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Michael Kruhlak

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Laurence Lamy; Ola Landgren; Vinod Nair; Vu N Ngo; Arthur L Shaffer; N C Tolga Emre; Michael J Kruhlak; Erming Tian; Yandan Yang; Adriana Zingone; Louis M Staudt
Control of autophagic cell death by caspase-10 in multiple myeloma.
Michael J Kruhlak
Correlative fluorescence and EFTEM imaging of the organized components of the mammalian nucleus.
Alioscka A Sousa; Michael J Kruhlak
Introduction: nanoimaging techniques in biology.

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All Publications

2013: Laurence Lamy; Ola Landgren; Vinod Nair; Vu N Ngo; Arthur L Shaffer; N C Tolga Emre; Michael J Kruhlak; Erming Tian; Yandan Yang; Adriana Zingone; Louis M Staudt
Control of autophagic cell death by caspase-10 in multiple myeloma.
Cancer cell 2013;23(4):435-49.
2013: Michael J Kruhlak
Correlative fluorescence and EFTEM imaging of the organized components of the mammalian nucleus.
Methods in molecular biology (Clifton, N.J.) 2013;950():397-416.
2013: Alioscka A Sousa; Michael J Kruhlak
Introduction: nanoimaging techniques in biology.
Methods in molecular biology (Clifton, N.J.) 2013;950():1-10.
2013: Maria J Massimelli; Michael J Kruhlak; Vladimir Majerciak; Zhi-Ming Zheng
Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA.
Journal of virology 2013;87(1):243-56.
2012: Jürgen R Müller; Thomas A Waldmann; Michael J Kruhlak; Sigrid Dubois
Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cells.
The Journal of biological chemistry 2012;287(48):40328-38.
2012: Alioscka A Sousa; Guofeng Zhang; Jeffrey T Morgan; Christopher J Ackerson; April Adams; Patrick H Brown; M P Suresh Jayasekara; Michael J Kruhlak; Richard Leapman
Synthesis, characterization, and direct intracellular imaging of ultrasmall and uniform glutathione-coated gold nanoparticles.
Small (Weinheim an der Bergstrasse, Germany) 2012;8(14):2277-86.
2012: Xuguang Tai; Craig B Thompson; François Van Laethem; Anthony Adams; Lionel Feigenbaum; Larry Granger; Terry I Guinter; Michael J Kruhlak; Tullia Lindsten; Leonid Pobezinsky; Susan O Sharrow; Alfred Singer
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
Blood 2012;119(22):5155-63.
2012: Khadija Ben-Aissa; Jian-Jiang Hao; Jay R Knutson; Michael J Kruhlak; Ofelia Maniti; Genaro Patino-Lopez; Catherine PICART; Tilman Rosales; Natalya V Belkina; Stephen Shaw
Activation of moesin, a protein that links actin cytoskeleton to the plasma membrane, occurs by phosphatidylinositol 4,5-bisphosphate (PIP2) binding sequentially to two sites and releasing an autoinhibitory linker.
The Journal of biological chemistry 2012;287(20):16311-23.
2012: Harald F Langer; Elin Lehrmann; Xuri Li; Sven G Meuth; Bernhard Nieswandt; Hongchang Qu; John W Rose; Rebecca Schleicher; Daniel I Simon; Zhongshu Tang; Yunmei Wang; Connie Wong; Yongqing Zhang; Hong Zhou; Khalil Bdeir; Kevin G Becker; Sumeena Bhatia; James B Burns; Antonios Chatzigeorgiou; Eun Young Choi; Kyoung-Jin Chung; Kerstin Göbel; Kenneth E Hill; Michael J Kruhlak; Paul Kubes; John D Lambris; Triantafyllos Chavakis
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis.
Circulation research 2012;110(9):1202-10.
2012: Anke S Lonsdorf; Sven G Meuth; Bernhard Nieswandt; Sabine Ring; Stefan W Schneider; Tanja Schönberger; Alexander H Enk; Manuela Fahrleitner; Meinrad Gawaz; Sarah Gehring; Stephan Gnerlich; Björn F Krämer; Michael J Kruhlak; Harald F Langer
Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis.
The Journal of biological chemistry 2012;287(3):2168-78.
2012: Yin Liu; Scott M Loughhead; Raj Nambiar; Chung Park; Genaro Patino-Lopez; Hai Qi; Natalya V Belkina; Khadija Ben-Aissa; Jian-Jiang Hao; John H Kehrl; Michael J Kruhlak; Matthew J Tyska; Ulrich H von Andrian; Stephen Shaw
Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice.
Blood 2012;119(2):445-53.
2011: Ju-Gyeong Kang; Michael J Kruhlak; Vladimir Majerciak; Thomas Uldrick; Xiaohong Wang; Robert Yarchoan; Zhi-Ming Zheng
Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation.
The Journal of pathology 2011;225(3):378-89.
2011: Ju-Gyeong Kang; Natalia Pripuzova; Vladimir Majerciak; Michael J Kruhlak; Shu-Yun Le; Zhi-Ming Zheng
Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression.
Journal of virology 2011;85(6):2620-30.
2011: Vladimir Majerciak; Hiroaki Uranishi; Michael J Kruhlak; Guy R Pilkington; Maria Julia Massimelli; Jenifer Bear; George N Pavlakis; Barbara K Felber; Zhi-Ming Zheng
Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59.
Journal of virology 2011;85(4):1528-40.
2010: Harald F Langer; Xuri Li; Paola Magotti; Valeria V Orlova; Stavros Rafail; Paul A Roche; Eun Young Choi; Kyoung-Jin Chung; Robert A DeAngelis; Matina Economopoulou; Sunil Kaul; Michael J Kruhlak; John D Lambris; Markella Alatsatianos; Triantafyllos Chavakis
Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis.
Blood 2010;116(22):4395-403.
2010: Aspasia Katragkou; Michael J Kruhlak; Maria Simitsopoulou; Athanasios Chatzimoschou; Anna Taparkou; Catherine J Cotten; Fotini Paliogianni; Eudoxia Diza-Mataftsi; Chaido Tsantali; THOMAS WALSH; Emmanuel Roilides
Interactions between human phagocytes and Candida albicans biofilms alone and in combination with antifungal agents.
The Journal of infectious diseases 2010;201(12):1941-9.
2010: Genaro Patino-Lopez; L Aravind; Xiaoyun Dong; Michael J Kruhlak; E Michael Ostap; Stephen Shaw
Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH).
The Journal of biological chemistry 2010;285(12):8675-86.
2009: Elsa Callén; Sam Bunting; Ching-Yu Huang; Michael J Difilippantonio; Nancy Wong; Bernard Khor; Grace Mahowald; Michael J Kruhlak; Thomas Ried; Barry P Sleckman; André Nussenzweig
Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG.
Cell cycle (Georgetown, Tex.) 2009;8(15):2408-12.
2009: Jian-Jiang Hao; Yin Liu; Michael J Kruhlak; Karen E Debell; Barbara L Rellahan; Stephen Shaw
Phospholipase C-mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane.
The Journal of cell biology 2009;184(3):451-62.
2009: Michael J Kruhlak; Arkady Celeste; André Nussenzweig
Monitoring DNA breaks in optically highlighted chromatin in living cells by laser scanning confocal microscopy.
Methods in molecular biology (Clifton, N.J.) 2009;523():125-40.
2009: Rong Jia; Xuefeng Liu; Mingfang Tao; Michael J Kruhlak; Ming Guo; Craig Meyers; Carl Baker; Zhi-Ming Zheng
Control of the papillomavirus early-to-late switch by differentially expressed SRp20.
Journal of virology 2009;83(1):167-80.
2008: Simone Difilippantonio; Eric Gapud; Nancy Wong; Ching-Yu Huang; Grace Mahowald; Hua-Tang Chen; Michael J Kruhlak; Elsa Callen; Ferenc Livak; Michel C Nussenzweig; Barry P Sleckman; André Nussenzweig
53BP1 facilitates long-range DNA end-joining during V(D)J recombination.
Nature 2008;456(7221):529-33.
2008: Genaro Patino-Lopez; Xiaoyun Dong; Khadija Ben-Aissa; Kelsie M Bernot; Takashi Itoh; Mitsunori Fukuda; Michael J Kruhlak; Lawrence E Samelson; Stephen Shaw
Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.
The Journal of biological chemistry 2008;283(26):18323-30.
2008: Vladimir Majerciak; Koji Yamanegi; eric Allemand; Michael J Kruhlak; Adrian R Krainer; Zhi-Ming Zheng
Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing.
Journal of virology 2008;82(6):2792-801.
2007: Yin Liu; Michael J Kruhlak; Jian-Jiang Hao; Stephen Shaw
Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity.
Journal of leukocyte biology 2007;82(3):742-51.
2007: Jung-Ae Kim; Michael J Kruhlak; Farokh Dotiwala; André Nussenzweig; James E Haber
Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals.
The Journal of cell biology 2007;178(2):209-18.
2007: Michael J Kruhlak; Elizabeth E Crouch; Marika Orlov; Carolina Montaño; Stanislaw A Gorski; André Nussenzweig; Tom Misteli; Robert Phair; Rafael Casellas
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
Nature 2007;447(7145):730-4.
2007: Simone Difilippantonio; Arkady Celeste; Michael J Kruhlak; youngsoo Lee; Michael J Difilippantonio; Lionel Feigenbaum; Stephen P Jackson; Peter J McKinnon; André Nussenzweig
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis.
The Journal of experimental medicine 2007;204(5):1003-11.
2007: William W Hope; Michael J Kruhlak; Caron A Lyman; Ruta Petraitiene; Vidmantas Petraitis; Andrea Francesconi; Miki Kasai; Diana Mickiene; Tin Sein; Joanne Peter; Amy M Kelaher; Johanna E Hughes; Margaret P Cotton; Catherine J Cotten; John Bacher; Sanjay Tripathi; Louis Bermudez; Timothy K Maugel; Patricia M Zerfas; John R Wingard; George L Drusano; THOMAS WALSH
Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapy.
The Journal of infectious diseases 2007;195(3):455-66.
2007: Oran Kwon; Peter Eck; Shenglin Chen; Christopher P Corpe; Je-Hyuk Lee; Michael J Kruhlak; Mark Levine
Inhibition of the intestinal glucose transporter GLUT2 by flavonoids.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(2):366-77.
2006: Michael J Kruhlak; Arkady Celeste; André Nussenzweig
Spatio-temporal dynamics of chromatin containing DNA breaks.
Cell cycle (Georgetown, Tex.) 2006;5(17):1910-2.
2006: Jean-Philippe Herbeuval; Jakob Nilsson; Adriano Boasso; Andrew W Hardy; Michael J Kruhlak; Stephanie A Anderson; Matthew J Dolan; Michel Dy; Jan Andersson; Gene M Shearer
Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):7000-5.
2006: Michael J Kruhlak; Arkady Celeste; Graham Dellaire; Oscar Fernandez-Capetillo; Waltraud G Müller; James G McNally; David P Bazett-Jones; André Nussenzweig
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks.
The Journal of cell biology 2006;172(6):823-34.
2005: KAKALI SARKAR; Michael J Kruhlak; Stanley L Erlandsen; Stephen Shaw
Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells.
Immunology 2005;116(4):513-24.
2005: Caroline S Kim; Vasily Vasko; Yasuhito Kato; Michael J Kruhlak; Motoyasu Saji; Sheue-Yann Cheng; Matthew D Ringel
AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma.
Endocrinology 2005;146(10):4456-63.
2005: Simone Difilippantonio; Arkady Celeste; Oscar Fernandez-Capetillo; Hua-Tang Chen; Bernardo Reina-San-Martin; François Van Laethem; Yong-Ping Yang; Galina V Petukhova; Michael Eckhaus; Lionel Feigenbaum; Katia Manova-Todorova; Michael J Kruhlak; R Daniel Camerini-Otero; Shyam Sharan; Michel C Nussenzweig; André Nussenzweig
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.
Nature cell biology 2005;7(7):675-85.
2004: Ruchika Nijhara; Paula B van Hennik; Michelle Gignac; Michael J Kruhlak; Peter L Hordijk; Jerome Delon; Stephen Shaw
Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):4985-93.
2004: Cynthia A Leifer; Margaret N Kennedy; Alessandra Mazzoni; ChangWoo Lee; Michael J Kruhlak; David M Segal
TLR9 is localized in the endoplasmic reticulum prior to stimulation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1179-83.
2004: Vasily Vasko; Motoyasu Saji; E Hardy; Michael J Kruhlak; Alexandr Larin; Victoria Savchenko; M Miyakawa; Osamu Isozaki; H Murakami; T Tsushima; Kenneth D Burman; Catherine De Micco; Matthew D Ringel
Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer.
Journal of medical genetics 2004;41(3):161-70.
2003: Mingfang Tao; Michael J Kruhlak; Shuhua Xia; Elliot J Androphy; Zhi-Ming Zheng
Signals that dictate nuclear localization of human papillomavirus type 16 oncoprotein E6 in living cells.
Journal of virology 2003;77(24):13232-47.
2003: Martin J Brown; Ruchika Nijhara; John A Hallam; Michelle Gignac; Kenneth M Yamada; Stanley L Erlandsen; Jerome Delon; Michael J Kruhlak; Stephen Shaw
Chemokine stimulation of human peripheral blood T lymphocytes induces rapid dephosphorylation of ERM proteins, which facilitates loss of microvilli and polarization.
Blood 2003;102(12):3890-9.
2003: Niti Puri; Michael J Kruhlak; Sidney W Whiteheart; Paul A Roche
Mast cell degranulation requires N-ethylmaleimide-sensitive factor-mediated SNARE disassembly.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5345-52.
2003: Arkady Celeste; Oscar Fernandez-Capetillo; Michael J Kruhlak; Duane R Pilch; David W Staudt; Alicia Lee; Robert F Bonner; William M Bonner; André Nussenzweig
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.
Nature cell biology 2003;5(7):675-9.
2003: Ying Ren; Michael J Kruhlak; David P Bazett-Jones
Same serial section correlative light and energy-filtered transmission electron microscopy.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003;51(5):605-12.
2001: Michael J Kruhlak; Michael Hendzel; Wolfgang Fischle; Nicholas Bertos; S Hameed; Xiang-Jiao Yang; Eric Verdin; David P Bazett-Jones
Regulation of global acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin.
The Journal of biological chemistry 2001;276(41):38307-19.
2001: François-Michel Boisvert; Michael J Kruhlak; A K Box; Michael Hendzel; David P Bazett-Jones
The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body.
The Journal of cell biology 2001;152(5):1099-106.
2001: Michael Hendzel; Michael J Kruhlak; N A MacLean; François-Michel Boisvert; Melody A Lever; David P Bazett-Jones
Compartmentalization of regulatory proteins in the cell nucleus.
The Journal of steroid biochemistry and molecular biology 2001;76(1-5):9-21.
2000: Audrey H Wang; Michael J Kruhlak; J Wu; Nicholas Bertos; M Vezmar; Barry Posner; David P Bazett-Jones; Xiang-Jiao Yang
Regulation of histone deacetylase 4 by binding of 14-3-3 proteins.
Molecular and cellular biology 2000;20(18):6904-12.
2000: Michael J Kruhlak; M A Lever; Wolfgang Fischle; Eric Verdin; David P Bazett-Jones; Michael Hendzel
Reduced mobility of the alternate splicing factor (ASF) through the nucleoplasm and steady state speckle compartments.
The Journal of cell biology 2000;150(1):41-51.
2000: CA Spencer; Michael J Kruhlak; H L Jenkins; Xuejun Sun; David P Bazett-Jones
Mitotic transcription repression in vivo in the absence of nucleosomal chromatin condensation.
The Journal of cell biology 2000;150(1):13-26.
1999: David P Bazett-Jones; Michael Hendzel; Michael J Kruhlak
Stoichiometric analysis of protein- and nucleic acid-based structures in the cell nucleus.
Micron (Oxford, England : 1993) 1999;30(2):151-7.
1998: Michael Hendzel; Michael J Kruhlak; David P Bazett-Jones
Organization of highly acetylated chromatin around sites of heterogeneous nuclear RNA accumulation.
Molecular biology of the cell 1998;9(9):2491-507.