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Stephen Kron

Research Profile

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Saccharomyces cerevisiae

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Phosphorylation

Chemicals & Drugs

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DNA Damage

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Publications

TOP 3
Gargi Ghosh; Stephen J Kron; Xiaoliang Yan; Sean P Palecek
Activity assay of epidermal growth factor receptor tyrosine kinase inhibitors in triple-negative breast cancer cells using peptide-conjugated magnetic beads.
Andrew W Truman; Donald Wolfgeher; Hong Zhang; Sarah Perrett; Sigrun Polier; Chrisostomos Prodromou; Naushaba Hasin; Gary W Jones; Kolbrun Kristjansdottir; Stephen J Kron
CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression.
Guangchang Zhou; Juliesta E Sylvester; Qing Dai; Faraz Khan; Stephen J Kron
Photocleavable peptide-oligonucleotide conjugates for protein kinase assays by MALDI-TOF MS.

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All Publications

2013: Gargi Ghosh; Stephen J Kron; Xiaoliang Yan; Sean P Palecek
Activity assay of epidermal growth factor receptor tyrosine kinase inhibitors in triple-negative breast cancer cells using peptide-conjugated magnetic beads.
Assay and drug development technologies 2013;11(1):44-51.
2012: Andrew W Truman; Donald Wolfgeher; Hong Zhang; Sarah Perrett; Sigrun Polier; Chrisostomos Prodromou; Naushaba Hasin; Gary W Jones; Kolbrun Kristjansdottir; Stephen J Kron
CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression.
Cell 2012;151(6):1308-18.
2012: Guangchang Zhou; Juliesta E Sylvester; Qing Dai; Faraz Khan; Stephen J Kron
Photocleavable peptide-oligonucleotide conjugates for protein kinase assays by MALDI-TOF MS.
Molecular bioSystems 2012;8(9):2395-404.
2012: Yuru Meng; Thomas E Darga; Elena V Efimova; Yang-Xin Fu; Khaled W Hamzeh; Stephen J Kron; Helena J Mauceri; Ralph R Weichselbaum
Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(5):1046-55.
2012: Juliesta E Sylvester; Tyler S Bray; Stephen J Kron
Annotator: postprocessing software for generating function-based signatures from quantitative mass spectrometry.
Journal of proteome research 2012;11(3):1521-36.
2012: Gargi Ghosh; Stephen J Kron; Xiaojun Lian; Sean P Palecek
Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors.
BMC cancer 2012;12():95.
2011: Juan Camilo Barreto-Andrade; Michael A Beckett; Thomas E Darga; Elena V Efimova; Stephen J Kron; Helena J Mauceri; Mitchell C Posner; Harold G Sutton; Everett E Vokes; Ralph R Weichselbaum
Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation.
Molecular cancer therapeutics 2011;10(7):1185-93.
2011: Guangchang Zhou; Juliesta E Sylvester; Ding Wu; Darren R Veach; Stephen J Kron
A magnetic bead-based protein kinase assay with dual detection techniques.
Analytical biochemistry 2011;408(1):5-11.
2010: Guangchang Zhou; Xiaoliang Yan; Ding Wu; Stephen J Kron
Photocleavable peptide-conjugated magnetic beads for protein kinase assays by MALDI-TOF MS.
Bioconjugate chemistry 2010;21(10):1917-24.
2010: Gargi Ghosh; Xiaoliang Yan; Andrew G Lee; Stephen J Kron; Sean P Palecek
Quantifying the sensitivities of EGF receptor (EGFR) tyrosine kinase inhibitors in drug resistant non-small cell lung cancer (NSCLC) cells using hydrogel-based peptide array.
Biosensors & bioelectronics 2010;26(2):424-31.
2010: Elena V Efimova; Helena J Mauceri; Daniel W Golden; Edwardine Labay; Vytautas P Bindokas; Thomas E Darga; Chaitali Chakraborty; Juan Camilo Barreto-Andrade; Clayton Crawley; Harold G Sutton; Stephen J Kron; Ralph R Weichselbaum
Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors.
Cancer research 2010;70(15):6277-82.
2010: Juliesta E Sylvester; Stephen J Kron
A bead-based activity screen for small-molecule inhibitors of signal transduction in chronic myelogenous leukemia cells.
Molecular cancer therapeutics 2010;9(5):1469-81.
2010: Ding Wu; Juliesta E Sylvester; Laurie L Parker; Guangchang Zhou; Stephen J Kron
Peptide reporters of kinase activity in whole cell lysates.
Biopolymers 2010;94(4):475-86.
2009: Chinonye C Nnakwe; Mohammed Altaf; Jacques Côté; Stephen J Kron
Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping.
DNA repair 2009;8(12):1452-61.
2009: Brian Td Tobe; Ana A Kitazono; Jacqueline S Garcia; Renee A Gerber; Brooke J Bevis; John Choy; Daniel Chasman; Stephen J Kron
Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase.
Cell division 2009;4():12.
2008: Olesya A Ulanovskaya; Jelena Janjic; Masato Suzuki; Simran S Sabharwal; Paul T Schumacker; Stephen J Kron; Sergey A Kozmin
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
Nature chemical biology 2008;4(7):418-24.
2008: Kolbrun Kristjansdottir; Donald Wolfgeher; Nick Lucius; David Sigfredo Angulo; Stephen J Kron
Phosphoprotein profiling by PA-GeLC-MS/MS.
Journal of proteome research 2008;7(7):2812-24.
2008: Ding Wu; Michael R Mand; Darren R Veach; Laurie L Parker; Bayard Clarkson; Stephen J Kron
A solid-phase Bcr-Abl kinase assay in 96-well hydrogel plates.
Analytical biochemistry 2008;375(1):18-26.
2008: Laurie Parker; Aaron Engel-Hall; Kevin Drew; George Steinhardt; Donald L Helseth; David Jabon; Timothy McMurry; David S Angulo; Stephen J Kron
Investigating quantitation of phosphorylation using MALDI-TOF mass spectrometry.
Journal of mass spectrometry : JMS 2008;43(4):518-27.
2008: Kai Bickenbach; Jula Veerapong; M Y Shao; Helena J Mauceri; Mitchell C Posner; Stephen J Kron; Ralph R Weichselbaum
Resveratrol is an effective inducer of CArG-driven TNF-alpha gene therapy.
Cancer gene therapy 2008;15(3):133-9.
2008: Laurie L Parker; Stephen J Kron
Kinase activation in circulating cells: opportunities for biomarkers for diagnosis and therapeutic monitoring.
Expert opinion on medical diagnostics 2008;2(1):33-46.
2007: Troy D McSherry; Ana A Kitazono; Ali Javaheri; Stephen J Kron; Paul R Mueller
Non-catalytic function for ATR in the checkpoint response.
Cell cycle (Georgetown, Tex.) 2007;6(16):2019-30.
2006: Laurie L Parker; Shawn B Brueggemeier; Won Jun Rhee; Ding Wu; Stephen B H Kent; Stephen J Kron; Sean P Palecek
Photocleavable peptide hydrogel arrays for MALDI-TOF analysis of kinase activity.
The Analyst 2006;131(10):1097-104.
2006: Robert Wysocki; Ali Javaheri; Kolbrun Kristjansdottir; Fei Sha; Stephen J Kron
CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage.
Nature structural & molecular biology 2006;13(10):908-14.
2006: Laurie L Parker; Josh W Kurutz; Stephen B H Kent; Stephen J Kron
Control of the yeast cell cycle with a photocleavable alpha-factor analogue.
Angewandte Chemie (International ed. in English) 2006;45(38):6322-5.
2006: Ali Javaheri; Robert Wysocki; Olivier Jobin-Robitaille; Mohammed Altaf; Jacques Côté; Stephen J Kron
Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13771-6.
2006: Johnny Kao; Michael T Milano; Ali Javaheri; Michael C Garofalo; Steven J Chmura; Ralph R Weichselbaum; Stephen J Kron
gamma-H2AX as a therapeutic target for improving the efficacy of radiation therapy.
Current cancer drug targets 2006;6(3):197-205.
2005: Johnny Kao; Barry S Rosenstein; Sheila Peters; Michael T Milano; Stephen J Kron
Cellular response to DNA damage.
Annals of the New York Academy of Sciences 2005;1066():243-58.
2005: Ding Wu; Evan Nair-Gill; Dorie A Sher; Laurie L Parker; Jennifer M Campbell; Mariah Siddiqui; Wendy Stock; Stephen J Kron
Assaying Bcr-Abl kinase activity and inhibition in whole cell extracts by phosphorylation of substrates immobilized on agarose beads.
Analytical biochemistry 2005;347(1):67-76.
2005: Robert Wysocki; Ali Javaheri; Stéphane Allard; Fei Sha; Jacques Côté; Stephen J Kron
Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.
Molecular and cellular biology 2005;25(19):8430-43.
2005: Laurie L Parker; Alexander B Schilling; Stephen J Kron; Stephen B H Kent
Optimizing thiophosphorylation in the presence of competing phosphorylation with MALDI-TOF-MS detection.
Journal of proteome research 2005;4(5):1863-6.
2005: Shawn B Brueggemeier; Ding Wu; Stephen J Kron; Sean P Palecek
Protein-acrylamide copolymer hydrogels for array-based detection of tyrosine kinase activity from cell lysates.
Biomacromolecules 2005;6(5):2765-75.
2004: Jessica Downs; Stéphane Allard; Olivier Jobin-Robitaille; Ali Javaheri; Andréanne Auger; Nathalie Bouchard; Stephen J Kron; Stephen P Jackson; Jacques Côté
Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites.
Molecular cell 2004;16(6):979-90.
2004: Robert Wysocki; Stephen J Kron
Yeast cell death during DNA damage arrest is independent of caspase or reactive oxygen species.
The Journal of cell biology 2004;166(3):311-6.
2004: Philip P Connell; Stephen J Kron; Ralph R Weichselbaum
Relevance and irrelevance of DNA damage response to radiotherapy.
DNA repair 2004;3(8-9):1245-51.
2004: Shawn B Brueggemeier; Stephen J Kron; Sean P Palecek
Use of protein-acrylamide copolymer hydrogels for measuring protein concentration and activity.
Analytical biochemistry 2004;329(2):180-9.
2004: Neelam Taneja; Mandel Davis; John Choy; Michael A Beckett; Rachana Singh; Stephen J Kron; Ralph R Weichselbaum
Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy.
The Journal of biological chemistry 2004;279(3):2273-80.
2004: Diego Rua; Teresa M Holzen; Benjamin S Glick; Stephen J Kron; Douglas K Bishop
Monitoring changes in the subcellular location of proteins in S. cerevisiae.
Methods in molecular biology (Clifton, N.J.) 2004;241():299-311.
2003: Ana A Kitazono; D A Garza; Stephen J Kron
Mutations in the yeast cyclin-dependent kinase Cdc28 reveal a role in the spindle assembly checkpoint.
Molecular genetics and genomics : MGG 2003;269(5):672-84.
2002: Ana A Kitazono; Stephen J Kron
An essential function of yeast cyclin-dependent kinase Cdc28 maintains chromosome stability.
The Journal of biological chemistry 2002;277(50):48627-34.
2002: Allan J LeSage; Stephen J Kron
Design and implementation of algorithms for focus automation in digital imaging time-lapse microscopy.
Cytometry 2002;49(4):159-69.
2002: John Choy; Stephen J Kron
NuA4 subunit Yng2 function in intra-S-phase DNA damage response.
Molecular and cellular biology 2002;22(23):8215-25.
2002: Matthew G Vander Heiden; John Choy; David J VanderWeele; Jennifer L Brace; Marian H Harris; Daniel E Bauer; Bryan Prange; Stephen J Kron; Craig Thompson; Charles Rudin
Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism.
The Journal of biological chemistry 2002;277(47):44870-6.
2002: Sean P Palecek; Archita S Parikh; Joon H Huh; Stephen J Kron
Depression of Saccharomyces cerevisiae invasive growth on non-glucose carbon sources requires the Snf1 kinase.
Molecular microbiology 2002;45(2):453-69.
2002: Jonathan N Fitz Gerald; Jacqueline M Benjamin; Stephen J Kron
Robust G1 checkpoint arrest in budding yeast: dependence on DNA damage signaling and repair.
Journal of cell science 2002;115(Pt 8):1749-57.
2002: Sean P Palecek; Archita S Parikh; Stephen J Kron
Sensing, signalling and integrating physical processes during Saccharomyces cerevisiae invasive and filamentous growth.
Microbiology (Reading, England) 2002;148(Pt 4):893-907.
2002: Benjamin T Houseman; Joon H Huh; Stephen J Kron; Milan Mrksich
Peptide chips for the quantitative evaluation of protein kinase activity.
Nature biotechnology 2002;20(3):270-4.
2002: Ana A Kitazono; Brian T D Tobe; Helen Kalton; Noam Diamant; Stephen J Kron
Marker-fusion PCR for one-step mutagenesis of essential genes in yeast.
Yeast (Chichester, England) 2002;19(2):141-9.
2002: Stephen J Kron
Digital time-lapse microscopy of yeast cell growth.
Methods in enzymology 2002;351():3-15.
2001: D Rua; Brian T D Tobe; Stephen J Kron
Cell cycle control of yeast filamentous growth.
Current opinion in microbiology 2001;4(6):720-7.
2001: John Choy; Brian T D Tobe; Joon H Huh; Stephen J Kron
Yng2p-dependent NuA4 histone H4 acetylation activity is required for mitotic and meiotic progression.
The Journal of biological chemistry 2001;276(47):43653-62.
2001: S H Ahn; Brian T D Tobe; Jonathan N Fitz Gerald; S L Anderson; A Acurio; Stephen J Kron
Enhanced cell polarity in mutants of the budding yeast cyclin-dependent kinase Cdc28p.
Molecular biology of the cell 2001;12(11):3589-600.
2000: Sean P Palecek; Archita S Parikh; Stephen J Kron
Genetic analysis reveals that FLO11 upregulation and cell polarization independently regulate invasive growth in Saccharomyces cerevisiae.
Genetics 2000;156(3):1005-23.
2000: Marian H Harris; Matthew G Vander Heiden; Stephen J Kron; Craig Thompson
Role of oxidative phosphorylation in Bax toxicity.
Molecular and cellular biology 2000;20(10):3590-6.
1999: S H Ahn; A Acurio; Stephen J Kron
Regulation of G2/M progression by the STE mitogen-activated protein kinase pathway in budding yeast filamentous growth.
Molecular biology of the cell 1999;10(10):3301-16.
1997: Stephen J Kron
Filamentous growth in budding yeast.
Trends in microbiology 1997;5(11):450-4.