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Robert Krug

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Chen Zhao; Mark N Collins; Tien-Ying Hsiang; Robert M Krug
Interferon-induced ISG15 pathway: an ongoing virus-host battle.
Meghana Malur; Michael Gale; Robert M Krug
LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3.
Tien-Ying Hsiang; Ligang Zhou; Robert M Krug
Roles of the phosphorylation of specific serines and threonines in the NS1 protein of human influenza A viruses.

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All Publications

2013: Chen Zhao; Mark N Collins; Tien-Ying Hsiang; Robert M Krug
Interferon-induced ISG15 pathway: an ongoing virus-host battle.
Trends in microbiology 2013;21(4):181-6.
2012: Meghana Malur; Michael Gale; Robert M Krug
LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3.
Journal of virology 2012;86(19):10733-8.
2012: Tien-Ying Hsiang; Ligang Zhou; Robert M Krug
Roles of the phosphorylation of specific serines and threonines in the NS1 protein of human influenza A viruses.
Journal of virology 2012;86(19):10370-6.
2012: Jesper K Marklund; Yizhi Jane Tao; Qiaozhen Ye; Jinhui Dong; Robert M Krug
Sequence in the influenza A virus nucleoprotein required for viral polymerase binding and RNA synthesis.
Journal of virology 2012;86(13):7292-7.
2012: Eun Jeong Cho; Eric V Anslyn; Robert M Krug; Li-Chung Ma; Gaetano T Montelione; Jon Robertus; Shuangluo Xia; Andrew D Ellington
Identification of influenza virus inhibitors targeting NS1A utilizing fluorescence polarization-based high-throughput assay.
Journal of biomolecular screening 2012;17(4):448-59.
2012: Qiaozhen Ye; Tom S Y Guu; Robert M Krug; Rei-Lin Kuo; Douglas A Mata; Bartram Smith; Yizhi Jane Tao
Biochemical and structural evidence in support of a coherent model for the formation of the double-helical influenza A virus ribonucleoprotein.
mBio 2012;4(1):e00467-12.
2011: Cuifeng Yin; G V T Swapna; James M Aramini; John R Cort; Robert M Krug; Li-Chung Ma; Gaetano T Montelione
Backbone and Ile-δ1, Leu, Val methyl 1H, 13C and 15N NMR chemical shift assignments for human interferon-stimulated gene 15 protein.
Biomolecular NMR assignments 2011;5(2):215-9.
2011: Rongjin Guan; Robert M Krug; Paul G Leonard; Li-Chung Ma; Haripriya Sridharan; Chen Zhao; Brendan R Amer; Gaetano T Montelione
Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13468-73.
2011: James M Aramini; Colleen T Ciccosanti; Keith Hamilton; Robert M Krug; Hsiau-Wei Lee; Li-Chung Ma; Timothy R Mack; Curtis M Schauder; Rong Xiao; Li Zhao; Ligang Zhou; Brendan R Amer; Gaetano T Montelione
Dimer interface of the effector domain of non-structural protein 1 from influenza A virus: an interface with multiple functions.
The Journal of biological chemistry 2011;286(29):26050-60.
2011: Lei You; Eun Jeong Cho; John Leavitt; Li-Chung Ma; Gaetano T Montelione; Eric V Anslyn; Robert M Krug; Andrew Ellington; Jon D Robertus
Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(10):3007-11.
2010: Curtis Schauder; Li Chung Ma; Robert M Krug; Gaetano T Montelione; Rongjin Guan
Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85β subunit reveals conformational plasticity in the interhelical turn region.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 12):1567-71.
2010: Kalyan Das; James M Aramini; Li-Chung Ma; Robert M Krug; Eddy Arnold
Structures of influenza A proteins and insights into antiviral drug targets.
Nature structural & molecular biology 2010;17(5):530-8.
2010: Haripriya Sridharan; Chen Zhao; Robert M Krug
Species specificity of the NS1 protein of influenza B virus: NS1 binds only human and non-human primate ubiquitin-like ISG15 proteins.
The Journal of biological chemistry 2010;285(11):7852-6.
2010: Chen Zhao; Tien-Ying Hsiang; Rei-Lin Kuo; Robert M Krug
ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):2253-8.
2009: Robert M Krug; James M Aramini
Emerging antiviral targets for influenza A virus.
Trends in pharmacological sciences 2009;30(6):269-77.
2009: Tien-Ying Hsiang; Chen Zhao; Robert M Krug
Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells.
Journal of virology 2009;83(12):5971-7.
2009: Rei-Lin Kuo; Robert M Krug
Influenza a virus polymerase is an integral component of the CPSF30-NS1A protein complex in infected cells.
Journal of virology 2009;83(4):1611-6.
2009: Laura L Newcomb; Rei-Lin Kuo; Qiaozhen Ye; Yunyun Jiang; Yizhi Jane Tao; Robert M Krug
Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication.
Journal of virology 2009;83(1):29-36.
2008: Kalyan Das; Li-Chung Ma; Rong Xiao; Brian Radvansky; James M Aramini; Li Zhao; Jesper Marklund; Rei-Lin Kuo; Karen Y Twu; Eddy Arnold; Robert M Krug; Gaetano T Montelione
Structural basis for suppression of a host antiviral response by influenza A virus.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):13093-8.
2007: Karen Y Twu; Rei-Lin Kuo; Jesper Marklund; Robert M Krug
The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells.
Journal of virology 2007;81(15):8112-21.
2007: Cuifeng Yin; Javed A Khan; G V T Swapna; Asli Ertekin; Robert M Krug; Liang Tong; Gaetano T Montelione
Conserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses.
The Journal of biological chemistry 2007;282(28):20584-92.
2007: Ji-Young Min; Shoudong Li; Ganes C Sen; Robert M Krug
A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis.
Virology 2007;363(1):236-43.
2007: Krister Melén; Leena Kinnunen; Riku Fagerlund; Niina Ikonen; Karen Y Twu; Robert M Krug; Ilkka Julkunen
Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes.
Journal of virology 2007;81(11):5995-6006.
2006: Jukka Sirén; Tadaatsu Imaizumi; Devanand Sarkar; Taija E Pietilä; Diana L Noah; Rongtuan Lin; John Hiscott; Robert M Krug; Paul B Fisher; Ilkka Julkunen; Sampsa Matikainen
Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines.
Microbes and infection / Institut Pasteur 2006;8(8):2013-20.
2006: Ji-Young Min; Robert M Krug
The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):7100-5.
2006: Karen Y Twu; Diana L Noah; Ping Rao; Rei-Lin Kuo; Robert M Krug
The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target.
Journal of virology 2006;80(8):3957-65.
2006: Robert M Krug
Virology. Clues to the virulence of H5N1 viruses in humans.
Science (New York, N.Y.) 2006;311(5767):1562-3.
2006: Anahita Dastur; Sylvie Beaudenon; Melissa Kelley; Robert M Krug; Jon M Huibregtse
Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells.
The Journal of biological chemistry 2006;281(7):4334-8.
2005: Chen Zhao; Carilee Denison; Jon M Huibregtse; Steven P Gygi; Robert M Krug
Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10200-5.
2005: Diana L Noah; Robert M Krug
Influenza virus virulence and its molecular determinants.
Advances in virus research 2005;65():121-45.
2005: Robert M Krug; Chen Zhao; Sylvie Beaudenon
Properties of the ISG15 E1 enzyme UbE1L.
Methods in enzymology 2005;398():32-40.
2004: Chen Zhao; Sylvie Beaudenon; Melissa L Kelley; M Brett Waddell; Weiming Yuan; Brenda A Schulman; Jon M Huibregtse; Robert M Krug
The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(20):7578-82.
2004: Chen-ya Chien; Yujia Xu; Rong Xiao; James M Aramini; Parag V Sahasrabudhe; Robert M Krug; Gaetano T Montelione
Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: evidence for a novel RNA-binding mode.
Biochemistry 2004;43(7):1950-62.
2003: Robert M Krug; Weiming Yuan; Diana L Noah; Anita Ghate Latham
Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein.
Virology 2003;309(2):181-9.
2003: Diana L Noah; Karen Y Twu; Robert M Krug
Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS.
Virology 2003;307(2):386-95.
2003: Ping Rao; Weiming Yuan; Robert M Krug
Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis.
The EMBO journal 2003;22(5):1188-98.
2003: Robert M Krug
The potential use of influenza virus as an agent for bioterrorism.
Antiviral research 2003;57(1-2):147-50.
2002: Weiming Yuan; James M Aramini; Gaetano T Montelione; Robert M Krug
Structural basis for ubiquitin-like ISG 15 protein binding to the NS1 protein of influenza B virus: a protein-protein interaction function that is not shared by the corresponding N-terminal domain of the NS1 protein of influenza A virus.
Virology 2002;304(2):291-301.
2002: Mee-Jung Kim; Anita Ghate Latham; Robert M Krug
Human influenza viruses activate an interferon-independent transcription of cellular antiviral genes: outcome with influenza A virus is unique.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10096-101.
2001: M C Cassetti; Diana L Noah; Gaetano T Montelione; Robert M Krug
Efficient translation of mRNAs in influenza A virus-infected cells is independent of the viral 5' untranslated region.
Virology 2001;289(2):180-5.
2001: Y Li; Z Y Chen; W Wang; Carl Baker; Robert M Krug
The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo.
RNA (New York, N.Y.) 2001;7(6):920-31.
2001: M L Li; Ping Rao; Robert M Krug
The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits.
The EMBO journal 2001;20(8):2078-86.
2001: Weiming Yuan; Robert M Krug
Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein.
The EMBO journal 2001;20(3):362-71.
2000: Z Chen; Robert M Krug
Selective nuclear export of viral mRNAs in influenza-virus-infected cells.
Trends in microbiology 2000;8(8):376-83.
1999: Z Chen; Y Li; Robert M Krug
Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery.
The EMBO journal 1999;18(8):2273-83.
1999: W Wang; K Riedel; P Lynch; Chen-ya Chien; Gaetano T Montelione; Robert M Krug
RNA binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids.
RNA (New York, N.Y.) 1999;5(2):195-205.
1998: M L Li; B C Ramirez; Robert M Krug
RNA-dependent activation of primer RNA production by influenza virus polymerase: different regions of the same protein subunit constitute the two required RNA-binding sites.
The EMBO journal 1998;17(19):5844-52.
1998: M E Nemeroff; Silvia Barabino; Y Li; W Keller; Robert M Krug
Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs.
Molecular cell 1998;1(7):991-1000.
1998: Y Li; Yoshihiko Yamakita; Robert M Krug
Regulation of a nuclear export signal by an adjacent inhibitory sequence: the effector domain of the influenza virus NS1 protein.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):4864-9.
1998: Z Chen; Y Li; Robert M Krug
Chimeras containing influenza NS1 and HIV-1 Rev protein sequences: mechanism of their inhibition of nuclear export of Rev protein-RNA complexes.
Virology 1998;241(2):234-50.
1998: W Wang; Robert M Krug
U6atac snRNA, the highly divergent counterpart of U6 snRNA, is the specific target that mediates inhibition of AT-AC splicing by the influenza virus NS1 protein.
RNA (New York, N.Y.) 1998;4(1):55-64.
1997: J Liu; P A Lynch; Chen-ya Chien; Gaetano T Montelione; Robert M Krug; Helen Berman
Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein.
Nature structural biology 1997;4(11):896-9.
1997: Chen-ya Chien; Roberto Tejero; Y Huang; DE Zimmerman; C B Ríos; Robert M Krug; Gaetano T Montelione
A novel RNA-binding motif in influenza A virus non-structural protein 1.
Nature structural biology 1997;4(11):891-5.
1996: S R Shih; Robert M Krug
Surprising function of the three influenza viral polymerase proteins: selective protection of viral mRNAs against the cap-snatching reaction catalyzed by the same polymerase proteins.
Virology 1996;226(2):430-5.
1996: S R Shih; Robert M Krug
Novel exploitation of a nuclear function by influenza virus: the cellular SF2/ASF splicing factor controls the amount of the essential viral M2 ion channel protein in infected cells.
The EMBO journal 1996;15(19):5415-27.
1996: W Wang; Robert M Krug
The RNA-binding and effector domains of the viral NS1 protein are conserved to different extents among influenza A and B viruses.
Virology 1996;223(1):41-50.
1996: X Y Qian; Z Y Chen; J Zhang; A B Rabson; Robert M Krug
New approach for inhibiting Rev function and HIV-1 production using the influenza virus NS1 protein.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):8873-7.
1995: Y Lu; M Wambach; Michael G Katze; Robert M Krug
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor.
Virology 1995;214(1):222-8.
1995: X Y Qian; Chen-ya Chien; Y Lu; Gaetano T Montelione; Robert M Krug
An amino-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and largely helical backbone structure.
RNA (New York, N.Y.) 1995;1(9):948-56.
1995: M E Nemeroff; X Y Qian; Robert M Krug
The influenza virus NS1 protein forms multimers in vitro and in vivo.
Virology 1995;212(2):422-8.
1995: S R Shih; M E Nemeroff; Robert M Krug
The choice of alternative 5' splice sites in influenza virus M1 mRNA is regulated by the viral polymerase complex.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6324-8.
1995: Yun Qiu; M Nemeroff; Robert M Krug
The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing.
RNA (New York, N.Y.) 1995;1(3):304-16.
1994: Y Lu; X Y Qian; Robert M Krug
The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing.
Genes & development 1994;8(15):1817-28.
1994: X Y Qian; F Alonso-Caplen; Robert M Krug
Two functional domains of the influenza virus NS1 protein are required for regulation of nuclear export of mRNA.
Journal of virology 1994;68(4):2433-41.
1994: Yun Qiu; Robert M Krug
The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A).
Journal of virology 1994;68(4):2425-32.
1992: M E Nemeroff; U Utans; Angela Krämer; Robert M Krug
Identification of cis-acting intron and exon regions in influenza virus NS1 mRNA that inhibit splicing and cause the formation of aberrantly sedimenting presplicing complexes.
Molecular and cellular biology 1992;12(3):962-70.
1992: F V Alonso-Caplen; M E Nemeroff; Yun Qiu; Robert M Krug
Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA.
Genes & development 1992;6(2):255-67.
1991: F V Alonso-Caplen; Robert M Krug
Regulation of the extent of splicing of influenza virus NS1 mRNA: role of the rates of splicing and of the nucleocytoplasmic transport of NS1 mRNA.
Molecular and cellular biology 1991;11(2):1092-8.
1990: B Broni; Ilkka Julkunen; Jon H Condra; Mary-Ellen Davies; M J Berry; Robert M Krug
Parental influenza virion nucleocapsids are efficiently transported into the nuclei of murine cells expressing the nuclear interferon-induced Mx protein.
Journal of virology 1990;64(12):6335-40.
1989: C H Agris; M E Nemeroff; Robert M Krug
A block in mammalian splicing occurring after formation of large complexes containing U1, U2, U4, U5, and U6 small nuclear ribonucleoproteins.
Molecular and cellular biology 1989;9(1):259-67.
1988: Geoffrey I Shapiro; Robert M Krug
Influenza virus RNA replication in vitro: synthesis of viral template RNAs and virion RNAs in the absence of an added primer.
Journal of virology 1988;62(7):2285-90.
1988: F V Alonso-Caplen; M G Katze; Robert M Krug
Efficient transcription, not translation, is dependent on adenovirus tripartite leader sequences at late times of infection.
Journal of virology 1988;62(5):1606-16.
1987: C St Angelo; G E Smith; M D Summers; Robert M Krug
Two of the three influenza viral polymerase proteins expressed by using baculovirus vectors form a complex in insect cells.
Journal of virology 1987;61(2):361-5.
1987: B M Detjen; C St Angelo; M G Katze; Robert M Krug
The three influenza virus polymerase (P) proteins not associated with viral nucleocapsids in the infected cell are in the form of a complex.
Journal of virology 1987;61(1):16-22.
1987: Robert M Krug; C St Angelo; B Broni; G Shapiro
Transcription and replication of influenza virion RNA in the nucleus of infected cells.
Cold Spring Harbor symposia on quantitative biology 1987;52():353-8.
1986: S J Plotch; Robert M Krug
In vitro splicing of influenza viral NS1 mRNA and NS1-beta-globin chimeras: possible mechanisms for the control of viral mRNA splicing.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(15):5444-8.
1985: Robert M Krug; M Shaw; B Broni; G Shapiro; Otto Haller
Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product.
Journal of virology 1985;56(1):201-6.
1983: J Braam; I Ulmanen; Robert M Krug
Molecular model of a eucaryotic transcription complex: functions and movements of influenza P proteins during capped RNA-primed transcription.
Cell 1983;34(2):609-18.
1983: I Ulmanen; B Broni; Robert M Krug
Influenza virus temperature-sensitive cap (m7GpppNm)-dependent endonuclease.
Journal of virology 1983;45(1):27-35.
1982: M H Heggeness; P R Smith; I Ulmanen; Robert M Krug; P W Choppin
Studies on the helical nucleocapsid of influenza virus.
Virology 1982;118(2):466-70.
1981: I Ulmanen; B A Broni; Robert M Krug
Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7GpppNm) on RNAs and in initiating viral RNA transcription.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(12):7355-9.
1981: S J Plotch; M Bouloy; I Ulmanen; Robert M Krug
A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription.
Cell 1981;23(3):847-58.
1980: Robert M Krug; B A Broni; A J LaFiandra; M A Morgan; A J Shatkin
Priming and inhibitory activities of RNAs for the influenza viral transcriptase do not require base pairing with the virion template RNA.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(10):5874-8.
1980: M Bouloy; S J Plotch; Robert M Krug
Both the 7-methyl and the 2'-O-methyl groups in the cap of mRNA strongly influence its ability to act as primer for influenza virus RNA transcription.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(7):3952-6.
1980: H D Robertson; E Dickson; S J Plotch; Robert M Krug
Identification of the RNA region transferred from a representative primer, beta-globin mRNA, to influenza mRNA during in vitro transcription.
Nucleic acids research 1980;8(5):925-42.
1980: Robert M Krug; M Bouloy; S J Plotch
RNA primers and the role of host nuclear RNA polymerase II in influenza viral RNA transcription.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1980;288(1029):359-70.