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James Krueger

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Michelle A Lowes; David A Martin; Chris B Russell; Jennifer E Towne; James G Krueger
The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses.
Milène Kennedy Crispin; Inna Cueto; Judilyn Fuentes-Duculan; Patricia Gilleaudeau; Nicholas Gulati; Leanne M Johnson-Huang; Tim Lentini; Michelle A Lowes; Mayte Suárez-Fariñas; Mary Sullivan-Whalen; James G Krueger
Gene profiling of narrowband UVB-induced skin injury defines cellular and molecular innate immune responses.
Daniel A Belkin; Israel Coats; Diane Felsen; Juana Gonzalez; James G Krueger; Hiroshi Mitsui; Kejal R Shah; Mayte Suàrez-Fariñas; Claire Q F Wang; Shali Zhang; John A Carucci
CD200 upregulation in vascular endothelium surrounding cutaneous squamous cell carcinoma.

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All Publications

2013: Michelle A Lowes; David A Martin; Chris B Russell; Jennifer E Towne; James G Krueger
The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses.
Trends in immunology 2013;34(4):174-81.
2013: Milène Kennedy Crispin; Inna Cueto; Judilyn Fuentes-Duculan; Patricia Gilleaudeau; Nicholas Gulati; Leanne M Johnson-Huang; Tim Lentini; Michelle A Lowes; Mayte Suárez-Fariñas; Mary Sullivan-Whalen; James G Krueger
Gene profiling of narrowband UVB-induced skin injury defines cellular and molecular innate immune responses.
The Journal of investigative dermatology 2013;133(3):692-701.
2013: Daniel A Belkin; Israel Coats; Diane Felsen; Juana Gonzalez; James G Krueger; Hiroshi Mitsui; Kejal R Shah; Mayte Suàrez-Fariñas; Claire Q F Wang; Shali Zhang; John A Carucci
CD200 upregulation in vascular endothelium surrounding cutaneous squamous cell carcinoma.
JAMA dermatology (Chicago, Ill.) 2013;149(2):178-86.
2013: Mayte Suárez-Fariñas; Irma Cardinale; Julia K Gittler; James G Krueger; Avner Shemer; Emma Guttman-Yassky
Residual genomic signature of atopic dermatitis despite clinical resolution with narrow-band UVB.
The Journal of allergy and clinical immunology 2013;131(2):577-9.
2013: Shali Zhang; Diane Felsen; Judilyn Fuentes-Duculan; Hideki Fujita; Juana Gonzalez; James G Krueger; Hiroshi Mitsui; Julia S Pettersen; Mayte Suárez-Fariñas; Claire Q F Wang; Valerie R Yanofsky; John A Carucci
Increased Tc22 and Treg/CD8 Ratio Contribute to Aggressive Growth of Transplant Associated Squamous Cell Carcinoma.
PloS one 2013;8(5):e62154.
2012: James G Krueger
Hiding under the skin: A welcome surprise in psoriasis.
Nature medicine 2012;18(12):1750-1.
2012: Mayte Suárez-Fariñas; Katherine Li; Carrie Brodmerkel; Judilyn Fuentes-Duculan; Karen Hayden; James G Krueger
Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis.
The Journal of investigative dermatology 2012;132(11):2552-64.
2012: Leanne M Johnson-Huang; Michelle A Lowes; James G Krueger
Putting together the psoriasis puzzle: an update on developing targeted therapies.
Disease models & mechanisms 2012;5(4):423-33.
2012: James G Krueger; Juliet McColm; Krista M Phipps; Mayte Suárez-Fariñas; Traci White; Subhashis Banerjee; Gregory S Cameron; Inna Cueto; Scott Fretzin; Patrick A Haslett; Artemis Katcherian; Robert W Hoffman
IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis.
The Journal of allergy and clinical immunology 2012;130(1):145-54.e9.
2012: Hideki Fujita; Juana Gonzalez; James G Krueger; Hiroshi Mitsui; Mayte Suárez-Fariñas; Shali Zhang; Mark J Bluth; Diane Felsen; John A Carucci
Langerhans cells from human cutaneous squamous cell carcinoma induce strong type 1 immunity.
The Journal of investigative dermatology 2012;132(6):1645-55.
2012: Hiroshi Mitsui; Mayte Suárez-Fariñas; Natasha Levenkova; Daniel A Belkin; Israel Coats; Judilyn Fuentes-Duculan; Hideki Fujita; James G Krueger
Combined use of laser capture microdissection and cDNA microarray analysis identifies locally expressed disease-related genes in focal regions of psoriasis vulgaris skin lesions.
The Journal of investigative dermatology 2012;132(6):1615-26.
2012: Leanne M Johnson-Huang; James G Krueger; Tim Lentini; Inna Cueto; Judilyn Fuentes-Duculan; Patricia Gilleaudeau; Asifa S Haider; Katherine C Pierson; Mayte Suárez-Fariñas; Mary Sullivan-Whalen; Michelle A Lowes
A single intradermal injection of IFN-γ induces an inflammatory state in both non-lesional psoriatic and healthy skin.
The Journal of investigative dermatology 2012;132(4):1177-87.
2012: Kim A Papp; Chris B Russell; Elizabeth H Z Thompson; Girish Aras; Gregory Kricorian; James G Krueger; Craig Leonardi; Juan Li; Alan Menter; Jean-Paul Ortonne; Scott Baumgartner
Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis.
The New England journal of medicine 2012;366(13):1181-9.
2012: Suyan Tian; Carrie Brodmerkel; Ali Jabbari; James G Krueger; Katherine Li; Michelle A Lowes; Mayte Suárez-Fariñas
Meta-analysis derived (MAD) transcriptome of psoriasis defines the "core" pathogenesis of disease.
PloS one 2012;7(9):e44274.
2012: Yumiko Wada; Noriaki Tatsuta; James Barsoum; Irma Cardinale; John Chu; Alice B Gottlieb; Eric Jacobson; Aaron B Kantor; Artemis Khatcherian; James G Krueger
Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.
PloS one 2012;7(4):e35069.
2012: Leanne M Johnson-Huang; Artemis Khatcherian; Toyoko Kikuchi; James G Krueger; Tim Lentini; Cara A Pensabene; Katherine C Pierson; Kejal R Shah; Mayte Suárez-Fariñas; Mary Sullivan-Whalen; Inna Cueto; Patricia Gilleaudeau; Luke A Hyder; Michelle A Lowes
Post-therapeutic relapse of psoriasis after CD11a blockade is associated with T cells and inflammatory myeloid DCs.
PloS one 2012;7(2):e30308.
2011: Suzanne Tintle; Anne Bowcock; Irma Cardinale; Andrea Chiricozzi; Shenghui Duan; Hideki Fujita; Patricia Gilleaudeau; Leanne Johnson-Huang; James G Krueger; Avner Shemer; Mayte Suárez-Fariñas; Mary Sullivan-Whalen; Emma Guttman-Yassky
Reversal of atopic dermatitis with narrow-band UVB phototherapy and biomarkers for therapeutic response.
The Journal of allergy and clinical immunology 2011;128(3):583-93.e1-4.
2011: Hideki Fujita; Irma Cardinale; John A Carucci; Judilyn Fuentes-Duculan; Leanne M Johnson-Huang; James G Krueger; Inna Novitskaya; Avner Shemer; Mayte Suárez-Fariñas; Suzanne Tintle; Emma Guttman-Yassky
Lesional dendritic cells in patients with chronic atopic dermatitis and psoriasis exhibit parallel ability to activate T-cell subsets.
The Journal of allergy and clinical immunology 2011;128(3):574-82.e1-12.
2011: Emma Guttman-Yassky; Kristine E Nograles; James G Krueger
Contrasting pathogenesis of atopic dermatitis and psoriasis--part II: immune cell subsets and therapeutic concepts.
The Journal of allergy and clinical immunology 2011;127(6):1420-32.
2011: Julia S Pettersen; Judilyn Fuentes-Duculan; Mayte Suárez-Fariñas; Katherine C Pierson; Alexander Pitts-Kiefer; Linda Fan; Daniel A Belkin; Claire Q F Wang; Shivaprasad Bhuvanendran; Leanne M Johnson-Huang; Mark J Bluth; James G Krueger; Michelle A Lowes; John A Carucci
Tumor-associated macrophages in the cutaneous SCC microenvironment are heterogeneously activated.
The Journal of investigative dermatology 2011;131(6):1322-30.
2011: Emma Guttman-Yassky; Kristine E Nograles; James G Krueger
Contrasting pathogenesis of atopic dermatitis and psoriasis--part I: clinical and pathologic concepts.
The Journal of allergy and clinical immunology 2011;127(5):1110-8.
2011: Mayte Suárez-Fariñas; Suzanne J Tintle; Avner Shemer; Andrea Chiricozzi; Kristine Nograles; Irma Cardinale; Shenghui Duan; Anne M Bowcock; James G Krueger; Emma Guttman-Yassky
Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities.
The Journal of allergy and clinical immunology 2011;127(4):954-64.e1-4.
2011: Mina Pastagia; Chad Euler; Peter Chahales; Judilyn Fuentes-Duculan; James G Krueger; Vincent Fischetti
A novel chimeric lysin shows superiority to mupirocin for skin decolonization of methicillin-resistant and -sensitive Staphylococcus aureus strains.
Antimicrobial agents and chemotherapy 2011;55(2):738-44.
2011: Mayte Suárez-Fariñas; Judilyn Fuentes-Duculan; Michelle A Lowes; James G Krueger
Resolved psoriasis lesions retain expression of a subset of disease-related genes.
The Journal of investigative dermatology 2011;131(2):391-400.
2011: Knut M Wittkowski; Jennifer Belasco; Alice Gottlieb; John Gray; Liz Horn; Gerald G Krueger; James G Krueger; Craig Leonardi; Alan Menter; Razieh Soltani-Arabshahi; Paul W Tebbey
Clinical symptoms of skin, nails, and joints manifest independently in patients with concomitant psoriasis and psoriatic arthritis.
PloS one 2011;6(6):e20279.
2011: Claire Q F Wang; Andres E Cruz-Inigo; Judilyn Fuentes-Duculan; Dariush Moussai; Nicholas Gulati; Mary Sullivan-Whalen; Patricia Gilleaudeau; Jules A Cohen; James G Krueger
Th17 cells and activated dendritic cells are increased in vitiligo lesions.
PloS one 2011;6(4):e18907.
2011: Dariush Moussai; Hiroshi Mitsui; Julia S Pettersen; Katherine C Pierson; Kejal R Shah; Mayte Suárez-Fariñas; Irma Cardinale; Mark J Bluth; James G Krueger; John A Carucci
The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C.
The Journal of investigative dermatology 2011;131(1):229-36.
2010: Leanne M Johnson-Huang; Mayte Suárez-Fariñas; Mary Sullivan-Whalen; Patricia Gilleaudeau; James G Krueger; Michelle A Lowes
Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques.
The Journal of investigative dermatology 2010;130(11):2654-63.
2010: Judilyn Fuentes-Duculan; Mayte Suárez-Fariñas; Lisa C Zaba; Kristine E Nograles; Katherine C Pierson; Hiroshi Mitsui; Cara A Pensabene; Julia Kzhyshkowska; James G Krueger; Michelle A Lowes
A subpopulation of CD163-positive macrophages is classically activated in psoriasis.
The Journal of investigative dermatology 2010;130(10):2412-22.
2010: Benjamin L Judson; Akira Miyaki; Vikram D Kekatpure; Baoheng Du; Patricia Gilleaudeau; Mary Sullivan-Whalen; Arash Mohebati; Sudhir Nair; Jay O Boyle; Richard D Granstein; Kotha Subbaramaiah; James G Krueger; Andrew J Dannenberg
UV radiation inhibits 15-hydroxyprostaglandin dehydrogenase levels in human skin: evidence of transcriptional suppression.
Cancer prevention research (Philadelphia, Pa.) 2010;3(9):1104-11.
2010: Emma Guttman-Yassky; Catalin Mita; Maja De Jonge; Lesley Matthews; Sean McCarthy; Kenneth K Iwata; Jaap Verweij; Eric K Rowinsky; James G Krueger
Characterisation of the cutaneous pathology in non-small cell lung cancer (NSCLC) patients treated with the EGFR tyrosine kinase inhibitor erlotinib.
European journal of cancer (Oxford, England : 1990) 2010;46(11):2010-9.
2010: Batya Davidovici; Naveed Sattar; Jörg C Prinz; Prinz C Jörg; Luis Puig; Paul Emery; Jonathan N Barker; Peter van de Kerkhof; Mona Ståhle; Frank O Nestle; Giampiero Girolomoni; James G Krueger
Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions.
The Journal of investigative dermatology 2010;130(7):1785-96.
2010: Lisa C Zaba; Judilyn Fuentes-Duculan; Narat John Eungdamrong; Leanne M Johnson-Huang; Kristine E Nograles; Traci R White; Katherine C Pierson; Tim Lentini; Mayte Suárez-Fariñas; Michelle A Lowes; James G Krueger
Identification of TNF-related apoptosis-inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis.
The Journal of allergy and clinical immunology 2010;125(6):1261-1268.e9.
2010: Kristine E Nograles; Batya Davidovici; James G Krueger
New insights in the immunologic basis of psoriasis.
Seminars in cutaneous medicine and surgery 2010;29(1):3-9.
2010: Kristine E Nograles; Mayte Suárez-Fariñas; Avner Shemer; Judilyn Fuentes-Duculan; Andrea Chiricozzi; Irma Cardinale; Lisa C Zaba; Toyoko Kikuchi; Michal Ramon; Reuven Bergman; James G Krueger; Emma Guttman-Yassky
Atopic dermatitis keratinocytes exhibit normal T(H)17 cytokine responses.
The Journal of allergy and clinical immunology 2010;125(3):744-6, 746.e1-746.e2.
2010: Mayte Suárez-Fariñas; Michelle A Lowes; Lisa C Zaba; James G Krueger
Evaluation of the psoriasis transcriptome across different studies by gene set enrichment analysis (GSEA).
PloS one 2010;5(4):e10247.
2010: Batya B Davidovici; Mary M Sullivan-Whalen; Patricia Gilleaudeau; James G Krueger
Differing effect of systemic anti psoriasis therapies on platelet physiology--a case report and review of literature.
BMC dermatology 2010;10():2.
2010: Mayte Suárez-Fariñas; Kejal R Shah; Asifa S Haider; James G Krueger; Michelle A Lowes
Personalized medicine in psoriasis: developing a genomic classifier to predict histological response to Alefacept.
BMC dermatology 2010;10():1.
2009: Hideki Fujita; Kristine E Nograles; Toyoko Kikuchi; Juana Gonzalez; John A Carucci; James G Krueger
Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(51):21795-800.
2009: Emma Guttman-Yassky; Mayte Suárez-Fariñas; Andrea Chiricozzi; Kristine E Nograles; Avner Shemer; Judilyn Fuentes-Duculan; Irma Cardinale; Peng Lin; Reuven Bergman; Anne M Bowcock; James G Krueger
Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis.
The Journal of allergy and clinical immunology 2009;124(6):1235-1244.e58.
2009: Lisa C Zaba; Mayte Suárez-Fariñas; Judilyn Fuentes-Duculan; Kristine E Nograles; Emma Guttman-Yassky; Irma Cardinale; Michelle A Lowes; James G Krueger
Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes.
The Journal of allergy and clinical immunology 2009;124(5):1022-10.e1-395.
2009: Mark J Bluth; Lisa C Zaba; Dariush Moussai; Mayte Suárez-Fariñas; Helen Kaporis; Linda Fan; Katherine C Pierson; Traci R White; Alexander Pitts-Kiefer; Judilyn Fuentes-Duculan; Emma Guttman-Yassky; James G Krueger; Michelle A Lowes; John A Carucci
Myeloid dendritic cells from human cutaneous squamous cell carcinoma are poor stimulators of T-cell proliferation.
The Journal of investigative dermatology 2009;129(10):2451-62.
2009: Kristine E Nograles; Lisa C Zaba; Avner Shemer; Judilyn Fuentes-Duculan; Irma Cardinale; Toyoko Kikuchi; Michal Ramon; Reuven Bergman; James G Krueger; Emma Guttman-Yassky
IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells.
The Journal of allergy and clinical immunology 2009;123(6):1244-52.e2.
2009: Leanne M Johnson-Huang; N Scott McNutt; James G Krueger; Michelle A Lowes
Cytokine-producing dendritic cells in the pathogenesis of inflammatory skin diseases.
Journal of clinical immunology 2009;29(3):247-56.
2009: Lisa C Zaba; James G Krueger; Michelle A Lowes
Resident and "inflammatory" dendritic cells in human skin.
The Journal of investigative dermatology 2009;129(2):302-8.
2008: Emma Guttman-Yassky; Michelle A Lowes; Judilyn Fuentes-Duculan; Lisa C Zaba; Irma Cardinale; Kristine E Nograles; Artemis Khatcherian; Inna Novitskaya; John A Carucci; Reuven Bergman; James G Krueger
Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7420-7.
2008: K E Nograles; L C Zaba; Emma Guttman-Yassky; Judilyn Fuentes-Duculan; Mayte Suárez-Fariñas; Irma Cardinale; Artemis Khatcherian; J Gonzalez; K C Pierson; T R White; C Pensabene; I Coats; Inna Novitskaya; Michelle A Lowes; James G Krueger
Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways.
The British journal of dermatology 2008;159(5):1092-102.
2008: James G Krueger; Hans D Ochs; Piyush Patel; Ellen Gilkerson; Emma Guttman-Yassky; Wolfgang Dummer
Effect of therapeutic integrin (CD11a) blockade with efalizumab on immune responses to model antigens in humans: results of a randomized, single blind study.
The Journal of investigative dermatology 2008;128(11):2615-24.
2008: Kim A Papp; Philippe Fonjallaz; Florence Casset-Semanaz; James G Krueger; Knut M Wittkowski
Analytical approaches to reporting long-term clinical trial data.
Current medical research and opinion 2008;24(7):2001-8.
2008: Emma Guttman-Yassky; Yulia Vugmeyster; Michelle A Lowes; Francesca Chamian; Toyoko Kikuchi; Mark Kagen; Patricia Gilleaudeau; Edmund Lee; Brisdell Hunte; Kathy Howell; Wolfgang Dummer; Sarah C Bodary; James G Krueger
Blockade of CD11a by efalizumab in psoriasis patients induces a unique state of T-cell hyporesponsiveness.
The Journal of investigative dermatology 2008;128(5):1182-91.
2008: Michelle A Lowes; Toyoko Kikuchi; Judilyn Fuentes-Duculan; Irma Cardinale; Lisa C Zaba; Asifa S Haider; Edward P Bowman; James G Krueger
Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells.
The Journal of investigative dermatology 2008;128(5):1207-11.
2008: Asifa S Haider; Jules Cohen; Ji Fei; Lisa C Zaba; Irma Cardinale; Kikuchi Toyoko; Jurg Ott; James G Krueger
Insights into gene modulation by therapeutic TNF and IFNgamma antibodies: TNF regulates IFNgamma production by T cells and TNF-regulated genes linked to psoriasis transcriptome.
The Journal of investigative dermatology 2008;128(3):655-66.
2008: Asifa S Haider; Michelle A Lowes; Mayte Suàrez-Fariñas; Lisa C Zaba; Irma Cardinale; Miroslav Blumenberg; James G Krueger
Cellular genomic maps help dissect pathology in human skin disease.
The Journal of investigative dermatology 2008;128(3):606-15.
2008: Asifa S Haider; Michelle A Lowes; Mayte Suárez-Fariñas; Lisa C Zaba; Irma Cardinale; Artemis Khatcherian; Inna Novitskaya; Knut M Wittkowski; James G Krueger
Identification of cellular pathways of "type 1," Th17 T cells, and TNF- and inducible nitric oxide synthase-producing dendritic cells in autoimmune inflammation through pharmacogenomic study of cyclosporine A in psoriasis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1913-20.
2007: Lisa C Zaba; Irma Cardinale; Patricia Gilleaudeau; Mary Sullivan-Whalen; Mayte Suárez-Fariñas; Mayte Suárez Fariñas; Judilyn Fuentes-Duculan; Inna Novitskaya; Artemis Khatcherian; Mark J Bluth; Michelle A Lowes; James G Krueger
Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses.
The Journal of experimental medicine 2007;204(13):3183-94.
2007: Emma Guttman-Yassky; James G Krueger
Psoriasis: evolution of pathogenic concepts and new therapies through phases of translational research.
The British journal of dermatology 2007;157(6):1103-15.
2007: Helen G Kaporis; Emma Guttman-Yassky; Michelle A Lowes; Asifa S Haider; Judilyn Fuentes-Duculan; Kamruz Darabi; Julia Whynot-Ertelt; Artemis Khatcherian; Irma Cardinale; Inna Novitskaya; James G Krueger; John A Carucci
Human basal cell carcinoma is associated with Foxp3+ T cells in a Th2 dominant microenvironment.
The Journal of investigative dermatology 2007;127(10):2391-8.
2007: Lisa C Zaba; Judilyn Fuentes-Duculan; Ralph M Steinman; James G Krueger; Michelle A Lowes
Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages.
The Journal of clinical investigation 2007;117(9):2517-25.
2007: Asifa S Haider; Michelle A Lowes; Humphrey Gardner; Raj Bandaru; Kamruz Darabi; Francesca Chamian; Toyoko Kikuchi; Patricia Gilleaudeau; Mary S Whalen; Irma Cardinale; Inna Novitskaya; James G Krueger
Novel insight into the agonistic mechanism of alefacept in vivo: differentially expressed genes may serve as biomarkers of response in psoriasis patients.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):7442-9.
2007: Asifa S Haider; Irma Cardinale; Julia A Whynot; James G Krueger
Effects of etanercept are distinct from infliximab in modulating proinflammatory genes in activated human leukocytes.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2007;12(1):9-15.
2007: Emma Guttman-Yassky; Michelle A Lowes; Judilyn Fuentes-Duculan; Julia A Whynot; Inna Novitskaya; Irma Cardinale; Asifa S Haider; Artemis Khatcherian; John A Carucci; Reuven Bergman; James G Krueger
Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis.
The Journal of allergy and clinical immunology 2007;119(5):1210-7.
2007: Michelle A Lowes; Anne M Bowcock; James G Krueger
Pathogenesis and therapy of psoriasis.
Nature 2007;445(7130):866-73.
2007: Francesca Chamian; Shao-Lee Lin; Edmund Lee; Toyoko Kikuchi; Patricia Gilleaudeau; Mary Sullivan-Whalen; Irma Cardinale; Artemis Khatcherian; Inna Novitskaya; Knut M Wittkowski; James G Krueger; Michelle A Lowes
Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis.
Journal of translational medicine 2007;5():27.
2007: Michelle A Lowes; Francesca Chamian; Maria Veronica Abello; Craig L Leonardi; Wolfgang Dummer; Kim A Papp; James G Krueger
Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series.
BMC dermatology 2007;7():2.
2006: Rama Malaviya; Yvonne Sun; Jennifer K Tan; Andrew Wang; Melissa Magliocco; Melissa Yao; James G Krueger; Alice B Gottlieb
Etanercept induces apoptosis of dermal dendritic cells in psoriatic plaques of responding patients.
Journal of the American Academy of Dermatology 2006;55(4):590-7.
2006: Frank Wang; Edmund Lee; Michelle A Lowes; Asifa S Haider; Judilyn Fuentes-Duculan; Maria Veronica Abello; Francesca Chamian; Irma Cardinale; James G Krueger
Prominent production of IL-20 by CD68+/CD11c+ myeloid-derived cells in psoriasis: Gene regulation and cellular effects.
The Journal of investigative dermatology 2006;126(7):1590-9.
2006: Asifa S Haider; Sara B Peters; Helen Kaporis; Irma Cardinale; Ji Fei; Jurg Ott; Miki Blumenberg; Anne M Bowcock; James G Krueger; John A Carucci
Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia.
The Journal of investigative dermatology 2006;126(4):869-81.
2006: Asifa S Haider; Judilyn Duculan; Julia A Whynot; James G Krueger
Increased JunB mRNA and protein expression in psoriasis vulgaris lesions.
The Journal of investigative dermatology 2006;126(4):912-4.
2005: Michelle A Lowes; Francesca Chamian; Maria Veronica Abello; Judilyn Fuentes-Duculan; Shao-Lee Lin; RACHEL NUSSBAUM; Inna Novitskaya; Henrietta Carbonaro; Irma Cardinale; Toyoko Kikuchi; Patricia Gilleaudeau; Mary Sullivan-Whalen; Knut M Wittkowski; Kim A Papp; Marvin Garovoy; Wolfgang Dummer; Ralph M Steinman; James G Krueger
Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a).
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19057-62.
2005: Anne M Bowcock; James G Krueger
Getting under the skin: the immunogenetics of psoriasis.
Nature reviews. Immunology 2005;5(9):699-711.
2005: Alice B Gottlieb; Francesca Chamian; Salman Masud; Irma Cardinale; Maria Veronica Abello; Michelle A Lowes; Fei Chen; Melissa Magliocco; James G Krueger
TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2721-9.
2005: Deborah L Mortensen; Patricia A Walicke; Xiaolin Wang; Paul Kwon; Peter Kuebler; Alice B Gottlieb; James G Krueger; Craig L Leonardi; Bruce Miller; Amita Joshi
Pharmacokinetics and pharmacodynamics of multiple weekly subcutaneous efalizumab doses in patients with plaque psoriasis.
Journal of clinical pharmacology 2005;45(3):286-98.
2005: Francesca Chamian; Michelle A Lowes; Shao-Lee Lin; Edmund Lee; Toyoko Kikuchi; Patricia Gilleaudeau; Mary Sullivan-Whalen; Irma Cardinale; Artemis Khatcherian; Inna Novitskaya; Knut M Wittkowski; James G Krueger
Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2075-80.
2005: Michelle A Lowes; James A Turton; James G Krueger; Ross StC Barnetson
Psoriasis vulgaris flare during efalizumab therapy does not preclude future use: a case series.
BMC dermatology 2005;5():9.
2004: Michelle A Lowes; Wook Lew; James G Krueger
Current concepts in the immunopathogenesis of psoriasis.
Dermatologic clinics 2004;22(4):349-69, vii.
2004: Yulia Vugmeyster; Toyoko Kikuchi; Michelle A Lowes; Francesca Chamian; Mark Kagen; Patricia Gilleaudeau; Edmund Lee; Kathy Howell; Sarah Bodary; Wolfgang Dummer; James G Krueger
Efalizumab (anti-CD11a)-induced increase in peripheral blood leukocytes in psoriasis patients is preferentially mediated by altered trafficking of memory CD8+ T cells into lesional skin.
Clinical immunology (Orlando, Fla.) 2004;113(1):38-46.
2004: Francesca Chamian; James G Krueger
Psoriasis vulgaris: an interplay of T lymphocytes, dendritic cells, and inflammatory cytokines in pathogenesis.
Current opinion in rheumatology 2004;16(4):331-7.
2004: Wook Lew; Anne M Bowcock; James G Krueger
Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and "Type 1" inflammatory gene expression.
Trends in immunology 2004;25(6):295-305.
2004: Knut M Wittkowski; Edmund Lee; RACHEL NUSSBAUM; Francesca Chamian; James G Krueger
Combining several ordinal measures in clinical studies.
Statistics in medicine 2004;23(10):1579-92.
2004: W Lew; E Lee; James G Krueger
Psoriasis genomics: analysis of proinflammatory (type 1) gene expression in large plaque (Western) and small plaque (Asian) psoriasis vulgaris.
The British journal of dermatology 2004;150(4):668-76.
2004: Edmund Lee; William L Trepicchio; Judith L Oestreicher; Debra Pittman; Frank Wang; Francesca Chamian; Madhav V Dhodapkar; James G Krueger
Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris.
The Journal of experimental medicine 2004;199(1):125-30.
2003: Cynthia Helms; Li Cao; James G Krueger; Ellen M Wijsman; Francesca Chamian; Derek Gordon; Michael Heffernan; Jil A Wright Daw; Jason Robarge; Jurg Ott; Pui-Yan Kwok; Alan Menter; Anne M Bowcock
A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis.
Nature genetics 2003;35(4):349-56.
2003: Ian B Walters; Maki Ozawa; Irma Cardinale; Patricia Gilleaudeau; William L Trepicchio; Judith Bliss; James G Krueger
Narrowband (312-nm) UV-B suppresses interferon gamma and interleukin (IL) 12 and increases IL-4 transcripts: differential regulation of cytokines at the single-cell level.
Archives of dermatology 2003;139(2):155-61.
2002: Alice B Gottlieb; James G Krueger; Knut Wittkowski; Russell Dedrick; Patricia A Walicke; Marvin Garovoy
Psoriasis as a model for T-cell-mediated disease: immunobiologic and clinical effects of treatment with multiple doses of efalizumab, an anti-CD11a antibody.
Archives of dermatology 2002;138(5):591-600.
2002: Stephen J Oliver; Toyoko Kikuchi; James G Krueger; Gilla Kaplan
Thalidomide induces granuloma differentiation in sarcoid skin lesions associated with disease improvement.
Clinical immunology (Orlando, Fla.) 2002;102(3):225-36.
2002: RACHEL NUSSBAUM; James G Krueger
Treatment of inflammatory dermatoses with novel biologic agents: a primer.
Advances in dermatology 2002;18():45-89.
2002: James G Krueger
The immunologic basis for the treatment of psoriasis with new biologic agents.
Journal of the American Academy of Dermatology 2002;46(1):1-23; quiz 23-6.
2001: Kim A Papp; Robert Bissonnette; James G Krueger; Wayne Carey; D Gratton; Wayne Gulliver; Harvey Lui; Charles Lynde; A Magee; D Minier; J P Ouellet; P Patel; J Shapiro; Neil H Shear; S Kramer; Patricia A Walicke; R Bauer; Russell Dedrick; S S Kim; Mark White; Marvin Garovoy
The treatment of moderate to severe psoriasis with a new anti-CD11a monoclonal antibody.
Journal of the American Academy of Dermatology 2001;45(5):665-74.
2001: Judith L Oestreicher; Ian B Walters; T Kikuchi; Patricia Gilleaudeau; J Surette; Ullrich S Schwertschlag; Andrew J Dorner; James G Krueger; William L Trepicchio
Molecular classification of psoriasis disease-associated genes through pharmacogenomic expression profiling.
The pharmacogenomics journal 2001;1(4):272-87.
2001: M Boschmann; FP Murphy; James G Krueger
Microdialysis can detect age-related differences in glucose distribution within the dermis and subcutaneous adipose tissue.
Dermatology (Basel, Switzerland) 2001;202(3):207-10.
2000: Alice B Gottlieb; Mark Lebwohl; S Shirin; A Sherr; Patricia Gilleaudeau; G Singer; G Solodkina; R Grossman; E Gisoldi; S Phillips; H M Neisler; James G Krueger
Anti-CD4 monoclonal antibody treatment of moderate to severe psoriasis vulgaris: results of a pilot, multicenter, multiple-dose, placebo-controlled study.
Journal of the American Academy of Dermatology 2000;43(4):595-604.
2000: James G Krueger; Ian B Walters; M Miyazawa; Patricia Gilleaudeau; J Hakimi; Susan Light; A Sherr; Alice B Gottlieb
Successful in vivo blockade of CD25 (high-affinity interleukin 2 receptor) on T cells by administration of humanized anti-Tac antibody to patients with psoriasis.
Journal of the American Academy of Dermatology 2000;43(3):448-58.
2000: Alice Gottlieb; James G Krueger; R Bright; Mark Ling; Mark Lebwohl; Sewon Kang; S Feldman; M Spellman; K Wittkowski; H D Ochs; P Jardieu; R Bauer; Mark White; Russell Dedrick; Marvin Garovoy
Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis.
Journal of the American Academy of Dermatology 2000;42(3):428-35.
2000: K Ferenczi; LH Burack; Melissa Pope; James G Krueger; LM Austin
CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry.
Journal of autoimmunity 2000;14(1):63-78.
1999: FP Murphy; TR Coven; LH Burack; Patricia Gilleaudeau; Irma Cardinale; R Auerbach; James G Krueger
Clinical clearing of psoriasis by 6-thioguanine correlates with cutaneous T-cell depletion via apoptosis: evidence for selective effects on activated T lymphocytes.
Archives of dermatology 1999;135(12):1495-502.
1999: William L Trepicchio; M Ozawa; Ian B Walters; T Kikuchi; Patricia Gilleaudeau; JL Bliss; Ullrich S Schwertschlag; Andrew J Dorner; James G Krueger
Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions.
The Journal of clinical investigation 1999;104(11):1527-37.
1999: L M Austin; Maki Ozawa; T Kikuchi; Ian B Walters; James G Krueger
The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients.
The Journal of investigative dermatology 1999;113(5):752-9.
1999: Ian B Walters; LH Burack; TR Coven; Patricia Gilleaudeau; James G Krueger
Suberythemogenic narrow-band UVB is markedly more effective than conventional UVB in treatment of psoriasis vulgaris.
Journal of the American Academy of Dermatology 1999;40(6 Pt 1):893-900.
1999: Maki Ozawa; K Ferenczi; T Kikuchi; Irma Cardinale; LM Austin; TR Coven; LH Burack; James G Krueger
312-nanometer ultraviolet B light (narrow-band UVB) induces apoptosis of T cells within psoriatic lesions.
The Journal of experimental medicine 1999;189(4):711-8.
1999: TR Coven; Ian B Walters; Irma Cardinale; James G Krueger
PUVA-induced lymphocyte apoptosis: mechanism of action in psoriasis.
Photodermatology, photoimmunology & photomedicine 1999;15(1):22-7.
1998: TR Coven; FP Murphy; Patricia Gilleaudeau; Irma Cardinale; James G Krueger
Trimethylpsoralen bath PUVA is a remittive treatment for psoriasis vulgaris. Evidence that epidermal immunocytes are direct therapeutic targets.
Archives of dermatology 1998;134(10):1263-8.
1998: LM Austin; TR Coven; Nina Bhardwaj; R Steinman; James G Krueger
Intraepidermal lymphocytes in psoriatic lesions are activated GMP-17(TIA-1)+CD8+CD3+ CTLs as determined by phenotypic analysis.
Journal of cutaneous pathology 1998;25(2):79-88.
1997: TR Coven; LH Burack; R Gilleaudeau; M Keogh; Maki Ozawa; James G Krueger
Narrowband UV-B produces superior clinical and histopathological resolution of moderate-to-severe psoriasis in patients compared with broadband UV-B.
Archives of dermatology 1997;133(12):1514-22.
1997: Paul W Finch; F Murphy; Irma Cardinale; James G Krueger
Altered expression of keratinocyte growth factor and its receptor in psoriasis.
The American journal of pathology 1997;151(6):1619-28.
1997: Miriam V Rivas; Erich D Jarvis; S Morisaki; H Carbonaro; Alice B Gottlieb; James G Krueger
Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique.
The Journal of investigative dermatology 1997;108(2):188-94.
1996: I Lu; Patricia Gilleaudeau; J A McLane; N Heftler; M Kamber; S Gottlieb; James G Krueger; A B Gottlieb
Modulation of epidermal differentiation, tissue inflammation, and T-lymphocyte infilitration in psoriatic plaques by topical calcitriol.
Journal of cutaneous pathology 1996;23(5):419-30.
1996: S Gottlieb; E Hayes; Patricia Gilleaudeau; Irma Cardinale; A B Gottlieb; James G Krueger
Cellular actions of etretinate in psoriasis: enhanced epidermal differentiation and reduced cell-mediated inflammation are unexpected outcomes.
Journal of cutaneous pathology 1996;23(5):404-18.
1996: R Johnson; L Staiano-Coico; L Austin; Irma Cardinale; R Nabeya-Tsukifuji; James G Krueger
PUVA treatment selectively induces a cell cycle block and subsequent apoptosis in human T-lymphocytes.
Photochemistry and photobiology 1996;63(5):566-71.
1996: E Hodak; A B Gottlieb; M Anzilotti; James G Krueger
The insulin-like growth factor 1 receptor is expressed by epithelial cells with proliferative potential in human epidermis and skin appendages: correlation of increased expression with epidermal hyperplasia.
The Journal of investigative dermatology 1996;106(3):564-70.
1996: E Hodak; A B Gottlieb; S Colen; M Anzilotti; James G Krueger
In vivo expression of the insulin-like growth factor-I (IGF-I) receptor in congenital pigmented nevi.
Journal of cutaneous pathology 1996;23(1):19-24.
1995: James G Krueger; J T Wolfe; R T Nabeya; V P Vallat; Patricia Gilleaudeau; N S Heftler; L M Austin; A B Gottlieb
Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells.
The Journal of experimental medicine 1995;182(6):2057-68.
1995: S L Gottlieb; N S Heftler; Patricia Gilleaudeau; R Johnson; V P Vallat; J Wolfe; A B Gottlieb; James G Krueger
Short-contact anthralin treatment augments therapeutic efficacy of cyclosporine in psoriasis: a clinical and pathologic study.
Journal of the American Academy of Dermatology 1995;33(4):637-45.
1995: S L Gottlieb; Patricia Gilleaudeau; R Johnson; L Estes; T G Woodworth; A B Gottlieb; James G Krueger
Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis.
Nature medicine 1995;1(5):442-7.
1994: S Braunstein; Gilla Kaplan; A B Gottlieb; M Schwartz; G Walsh; Rodolfo M Abalos; Tranquilino T Fajardo; L S Guido; James G Krueger
GM-CSF activates regenerative epidermal growth and stimulates keratinocyte proliferation in human skin in vivo.
The Journal of investigative dermatology 1994;103(4):601-4.
1994: V P Vallat; Patricia Gilleaudeau; L Battat; J Wolfe; R Nabeya; N Heftler; E Hodak; A B Gottlieb; James G Krueger
PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis: a possible cellular basis for remittive therapy.
The Journal of experimental medicine 1994;180(1):283-96.
1994: I Tamm; Irma Cardinale; T Kikuchi; James G Krueger
E-cadherin distribution in interleukin 6-induced cell-cell separation of ductal breast carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4338-42.
1994: I Tamm; T Kikuchi; Irma Cardinale; James G Krueger
Cell-adhesion-disrupting action of interleukin 6 in human ductal breast carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3329-33.
1993: Y Zhao; H Uyttendaele; James G Krueger; Marius Sudol; Hidesaburo Hanafusa
Inactivation of c-Yes tyrosine kinase by elevation of intracellular calcium levels.
Molecular and cellular biology 1993;13(12):7507-14.
1993: Lisa Staiano-Coico; James G Krueger; J S Rubin; S D'limi; V P Vallat; L Valentino; T Fahey; A Hawes; G Kingston; M R Madden
Human keratinocyte growth factor effects in a porcine model of epidermal wound healing.
The Journal of experimental medicine 1993;178(3):865-78.
1993: John C Ansel; J P Tiesman; John E Olerud; James G Krueger; J F Krane; D C Tara; G D Shipley; D Gilbertson; M L Usui; CE Hart
Human keratinocytes are a major source of cutaneous platelet-derived growth factor.
The Journal of clinical investigation 1993;92(2):671-8.
1992: A B Gottlieb; L Khandke; J F Krane; Lisa Staiano-Coico; R Ashinoff; James G Krueger
Anthralin decreases keratinocyte TGF-alpha expression and EGF-receptor binding in vitro.
The Journal of investigative dermatology 1992;98(5):680-5.
1992: J F Krane; A B Gottlieb; D M Carter; James G Krueger
The insulin-like growth factor I receptor is overexpressed in psoriatic epidermis, but is differentially regulated from the epidermal growth factor receptor.
The Journal of experimental medicine 1992;175(4):1081-90.
1992: A B Gottlieb; R M Grossman; L Khandke; D M Carter; Pravin B Sehgal; S M Fu; Angela Granelli-Piperno; M Rivas; L Barazani; James G Krueger
Studies of the effect of cyclosporine in psoriasis in vivo: combined effects on activated T lymphocytes and epidermal regenerative maturation.
The Journal of investigative dermatology 1992;98(3):302-9.
1991: A B Gottlieb; James G Krueger; L Khandke; R M Grossman; J Krane; D M Carter
Role of T cell activation in the pathogenesis of psoriasis.
Annals of the New York Academy of Sciences 1991;636():377-9.
1991: James G Krueger; A N Lin; I Leong; D M Carter
Junctional epidermolysis bullosa keratinocytes in culture display adhesive, structural, and functional abnormalities.
The Journal of investigative dermatology 1991;97(5):849-61.
1991: L Khandke; J F Krane; R Ashinoff; Lisa Staiano-Coico; Angela Granelli-Piperno; A D Luster; D M Carter; James G Krueger; A B Gottlieb
Cyclosporine in psoriasis treatment. Inhibition of keratinocyte cell-cycle progression in G1 independent of effects on transforming growth factor alpha/epidermal growth factor receptor pathways.
Archives of dermatology 1991;127(8):1172-9.
1991: J F Krane; D P Murphy; A B Gottlieb; D M Carter; CE Hart; James G Krueger
Increased dermal expression of platelet-derived growth factor receptors in growth-activated skin wounds and psoriasis.
The Journal of investigative dermatology 1991;96(6):983-6.
1991: J F Krane; D P Murphy; D M Carter; James G Krueger
Synergistic effects of epidermal growth factor (EGF) and insulin-like growth factor I/somatomedin C (IGF-I) on keratinocyte proliferation may be mediated by IGF-I transmodulation of the EGF receptor.
The Journal of investigative dermatology 1991;96(4):419-24.
1990: Lisa Staiano-Coico; L Khandke; J F Krane; S Sharif; A B Gottlieb; James G Krueger; L Heim; B Rigas; P J Higgins
TGF-alpha and TGF-beta expression during sodium-N-butyrate-induced differentiation of human keratinocytes: evidence for subpopulation-specific up-regulation of TGF-beta mRNA in suprabasal cells.
Experimental cell research 1990;191(2):286-91.
1990: Y H Zhao; James G Krueger; Marius Sudol
Expression of cellular-yes protein in mammalian tissues.
Oncogene 1990;5(11):1629-35.
1990: A B Gottlieb; James G Krueger
HLA region genes and immune activation in the pathogenesis of psoriasis.
Archives of dermatology 1990;126(8):1083-6.
1990: James G Krueger; J F Krane; D M Carter; A B Gottlieb
Role of growth factors, cytokines, and their receptors in the pathogenesis of psoriasis.
The Journal of investigative dermatology 1990;94(6 Suppl):135S-140S.