Kamil Kuca

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Vrdoljak Ana Lucic; Berend Suzana; Zeljezic Davor; Piljac-Zegarac Jasenka; Plestina Stjepko; Kuca Kamil; Radic Bozica; Mladinic Marin; Kopjar Nevenka
Irinotecan side effects relieved by the use of HI-6 oxime: in vivo experimental approach.
Karasova Jana Zdarova; Bajgar Jiri; Jun Daniel; Pavlikova Ruzena; Kuca Kamil
Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX.
Soukup Ondrej; Proska Jan; Binder Jiri; Karasova Jana Zdarova; Tobin Gunnar; Jun Daniel; Marek Jan; Musílek Kamil; Fusek Josef; Kuca Kamil
Methylacridinium and its cholinergic properties.

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All Publications

2009: Vrdoljak Ana Lucic; Berend Suzana; Zeljezic Davor; Piljac-Zegarac Jasenka; Plestina Stjepko; Kuca Kamil; Radic Bozica; Mladinic Marin; Kopjar Nevenka
Irinotecan side effects relieved by the use of HI-6 oxime: in vivo experimental approach.
Basic & clinical pharmacology & toxicology 2009;105(6):401-9.
2009: Karasova Jana Zdarova; Bajgar Jiri; Jun Daniel; Pavlikova Ruzena; Kuca Kamil
Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX.
Neurotoxicity research 2009;16(4):356-60.
2009: Soukup Ondrej; Proska Jan; Binder Jiri; Karasova Jana Zdarova; Tobin Gunnar; Jun Daniel; Marek Jan; Musílek Kamil; Fusek Josef; Kuca Kamil
Methylacridinium and its cholinergic properties.
Neurotoxicity research 2009;16(4):372-7.
2009: Jeong Hee Chun; Park No-Joong; Chae Chong Hak; Musilek Kamil; Kassa Jiri; Kuca Kamil; Jung Young-Sik
Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent.
Bioorganic & medicinal chemistry 2009;17(17):6213-7.
2009: Kuca Kamil; Cabal Jiri; Jung Yung Sik; Musilek Kamil; Soukup Ondrej; Jun Daniel; Pohanka Miroslav; Musilova Lucie; Karasová Jana; Novotný Ladislav; Hrabinova Martina
Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127.
Basic & clinical pharmacology & toxicology 2009;105(3):207-10.
2009: Kassa Jiri; Karasova Jana; Bajgar Jiri; Kuca Kamil; Musilek Kamil; Kopelikova Irena
A comparison of the reactivating and therapeutic efficacy of newly developed bispyridinium oximes (K250, K251) with commonly used oximes against tabun in rats and mice.
Journal of enzyme inhibition and medicinal chemistry 2009;24(4):1040-4.
2009: Veinlichova Alena; Jancova Petra; Siller Michal; Anzenbacher Pavel; Kuca Kamil; Jun Daniel; Fusek Josef; Anzenbacherova Eva
Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro.
Chemico-biological interactions 2009;180(3):449-53.
2009: Pohanka Miroslav; Karasova Jana Zdarova; Musilek Kamil; Kuca Kamil; Kassa Jiri
Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy.
Journal of applied toxicology : JAT 2009;29(6):483-8.
2009: Musilova Lucie; Kuca Kamil; Jung Young-Sik; Jun Daniel
In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase.
Clinical toxicology (Philadelphia, Pa.) 2009;47(6):545-50.
2009: Nurulain S M; Lorke D E; Hasan M Y; Shafiullah M; Kuca K; Musilek K; Petroianu G A
Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime.
Neurotoxicity research 2009;16(1):60-7.
2009: Kassa Jiri; Karasova Jana Zdarova; Musilek Kamil; Kuca Kamil
A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice.
Toxicology mechanisms and methods 2009;19(5):346-50.
2009: Karasova Jana Zdarova; Kassa Jiri; Musilek Kamil; Pohanka Miroslav; Novotny Ladislav; Kuca Kamil
Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats.
International journal of molecular sciences 2009;10(7):3065-75.
2009: Lorke D E; Hasan M Y; Nurulain S M; Kuca K; Schmitt A; Petroianu G A
Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6.
Toxicology mechanisms and methods 2009;19(4):327-33.
2009: Kassa Jiri; Karasova Jana Zdarova; Musilek Kamil; Kuca Kamil; Jung And Young-Sik
A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats.
Toxicology mechanisms and methods 2009;19(3):232-8.
2009: Kassa Jiri; Karasova Jana Zdarova; Bajgar Jiri; Tesarova Sandra; Kuca Kamil; Musilek Kamil
Evaluation of the neuroprotective efficacy of newly developed oximes (K206, K269) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats.
Basic & clinical pharmacology & toxicology 2009;104(3):228-35.
2009: Kassa Jiri; Karasova Jana; Musilek Kamil; Kuca Kamil; Bajgar Jiri
An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice.
Clinical toxicology (Philadelphia, Pa.) 2009;47(1):72-6.
2009: Bajgar Jiri; Fusek Josef; Kassa Jiri; Kuca Kamil; Jun Daniel
Chemical aspects of pharmacological prophylaxis against nerve agent poisoning.
Current medicinal chemistry 2009;16(23):2977-86.
2009: Wu Qinghua; Jezkova Alena; Yuan Zonghui; Pavlikova Lucie; Dohnal Vlastimil; Kuca Kamil
Biological degradation of aflatoxins.
Drug metabolism reviews 2009;41(1):1-7.
2009: Kassa Jiri; Karasova Jana; Vasina Libor; Bajgar Jiri; Kuca Kamil; Musilek Kamil
A comparison of neuroprotective efficacy of newly developed oximes (K203, K206) and commonly used oximes (obidoxime, HI-6) in tabun-poisoned rats.
Drug and chemical toxicology 2009;32(2):128-38.
2009: Hajek Petr; Bajgar Jiri; Slizova Dasa; Krs Otakar; Kuca Kamil; Capek Lukas; Fusek Josef
Different inhibition of acetylcholinesterase in selected parts of the rat brain following intoxication with VX and Russian VX.
Drug and chemical toxicology 2009;32(1):1-8.
2009: Pohanka Miroslav; Musilek Kamil; Kuca Kamil
Progress of biosensors based on cholinesterase inhibition.
Current medicinal chemistry 2009;16(14):1790-8.
2008: Pohanka Miroslav; Jun Daniel; Kuca Kamil
Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation.
Journal of enzyme inhibition and medicinal chemistry 2008;23(6):781-4.
2008: Kassa Jiri; Karasova Jana; Bajgar Jiri; Kuca Kamil; Musilek Kamil
A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice.
Journal of enzyme inhibition and medicinal chemistry 2008;23(6):776-80.
2008: Karasova Jana Zdarova; Kassa Jiri; Jung Young-Sik; Musilek Kamil; Pohanka Miroslav; Kuca Kamil
Effect of Several New and Currently Available Oxime Cholinesterase Reactivators on Tabun-intoxicated Rats.
International journal of molecular sciences 2008;9(11):2243-52.
2008: Pohanka Miroslav; Kuca Kamil; Kassa Jiri
New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine.
Neuro endocrinology letters 2008;29(5):755-8.
2008: Soukup Ondrej; Pohanka Miroslav; Tobin Gunnar; Jun Daniel; Fusek Josef; Musilek Kamil; Marek Jan; Kassa Jiri; Kuca Kamil
The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder.
Neuro endocrinology letters 2008;29(5):759-62.
2008: Kassa Jiri; Kuca Kamil; Karasova Jana; Musilek Kamil
The development of new oximes and the evaluation of their reactivating, therapeutic and neuroprotective efficacy against tabun.
Mini reviews in medicinal chemistry 2008;8(11):1134-43.
2008: Pohanka Miroslav; Jun Daniel; Kuca Kamil
Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators.
Talanta 2008;77(1):451-4.
2008: Lorke D E; Nurulain S M; Hasan M Y; Kuca K; Musilek K; Petroianu G A
Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity.
Journal of applied toxicology : JAT 2008;28(7):920-8.
2008: Musilek Kamil; Kucera Jiri; Jun Daniel; Dohnal Vlastimil; Opletalova Veronika; Kuca Kamil
Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry 2008;16(17):8218-23.
2008: Jun D; Musilova L; Kuca K; Kassa J; Bajgar J
Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro.
Chemico-biological interactions 2008;175(1-3):421-4.
2008: Bajgar Jiri; Fusek Josef; Kassa Jiri; Jun Daniel; Kuca Kamil; Hajek Petr
An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents.
Chemico-biological interactions 2008;175(1-3):281-5.
2008: Oh Kyung-Ae; Park No-Joong; Park No-Sang; Kuca Kamil; Jun Daniel; Jung Young-Sik
Reactivation of DFP- and paraoxon-inhibited acetylcholinesterases by pyridinium oximes.
Chemico-biological interactions 2008;175(1-3):365-7.
2008: Kassa Jiri; Jun Daniel; Karasova Jana; Bajgar Jiri; Kuca Kamil
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats.
Chemico-biological interactions 2008;175(1-3):425-7.
2008: Berend Suzana; Vrdoljak Ana Lucic; Radic Bozica; Kuca Kamil
New bispyridinium oximes: in vitro and in vivo evaluation of their biological efficiency in soman and tabun poisoning.
Chemico-biological interactions 2008;175(1-3):413-6.
2008: Calic Maja; Bosak Anita; Kuca Kamil; Kovarik Zrinka
Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases.
Chemico-biological interactions 2008;175(1-3):305-8.
2008: Pejchal Jaroslav; Osterreicher Jan; Kuca Kamil; Jun Daniel; Bajgar Jiri; Kassa Jiri
The influence of acetylcholinesterase reactivators on selected hepatic functions in rats.
Basic & clinical pharmacology & toxicology 2008;103(2):119-23.
2008: Cervenka Frantisek; Koleckar Vit; Rehakova Zuzana; Jahodar Ludek; Kunes Jiri; Opletal Lubomir; Hyspler Radomir; Jun Daniel; Kuca Kamil
Evaluation of natural substances from Evolvulus alsinoides L. with the purpose of determining their antioxidant potency.
Journal of enzyme inhibition and medicinal chemistry 2008;23(4):574-8.
2008: Koleckar Vit; Kubikova Katerina; Rehakova Zuzana; Kuca Kamil; Jun Daniel; Jahodar Ludek; Opletal Lubomir
Condensed and hydrolysable tannins as antioxidants influencing the health.
Mini reviews in medicinal chemistry 2008;8(5):436-47.
2008: Patocka Jiri; Jun Daniel; Kuca Kamil
Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease.
Current drug metabolism 2008;9(4):332-5.
2008: Musilek Kamil; Jampilek Josef; Dohnal Jiri; Jun Daniel; Gunn-Moore Frank; Dolezal Martin; Kuca Kamil
RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker.
Analytical and bioanalytical chemistry 2008;391(1):367-72.
2008: Jun Daniel; Stodulka Petr; Kuca Kamil; Koleckar Vit; Dolezal Bohuslav; Simon Peter; Veverka Miroslav
TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate.
Journal of chromatographic science 2008;46(4):316-9.
2008: Koleckar Vit; Opletal Lubomir; Brojerova Eliska; Rehakova Zuzana; Cervenka Frantisek; Kubikova Katerina; Kuca Kamil; Jun Daniel; Polasek Miroslav; Kunes Jiri; Jahodar Ludek
Evaluation of natural antioxidants of Leuzea carthamoides as a result of a screening study of 88 plant extracts from the European Asteraceae and Cichoriaceae.
Journal of enzyme inhibition and medicinal chemistry 2008;23(2):218-24.
2008: Stodulka Petr; Koleckar Vit; Jun Daniel; Kuca Kamil; Rehakova Zuzana; Kubikova Katerina; Jahodar Ludek; Kunes Jiri; Opletal Lubomir
High-performance liquid chromatography analysis of four Leuzea carthamoides flavonoids.
Journal of chromatographic science 2008;46(2):162-4.
2008: Musilek Kamil; Holas Ondrej; Kuca Kamil; Jun Daniel; Dohnal Vlastimil; Opletalova Veronika; Dolezal Martin
Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase.
Journal of enzyme inhibition and medicinal chemistry 2008;23(1):70-6.
2008: Dohnal Vlastimil; Jezkova Alena; Jun Daniel; Kuca Kamil
Metabolic pathways of T-2 toxin.
Current drug metabolism 2008;9(1):77-82.
2008: Kassa Jiri; Karasova Jana; Musilek Kamil; Kuca Kamil
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Toxicology 2008;243(3):311-6.
2008: da Silva Aline P; Farina Marcelo; Franco Jeferson L; Dafre Alcir L; Kassa Jiri; Kuca Kamil
Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex.
Neurotoxicology 2008;29(1):184-9.
2008: Kassa Jirí; Karasová Jana Zd'árová; Tesarová Sandra; Kuca Kamil; Musílek Kamil
A comparison of the neuroprotective efficacy of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2008;51(4):215-21.
2008: Pohanka Miroslav; Jun Daniel; Kalasz Huba; Kuca Kamil
Cholinesterase biosensor construction - a review.
Protein and peptide letters 2008;15(8):795-8.
2008: Csermely T; Kalász H; Petroianu G A; Kuca K; Darvas F; Ludányi K; Mudhafar A A; Tekes K
Analysis of pyridinium aldoximes - a chromatographic approach.
Current medicinal chemistry 2008;15(23):2401-18.
2008: Kassa Jiri; Karasova Jana; Musilek Kamil; Kuca Kamil; Jung Young-Sik
A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Drug and chemical toxicology 2008;31(3):371-81.
2008: Koleckar Vit; Brojerova Eliska; Rehakova Zuzana; Kubikova Katerina; Cervenka Frantisek; Kuca Kamil; Jun Daniel; Hronek Miloslav; Opletalova Veronika; Opletal Lubomir
In vitro antiplatelet activity of flavonoids from Leuzea carthamoides.
Drug and chemical toxicology 2008;31(1):27-35.
2008: Jun Daniel; Kuca Kamil; Picha Jan; Koleckar Vit; Marek Jan
Potency of novel oximes to reactivate sarin inhibited human cholinesterases.
Drug and chemical toxicology 2008;31(1):1-9.
2007: Bajgar J; Kuca K; Jun D; Bartosova L; Fusek J
Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents.
Current drug metabolism 2007;8(8):803-9.
2007: Musilek Kamil; Jun Daniel; Cabal Jiri; Kassa Jiri; Gunn-Moore Frank; Kuca Kamil
Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).
Journal of medicinal chemistry 2007;50(22):5514-8.
2007: Kassa Jiri; Jun Daniel; Kuca Kamil; Bajgar Jiri
Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats.
Basic & clinical pharmacology & toxicology 2007;101(5):328-32.
2007: Musilek Kamil; Holas Ondrej; Jun Daniel; Dohnal Vlastimil; Gunn-Moore Frank; Opletalova Veronika; Dolezal Martin; Kuca Kamil
Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry 2007;15(21):6733-41.
2007: Benko B; Kalász H; Ludányi K; Petroianu G; Kuca K; Darvas F; Tekes K
In vitro and in vivo metabolisms of K-48.
Analytical and bioanalytical chemistry 2007;389(4):1243-7.
2007: Lorke D E; Hasan M Y; Nurulain S M; Sheen R; Kuca K; Petroianu G A
Entry of two new asymmetric bispyridinium oximes (K-27 and K-48) into the rat brain: comparison with obidoxime.
Journal of applied toxicology : JAT 2007;27(5):482-90.
2007: Petroianu G A; Nurulain S M; Nagelkerke N; Shafiullah M; Kassa J; Kuca K
Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon.
Journal of applied toxicology : JAT 2007;27(5):453-7.
2007: Bajgar J; Kuca K; Fusek J; Karasova J; Kassa J; Cabal J; Jun D; Blaha V
Inhibition of blood cholinesterases following intoxication with VX and its derivatives.
Journal of applied toxicology : JAT 2007;27(5):458-63.
2007: Musilek Kamil; Holas Ondrej; Kuca Kamil; Jun Daniel; Dohnal Vlastimil; Dolezal Martin
Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
Journal of enzyme inhibition and medicinal chemistry 2007;22(4):425-32.
2007: Wiesner Jirí; Kriz Zdenek; Kuca Kamil; Jun Daniel; Koca Jaroslav
Acetylcholinesterases--the structural similarities and differences.
Journal of enzyme inhibition and medicinal chemistry 2007;22(4):417-24.
2007: Gyenge Melinda; Kalász Huba; Petroianu George A; Laufer Rudolf; Kuca Kamil; Tekes Kornélia
Measurement of K-27, an oxime-type cholinesterase reactivator by high-performance liquid chromatography with electrochemical detection from different biological samples.
Journal of chromatography. A 2007;1161(1-2):146-51.
2007: Dohnal V; Jezková A; Kuca K; Jun D
[T-2 toxin: occurrence and detection]
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2007;56(4):174-7.
2007: Kuca Kamil; Jun Daniel; Cabal Jiri; Musilova Lucie
Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases: an in vitro study.
Basic & clinical pharmacology & toxicology 2007;101(1):25-8.
2007: Kassa Jiri; Jun Daniel; Kuca Kamil
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats.
Journal of enzyme inhibition and medicinal chemistry 2007;22(3):297-300.
2007: Kuca Kamil; Cabal Jiri; Jun Daniel; Hrabinova Martina
Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin.
Clinical toxicology (Philadelphia, Pa.) 2007;45(5):512-5.
2007: Musilek Kamil; Holas Ondrej; Kuca Kamil; Jun Daniel; Dohnal Vlastimil; Opletalova Veronika; Dolezal Martin
Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry letters 2007;17(11):3172-6.
2007: Bajgar Jiri; Fusek Josef; Kuca Kamil; Bartosova Lucie; Jun Daniel
Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction.
Mini reviews in medicinal chemistry 2007;7(5):461-6.
2007: Koleckár V; Brojerová E; Opletal L; Jun D; Kuca K
[Antioxidants, free radicals, mechanism of action and application in the therapy of the sulfur mustard caused injury]
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2007;56(2):73-6.
2007: Petroianu G A; Arafat K; Nurulain S M; Kuca K; Kassa J
In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon.
Journal of applied toxicology : JAT 2007;27(2):168-75.
2007: Kuca Kamil; Cabal Jiri; Jun Daniel; Musilek Kamil
In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases.
Neurotoxicity research 2007;11(2):101-6.
2007: Bajgar Jiri; Hajek Petr; Slizova Dasa; Krs Otakar; Fusek Josef; Kuca Kamil; Jun Daniel; Bartosova Lucie; Blaha Vaclav
Changes of acetylcholinesterase activity in different rat brain areas following intoxication with nerve agents: biochemical and histochemical study.
Chemico-biological interactions 2007;165(1):14-21.
2007: Pohanka Miroslav; Kuca Kamil; Jun Daniel
Amperometric biosensor for pesticide methamidophos assay.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2007;50(4):239-41.
2007: Musílek Kamil; Kuca Kamil; Jun Daniel
Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX).
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2007;50(3):203-6.
2007: Kuca Kamil; Jun Daniel; Bajgar Jiri
Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications.
Current pharmaceutical design 2007;13(33):3445-52.
2007: Kuca Kamil; Marek Jan; Stodulka Petr; Musilek Kamil; Hanusova Petra; Hrabinova Martina; Jun Daniel
Preparation of benzalkonium salts differing in the length of a side alkyl chain.
Molecules (Basel, Switzerland) 2007;12(10):2341-7.
2007: Kuca Kamil; Musilek Kamil; Paar Martin; Jun Daniel; Stodulka Petr; Hrabinova Martina; Marek Jan
Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator.
Molecules (Basel, Switzerland) 2007;12(8):1964-72.
2007: Musilek Kamil; Kuca Kamil; Dohnal Vlastimil; Jun Daniel; Marek Jan; Koleckar Vit
Two step synthesis of a non-symmetric acetylcholinesterase reactivator.
Molecules (Basel, Switzerland) 2007;12(8):1755-61.
2007: Bajgar Jiri; Bartosova Lucie; Kuca Kamil; Jun Daniel; Fusek Josef
Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase.
Drug and chemical toxicology 2007;30(4):351-9.
2007: Pohanka Miroslav; Jun Daniel; Kuca Kamil
Mycotoxin assays using biosensor technology: a review.
Drug and chemical toxicology 2007;30(3):253-61.
2007: Kuca Kamil; Jun Daniel; Bajgar Jiri
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
Drug and chemical toxicology 2007;30(1):31-40.
2006: Kuca Kamil; Jun Daniel
Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes.
Journal of medical toxicology : official journal of the American College of Medical Toxicology 2006;2(4):141-6.
2006: Bajgar Jiri; Bartosova Lucie; Fusek Josef; Jun Daniel; Kuca Kamil
Equine butyrylcholinesterase protects rats against inhalation exposure to sublethal sarin concentrations.
Arhiv za higijenu rada i toksikologiju 2006;57(4):391-5.
2006: Racakova Veronika; Hrabinova Martina; Jun Daniel; Kuca Kamil
Substituted monoquaternary oximes as reactivators of cyclosarin--and chlorpyrifos--inhibited acetylcholinesterase.
Arhiv za higijenu rada i toksikologiju 2006;57(4):387-90.
2006: Kuca Kamil; Cabal Jiri; Jun Daniel; Bajgar Jiri; Hrabinova Martina
Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases.
Journal of enzyme inhibition and medicinal chemistry 2006;21(6):663-6.
2006: Lucic Vrdoljak Ana; Calic Maja; Radic Bozica; Berend Suzana; Jun Daniel; Kuca Kamil; Kovarik Zrinka
Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning.
Toxicology 2006;228(1):41-50.
2006: Musilek Kamil; Holas Ondrej; Kuca Kamil; Jun Daniel; Dohnal Vlastimil; Dolezal Martin
Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry letters 2006;16(21):5673-6.
2006: Hrabinova Martina; Musilek Kamil; Jun Daniel; Kuca Kamil
New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin.
Journal of enzyme inhibition and medicinal chemistry 2006;21(5):515-9.
2006: Kassa Jiri; Kuca Kamil; Cabal Jiri; Paar Martin
A comparison of the efficacy of new asymmetric bispyridinium oximes (K027, K048) with currently available oximes against tabun by in vivo methods.
Journal of toxicology and environmental health. Part A 2006;69(20):1875-82.
2006: Kassa Jiri; Jun Daniel; Kuca Kamil
The reactivating and therapeutic efficacy of oximes to counteract Russian VX poisonings.
International journal of toxicology 2006;25(5):397-401.
2006: Bajgar J; Fusek J; Bartosova L; Jun D; Kuca K
Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents.
Journal of applied toxicology : JAT 2006;26(5):439-43.
2006: Oh Kyung-Ae; Yang Garp Yeol; Jun Daniel; Kuca Kamil; Jung Young-Sik
Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)n OCH2 linkers between pyridinium rings and their reactivity against VX.
Bioorganic & medicinal chemistry letters 2006;16(18):4852-5.
2006: Vesela Sarka; Ondruska Vlastimil; Kuca Kamil; Patocka Jiri
Tests with Daphnia magna: a new approach to prescreen toxicity of newly synthesized acetylcholinesterase reactivators.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):427-32.
2006: Kuca Kamil; Cabal Jiri; Kassa Jiri; Jun Daniel; Hrabinova Martina
In vitro potency of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase.
Journal of toxicology and environmental health. Part A 2006;69(15):1431-40.
2006: Kalász H; Hasan M Y; Sheen R; Kuca K; Petroianu G; Ludányi K; Gergely A; Tekes K
HPLC analysis of K-48 concentration in plasma.
Analytical and bioanalytical chemistry 2006;385(6):1062-7.
2006: Tekes K; Hasan M Y; Sheen R; Kuca K; Petroianu G; Ludányi K; Kalász H
High-performance liquid chromatographic determination of the plasma concentration of K-27, a novel oxime-type cholinesterase reactivator.
Journal of chromatography. A 2006;1122(1-2):84-7.
2006: Bartosova Lucie; Kuca Kamil; Kunesova Gabriela; Jun Daniel
The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure.
Neurotoxicity research 2006;9(4):291-6.
2006: Musílek K; Kuca K; Jun D; Dohnal V; Kim T H; Jung Y S; Dolezal M
[Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos]
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2006;55(3):115-9.
2006: Petroianu G A; Nurulain S M; Nagelkerke N; Al-Sultan M A H; Kuca K; Kassa J
Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon.
Journal of applied toxicology : JAT 2006;26(3):262-8.
2006: Jun Daniel; Kuca Kamil; Hronek Miloslav; Opletal Lubomir
Effect of some acetylcholinesterase reactivators on human platelet aggregation in vitro.
Journal of applied toxicology : JAT 2006;26(3):258-61.
2006: Kuca Kamil; Jun Daniel; Cabal Jiri; Hrabinova Martina; Bartosova Lucie; Opletalova Veronika
Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent.
Basic & clinical pharmacology & toxicology 2006;98(4):389-94.
2006: Kuca Kamil; Juna Daniel; Musilek Kamil
Structural requirements of acetylcholinesterase reactivators.
Mini reviews in medicinal chemistry 2006;6(3):269-77.
2006: Calic Maja; Vrdoljak Ana Lucic; Radic Bozica; Jelic Dubravko; Jun Daniel; Kuca Kamil; Kovarik Zrinka
In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity.
Toxicology 2006;219(1-3):85-96.
2006: Musilek Kamil; Kuca Kamil; Jun Daniel; Dohnal Vlastimil; Dolezal Martin
Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry letters 2006;16(3):622-7.
2006: Petroianu G A; Arafat K; Kuca K; Kassa J
Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon.
Journal of applied toxicology : JAT 2006;26(1):64-71.
2006: Kuca Kamil; Pícha Jan; Jun Daniel
Reactivation potency of new group of acetylcholinesterase reactivators and their comparison with currently available oximes.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2006;49(4):233-5.
2006: Kuca Kamil; Cabal Jiri; Jun Daniel; Hrabinova Martina
In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings.
Drug and chemical toxicology 2006;29(4):443-9.
2005: Kuca Kamil; Cabal Jirí; Jun Daniel; Kassa Jirí; Bartosová Lucie; Kunesová Gabriela; Dohnal Vlastimil
Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):429-31.
2005: Bartosová Lucie; Kuca Kamil; Kunesová Gabriela
Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):425-7.
2005: Kassa Jirí; Kuca Kamil; Cabal Jirí
A comparison of the potency of trimedoxime and other currently available oximes to reactivate tabun-inhibited acetylcholinesterase and eliminate acute toxic effects of tabun.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):419-23.
2005: Dohnal Vlastimil; Kuca Kamil; Jun Daniel
What are artificial neural networks and what they can do?
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):221-4.
2005: Jun Daniel; Kuca Kamil; Cabal Jiri; Bartosova Lucie; Kunesova Gabriela; Kassa Jiri
Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species.
Chemico-biological interactions 2005;157-158():385-7.
2005: Kuca Kamil; Bartosova Lucie; Kassa Jiri; Cabal Jiri; Bajgar Jiri; Kunesova Gabriela; Jun Daniel
Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo.
Chemico-biological interactions 2005;157-158():367-8.
2005: Krejcova-Kunesova Gabriela; Bartosova Lucie; Kuca Kamil
Signs of cyclosarin-induced neurotoxicity and its pharmacological treatment with quaternary pyridinium-oximes reactivators.
Toxicology 2005;216(1):32-40.
2005: Bartosova Lucie; Kuca Kamil; Jun Daniel; Kunesova Gabriela
Bispyridinium oximes as antidotal treatment of cyclosarin poisoning-in vitro and in vivo testing.
International journal of toxicology 2005;24(6):399-402.
2005: Kuca Kamil; Cabal Jiri; Musilek Kamil; Jun Daniel; Bajgar Jiri
Effective bisquaternary reactivators of tabun-inhibited AChE.
Journal of applied toxicology : JAT 2005;25(6):491-5.
2005: Musilek K; Kuca K; Jun D; Dohnal V; Dolezal M
Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase.
Journal of enzyme inhibition and medicinal chemistry 2005;20(5):409-15.
2005: Cabal J; Kuca K; Jun D; Bajgar J; Hrabinová M
[A comparison of the efficacy of the reactivators of acetylcholinesterase inhibited with tabun]
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2005;54(4):192-5.
2005: Dohnal V; Kuca K; Jun D
[Methods of artificial intelligence: a new trend in pharmacy]
Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti 2005;54(4):163-7.
2005: Kuca Kamil; Cabal Jiri; Jun Daniel; Kassa Jiri; Bartosová Lucie; Kunesová Gabriela
In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions.
Journal of applied toxicology : JAT 2005;25(4):296-300.
2005: Kuca Kamil; Cabal Jiri; Kassa Jiri; Jun Daniel; Hrabinová Martina
Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain.
Journal of applied toxicology : JAT 2005;25(4):271-6.
2005: Kuca Kamil; Bartosová Lucie; Jun Daniel; Patocka Jirí; Cabal Jirí; Kassa Jirí; Kunesová Gabriela
New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(1):75-82.
2005: Picha Jan; Kuca Kamil; Kivala Milan; Kohout Michal; Cabal Jiri; Liska Frantisek
A new group of monoquaternary reactivators of acetylcholinesterase inhibited by nerve agents.
Journal of enzyme inhibition and medicinal chemistry 2005;20(3):233-7.
2005: Kim Tae-Hyuk; Kuca Kamil; Jun Daniel; Jung Young-Sik
Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents.
Bioorganic & medicinal chemistry letters 2005;15(11):2914-7.
2005: Kuca Kamil; Cabal Jiri; Kassa Jiri
A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods.
Journal of toxicology and environmental health. Part A 2005;68(8):677-86.
2005: Sevelová Lucie; Kuca Kamil; Krejcová-Kunesová Gabriela
Antidotal treatment of GF-agent intoxication in mice with bispyridinium oximes.
Toxicology 2005;207(1):1-6.
2005: Kuca Kamil; Cabal Jirí; Kassa Jirí; Jun Daniel; Hrabinová Martina
A comparison of the potency of the oxime HLö-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2005;48(2):81-6.
2004: Kuca K; Cabal J; Kassa J
A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods.
Die Pharmazie 2004;59(10):795-8.
2004: Cabal Jirí; Kuca K; Kassa J
Specification of the structure of oximes able to reactivate tabun-inhibited acetylcholinesterase.
Basic & clinical pharmacology & toxicology 2004;95(2):81-6.
2004: Kuca Kamil; Kassa Jirí
Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent.
Human & experimental toxicology 2004;23(4):167-71.
2004: Kuca Kamil; Patocka Jirí
Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium--oximes.
Journal of enzyme inhibition and medicinal chemistry 2004;19(1):39-43.
2004: Kuca Kamil; Kassa Jirí
In vitro reactivation of acetylcholinesterase using the oxime K027.
Veterinary and human toxicology 2004;46(1):15-8.
2004: Bartosová Lucie; Kunesová Gabriela; Kuca Kamil; Vachek Josef
Therapeutic efficacy of different antidotal mixtures against poisoning with GF-agent in mice.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2004;47(4):249-51.
2004: Patocka Jirí; Kuca Kamil; Jun Daniel
Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2004;47(4):215-28.
2004: Kuca Kamil; Patocka Jirí; Cabal Jirí; Jun Daniel
Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes.
Neurotoxicity research 2004;6(7-8):565-70.
2004: Kuca Kamil; Dohnal Vlastimil
1,3-Bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2004;47(3):167-9.
2004: Cabal Jirí; Kuca Kamil; Sevelová-Bartosová Lucie; Dohnal Vlastimil
Cyclodextrines as functional agents for decontamination of the skin contaminated by nerve agents.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2004;47(2):115-8.
2004: Kuca Kamil; Sevelová-Bartosová Lucie; Krejcová-Kunesová Gabriela
In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 AND K048.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2004;47(2):107-9.
2003: Kuca K; Kassa J
A comparison of the ability of a new bispyridinium oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.
Journal of enzyme inhibition and medicinal chemistry 2003;18(6):529-35.
2003: Kuca Kamil; Bielavský Jirí; Cabal Jirí; Kassa Jirí
Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase.
Bioorganic & medicinal chemistry letters 2003;13(20):3545-7.

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