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Tobias Krojer

Research Profile

Chemicals & Drugs

Procedures

X Ray Crystallography

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Publications

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Peter Canning; Apirat Chaikuad; Christopher D O Cooper; Opher Gileadi; Viktorija Hojzan; Tracy Keates; Stefan Knapp; Tobias Krojer; Brian D Marsden; James Murray; Ashley C W Pike; Chancievan Thangaratnarajah; Frank von Delft; Alex N Bullock
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
D Sean Froese; Roy A Gravel; Wasim Kiyani; Tobias Krojer; Udo Oppermann; Roshi Shrestha; Frank von Delft; Xuchu Wu; Wyatt W Yue
Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.
Justyna Sawa; Flavia Canellas; Michael Ehrmann; Tobias Krojer; Hélène Malet; Tim Clausen
Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope.

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All Publications

2013: Peter Canning; Apirat Chaikuad; Christopher D O Cooper; Opher Gileadi; Viktorija Hojzan; Tracy Keates; Stefan Knapp; Tobias Krojer; Brian D Marsden; James Murray; Ashley C W Pike; Chancievan Thangaratnarajah; Frank von Delft; Alex N Bullock
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
The Journal of biological chemistry 2013;288(11):7803-14.
2012: D Sean Froese; Roy A Gravel; Wasim Kiyani; Tobias Krojer; Udo Oppermann; Roshi Shrestha; Frank von Delft; Xuchu Wu; Wyatt W Yue
Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.
Biochemistry 2012;51(25):5083-90.
2011: Justyna Sawa; Flavia Canellas; Michael Ehrmann; Tobias Krojer; Hélène Malet; Tim Clausen
Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope.
The Journal of biological chemistry 2011;286(35):30680-90.
2011: Grazyna Kochan; Tobias Krojer; David Harvey; Roman Fischer; Liye Chen; Melanie Vollmar; Frank von Delft; Kathryn L Kavanagh; Matthew A Brown; Paul Bowness; Paul Wordsworth; Benedikt M Kessler; Udo Oppermann
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(19):7745-50.
2011: Tobias Krojer; Frank von Delft
Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects.
Journal of synchrotron radiation 2011;18(Pt 3):387-97.
2011: Linda Truebestein; Annette Tennstaedt; Timon Mönig; Tobias Krojer; Flavia Canellas; Markus Kaiser; Tim Clausen; Michael Ehrmann
Substrate-induced remodeling of the active site regulates human HTRA1 activity.
Nature structural & molecular biology 2011;18(3):386-8.
2010: Monica Mantri; Tobias Krojer; Eleanor A Bagg; Celia J Webby; Danica S Butler; Grazyna Kochan; Kathryn L Kavanagh; Udo Oppermann; Michael McDonough; Christopher J Schofield
Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.
Journal of molecular biology 2010;401(2):211-22.
2010: Tobias Krojer; Justyna Sawa; Robert Huber; Tim Clausen
HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues.
Nature structural & molecular biology 2010;17(7):844-52.
2009: Michael Meltzer; Sonja Hasenbein; Nicolette Mamant; Melisa Merdanovic; Simon Poepsel; Patrick Hauske; Markus Kaiser; Robert Huber; Tobias Krojer; Tim Clausen; Michael Ehrmann
Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli.
Research in microbiology 2009;160(9):660-6.
2009: Patrick Hauske; Michael Meltzer; Christian Ottmann; Tobias Krojer; Tim Clausen; Michael Ehrmann; Markus Kaiser
Selectivity profiling of DegP substrates and inhibitors.
Bioorganic & medicinal chemistry 2009;17(7):2920-4.
2008: Tobias Krojer; Justyna Sawa; Eva Schäfer; Helen R Saibil; Michael Ehrmann; Tim Clausen
Structural basis for the regulated protease and chaperone function of DegP.
Nature 2008;453(7197):885-90.
2008: Tobias Krojer; Karen Pangerl; Juliane Kurt; Justyna Sawa; Christoph Stingl; Karl Mechtler; Robert Huber; Michael Ehrmann; Tim Clausen
Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7702-7.
2008: Michael Meltzer; Sonja Hasenbein; Patrick Hauske; Nicolette Kucz; Melisa Merdanovic; Sandra Grau; Alexandra Beil; Dafydd Jones; Tobias Krojer; Tim Clausen; Michael Ehrmann; Markus Kaiser
Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control.
Angewandte Chemie (International ed. in English) 2008;47(7):1332-4.
2007: Hanna Hasselblatt; Robert Kurzbauer; Corinna Wilken; Tobias Krojer; Justyna Sawa; Juliane Kurt; Rebecca Kirk; Sonja Hasenbein; Michael Ehrmann; Tim Clausen
Regulation of the sigmaE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress.
Genes & development 2007;21(20):2659-70.
2006: Lorenz Chatwell; Tobias Krojer; Alexander Fidler; Werner Römisch; Wolfgang Eisenreich; Adelbert Bacher; Robert Huber; Markus Fischer
Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii.
Journal of molecular biology 2006;359(5):1334-51.
2006: Arne Ramsperger; Martin Augustin; Anne-Kathrin Schott; Stefan Gerhardt; Tobias Krojer; Wolfgang Eisenreich; Boris Illarionov; Mark Cushman; Adelbert Bacher; Robert Huber; Markus Fischer
Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications.
The Journal of biological chemistry 2006;281(2):1224-32.
2002: Tobias Krojer; Marta Garrido-Franco; Robert Huber; Michael Ehrmann; Tim Clausen
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine.
Nature 2002;416(6879):455-9.