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Chia-Yi Kuan

Research Profile

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Chemicals & Drugs

Anatomy

Physiology

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Brain Hypoxia-Ischemia

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Dianer Yang; Jessica M Baumann; R Scott Dunn; Daniel A Lawrence; Diana M Lindquist; Niza Nemkul; Ahmed Shereen; Yu-Yo Sun; MARSHA WILLS-KARP; Chia-Yi Kuan
Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia.
Daren Wang; Roscoe O Brady; Mei Dai; Salim S El-Amouri; David Y Hui; Chia-Yi Kuan; Dao Pan
Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier.
Yu-Yo Sun; Dianer Yang; Chia-Yi Kuan
Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysis.

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2013: Dianer Yang; Jessica M Baumann; R Scott Dunn; Daniel A Lawrence; Diana M Lindquist; Niza Nemkul; Ahmed Shereen; Yu-Yo Sun; MARSHA WILLS-KARP; Chia-Yi Kuan
Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia.
Cerebral cortex (New York, N.Y. : 1991) 2013;23(5):1218-29.
2013: Daren Wang; Roscoe O Brady; Mei Dai; Salim S El-Amouri; David Y Hui; Chia-Yi Kuan; Dao Pan
Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):2999-3004.
2012: Yu-Yo Sun; Dianer Yang; Chia-Yi Kuan
Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysis.
Journal of neuroscience methods 2012;203(1):122-9.
2011: Kei-ichi Katayama; Jaime Melendez; Jessica M Baumann; Jennifer R Leslie; Bharesh K Chauhan; Niza Nemkul; Richard Lang; Chia-Yi Kuan; Yi Zheng; Yutaka Yoshida
Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(18):7607-12.
2011: Ahmed Shereen; Niza Nemkul; Dianer Yang; Faisal Adhami; R Scott Dunn; Missy L Hazen; Masato Nakafuku; Gang Ning; Diana M Lindquist; Chia-Yi Kuan
Ex vivo diffusion tensor imaging and neuropathological correlation in a murine model of hypoxia-ischemia-induced thrombotic stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(4):1155-69.
2009: Kevin A Burns; Brian Murphy; Steve C Danzer; Chia-Yi Kuan
Developmental and post-injury cortical gliogenesis: a genetic fate-mapping study with Nestin-CreER mice.
Glia 2009;57(10):1115-29.
2009: Dianer Yang; Niza Nemkul; Ahmed Shereen; Alice Jone; R Scott Dunn; Daniel Lawrence; Diana Lindquist; Chia-Yi Kuan
Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(27):8669-74.
2009: Lei Chen; Jaime Melendez; Kenneth Campbell; Chia-Yi Kuan; Yi Zheng
Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly.
Developmental biology 2009;325(1):162-70.
2008: Motoshi Nagao; Kenneth Campbell; Kevin Burns; Chia-Yi Kuan; Andreas Trumpp; Masato Nakafuku
Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway.
The Journal of cell biology 2008;183(7):1243-57.
2008: Vincent Ries; Robert M Silva; Tinmarla F Oo; Hsiao-Chun Cheng; Margarita Rzhetskaya; Nikolai Kholodilov; Richard A Flavell; Chia-Yi Kuan; Pasko Rakic; Robert E Burke
JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration.
Journal of neurochemistry 2008;107(6):1578-88.
2008: Faisal Adhami; Dan Yu; Wei Yin; Aryn Schloemer; Kevin A Burns; Guanghong Liao; Jay L Degen; Jun Chen; Chia-Yi Kuan
Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia.
The American journal of pathology 2008;172(6):1704-16.
2008: Daniel J Klionsky; Hagai Abeliovich; Patrizia Agostinis; Devendra K Agrawal; Gjumrakch Aliev; David S Askew; Misuzu Baba; Eric H Baehrecke; Ben A Bahr; Andrea Ballabio; Bruce A Bamber; Diane C Bassham; Ettore Bergamini; Xiaoning Bi; Martine Biard-Piechaczyk; Janice S Blum; Dale E Bredesen; Jeffrey L Brodsky; John H Brumell; Ulf T Brunk; Wilfried Bursch; Nadine Camougrand; Eduardo Cebollero; Francesco Cecconi; Yingyu Chen; Lih-Shen Chin; Augustine Choi; Charleen T Chu; Jongkyeong Chung; Peter G H Clarke; Robert S B Clark; Steven G Clarke; Corinne Clavé; John L Cleveland; Patrice Codogno; María I Colombo; Ana Coto-Montes; James M Cregg; Ana Maria Cuervo; Jayanta Debnath; Francesca Demarchi; Patrick B Dennis; Phillip A Dennis; Vojo Deretic; Rodney J Devenish; Federica Di Sano; J Fred Dice; Marian DiFiglia; Savithramma Dinesh-Kumar; Clark W Distelhorst; Mojgan Djavaheri-Mergny; Frank C Dorsey; Wulf Dröge; Michel Dron; William A Dunn; Michael Duszenko; N Tony Eissa; Zvulun Elazar; Audrey Esclatine; Eeva-Liisa Eskelinen; László Fésüs; Kim D Finley; Jose M. Fuentes; Juan Fueyo; Kozo Fujisaki; Brigitte Galliot; Fen-Biao Gao; David Gewirtz; Spencer B Gibson; Antje Gohla; Alfred L Goldberg; Ramon Gonzalez; Cristina González-Estévez; Sharon Gorski; Roberta Anne Gottlieb; Dieter Häussinger; You-Wen He; Kim Heidenreich; Joseph A Hill; Maria Høyer-Hansen; Xun Hu; Wei-Pang Huang; Akiko Iwasaki; Marja Jäättelä; William T Jackson; Xuejun Jiang; Shengkan Jin; Terje Johansen; Jae U. Jung; Motoni Kadowaki; Chanhee Kang; Ameeta Kelekar; David Kessel; Jan A K W Kiel; hong pyo kim; Adi Kimchi; Timothy J Kinsella; Kirill Kiselyov; Katsuhiko Kitamoto; Erwin Knecht; Masaaki Komatsu; Eiki Kominami; Seiji Kondo; Attila L Kovács; Guido Kroemer; Chia-Yi Kuan; Rakesh Kumar; Mondira Kundu; Jacques Landry; Marianne Laporte; Weidong Le; Huan-Yao Lei; Michael J Lenardo; Beth Levine; Andrew P Lieberman; Kah-Leong Lim; Fu-Cheng Lin; Willisa Liou; Leroy F Liu; Gabriel Lopez-Berestein; Carlos López-Otín; Bo Lu; Kay F Macleod; Walter Malorni; Wim Martinet; Ken Matsuoka; Josef Mautner; Alfred J Meijer; Alicia Meléndez; Paul Michels; Giovanni Miotto; wilhelm mistiaen; Noboru Mizushima; Baharia Mograbi; Iryna Monastyrska; Michael N Moore; Paula I Moreira; Yuji Moriyasu; Tomasz Motyl; Christian Münz; Leon O Murphy; Naweed I Naqvi; Thomas P Neufeld; Ichizo Nishino; Ralph A. Nixon; takeshi noda; Bernd Nürnberg; Michinaga Ogawa; Nancy L Oleinick; Laura J Olsen; Bulent Ozpolat; Shoshana Paglin; Glen E Palmer; Issidora Papassideri; Miles Parkes; David H Perlmutter; George Perry; Mauro Piacentini; Ronit Pinkas-Kramarski; Mark Prescott; Tassula Proikas-Cezanne; Nina Raben; Abdelhaq Rami; Fulvio Reggiori; Bärbel Rohrer; David C Rubinsztein; Kevin M Ryan; Junichi Sadoshima; Hiroshi Sakagami; Yasuyoshi Sakai; Marco Sandri; Chihiro Sasakawa; Miklós Sass; Claudio Schneider; Per O Seglen; Oleksandr Seleverstov; Jeffrey Settleman; John J Shacka; Irving M Shapiro; Andrei Sibirny; Elaine C M Silva-Zacarin; Hans-Uwe Simon; Cristiano Simone; Anne Simonsen; Mark A. Smith; Katharina Spanel-Borowski; Vickram Srinivas; Meredith Steeves; Harald Stenmark; Per E Stromhaug; Carlos S Subauste; Seiichiro Sugimoto; David Sulzer; Toshihiko Suzuki; Michele S Swanson; Ira Tabas; Fumihiko Takeshita; Nicholas J Talbot; Zsolt Tallóczy; Keiji Tanaka; Kozo Tanaka; Isei Tanida; Graham S Taylor; J. Paul Taylor; Alexei Terman; Gianluca Tettamanti; Craig Thompson; Michael Thumm; Aviva M Tolkovsky; Sharon A Tooze; Ray Truant; Lesya V Tumanovska; Yasuo Uchiyama; Takashi Ueno; Néstor L Uzcátegui; Ida van der Klei; Eva C Vaquero; Tibor Vellai; Michael W Vogel; Hong-Gang Wang; Paul Webster; John W Wiley; Zhijun Xi; Gutian Xiao; Joachim Yahalom; Jin-Ming Yang; George Yap; Xiao-Ming Yin; Tamotsu Yoshimori; Li Yu; Zhenyu Yue; Michisuke Yuzaki; Olga Zabirnyk; Xiaoxiang Zheng; Xiongwei Zhu; Russell L Deter
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Autophagy 2008;4(2):151-75.
2008: Daniel Y Weng; Yujin Zhang; Yasuhito Hayashi; Chia-Yi Kuan; Chia-Yang Liu; George Babcock; Wei-Lan Weng; Sandy Schwemberger; Winston W-Y Kao
Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice.
Molecular vision 2008;14():562-71.
2007: Kevin A Burns; Albert E Ayoub; Joshua J Breunig; Faisal Adhami; Wei-Lan Weng; Melissa C Colbert; Pasko Rakic; Chia-Yi Kuan
Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia.
Cerebral cortex (New York, N.Y. : 1991) 2007;17(11):2585-92.
2007: Norman J Kennedy; Gilles Martin; Anka G Ehrhardt; Julie Cavanagh-Kyros; Chia-Yi Kuan; Pasko Rakic; Richard A Flavell; Steven N Treistman; Roger J Davis
Requirement of JIP scaffold proteins for NMDA-mediated signal transduction.
Genes & development 2007;21(18):2336-46.
2007: Lei Chen; Guanghong Liao; Ronald R Waclaw; Kevin A Burns; Diana Linquist; Kenneth Campbell; Yi Zheng; Chia-Yi Kuan
Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(14):3884-93.
2007: Faisal Adhami; Aryn Schloemer; Chia-Yi Kuan
The roles of autophagy in cerebral ischemia.
Autophagy 2007;3(1):42-4.
2006: Guanghong Liao; Qinghua Tao; Matt Kofron; Juei-Suei Chen; Aryn Schloemer; Roger J Davis; Jen-Chih Hsieh; Chris Wylie; Janet Heasman; Chia-Yi Kuan
Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16313-8.
2006: Lei Chen; Guanghong Liao; Linda Yang; Kenneth Campbell; Masato Nakafuku; Chia-Yi Kuan; Yi Zheng
Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16520-5.
2006: Faisal Adhami; Guanghong Liao; Yury M Morozov; Aryn Schloemer; Vincent J Schmithorst; John N Lorenz; R Scott Dunn; Charles V Vorhees; MARSHA WILLS-KARP; Jay L Degen; Roger J Davis; Noboru Mizushima; Pasko Rakic; Bernard Dardzinski; Scott K Holland; Frank R Sharp; Chia-Yi Kuan
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy.
The American journal of pathology 2006;169(2):566-83.
2005: Lei Wang; Linda Yang; Kevin Burns; Chia-Yi Kuan; Yi Zheng
Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13484-9.
2005: Zhengtao Chu; Ying Sun; Chia-Yi Kuan; Gregory A Grabowski; Xiaoyang Qi
Saposin C: neuronal effect and CNS delivery by liposomes.
Annals of the New York Academy of Sciences 2005;1053():237-46.
2005: Robert M Silva; Chia-Yi Kuan; Pasko Rakic; Robert E Burke
Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2005;20(6):653-64.
2005: Linping Wang; John P Mear; Chia-Yi Kuan; Melissa C Colbert
Retinoic acid induces CDK inhibitors and growth arrest specific (Gas) genes in neural crest cells.
Development, growth & differentiation 2005;47(3):119-30.
2005: Kevin A Burns; Chia-Yi Kuan
Low doses of bromo- and iododeoxyuridine produce near-saturation labeling of adult proliferative populations in the dentate gyrus.
The European journal of neuroscience 2005;21(3):803-7.
2005: Chia-Yi Kuan; Robert E Burke
Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy.
Current drug targets. CNS and neurological disorders 2005;4(1):63-7.
2005: Stephan Brecht; Rainer Kirchhof; Ansgar Michael Chromik; Mette Georgi Willesen; Thomas Nicolaus; Gennadij Raivich; Jan Wessig; Vicki Waetzig; Mario Goetz; Malte Claussen; Damien D Pearse; Chia-Yi Kuan; Elisabetta Vaudano; Axel Behrens; Erwin Wagner; Richard A Flavell; Roger J Davis; Thomas Herdegen
Specific pathophysiological functions of JNK isoforms in the brain.
The European journal of neuroscience 2005;21(2):363-77.
2004: Chia-Yi Kuan; Aryn Schloemer; Aigang Lu; Kevin A Burns; Wei-Lan Weng; Michael T Williams; Kenneth I Strauss; Charles V Vorhees; Richard A Flavell; Roger J Davis; Frank R Sharp; Pasko Rakic
Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(47):10763-72.
2004: William Defoor; Chia-Yi Kuan; Malinda Pinkerton; Curtis Sheldon; Alfor G Lewis
Modulation of germ cell apoptosis with a nitric oxide synthase inhibitor in a murine model of congenital cryptorchidism.
The Journal of urology 2004;172(4 Pt 2):1731-5; discussion 1735.
2003: Chia-Yi Kuan; Alan J Whitmarsh; Derek D Yang; Guanghong Liao; Aryn Schloemer; Chen Dong; Jue Bao; Kenneth J Banasiak; Gabriel G Haddad; Richard A Flavell; Roger J Davis; Pasko Rakic
A critical role of neural-specific JNK3 for ischemic apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15184-9.
2003: Qiangrong Liang; Orlando F Bueno; Benjamin J Wilkins; Chia-Yi Kuan; Ying Xia; Jeffery D Molkentin
c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling.
The EMBO journal 2003;22(19):5079-89.
2003: Jin Qian; Melissa C Colbert; David Witte; Chia-Yi Kuan; Eric Gruenstein; Hanna Osinska; Beate Lanske; Henry M Kronenberg; Thomas Landes Clemens
Midgestational lethality in mice lacking the parathyroid hormone (PTH)/PTH-related peptide receptor is associated with abrupt cardiomyocyte death.
Endocrinology 2003;144(3):1053-61.
2001: Alan J Whitmarsh; Chia-Yi Kuan; Norman J Kennedy; Nyaya Kelkar; Tarik F Haydar; John P Mordes; M Appel; A A Rossini; Stephen N Jones; Richard A Flavell; Pasko Rakic; Roger J Davis
Requirement of the JIP1 scaffold protein for stress-induced JNK activation.
Genes & development 2001;15(18):2421-32.
2001: Shane R Bruckner; Steven Tammariello; Chia-Yi Kuan; Richard A Flavell; P Rakic; Steven Estus
JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons.
Journal of neurochemistry 2001;78(2):298-303.
2001: Ronald W Oppenheim; R A Flavell; Sharon Vinsant; David Prevette; Chia-Yi Kuan; P Rakic
Programmed cell death of developing mammalian neurons after genetic deletion of caspases.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(13):4752-60.
2000: Chia-Yi Kuan; K A Roth; R A Flavell; P Rakic
Mechanisms of programmed cell death in the developing brain.
Trends in neurosciences 2000;23(7):291-7.
2000: Kevin A Roth; Chia-Yi Kuan; Tarik F Haydar; C D'Sa-Eipper; Kenneth Shindler; TS Zheng; Keisuke Kuida; Richard A Flavell; Pasko Rakic
Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):466-71.
2000: Chia-Yi Kuan; R A Flavell; P Rakic
Programmed cell death in mouse brain development.
Results and problems in cell differentiation 2000;30():145-62.
2000: Santosh R D'Mello; Chia-Yi Kuan; R A Flavell; P Rakic
Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassium.
Journal of neuroscience research 2000;59(1):24-31.
1999: Tarik F Haydar; Chia-Yi Kuan; R A Flavell; Pasko Rakic
The role of cell death in regulating the size and shape of the mammalian forebrain.
Cerebral cortex (New York, N.Y. : 1991) 1999;9(6):621-6.
1999: Chia-Yi Kuan; Derek D Yang; D R Samanta Roy; Roger J Davis; Pasko Rakic; Richard A Flavell
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.
Neuron 1999;22(4):667-76.
1998: Keisuke Kuida; Tarik F Haydar; Chia-Yi Kuan; Y Gu; Choji Taya; H Karasuyama; Michael S S Su; Pasko Rakic; RA Flavell
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9.
Cell 1998;94(3):325-37.
1997: Derek D Yang; Chia-Yi Kuan; Alan J Whitmarsh; Mercedes Rincón; T S Zheng; Roger J Davis; Pasko Rakic; Richard A Flavell
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene.
Nature 1997;389(6653):865-70.
1997: Chia-Yi Kuan; E A Elliott; Richard A Flavell; Pasko Rakic
Restrictive clonal allocation in the chimeric mouse brain.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3374-9.
1996: Keisuke Kuida; T S Zheng; S Na; Chia-Yi Kuan; D Yang; H Karasuyama; Pasko Rakic; Richard A Flavell
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice.
Nature 1996;384(6607):368-72.