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Povl Krogsgaard-Larsen

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Co-Publications
Name
42
Madsen, Ulf
38
Ebert, Bjarke
35
Frølund, Bente
35
Bräuner-Osborne, Hans
34
Falch, Erik
33
Stensbøl, Tine
30
Nielsen, Birgitte
27
Johansen, Tommy
21
Brehm, Lotte
18
Frydenvang, Karla
16
Liljefors, Tommy
14
Clausen, Rasmus
13
Jaroszewski, Jerzy
12
Greenwood, Jeremy
11
Egebjerg, Jan

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Publications

TOP 3
Gottschalk Marie; Bach Anders; Hansen Jakob Lerche; Krogsgaard-Larsen Povl; Kristensen Anders S; Strømgaard Kristian
Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction.
Clausen Rasmus P; Naur Peter; Kristensen Anders S; Greenwood Jeremy R; Strange Mette; Bräuner-Osborne Hans; Jensen Anders A; Nielsen Anne Sophie T; Geneser Ulla; Ringgaard Lone M; Nielsen Birgitte; Pickering Darryl S; Brehm Lotte; Gajhede Michael; Krogsgaard-Larsen Povl; Kastrup Jette S
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.
Madsen Karsten K; Clausen Rasmus P; Larsson Orla M; Krogsgaard-Larsen Povl; Schousboe Arne; White H Steve
Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs.

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All Publications

2009: Gottschalk Marie; Bach Anders; Hansen Jakob Lerche; Krogsgaard-Larsen Povl; Kristensen Anders S; Strømgaard Kristian
Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction.
Neurochemical research 2009;34(10):1729-37.
2009: Clausen Rasmus P; Naur Peter; Kristensen Anders S; Greenwood Jeremy R; Strange Mette; Bräuner-Osborne Hans; Jensen Anders A; Nielsen Anne Sophie T; Geneser Ulla; Ringgaard Lone M; Nielsen Birgitte; Pickering Darryl S; Brehm Lotte; Gajhede Michael; Krogsgaard-Larsen Povl; Kastrup Jette S
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.
Journal of medicinal chemistry 2009;52(15):4911-22.
2009: Madsen Karsten K; Clausen Rasmus P; Larsson Orla M; Krogsgaard-Larsen Povl; Schousboe Arne; White H Steve
Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs.
Journal of neurochemistry 2009;109 Suppl 1():139-44.
2008: Smith Misty D; Saunders Gerald W; Clausen Rasmus P; Frølund Bente; Krogsgaard-Larsen Povl; Larsson Orla M; Schousboe Arne; Wilcox Karen S; White H Steve
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC).
Epilepsy research 2008;79(1):6-13.
2007: Madsen Christian; Jensen Anders A; Liljefors Tommy; Kristiansen Uffe; Nielsen Birgitte; Hansen Camilla P; Larsen Mogens; Ebert Bjarke; Bang-Andersen Benny; Krogsgaard-Larsen Povl; Frølund Bente
5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
Journal of medicinal chemistry 2007;50(17):4147-61.
2007: Vogensen Stine B; Frydenvang Karla; Greenwood Jeremy R; Postorino Giovanna; Nielsen Birgitte; Pickering Darryl S; Ebert Bjarke; Bølcho Ulrik; Egebjerg Jan; Gajhede Michael; Kastrup Jette S; Johansen Tommy N; Clausen Rasmus P; Krogsgaard-Larsen Povl
A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
Journal of medicinal chemistry 2007;50(10):2408-14.
2007: Jørgensen Charlotte G; Bräuner-Osborne Hans; Nielsen Birgitte; Kehler Jan; Clausen Rasmus P; Krogsgaard-Larsen Povl; Madsen Ulf
Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.
Bioorganic & medicinal chemistry 2007;15(10):3524-38.
2007: Frølund Bente; Jensen Lars S; Storustovu Signe I; Stensbøl Tine B; Ebert Bjarke; Kehler Jan; Krogsgaard-Larsen Povl; Liljefors Tommy
4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships.
Journal of medicinal chemistry 2007;50(8):1988-92.
2007: Jørgensen Charlotte G; Clausen Rasmus P; Hansen Kasper B; Bräuner-Osborne Hans; Nielsen Birgitte; Metzler Bjørn; Kehler Jan; Krogsgaard-Larsen Povl; Madsen Ulf
Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid.
Organic & biomolecular chemistry 2007;5(3):463-71.
2006: Clausen Rasmus P; Frølund Bente; Larsson Orla M; Schousboe Arne; Krogsgaard-Larsen Povl; White H Steve
A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS.
Neurochemistry international 2006;48(6-7):637-42.
2006: Krehan Dorte; Storustovu Signe I; Liljefors Tommy; Ebert Bjarke; Nielsen Birgitte; Krogsgaard-Larsen Povl; Frølund Bente
Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.
Journal of medicinal chemistry 2006;49(4):1388-96.
2006: Clausen Rasmus Praetorius; Madsen Karsten; Larsson Orla Miller; Frølund Bente; Krogsgaard-Larsen Povl; Schousboe Arne
Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors.
Advances in pharmacology (San Diego, Calif.) 2006;54():265-84.
2006: Krogsgaard-Larsen Povl; Frølund Bente; Liljefors Tommy
GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.
Advances in pharmacology (San Diego, Calif.) 2006;54():53-71.
2006: Høg Signe; Greenwood Jeremy R; Madsen Karsten B; Larsson Orla M; Frølund Bente; Schousboe Arne; Krogsgaard-Larsen Povl; Clausen Rasmus P
Structure-activity relationships of selective GABA uptake inhibitors.
Current topics in medicinal chemistry 2006;6(17):1861-82.
2005: Frølund Bente; Greenwood Jeremy R; Holm Mai M; Egebjerg Jan; Madsen Ulf; Nielsen Birgitte; Bräuner-Osborne Hans; Stensbøl Tine B; Krogsgaard-Larsen Povl
Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.
Bioorganic & medicinal chemistry 2005;13(18):5391-8.
2005: Jensen Anders A; Frølund Bente; Liljefors Tommy; Krogsgaard-Larsen Povl
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Journal of medicinal chemistry 2005;48(15):4705-45.
2005: Vogensen Stine B; Clausen Rasmus P; Greenwood Jeremy R; Johansen Tommy N; Pickering Darryl S; Nielsen Birgitte; Ebert Bjarke; Krogsgaard-Larsen Povl
Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.
Journal of medicinal chemistry 2005;48(9):3438-42.
2005: Couvreur Patrick; Barguer Diane; Crommelin Daan J A; Duchêne Dominique; Engels Joachim W; Kerr David J; Krogsgaard-Larsen Povl; Meijer Dirk K; Paoletti Rodolfo; Wagner Ernst;
EUFEPS report. Contribution of academic research to discovery and development of medicines: current status and future opportunities.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;24(2-3):245-52.
2005: Clausen Rasmus P; Moltzen Ejner K; Perregaard Jens; Lenz Sibylle M; Sanchez Connie; Falch Erik; Frølund Bente; Bolvig Tina; Sarup Alan; Larsson Orla M; Schousboe Arne; Krogsgaard-Larsen Povl
Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues.
Bioorganic & medicinal chemistry 2005;13(3):895-908.
2005: White H Steve; Watson William P; Hansen Suzanne L; Slough Scott; Perregaard Jens; Sarup Alan; Bolvig Tina; Petersen Gitte; Larsson Orla M; Clausen Rasmus P; Frølund Bente; Falch Erik; Krogsgaard-Larsen Povl; Schousboe Arne
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
The Journal of pharmacology and experimental therapeutics 2005;312(2):866-74.
2005: Frølund Bente; Jensen Lars S; Guandalini Luca; Canillo Carolina; Vestergaard Henrik T; Kristiansen Uffe; Nielsen Birgitte; Stensbøl Tine B; Madsen Christian; Krogsgaard-Larsen Povl; Liljefors Tommy
Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.
Journal of medicinal chemistry 2005;48(2):427-39.
2004: N'goka Victor; Stenbøl Tine B; Krogsgaard-Larsen Povl; Schlewer Gilbert
Synthesis and GABA uptake inhibitory properties of 6-aryl iminoxymethyl substituted nipecotic acids.
European journal of medicinal chemistry 2004;39(10):889-95.
2004: Krogsgaard-Larsen Povl; Frølund Bente; Liljefors Tommy; Ebert Bjarke
GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.
Biochemical pharmacology 2004;68(8):1573-80.
2004: Jensen Anders A; Mikkelsen Ivan; Frølund Bente; Frydenvang Karla; Brehm Lotte; Jaroszewski Jerzy W; Bräuner-Osborne Hans; Falch Erik; Krogsgaard-Larsen Povl
Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors.
European journal of pharmacology 2004;497(2):125-37.
2004: Brehm Lotte; Greenwood Jeremy R; Sløk Frank A; Holm Mai Marie; Nielsen Birgitte; Geneser Ulla; Stensbøl Tine B; Bräuner-Osborne Hans; Begtrup Mikael; Egebjerg Jan; Krogsgaard-Larsen Povl
Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA.
Chirality 2004;16(7):452-66.
2004: N'Goka Victor; Bissantz Caterina; Bisel Philippe; Stenbøl Tine B; Krogsgaard-Larsen Povl; Schlewer Gilbert
Syntheses and GABA uptake properties of 6-ether- and 6-enol ether-substituted nipecotic acids.
European journal of medicinal chemistry 2004;39(7):633-8.
2004: Mortensen Martin; Kristiansen Uffe; Ebert Bjarke; Frølund Bente; Krogsgaard-Larsen Povl; Smart Trevor G
Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists.
The Journal of physiology 2004;557(Pt 2):389-413.
2004: Hermit Mette B; Greenwood Jeremy R; Nielsen Birgitte; Bunch Lennart; Jørgensen Charlotte G; Vestergaard Henrik T; Stensbøl Tine B; Sanchez Connie; Krogsgaard-Larsen Povl; Madsen Ulf; Bräuner-Osborne Hans
Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.
European journal of pharmacology 2004;486(3):241-50.
2004: Kaae Birgitte H; Krogsgaard-Larsen Povl; Johansen Tommy N
Synthesis of aryl- and heteroaryl-substituted 3-benzyloxyisothiazoles via Suzuki and Negishi cross-coupling reactions.
The Journal of organic chemistry 2004;69(4):1401-4.
2004: Vogensen Stine B; Greenwood Jeremy R; Varming Annemarie R; Brehm Lotte; Pickering Darryl S; Nielsen Birgitte; Liljefors Tommy; Clausen Rasmus P; Johansen Tommy N; Krogsgaard-Larsen Povl
A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.
Organic & biomolecular chemistry 2004;2(2):206-13.
2003: Krehan Dorte; Frølund Bente; Ebert Bjarke; Nielsen Birgitte; Krogsgaard-Larsen Povl; Johnston Graham A R; Chebib Mary
Aza-THIP and related analogues of THIP as GABA C antagonists.
Bioorganic & medicinal chemistry 2003;11(23):4891-6.
2003: Brier Tim J; Mellor Ian R; Tikhonov Denis B; Neagoe Ioana; Shao Zuoyi; Brierley Matt J; Strømgaard Kristian; Jaroszewski Jerzy W; Krogsgaard-Larsen Povl; Usherwood Peter N R
Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors.
Molecular pharmacology 2003;64(4):954-64.
2003: Jensen Anders A; Mikkelsen Ivan; Frølund Bente; Bräuner-Osborne Hans; Falch Erik; Krogsgaard-Larsen Povl
Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors.
Molecular pharmacology 2003;64(4):865-75.
2003: Valgeirsson Jon; Christensen Jeppe K; Kristensen Anders S; Pickering Darryl S; Nielsen Birgitte; Fischer Christina H; Bräuner-Osborne Hans; Nielsen Elsebet Ø; Krogsgaard-Larsen Povl; Madsen Ulf
Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues.
Bioorganic & medicinal chemistry 2003;11(20):4341-9.
2003: Sarup Alan; Larsson Orla Miller; Bolvig Tina; Frølund Bente; Krogsgaard-Larsen Povl; Schousboe Arne
Effects of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazol (exo-THPO) and its N-substituted analogs on GABA transport in cultured neurons and astrocytes and by the four cloned mouse GABA transporters.
Neurochemistry international 2003;43(4-5):445-51.
2003: Krehan Dorte; Frølund Bente; Krogsgaard-Larsen Povl; Kehler Jan; Johnston Graham A R; Chebib Mary
Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists.
Neurochemistry international 2003;42(7):561-5.
2003: Frølund Bente; Tagmose Lena; Jørgensen Anne T; Kristiansen Uffe; Stensbøl Tine B; Liljefors Tommy; Krogsgaard-Larsen Povl
Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABA A antagonists.
European journal of medicinal chemistry 2003;38(4):447-9.
2003: Brehm Lotte; Greenwood Jeremy R; Hansen Kasper B; Nielsen Birgitte; Egebjerg Jan; Stensbøl Tine B; Bräuner-Osborne Hans; Sløk Frank A; Kronborg Tine T A; Krogsgaard-Larsen Povl
(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.
Journal of medicinal chemistry 2003;46(8):1350-8.
2003: Bunch Lennart; Liljefors Tommy; Greenwood Jeremy R; Frydenvang Karla; Bräuner-Osborne Hans; Krogsgaard-Larsen Povl; Madsen Ulf
Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue.
The Journal of organic chemistry 2003;68(4):1489-95.
2003: Johansen Tommy N; Greenwood Jeremy R; Frydenvang Karla; Madsen Ulf; Krogsgaard-Larsen Povl
Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors.
Chirality 2003;15(2):167-79.
2003: Mellor I R; Brier T J; Pluteanu F; Strømgaard K; Saghyan A; Eldursi N; Brierley M J; Andersen K; Jaroszewski J W; Krogsgaard-Larsen P; Usherwood P N R
Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors.
Neuropharmacology 2003;44(1):70-80.
2003: Nielsen Mai Marie; Liljefors Tommy; Krogsgaard-Larsen Povl; Egebjerg Jan
The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741.
Molecular pharmacology 2003;63(1):19-25.
2002: Kromann Hasse; Krikstolaityte Sonata; Andersen Anne J; Andersen Kim; Krogsgaard-Larsen Povl; Jaroszewski Jerzy W; Egebjerg Jan; Strømgaard Kristian
Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors.
Journal of medicinal chemistry 2002;45(26):5745-54.
2002: Mortensen Martin; Frølund Bente; Jørgensen Anne T; Liljefors Tommy; Krogsgaard-Larsen Povl; Ebert Bjarke
Activity of novel 4-PIOL analogues at human alpha 1 beta 2 gamma 2S GABA(A) receptors--correlation with hydrophobicity.
European journal of pharmacology 2002;451(2):125-32.
2002: Clausen Rasmus P; Bräuner-Osborne Hans; Greenwood Jeremy R; Hermit Mette B; Stensbøl Tine B; Nielsen Birgitte; Krogsgaard-Larsen Povl
Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.
Journal of medicinal chemistry 2002;45(19):4240-5.
2002: Frølund Bente; Ebert Bjarke; Kristiansen Uffe; Liljefors Tommy; Krogsgaard-Larsen Povl
GABA(A) receptor ligands and their therapeutic potentials.
Current topics in medicinal chemistry 2002;2(8):817-32.
2002: White H Steve; Sarup Alan; Bolvig Tina; Kristensen Anders S; Petersen Gitte; Nelson Nathan; Pickering Darryl S; Larsson Orla M; Frølund Bente; Krogsgaard-Larsen Povl; Schousboe Arne
Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs.
The Journal of pharmacology and experimental therapeutics 2002;302(2):636-44.
2002: Johansen Tommy N; Janin Yves L; Nielsen Birgitte; Frydenvang Karla; Bräuner-Osborne Hans; Stensbøl Tine B; Vogensen Stine B; Madsen Ulf; Krogsgaard-Larsen Povl
2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors.
Bioorganic & medicinal chemistry 2002;10(7):2259-66.
2002: Frølund Bente; Jørgensen Anne T; Tagmose Lena; Stensbøl Tine B; Vestergaard Henrik T; Engblom Christine; Kristiansen Uffe; Sanchez Connie; Krogsgaard-Larsen Povl; Liljefors Tommy
Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.
Journal of medicinal chemistry 2002;45(12):2454-68.
2002: Guldbrandt Mette; Johansen Tommy N; Frydenvang Karla; Bräuner-Osborne Hans; Stensbøl Tine B; Nielsen Birgitte; Karla Rolf; Santi Flavio; Krogsgaard-Larsen Povl; Madsen Ulf
Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs.
Chirality 2002;14(4):351-63.
2002: Strømgaard Kristian; Mellor Ian R; Andersen Kim; Neagoe Ioana; Pluteanu Florentina; Usherwood Peter N R; Krogsgaard-Larsen Povl; Jaroszewski Jerzy W
Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist.
Bioorganic & medicinal chemistry letters 2002;12(8):1159-62.
2002: Bunch Lennart; Krogsgaard-Larsen Povl; Madsen Ulf
Regioselective lithiation and functionalization of 3-(benzyloxy)isothiazole: application to the synthesis of thioibotenic acid.
The Journal of organic chemistry 2002;67(7):2375-7.
2002: Kromann Hasse; Sløk Frank A; Stensbøl Tine B; Bräuner-Osborne Hans; Madsen Ulf; Krogsgaard-Larsen Povl
Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids.
Journal of medicinal chemistry 2002;45(4):988-91.
2002: Stensbøl Tine B; Uhlmann Peter; Morel Sandrine; Eriksen Birgitte L; Felding Jakob; Kromann Hasse; Hermit Mette B; Greenwood Jeremy R; Braüner-Osborne Hans; Madsen Ulf; Junager Finn; Krogsgaard-Larsen Povl; Begtrup Mikael; Vedsø Per
Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology.
Journal of medicinal chemistry 2002;45(1):19-31.
2002: Krogsgaard-Larsen Povl; Frølund Bente; Liljefors Tommy
Specific GABA(A) agonists and partial agonists.
Chemical record (New York, N.Y.) 2002;2(6):419-30.
2002: Stensbøl Tine Bryan; Madsen Ulf; Krogsgaard-Larsen Povl
The AMPA receptor binding site: focus on agonists and competitive antagonists.
Current pharmaceutical design 2002;8(10):857-72.
2001: Strømgaard K; Andersen K; Krogsgaard-Larsen P; Jaroszewski J W
Recent advances in the medicinal chemistry of polyamine toxins.
Mini reviews in medicinal chemistry 2001;1(4):317-38.
2001: Madsen U; Stensbøl T B; Krogsgaard-Larsen P
Inhibitors of AMPA and kainate receptors.
Current medicinal chemistry 2001;8(11):1291-301.
2001: Ebert B; Mortensen M; Thompson S A; Kehler J; Wafford K A; Krogsgaard-Larsen P
Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABA(A) receptors.
Bioorganic & medicinal chemistry letters 2001;11(12):1573-7.
2001: Bunch L; Johansen T H; Bräuner-Osborne H; Stensbøl T B; Johansen T N; Krogsgaard-Larsen P; Madsen U
Synthesis and receptor binding affinity of new selective GluR5 ligands.
Bioorganic & medicinal chemistry 2001;9(4):875-9.
2001: Jensen A A; Madsen B E; Krogsgaard-Larsen P; Bräuner-Osborne H
Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor.
European journal of pharmacology 2001;417(3):177-80.
2001: Bräuner-Osborne H; Jensen A A; Sheppard P O; Brodin B; Krogsgaard-Larsen P; O'Hara P
Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D.
Biochimica et biophysica acta 2001;1518(3):237-48.
2001: Madsen U; Bräuner-Osborne H; Frydenvang K; Hvene L; Johansen T N; Nielsen B; Sánchez C; Stensbøl T B; Bischoff F; Krogsgaard-Larsen P
Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors.
Journal of medicinal chemistry 2001;44(7):1051-9.
2001: Bunch L; Norrby P O; Frydenvang K; Krogsgaard-Larsen P; Madsen U
Unprecedented migration of N-alkoxycarbonyl groups in protected pyroglutaminol.
Organic letters 2001;3(3):433-5.
2001: Sørensen U S; Falch E; Stensbøl T B; Jaroszewski J W; Madsen U; Krogsgaard-Larsen P
Structural determinants for AMPA agonist activity of aryl or heteroaryl substituted AMPA analogues. Synthesis and pharmacology.
Archiv der Pharmazie 2001;334(2):62-8.
2001: Stensbøl T B; Jensen H S; Nielsen B; Johansen T N; Egebjerg J; Frydenvang K; Krogsgaard-Larsen P
Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist.
European journal of pharmacology 2001;411(3):245-53.
2001: Johansen T N; Stensbøl T B; Nielsen B; Vogensen S B; Frydenvang K; Sløk F A; Bräüner-Osborne H; Madsen U; Krogsgaard-Larsen P
Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.
Chirality 2001;13(9):523-32.
2000: Frølund B; Tagmose L; Liljefors T; Stensbøl T B; Engblom C; Kristiansen U; Krogsgaard-Larsen P
A novel class of potent 3-isoxazolol GABA(A) antagonists: design, synthesis, and pharmacology.
Journal of medicinal chemistry 2000;43(26):4930-3.
2000: Bang-Andersen B; Ahmadian H; Lenz S M; Stensbøl T B; Madsen U; Bøgesø K P; Krogsgaard-Larsen P
Structural determinants of AMPA agonist activity in analogues of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid: synthesis and pharmacology.
Journal of medicinal chemistry 2000;43(25):4910-8.
2000: Strømgaard K; Brier T J; Andersen K; Mellor I R; Saghyan A; Tikhonov D; Usherwood P N; Krogsgaard-Larsen P; Jaroszewski J W
Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues.
Journal of medicinal chemistry 2000;43(23):4526-33.
2000: Vogensen S B; Jensen H S; Stensbøl T B; Frydenvang K; Bang-Andersen B; Johansen T N; Egebjerg J; Krogsgaard-Larsen P
Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist.
Chirality 2000;12(10):705-13.
2000: Bräuner-Osborne H; Hermit M B; Nielsen B; Krogsgaard-Larsen P; Johansen T N
A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2.
European journal of pharmacology 2000;406(1):41-4.
2000: Jensen A A; Spalding T A; Burstein E S; Sheppard P O; O'Hara P J; Brann M R; Krogsgaard-Larsen P; Bräuner-Osborne H
Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor.
The Journal of biological chemistry 2000;275(38):29547-55.
2000: Krogsgaard-Larsen P; Frølund B; Frydenvang K
GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.
Current pharmaceutical design 2000;6(12):1193-209.
2000: Bräuner-Osborne H; Egebjerg J; Nielsen E O; Madsen U; Krogsgaard-Larsen P
Ligands for glutamate receptors: design and therapeutic prospects.
Journal of medicinal chemistry 2000;43(14):2609-45.
2000: Jensen A A; Sheppard P O; O'Hara P J; Krogsgaard-Larsen P; Bräuner-Osborne H
The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity.
European journal of pharmacology 2000;397(2-3):247-53.
2000: Bräuner-Osborne H; Krogsgaard-Larsen P
Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain.
Genomics 2000;65(2):121-8.
2000: Sørensen U S; Falch E; Krogsgaard-Larsen P
A novel route to 5-substituted 3-isoxazolols. Cyclization of N, O-DiBoc beta-keto hydroxamic acids synthesized via acyl Meldrum's acids.
The Journal of organic chemistry 2000;65(4):1003-7.
2000: Strømgaard K; Bjørnsdottir I; Andersen K; Brierley M J; Rizoli S; Eldursi N; Mellor I R; Usherwood P N; Hansen S H; Krogsgaard-Larsen P; Jaroszewski J W
Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12.
Chirality 2000;12(2):93-102.
2000: Stuhr-Hansen N; Ebert B; Krogsgaard-Larsen P; Kehler J
Synthesis and pharmacology of seleninic acid analogues of the inhibitory neurotransmitter gamma-aminobutyric acid.
Organic letters 2000;2(1):7-9.
2000: Madsen U; Sløk F A; Stensbøl T B; Bräuner-Osborne H; Lützhøft H H; Poulsen M V; Eriksen L; Krogsgaard-Larsen P
Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist.
European journal of medicinal chemistry 2000;35(1):69-76.
1999: Falch E; Perregaard J; FrLlund B; SLkilde B; Buur A; Hansen L M; Frydenvang K; Brehm L; Bolvig T; Larsson O M; Sanchez C; White H S; Schousboe A; Krogsgaard-Larsen P
Selective inhibitors of glial GABA uptake: synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues.
Journal of medicinal chemistry 1999;42(26):5402-14.
1999: Stromgaard K; Brierley M J; Andersen K; Sløk F A; Mellor I R; Usherwood P N; Krogsgaard-Larsen P; Jaroszewski J W
Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor.
Journal of medicinal chemistry 1999;42(25):5224-34.
1999: Bräuner-Osborne H; Krogsgaard-Larsen P
Functional pharmacology of cloned heterodimeric GABAB receptors expressed in mammalian cells.
British journal of pharmacology 1999;128(7):1370-4.
1999: Bolvig T; Larsson O M; Pickering D S; Nelson N; Falch E; Krogsgaard-Larsen P; Schousboe A
Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity.
European journal of pharmacology 1999;375(1-3):367-74.
1999: Stensbøl T B; Sløk F A; Trometer J; Hurt S; Ebert B; Kjøller C; Egebjerg J; Madsen U; Diemer N H; Krogsgaard-Larsen P
Characterization of a new AMPA receptor radioligand, [3H]2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid.
European journal of pharmacology 1999;373(2-3):251-62.
1999: Bräuner-Osborne H; Jensen A A; Sheppard P O; O'Hara P; Krogsgaard-Larsen P
The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain.
The Journal of biological chemistry 1999;274(26):18382-6.
1999: Karla R; Ebert B; Thorkildsen C; Herdeis C; Johansen T N; Nielsen B; Krogsgaard-Larsen P
Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4-chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4-chlorophenyl)pentanoic acid.
Journal of medicinal chemistry 1999;42(11):2053-9.
1999: Pedersen H; Bräuner-Osborne H; Ball R G; Frydenvang K; Meier E; Bøgesø K P; Krogsgaard-Larsen P
Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine bioisosteres of arecoline.
Bioorganic & medicinal chemistry 1999;7(5):795-809.
1999: Ebert B; Frølund B; Diemer N H; Krogsgaard-Larsen P
Equilibrium binding characteristics of [3H]thiomuscimol.
Neurochemistry international 1999;34(5):427-34.
1999: Kehler J; Stensbøl T B; Krogsgaard-Larsen P
Piperidinyl-3-phosphinic acids as novel uptake inhibitors of the neurotransmitter gamma-aminobutyric acid (GABA).
Bioorganic & medicinal chemistry letters 1999;9(6):811-4.
1999: Møller E H; Egebjerg J; Brehm L; Stensbøl T B; Johansen T N; Madsen U; Krogsgaard-Larsen P
Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1-4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.
Chirality 1999;11(10):752-9.
1998: Falch E; Brehm L; Mikkelsen I; Johansen T N; Skjaerbaek N; Nielsen B; Stensbøl T B; Ebert B; Krogsgaard-Larsen P
Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships.
Journal of medicinal chemistry 1998;41(14):2513-23.
1998: Bräuner-Osborne H; Nielsen B; Krogsgaard-Larsen P
Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors.
European journal of pharmacology 1998;350(2-3):311-6.
1998: Johansen T N; Ebert B; Bräuner-Osborne H; Didriksen M; Christensen I T; Søby K K; Madsen U; Krogsgaard-Larsen P; Brehm L
Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.
Journal of medicinal chemistry 1998;41(6):930-9.
1998: Skjaerbaek N; Brehm L; Johansen T N; Hansen L M; Nielsen B; Ebert B; Søby K K; Stensbøl T B; Falch E; Krogsgaard-Larsen P
Aryl and cycloalkyl analogues of AMPA: synthetic, pharmacological and stereochemical aspects.
Bioorganic & medicinal chemistry 1998;6(1):119-31.
1998: Bräuner-Osborne H; Krogsgaard-Larsen P
Pharmacology of (S)-homoquisqualic acid and (S)-2-amino-5-phosphonopentanoic acid [(S)-AP5] at cloned metabotropic glutamate receptors.
British journal of pharmacology 1998;123(2):269-74.
1998: Krogsgaard-Larsen P; Frølund B F; Falch E
Inhibitors of gamma-aminobutyric acid transport as experimental tools and therapeutic agents.
Methods in enzymology 1998;296():165-75.
1997: Ahmadian H; Nielsen B; Bräuner-Osborne H; Johansen T N; Stensbøl T B; Sløk F A; Sekiyama N; Nakanishi S; Krogsgaard-Larsen P; Madsen U
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.
Journal of medicinal chemistry 1997;40(22):3700-5.
1997: Bráuner-Osborne H; Nielsen B; Stensbøl T B; Johansen T N; Skjaerbaek N; Krogsgaard-Larsen P
Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors.
European journal of pharmacology 1997;335(2-3):R1-3.
1997: Matzen L; Ebert B; Stensbøl T B; Frølund B; Jaroszewski J W; Krogsgaard-Larsen P
Bioisosterically modified dipeptide excitatory amino acid receptor antagonists containing 3-oxygenated isothiazole ring systems.
Bioorganic & medicinal chemistry 1997;5(8):1569-75.
1997: Bang-Andersen B; Lenz S M; Skjaerbaek N; Søby K K; Hansen H O; Ebert B; Bøgesø K P; Krogsgaard-Larsen P
Heteroaryl analogues of AMPA. Synthesis and quantitative structure-activity relationships.
Journal of medicinal chemistry 1997;40(18):2831-42.
1997: Matzen L; Engesgaard A; Ebert B; Didriksen M; Frølund B; Krogsgaard-Larsen P; Jaroszewski J W
AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid.
Journal of medicinal chemistry 1997;40(4):520-7.
1997: Johansen T N; Frydenvang K; Ebert B; Madsen U; Krogsgaard-Larsen P
Excitatory amino acid receptor antagonists: resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA).
Chirality 1997;9(5-6):529-36.
1997: Johansen T N; Ebert B; Falch E; Krogsgaard-Larsen P
AMPA receptor agonists: resolution, configurational assignment, and pharmacology of (+)-(S)- and (-)-(R)-2-amino-3-[3-hydroxy-5-(2-pyridyl)-isoxazol-4-yl]-propionic acid (2-Py-AMPA).
Chirality 1997;9(3):274-80.
1996: Bräuner-Osborne H; Ebert B; Brann M R; Falch E; Krogsgaard-Larsen P
Functional partial agonism at cloned human muscarinic acetylcholine receptors.
European journal of pharmacology 1996;313(1-2):145-50.
1996: Ebert B; Madsen U; Søby K K; Krogsgaard-Larsen P
Functional partial agonism at ionotropic excitatory amino acid receptors.
Neurochemistry international 1996;29(3):309-16.
1996: Bräuner-Osborne H; Sløk F A; Skjaerbaek N; Ebert B; Sekiyama N; Nakanishi S; Krogsgaard-Larsen P
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.
Journal of medicinal chemistry 1996;39(16):3188-94.
1996: Madsen U; Bang-Andersen B; Brehm L; Christensen I T; Ebert B; Kristoffersen I T; Lang Y; Krogsgaard-Larsen P
Synthesis and pharmacology of highly selective carboxy and phosphono isoxazole amino acid AMPA receptor antagonists.
Journal of medicinal chemistry 1996;39(8):1682-91.
1996: Søkilde B; Mikkelsen I; Stensbøl T B; Andersen B; Ebdrup S; Krogsgaard-Larsen P; Falch E
Analogues of carbacholine: synthesis and relationship between structure and affinity for muscarinic and nicotinic acetylcholine receptors.
Archiv der Pharmazie 1996;329(2):95-104.
1996: Madsen U; Frydenvang K; Ebert B; Johansen T N; Brehm L; Krogsgaard-Larsen P
N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
Journal of medicinal chemistry 1996;39(1):183-90.
1996: Jaroszewski J W; Matzen L; Frølund B; Krogsgaard-Larsen P
Neuroactive polyamine wasp toxins: nuclear magnetic resonance spectroscopic analysis of the protolytic properties of philanthotoxin-343.
Journal of medicinal chemistry 1996;39(2):515-21.
1995: Frølund B; Kristiansen U; Brehm L; Hansen A B; Krogsgaard-Larsen P; Falch E
Partial GABAA receptor agonists. Synthesis and in vitro pharmacology of a series of nonannulated analogs of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol.
Journal of medicinal chemistry 1995;38(17):3287-96.
1995: Bräuner-Osborne H; Ebert B; Brann M R; Falch E; Krogsgaard-Larsen P
Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors.
Journal of medicinal chemistry 1995;38(12):2188-95.
1995: Bischoff F; Johansen T N; Ebert B; Krogsgaard-Larsen P; Madsen U
Excitatory amino acid receptor ligands: asymmetric synthesis, absolute stereochemistry and pharmacology of (R)- and (S)-homoibotenic acid.
Bioorganic & medicinal chemistry 1995;3(5):553-8.
1995: Ebert B; Andersen S; Krogsgaard-Larsen P
Ketobemidone, methadone and pethidine are non-competitive N-methyl-D-aspartate (NMDA) antagonists in the rat cortex and spinal cord.
Neuroscience letters 1995;187(3):165-8.
1995: Frølund B; Jeppesen L; Krogsgaard-Larsen P; Hansen J J
GABAA agonists: resolution and pharmacology of (+)- and (-)-isoguvacine oxide.
Chirality 1995;7(6):434-8.
1994: Ebert B; Wafford K A; Whiting P J; Krogsgaard-Larsen P; Kemp J A
Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.
Molecular pharmacology 1994;46(5):957-63.
1994: Johansen T N; Frydenvang K; Ebert B; Krogsgaard-Larsen P; Madsen U
Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands.
Journal of medicinal chemistry 1994;37(20):3252-62.
1994: Krogsgaard-Larsen P; Frølund B; Jørgensen F S; Schousboe A
GABAA receptor agonists, partial agonists, and antagonists. Design and therapeutic prospects.
Journal of medicinal chemistry 1994;37(16):2489-505.
1994: Ebert B; Madsen U; Lund T M; Lenz S M; Krogsgaard-Larsen P
Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA.
Neurochemistry international 1994;24(6):507-15.
1994: Ebert B; Lenz S; Brehm L; Bregnedal P; Hansen J J; Frederiksen K; Bøgesø K P; Krogsgaard-Larsen P
Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA].
Journal of medicinal chemistry 1994;37(7):878-84.
1994: Frydenvang K; Hansen J J; Krogsgaard-Larsen P; Mitrovic A; Tran H; Drew C A; Johnston G A
GABAB antagonists: resolution, absolute stereochemistry, and pharmacology of (R)- and (S)-phaclofen.
Chirality 1994;6(7):583-9.
1993: Krogsgaard-Larsen P; Wahl P; Schousboe A; Madsen U; Hansen J J
Excitatory amino acid research in Alzheimer's disease: enhancement and blockade of receptor functions.
Biochemical Society transactions 1993;21(1):102-6.
1993: Madsen U; Ebert B; Hansen J J; Krogsgaard-Larsen P
The non-depolarizing D-form of bromohomoibotenic acid enhances depolarizations evoked by the L-form or quisqualate.
European journal of pharmacology 1993;230(3):383-6.
1993: Lagersted A; Falch E; Ebert B; Krogsgaard-Larsen P
Conformational aspects of the muscarinic receptor interactions of bicyclic isoxazole ester bioisosteres of arecoline.
Drug design and discovery 1993;9(3-4):237-50.
1993: Buur J R; Hjeds H; Krogsgaard-Larsen P; Jørgensen F S
Conformational analysis and molecular modelling of a partial GABAA agonist and a glycine antagonist related to the GABAA agonist, THIP.
Drug design and discovery 1993;10(3):213-29.
1992: Krogsgaard-Larsen P; Hansen J J
Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design.
Toxicology letters 1992;64-65 Spec No():409-16.
1992: Wahl P; Nielsen B; Krogsgaard-Larsen P; Hansen J J; Schousboe A; Miledi R
Stereoselective effects of AMOA on non-NMDA receptors expressed in Xenopus oocytes.
Journal of neuroscience research 1992;33(3):392-7.
1992: Christensen I T; Ebert B; Madsen U; Nielsen B; Brehm L; Krogsgaard-Larsen P
Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid.
Journal of medicinal chemistry 1992;35(19):3512-9.
1992: Kristiansen U; Hedegaard A; Herdeis C; Lund T M; Nielsen B; Hansen J J; Falch E; Hjeds H; Krogsgaard-Larsen P
Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships.
Journal of neurochemistry 1992;58(3):1150-9.
1992: Krogsgaard-Larsen P
GABA and glutamate receptors as therapeutic targets in neurodegenerative disorders.
Pharmacology & toxicology 1992;70(2):95-104.
1991: Ebert B; Wong E H; Krogsgaard-Larsen P
Identification of a novel NMDA receptor in rat cerebellum.
European journal of pharmacology 1991;208(1):49-52.
1991: Kristiansen U; Lambert J D; Falch E; Krogsgaard-Larsen P
Electrophysiological studies of the GABAA receptor ligand, 4-PIOL, on cultured hippocampal neurones.
British journal of pharmacology 1991;104(1):85-90.
1991: Krogsgaard-Larsen P; Ferkany J W; Nielsen E O; Madsen U; Ebert B; Johansen J S; Diemer N H; Bruhn T; Beattie D T; Curtis D R
Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection.
Journal of medicinal chemistry 1991;34(1):123-30.
1991: Ebert B; Madsen U; Johansen T N; Krogsgaard-Larsen P
NMDA receptor agonists: relationships between structure and biological activity.
Advances in experimental medicine and biology 1991;287():483-7.
1990: Madsen U; Ferkany J W; Jones B E; Ebert B; Johansen T N; Holm T; Krogsgaard-Larsen P
NMDA receptor agonists derived from ibotenic acid. Preparation, neuroexcitation and neurotoxicity.
European journal of pharmacology 1990;189(6):381-91.
1990: Frandsen A; Krogsgaard-Larsen P; Schousboe A
Novel glutamate receptor antagonists selectively protect against kainic acid neurotoxicity in cultured cerebral cortex neurons.
Journal of neurochemistry 1990;55(5):1821-3.
1990: Madsen U; Nielsen E O; Curtis D R; Beattie D T; Krogsgaard-Larsen P
Synthesis and single cell pharmacology of potential heterocyclic bioisosteres of the excitatory amino acid antagonist glutamic acid diethyl ester.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) 1990;44(1):96-102.
1990: Hansen J J; Krogsgaard-Larsen P
Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors.
Medicinal research reviews 1990;10(1):55-94.
1990: Nielsen L; Brehm L; Krogsgaard-Larsen P
GABA agonists and uptake inhibitors. Synthesis, absolute stereochemistry, and enantioselectivity of (R)-(-)- and (S)-(+)-homo-beta-proline.
Journal of medicinal chemistry 1990;33(1):71-7.
1990: Madsen U; Brehm L; Schaumburg K; Jørgensen F S; Krogsgaard-Larsen P
Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors.
Journal of medicinal chemistry 1990;33(1):374-80.
1990: Hansen J J; Nielsen B; Reinhardt A; Krogsgaard-Larsen P
Excitatory amino acid receptor agonists. Enantiomeric resolutions by use of enzymes and chiral HPLC.
Acta pharmaceutica Nordica 1990;2(3):185-92.
1989: Hansen J J; Nielsen B; Krogsgaard-Larsen P; Brehm L; Nielsen E O; Curtis D R
Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid.
Journal of medicinal chemistry 1989;32(10):2254-60.
1989: Falch E; Krogsgaard-Larsen P
GABA uptake inhibitors containing mono- and diarylmethoxyalkyl N-substituents.
Drug design and delivery 1989;4(3):205-15.
1989: Nielsen E O; Aarslew-Jensen M; Diemer N H; Krogsgaard-Larsen P; Schousboe A
Baclofen-induced, calcium-dependent stimulation of in vivo release of D-[3H]aspartate from rat hippocampus monitored by intracerebral microdialysis.
Neurochemical research 1989;14(4):321-6.
1988: Sauerberg P; Falch E; Meier E; Lembøl H L; Krogsgaard-Larsen P
Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres.
Journal of medicinal chemistry 1988;31(7):1312-6.
1988: Krogsgaard-Larsen P; Falch E; Sauerberg P; Freedman S B; Lembøl H L; Meier E
Bioisosteres of arecoline as novel CNS-active muscarinic agonists.
Trends in pharmacological sciences 1988;Suppl():69-74.
1988: Krogsgaard-Larsen P
GABA synaptic mechanisms: stereochemical and conformational requirements.
Medicinal research reviews 1988;8(1):27-56.
1987: Falch E; Meldrum B S; Krogsgaard-Larsen P
GABA uptake inhibitors. Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid.
Drug design and delivery 1987;2(1):9-21.
1987: Byberg J R; Labouta I M; Falch E; Hjeds H; Krogsgaard-Larsen P; Curtis D R; Gynther B D
Synthesis and biological activity of a GABAA agonist which has no effect on benzodiazepine binding and of structurally related glycine antagonists.
Drug design and delivery 1987;1(4):261-74.
1987: Krogsgaard-Larsen P; Falch E; Larsson O M; Schousboe A
GABA uptake inhibitors: relevance to antiepileptic drug research.
Epilepsy research 1987;1(2):77-93.
1986: Sauerberg P; Fjalland B; Larsen J J; Bach-Lauritsen T; Falch E; Krogsgaard-Larsen P
Pharmacological profile of a novel class of muscarinic acetylcholine receptor agonists.
European journal of pharmacology 1986;130(1-2):125-31.
1986: Falch E; Hedegaard A; Nielsen L; Jensen B R; Hjeds H; Krogsgaard-Larsen P
Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.
Journal of neurochemistry 1986;47(3):898-903.
1986: Sauerberg P; Larsen J J; Falch E; Krogsgaard-Larsen P
A novel class of conformationally restricted heterocyclic muscarinic agonists.
Journal of medicinal chemistry 1986;29(6):1004-9.
1986: Madsen U; Schaumburg K; Brehm L; Curtis D R; Krogsgaard-Larsen P
Ibotenic acid analogues. Synthesis and biological testing of two bicyclic 3-isoxazolol amino acids.
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 1986;40(2):92-7.
1986: Brehm L; Krogsgaard-Larsen P; Schaumburg K; Johansen J S; Falch E; Curtis D R
Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions.
Journal of medicinal chemistry 1986;29(2):224-9.
1985: Krogsgaard-Larsen P; Brehm L; Johansen J S; Vinzents P; Lauridsen J; Curtis D R
Synthesis and structure-activity studies on excitatory amino acids structurally related to ibotenic acid.
Journal of medicinal chemistry 1985;28(5):673-9.
1985: Lauridsen J; Honoré T; Krogsgaard-Larsen P
Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors.
Journal of medicinal chemistry 1985;28(5):668-72.
1985: Falch E; Jacobsen P; Krogsgaard-Larsen P; Curtis D R
GABA-mimetic activity and effects on diazepam binding of aminosulphonic acids structurally related to piperidine-4-sulphonic acid.
Journal of neurochemistry 1985;44(1):68-75.
1985: Krogsgaard-Larsen P; Falch E; Hjeds H
Heterocyclic analogues of GABA: chemistry, molecular pharmacology and therapeutic aspects.
Progress in medicinal chemistry 1985;22():67-120.
1984: Krogsgaard-Larsen P; Nielsen E O; Curtis D R
Ibotenic acid analogues. Synthesis and biological and in vitro activity of conformationally restricted agonists at central excitatory amino acid receptors.
Journal of medicinal chemistry 1984;27(5):585-91.
1983: Krogsgaard-Larsen P; Mikkelsen H; Jacobsen P; Falch E; Curtis D R; Peet M J; Leah J D
4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
Journal of medicinal chemistry 1983;26(6):895-900.
1983: Hansen J J; Lauridsen J; Nielsen E; Krogsgaard-Larsen P
Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid.
Journal of medicinal chemistry 1983;26(6):901-3.
1983: Krogsgaard-Larsen P; Falch E; Peet M J; Leah J D; Curtis D R
Molecular pharmacology of the GABA receptors and GABA agonists.
Advances in biochemical psychopharmacology 1983;37():1-13.
1982: Krogsgaard-Larsen P; Hjeds H; Curtis D R; Leah J D; Peet M J
Glycine antagonists structurally related to muscimol, THIP, or isoguvacine.
Journal of neurochemistry 1982;39(5):1319-24.
1982: Jacobsen P; Labouta I M; Schaumburg K; Falch E; Krogsgaard-Larsen P
Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors.
Journal of medicinal chemistry 1982;25(10):1157-62.
1982: Krogsgaard-Larsen P; Hansen J J; Lauridsen J; Peet M J; Leah J D; Curtis D R
Glutamic acid agonists. Stereochemical and conformational studies of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and related compounds.
Neuroscience letters 1982;31(3):313-7.
1982: Honoré T; Lauridsen J; Krogsgaard-Larsen P
The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes.
Journal of neurochemistry 1982;38(1):173-8.
1981: Honoré T; Krogsgaard-Larsen P; Hansen J J; Lauridsen J
Glutamate and aspartate agonists structurally related to ibotenic acid.
Molecular and cellular biochemistry 1981;38 Spec No(Pt 1):123-8.
1981: Honoré T; Lauridsen J; Krogsgaard-Larsen P
Ibotenic acid analogues as inhibitors of [3H]glutamic acid binding to cerebellar membranes.
Journal of neurochemistry 1981;36(3):1302-4.
1981: Krogsgaard-Larsen P; Honoré T; Hansen J J; Curtis D R; Lodge D
Structure-activity studies on ibotenic acid and related muscimol analogues.
Advances in biochemical psychopharmacology 1981;27():285-94.
1981: Krogsgaard-Larsen P; Brehm L; Schaumburg K
Muscimol, a psychoactive constituent of Amanita muscaria, as a medicinal chemical model structure.
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 1981;35(5):311-24.
1980: Krogsgaard-Larsen P; Honoré T; Hansen J J; Curtis D R; Lodge D
New class of glutamate agonist structurally related to ibotenic acid.
Nature 1980;284(5751):64-6.

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