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Chanoch Kronman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Anatomy

Cell Line

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Physiology

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Amino Acid Sequence

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Co-Publications
Name
44
Shafferman, Avigdor
43
Velan, Baruch
27
Ordentlich, Arie
20
Barak, Dov
14
Ariel, Naomi
8
Segall, Yoffi
7
Kaplan, Dana
5
Chitlaru, Theodor
5
Cohen, Ofer
4
Cohen, Sara
4
Mendelson, Itai
3
Mizrahi, Dana
3
Lazar, Arie
3
Inbar, Itzhak
3
Barak, R

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Publications

TOP 3
Mazor Ohad; Cohen Ofer; Kronman Chanoch; Raveh Lily; Stein Dana; Ordentlich Arie; Shafferman Avigdor
Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase.
Shafferman Avigdor; Barak Dov; Stein Dana; Kronman Chanoch; Velan Baruch; Greig Nigel H; Ordentlich Arie
Flexibility versus "rigidity" of the functional architecture of AChE active center.
Cohen Ofer; Kronman Chanoch; Lazar Arie; Velan Baruch; Shafferman Avigdor
Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants.

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All Publications

2008: Mazor Ohad; Cohen Ofer; Kronman Chanoch; Raveh Lily; Stein Dana; Ordentlich Arie; Shafferman Avigdor
Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase.
Molecular pharmacology 2008;74(3):755-63.
2008: Shafferman Avigdor; Barak Dov; Stein Dana; Kronman Chanoch; Velan Baruch; Greig Nigel H; Ordentlich Arie
Flexibility versus "rigidity" of the functional architecture of AChE active center.
Chemico-biological interactions 2008;175(1-3):166-72.
2007: Cohen Ofer; Kronman Chanoch; Lazar Arie; Velan Baruch; Shafferman Avigdor
Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants.
The Journal of biological chemistry 2007;282(49):35491-501.
2007: Kronman Chanoch; Cohen Ofer; Raveh Lily; Mazor Ohad; Ordentlich Arie; Shafferman Avigdor
Polyethylene-glycol conjugated recombinant human acetylcholinesterase serves as an efficacious bioscavenger against soman intoxication.
Toxicology 2007;233(1-3):40-6.
2006: Cohen Ofer; Kronman Chanoch; Raveh Lily; Mazor Ohad; Ordentlich Arie; Shafferman Avigdor
Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds.
Molecular pharmacology 2006;70(3):1121-31.
2005: Barak Dov; Ordentlich Arie; Kaplan Dana; Kronman Chanoch; Velan Baruch; Shafferman Avigdor
Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents.
Chemico-biological interactions 2005;157-158():219-26.
2005: Kronman Chanoch; Cohen Ofer; Velan Baruch; Shafferman Avigdor
Host-regulated disposition of mammalian AChEs.
Chemico-biological interactions 2005;157-158():51-5.
2005: Ordentlich Arie; Barak Dov; Sod-Moriah Gali; Kaplan Dana; Mizrahi Dana; Segall Yoffi; Kronman Chanoch; Karton Yishai; Lazar Arie; Marcus Dino; Velan Baruch; Shafferman Avigdor
The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers.
Chemico-biological interactions 2005;157-158():191-8.
2005: Shafferman Avigdor; Barak Dov; Kaplan Dana; Ordentlich Arie; Kronman Chanoch; Velan Baruch
Functional requirements for the optimal catalytic configuration of the AChE active center.
Chemico-biological interactions 2005;157-158():123-31.
2005: Mendelson I; Gat O; Aloni-Grinstein R; Altboum Z; Inbar I; Kronman C; Bar-Haim E; Cohen S; Velan B; Shafferman A
Efficacious, nontoxigenic Bacillus anthracis spore vaccines based on strains expressing mutant variants of lethal toxin components.
Vaccine 2005;23(48-49):5688-97.
2004: Ordentlich Arie; Barak Dov; Sod-Moriah Gali; Kaplan Dana; Mizrahi Dana; Segall Yoffi; Kronman Chanoch; Karton Yishai; Lazar Arie; Marcus Dino; Velan Baruch; Shafferman Avigdor
Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE.
Biochemistry 2004;43(35):11255-65.
2004: Kaplan Dana; Barak Dov; Ordentlich Arie; Kronman Chanoch; Velan Baruch; Shafferman Avigdor
Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase?
Biochemistry 2004;43(11):3129-36.
2004: Cohen Ofer; Kronman Chanoch; Velan Baruch; Shafferman Avigdor
Amino acid domains control the circulatory residence time of primate acetylcholinesterases in rhesus macaques (Macaca mulatta).
The Biochemical journal 2004;378(Pt 1):117-28.
2003: Gat O; Inbar I; Aloni-Grinstein R; Zahavy E; Kronman C; Mendelson I; Cohen S; Velan B; Shafferman A
Use of a promoter trap system in Bacillus anthracis and Bacillus subtilis for the development of recombinant protective antigen-based vaccines.
Infection and immunity 2003;71(2):801-13.
2003: Grosfeld Haim; Cohen Sara; Bino Tamar; Flashner Yehuda; Ber Raphael; Mamroud Emanuelle; Kronman Chanoch; Shafferman Avigdor; Velan Baruch
Effective protective immunity to Yersinia pestis infection conferred by DNA vaccine coding for derivatives of the F1 capsular antigen.
Infection and immunity 2003;71(1):374-83.
2002: Chitlaru Theodor; Kronman Chanoch; Velan Baruch; Shafferman Avigdor
Overloading and removal of N-glycosylation targets on human acetylcholinesterase: effects on glycan composition and circulatory residence time.
The Biochemical journal 2002;363(Pt 3):619-31.
2001: Cohen O; Kronman C; Chitlaru T; Ordentlich A; Velan B; Shafferman A
Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity.
The Biochemical journal 2001;357(Pt 3):795-802.
2001: Kaplan D; Ordentlich A; Barak D; Ariel N; Kronman C; Velan B; Shafferman A
Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?
Biochemistry 2001;40(25):7433-45.
2001: Chitlaru T; Kronman C; Velan B; Shafferman A
Effect of human acetylcholinesterase subunit assembly on its circulatory residence.
The Biochemical journal 2001;354(Pt 3):613-25.
2000: Kryger G; Harel M; Giles K; Toker L; Velan B; Lazar A; Kronman C; Barak D; Ariel N; Shafferman A; Silman I; Sussman J L
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1385-94.
2000: Kronman C; Chitlaru T; Elhanany E; Velan B; Shafferman A
Hierarchy of post-translational modifications involved in the circulatory longevity of glycoproteins. Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesterase.
The Journal of biological chemistry 2000;275(38):29488-502.
2000: Cohen S; Mendelson I; Altboum Z; Kobiler D; Elhanany E; Bino T; Leitner M; Inbar I; Rosenberg H; Gozes Y; Barak R; Fisher M; Kronman C; Velan B; Shafferman A
Attenuated nontoxinogenic and nonencapsulated recombinant Bacillus anthracis spore vaccines protect against anthrax.
Infection and immunity 2000;68(8):4549-58.
2000: Barak D; Ordentlich A; Kaplan D; Barak R; Mizrahi D; Kronman C; Segall Y; Velan B; Shafferman A
Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase.
Biochemistry 2000;39(5):1156-61.
1999: Malany S; Baker N; Verweyst M; Medhekar R; Quinn D M; Velan B; Kronman C; Shafferman A
Theoretical and experimental investigations of electrostatic effects on acetylcholinesterase catalysis and inhibition.
Chemico-biological interactions 1999;119-120():99-110.
1999: Ordentlich A; Barak D; Kronman C; Benschop H P; De Jong L P; Ariel N; Barak R; Segall Y; Velan B; Shafferman A
Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers.
Biochemistry 1999;38(10):3055-66.
1998: Chitlaru T; Kronman C; Zeevi M; Kam M; Harel A; Ordentlich A; Velan B; Shafferman A
Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels.
The Biochemical journal 1998;336 ( Pt 3)():647-58.
1998: Mendelson I; Kronman C; Ariel N; Shafferman A; Velan B
Bovine acetylcholinesterase: cloning, expression and characterization.
The Biochemical journal 1998;334 ( Pt 1)():251-9.
1998: Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A
Functional characteristics of the oxyanion hole in human acetylcholinesterase.
The Journal of biological chemistry 1998;273(31):19509-17.
1996: Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A
The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors.
The Journal of biological chemistry 1996;271(20):11953-62.
1995: Barak D; Ordentlich A; Bromberg A; Kronman C; Marcus D; Lazar A; Ariel N; Velan B; Shafferman A
Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite.
Biochemistry 1995;34(47):15444-52.
1995: Kronman C; Velan B; Marcus D; Ordentlich A; Reuveny S; Shafferman A
Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation.
The Biochemical journal 1995;311 ( Pt 3)():959-67.
1995: Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A
Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase.
The Journal of biological chemistry 1995;270(5):2082-91.
1994: Kronman C; Ordentlich A; Barak D; Velan B; Shafferman A
The "back door" hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis.
The Journal of biological chemistry 1994;269(45):27819-22.
1994: Velan B; Kronman C; Flashner Y; Shafferman A
Reversal of signal-mediated cellular retention by subunit assembly of human acetylcholinesterase.
The Journal of biological chemistry 1994;269(36):22719-25.
1994: Shafferman A; Ordentlich A; Barak D; Kronman C; Ber R; Bino T; Ariel N; Osman R; Velan B
Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase.
The EMBO journal 1994;13(15):3448-55.
1994: Ashani Y; Grunwald J; Kronman C; Velan B; Shafferman A
Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.
Molecular pharmacology 1994;45(3):555-60.
1994: Barak D; Kronman C; Ordentlich A; Ariel N; Bromberg A; Marcus D; Lazar A; Velan B; Shafferman A
Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.
The Journal of biological chemistry 1994;269(9):6296-305.
1993: Velan B; Kronman C; Ordentlich A; Flashner Y; Leitner M; Cohen S; Shafferman A
N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis.
The Biochemical journal 1993;296 ( Pt 3)():649-56.
1993: Ordentlich A; Kronman C; Barak D; Stein D; Ariel N; Marcus D; Velan B; Shafferman A
Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center.
FEBS letters 1993;334(2):215-20.
1993: Ordentlich A; Barak D; Kronman C; Flashner Y; Leitner M; Segall Y; Ariel N; Cohen S; Velan B; Shafferman A
Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket.
The Journal of biological chemistry 1993;268(23):17083-95.
1993: Kerem A; Kronman C; Bar-Nun S; Shafferman A; Velan B
Interrelations between assembly and secretion of recombinant human acetylcholinesterase.
The Journal of biological chemistry 1993;268(1):180-4.
1993: Lazar A; Reuveny S; Kronman C; Velan B; Shafferman A
Evaluation of anchorage-dependent cell propagation systems for production of human acetylcholinesterase by recombinant 293 cells.
Cytotechnology 1993;13(2):115-23.
1992: Kronman C; Velan B; Gozes Y; Leitner M; Flashner Y; Lazar A; Marcus D; Sery T; Papier Y; Grosfeld H
Production and secretion of high levels of recombinant human acetylcholinesterase in cultured cell lines: microheterogeneity of the catalytic subunit.
Gene 1992;121(2):295-304.
1992: Shafferman A; Velan B; Ordentlich A; Kronman C; Grosfeld H; Leitner M; Flashner Y; Cohen S; Barak D; Ariel N
Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.
The EMBO journal 1992;11(10):3561-8.
1992: Shafferman A; Kronman C; Flashner Y; Leitner M; Grosfeld H; Ordentlich A; Gozes Y; Cohen S; Ariel N; Barak D
Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.
The Journal of biological chemistry 1992;267(25):17640-8.
1991: Velan B; Grosfeld H; Kronman C; Leitner M; Gozes Y; Lazar A; Flashner Y; Marcus D; Cohen S; Shafferman A
The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant.
The Journal of biological chemistry 1991;266(35):23977-84.
1991: Velan B; Kronman C; Grosfeld H; Leitner M; Gozes Y; Flashner Y; Sery T; Cohen S; Ben-Aziz R; Seidman S
Recombinant human acetylcholinesterase is secreted from transiently transfected 293 cells as a soluble globular enzyme.
Cellular and molecular neurobiology 1991;11(1):143-56.

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