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Nicholas Ktistakis

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TOP 3
Nicholas T Ktistakis; Sharon A Tooze
PIPing on lysosome tubes.
Nicholas T Ktistakis; Maria Manifava; Priya Schoenfelder; Sergio Rotondo
How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal.
Eleanor M Cottam; Wilhelm Gerner; Nicholas T Ktistakis; Helena J Maier; Maria Manifava; Laura C Vaux; Paul Britton; Priya Chandra-Schoenfelder; Thomas Wileman
Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate.

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All Publications

2013: Nicholas T Ktistakis; Sharon A Tooze
PIPing on lysosome tubes.
The EMBO journal 2013;32(3):315-7.
2012: Nicholas T Ktistakis; Maria Manifava; Priya Schoenfelder; Sergio Rotondo
How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal.
Biochemical Society transactions 2012;40(1):37-43.
2011: Eleanor M Cottam; Wilhelm Gerner; Nicholas T Ktistakis; Helena J Maier; Maria Manifava; Laura C Vaux; Paul Britton; Priya Chandra-Schoenfelder; Thomas Wileman
Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate.
Autophagy 2011;7(11):1335-47.
2011: Ju Huang; Cheryl L Birmingham; Shahab Shahnazari; Jessica Shiu; Yiyu T Zheng; Adam C Smith; Kenneth G Campellone; Won Do Heo; Samantha Gruenheid; Tobias Meyer; Matthew D Welch; Nicholas T Ktistakis; Peter Kijun Kim; Daniel J Klionsky; John H Brumell
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.
Autophagy 2011;7(1):17-26.
2011: Nicholas T Ktistakis; Simon Andrews; Joshua Long
What is the advantage of a transient precursor in autophagosome biogenesis?
Autophagy 2011;7(1):118-22.
2010: Chloe Burman; Nicholas T Ktistakis
Autophagosome formation in mammalian cells.
Seminars in immunopathology 2010;32(4):397-413.
2010: Kohichi Matsunaga; Eiji Morita; Tatsuya Saitoh; Shizuo Akira; Nicholas T Ktistakis; Tetsuro Izumi; takeshi noda; Tamotsu Yoshimori
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.
The Journal of cell biology 2010;190(4):511-21.
2010: Chloe Burman; Nicholas T Ktistakis
Regulation of autophagy by phosphatidylinositol 3-phosphate.
FEBS letters 2010;584(7):1302-12.
2010: Naoko Taguchi-Atarashi; Maho Hamasaki; Kohichi Matsunaga; Hiroko Omori; Nicholas T Ktistakis; Tamotsu Yoshimori; takeshi noda
Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy.
Traffic (Copenhagen, Denmark) 2010;11(4):468-78.
2010: Stuart Conway; James Gardiner; Simon J A Grove; Melloney K Johns; Ze-Yi Lim; GF Painter; Diane E J E Robinson; Christine Schieber; Jan W Thuring; Leon S-M Wong; Meng-Xin Yin; Antony W Burgess; Bruno Catimel; Phillip T Hawkins; Nicholas T Ktistakis; Len R Stephens; Andrew B Holmes
Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes.
Organic & biomolecular chemistry 2010;8(1):66-76.
2010: Nicholas T Ktistakis
Lipid signaling and homeostasis: PA- is better than PA-H, but what about those PIPs?
Science signaling 2010;3(151):pe46.
2009: Padinjat Raghu; Maria Manifava; John Coadwell; Nicholas T Ktistakis
Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors).
Biochimica et biophysica acta 2009;1791(9):889-97.
2009: Michael ter Braak; Kerstin Danneberg; Karin Lichte; Kerstin Liphardt; Nicholas T Ktistakis; Stuart M Pitson; Timothy Hla; Karl H Jakobs; Dagmar Meyer Zu Heringdorf
Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors.
Biochimica et biophysica acta 2009;1791(5):357-70.
2009: Laura Gillies; Sue Chin Lee; Jaclyn S Long; Nicholas T Ktistakis; Nigel J Pyne; Susan Pyne
The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division.
Cellular signalling 2009;21(5):675-84.
2009: Padinjat Raghu; Elise Coessens; Maria Manifava; Plamen Georgiev; Trevor R Pettitt; Eleanor Wood; Isaac Garcia-Murillas; hanneke okkenhaug; Deepti Trivedi; Qifeng Zhang; Azam Razzaq; Ola Zaid; Michael Wakelam; Cahir J O'Kane; Nicholas T Ktistakis
Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels.
The Journal of cell biology 2009;185(1):129-45.
2008: Simon Walker; Priya Chandra; Maria Manifava; Elizabeth Axe; Nicholas T Ktistakis
Making autophagosomes: localized synthesis of phosphatidylinositol 3-phosphate holds the clue.
Autophagy 2008;4(8):1093-6.
2008: Elizabeth L Axe; Simon A Walker; Maria Manifava; Priya Chandra; H Llewelyn Roderick; Anja Habermann; Gareth Griffiths; Nicholas T Ktistakis
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum.
The Journal of cell biology 2008;182(4):685-701.
2008: Catherine Stace; Maria Manifava; Christine Delon; John Coadwell; Shamshad Cockcroft; Nicholas T Ktistakis
PA binding of phosphatidylinositol 4-phosphate 5-kinase.
Advances in enzyme regulation 2008;48():55-72.
2006: Catherine L Stace; Nicholas T Ktistakis
Phosphatidic acid- and phosphatidylserine-binding proteins.
Biochimica et biophysica acta 2006;1761(8):913-26.
2006: Christine E Edmead; Bridget C Fox; Catherine Stace; Nicholas T Ktistakis; Melanie J Welham
The pleckstrin homology domain of Gab-2 is required for optimal interleukin-3 signalsome-mediated responses.
Cellular signalling 2006;18(8):1147-55.
2006: Matthias Corrotte; Sylvette Chasserot-Golaz; Ping Huang; Guangwei Du; Nicholas T Ktistakis; Michael A Frohman; Nicolas Vitale; Marie-France Bader; Nancy J Grant
Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis.
Traffic (Copenhagen, Denmark) 2006;7(3):365-77.
2005: Susan Pyne; Jaclyn S Long; Nicholas T Ktistakis; Nigel J Pyne
Lipid phosphate phosphatases and lipid phosphate signalling.
Biochemical Society transactions 2005;33(Pt 6):1370-4.
2005: Jaclyn Long; Peter I Darroch; Kah Fei Wan; Kok-Choi Kong; Nicholas T Ktistakis; Nigel J Pyne; Susan Pyne
Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools.
The Biochemical journal 2005;391(Pt 1):25-32.
2004: Christine Delon; Maria Manifava; Eleanor Wood; Dawn Thompson; Sonja Krugmann; Susan Pyne; Nicholas T Ktistakis
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
The Journal of biological chemistry 2004;279(43):44763-74.
2004: Christa Testerink; Henk L Dekker; Ze-Yi Lim; Melloney K Johns; Andrew B Holmes; Chris G Koster; Nicholas T Ktistakis; Teun Munnik
Isolation and identification of phosphatidic acid targets from plants.
The Plant journal : for cell and molecular biology 2004;39(4):527-36.
2004: Karen A Cadwallader; Mohib Uddin; Alison M Condliffe; Andrew S Cowburn; Jessica F White; Jeremy N Skepper; Nicholas T Ktistakis; Edwin R Chilvers
Effect of priming on activation and localization of phospholipase D-1 in human neutrophils.
European journal of biochemistry / FEBS 2004;271(13):2755-64.
2004: Christopher J R Loewen; Maria L Gaspar; Stephen A Jesch; Christine Delon; Nicholas T Ktistakis; Susan A Henry; Timothy P Levine
Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid.
Science (New York, N.Y.) 2004;304(5677):1644-7.
2003: Nicholas T Ktistakis; Christine Delon; Maria Manifava; E Wood; I Ganley; Jane M Sugars
Phospholipase D1 and potential targets of its hydrolysis product, phosphatidic acid.
Biochemical Society transactions 2003;31(Pt 1):94-7.
2002: Jane M Sugars; Selim Cellek; Maria Manifava; John Coadwell; Nicholas T Ktistakis
Hierarchy of membrane-targeting signals of phospholipase D1 involving lipid modification of a pleckstrin homology domain.
The Journal of biological chemistry 2002;277(32):29152-61.
2002: Sonja Krugmann; Karen E Anderson; SH Ridley; N Risso; Alex McGregor; John Coadwell; Keith Davidson; Alicia Eguinoa; Chris D Ellson; Peter Lipp; Maria Manifava; Nicholas T Ktistakis; GF Painter; Jan W Thuring; Matthew A Cooper; Ze-Yi Lim; Andrew B Holmes; Stephen K Dove; Robert H Michell; A Grewal; A Nazarian; Hediye Erdjument-Bromage; Paul Tempst; Len R Stephens; Phillip T Hawkins
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.
Molecular cell 2002;9(1):95-108.
2001: SH Ridley; Nicholas T Ktistakis; Keith Davidson; Karen E Anderson; Maria Manifava; Chris D Ellson; Peter Lipp; Martin D Bootman; John Coadwell; A Nazarian; Hediye Erdjument-Bromage; Paul Tempst; Matthew A Cooper; Jan W Thuring; Ze-Yi Lim; Andrew B Holmes; Len R Stephens; Phillip T Hawkins
FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments.
Journal of cell science 2001;114(Pt 22):3991-4000.
2001: John M Lucocq; Maria Manifava; K Bi; Michael Roth; Nicholas T Ktistakis
Immunolocalisation of phospholipase D1 on tubular vesicular membranes of endocytic and secretory origin.
European journal of cell biology 2001;80(8):508-20.
2001: Maria Manifava; Jan W Thuring; Ze-Yi Lim; Len C Packman; Andrew B Holmes; Nicholas T Ktistakis
Differential binding of traffic-related proteins to phosphatidic acid- or phosphatidylinositol (4,5)- bisphosphate-coupled affinity reagents.
The Journal of biological chemistry 2001;276(12):8987-94.
2001: I G Ganley; Stephanie J. Walker; Maria Manifava; D Li; H Alex Brown; Nicholas T Ktistakis
Interaction of phospholipase D1 with a casein-kinase-2-like serine kinase.
The Biochemical journal 2001;354(Pt 2):369-78.
2001: Shamshad Cockcroft; K Bi; Nicholas T Ktistakis; Michael Roth
Biological properties and measurement of phospholipase D activation by ADP-ribosylation factor (ARF).
Methods in enzymology 2001;329():355-72.
1999: Jane M Sugars; Selim Cellek; Maria Manifava; John Coadwell; Nicholas T Ktistakis
Fatty acylation of phospholipase D1 on cysteine residues 240 and 241 determines localization on intracellular membranes.
The Journal of biological chemistry 1999;274(42):30023-7.
1999: Nicholas T Ktistakis; Maria Manifava; Jane M Sugars; K Bi; Michael Roth
Cellular expression and function of phospholipase D1.
Biochemical Society transactions 1999;27(4):634-7.
1999: Michael Roth; K Bi; Nicholas T Ktistakis; S Yu
Phospholipase D as an effector for ADP-ribosylation factor in the regulation of vesicular traffic.
Chemistry and physics of lipids 1999;98(1-2):141-52.
1999: Maria Manifava; Jane M Sugars; Nicholas T Ktistakis
Modification of catalytically active phospholipase D1 with fatty acid in vivo.
The Journal of biological chemistry 1999;274(2):1072-7.
1998: Nicholas T Ktistakis
Signalling molecules and the regulation of intracellular transport.
BioEssays : news and reviews in molecular, cellular and developmental biology 1998;20(6):495-504.
1997: K Bi; Michael Roth; Nicholas T Ktistakis
Phosphatidic acid formation by phospholipase D is required for transport from the endoplasmic reticulum to the Golgi complex.
Current biology : CB 1997;7(5):301-7.
1996: Nicholas T Ktistakis; H A Brown; M G Waters; Paul C Sternweis; Michael Roth
Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.
The Journal of cell biology 1996;134(2):295-306.
1995: Nicholas T Ktistakis; H A Brown; Paul C Sternweis; Michael Roth
Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4952-6.
1995: Nicholas T Ktistakis; C Y Kao; R H Wang; Michael Roth
A fluorescent lipid analogue can be used to monitor secretory activity and for isolation of mammalian secretion mutants.
Molecular biology of the cell 1995;6(2):135-50.
1992: Hassan Y Naim; B Amarneh; Nicholas T Ktistakis; Michael Roth
Effects of altering palmitylation sites on biosynthesis and function of the influenza virus hemagglutinin.
Journal of virology 1992;66(12):7585-8.
1992: Nicholas T Ktistakis; Maurine E Linder; Michael Roth
Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein.
Nature 1992;356(6367):344-6.
1991: Nicholas T Ktistakis; Michael Roth; George S Bloom
PtK1 cells contain a nondiffusible, dominant factor that makes the Golgi apparatus resistant to brefeldin A.
The Journal of cell biology 1991;113(5):1009-23.
1990: Nicholas T Ktistakis; D Thomas; Michael Roth
Characteristics of the tyrosine recognition signal for internalization of transmembrane surface glycoproteins.
The Journal of cell biology 1990;111(4):1393-407.
1990: J Lazarovits; S P Shia; Nicholas T Ktistakis; M S Lee; C Bird; Michael Roth
The effects of foreign transmembrane domains on the biosynthesis of the influenza virus hemagglutinin.
The Journal of biological chemistry 1990;265(8):4760-7.
1988: Nicholas T Ktistakis; C Y Kao; D Lang
In vitro assembly of the outer shell of bacteriophage phi 6 nucleocapsid.
Virology 1988;166(1):91-102.
1987: D Lang; henry steely; C Y Kao; Nicholas T Ktistakis
Length, mass, and denaturation of double-stranded RNA molecules compared with DNA.
Biochimica et biophysica acta 1987;910(3):271-81.