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Paul Kroon

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Raquel Mateos; Gema Pereira-Caro; Beatriz Sarriá; James R Bacon; Roy Bongaerts; Laura Bravo; Paul A Kroon
Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells.
Elisa Boschetti; James R Bacon; Alessandra Bordoni; Felicity Meyer; Vitaliano Tugnoli; Paul A Kroon
Comparison between single-cell cultures and tissue cultures as model systems for evaluating the modulation of gene expression by food bioactives.
Luisa M Ostertag; Shikha Saha; Sharon Wood; Elena Cienfuegos-Jovellanos; Garry G Duthie; Graham Horgan; Paul A Kroon; Baukje de Roos
Flavan-3-ol-enriched dark chocolate and white chocolate improve acute measures of platelet function in a gender-specific way--a randomized-controlled human intervention trial.

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2013: Raquel Mateos; Gema Pereira-Caro; Beatriz Sarriá; James R Bacon; Roy Bongaerts; Laura Bravo; Paul A Kroon
Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells.
Journal of agricultural and food chemistry 2013;61(13):3264-9.
2013: Elisa Boschetti; James R Bacon; Alessandra Bordoni; Felicity Meyer; Vitaliano Tugnoli; Paul A Kroon
Comparison between single-cell cultures and tissue cultures as model systems for evaluating the modulation of gene expression by food bioactives.
International journal of food sciences and nutrition 2013;64(2):194-201.
2013: Luisa M Ostertag; Shikha Saha; Sharon Wood; Elena Cienfuegos-Jovellanos; Garry G Duthie; Graham Horgan; Paul A Kroon; Baukje de Roos
Flavan-3-ol-enriched dark chocolate and white chocolate improve acute measures of platelet function in a gender-specific way--a randomized-controlled human intervention trial.
Molecular nutrition & food research 2013;57(2):191-202.
2012: Shikha Saha; Birgit Teucher; David A Barrett; Wendy Hollands; Richard Mithen; Arjan Narbad; Paul W Needs; Catharine A Ortori; John T Rossiter; Paul A Kroon
Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli.
Molecular nutrition & food research 2012;56(12):1906-16.
2012: Federica Lodi; Paul W Needs; Sandra Tribolo; Mark S Winterbone; David A Hughes; Paul A Kroon
Human quercetin conjugated metabolites attenuate TNF-α-induced changes in vasomodulatory molecules in an HUASMCs/HUVECs co-culture model.
Planta medica 2012;78(14):1571-3.
2012: S Saha; Paul W Needs; L M Ostertag; Baukje de Roos; G G Duthie; W Hollands; Paul A Kroon
Human O-sulfated metabolites of (-)-epicatechin and methyl-(-)-epicatechin are poor substrates for commercial aryl-sulfatases: implications for studies concerned with quantifying epicatechin bioavailability.
Pharmacological research : the official journal of the Italian Pharmacological Society 2012;65(6):592-602.
2011: Salmin Al-Shalmani; Sunita Suri; David A Hughes; Paul A Kroon; Paul W Needs; Moira A Taylor; Sandra Tribolo; VG Wilson
Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery.
British journal of pharmacology 2011;162(7):1485-97.
2010: S Suri; X H Liu; S Rayment; D A Hughes; Paul A Kroon; P W Needs; Moira A Taylor; S Tribolo; VG Wilson
Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery.
British journal of pharmacology 2010;159(3):566-75.
2009: Colin D Kay; Paul A Kroon; Aedin Cassidy
The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products.
Molecular nutrition & food research 2009;53 Suppl 1():S92-101.
2009: Gary M Brett; Wendy Hollands; Paul W Needs; Birgit Teucher; Jack R Dainty; Barry D Davis; Jennifer S Brodbelt; Paul A Kroon
Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion.
The British journal of nutrition 2009;101(5):664-75.
2009: María Teresa García-Conesa; Sandra Tribolo; Sylvain Guyot; Francisco A Tomás-Barberán; Paul A Kroon
Oligomeric procyanidins inhibit cell migration and modulate the expression of migration and proliferation associated genes in human umbilical vascular endothelial cells.
Molecular nutrition & food research 2009;53(2):266-76.
2009: Mark S Winterbone; Sandra Tribolo; Paul W Needs; Paul A Kroon; David A Hughes
Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells.
Atherosclerosis 2009;202(2):431-8.
2008: R Pierini; Paul A Kroon; S Guyot; Ian Johnson; Nigel J Belshaw
The procyanidin-mediated induction of apoptosis and cell-cycle arrest in esophageal adenocarcinoma cells is not dependent on p21(Cip1/WAF1).
Cancer letters 2008;270(2):234-41.
2008: Wendy Hollands; Gary M Brett; Jack R Dainty; Birgit Teucher; Paul A Kroon
Urinary excretion of strawberry anthocyanins is dose dependent for physiological oral doses of fresh fruit.
Molecular nutrition & food research 2008;52(10):1097-105.
2008: Sunita Suri; Moira A Taylor; Anne Verity; Sandra Tribolo; Paul W Needs; Paul A Kroon; David A Hughes; Vincent G Wilson
A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro.
Biochemical pharmacology 2008;76(5):645-53.
2008: Wai Mun Loke; Julie M Proudfoot; Scott Stewart; Allan J McKinley; Paul W Needs; Paul A Kroon; Jonathan M Hodgson; Kevin D Croft
Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity.
Biochemical pharmacology 2008;75(5):1045-53.
2008: Sandra Tribolo; Federica Lodi; Carol Connor; Sunita Suri; Vincent G Wilson; Moira A Taylor; Paul W Needs; Paul A Kroon; David A Hughes
Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells.
Atherosclerosis 2008;197(1):50-6.
2007: Gary Williamson; Isabelle Aeberli; Laurence Miguet; Ziding Zhang; M-Belen Sanchez; Vanessa Crespy; Denis Barron; Paul W Needs; Paul A Kroon; Hristos Glavinas; Peter Krajcsi; Martin G Grigorov
Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2).
Drug metabolism and disposition: the biological fate of chemicals 2007;35(8):1262-8.
2007: Sandra Tribolo; Jean-Guy Berrin; Paul A Kroon; Mirjam Czjzek; Nathalie Juge
The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase.
Journal of molecular biology 2007;370(5):964-75.
2006: Barry D Davis; Paul W Needs; Paul A Kroon; Jennifer S Brodbelt
Identification of isomeric flavonoid glucuronides in urine and plasma by metal complexation and LC-ESI-MS/MS.
Journal of mass spectrometry : JMS 2006;41(7):911-20.
2006: Richard N Bennett; Eduardo A S Rosa; Fred A Mellon; Paul A Kroon
Ontogenic profiling of glucosinolates, flavonoids, and other secondary metabolites in Eruca sativa (salad rocket), Diplotaxis erucoides (wall rocket), Diplotaxis tenuifolia (wild rocket), and Bunias orientalis (Turkish rocket).
Journal of agricultural and food chemistry 2006;54(11):4005-15.
2005: Elizabeth L Adams; Paul A Kroon; Gary Williamson; Victor J Morris
AFM studies of water-soluble wheat arabinoxylans--effects of esterase treatment.
Carbohydrate research 2005;340(11):1841-5.
2004: A Patrick Gunning; Andrew R Kirby; Alan R Mackie; Paul A Kroon; Gary Williamson; Victor J Morris
Watching molecular processes with the atomic force microscope: dynamics of polymer adsorption and desorption at the single molecule level.
Journal of microscopy 2004;216(Pt 1):52-6.
2004: Richard N Bennett; Fred A Mellon; Eduardo A S Rosa; Lionel Perkins; Paul A Kroon
Profiling glucosinolates, flavonoids, alkaloids, and other secondary metabolites in tissues of Azima tetracantha L. (Salvadoraceae).
Journal of agricultural and food chemistry 2004;52(19):5856-62.
2004: Vanda Svehliková; Richard N Bennett; Fred A Mellon; Paul W Needs; Sonia Piacente; Paul A Kroon; Yongping Bao
Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert).
Phytochemistry 2004;65(16):2323-32.
2004: Paul A Kroon; Michael N Clifford; Alan Crozier; Andrea J Day; Jennifer L Donovan; Claudine Manach; Gary Williamson
How should we assess the effects of exposure to dietary polyphenols in vitro?
The American journal of clinical nutrition 2004;80(1):15-21.
2004: M Susan DuPont; Andrea J Day; Richard N Bennett; Fred A Mellon; Paul A Kroon
Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans.
European journal of clinical nutrition 2004;58(6):947-54.
2004: Maria-Teresa Garcia-Conesa; Valerie F Crepin; Andrew J Goldson; Gary Williamson; Nicola Cummings; Ian F Connerton; Craig B Faulds; Paul A Kroon
The feruloyl esterase system of Talaromyces stipitatus: production of three discrete feruloyl esterases, including a novel enzyme, TsFaeC, with a broad substrate specificity.
Journal of biotechnology 2004;108(3):227-41.
2004: Elizabeth L Adams; Paul A Kroon; Gary Williamson; Harry J Gilbert; Victor J Morris
Inactivated enzymes as probes of the structure of arabinoxylans as observed by atomic force microscopy.
Carbohydrate research 2004;339(3):579-90.
2004: Hans Goesaert; Giles Elliott; Paul A Kroon; Kurt Gebruers; Christophe M Courtin; Johan Robben; Jan A Delcour; Nathalie Juge
Occurrence of proteinaceous endoxylanase inhibitors in cereals.
Biochimica et biophysica acta 2004;1696(2):193-202.
2004: Richard N Bennett; Fred A Mellon; Paul A Kroon
Screening crucifer seeds as sources of specific intact glucosinolates using ion-pair high-performance liquid chromatography negative ion electrospray mass spectrometry.
Journal of agricultural and food chemistry 2004;52(3):428-38.
2003: Sandra M Kern; Richard N Bennett; Paul W Needs; Fred A Mellon; Paul A Kroon; Maria-Teresa Garcia-Conesa
Characterization of metabolites of hydroxycinnamates in the in vitro model of human small intestinal epithelium caco-2 cells.
Journal of agricultural and food chemistry 2003;51(27):7884-91.
2003: Roger Corder; Alan Crozier; Paul A Kroon
Drinking your health? It's too early to say.
Nature 2003;426(6963):119.
2003: Sandra M Kern; Richard N Bennett; Fred A Mellon; Paul A Kroon; Maria-Teresa Garcia-Conesa
Absorption of hydroxycinnamates in humans after high-bran cereal consumption.
Journal of agricultural and food chemistry 2003;51(20):6050-5.
2003: Jean-Guy Berrin; Mirjam Czjzek; Paul A Kroon; W Russell McLauchlan; Antoine Puigserver; Gary Williamson; Nathalie Juge
Substrate (aglycone) specificity of human cytosolic beta-glucosidase.
The Biochemical journal 2003;373(Pt 1):41-8.
2003: Richard N Bennett; Fred A Mellon; Nikolaus Foidl; John H Pratt; M Susan DuPont; Lionel Perkins; Paul A Kroon
Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (horseradish tree) and Moringa stenopetala L.
Journal of agricultural and food chemistry 2003;51(12):3546-53.
2003: Niclas Petri; Christer Tannergren; Birgit Holst; Fred A Mellon; Yongping Bao; Geoff W Plumb; James R Bacon; Karen A O'Leary; Paul A Kroon; Lars Knutson; Patrik Forsell; Thomas Eriksson; Hans Lennernas; Gary Williamson
Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(6):805-13.
2003: Elizabeth L Adams; Paul A Kroon; Gary Williamson; Victor J Morris
Characterisation of heterogeneous arabinoxylans by direct imaging of individual molecules by atomic force microscopy.
Carbohydrate research 2003;338(8):771-80.
2003: Marcos J C Alcocer; Caroline Furniss; Paul A Kroon; M Campbell; David B Archer
Comparison of modular and non-modular xylanases as carrier proteins for the efficient secretion of heterologous proteins from Penicillium funiculosum.
Applied microbiology and biotechnology 2003;60(6):726-32.
2003: Kitti Németh; Geoff W Plumb; Jean-Guy Berrin; Nathalie Juge; Ralf Jacob; Hassan Y Naim; Gary Williamson; Dallas M Swallow; Paul A Kroon
Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.
European journal of nutrition 2003;42(1):29-42.
2002: Caroline Furniss; Nigel J Belshaw; Marcos J C Alcocer; Gary Williamson; Giles Elliott; Kurt Gebruers; Nigel P Haigh; Neville M Fish; Paul A Kroon
A family 11 xylanase from Penicillium funiculosum is strongly inhibited by three wheat xylanase inhibitors.
Biochimica et biophysica acta 2002;1598(1-2):24-9.
2002: Giles Elliott; Richard K Hughes; Nathalie Juge; Paul A Kroon; Gary Williamson
Functional identification of the cDNA coding for a wheat endo-1,4-beta-D-xylanase inhibitor.
FEBS letters 2002;519(1-3):66-70.
2002: Jean-Guy Berrin; W Russell McLauchlan; Paul W Needs; Gary Williamson; Antoine Puigserver; Paul A Kroon; Nathalie Juge
Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides.
European journal of biochemistry / FEBS 2002;269(1):249-58.
2001: MF Andreasen; Paul A Kroon; Gary Williamson; Maria-Teresa Garcia-Conesa
Esterase activity able to hydrolyze dietary antioxidant hydroxycinnamates is distributed along the intestine of mammals.
Journal of agricultural and food chemistry 2001;49(11):5679-84.
2001: MF Andreasen; Paul A Kroon; Gary Williamson; Maria-Teresa Garcia-Conesa
Intestinal release and uptake of phenolic antioxidant diferulic acids.
Free radical biology & medicine 2001;31(3):304-14.
2000: Paul A Kroon; Gary Williamson; Neville M Fish; David B Archer; Nigel J Belshaw
A modular esterase from Penicillium funiculosum which releases ferulic acid from plant cell walls and binds crystalline cellulose contains a carbohydrate binding module.
European journal of biochemistry / FEBS 2000;267(23):6740-52.
2000: Andrea J Day; F J Cañada; J C Díaz; Paul A Kroon; R Mclauchlan; Craig B Faulds; Geoff W Plumb; Michael R A Morgan; Gary Williamson
Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase.
FEBS letters 2000;468(2-3):166-70.
1999: Maria-Teresa Garcia-Conesa; Paul A Kroon; John Ralph; Fred A Mellon; Ian J Colquhoun; Luc Saulnier; Jean-François Thibault; Gary Williamson
A cinnamoyl esterase from Aspergillus niger can break plant cell wall cross-links without release of free diferulic acids.
European journal of biochemistry / FEBS 1999;266(2):644-52.
1999: N Lambert; Paul A Kroon; Craig B Faulds; Geoff W Plumb; W Russell McLauchlan; Andrea J Day; Gary Williamson
Purification of cytosolic beta-glucosidase from pig liver and its reactivity towards flavonoid glycosides.
Biochimica et biophysica acta 1999;1435(1-2):110-6.
1998: Gary Williamson; Paul A Kroon; Craig B Faulds
Hairy plant polysaccharides: a close shave with microbial esterases.
Microbiology (Reading, England) 1998;144 ( Pt 8)():2011-23.
1998: Maria-Teresa Garcia-Conesa; Paul A Kroon; Gary Williamson
Enzymic hydrolysis of diferulates from wheat bran cell walls.
Biochemical Society transactions 1998;26(2):S168.
1998: Paul A Kroon; Gary Williamson
Three distinct ferulic acid esterases produced by Aspergillus niger have specificities for different phenolic-sugar linkages in plant cell walls.
Biochemical Society transactions 1998;26(2):S167.
1998: Geoff W Plumb; Maria-Teresa Garcia-Conesa; Paul A Kroon; G Wallace; Gary Williamson
Properties of ferulate dimers from plant cell walls.
Biochemical Society transactions 1998;26(2):S166.
1998: Gary Williamson; Craig B Faulds; Paul A Kroon
Specificity of ferulic acid (feruloyl) esterases.
Biochemical Society transactions 1998;26(2):205-9.
1997: Craig B Faulds; R P deVries; Paul A Kroon; J Visser; Gary Williamson
Influence of ferulic acid on the production of feruloyl esterases by Aspergillus niger.
FEMS microbiology letters 1997;157(2):239-44.
1997: Ronald P de Vries; B Michelsen; CH Poulsen; Paul A Kroon; R H van den Heuvel; Craig B Faulds; Gary Williamson; J P van den Hombergh; Jaap Visser
The faeA genes from Aspergillus niger and Aspergillus tubingensis encode ferulic acid esterases involved in degradation of complex cell wall polysaccharides.
Applied and environmental microbiology 1997;63(12):4638-44.
1997: Paul A Kroon; Craig B Faulds; C Brézillon; Gary Williamson
Methyl phenylalkanoates as substrates to probe the active sites of esterases.
European journal of biochemistry / FEBS 1997;248(1):245-51.
1997: Begoña Bartolomé; Craig B Faulds; Paul A Kroon; Keith W Waldron; Harry J Gilbert; GP Hazlewood; Gary Williamson
An Aspergillus niger esterase (ferulic acid esterase III) and a recombinant Pseudomonas fluorescens subsp. cellulosa esterase (Xy1D) release a 5-5' ferulic dehydrodimer (diferulic acid) from barley and wheat cell walls.
Applied and environmental microbiology 1997;63(1):208-12.
1996: Paul A Kroon; Craig B Faulds; Peter Ryden; Gary Williamson
Solubilisation of ferulic acid from plant cell wall materials in a model human gut system.
Biochemical Society transactions 1996;24(3):384S.
1996: Paul A Kroon; Gary Williamson
Release of ferulic acid from sugar-beet pulp by using arabinanase, arabinofuranosidase and an esterase from Aspergillus niger.
Biotechnology and applied biochemistry 1996;23 ( Pt 3)():263-7.
1996: Paul A Kroon; Craig B Faulds; Gary Williamson
Purification and characterization of a novel esterase induced by growth of Aspergillus niger on sugar-beet pulp.
Biotechnology and applied biochemistry 1996;23 ( Pt 3)():255-62.