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Knut Krohn

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Sanja Pavlica; Frank Peinemann; Antonella Piscioneri; Stephanie Schmitmeier; Michaela Siegmund-Schulz; Loredana De Bartolo; Pietro Favia; Pia Gloeckner; Knut Krohn; Stefania Laera; Augustinus Bader
Effect of native and NH3 plasma-functionalized polymeric membranes on the gene expression profiles of primary hepatocytes.
Axel Weber; Udo zur Stadt; Jutta Bradtke; Martin Horstmann; Knut Krohn; Sabine Leiblein; Sylvia Taube; Andrea Teigler-Schlegel; Holger Christiansen
Quantification of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) using amplicon-fusion-site polymerase chain reaction (AFS-PCR).
Sebastian Weis; Heiko Witt; Henning Wittenburg; Claudia Ruffert; Dorit Schleinitz; Robert Schober; Hans-Ulrich Schulz; Michael Stumvoll; Matthias Blüher; Peter Bugert; Joost P H Drenth; Robert Grützmann; Max Herms; Moritz Jesinghaus; Volker Keim; Peter Kovacs; Knut Krohn; Joachim Mössner; Jonas Rosendahl
Genetic analyses of heme oxygenase 1 (HMOX1) in different forms of pancreatitis.

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All Publications

2012: Sanja Pavlica; Frank Peinemann; Antonella Piscioneri; Stephanie Schmitmeier; Michaela Siegmund-Schulz; Loredana De Bartolo; Pietro Favia; Pia Gloeckner; Knut Krohn; Stefania Laera; Augustinus Bader
Effect of native and NH3 plasma-functionalized polymeric membranes on the gene expression profiles of primary hepatocytes.
Journal of tissue engineering and regenerative medicine 2012;6(6):486-96.
2012: Axel Weber; Udo zur Stadt; Jutta Bradtke; Martin Horstmann; Knut Krohn; Sabine Leiblein; Sylvia Taube; Andrea Teigler-Schlegel; Holger Christiansen
Quantification of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) using amplicon-fusion-site polymerase chain reaction (AFS-PCR).
Experimental hematology & oncology 2012;1(1):33.
2012: Sebastian Weis; Heiko Witt; Henning Wittenburg; Claudia Ruffert; Dorit Schleinitz; Robert Schober; Hans-Ulrich Schulz; Michael Stumvoll; Matthias Blüher; Peter Bugert; Joost P H Drenth; Robert Grützmann; Max Herms; Moritz Jesinghaus; Volker Keim; Peter Kovacs; Knut Krohn; Joachim Mössner; Jonas Rosendahl
Genetic analyses of heme oxygenase 1 (HMOX1) in different forms of pancreatitis.
PloS one 2012;7(5):e37981.
2011: Kathrin Müller; Roy E Weiss; Kurt Werner Schmid; Marie-Christine Many; Jens Mittag; Matthias Blüher; Dagmar Führer; Nora Klöting; Knut Krohn
TSH compensates thyroid-specific IGF-I receptor knockout and causes papillary thyroid hyperplasia.
Molecular endocrinology (Baltimore, Md.) 2011;25(11):1867-79.
2011: Kathrin Müller; Knut Krohn; Markus Eszlinger; Marian Ludgate; Dagmar Führer
Effect of iodine on early stage thyroid autonomy.
Genomics 2011;97(2):94-100.
2010: Stephan Lorenz; Markus Eszlinger; Ralf Paschke; Gabriela Aust; Michael Weick; Dagmar Führer; Knut Krohn
Calcium signaling of thyrocytes is modulated by TSH through calcium binding protein expression.
Biochimica et biophysica acta 2010;1803(3):352-60.
2010: Hans Binder; Knut Krohn; Conrad J Burden
Washing scaling of GeneChip microarray expression.
BMC bioinformatics 2010;11():291.
2010: Anke Tönjes; Eleftheria Zeggini; Peter Kovacs; Yvonne Böttcher; Dorit Schleinitz; Kerstin Dietrich; Andrew P Morris; Beate Enigk; Nigel W Rayner; Moritz Koriath; Markus Eszlinger; Anu Kemppinen; Inga Prokopenko; Katrin Hoffmann; Daniel Teupser; Joachim Thiery; Knut Krohn; Mark I McCarthy; Michael Stumvoll
Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany.
European journal of human genetics : EJHG 2010;18(1):104-10.
2009: Anke Tönjes; Moritz Koriath; Dorit Schleinitz; Kerstin Dietrich; Yvonne Böttcher; Nigel W Rayner; Peter Almgren; Beate Enigk; Olaf Richter; Silvio Rohm; Antje Fischer-Rosinsky; Andreas Pfeiffer; Katrin Hoffmann; Knut Krohn; Gabriela Aust; Joachim Spranger; Leif Groop; Matthias Blüher; Peter Kovacs; Michael Stumvoll
Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.
Human molecular genetics 2009;18(23):4662-8.
2009: Sandra Mueller; Hulya Iliksu Gozu; Rifat Bircan; Holger Jaeschke; Markus Eszlinger; Julia Lueblinghoff; Knut Krohn; Ralf Paschke
Cases of borderline in vitro constitutive thyrotropin receptor activity: how to decide whether a thyrotropin receptor mutation is constitutively active or not?
Thyroid : official journal of the American Thyroid Association 2009;19(7):765-73.
2008: Markus Eszlinger; Knut Krohn; Steffen Hauptmann; Henning Dralle; Thomas J Giordano; Ralf Paschke
Perspectives for improved and more accurate classification of thyroid epithelial tumors.
The Journal of clinical endocrinology and metabolism 2008;93(9):3286-94.
2008: Hulya Gozu; Sandra Mueller; Rifat Bircan; Knut Krohn; Gazenfer Ekinci; Dilek Yavuzer; Haluk Sargin; Mehmet Sargin; Tunc Ones; Cem Gezen; Ekrem Orbay; Beyazit Cirakoglu; Ralf Paschke
A new silent germline mutation of the TSH receptor: coexpression in a hyperthyroid family member with a second activating somatic mutation.
Thyroid : official journal of the American Thyroid Association 2008;18(5):499-508.
2008: Hans Binder; Knut Krohn; Stephan Preibisch
"Hook"-calibration of GeneChip-microarrays: chip characteristics and expression measures.
Algorithms for molecular biology : AMB 2008;3():11.
2007: Knut Krohn; Jacqueline Maier; Ralf Paschke
Mechanisms of disease: hydrogen peroxide, DNA damage and mutagenesis in the development of thyroid tumors.
Nature clinical practice. Endocrinology & metabolism 2007;3(10):713-20.
2007: Krzysztof Fujarewicz; Michal Jarzab; Markus Eszlinger; Knut Krohn; Ralf Paschke; Malgorzata Oczko-Wojciechowska; Malgorzata Wiench; Aleksandra Kukulska; Barbara Jarzab; Andrzej Swierniak
A multi-gene approach to differentiate papillary thyroid carcinoma from benign lesions: gene selection using support vector machines with bootstrapping.
Endocrine-related cancer 2007;14(3):809-26.
2007: J Maier; H van Steeg; Conny Th M van Oostrom; Ralf Paschke; R E Weiss; Knut Krohn
Iodine deficiency activates antioxidant genes and causes DNA damage in the thyroid gland of rats and mice.
Biochimica et biophysica acta 2007;1773(6):990-9.
2007: Markus Eszlinger; Knut Krohn; Aleksandra Kukulska; Barbara Jarzab; Ralf Paschke
Perspectives and limitations of microarray-based gene expression profiling of thyroid tumors.
Endocrine reviews 2007;28(3):322-38.
2006: Hulya Gozu; Rifat Bircan; Knut Krohn; Sandra Müller; Selahattin Vural; Cem Gezen; Haluk Sargin; Dilek Yavuzer; Mehmet Sargin; Beyazit Cirakoglu; Ralf Paschke
Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(4):535-45.
2006: J Maier; H van Steeg; Conny Th M van Oostrom; Stefan Karger; Ralf Paschke; Knut Krohn
Deoxyribonucleic acid damage and spontaneous mutagenesis in the thyroid gland of rats and mice.
Endocrinology 2006;147(7):3391-7.
2006: Markus Eszlinger; Malgorzata Wiench; Barbara Jarzab; Knut Krohn; Martin Beck; Jürgen Läuter; Elzbieta Gubała; Krzysztof Fujarewicz; Andrzej Swierniak; Ralf Paschke
Meta- and reanalysis of gene expression profiles of hot and cold thyroid nodules and papillary thyroid carcinoma for gene groups.
The Journal of clinical endocrinology and metabolism 2006;91(5):1934-42.
2006: Markus Eszlinger; Knut Krohn; Martin Beck; David Kipling; Sarah Forbes-Robertson; Jürgen Läuter; Anke Tönjes; David Wynford-Thomas; Ralf Paschke
Comparison of differential gene expression of hot and cold thyroid nodules with primary epithelial cell culture models by investigation of co-regulated gene sets.
Biochimica et biophysica acta 2006;1763(3):263-71.
2006: Gabriela Aust; Knut Krohn; Nils G. Morgenthaler; S Schröder; Alexander Schütz; Jeanett Edelmann; Elke Brylla
Graves' disease and Hashimoto's thyroiditis in monozygotic twins: case study as well as transcriptomic and immunohistological analysis of thyroid tissues.
European journal of endocrinology / European Federation of Endocrine Societies 2006;154(1):13-20.
2005: Romy Frenzel; Knut Krohn; Markus Eszlinger; Anke Tönjes; Ralf Paschke
Sialylation of human thyrotropin receptor improves and prolongs its cell-surface expression.
Molecular pharmacology 2005;68(4):1106-13.
2005: Knut Krohn; Markus Eszlinger; Ralf Paschke; Ingo Roeder; E Schuster
Increased power of microarray analysis by use of an algorithm based on a multivariate procedure.
Bioinformatics (Oxford, England) 2005;21(17):3530-4.
2005: Knut Krohn; Dagmar Führer; Yvonne Bayer; Markus Eszlinger; V F H Brauer; Susanne Neumann; Ralf Paschke
Molecular pathogenesis of euthyroid and toxic multinodular goiter.
Endocrine reviews 2005;26(4):504-24.
2005: Matthias Blüher; Mathias Fasshauer; Susan Kralisch; Michael R Schön; Knut Krohn; Ralf Paschke
Regulation of adiponectin receptor R1 and R2 gene expression in adipocytes of C57BL/6 mice.
Biochemical and biophysical research communications 2005;329(3):1127-32.
2005: Lucy C Crossman; Motomi Mori; Yi-Ching Hsieh; Thoralf Lange; Peter Paschka; Christina A Harrington; Knut Krohn; Dietger Niederwieser; Rüdiger Hehlmann; Andreas Hochhaus; Brian J Druker; Michael W N Deininger
In chronic myeloid leukemia white cells from cytogenetic responders and non-responders to imatinib have very similar gene expression signatures.
Haematologica 2005;90(4):459-64.
2005: Javorina Milosevic; Sigrid C Schwarz; Knut Krohn; Monika Poppe; Alexander Storch; Johannes Schwarz
Low atmospheric oxygen avoids maturation, senescence and cell death of murine mesencephalic neural precursors.
Journal of neurochemistry 2005;92(4):718-29.
2005: M Christoforidis; Ralf Schober; Knut Krohn
Genetic-morphologic association study: association between the low density lipoprotein-receptor related protein (LRP) and cerebral amyloid angiopathy.
Neuropathology and applied neurobiology 2005;31(1):11-9.
2005: Markus Eszlinger; Knut Krohn; Kerstin Berger; Jürgen Läuter; Siegfried Kropf; Martin Beck; Dagmar Führer; Ralf Paschke
Gene expression analysis reveals evidence for increased expression of cell cycle-associated genes and Gq-protein-protein kinase C signaling in cold thyroid nodules.
The Journal of clinical endocrinology and metabolism 2005;90(2):1163-70.
2004: Knut Krohn; Ralf Paschke
BRAF mutations are not an alternative explanation for the molecular etiology of ras-mutation negative cold thyroid nodules.
Thyroid : official journal of the American Thyroid Association 2004;14(5):359-61.
2004: Markus Eszlinger; Knut Krohn; Romy Frenzel; Siegfried Kropf; Anke Tönjes; Ralf Paschke
Gene expression analysis reveals evidence for inactivation of the TGF-beta signaling cascade in autonomously functioning thyroid nodules.
Oncogene 2004;23(3):795-804.
2003: Susanne U Miedlich; Knut Krohn; Ralf Paschke
Update on genetic and clinical aspects of primary hyperparathyroidism.
Clinical endocrinology 2003;59(5):539-54.
2003: Knut Krohn; Ingo Stricker; Peter Emmrich; Ralf Paschke
Cold thyroid nodules show a marked increase in proliferation markers.
Thyroid : official journal of the American Thyroid Association 2003;13(6):569-75.
2003: Thomas Bumm; Christel Müller; Haifa-Kathrin Al-Ali; Knut Krohn; Patricia Shepherd; Erika Schmidt; Sabine Leiblein; Christina Franke; Evelin Hennig; Thomas Friedrich; Rainer Krahl; Dietger Niederwieser; Michael W N Deininger
Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority.
Blood 2003;101(5):1941-9.
2002: Knut Krohn; Ralf Paschke
Somatic mutations in thyroid nodular disease.
Molecular genetics and metabolism 2002;75(3):202-8.
2001: Markus Eszlinger; Knut Krohn; Ralf Paschke
Complementary DNA expression array analysis suggests a lower expression of signal transduction proteins and receptors in cold and hot thyroid nodules.
The Journal of clinical endocrinology and metabolism 2001;86(10):4834-42.
2001: Knut Krohn; Andreas Reske; Frank Ackermann; A Müller; Ralf Paschke
Ras mutations are rare in solitary cold and toxic thyroid nodules.
Clinical endocrinology 2001;55(2):241-8.
2001: Knut Krohn; Ralf Paschke
Loss of heterozygocity at the thyroid peroxidase gene locus in solitary cold thyroid nodules.
Thyroid : official journal of the American Thyroid Association 2001;11(8):741-7.
2001: Henri Wallaschofski; C Orda; Dagmar Führer; Hans-Peter Holzapfel; Knut Krohn; Konstanze Miehle; Susanne Neumann; P Georgi; Ralf Paschke
Distinction between autoimmune and nonautoimmune hyperthyroidism by determination of thyrotropin-receptor antibodies in patients with the scintigraphic diagnosis of disseminated autonomy.
Thyroid : official journal of the American Thyroid Association 2001;11(7):710-1.
2001: Knut Krohn; Ralf Paschke
Clinical review 133: Progress in understanding the etiology of thyroid autonomy.
The Journal of clinical endocrinology and metabolism 2001;86(7):3336-45.
2001: Susanne Neumann; Knut Krohn; S Chey; Ralf Paschke
Mutations in the mouse TSH receptor equivalent to human constitutively activating TSH receptor mutations also cause constitutive activity.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2001;33(5):263-9.
2001: Markus Eszlinger; Knut Krohn; Jürgen Kratzsch; Carsten Voigt; Ralf Paschke
Growth factor expression in cold and hot thyroid nodules.
Thyroid : official journal of the American Thyroid Association 2001;11(2):125-35.
2001: B Trülzsch; Knut Krohn; Peter Wonerow; S Chey; Hans-Peter Holzapfel; Frank Ackermann; Dagmar Führer; Ralf Paschke
Detection of thyroid-stimulating hormone receptor and Gsalpha mutations: in 75 toxic thyroid nodules by denaturing gradient gel electrophoresis.
Journal of molecular medicine (Berlin, Germany) 2001;78(12):684-91.
2000: Knut Krohn; S Wohlgemuth; H Gerber; Ralf Paschke
Hot microscopic areas of iodine-deficient euthyroid goitres contain constitutively activating TSH receptor mutations.
The Journal of pathology 2000;192(1):37-42.
2000: Susanne U Miedlich; Knut Krohn; Peter Lamesch; A Müller; Ralf Paschke
Frequency of somatic MEN1 gene mutations in monoclonal parathyroid tumours of patients with primary hyperparathyroidism.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(1):47-54.
1999: Matthias Blüher; Knut Krohn; Henri Wallaschofski; L E Braverman; Ralf Paschke
Fas and Fas ligand gene expression in autoimmune thyroiditis in BB/W rats.
European journal of endocrinology / European Federation of Endocrine Societies 1999;141(5):506-11.
1999: Matthias Blüher; Knut Krohn; Henri Wallaschofski; L E Braverman; Ralf Paschke
Cytokine gene expression in autoimmune thyroiditis in BioBreeding/Worcester rats.
Thyroid : official journal of the American Thyroid Association 1999;9(10):1049-55.
1999: B Trülzsch; Knut Krohn; Peter Wonerow; Ralf Paschke
DGGE is more sensitive for the detection of somatic point mutations than direct sequencing.
BioTechniques 1999;27(2):266-8.
1999: N Wolf; Knut Krohn; S Bieger; Morten Frödin; Steen Gammeltoft; Kerstin Krieglstein; Klaus Unsicker
Transforming growth factor-beta, but not ciliary neurotrophic factor, inhibits DNA synthesis of adrenal medullary cells in vitro.
Neuroscience 1999;90(2):629-41.
1999: Knut Krohn; Irina Rozovsky; PA Wals; Bruce Teter; Christopher P Anderson; Caleb E Finch
Glial fibrillary acidic protein transcription responses to transforming growth factor-beta1 and interleukin-1beta are mediated by a nuclear factor-1-like site in the near-upstream promoter.
Journal of neurochemistry 1999;72(4):1353-61.
1999: Knut Krohn; Peter Emmrich; N Ott; Ralf Paschke
Increased thyroid epithelial cell proliferation in toxic thyroid nodules.
Thyroid : official journal of the American Thyroid Association 1999;9(3):241-6.
1999: Knut Krohn
TGF-beta1-dependent differential expression of a rat homolog for latent TGF-beta binding protein in astrocytes and C6 glioma cells.
Glia 1999;25(4):332-42.
1999: Max Holzer; Hans-Peter Holzapfel; Knut Krohn; Thomas Arendt
Alterations in content and phosphorylation state of cytoskeletal proteins in the sciatic nerve during ageing and in Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 1999;106(7-8):743-55.
1999: Frank Ackermann; Knut Krohn; M Windgassen; Michael Buchfelder; Rudolf Fahlbusch; Ralf Paschke
Acromegaly in a family without a mutation in the menin gene.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1999;107(1):93-6.
1998: Kerstin Krieglstein; P Henheik; Lilla M Farkas; J Jaszai; D Galter; Knut Krohn; Klaus Unsicker
Glial cell line-derived neurotrophic factor requires transforming growth factor-beta for exerting its full neurotrophic potential on peripheral and CNS neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(23):9822-34.
1998: Dagmar Führer; C Kubisch; U Scheibler; Peter Lamesch; Knut Krohn; Ralf Paschke
The extracellular thyrotropin receptor domain is not a major candidate for mutations in toxic thyroid nodules.
Thyroid : official journal of the American Thyroid Association 1998;8(11):997-1001.
1998: Knut Krohn; Dagmar Führer; Hans-Peter Holzapfel; Ralf Paschke
Clonal origin of toxic thyroid nodules with constitutively activating thyrotropin receptor mutations.
The Journal of clinical endocrinology and metabolism 1998;83(1):130-4.
1997: S F Arab; Knut Krohn; A Lachmund; Klaus Unsicker; Clemens Suter-Crazzolara
The gene encoding bovine brain-derived neurotrophic factor (BDNF).
Gene 1997;185(1):95-8.