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Hans Krokan

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TOP 3
Hans E Krokan; Magnar Bjørås
Base excision repair.
Javier Peña-Diaz; Per Arne Aas; Endre Anderssen; Finn Drabløs; Gregor Gilfillan; Siv A Hegre; Hans E Krokan; Robert Lyle; Robin Mjelle; Pål Saetrom
Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication.
Cathrine B Vågbø; Eva K Svaasand; Per Arne Aas; Hans E Krokan
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.

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All Publications

2013: Hans E Krokan; Magnar Bjørås
Base excision repair.
Cold Spring Harbor perspectives in biology 2013;5(4):a012583.
2013: Javier Peña-Diaz; Per Arne Aas; Endre Anderssen; Finn Drabløs; Gregor Gilfillan; Siv A Hegre; Hans E Krokan; Robert Lyle; Robin Mjelle; Pål Saetrom
Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication.
Nucleic acids research 2013;41(5):2846-56.
2013: Cathrine B Vågbø; Eva K Svaasand; Per Arne Aas; Hans E Krokan
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.
DNA repair 2013;12(3):188-95.
2013: Yi Hu; Javier Di noia; Ida Ericsson; Hans E Krokan; Nina Beate Liabakk; Stephen P Methot; Geir Slupphaug; Ottar Sundheim; Kathrin Torseth; Bodil Kavli
A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.
Journal of molecular biology 2013;425(2):424-43.
2013: Guanqun Zheng; Florian Bogdan; Ralph P G Bosmans; John Arne Dahl; Qing Dai; Peter Fedorcsak; Ye Fu; Kari Furu; Ya-Juan Hao; Chun-Min Huang; Guifang Jia; Arne Klungland; Hans E Krokan; Charles J Li; Jun Liu; Zhike Lu; Yamei Niu; Yue Shi; Shu-Hui Song; Wei-Min Tong; Cathrine B Vågbø; Wen-Ling Wang; Xiu-Jie Wang; Xin Yang; Yun-Gui Yang; Wen-Ming Zhao; Xu Zhao; Chuan He
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Molecular cell 2013;49(1):18-29.
2013: Siv A Hegre; Marit Otterlei; Henrik Sahin Pettersen; Pål Saetrom; Per Arne Aas; Hans E Krokan
Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase.
DNA repair 2013;12(1):80-6.
2012: Trine J Meza; Marivi N Moen; Cathrine B Vågbø; Paul Grini; Arne Klungland; Hans E Krokan; Pål Ø Falnes
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Nucleic acids research 2012;40(14):6620-31.
2012: Mansour Akbari; Hans E Krokan
Base excision repair efficiency and mechanism in nuclear extracts are influenced by the ratio between volume of nuclear extraction buffer and nuclei-implications for comparative studies.
Mutation research 2012;736(1-2):33-8.
2012: Kathrin Torseth; Berit Doseth; Anne Durandy; Heidi Græsmann; Lars Hagen; Bodil Kavli; Hans E Krokan; Nina Beate Liabakk; Camilla Olaisen; Marit Otterlei; Geir Slupphaug
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA repair 2012;11(6):559-69.
2012: Berit Doseth; Cecilie Ekre; Hans E Krokan; Geir Slupphaug; Bodil Kavli
Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.
DNA repair 2012;11(6):587-93.
2012: Rémi Kazma; Hans E Krokan; Mark Lathrop; John R McLaughlin; Andres Metspalu; Alain Sarasin; Frank Skorpen; Kristjan Välk; Tõnu Vooder; Endre Anderssen; Marie-Claude Babron; Simone Benhamou; Paul Brennan; Maiken B Elvestad; John K Field; Valerie Gaborieau; Emmanuelle Génin; Rayjean J Hung
Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium.
Carcinogenesis 2012;33(5):1059-64.
2012: Hans E Krokan
Autobiographical sketch: A life in DNA repair—and beyond.
DNA repair 2012;11(3):224-35.
2011: Audun Hanssen-Bauer; Hans E Krokan; Mansour Akbari; Sonja Andersen; Javier Peña-Diaz; Geir Slupphaug; Karin Solvang-Garten; Ottar Sundheim; David M Wilson; Marit Otterlei
XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage.
Environmental and molecular mutagenesis 2011;52(8):623-35.
2011: Henrik Sahin Pettersen; Geir Slupphaug; Eva K Svaasand; Cathrine B Vågbø; Torkild Visnes; Berit Doseth; Bodil Kavli; Hans E Krokan
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic acids research 2011;39(19):8430-44.
2011: Vibeke Leihne; Trine J Meza; Cathrine B Vågbø; Erwin van den Born; Paul Grini; Finn Kirpekar; Hans E Krokan; Pål Ø Falnes
Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.
Nucleic acids research 2011;39(17):7688-701.
2011: Yan Baglo; Lars Hagen; Sissel Håvåg; Linda Helander; Hans E Krokan; Geir Slupphaug; Mirta M L Sousa; Kamila A Zub; Odrun A Gederaas
Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2011;10(7):1137-45.
2011: Berit Doseth; Torkild Visnes; Anders Wallenius; Ida Ericsson; Antonio Sarno; Henrik Sahin Pettersen; Arnar Flatberg; Tara Catterall; Geir Slupphaug; Hans E Krokan; Bodil Kavli
Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.
The Journal of biological chemistry 2011;286(19):16669-80.
2011: Adam B Robertson; John A Dahl; Cathrine B Vågbø; Pankaj Tripathi; Hans E Krokan; Arne Klungland
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic acids research 2011;39(8):e55.
2011: Carl-Jørgen Arum; Odrun A Gederaas; Eivind L P Larsen; Lise L Randeberg; Astrid Hjelde; Hans E Krokan; Lars O Svaasand; Duan Chen; Chunmei Zhao
Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of action.
Journal of biomedical optics 2011;16(2):028001.
2011: Erwin van den Born; Cathrine B Vågbø; Lene Songe-Møller; Vibeke Leihne; Guro F Lien; Grazyna Leszczynska; Andrzej Malkiewicz; Hans E Krokan; Finn Kirpekar; Arne Klungland; Pål Ø Falnes
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nature communications 2011;2():172.
2010: Vivi Talstad Monsen; Ottar Sundheim; Per Arne Aas; Marianne P Westbye; Mirta M L Sousa; Geir Slupphaug; Hans E Krokan
Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3.
Nucleic acids research 2010;38(19):6447-55.
2010: Mansour Akbari; Karin Solvang-Garten; Audun Hanssen-Bauer; Nora Valeska Lieske; Henrik Sahin Pettersen; Grete Klippenvåg Pettersen; David M Wilson; Hans E Krokan; Marit Otterlei
Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.
DNA repair 2010;9(7):785-95.
2010: Lene Songe-Møller; Erwin van den Born; Vibeke Leihne; Cathrine B Vågbø; Terese Kristoffersen; Hans E Krokan; Finn Kirpekar; Pål Ø Falnes; Arne Klungland
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.
Molecular and cellular biology 2010;30(7):1814-27.
2010: Jens E Slagsvold; Caroline H H Pettersen; Gro L Størvold; Turid Follestad; Hans E Krokan; Svanhild Arentz Schønberg
DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells.
Nutrition and cancer 2010;62(5):611-21.
2009: Karin M Gilljam; Emadoldin Feyzi; Per A Aas; Mirta M L Sousa; Rebekka Müller; Cathrine B Vågbø; Tara C Catterall; Nina B Liabakk; Geir Slupphaug; Finn Drabløs; Hans E Krokan; Marit Otterlei
Identification of a novel, widespread, and functionally important PCNA-binding motif.
The Journal of cell biology 2009;186(5):645-54.
2009: Gro Leite Størvold; Karianne Giller Fleten; Cathrine Goberg Olsen; Turid Follestad; Hans E Krokan; Svanhild Arentz Schønberg
Docosahexaenoic acid activates some SREBP-2 targets independent of cholesterol and ER stress in SW620 colon cancer cells.
Lipids 2009;44(8):673-83.
2009: Mansour Akbari; Javier Peña-Diaz; Sonja Andersen; Nina Beate Liabakk; Marit Otterlei; Hans E Krokan
Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity.
DNA repair 2009;8(7):834-43.
2009: Per Arne Aas; Javier Peña-Diaz; Nina Beate Liabakk; Hans E Krokan; Frank Skorpen
Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression.
DNA repair 2009;8(7):822-33.
2009: Torkild Visnes; Berit Doseth; Henrik Sahin Pettersen; Lars Hagen; Mirta M L Sousa; Mansour Akbari; Marit Otterlei; Bodil Kavli; Geir Slupphaug; Hans E Krokan
Uracil in DNA and its processing by different DNA glycosylases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1517):563-8.
2009: Jens Erik Slagsvold; Caroline Hild Hakvåg Pettersen; Turid Follestad; Hans E Krokan; Svanhild Arentz Schønberg
The antiproliferative effect of EPA in HL60 cells is mediated by alterations in calcium homeostasis.
Lipids 2009;44(2):103-13.
2008: Simon Heath; Ivo Gut; Paul Brennan; James D McKay; Vladimir Bencko; Eleonora Fabianova; Lenka Foretova; Michael Georges; vladimir janout; Michael Kabesch; Hans E Krokan; Maiken B Elvestad; Jolanta Lissowska; Dana Mates; Peter Rudnai; Frank Skorpen; Stefan Schreiber; José M Soria; Ann-Christine Syvänen; Pierre Meneton; Serge Herçberg; Pilar Galan; Neonilia Szeszenia-Dabrowska; David Zaridze; Emmanuel Génin; Lon R Cardon; Mark Lathrop
Investigation of the fine structure of European populations with applications to disease association studies.
European journal of human genetics : EJHG 2008;16(12):1413-29.
2008: Tone F Bathen; Kristin Holmgren; Anne Gøril Lundemo; Mari H B Hjelstuen; Hans E Krokan; Ingrid S Gribbestad; Svanhild A Schønberg
Omega-3 fatty acids suppress growth of SW620 human colon cancer xenografts in nude mice.
Anticancer research 2008;28(6A):3717-23.
2008: Ottar Sundheim; Vivi A Talstad; Cathrine B Vågbø; Geir Slupphaug; Hans E Krokan
AlkB demethylases flip out in different ways.
DNA repair 2008;7(11):1916-23.
2008: Torkild Visnes; Mansour Akbari; Lars Hagen; Geir Slupphaug; Hans E Krokan
The rate of base excision repair of uracil is controlled by the initiating glycosylase.
DNA repair 2008;7(11):1869-81.
2008: Caroline Hild Jakobsen; Gro Leite Størvold; Hilde Bremseth; Turid Follestad; Kristin Sand; Merete Mack; Karina Standahl Olsen; Anne Gøril Lundemo; Jens-Gustav Iversen; Hans E Krokan; Svanhild Arentz Schønberg
DHA induces ER stress and growth arrest in human colon cancer cells: associations with cholesterol and calcium homeostasis.
Journal of lipid research 2008;49(10):2089-100.
2008: Marianne Pedersen Westbye; Emadoldin Feyzi; Per Arne Aas; Cathrine B Vågbø; Vivi Anita Talstad; Bodil Kavli; Lars Hagen; Ottar Sundheim; Mansour Akbari; Nina Beate Liabakk; Geir Slupphaug; Marit Otterlei; Hans E Krokan
Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.
The Journal of biological chemistry 2008;283(36):25046-56.
2008: Eivind L P Larsen; Lise L Randeberg; Odrun A Gederaas; Carl-Jørgen Arum; Astrid Hjelde; Chunmei Zhao; Duan Chen; Hans E Krokan; Lars O Svaasand
Monitoring of hexyl 5-aminolevulinate-induced photodynamic therapy in rat bladder cancer by optical spectroscopy.
Journal of biomedical optics 2008;13(4):044031.
2008: Mansour Akbari; Hans E Krokan
Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging.
Mechanisms of ageing and development 2008;129(7-8):353-65.
2008: Mansour Akbari; Torkild Visnes; Hans E Krokan; Marit Otterlei
Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.
DNA repair 2008;7(4):605-16.
2008: Lars Hagen; Bodil Kavli; Mirta M L Sousa; Kathrin Torseth; Nina Beate Liabakk; Ottar Sundheim; Javier Pena-Diaz; Marit Otterlei; Ole Hørning; Ole N Jensen; Hans E Krokan; Geir Slupphaug
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
The EMBO journal 2008;27(1):51-61.
2007: Emadoldin Feyzi; Ottar Sundheim; Marianne Pedersen Westbye; Per Arne Aas; Cathrine B Vågbø; Marit Otterlei; Geir Slupphaug; Hans E Krokan
RNA base damage and repair.
Current pharmaceutical biotechnology 2007;8(6):326-31.
2007: Mirta M L Sousa; Hans E Krokan; Geir Slupphaug
DNA-uracil and human pathology.
Molecular aspects of medicine 2007;28(3-4):276-306.
2007: Mansour Akbari; Marit Otterlei; Javier Peña-Diaz; Hans E Krokan
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.
Neuroscience 2007;145(4):1201-12.
2007: Bodil Kavli; Marit Otterlei; Geir Slupphaug; Hans E Krokan
Uracil in DNA--general mutagen, but normal intermediate in acquired immunity.
DNA repair 2007;6(4):505-16.
2007: Henrik Sahin Pettersen; Ottar Sundheim; Karin Margaretha Gilljam; Geir Slupphaug; Hans E Krokan; Bodil Kavli
Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms.
Nucleic acids research 2007;35(12):3879-92.
2006: Lars Hagen; Javier Peña-Diaz; Bodil Kavli; Marit Otterlei; Geir Slupphaug; Hans E Krokan
Genomic uracil and human disease.
Experimental cell research 2006;312(14):2666-72.
2006: Ottar Sundheim; Cathrine B Vågbø; Magnar Bjørås; Mirta M L Sousa; Vivi Talstad; Per Arne Aas; Finn Drabløs; Hans E Krokan; John A Tainer; Geir Slupphaug
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
The EMBO journal 2006;25(14):3389-97.
2006: Svanhild Arentz Schønberg; Anne G Lundemo; Torill Fladvad; Kristin Holmgren; Hilde Bremseth; Asbjørn Nilsen; Odrun A Gederaas; Kåre E Tvedt; Kjartan W Egeberg; Hans E Krokan
Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1.
The FEBS journal 2006;273(12):2749-65.
2006: Jeanette Ringvoll; Line M Nordstrand; Cathrine B Vågbø; Vivi Talstad; Karen Reite; Per Arne Aas; Knut H Lauritzen; Nina Beate Liabakk; Alexandra Bjork-Skaflestad; Richard William Doughty; Pål Ø Falnes; Hans E Krokan; Arne Klungland
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.
The EMBO journal 2006;25(10):2189-98.
2005: Sonja Andersen; Madelene Ericsson; Hong Yan Dai; Javier Peña-Diaz; Geir Slupphaug; Hilde Nilsen; Harald Aarset; Hans E Krokan
Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice.
DNA repair 2005;4(12):1432-41.
2005: Paul Auerbach; Richard A O Bennett; Elisabeth A Bailey; Hans E Krokan; Bruce Demple
Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(49):17711-6.
2005: Astrid Hjelde; Odrun A Gederaas; Hans E Krokan; Alf O Brubakk
Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines.
Medical science monitor : international medical journal of experimental and clinical research 2005;11(10):BR351-6.
2005: Trude Teoline Rakvåg; Pål Klepstad; Cecilie Baar; Tor-Morten Kvam; Ola Dale; Stein Kaasa; Hans E Krokan; Frank Skorpen
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients.
Pain 2005;116(1-2):73-8.
2005: Bodil Kavli; Sonja Andersen; Marit Otterlei; Nina Beate Liabakk; Kohsuke Imai; Alain Fischer; Anne Durandy; Hans E Krokan; Geir Slupphaug
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
The Journal of experimental medicine 2005;201(12):2011-21.
2005: Odrun A Gederaas; Svanhild Arentz Schønberg; Ståle Ramstad; Kristian Berg; Anders Johnsson; Hans E Krokan
Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2005;4(4):383-9.
2005: Sonja Andersen; Tina Heine; Ragnhild Sneve; Imbritt König; Hans E Krokan; Bernd Epe; Hilde Nilsen
Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts.
Carcinogenesis 2005;26(3):547-55.
2005: Mansour Akbari; Marianne Doré Hansen; Jostein Halgunset; Frank Skorpen; Hans E Krokan
Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner.
The Journal of molecular diagnostics : JMD 2005;7(1):36-9.
2004: Finn Drabløs; Emadoldin Feyzi; Per Arne Aas; Cathrine B Vaagbø; Bodil Kavli; Marit S Bratlie; Javier Peña-Diaz; Marit Otterlei; Geir Slupphaug; Hans E Krokan
Alkylation damage in DNA and RNA--repair mechanisms and medical significance.
DNA repair 2004;3(11):1389-407.
2004: Pål Klepstad; Trude Teoline Rakvåg; Stein Kaasa; Monica Holthe; Ola Dale; Petter C Borchgrevink; Cecilie Baar; T Vikan; Hans E Krokan; Frank Skorpen
The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease.
Acta anaesthesiologica Scandinavica 2004;48(10):1232-9.
2004: Javier Peña-Diaz; Mansour Akbari; Ottar Sundheim; M Esther Farez-Vidal; Sonja Andersen; Ragnhild Sneve; Dolores Gonzalez-Pacanowska; Hans E Krokan; Geir Slupphaug
Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair.
Journal of molecular biology 2004;342(3):787-99.
2004: Hans E Krokan; Bodil Kavli; Geir Slupphaug
Novel aspects of macromolecular repair and relationship to human disease.
Journal of molecular medicine (Berlin, Germany) 2004;82(5):280-97.
2004: Mansour Akbari; CF Skjelbred; Ivar Følling; J Sagen; Hans E Krokan
A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA(Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss.
Scandinavian journal of clinical and laboratory investigation 2004;64(2):86-92.
2004: Tor-Morten Kvam; Cecilie Baar; Trude Teoline Rakvåg; Stein Kaasa; Hans E Krokan; Frank Skorpen
Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing.
Journal of molecular medicine (Berlin, Germany) 2004;82(4):250-5.
2004: Mansour Akbari; Marit Otterlei; Javier Peña-Diaz; Per Arne Aas; Bodil Kavli; Nina Beate Liabakk; Lars Hagen; Kohsuke Imai; Anne Durandy; Geir Slupphaug; Hans E Krokan
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells.
Nucleic acids research 2004;32(18):5486-98.
2003: Geir Slupphaug; Bodil Kavli; Hans E Krokan
The interacting pathways for prevention and repair of oxidative DNA damage.
Mutation research 2003;531(1-2):231-51.
2003: Kohsuke Imai; Geir Slupphaug; Wen-I Lee; Patrick Revy; Shigeaki Nonoyama; Nadia Catalan; Leman Yel; Monique Forveille; Bodil Kavli; Hans E Krokan; Hans D Ochs; Alain Fischer; Anne Durandy
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.
Nature immunology 2003;4(10):1023-8.
2003: Hilde Nilsen; Gordon Stamp; Sonja Andersen; Geza Hrivnak; Hans E Krokan; Tomas Lindahl; Deborah E Barnes
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas.
Oncogene 2003;22(35):5381-6.
2003: Per Arne Aas; Marit Otterlei; Pål O Falnes; Cathrine B Vågbø; Frank Skorpen; Mansour Akbari; Ottar Sundheim; Magnar Bjørås; Geir Slupphaug; Erling Seeberg; Hans E Krokan
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.
Nature 2003;421(6925):859-63.
2003: Monica Holthe; T N Rakvåg; Pål Klepstad; JR Idle; Stein Kaasa; Hans E Krokan; Frank Skorpen
Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients.
The pharmacogenomics journal 2003;3(1):17-26.
2002: Hans E Krokan; Finn Drabløs; Geir Slupphaug
Uracil in DNA--occurrence, consequences and repair.
Oncogene 2002;21(58):8935-48.
2002: Bodil Kavli; Ottar Sundheim; Mansour Akbari; Marit Otterlei; Hilde Nilsen; Frank Skorpen; Per Arne Aas; Lars Hagen; Hans E Krokan; Geir Slupphaug
hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup.
The Journal of biological chemistry 2002;277(42):39926-36.
2002: Monica Holthe; Pål Klepstad; Kolbjørn Zahlsen; Petter C Borchgrevink; Lars Hagen; Ola Dale; Stein Kaasa; Hans E Krokan; Frank Skorpen
Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy.
European journal of clinical pharmacology 2002;58(5):353-6.
2001: Hilde Nilsen; Hans E Krokan
Base excision repair in a network of defence and tolerance.
Carcinogenesis 2001;22(7):987-98.
2001: Hans E Krokan; H Prydz
[Gene transfer--ways of administration, advantages, possible unsuitability and hazards].
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 2001;121(4):479-82.
2001: K Kvaløy; Hilde Nilsen; KS Steinsbekk; Aina Nedal; B Monterotti; Mansour Akbari; Hans E Krokan
Sequence variation in the human uracil-DNA glycosylase (UNG) gene.
Mutation research 2001;461(4):325-38.
2001: Hans E Krokan; Marit Otterlei; Hilde Nilsen; Bodil Kavli; Frank Skorpen; Sonja Andersen; CF Skjelbred; Mansour Akbari; Per Arne Aas; Geir Slupphaug
Properties and functions of human uracil-DNA glycosylase from the UNG gene.
Progress in nucleic acid research and molecular biology 2001;68():365-86.
2001: PK Rudra; Hans E Krokan
Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid.
Anticancer research 2001;21(1A):29-38.
2000: Marit Otterlei; Bodil Kavli; R Standal; CF Skjelbred; S Bharati; Hans E Krokan
Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.
The EMBO journal 2000;19(20):5542-51.
2000: Hans E Krokan; Hilde Nilsen; Frank Skorpen; Marit Otterlei; Geir Slupphaug
Base excision repair of DNA in mammalian cells.
FEBS letters 2000;476(1-2):73-7.
2000: Hilde Nilsen; KS Steinsbekk; Marit Otterlei; Geir Slupphaug; Per Arne Aas; Hans E Krokan
Analysis of uracil-DNA glycosylases from the murine Ung gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues.
Nucleic acids research 2000;28(12):2277-85.
2000: Hilde Nilsen; Ian Rosewell; Peter Robins; CF Skjelbred; Sonja Andersen; Geir Slupphaug; Graham Daly; Hans E Krokan; Tomas Lindahl; Deborah E Barnes
Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication.
Molecular cell 2000;5(6):1059-65.
2000: SS Parikh; G Walcher; G D Jones; Geir Slupphaug; Hans E Krokan; G M Blackburn; John A Tainer
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5083-8.
1999: Marit Otterlei; Emma Warbrick; TA Nagelhus; T Haug; Geir Slupphaug; Mansour Akbari; Per Arne Aas; KS Steinsbekk; Oddmund Bakke; Hans E Krokan
Post-replicative base excision repair in replication foci.
The EMBO journal 1999;18(13):3834-44.
1999: PK Rudra; Hans E Krokan
Acrolein cytotoxicity and glutathione depletion in n-3 fatty acid sensitive- and resistant human tumor cells.
Anticancer research 1999;19(1A):461-9.
1998: S Bharati; Hans E Krokan; LI Kristiansen; Marit Otterlei; Geir Slupphaug
Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites.
Nucleic acids research 1998;26(21):4953-9.
1998: Marit Otterlei; T Haug; TA Nagelhus; Geir Slupphaug; Tore Lindmo; Hans E Krokan
Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively.
Nucleic acids research 1998;26(20):4611-7.
1998: SS Parikh; Clifford D Mol; Geir Slupphaug; S Bharati; Hans E Krokan; John A Tainer
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
The EMBO journal 1998;17(17):5214-26.
1998: Frank Skorpen; CF Skjelbred; B Alm; Per Arne Aas; Svanhild Arentz Schønberg; Hans E Krokan
Repair of cyclobutane pyrimidine dimers in the O6-methylguanine-DNA methyltransferase (MGMT) gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus.
Mutation research 1998;407(3):227-41.
1998: Hans E Krokan; Geir Slupphaug
[DNA repair enzymes and their genes].
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1998;118(13):2037-42.
1998: T Haug; Frank Skorpen; Per Arne Aas; V Malm; CF Skjelbred; Hans E Krokan
Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase.
Nucleic acids research 1998;26(6):1449-57.
1998: Frank Skorpen; B Alm; CF Skjelbred; Per Arne Aas; Hans E Krokan
Paracetamol increases sensitivity to ultraviolet (UV) irradiation, delays repair of the UNG-gene and recovery of RNA synthesis in HaCaT cells.
Chemico-biological interactions 1998;110(1-2):123-36.
1998: R Nøding; Svanhild Arentz Schønberg; Hans E Krokan; Kristian S. Bjerve
Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media.
Lipids 1998;33(3):285-93.
1997: Svanhild Arentz Schønberg; PK Rudra; R Nøding; Frank Skorpen; Kristian S. Bjerve; Hans E Krokan
Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids.
Carcinogenesis 1997;18(10):1897-904.
1997: Hans E Krokan; R Standal; Geir Slupphaug
DNA glycosylases in the base excision repair of DNA.
The Biochemical journal 1997;325 ( Pt 1)():1-16.
1997: TA Nagelhus; T Haug; K K Singh; K F Keshav; Frank Skorpen; Marit Otterlei; S Bharati; Tore Lindmo; Serge Benichou; Richard Benarous; Hans E Krokan
A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A.
The Journal of biological chemistry 1997;272(10):6561-6.
1997: Hilde Nilsen; Marit Otterlei; T Haug; K Solum; TA Nagelhus; Frank Skorpen; Hans E Krokan
Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene.
Nucleic acids research 1997;25(4):750-5.
1996: Geir Slupphaug; Clifford D Mol; B Kavli; Andrew S Arvai; Hans E Krokan; John A Tainer
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature 1996;384(6604):87-92.
1996: T Haug; Frank Skorpen; K Kvaløy; Ingrid Eftedal; H Lund; Hans E Krokan
Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1.
Genomics 1996;36(3):408-16.
1996: H Lund; Ingrid Eftedal; T Haug; Hans E Krokan
Pseudogenes for the human uracil-DNA glycosylase on chromosomes 14 and 16.
Biochemical and biophysical research communications 1996;224(1):265-70.
1996: B Kavli; Geir Slupphaug; Clifford D Mol; Andrew S Arvai; S B Peterson; John A Tainer; Hans E Krokan
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
The EMBO journal 1996;15(13):3442-7.
1996: TA Nagelhus; Geir Slupphaug; Hans E Krokan; Tore Lindmo
Fading correction for fluorescence quantitation in confocal microscopy.
Cytometry 1996;23(3):187-95.
1996: Miral Dizdaroglu; A Karakaya; Pawel Jaruga; Geir Slupphaug; Hans E Krokan
Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage.
Nucleic acids research 1996;24(3):418-22.
1995: TA Nagelhus; Geir Slupphaug; Tore Lindmo; Hans E Krokan
Cell cycle regulation and subcellular localization of the major human uracil-DNA glycosylase.
Experimental cell research 1995;220(2):292-7.
1995: Clifford D Mol; Andrew S Arvai; R J Sanderson; Geir Slupphaug; B Kavli; Hans E Krokan; Dale W Mosbaugh; John A Tainer
Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA.
Cell 1995;82(5):701-8.
1995: Frank Skorpen; Hans E Krokan
The methylation status of the gene for O6-methylguanine-DNA methyltransferase in human Mer+ and Mer- cells.
Carcinogenesis 1995;16(8):1857-63.
1995: Svanhild Arentz Schønberg; Hans E Krokan
The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation.
Anticancer research 1995;15(4):1241-6.
1995: H Nilsen; S P Yazdankhah; Ingrid Eftedal; Hans E Krokan
Sequence specificity for removal of uracil from U.A pairs and U.G mismatches by uracil-DNA glycosylase from Escherichia coli, and correlation with mutational hotspots.
FEBS letters 1995;362(2):205-9.
1995: L Maehle; E Eilertsen; S Mollerup; Svanhild Arentz Schønberg; Hans E Krokan; Aage Haugen
Effects of n-3 fatty acids during neoplastic progression and comparison of in vitro and in vivo sensitivity of two human tumour cell lines.
British journal of cancer 1995;71(4):691-6.
1995: Clifford D Mol; Andrew S Arvai; Geir Slupphaug; B Kavli; I Alseth; Hans E Krokan; John A Tainer
Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis.
Cell 1995;80(6):869-78.
1995: Geir Slupphaug; Ingrid Eftedal; B Kavli; S Bharati; N M Helle; T Haug; D W Levine; Hans E Krokan
Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase.
Biochemistry 1995;34(1):128-38.
1994: T Haug; Frank Skorpen; H Lund; Hans E Krokan
Structure of the gene for human uracil-DNA glycosylase and analysis of the promoter function.
FEBS letters 1994;353(2):180-4.
1994: Ingrid Eftedal; G Volden; Hans E Krokan
Excision of uracil from double-stranded DNA by uracil-DNA glycosylase is sequence specific.
Annals of the New York Academy of Sciences 1994;726():312-4.
1994: Frank Skorpen; Hans E Krokan
BglII polymorphism in the UNG gene in 4 populations.
Human molecular genetics 1994;3(3):522.
1993: Geir Slupphaug; F H Markussen; L C Olsen; Rein Aasland; N Aarsaether; O Bakke; Hans E Krokan; D E Helland
Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene.
Nucleic acids research 1993;21(11):2579-84.
1993: Hans E Krokan; Kristian S. Bjerve; E Mørk
The enteral bioavailability of eicosapentaenoic acid and docosahexaenoic acid is as good from ethyl esters as from glyceryl esters in spite of lower hydrolytic rates by pancreatic lipase in vitro.
Biochimica et biophysica acta 1993;1168(1):59-67.
1993: Geir Slupphaug; I Alseth; Ingrid Eftedal; G Volden; Hans E Krokan
Low incorporation of dUMP by some thermostable DNA polymerases may limit their use in PCR amplifications.
Analytical biochemistry 1993;211(1):164-9.
1993: Ingrid Eftedal; P H Guddal; Geir Slupphaug; G Volden; Hans E Krokan
Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase.
Nucleic acids research 1993;21(9):2095-101.
1992: Geir Slupphaug; I Lettrem; B Myrnes; Hans E Krokan
Expression of O6-methylguanine--DNA methyltransferase and uracil--DNA glycosylase in human placentae from smokers and non-smokers.
Carcinogenesis 1992;13(10):1769-73.
1991: Geir Slupphaug; L C Olsen; D Helland; Rein Aasland; Hans E Krokan
Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil-DNA glycosylase.
Nucleic acids research 1991;19(19):5131-7.
1991: L C Olsen; Rein Aasland; Hans E Krokan; D E Helland
Human uracil-DNA glycosylase complements E. coli ung mutants.
Nucleic acids research 1991;19(16):4473-8.
1990: Rein Aasland; L C Olsen; N K Spurr; Hans E Krokan; D E Helland
Chromosomal assignment of human uracil-DNA glycosylase to chromosome 12.
Genomics 1990;7(1):139-41.
1990: Hans E Krokan; L C Olsen; Rein Aasland; G Volden; G Eggset; B Myrnes; B Johansen; A Haugen; D E Helland
DNA repair in mammalian tissues and cells.
Basic life sciences 1990;53():175-90.
1990: B I Haukanes; Paul W. Doetsch; L C Olsen; I Huq; Hans E Krokan; D E Helland
Damage specific mammalian endonucleases.
Basic life sciences 1990;53():191-202.
1989: L C Olsen; Rein Aasland; C U Wittwer; Hans E Krokan; D E Helland
Molecular cloning of human uracil-DNA glycosylase, a highly conserved DNA repair enzyme.
The EMBO journal 1989;8(10):3121-5.
1989: C U Wittwer; G Bauw; Hans E Krokan
Purification and determination of the NH2-terminal amino acid sequence of uracil-DNA glycosylase from human placenta.
Biochemistry 1989;28(2):780-4.
1985: C U Wittwer; Hans E Krokan
Uracil-DNA glycosylase in HeLa S3 cells: interconvertibility of 50 and 20 kDa forms and similarity of the nuclear and mitochondrial form of the enzyme.
Biochimica et biophysica acta 1985;832(3):308-18.
1985: T Deilhaug; B Myrnes; T Aune; Hans E Krokan; A Haugen
Differential capacities for DNA repair in Clara cells, alveolar type II cells and macrophages of rabbit lung.
Carcinogenesis 1985;6(4):661-3.
1984: B Myrnes; K Norstrand; K E Giercksky; C Sjunneskog; Hans E Krokan
A simplified assay for O6-methylguanine-DNA methyltransferase activity and its application to human neoplastic and non-neoplastic tissues.
Carcinogenesis 1984;5(8):1061-4.
1984: B Myrnes; G Eggset; G Volden; Hans E Krokan
Enzymatic repair of premutagenic DNA lesions in human epidermis. Quantitation of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activities.
Mutation research 1984;131(3-4):183-6.
1983: B Myrnes; K E Giercksky; Hans E Krokan
Interindividual variation in the activity of O6-methyl guanine-DNA methyltransferase and uracil-DNA glycosylase in human organs.
Carcinogenesis 1983;4(12):1565-8.
1983: Hans E Krokan; A Haugen; B Myrnes; P H Guddal
Repair of premutagenic DNA lesions in human fetal tissues: evidence for low levels of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activity in some tissues.
Carcinogenesis 1983;4(12):1559-64.
1983: D Helland; Hans E Krokan
UV-irradiated SV40 minichromosomes as substrates for DNA repair endonucleases.
Biochemical and biophysical research communications 1983;113(1):309-16.
1983: G Eggset; G Volden; Hans E Krokan
U.v.-induced DNA damage and its repair in human skin in vivo studied by sensitive immunohistochemical methods.
Carcinogenesis 1983;4(6):745-50.
1982: B Myrnes; P H Guddal; Hans E Krokan
Metabolism of dITP in HeLa cell extracts, incorporation into DNA by isolated nuclei and release of hypoxanthine from DNA by a hypoxanthine-DNA glycosylase activity.
Nucleic acids research 1982;10(12):3693-701.
1982: B Myrnes; K E Giercksky; Hans E Krokan
Repair of O6-methyl-guanine residues in DNA takes place by a similar mechanism in extracts from HeLa cells, human liver, and rat liver.
Journal of cellular biochemistry 1982;20(4):381-92.
1981: Hans E Krokan; C U Wittwer
Uracil DNa-glycosylase from HeLa cells: general properties, substrate specificity and effect of uracil analogs.
Nucleic acids research 1981;9(11):2599-613.