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Hung-Hai Ku

Research Profile

Anatomy

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Reverse Transcriptase Polymerase Chain Reaction

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Medulloblastoma

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Yun-Chien Tseng; Min-Chieh Yang; Chin-Wen Chi; Rong-Hong Hsieh; Kai-Wen Hsu; Kuo-Hung Huang; Hung-Hai Ku; Anna Fen-Yau Li; Yu-Hui Tsai; Min-Jen Tseng; Tien-Shun Yeh
Notch2-induced COX-2 expression enhancing gastric cancer progression.
Yuh-Lih Chang; Liang-Kung Chen; Shih-Jen Chen; Yu-Chih Chen; Yi-Jen Chen; Dah-Ching Ding; Chuan-Chih Hsu; Shih-Chieh Hung; Chung-Lan Kao; Hung-Hai Ku; Kun-Hsiung Lee; Hsin-Yang Li; Chin-Po Lin; Jhi-Joung Wang; Cheng-Chia Yu; Shih-Hwa Chiou
Docosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with Parkinson-like pathology.
Shih-Hwa Chiou; Shih-Jen Chen; Yuh-Lih Chang; Yu-Chih Chen; Hsin-Yang Li; Dow-Tien Chen; Hsin-Hui Wang; Chia-Ming Chang; Yi-Jen Chen; Hung-Hai Ku
MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin+ cells.

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All Publications

2012: Yun-Chien Tseng; Min-Chieh Yang; Chin-Wen Chi; Rong-Hong Hsieh; Kai-Wen Hsu; Kuo-Hung Huang; Hung-Hai Ku; Anna Fen-Yau Li; Yu-Hui Tsai; Min-Jen Tseng; Tien-Shun Yeh
Notch2-induced COX-2 expression enhancing gastric cancer progression.
Molecular carcinogenesis 2012;51(12):939-51.
2012: Yuh-Lih Chang; Liang-Kung Chen; Shih-Jen Chen; Yu-Chih Chen; Yi-Jen Chen; Dah-Ching Ding; Chuan-Chih Hsu; Shih-Chieh Hung; Chung-Lan Kao; Hung-Hai Ku; Kun-Hsiung Lee; Hsin-Yang Li; Chin-Po Lin; Jhi-Joung Wang; Cheng-Chia Yu; Shih-Hwa Chiou
Docosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with Parkinson-like pathology.
Cell transplantation 2012;21(1):313-32.
2011: Shih-Hwa Chiou; Shih-Jen Chen; Yuh-Lih Chang; Yu-Chih Chen; Hsin-Yang Li; Dow-Tien Chen; Hsin-Hui Wang; Chia-Ming Chang; Yi-Jen Chen; Hung-Hai Ku
MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin+ cells.
Journal of cellular and molecular medicine 2011;15(3):612-24.
2011: Pin-I Huang; Chi-Chang Juan; Hung-Hai Ku; Hsin-Chen Lee; Shih-Tien Wang; Li-Hsin Chen; Liang-Kung Chen; Yu-Chih Chen; Chin-Wen Chi; Guang-Yuh Chiou; Shih-Hwa Chiou; Chuan-Chih Hsu; Chung-Lan Kao
PGC-1α mediates differentiation of mesenchymal stem cells to brown adipose cells.
Journal of atherosclerosis and thrombosis 2011;18(11):966-80.
2010: Hsin-Yang Li; Yi-Jen Chen; Shih-Jen Chen; Chung-Lan Kao; Ling-Ming Tseng; Wen-Liang Lo; Chia-Ming Chang; Der-Ming Yang; Hung-Hai Ku; nae-fang twu; Chen-Yi Liao; Shih-Hwa Chiou; Yuh-Lih Chang
Induction of insulin-producing cells derived from endometrial mesenchymal stem-like cells.
The Journal of pharmacology and experimental therapeutics 2010;335(3):817-29.
2010: Shih-Jen Chen; Chia-Ming Chang; Shen-Kou Tsai; Yuh-Lih Chang; Shih-Jie Chou; Shiang-Suo Huang; Lung-Kuo Tai; Yu-Chih Chen; Hung-Hai Ku; Hsin-Yang Li; Shih-Hwa Chiou
Functional improvement of focal cerebral ischemia injury by subdural transplantation of induced pluripotent stem cells with fibrin glue.
Stem cells and development 2010;19(11):1757-67.
2010: Chung-Lan Kao; Liang-Kung Chen; Yuh-Lih Chang; Ming-Chih Yung; Chuan-Chih Hsu; Yu-Chih Chen; Wen-Liang Lo; Shih-Jen Chen; Hung-Hai Ku; Shin-Jang Hwang
Resveratrol protects human endothelium from H(2)O(2)-induced oxidative stress and senescence via SirT1 activation.
Journal of atherosclerosis and thrombosis 2010;17(9):970-9.
2010: Cheng-Chia Yu; Guang-Yuh Chiou; Yi-Yen Lee; Yuh-Lih Chang; Pin-I Huang; Yi-Wei Cheng; Lung-Kuo Tai; Hung-Hai Ku; Shih-Hwa Chiou; Tai-Tong Wong
Medulloblastoma-derived tumor stem-like cells acquired resistance to TRAIL-induced apoptosis and radiosensitivity.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2010;26(7):897-904.
2010: Chung-Lan Kao; Lung-Kuo Tai; Shih-Hwa Chiou; Yi-Jen Chen; Kung-Hsiung Lee; Shih-Jie Chou; Yuh-Lih Chang; Chia-Ming Chang; Shih-Jen Chen; Hung-Hai Ku; Hsin-Yang Li
Resveratrol promotes osteogenic differentiation and protects against dexamethasone damage in murine induced pluripotent stem cells.
Stem cells and development 2010;19(2):247-58.
2010: Li-Hsin Chen; Kun-Ling Tsai; Yi-Wei Chen; Cheng-Chia Yu; Kuo-Wei Chang; Shih-Hwa Chiou; Hung-Hai Ku; Pen-Yuan Chu; Ling-Ming Tseng; Pin-I Huang; Wen-Liang Lo
MicroRNA as a Novel Modulator in Head and Neck Squamous Carcinoma.
Journal of oncology 2010;2010():135632.
2009: Yu-Chih Chen; Yi-Wei Chen; Han-Shui Hsu; Ling-Ming Tseng; Pin-I Huang; Kai-Hsi Lu; Dow-Tien Chen; Lung-Kuo Tai; Ming-Chi Yung; Shih-Ching Chang; Hung-Hai Ku; Shih-Hwa Chiou; Wen-Liang Lo
Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer.
Biochemical and biophysical research communications 2009;385(3):307-13.
2009: Kai-Hsi Lu; Yi-Wei Chen; Ping-Hsing Tsai; Ming-Long Tsai; Yi-Yen Lee; Chih-Yao Chiang; Chung-Lan Kao; Shih-Hwa Chiou; Hung-Hai Ku; Chi-Hung Lin; Yann-Jang Chen
Evaluation of radiotherapy effect in resveratrol-treated medulloblastoma cancer stem-like cells.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2009;25(5):543-50.
2009: An-Ming Wang; Hung-Hai Ku; Yu-Chih Liang; Yen-Chou Chen; Yuh-Ming Hwu; Tien-Shun Yeh
The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells.
Journal of cellular biochemistry 2009;106(4):682-92.
2008: Yi-Yen Lee; Chung-Lan Kao; Ping-Hsing Tsai; Tung-Hu Tsai; Shih-Hwa Chiou; Wei-Fong Wu; Hung-Hai Ku; Tai-Tong Wong
Caffeic acid phenethyl ester preferentially enhanced radiosensitizing and increased oxidative stress in medulloblastoma cell line.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2008;24(9):987-94.
2008: Shih-Hwa Chiou; Cheng-Chia Yu; Chi-Yang Huang; Shu-Chun Lin; Chung-Ji Liu; Tung-Hu Tsai; Shiu-Huey Chou; Chian-Shiu Chien; Hung-Hai Ku; Jeng-Fan Lo
Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(13):4085-95.
2008: Cherng-Kang Perng; Chung-Lan Kao; Yi-Ping Yang; Han-Tso Lin; Wen-Bin Lin; Yue-Ru Chu; Hsiao-Jung Wang; Hsu Ma; Hung-Hai Ku; Shih-Hwa Chiou
Culturing adult human bone marrow stem cells on gelatin scaffold with pNIPAAm as transplanted grafts for skin regeneration.
Journal of biomedical materials research. Part A 2008;84(3):622-30.
2008: Chi-Hsien Peng; Shih-Hwa Chiou; Shih-Jen Chen; Yueh-Ching Chou; Hung-Hai Ku; Cheng-Kuo Cheng; Chih-Ju Yen; Tung-Hu Tsai; Yuh-Lih Chang; Chun-Lan Kao
Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2008;18(2):128-40.
2008: Yu-Chih Chen; Han-Shui Hsu; Yi-Wei Chen; Tung-Hu Tsai; Chorng-Kuang How; Chien-Ying Wang; Shih-Chieh Hung; Yuh-Lih Chang; Ming-Long Tsai; Yi-Yen Lee; Hung-Hai Ku; Shih-Hwa Chiou
Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells.
PloS one 2008;3(7):e2637.
2008: Shih-Hwa Chiou; Chung-Lan Kao; Yi-Wei Chen; Chien-Shu Chien; Shih-Chieh Hung; Jeng-Fan Lo; Yann-Jang Chen; Hung-Hai Ku; Ming-Ta Hsu; Tai-Tong Wong
Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor.
PloS one 2008;3(5):e2090.
2007: Chung-Lan Kao; Han-Tso Lin; Yi-Wei Chen; Ying-Chou Chen; Fu-Ting Tsai; Y-L Chang; Shih-Hwa Chiou; Dey-Chyi Sheu; Hung-Hai Ku
Fibronectin suppresses lipopolysaccharide-induced liver damage and promotes the cytoprotection abilities of hepatocyte-like cells derived from human bone marrow mesenchymal stem cells.
Transplantation proceedings 2007;39(10):3444-5.
2007: Heng-Liang Lin; Muh-Hwa Yang; Cheng-Wen Wu; Po-Min Chen; Yi-Ping Yang; Yue-Ru Chu; Chung-Lan Kao; Hung-Hai Ku; Jen-Fan Lo; Jing-Ping Liou; Chin-Wen Chi; Shih-Hwa Chiou
2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer.
International journal of cancer. Journal international du cancer 2007;121(11):2547-55.
2007: Chia-Ming Chang; Chung-Lan Kao; Yuh-Lih Chang; Ming-Jie Yang; Yu-Chih Chen; Bi-Lin Sung; Tung-Hu Tsai; Kuan-Chong Chao; Shih-Hwa Chiou; Hung-Hai Ku
Placenta-derived multipotent stem cells induced to differentiate into insulin-positive cells.
Biochemical and biophysical research communications 2007;357(2):414-20.
2007: Shing-Jong Lin; Yung-Hsiang Chen; Feng-Yen Lin; Li-Yuan Hsieh; Shu-Huei Wang; Chia-Ying Lin; Yu-Chieh Wang; Hung-Hai Ku; Jaw-Wen Chen; Yuh-Lien Chen
Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity.
Journal of cellular biochemistry 2007;101(3):642-53.
2007: Shih-Hwa Chiou; Chung-Lan Kao; Yu-Lih Chang; Hung-Hai Ku; Yung-Jen Tsai; Han-Tso Lin; Chih-Ju Yen; Chi-Hsien Peng; Jen-Hwey Chiu; Tung-Hu Tsai
Evaluation of anti-Fas ligand-induced apoptosis and neural differentiation of PC12 cells treated with nerve growth factor using small interfering RNA method and sampling by microdialysis.
Analytical biochemistry 2007;363(1):46-57.
2007: Han-Tso Lin; Chung-Lan Kao; Kun-Hsiung Lee; Yuh-Lih Chang; Shih-Hwa Chiou; Fu-Ting Tsai; Tung-Hu Tsai; Dey-Chyi Sheu; Larry L-T Ho; Hung-Hai Ku
Enhancement of insulin-producing cell differentiation from embryonic stem cells using pax4-nucleofection method.
World journal of gastroenterology : WJG 2007;13(11):1672-9.
2007: Shih-Jen Chen; Chun-Lan Kao; Yuh-Lih Chang; Chih-Ju Yen; Jia-Wei Shui; Chan-Shiu Chien; I-Lin Chen; Tung-Hu Tsai; Hung-Hai Ku; Shih-Hwa Chiou
Antidepressant administration modulates neural stem cell survival and serotoninergic differentiation through bcl-2.
Current neurovascular research 2007;4(1):19-29.
2007: Shing-Jong Lin; I-Ta Lee; Yung-Hsiang Chen; Feng-Yen Lin; Li-Min Sheu; Hung-Hai Ku; Ming-Shi Shiao; Jaw-Wen Chen; Yuh-Lien Chen
Salvianolic acid B attenuates MMP-2 and MMP-9 expression in vivo in apolipoprotein-E-deficient mouse aorta and in vitro in LPS-treated human aortic smooth muscle cells.
Journal of cellular biochemistry 2007;100(2):372-84.
2007: Shing-Jong Lin; Song-Kun Shyue; Meng-Chun Shih; Ting-Hui Chu; Yung-Hsiang Chen; Hung-Hai Ku; Jaw-Wen Chen; Ka-Bik Tam; Yuh-Lien Chen
Superoxide dismutase and catalase inhibit oxidized low-density lipoprotein-induced human aortic smooth muscle cell proliferation: role of cell-cycle regulation, mitogen-activated protein kinases, and transcription factors.
Atherosclerosis 2007;190(1):124-34.
2006: C-K Perng; Hung-Hai Ku; Shih-Hwa Chiou; I-L Chen; Fu-Ting Tsai; Y-P Yang; K Y Chang; Chung-Lan Kao
Evaluation of wound healing effect on skin-defect nude mice by using human dermis-derived mesenchymal stem cells.
Transplantation proceedings 2006;38(9):3086-7.
2006: Shih-Hwa Chiou; Yi-Ping Yang; Jung-Chun Lin; Chih-Hung Hsu; Hua-Ci Jhang; Yu-Ting Yang; Chen-Hsen Lee; Larry L-T Ho; Wen-Ming Hsu; Hung-Hai Ku; Shih-Jen Chen; Steve S-L Chen; Margaret Dah-Tsyr Chang; Cheng-Wen Wu; Li-Jung Juan
The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6199-206.
2006: Han-Tso Lin; Shih-Hwa Chiou; Chung-Lan Kao; Yi-Ming Shyr; Chien-Jen Hsu; Yih-Wen Tarng; Larry L-T Ho; Ching-Fai Kwok; Hung-Hai Ku
Characterization of pancreatic stem cells derived from adult human pancreas ducts by fluorescence activated cell sorting.
World journal of gastroenterology : WJG 2006;12(28):4529-35.
2006: Shih-Hwa Chiou; Hung-Hai Ku; Tung-Hu Tsai; Heng-Liang Lin; Li-Hsin Chen; Chan-Shiu Chien; Larry L-T Ho; Chen-Hsen Lee; Yuh-Lih Chang
Moclobemide upregulated Bcl-2 expression and induced neural stem cell differentiation into serotoninergic neuron via extracellular-regulated kinase pathway.
British journal of pharmacology 2006;148(5):587-98.
2006: Yi-Wei Chen; Shih-Hwa Chiou; T-T Wong; Hung-Hai Ku; Han-Tso Lin; C-F Chung; S-H Yen; Chung-Lan Kao
Using gelatin scaffold with coated basic fibroblast growth factor as a transfer system for transplantation of human neural stem cells.
Transplantation proceedings 2006;38(5):1616-7.
2006: Yuh-Lien Chen; Cing-Siang Hu; Feng-Yen Lin; Yung-Hsiang Chen; Li-Min Sheu; Hung-Hai Ku; Ming-Shi Shiao; Jaw-Wen Chen; Shing-Jong Lin
Salvianolic acid B attenuates cyclooxygenase-2 expression in vitro in LPS-treated human aortic smooth muscle cells and in vivo in the apolipoprotein-E-deficient mouse aorta.
Journal of cellular biochemistry 2006;98(3):618-31.
2006: Shih-Hwa Chiou; Shih-Jen Chen; Chi-Hsien Peng; Yu-Li Chang; Hung-Hai Ku; Wen-Ming Hsu; Larry L-T Ho; Chen-Hsen Lee
Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived neural stem cell.
Biochemical and biophysical research communications 2006;343(2):391-400.
2006: Shih-Hwa Chiou; Chung-Lan Kao; Han-Tso Lin; Wen-Ser Tseng; Ren-Shyan Liu; Chen-Fun Chung; Hung-Hai Ku; Ching-Po Lin; Tai-Tong Wong
Monitoring the growth effect of xenotransplanted human medulloblastoma in an immunocompromised mouse model using in vitro and ex vivo green fluorescent protein imaging.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2006;22(5):475-80.
2005: Han-Tso Lin; Yih-Wen Tarng; Ying-Chou Chen; Chung-Lan Kao; Chien-Jen Hsu; Yi-Ming Shyr; Hung-Hai Ku; Shih-Hwa Chiou
Using human plasma supplemented medium to cultivate human bone marrow-derived mesenchymal stem cell and evaluation of its multiple-lineage potential.
Transplantation proceedings 2005;37(10):4504-5.
2005: I-Hsien Liu; Shih-Jen Chen; Hung-Hai Ku; Chung-Lan Kao; Fu-Ting Tsai; Wen-Ming Hsu; Chih-Wen Lo; Yueh-Hsiung Kuo; Cheng-Deng Kuo; Chen-Hsen Lee; Shih-Hwa Chiou
Comparison of the proliferation and differentiation ability between adult rat retinal stem cells and cerebral cortex-derived neural stem cells.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde 2005;219(3):171-6.
2005: Chi-Hsien Peng; Shih-Jen Chen; Chi-Kung Ho; Hung-Hai Ku; Hon-Wun Lin; Steve S-L Chen; Chih-Chiau Wu; Chin-Wen Chi; Wen-Ming Hsu; Shih-Hwa Chiou
Detection of HIV RNA levels in intraocular and cerebrospinal fluids in patients with AIDS-related cryptococcosis.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde 2005;219(2):101-6.
2005: Chung-Lan Kao; Shih-Hwa Chiou; Donald Ming-Tak Ho; Yann-Jang Chen; Ren-Shyan Liu; Chih-Wen Lo; Fu-Ting Tsai; Chi-Hung Lin; Hung-Hai Ku; Shang-Ming Yu; Tai-Tong Wong
Elevation of plasma and cerebrospinal fluid osteopontin levels in patients with atypical teratoid/rhabdoid tumor.
American journal of clinical pathology 2005;123(2):297-304.
2005: Shing-Jong Lin; Song-Kun Shyue; Ya-Yun Hung; Yung-Hsiang Chen; Hung-Hai Ku; Jaw-Wen Chen; Ka-Bik Tam; Yuh-Lien Chen
Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(2):334-40.
2005: Shih-Hwa Chiou; Chung-Lan Kao; Chi-Hsien Peng; Shih-Jen Chen; Yih-Wen Tarng; Hung-Hai Ku; Yu-Chih Chen; Yi-Ming Shyr; Ren-Shyan Liu; Chien-Jen Hsu; De-Ming Yang; Wen-Ming Hsu; Cheng-Deng Kuo; Chen-Hsen Lee
A novel in vitro retinal differentiation model by co-culturing adult human bone marrow stem cells with retinal pigmented epithelium cells.
Biochemical and biophysical research communications 2005;326(3):578-85.
2004: Shing-Jong Lin; Song-Kun Shyue; Po-Len Liu; Yung-Hsiang Chen; Hung-Hai Ku; Jaw-Wen Chen; Ka-Bik Tam; Yuh-Lien Chen
Adenovirus-mediated overexpression of catalase attenuates oxLDL-induced apoptosis in human aortic endothelial cells via AP-1 and C-Jun N-terminal kinase/extracellular signal-regulated kinase mitogen-activated protein kinase pathways.
Journal of molecular and cellular cardiology 2004;36(1):129-39.
2003: Shing-Jong Lin; Hui-Tzu Yen; Yung-Hsiang Chen; Hung-Hai Ku; Feng-Yen Lin; Yuh-Lien Chen
Expression of interleukin-1 beta and interleukin-1 receptor antagonist in oxLDL-treated human aortic smooth muscle cells and in the neointima of cholesterol-fed endothelia-denuded rabbits.
Journal of cellular biochemistry 2003;88(4):836-47.
2002: Yang-Hsin Shih; Se-Ling Wu; Wen-Fei Chiou; Hung-Hai Ku; Tsui-Ling Ko; Yu-Show Fu
Protective effects of tetramethylpyrazine on kainate-induced excitotoxicity in hippocampal culture.
Neuroreport 2002;13(4):515-9.
2002: Yung-Hsiang Chen; Shing-Jong Lin; Jaw-Wen Chen; Hung-Hai Ku; Yuh-Lien Chen
Magnolol attenuates VCAM-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in the aorta of cholesterol-fed rabbits.
British journal of pharmacology 2002;135(1):37-47.
2001: Yung-Hsiang Chen; Shing-Jong Lin; Hung-Hai Ku; Ming-Shi Shiao; Feng-Yen Lin; Jaw-Wen Chen; Yuh-Lien Chen
Salvianolic acid B attenuates VCAM-1 and ICAM-1 expression in TNF-alpha-treated human aortic endothelial cells.
Journal of cellular biochemistry 2001;82(3):512-21.