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Stefan Kuchen

Research Profile

Disorders

Rheumatoid Arthritis

Anatomy

Living Beings

Chemicals & Drugs

Physiology

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Publications

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Andrew L Snow; Louis M Staudt; Jeffrey R Stinson; Helen C Su; Wei Wang; Wenming Xiao; Lixin Zheng; Wei Lu; Helen F Matthews; Susan Moir; Stefania Pittaluga; Mark Raffeld; Roland Schmitz; Benjamin Chaigne-Delalande; Thomas A Fleisher; Sameer Jhavar; Huie Jing; Lela Kardava; Stefan Kuchen; Ian T Lamborn; Michael J Lenardo
Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.
Masaya Baba; Paul Bible; Carme Gallego Gonzalez; Hisashi Hasumi; Yukiko Hasumi; Robert M Hughes; Jonathan Keller; Kyong-Rim Kieffer-Kwon; Mara E Klein; Stefan Kuchen; W Marston Linehan; Hyoungbin F Oh; Wolfgang Resch; Laura S Schmidt; Eileen Southon; Hyung Chan Suh; Hong-Wei Sun; Lino Tessarollo; Rafael Casellas
The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development.
Hayato Takahashi; Lai Wei; Giuseppe Sciumè; Rafael Casellas; Kiyoshi Hirahara; Tomohiko Kanno; Yuka Kanno; Stefan Kuchen; Stefan A Muljo; Shingo Nakayamada; John J O'Shea
TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.

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All Publications

2012: Andrew L Snow; Louis M Staudt; Jeffrey R Stinson; Helen C Su; Wei Wang; Wenming Xiao; Lixin Zheng; Wei Lu; Helen F Matthews; Susan Moir; Stefania Pittaluga; Mark Raffeld; Roland Schmitz; Benjamin Chaigne-Delalande; Thomas A Fleisher; Sameer Jhavar; Huie Jing; Lela Kardava; Stefan Kuchen; Ian T Lamborn; Michael J Lenardo
Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.
The Journal of experimental medicine 2012;209(12):2247-61.
2012: Masaya Baba; Paul Bible; Carme Gallego Gonzalez; Hisashi Hasumi; Yukiko Hasumi; Robert M Hughes; Jonathan Keller; Kyong-Rim Kieffer-Kwon; Mara E Klein; Stefan Kuchen; W Marston Linehan; Hyoungbin F Oh; Wolfgang Resch; Laura S Schmidt; Eileen Southon; Hyung Chan Suh; Hong-Wei Sun; Lino Tessarollo; Rafael Casellas
The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development.
Blood 2012;120(6):1254-61.
2012: Hayato Takahashi; Lai Wei; Giuseppe Sciumè; Rafael Casellas; Kiyoshi Hirahara; Tomohiko Kanno; Yuka Kanno; Stefan Kuchen; Stefan A Muljo; Shingo Nakayamada; John J O'Shea
TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.
Nature immunology 2012;13(6):587-95.
2011: Arito Yamane; Wolfgang Resch; Nan Kuo; Stefan Kuchen; Zhiyu Li; Hong-Wei Sun; Davide F Robbiani; Kevin M McBride; Michel C Nussenzweig; Rafael Casellas
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes.
Nature immunology 2011;12(1):62-9.
2010: Stefan Kuchen; Wolfgang Resch; Arito Yamane; Nan Kuo; Zhiyu Li; Tirtha Chakraborty; Lai Wei; Arian Dominic John laurence; Tomoharu Yasuda; Siying Peng; Jane Hu-Li; Kristina Lu; Wendy Dubois; Yoshiaki Kitamura; Nicolas Charles; Hong-Wei Sun; Stefan Muljo; Pamela L Schwartzberg; William E Paul; John O'Shea; Klaus Rajewsky; Rafael Casellas
Regulation of microRNA expression and abundance during lymphopoiesis.
Immunity 2010;32(6):828-39.
2009: Lars Klemm; Duy Cihangir; Ilaria Iacobucci; Stefan Kuchen; Gregor von Levetzow; Niklas Feldhahn; Nadine Henke; Zhiyu Li; Thomas K Hoffmann; Yong Kim; Wolf-Karsten Hofmann; Hassan Jumaa; John Groffen; Nora Heisterkamp; Giovanni Martinelli; Michael R Lieber; Rafael Casellas; Markus Müschen
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.
Cancer cell 2009;16(3):232-45.
2009: Jisoo Lee; Stefan Kuchen; Randy Fischer; Sooghee Chang; Peter E Lipsky
Identification and characterization of a human CD5+ pre-naive B cell population.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4116-26.
2008: Catherine Rachel Ettinger; Stefan Kuchen; Peter E Lipsky
Interleukin 21 as a target of intervention in autoimmune disease.
Annals of the rheumatic diseases 2008;67 Suppl 3():iii83-6.
2008: Catherine Rachel Ettinger; Stefan Kuchen; Peter E Lipsky
The role of IL-21 in regulating B-cell function in health and disease.
Immunological reviews 2008;223():60-86.
2007: Stefan Kuchen; Rachel Robbins; Gary P Sims; Chen Sheng; Terence M Phillips; Peter E Lipsky; Catherine Rachel Ettinger
Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5886-96.
2007: Catherine Rachel Ettinger; Gary P Sims; Rachel Robbins; David Withers; Randy T Fischer; Amrie C Grammer; Stefan Kuchen; Peter E Lipsky
IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2872-82.
2007: Stefan Kuchen; Christian A Seemayer; Michel Neidhart; Renate E Gay; Steffen Gay
In situ hybridization of synovial tissue.
Methods in molecular medicine 2007;135():65-75.
2004: Thomas Pap; Michael Nawrath; Jochen Heinrich; Magnus Bosse; Anja Baier; Klaus M Hummel; Peter Petrow; Stefan Kuchen; Beat A Michel; Renate E Gay; Ulf Müller-Ladner; Karin Moelling; Steffen Gay
Cooperation of Ras- and c-Myc-dependent pathways in regulating the growth and invasiveness of synovial fibroblasts in rheumatoid arthritis.
Arthritis and rheumatism 2004;50(9):2794-802.
2004: J T Studýnková; Stefan Kuchen; E Jeisy; Jörg Schedel; F Charvát; K Jarosová; H Sprott; M Matucci-Cerinic; Renate E Gay; Beat A Michel; Karel Pavelka; J Vencovský; Steffen Gay
The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis.
Clinical and experimental rheumatology 2004;22(4):395-402.
2004: Jörg Schedel; Christian A Seemayer; Thomas Pap; Michel Neidhart; Stefan Kuchen; Beat A Michel; Renate E Gay; Ulf Müller-Ladner; Steffen Gay; W Zacharias
Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis.
Gene therapy 2004;11(13):1040-7.
2004: Stefan Kuchen; Christian A Seemayer; Janine Rethage; Rebecca von Knoch; Peter Kuenzler; A Michel Beat; Renate E Gay; Steffen Gay; Michel Neidhart
The L1 retroelement-related p40 protein induces p38delta MAP kinase.
Autoimmunity 2004;37(1):57-65.
2003: Christian A Seemayer; Stefan Kuchen; Michel Neidhart; Peter Kuenzler; Veronika Rihosková; E Neumann; Martin Pruschy; Wilhelm K Aicher; Ulf Müller-Ladner; Renate E Gay; Beat A Michel; Gary S Firestein; Steffen Gay
p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion.
Annals of the rheumatic diseases 2003;62(12):1139-44.
2003: Shiro Ohshima; Stefan Kuchen; Christian A Seemayer; Diego Kyburz; Astrid Hirt; Stephanie Klinzing; Beat A Michel; Renate E Gay; Fu-Tong Liu; Steffen Gay; Michel Neidhart
Galectin 3 and its binding protein in rheumatoid arthritis.
Arthritis and rheumatism 2003;48(10):2788-95.
2003: Peter Kuenzler; Stefan Kuchen; Veronika Rihosková; Beat A Michel; Renate E Gay; Michel Neidhart; Steffen Gay; Christian A Seemayer
Induction of p16 at sites of cartilage invasion in the SCID mouse coimplantation model of rheumatoid arthritis.
Arthritis and rheumatism 2003;48(7):2069-73.
2003: Christian A Seemayer; Stefan Kuchen; Peter Kuenzler; Veronika Rihosková; Janine Rethage; Wilhelm K Aicher; Beat A Michel; Renate E Gay; Diego Kyburz; Michel Neidhart; Steffen Gay
Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis.
The American journal of pathology 2003;162(5):1549-57.
2003: Wilhelm K Aicher; Dorothea Alexander; Christian Haas; Stefan Kuchen; Axel Pagenstecher; Steffen Gay; Hans-Hartmut Peter; Hermann Eibel
Transcription factor early growth response 1 activity up-regulates expression of tissue inhibitor of metalloproteinases 1 in human synovial fibroblasts.
Arthritis and rheumatism 2003;48(2):348-59.
2002: Steffen Gay; Stefan Kuchen; Renate E Gay; Michel Neidhart
Cartilage destruction in rheumatoid arthritis.
Annals of the rheumatic diseases 2002;61 Suppl 2():ii87.
2001: Christian A Seemayer; Oliver Distler; Stefan Kuchen; Ulf Müller-Ladner; Beat A Michel; Michel Neidhart; Renate E Gay; Steffen Gay
[Rheumatoid arthritis: new developments in the pathogenesis with special reference to synovial fibroblasts].
Zeitschrift für Rheumatologie 2001;60(5):309-18.
2000: Michel Neidhart; Janine Rethage; Stefan Kuchen; P Künzler; R M Crowl; Michael E J Billingham; Renate E Gay; Steffen Gay
Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression.
Arthritis and rheumatism 2000;43(12):2634-47.
2000: Stefan Kuchen; T Pap; Ulf Müller-Ladner; Renate E Gay; Steffen Gay
Gene transfer in rheumatoid arthritis: a novel therapeutic approach.
Clinical and experimental rheumatology 2000;18(5):543-5.
2000: Thomas Pap; Yukio Shigeyama; Stefan Kuchen; J K Fernihough; B Simmen; Renate E Gay; Michael E J Billingham; Steffen Gay
Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis.
Arthritis and rheumatism 2000;43(6):1226-32.
1999: Michel Neidhart; Stefan Kuchen; Oliver Distler; Pius Brühlmann; Beat A Michel; Renate E Gay; Steffen Gay
Increased serum levels of antibodies against human cytomegalovirus and prevalence of autoantibodies in systemic sclerosis.
Arthritis and rheumatism 1999;42(2):389-92.