Lotte Brehm; J S Johansen; P Vinzents; J Lauridsen; D R Curtis
Synthesis and structure-activity studies on excitatory amino acids structurally related to ibotenic acid.
Journal of medicinal chemistry 1985;28(5):673-9.
1985: J Lauridsen; T Honoré; Povl Krogsgaard-Larsen
Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors.
Journal of medicinal chemistry 1985;28(5):668-72.
1985: Arne Schousboe; O M Larsson; Povl Krogsgaard-Larsen
Lack of a high affinity uptake system for the GABA agonists THIP and isoguvacine in neurons and astrocytes cultured from mouse brain.
Neurochemistry international 1985;7(3):505-8.
1985: Erik Falch; P Jacobsen; Povl Krogsgaard-Larsen; D R Curtis
GABA-mimetic activity and effects on diazepam binding of aminosulphonic acids structurally related to piperidine-4-sulphonic acid.
Journal of neurochemistry 1985;44(1):68-75.
1985: Povl Krogsgaard-Larsen; Erik Falch; H Hjeds
Heterocyclic analogues of GABA: chemistry, molecular pharmacology and therapeutic aspects.
Progress in medicinal chemistry 1985;22():67-120.
1984: Povl Krogsgaard-Larsen; E O Nielsen; D R Curtis
Ibotenic acid analogues. Synthesis and biological and in vitro activity of conformationally restricted agonists at central excitatory amino acid receptors.
Journal of medicinal chemistry 1984;27(5):585-91.
1983: Povl Krogsgaard-Larsen; H Mikkelsen; P Jacobsen; Erik Falch; D R Curtis; M J Peet; J D Leah
4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
Journal of medicinal chemistry 1983;26(6):895-900.
1983: J J Hansen; J Lauridsen; E Nielsen; Povl Krogsgaard-Larsen
Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid.
Journal of medicinal chemistry 1983;26(6):901-3.
1983: Povl Krogsgaard-Larsen; Erik Falch; M J Peet; J D Leah; D R Curtis
Molecular pharmacology of the GABA receptors and GABA agonists.
Advances in biochemical psychopharmacology 1983;37():1-13.
1982: Povl Krogsgaard-Larsen; H Hjeds; D R Curtis; J D Leah; M J Peet
Glycine antagonists structurally related to muscimol, THIP, or isoguvacine.
Journal of neurochemistry 1982;39(5):1319-24.
1982: P Jacobsen; I M Labouta; K Schaumburg; Erik Falch; Povl Krogsgaard-Larsen
Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors.
Journal of medicinal chemistry 1982;25(10):1157-62.
1982: Povl Krogsgaard-Larsen; J J Hansen; J Lauridsen; M J Peet; J D Leah; D R Curtis
Glutamic acid agonists. Stereochemical and conformational studies of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and related compounds.
Neuroscience letters 1982;31(3):313-7.
1982: T Honoré; J Lauridsen; Povl Krogsgaard-Larsen
The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes.
Journal of neurochemistry 1982;38(1):173-8.
1981: T Honoré; Povl Krogsgaard-Larsen; J J Hansen; J Lauridsen
Glutamate and aspartate agonists structurally related to ibotenic acid.
Molecular and cellular biochemistry 1981;38 Spec No(Pt 1):123-8.
1981: T Honoré; J Lauridsen; Povl Krogsgaard-Larsen
Ibotenic acid analogues as inhibitors of [3H]glutamic acid binding to cerebellar membranes.
Journal of neurochemistry 1981;36(3):1302-4.
1981: Povl Krogsgaard-Larsen; T Honoré; J J Hansen; D R Curtis; D Lodge
Structure-activity studies on ibotenic acid and related muscimol analogues.
Advances in biochemical psychopharmacology 1981;27():285-94.
1981: Povl Krogsgaard-Larsen; Lotte Brehm; K Schaumburg
Muscimol, a psychoactive constituent of Amanita muscaria, as a medicinal chemical model structure.
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 1981;35(5):311-24.
1980: Povl Krogsgaard-Larsen; T Honoré; J J Hansen; D R Curtis; D Lodge
New class of glutamate agonist structurally related to ibotenic acid.
Nature 1980;284(5751):64-6.