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Raju Kucherlapati

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TOP 3
Changgong Li; Min Li; Ruoyun Ouyang; Makoto Mark Taketo; Yiming Xing; Zea Borok; Belinda Chan; Raju Kucherlapati; Aimin Li; Parviz Minoo
Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling.
Lixing Yang; Chengsheng Zhang; Alexei Protopopov; Xiaojia Ren; Ruibin Xi; Lynda Chin; Nils Gehlenborg; Psalm S Haseley; Chih-Heng Hsieh; Raju Kucherlapati; Charles Lee; Lovelace J Luquette; Peter J Park
Diverse mechanisms of somatic structural variations in human cancer genomes.
Rehan Akbani; Christopher C Benz; Andrew D Cherniack; Li Ding; Cyriac Kandoth; Raju Kucherlapati; Peter W Laird; Yuexin Liu; Elaine R Mardis; Gordon B Mills; Itai Pashtan; A Gordon Robertson; Nikolaus Schultz; Hui Shen; Ronglai Shen; Christina Yau; Wei Zhang; Douglas A Levine
Integrated genomic characterization of endometrial carcinoma.

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All Publications

2013: Changgong Li; Min Li; Ruoyun Ouyang; Makoto Mark Taketo; Yiming Xing; Zea Borok; Belinda Chan; Raju Kucherlapati; Aimin Li; Parviz Minoo
Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling.
Developmental biology 2013;378(1):13-24.
2013: Lixing Yang; Chengsheng Zhang; Alexei Protopopov; Xiaojia Ren; Ruibin Xi; Lynda Chin; Nils Gehlenborg; Psalm S Haseley; Chih-Heng Hsieh; Raju Kucherlapati; Charles Lee; Lovelace J Luquette; Peter J Park
Diverse mechanisms of somatic structural variations in human cancer genomes.
Cell 2013;153(4):919-29.
2013: Rehan Akbani; Christopher C Benz; Andrew D Cherniack; Li Ding; Cyriac Kandoth; Raju Kucherlapati; Peter W Laird; Yuexin Liu; Elaine R Mardis; Gordon B Mills; Itai Pashtan; A Gordon Robertson; Nikolaus Schultz; Hui Shen; Ronglai Shen; Christina Yau; Wei Zhang; Douglas A Levine
Integrated genomic characterization of endometrial carcinoma.
Nature 2013;497(7447):67-73.
2012: Rahul A Sheth; Mark Sinnamon; Lars Stangenberg; Kenneth E Hung; Raju Kucherlapati; Alexandra Kunin; Umar Mahmood
In vivo optical molecular imaging of matrix metalloproteinase activity following celecoxib therapy for colorectal cancer.
Molecular imaging 2012;11(5):417-25.
2012: Tatianna C Larman; Alexei Protopopov; Christine E Seidman; Lynda Chin; Steven R Depalma; Stacey B Gabriel; Angela G Hadjipanayis; Raju Kucherlapati; Jianhua Zhang; Jonathan G Seidman
Spectrum of somatic mitochondrial mutations in five cancers.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):14087-91.
2012: Eunjung Lee; Jens G Lohr; Lovelace J Luquette; Peter J Park; David A Wheeler; Richard K Wilson; Lixing Yang; Li Ding; Richard A Gibbs; Omer Gokcumen; Christopher C Harris; Psalm Haseley; Rebecca C Iskow; Peter V Kharchenko; Raju Kucherlapati; Charles Lee
Landscape of somatic retrotransposition in human cancers.
Science (New York, N.Y.) 2012;337(6097):967-71.
2012: Jon J Ladd; Paul D Lampe; Sharon J Pitteri; Ross L Prentice; Hong Wang; Qing Zhang; Dean E Brenner; Tina Busald; Ziding Feng; Melissa M Johnson; Raju Kucherlapati; Samir M Hanash
Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women.
Cancer prevention research (Philadelphia, Pa.) 2012;5(4):655-64.
2012: Raju Kucherlapati
Genetically modified mouse models for biomarker discovery and preclinical drug testing.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(3):625-30.
2012: Marina Kovalenko; Melanie H Kucherlapati; Raju Kucherlapati; Jong-Min Lee; Jaclyn New; Jason St Claire; Hualing Dong; Ella Dragileva; Michelle E Ehrlich; Tammy Gillis; Jolene R Guide; Vanessa C Wheeler
Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.
PloS one 2012;7(9):e44273.
2011: Takeshi Hiramoto; Gina Kang; Raju Kucherlapati; Yasushi Satoh; Go Suzuki; Yasuhiro Watanabe; Noboru Hiroi
Tbx1: identification of a 22q11.2 gene as a risk factor for autism spectrum disorder in a mouse model.
Human molecular genetics 2011;20(24):4775-85.
2011: Ruibin Xi; Jianhua Zhang; David A Wheeler; Richard A Gibbs; Angela G Hadjipanayis; Mark D Johnson; Tae-Min Kim; Raju Kucherlapati; Eunjung Lee; Lovelace J Luquette; Donna M Muzny; Peter J Park
Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(46):E1128-36.
2011: Ayumu Taguchi; Harold E Varmus; Chee-Hong Wong; Qing Zhang; Alice Chin; Ronald A DePinho; Daniela M Dinulescu; Vitor M Faça; Adi F Gazdar; Gary Goodman; Karen Kelly-Spratt; Christopher J Kemp; Raju Kucherlapati; William W Lockwood; Kwon-Sik Park; Sharon J Pitteri; Katerina Politi; Julien Sage; Samir M Hanash
Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.
Cancer cell 2011;20(3):289-99.
2011: Michael A McIlhatton; Jessica Tyler; Laura A Kerepesi; Tina Bocker-Edmonston; Melanie Haas Kucherlapati; Winfried Edelmann; Raju Kucherlapati; Levy Kopelovich; Richard Fishel
Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model.
Cancer prevention research (Philadelphia, Pa.) 2011;4(5):684-93.
2011: David A McDonald; Robert Shenkar; Changbin Shi; Rebecca A Stockton; Amy L Akers; Melanie Haas Kucherlapati; Raju Kucherlapati; James Brainer; Mark H Ginsberg; Issam A Awad; Douglas A Marchuk
A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.
Human molecular genetics 2011;20(2):211-22.
2010: Peng-Chieh Chen; Hiroko Wakimoto; David Conner; Toshiyuki Araki; Tao Yuan; Amy Roberts; Roderick Bronson; Jonathan G Seidman; Benjamin G Neel; Christine E Seidman; Raju Kucherlapati
Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.
The Journal of clinical investigation 2010;120(12):4353-65.
2010: Andrew T Chan; Yoshifumi Baba; Kaori Shima; Katsuhiko Nosho; Daniel C Chung; Kenneth E Hung; Umar Mahmood; Karen Madden; Kirtland Poss; Audrey Ranieri; Daniel Shue; Raju Kucherlapati; Charles S Fuchs; Shuji Ogino
Cathepsin B expression and survival in colon cancer: implications for molecular detection of neoplasia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010;19(11):2777-85.
2010: Raju Kucherlapati
Personalized medicine for non-small-cell lung cancer.
Oncology (Williston Park, N.Y.) 2010;24(5):399-400.
2010: Pilhan Kim; Euiheon Chung; Hiroshi Yamashita; Kenneth E Hung; Atsushi Mizoguchi; Raju Kucherlapati; Dai Fukumura; Rakesh K Jain; Seok H Yun
In vivo wide-area cellular imaging by side-view endomicroscopy.
Nature methods 2010;7(4):303-5.
2010: Yuxun Wang; Weijia Zhang; Lisa Edelmann; Richard D Kolodner; Raju Kucherlapati; Winfried Edelmann
Cis lethal genetic interactions attenuate and alter p53 tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(12):5511-5.
2010: Melanie Haas Kucherlapati; Kyeryoung Lee; Andrew A Nguyen; Alan B Clark; Harry Hou; Andrew Rosulek; Hua Li; Kan Yang; Kunhua Fan; Martin Lipkin; Roderick T Bronson; Linda Jelicks; Thomas A Kunkel; Raju Kucherlapati; Winfried Edelmann
An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.
Gastroenterology 2010;138(3):993-1002.e1.
2010: Icksoo Lee; Alena Pecinova; Petr Pecina; Benjamin G Neel; Toshiyuki Araki; Raju Kucherlapati; Amy E Roberts; Maik Huttemann
A suggested role for mitochondria in Noonan syndrome.
Biochimica et biophysica acta 2010;1802(2):275-83.
2010: Kenneth E Hung; Marco A Maricevich; Larissa Georgeon Richard; Wei Y Chen; Michael P Richardson; Alexandra Kunin; Roderick T Bronson; Umar Mahmood; Raju Kucherlapati
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(4):1565-70.
2009: Osamu Itano; Kan Yang; Kunhua Fan; Naoto Kurihara; Hiroharu Shinozaki; Sadanori Abe; Bo Jin; Claudia Gravaghi; Winfried Edelmann; Leonard H Augenlicht; Levy Kopelovich; Raju Kucherlapati; Sergio Lamprecht; Martin Lipkin
Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations.
Carcinogenesis 2009;30(11):1923-6.
2009: Katherine L Narr; Philip Szeszko; Todd Lencz; Roger P Woods; Liberty S Hamilton; Owen Phillips; Delbert Robinson; Katherine Burdick; Pamela DeRosse; Raju Kucherlapati; Paul M Thompson; Arthur W Toga; Anil Malhotra; Robert Bilder
DTNBP1 is associated with imaging phenotypes in schizophrenia.
Human brain mapping 2009;30(11):3783-94.
2009: Go Suzuki; Kathryn M Harper; Takeshi Hiramoto; Birgit Funke; MoonSook Lee; Gina Kang; Mahalah Buell; Mark A Geyer; Raju Kucherlapati; Bernice E Morrow; Pekka T Männistö; Soh Agatsuma; Noboru Hiroi
Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice.
Human molecular genetics 2009;18(20):3914-25.
2009: Daniel S Herman; G Kees Hovingh; Oleg Iartchouk; Heidi L Rehm; Raju Kucherlapati; Jonathan G Seidman; Christine E Seidman
Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection.
Nature methods 2009;6(7):507-10.
2009: Xiu-Ping Wang; Daniel J O'Connell; Jennifer J Lund; Irfan Saadi; Mari Kuraguchi; Annick Turbe-Doan; Resy Cavallesco; Hyunsoo Kim; Peter J Park; Hidemitsu Harada; Raju Kucherlapati; Richard L Maas
Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood.
Development (Cambridge, England) 2009;136(11):1939-49.
2009: Stéphane Vassilopoulos; Christopher Esk; Sachiko Hoshino; Benjamin Funke; Chih-Ying Chen; Alex M Plocik; Woodring E Wright; Raju Kucherlapati; Frances M Brodsky
A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.
Science (New York, N.Y.) 2009;324(5931):1192-6.
2009: Mai X Luong; Joshua Tam; Qingcong Lin; Jeroen Hagendoorn; Kathryn J Moore; Timothy P Padera; Brian Seed; Dai Fukumura; Raju Kucherlapati; Rakesh K Jain
Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.
Journal of cellular physiology 2009;219(2):430-7.
2009: Kenneth E Hung; Vitor Faca; Kenneth Song; David A Sarracino; Larissa Georgeon Richard; Bryan Krastins; Sara Forrester; Andrew Porter; Alexandra Kunin; Umar Mahmood; Brian B Haab; Samir M Hanash; Raju Kucherlapati
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Cancer prevention research (Philadelphia, Pa.) 2009;2(3):224-33.
2009: Mari Kuraguchi; Nana Yaw Ohene-Baah; Dmitriy Sonkin; Roderick T Bronson; Raju Kucherlapati
Genetic mechanisms in Apc-mediated mammary tumorigenesis.
PLoS genetics 2009;5(2):e1000367.
2008: Melanie Haas Kucherlapati; Kan Yang; Kunhua Fan; Mari Kuraguchi; Dmitriy Sonkin; Andrew Rosulek; Martin Lipkin; Roderick T Bronson; Bruce Aronow; Raju Kucherlapati
Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15493-8.
2008: Kate T Montgomery; Oleg Iartchouck; Li Li; Stephanie Loomis; Vanessa Obourn; Raju Kucherlapati
PolyPhred analysis software for mutation detection from fluorescence-based sequence data.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2008;Chapter 7():Unit 7.16.
2008: Kan Yang; Sergio A Lamprecht; Hiroharu Shinozaki; Kunhua Fan; Wancai Yang; Harold L Newmark; Levy Kopelovich; Winfried Edelmann; Bo Jin; Claudia Gravaghi; Leonard H Augenlicht; Raju Kucherlapati; Martin Lipkin
Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice.
The Journal of nutrition 2008;138(9):1658-63.
2008: Julio Barrera-Oro; Tzu-Yang Liu; Erin Gorden; Raju Kucherlapati; Changshun Shao; Jay A Tischfield
Role of the mismatch repair gene, Msh6, in suppressing genome instability and radiation-induced mutations.
Mutation research 2008;642(1-2):74-9.
2008: Peng-Chieh Chen; Mari Kuraguchi; John Velasquez; Yuxun Wang; Kan Yang; Robert Edwards; Dan Gillen; Winfried Edelmann; Raju Kucherlapati; Steven M Lipkin
Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.
PLoS genetics 2008;4(6):e1000092.
2008: Victoria A Joshi; Raju Kucherlapati
Genetics and genomics in the practice of medicine.
Gastroenterology 2008;134(5):1284-8.
2008: Hiroyuki Morita; Heidi L Rehm; Andres Menesses; Barbara McDonough; Amy E Roberts; Raju Kucherlapati; Jeffrey A Towbin; Jonathan G Seidman; Christine E Seidman
Shared genetic causes of cardiac hypertrophy in children and adults.
The New England journal of medicine 2008;358(18):1899-908.
2008: Kate T Montgomery; Oleg Iartchouck; Li Li; Anoja Perera; Yosuf Yassin; Alex Tamburino; Stephanie Loomis; Raju Kucherlapati
Mutation detection using automated fluorescence-based sequencing.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2008;Chapter 7():Unit7.9.
2008: Rita A Busuttil; Qingcong Lin; Peter J Stambrook; Raju Kucherlapati; Jan Vijg
Mutation frequencies and spectra in DNA polymerase eta-deficient mice.
Cancer research 2008;68(7):2081-4.
2008: Elena Avdievich; Cora Reiss; Stefan J Scherer; Yongwei Zhang; Sandra M Maier; Bo Jin; Harry Hou; Andreas Rosenwald; Hubertus Riedmiller; Raju Kucherlapati; Paula E Cohen; Winfried Edelmann; Burkhard Kneitz
Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4247-52.
2008: Kenneth D Swanson; Jordan M Winter; Marcelo Reis; Mohamed Bentires-Alj; Heidi Greulich; Rupinder Grewal; Ralph Hruban; Charles J Yeo; Yosuf Yassin; Oleg Iartchouk; Kate Montgomery; Susan P Whitman; Michael A Caligiuri; Mignon L Loh; D Gary Gilliland; A Thomas Look; Raju Kucherlapati; Scott E Kern; Matthew Meyerson; Benjamin G Neel
SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients.
Genes, chromosomes & cancer 2008;47(3):253-9.
2008: Qing Zhang; Rajasree Menon; Eric W Deutsch; Sharon J Pitteri; Vitor M Faca; Hong Wang; Lisa F Newcomb; Ronald A DePinho; Nabeel Bardeesy; Daniela M Dinulescu; Kenneth E Hung; Raju Kucherlapati; Tyler Jacks; Katerina Politi; Ruedi Aebersold; Gilbert S Omenn; David States; Samir M Hanash
A mouse plasma peptide atlas as a resource for disease proteomics.
Genome biology 2008;9(6):R93.
2007: Todd Lencz; Christophe Lambert; Pamela DeRosse; Katherine Burdick; T Vance Morgan; John M Kane; Raju Kucherlapati; Anil Malhotra
Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19942-7.
2007: Eric S Martin; Giovanni Tonon; Raktim Sinha; Yonghong Xiao; Bin Feng; Alec C Kimmelman; Alexei Protopopov; Elena Ivanova; Cameron Brennan; Kate Montgomery; Raju Kucherlapati; Gerald Bailey; Mark Redston; Lynda Chin; Ronald A DePinho
Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.
Cancer research 2007;67(22):10736-43.
2007: Melanie Haas Kucherlapati; A Nguyen; Mari Kuraguchi; Kan Yang; Kunhua Fan; R Bronson; K Wei; Martin Lipkin; Winfried Edelmann; Raju Kucherlapati
Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies.
Oncogene 2007;26(43):6297-306.
2007: Sara Forrester; Kenneth E Hung; Rork Kuick; Raju Kucherlapati; Brian B Haab
Low-volume, high-throughput sandwich immunoassays for profiling plasma proteins in mice: identification of early-stage systemic inflammation in a mouse model of intestinal cancer.
Molecular oncology 2007;1(2):216-25.
2007: Victoria A Joshi; Raju Kucherlapati
Pharmacogenomics of lung cancer: with a view to address EGFR-targeted therapies.
Pharmacogenomics 2007;8(9):1211-20.
2007: Birgit Funke; Todd Lencz; Christine T Finn; Pamela DeRosse; G David Poznik; Alex M Plocik; John M Kane; John J Rogus; Anil Malhotra; Raju Kucherlapati
Analysis of TBX1 variation in patients with psychotic and affective disorders.
Molecular medicine (Cambridge, Mass.) 2007;13(7-8):407-14.
2007: Katherine Burdick; Birgit Funke; Joseph F Goldberg; John A Bates; Judith Jaeger; Raju Kucherlapati; Anil Malhotra
COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance.
Bipolar disorders 2007;9(4):370-6.
2007: Christian P Kratz; Charlotte M Niemeyer; C Thomas; S Bauhuber; Verena Matejas; Eva Bergsträsser; Christian Flotho; N J Flores; Oskar A Haas; Henrik Hasle; Marry M van den Heuvel-Eibrink; Raju Kucherlapati; Peter Lang; Amy E Roberts; Jan Starý; Brigitte Strahm; Kenneth D Swanson; Monika M Trebo; Marco Zecca; Benjamin G Neel; Franco Locatelli; Mignon L Loh; Martin Zenker
Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemia.
Leukemia 2007;21(5):1108-9.
2007: Raju Kucherlapati
Raju Kucherlapati talks about personalised medicine: breathing new life into old drugs. Interview by Steve Carney.
Drug discovery today 2007;12(7-8):272-5.
2007: Birgit Funke; Alison C Brown; Marco F Ramoni; Maura E Regan; Chris Baglieri; Christine T Finn; Melanie Babcock; Robert J Shprintzen; Bernice E Morrow; Raju Kucherlapati
A novel, single nucleotide polymorphism-based assay to detect 22q11 deletions.
Genetic testing 2007;11(1):91-100.
2007: Lecia V Sequist; Victoria A Joshi; Pasi A Janne; Alona Muzikansky; Panos Fidias; Matthew Meyerson; Daniel A Haber; Raju Kucherlapati; Bruce E Johnson; Thomas J Lynch
Response to treatment and survival of patients with non-small cell lung cancer undergoing somatic EGFR mutation testing.
The oncologist 2007;12(1):90-8.
2007: Amy E Roberts; Toshiyuki Araki; Kenneth D Swanson; Kate T Montgomery; Taryn A Schiripo; Victoria A Joshi; Li Li; Yosuf Yassin; Alex M Tamburino; Benjamin G Neel; Raju Kucherlapati
Germline gain-of-function mutations in SOS1 cause Noonan syndrome.
Nature genetics 2007;39(1):70-4.
2007: Katherine Burdick; Terry Goldberg; Birgit Funke; John A Bates; Todd Lencz; Raju Kucherlapati; Anil Malhotra
DTNBP1 genotype influences cognitive decline in schizophrenia.
Schizophrenia research 2007;89(1-3):169-72.
2006: Chad A Dumstorf; Alan B Clark; Qingcong Lin; Grace E Kissling; Tao Yuan; Raju Kucherlapati; W Glenn McGregor; Thomas A Kunkel
Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(48):18083-8.
2006: Jeffrey M Long; Patricia LaPorte; Sandra Merscher-gomez; Birgit Funke; Bruno Saint-Jore; Anne Puech; Raju Kucherlapati; Bernice E Morrow; Arthur I Skoultchi; Anthony Wynshaw-Boris
Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome.
Neurogenetics 2006;7(4):247-57.
2006: Pamela DeRosse; Birgit Funke; Katherine Burdick; Todd Lencz; Terry Goldberg; John M Kane; Raju Kucherlapati; Anil Malhotra
COMT genotype and manic symptoms in schizophrenia.
Schizophrenia research 2006;87(1-3):28-31.
2006: Mari Kuraguchi; Xiu-Ping Wang; Roderick T Bronson; Rebecca Rothenberg; Nana Yaw Ohene-Baah; Jennifer J Lund; Melanie Haas Kucherlapati; Richard L Maas; Raju Kucherlapati
Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.
PLoS genetics 2006;2(9):e146.
2006: Kenneth E Hung; Alvin T Kho; David A Sarracino; Larissa Georgeon Richard; Bryan Krastins; Sara Forrester; Brian B Haab; Isaac S Kohane; Raju Kucherlapati
Mass spectrometry-based study of the plasma proteome in a mouse intestinal tumor model.
Journal of proteome research 2006;5(8):1866-78.
2006: Lecia V Sequist; Victoria A Joshi; Pasi A Janne; Daphne W Bell; Panos Fidias; Neal Lindeman; David N Louis; Jeffrey C Lee; Eugene J Mark; Janina Longtine; Peter Verlander; Raju Kucherlapati; Matthew Meyerson; Daniel A Haber; Bruce E Johnson; Thomas J Lynch
Epidermal growth factor receptor mutation testing in the care of lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 2):4403s-4408s.
2006: Katherine Burdick; Todd Lencz; Birgit Funke; Christine T Finn; Philip Szeszko; John M Kane; Raju Kucherlapati; Anil Malhotra
Genetic variation in DTNBP1 influences general cognitive ability.
Human molecular genetics 2006;15(10):1563-8.
2006: Wendy R Kates; Kevin M Antshel; Nuria AbdulSabur; Deirdre Colgan; Birgit Funke; Wanda Fremont; Anne Marie Higgins; Raju Kucherlapati; Robert J Shprintzen
A gender-moderated effect of a functional COMT polymorphism on prefrontal brain morphology and function in velo-cardio-facial syndrome (22q11.2 deletion syndrome).
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(3):274-80.
2006: Melanie Haas Kucherlapati; Andrew A Nguyen; Roderick T Bronson; Raju Kucherlapati
Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract.
Cancer research 2006;66(7):3576-83.
2006: Jeroen Hagendoorn; Ricky Tong; Dai Fukumura; Qingcong Lin; Jennifer Lobo; Timothy P Padera; Lei Xu; Raju Kucherlapati; Rakesh K Jain
Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Cancer research 2006;66(7):3360-4.
2006: Pamela DeRosse; Birgit Funke; Katherine Burdick; Todd Lencz; Jenny M Ekholm; John M Kane; Raju Kucherlapati; Anil Malhotra
Dysbindin genotype and negative symptoms in schizophrenia.
The American journal of psychiatry 2006;163(3):532-4.
2006: Jennifer L Moran; Andrew D Bolton; Pamela V Tran; Alison Brown; Noelle D Dwyer; Danielle K Manning; Bryan Bjork; Cheng Li; Kate Montgomery; Sandra M Siepka; Martha Hotz Vitaterna; Joseph S Takahashi; Timothy Wiltshire; David J Kwiatkowski; Raju Kucherlapati; David Beier
Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.
Genome research 2006;16(3):436-40.
2006: Jörg Klein; Wenjun Ju; Joerg Heyer; Britta Wittek; Torsten Haneke; Petra Knaus; Raju Kucherlapati; Erwin P Böttinger; Lars Nitschke; Burkhard Kneitz
B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-beta-directed IgA switching and changes in B cell fate.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2389-96.
2006: Daniel G Lee; Jonathan M Urbach; Gang Wu; Nicole T Liberati; Rhonda Feinbaum; Sachiko Miyata; Lenard T Diggins; Jianxin He; Maude Saucier; Eric Déziel; Lisa Friedman; Li Li; George Grills; Kate Montgomery; Raju Kucherlapati; Laurence G Rahme; Frederick M Ausubel
Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial.
Genome biology 2006;7(10):R90.
2006: Qingcong Lin; Alan B Clark; Scott D McCulloch; Tao Yuan; Roderick T Bronson; Thomas A Kunkel; Raju Kucherlapati
Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice.
Cancer research 2006;66(1):87-94.
2006: Wenjun Ju; Atsushi Ogawa; Joerg Heyer; Dirk Nierhof; Liping Yu; Raju Kucherlapati; David A Shafritz; Erwin P Böttinger
Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation.
Molecular and cellular biology 2006;26(2):654-67.
2005: Noboru Hiroi; Hongwen Zhu; MoonSook Lee; Birgit Funke; Makoto Arai; Masanari Itokawa; Raju Kucherlapati; Bernice E Morrow; Takehito Sawamura; Soh Agatsuma
A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19132-7.
2005: Birgit Funke; Anil Malhotra; Christine T Finn; Alex M Plocik; Stephen L Lake; Todd Lencz; Pamela DeRosse; John M Kane; Raju Kucherlapati
COMT genetic variation confers risk for psychotic and affective disorders: a case control study.
Behavioral and brain functions : BBF 2005;1():19.
2005: Shelly Ziv; Ori Brenner; Ninette Amariglio; Nechama I Smorodinsky; Ronit Galron; Danaise V Carrion; Weijia Zhang; Girdhar G Sharma; Raj K Pandita; Manjula Agarwal; Ran Elkon; Nirit Katzin; Irit Bar-Am; Tej K Pandita; Raju Kucherlapati; Gideon Rechavi; Yosef Shiloh; Ari Barzilai
Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.
Human molecular genetics 2005;14(19):2929-43.
2005: Mark Zervas; Thoralf Opitz; Winfried Edelmann; Bruce Wainer; Raju Kucherlapati; Patric Stanton
Impaired hippocampal long-term potentiation in microtubule-associated protein 1B-deficient mice.
Journal of neuroscience research 2005;82(1):83-92.
2005: Weil R Lai; Mark D Johnson; Raju Kucherlapati; Peter J Park
Comparative analysis of algorithms for identifying amplifications and deletions in array CGH data.
Bioinformatics (Oxford, England) 2005;21(19):3763-70.
2005: Kan Yang; Kun-Hua Fan; Sergio A Lamprecht; Winfried Edelmann; Levy Kopelovich; Raju Kucherlapati; Martin Lipkin
Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice.
International journal of cancer. Journal international du cancer 2005;116(4):495-9.
2005: Barbara A L Owen; Zungyoon Yang; Maoyi Lai; Maciej Gajec; Maciez Gajek; John D Badger; Jeffrey J Hayes; Winfried Edelmann; Raju Kucherlapati; Teresa M Wilson; Cynthia T McMurray
(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition.
Nature structural & molecular biology 2005;12(8):663-70.
2005: Yuxun Wang; Christopher D Putnam; Michael F Kane; Weijia Zhang; Lisa Edelmann; Robert Russell; Danaise V Carrión; Lynda Chin; Raju Kucherlapati; Richard D Kolodner; Winfried Edelmann
Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice.
Nature genetics 2005;37(7):750-5.
2005: Michelle Dziejman; Davide Serruto; Vincent C Tam; Derek Sturtevant; Pornphan Diraphat; Shah M Faruque; M Hasibur Rahman; John F Heidelberg; Jeremy Decker; Li Li; Kate T Montgomery; George Grills; Raju Kucherlapati; John J Mekalanos
Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3465-70.
2005: Amy E Roberts; Britta Hult; Heidi L Rehm; Heidi L Rehm; Barbara McDonough; Scott Barr; Christine E Seidman; Jonathan G Seidman; Raju Kucherlapati
The PTPN11 gene is not implicated in nonsyndromic hypertrophic cardiomyopathy.
American journal of medical genetics. Part A 2005;132A(3):333-4.
2004: Changshun Shao; Li Deng; Yanping Chen; Raju Kucherlapati; Peter J Stambrook; Jay A Tischfield
Mlh1 mediates tissue-specific regulation of mitotic recombination.
Oncogene 2004;23(56):9017-24.
2004: Birgit Funke; Christine T Finn; Alex M Plocik; Stephen L Lake; Pamela DeRosse; John M Kane; Raju Kucherlapati; Anil Malhotra
Association of the DTNBP1 locus with schizophrenia in a U.S. population.
American journal of human genetics 2004;75(5):891-8.
2004: Guohze Yang; Stefan J Scherer; Scarlet S Shell; Kan Yang; Mimi Y Kim; Martin Lipkin; Raju Kucherlapati; Richard D Kolodner; Winfried Edelmann
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility.
Cancer cell 2004;6(2):139-50.
2004: Diana P Lin; Yuxun Wang; Stefan J Scherer; Alan B Clark; Kan Yang; Elena Avdievich; Bo Jin; Uwe Werling; Tchaiko Parris; Naoto Kurihara; Asad Umar; Raju Kucherlapati; Martin Lipkin; Thomas A Kunkel; Winfried Edelmann
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis.
Cancer research 2004;64(2):517-22.
2003: Omar Kabbarah; Mary Ann Mallon; John D Pfeifer; Winfried Edelmann; Raju Kucherlapati; Paul J Goodfellow
A panel of repeat markers for detection of microsatellite instability in murine tumors.
Molecular carcinogenesis 2003;38(4):155-9.
2003: Theresa P Pretlow; Winfried Edelmann; Raju Kucherlapati; Thomas G Pretlow; Leonard H Augenlicht
Spontaneous aberrant crypt foci in Apc1638N mice with a mutant Apc allele.
The American journal of pathology 2003;163(5):1757-63.
2003: Leah C Young; Anthea C Peters; Tomoko Maeda; Winfried Edelmann; Raju Kucherlapati; Susan E Andrew; Victor A Tron
DNA mismatch repair protein Msh6 is required for optimal levels of ultraviolet-B-induced apoptosis in primary mouse fibroblasts.
The Journal of investigative dermatology 2003;121(4):876-80.
2003: Yaw-Ching Yang; Ester Piek; Jiri Zavadil; Dan Liang; Donglu Xie; Joerg Heyer; Paul Pavlidis; Raju Kucherlapati; Anita B Roberts; Erwin P Böttinger
Hierarchical model of gene regulation by transforming growth factor beta.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10269-74.
2003: Chiaki Takahashi; Roderick T Bronson; Merav Socolovsky; Bernardo Contreras; Kwang Youl Lee; Tyler Jacks; Makoto Noda; Raju Kucherlapati; Mark E Ewen
Rb and N-ras function together to control differentiation in the mouse.
Molecular and cellular biology 2003;23(15):5256-68.
2003: Hiroharu Shinozaki; Kan Yang; Kunhua Fan; Winfried Edelmann; Raju Kucherlapati; I Bernard Weinstein; Martin Lipkin
Cyclin D1 expression in the intestinal mucosa and tumors of Apc1638N mice.
Anticancer research 2003;23(3B):2217-26.
2003: Suroj Supavekin; Weijia Zhang; Raju Kucherlapati; Frederick J Kaskel; Leon C Moore; Prasad Devarajan
Differential gene expression following early renal ischemia/reperfusion.
Kidney international 2003;63(5):1714-24.
2003: Kan Yang; Kunhua Fan; Naoto Kurihara; Hiroharu Shinozaki; Basil Rigas; Leonard H Augenlicht; Levy Kopelovich; Winfried Edelmann; Raju Kucherlapati; Martin Lipkin
Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations.
Carcinogenesis 2003;24(3):605-11.
2002: Veronique Bourdon; Felix Naef; Pulivarthi H Rao; Victor E Reuter; Samuel C Mok; George J Bosl; Sanjay Koul; Vundavalli Murty; Raju Kucherlapati; Raju S K Chaganti
Genomic and expression analysis of the 12p11-p12 amplicon using EST arrays identifies two novel amplified and overexpressed genes.
Cancer research 2002;62(21):6218-23.
2002: Lazaros Kochilas; Sandra Merscher-gomez; Min Min Lu; Vijaya Potluri; Jun Liao; Raju Kucherlapati; Bernice E Morrow; Jonathan A Epstein
The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome.
Developmental biology 2002;251(1):157-66.
2002: Geoffrey D Girnun; Wendy M Smith; Stavit Drori; pasha sarraf; Elisabetta Mueller; Charis Eng; Prashant R Nambiar; Daniel W Rosenberg; Roderick T Bronson; Winfried Edelmann; Raju Kucherlapati; Frank J Gonzalez; Bruce M Spiegelman
APC-dependent suppression of colon carcinogenesis by PPARgamma.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13771-6.
2002: Melanie Haas Kucherlapati; Kan Yang; Mari Kuraguchi; Jie Zhao; Mariel Lia; Joerg Heyer; Michael F Kane; Kunhua Fan; Robert Russell; Anthony M C Brown; Burkhard Kneitz; Winfried Edelmann; Richard D Kolodner; Martin Lipkin; Raju Kucherlapati
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9924-9.
2002: Kaichun Wei; Raju Kucherlapati; Winfried Edelmann
Mouse models for human DNA mismatch-repair gene defects.
Trends in molecular medicine 2002;8(7):346-53.
2002: Björn Fritz; Falk Schubert; Gunnar Wrobel; Carsten Schwaenen; Swen Wessendorf; Michelle Nessling; Christian Korz; Ralf J Rieker; Kate Montgomery; Raju Kucherlapati; Gunhild Mechtersheimer; Roland Eils; Stefan Joos; Peter Lichter
Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma.
Cancer research 2002;62(11):2993-8.
2002: Marco Tartaglia; Kamini Kalidas; Adam Shaw; Xiaoling Song; Dan L Musat; Ineke van der Burgt; Han G Brunner; Débora R Bertola; Andrew H Crosby; Andra Ion; Raju Kucherlapati; Steve Jeffery; Michael A Patton; Bruce D Gelb
PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity.
American journal of human genetics 2002;70(6):1555-63.
2002: Kartiki V Desai; Nianqing Xiao; Weili Wang; Lisa Gangi; John Greene; John I Powell; Robert Dickson; Priscilla A Furth; Kent Hunter; Raju Kucherlapati; Richard Simon; Edison Liu; Jeffrey E Green
Initiating oncogenic event determines gene-expression patterns of human breast cancer models.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6967-72.
2002: Hong Wang; Wayne Douglas; Mariel Lia; Winfried Edelmann; Raju Kucherlapati; Katrina Podsypanina; Ramon Parsons; Lora Hedrick Ellenson
DNA mismatch repair deficiency accelerates endometrial tumorigenesis in Pten heterozygous mice.
The American journal of pathology 2002;160(4):1481-6.
2002: Anna Velcich; Wancai Yang; Joerg Heyer; Alessandra Fragale; Courtney Nicholas; Stephanie Viani; Raju Kucherlapati; Martin Lipkin; Kan Yang; Leonard H Augenlicht
Colorectal cancer in mice genetically deficient in the mucin Muc2.
Science (New York, N.Y.) 2002;295(5560):1726-9.
2002: Rui M Costa; Nikolai B Federov; Jeff H Kogan; Geoffrey G Murphy; Joel Stern; MASUO OHNO; Raju Kucherlapati; Tyler Jacks; Alcino J Silva
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1.
Nature 2002;415(6871):526-30.
2001: Marco Tartaglia; Ernest L Mehler; R Goldberg; Giuseppe Zampino; Han G Brunner; Hannie Kremer; Ineke van der Burgt; Andrew H Crosby; Andra Ion; Steve Jeffery; Kamini Kalidas; Michael A Patton; Raju Kucherlapati; Bruce D Gelb
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome.
Nature genetics 2001;29(4):465-8.
2001: Mari Kuraguchi; Kan Yang; Edmund Wong; Elena Avdievich; Kunhua Fan; Richard D Kolodner; Martin Lipkin; Anthony M C Brown; Raju Kucherlapati; Winfried Edelmann
The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis.
Cancer research 2001;61(21):7934-42.
2001: Wancai Yang; Anna Velcich; John M Mariadason; Courtney Nicholas; Georgia A Corner; Michele A Houston; Winfried Edelmann; Raju Kucherlapati; P R Holt; Leonard H Augenlicht
p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo.
Cancer research 2001;61(16):6297-302.
2001: Ester Piek; Wenjun Ju; Joerg Heyer; Diana Escalante-Alcalde; Colin L Stewart; M Weinstein; Chuxia Deng; Raju Kucherlapati; Erwin P Bottinger; Anita B Roberts
Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts.
The Journal of biological chemistry 2001;276(23):19945-53.
2001: Raju Kucherlapati; Diana P Lin; Winfried Edelmann
Mouse models for human familial adenomatous polyposis.
Seminars in cancer biology 2001;11(3):219-25.
2001: Sandra Merscher-gomez; Birgit Funke; Jonathan A Epstein; Joerg Heyer; Anne Puech; M M Lu; R J Xavier; M B Demay; R G Russell; Stephen M Factor; K Tokooya; B S Jore; M Lopez; RK Pandita; Mariel Lia; D Carrion; H Xu; Hubert Schorle; J B Kobler; Peter J Scambler; Anthony Wynshaw-Boris; Arthur I Skoultchi; Bernice E Morrow; Raju Kucherlapati
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome.
Cell 2001;104(4):619-29.
2001: Kate T Montgomery; E Lee; A Miller; S Lau; C Shim; J Decker; D Chiu; S Emerling; Mandeep Sekhon; R Kim; Jack Lenz; J Han; Ilya P Ioshikhes; B Renault; I Marondel; S J Yoon; K Song; Vundavalli Murty; S Scherer; Raluca Yonescu; Ilan R Kirsch; Thomas Ried; John McPherson; Richard Gibbs; Raju Kucherlapati
A high-resolution map of human chromosome 12.
Nature 2001;409(6822):945-6.
2001: Wancai Yang; J Mathew; Anna Velcich; Winfried Edelmann; Raju Kucherlapati; Martin Lipkin; K Yang; Leonard H Augenlicht
Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal.
Cancer research 2001;61(2):565-9.
2000: Mari Kuraguchi; Winfried Edelmann; Kan Yang; Martin Lipkin; Raju Kucherlapati; Anthony M C Brown
Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency.
Oncogene 2000;19(50):5755-63.
2000: Andra Ion; Andrew H Crosby; Hannie Kremer; N Kenmochi; M van Reen; CD Fenske; Ineke van der Burgt; Han G Brunner; K Montgomery; Raju Kucherlapati; Michael A Patton; C Page; Edwin C M Mariman; Steve Jeffery
Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2, DCN, EPS8, and RPL6.
Journal of medical genetics 2000;37(11):884-6.
2000: Ron Smits; N Hofland; Winfried Edelmann; Marjan Geugien; Shantie Jagmohan-Changur; Cristina Albuquerque; Cor Breukel; Raju Kucherlapati; Menno F Kielman; Riccardo Fodde
Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity.
Genes, chromosomes & cancer 2000;29(3):229-39.
2000: Anne Puech; Bruno Saint-Jore; Sandra Merscher-gomez; R G Russell; D Cherif; H Sirotkin; H Xu; Stephen M Factor; Raju Kucherlapati; Arthur I Skoultchi
Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10090-5.
2000: S Bala; George Oliver; B Renault; K Montgomery; S Dutta; P Rao; Jane Houldsworth; Raju Kucherlapati; X Wang; Raju S K Chaganti; Vundavalli Murty
Genetic analysis of the APAF1 gene in male germ cell tumors.
Genes, chromosomes & cancer 2000;28(3):258-68.
2000: Burkhard Kneitz; Paula E Cohen; Elena Avdievich; Liyin Zhu; Michael F Kane; Harry Hou; Richard D Kolodner; Raju Kucherlapati; Jeffrey W Pollard; Winfried Edelmann
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice.
Genes & development 2000;14(9):1085-97.
2000: Winfried Edelmann; Asad Umar; Kan Yang; Joerg Heyer; Melanie Haas Kucherlapati; Mariel Lia; Burkhard Kneitz; Elena Avdievich; Kunhua Fan; Edmund Wong; G Crouse; Thomas A Kunkel; Martin Lipkin; Richard D Kolodner; Raju Kucherlapati
The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.
Cancer research 2000;60(4):803-7.
1999: Leonard H Augenlicht; GM Anthony; T L Church; Winfried Edelmann; Raju Kucherlapati; K Yang; Martin Lipkin; Barbara G Heerdt
Short-chain fatty acid metabolism, apoptosis, and Apc-initiated tumorigenesis in the mouse gastrointestinal mucosa.
Cancer research 1999;59(23):6005-9.
1999: Joerg Heyer; Diana Escalante-Alcalde; Mariel Lia; E Boettinger; Winfried Edelmann; Colin L Stewart; Raju Kucherlapati
Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12595-600.
1999: Joerg Heyer; Kan Yang; Martin Lipkin; Winfried Edelmann; Raju Kucherlapati
Mouse models for colorectal cancer.
Oncogene 1999;18(38):5325-33.
1999: Vundavalli Murty; K Montgomery; S Dutta; S Bala; B Renault; George J Bosl; Raju Kucherlapati; Raju S K Chaganti
A 3-Mb high-resolution BAC/PAC contig of 12q22 encompassing the 830-kb consensus minimal deletion in male germ cell tumors.
Genome research 1999;9(7):662-71.
1999: Ron Smits; Menno F Kielman; Cor Breukel; Chris Zurcher; K Neufeld; Shantie Jagmohan-Changur; N Hofland; J van Dijk; Raymond White; Winfried Edelmann; Raju Kucherlapati; PM Khan; Riccardo Fodde
Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development.
Genes & development 1999;13(10):1309-21.
1999: A Weiss; D McDonough; B Wertman; LJ Acakpo-Satchivi; K Montgomery; Raju Kucherlapati; Leslie A Leinwand; K Krauter
Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2958-63.
1999: Winfried Edelmann; Kan Yang; Mari Kuraguchi; Joerg Heyer; Mariel Lia; Burkhard Kneitz; Kunhua Fan; Anthony M C Brown; Martin Lipkin; Raju Kucherlapati
Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice.
Cancer research 1999;59(6):1301-7.
1999: Anavaj Sakuntabhai; Victor L Ruiz-Perez; S Carter; N Jacobsen; Susan Burge; S Monk; M Smith; Colin S Munro; M O'Donovan; N Craddock; Raju Kucherlapati; Jonathan L Rees; M Owen; G Mark Lathrop; Anthony P Monaco; Tom Strachan; Alain Hovnanian
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease.
Nature genetics 1999;21(3):271-7.
1999: Winfried Edelmann; Paula E Cohen; Burkhard Kneitz; N Winand; Mariel Lia; Joerg Heyer; Richard D Kolodner; Jeffrey W Pollard; Raju Kucherlapati
Mammalian MutS homologue 5 is required for chromosome pairing in meiosis.
Nature genetics 1999;21(1):123-7.
1999: Vivian G Cheung; Michael Morley; F Aguilar; Aldo Massimi; Raju Kucherlapati; Geoffrey Childs
Making and reading microarrays.
Nature genetics 1999;21(1 Suppl):15-9.
1998: Kan Yang; Winfried Edelmann; Kunhua Fan; K Lau; D Leung; H Newmark; Raju Kucherlapati; Martin Lipkin
Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis.
Cancer research 1998;58(24):5713-7.
1998: Bruno Saint-Jore; Anne Puech; Joerg Heyer; Q Lin; C Raine; Raju Kucherlapati; Arthur I Skoultchi
Goosecoid-like (Gscl), a candidate gene for velocardiofacial syndrome, is not essential for normal mouse development.
Human molecular genetics 1998;7(12):1841-9.
1998: S L Ness; Winfried Edelmann; TD Jenkins; Wolfgang Liedtke; Anil K Rustgi; Raju Kucherlapati
Mouse keratin 4 is necessary for internal epithelial integrity.
The Journal of biological chemistry 1998;273(37):23904-11.
1998: Wolfgang Liedtke; Winfried Edelmann; Fungchow A Chiu; Raju Kucherlapati; Cedric S Raine
Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion.
The American journal of pathology 1998;152(1):251-9.
1997: Anne Puech; Bruno Saint-Jore; Birgit Funke; D J Gilbert; H Sirotkin; N G Copeland; N A Jenkins; Raju Kucherlapati; Bernice E Morrow; Arthur I Skoultchi
Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14608-13.
1997: Birgit Funke; Bruno Saint-Jore; Anne Puech; H Sirotkin; L Edelmann; C Carlson; S Raft; RK Pandita; Raju Kucherlapati; Arthur I Skoultchi; Bernice E Morrow
Characterization and mutation analysis of goosecoid-like (GSCL), a homeodomain-containing gene that maps to the critical region for VCFS/DGS on 22q11.
Genomics 1997;46(3):364-72.
1997: Y Sato; Stefan K Bohlander; H Kobayashi; SC Reshmi; Y Suto; Elizabeth M Davis; Rafael Espinosa; R Hoopes; Kate T Montgomery; Raju Kucherlapati; Michelle M Le Beau; Janet D Rowley
Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 in hematologic malignancies identified by fluorescence in situ hybridization: TEL (ETV6 ) is involved in only one half.
Blood 1997;90(12):4886-93.
1997: LJ Acakpo-Satchivi; Winfried Edelmann; CA Sartorius; B D Lu; PA Wahr; simon simon watkins; Joseph M Metzger; Leslie A Leinwand; Raju Kucherlapati
Growth and muscle defects in mice lacking adult myosin heavy chain genes.
The Journal of cell biology 1997;139(5):1219-29.
1997: Winfried Edelmann; Kan Yang; Asad Umar; Joerg Heyer; K Lau; Kunhua Fan; Wolfgang Liedtke; Paula E Cohen; Michael F Kane; J R Lipford; N Yu; G F Crouse; Jeffrey W Pollard; Thomas A Kunkel; Martin Lipkin; Richard D Kolodner; Raju Kucherlapati
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility.
Cell 1997;91(4):467-77.
1997: B Renault; Alain Hovnanian; S Bryce; J J Chang; S Lau; Anavaj Sakuntabhai; S Monk; S Carter; C J Ross; J Pang; R Twells; S Chamberlain; Anthony P Monaco; Tom Strachan; Raju Kucherlapati
A sequence-ready physical map of a region of 12q24.1.
Genomics 1997;45(2):271-8.
1997: C Carlson; H Sirotkin; RK Pandita; R Goldberg; J McKie; R Wadey; S R Patanjali; SM Weissman; K Anyane-Yeboa; D Warburton; Peter J Scambler; Robert J Shprintzen; Raju Kucherlapati; Bernice E Morrow
Molecular definition of 22q11 deletions in 151 velo-cardio-facial syndrome patients.
American journal of human genetics 1997;61(3):620-9.
1997: H Sirotkin; Bernice E Morrow; Bruno Saint-Jore; Anne Puech; R Das Gupta; S R Patanjali; Arthur I Skoultchi; SM Weissman; Raju Kucherlapati
Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome.
Genomics 1997;42(2):245-51.
1997: H Sirotkin; H O'Donnell; R DasGupta; Stephanie Halford; B St Jore; Anne Puech; Satish Parimoo; Bernice E Morrow; Arthur I Skoultchi; SM Weissman; Peter J Scambler; Raju Kucherlapati
Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndrome.
Genomics 1997;41(1):75-83.
1997: C Carlson; Demitri F Papolos; RK Pandita; Gianni Faedda; S Veit; R Goldberg; Robert J Shprintzen; Raju Kucherlapati; Bernice E Morrow
Molecular analysis of velo-cardio-facial syndrome patients with psychiatric disorders.
American journal of human genetics 1997;60(4):851-9.
1997: Kan Yang; Winfried Edelmann; Kunhua Fan; K Lau; V R Kolli; Riccardo Fodde; PM Khan; Raju Kucherlapati; Martin Lipkin
A mouse model of human familial adenomatous polyposis.
The Journal of experimental zoology 1997;277(3):245-54.
1997: Ron Smits; Alex Kartheuser; Shantie Jagmohan-Changur; V Leblanc; Cor Breukel; A de Vries; Henk J van Kranen; J H J M van Krieken; S Williamson; Winfried Edelmann; Raju Kucherlapati; Riccardo Fodde
Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.
Carcinogenesis 1997;18(2):321-7.
1996: I Marondel; B Renault; J Lieman; D Ward; Raju Kucherlapati
Physical mapping of the human neurotensin gene (NTS) between markers D12S1444 and D12S81 on chromosome 12q21.
Genomics 1996;38(2):243-5.
1996: Demitri F Papolos; Gianni Faedda; S Veit; R Goldberg; Bernice E Morrow; Raju Kucherlapati; Robert J Shprintzen
Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder?
The American journal of psychiatry 1996;153(12):1541-7.
1996: Wolfgang Liedtke; Winfried Edelmann; Phyllis Bieri; Fungchow A Chiu; N J Cowan; Raju Kucherlapati; Cedric S Raine
GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination.
Neuron 1996;17(4):607-15.
1996: Herbert M Lachman; Bernice E Morrow; Robert J Shprintzen; S Veit; S S Parsia; Gianni Faedda; R Goldberg; Raju Kucherlapati; Demitri F Papolos
Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome.
American journal of medical genetics 1996;67(5):468-72.
1996: M Schoenberg Fejzo; H R Ashar; K S Krauter; W L Powell; M S Rein; Stanislawa Weremowicz; S J Yoon; Raju Kucherlapati; Kiran Chada; Cynthia C Morton
Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas.
Genes, chromosomes & cancer 1996;17(1):1-6.
1996: Winfried Edelmann; Paula E Cohen; M Kane; K Lau; Bernice E Morrow; S Bennett; Asad Umar; Thomas A Kunkel; G Cattoretti; Raju S K Chaganti; Jeffrey W Pollard; Richard D Kolodner; Raju Kucherlapati
Meiotic pachytene arrest in MLH1-deficient mice.
Cell 1996;85(7):1125-34.
1996: Winfried Edelmann; Raju Kucherlapati
Role of recombination enzymes in mammalian cell survival.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6225-7.
1996: D W Johnson; Jonathan N Berg; M A Baldwin; Carol J Gallione; I Marondel; S J Yoon; Timothy T Stenzel; M Speer; Margaret Pericak-Vance; A Diamond; Alan E Guttmacher; Charles E Jackson; L Attisano; Raju Kucherlapati; M E M Porteous; Douglas A Marchuk
Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2.
Nature genetics 1996;13(2):189-95.
1996: H Sirotkin; Bernice E Morrow; R DasGupta; R Goldberg; S R Patanjali; G Shi; Linda Cannizzaro; Robert J Shprintzen; S M Weissman; Raju Kucherlapati
Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome.
Human molecular genetics 1996;5(5):617-24.
1996: Winfried Edelmann; M Zervas; P Costello; L Roback; I Fischer; J A Hammarback; N Cowan; Peter Davies; B Wainer; Raju Kucherlapati
Neuronal abnormalities in microtubule-associated protein 1B mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1270-5.
1996: Martin Lipkin; K Yang; Winfried Edelmann; H Newmark; Kunhua Fan; Mauro Risio; Raju Kucherlapati
Inherited and acquired risk factors in colonic neoplasia and modulation by chemopreventive interventions.
Journal of cellular biochemistry. Supplement 1996;25():136-41.
1996: L Cupelli; B Renault; J Leblanc-Straceski; A Banks; D Ward; Raju Kucherlapati; K Krauter
Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene cluster to 12q21 by in situ hybridization and physical mapping of the locus between D12S350 and D12S106.
Cytogenetics and cell genetics 1996;72(2-3):250-1.
1995: B Renault; J Lieman; D Ward; K Krauter; Raju Kucherlapati
Localization of the human achaete-scute homolog gene (ASCL1) distal to phenylalanine hydroxylase (PAH) and proximal to tumor rejection antigen (TRA1) on chromosome 12q22-q23.
Genomics 1995;30(1):81-3.
1995: Perry L Miller; Prakash M Nadkarni; Kenneth K Kidd; K Cheung; David C Ward; A Banks; Patricia Bray-Ward; L Cupelli; V Herdman; I Marondel; K Montgomery; B Renault; S J Yoon; K S Krauter; Raju Kucherlapati
Internet-based support for bioscience research: a collaborative genome center for human chromosome 12.
Journal of the American Medical Informatics Association : JAMIA 1995;2(6):351-64.
1995: Elizabeth C Engle; I Marondel; W A Houtman; B de Vries; A Loewenstein; M Lazar; David C Ward; Raju Kucherlapati; Alan H Beggs
Congenital fibrosis of the extraocular muscles (autosomal dominant congenital external ophthalmoplegia): genetic homogeneity, linkage refinement, and physical mapping on chromosome 12.
American journal of human genetics 1995;57(5):1086-94.
1995: R L Davies; S J Yoon; J Weissenbach; D Ward; K Krauter; Raju Kucherlapati
Physical mapping of the human ELA1 gene between D12S361 and D12S347 on chromosome 12q13.
Genomics 1995;29(3):766-8.
1995: C Campbell; I Marondel; K Montgomery; K Krauter; Raju Kucherlapati
Unequal homologous recombination of human DNA on a yeast artificial chromosome.
Nucleic acids research 1995;23(18):3691-5.
1995: Elizabeth Lindsay; R Goldberg; V Jurecic; Bernice E Morrow; C Carlson; Raju Kucherlapati; Robert J Shprintzen; Antonio Baldini
Velo-cardio-facial syndrome: frequency and extent of 22q11 deletions.
American journal of medical genetics 1995;57(3):514-22.
1995: A M Sirotkin; Winfried Edelmann; G Cheng; A Klein-Szanto; Raju Kucherlapati; Arthur I Skoultchi
Mice develop normally without the H1(0) linker histone.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(14):6434-8.
1995: H Umanoff; Winfried Edelmann; A Pellicer; Raju Kucherlapati
The murine N-ras gene is not essential for growth and development.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1709-13.
1994: S J Yoon; J LeBlanc-Straceski; D Ward; K Krauter; Raju Kucherlapati
Organization of the human keratin type II gene cluster at 12q13.
Genomics 1994;24(3):502-8.
1994: H Kobayashi; K T Montgomery; Stefan K Bohlander; Chaker N Adra; B L Lim; Raju Kucherlapati; H Donis-Keller; M S Holt; Michelle M Le Beau; Janet D Rowley
Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases.
Blood 1994;84(10):3473-82.
1994: S A Carter; S D Bryce; Colin S Munro; E Healy; Rumaisa Bashir; J Weissenbach; J LeBlanc-Straceski; Raju Kucherlapati; A Stephenson; Jonathan L Rees
Linkage analyses in British pedigrees suggest a single locus for Darier disease and narrow the location to the interval between D12S105 and D12S129.
Genomics 1994;24(2):378-82.
1994: Florence Pedeutour; Sandra Merscher-gomez; E Durieux; K Montgomery; K Krauter; J P Clevy; G Barcelo; Raju Kucherlapati; Patrick Gaudray; Claude Turc-Carel
Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints.
Genomics 1994;22(3):512-8.
1994: Y M Chan; QC Yu; J LeBlanc-Straceski; A Christiano; L Pulkkinen; Raju Kucherlapati; J Uitto; Elaine Fuchs
Mutations in the non-helical linker segment L1-2 of keratin 5 in patients with Weber-Cockayne epidermolysis bullosa simplex.
Journal of cell science 1994;107 ( Pt 4)():765-74.
1994: J M LeBlanc-Straceski; K T Montgomery; H Kissel; Lewis C. Murtaugh; P Tsai; David C Ward; K S Krauter; Raju Kucherlapati
Twenty-one polymorphic markers from human chromosome 12 for integration of genetic and physical maps.
Genomics 1994;19(2):341-9.
1993: K T Montgomery; J M LeBlanc; P Tsai; J S McNinch; David C Ward; P J de Jong; Raju Kucherlapati; K S Krauter
Characterization of two chromosome 12 cosmid libraries and development of STSs from cosmids mapped by FISH.
Genomics 1993;17(3):682-93.
1993: R Das Gupta; Bernice E Morrow; I Marondel; Satish Parimoo; V L Goei; Jeffrey R Gruen; S Weissman; Arthur I Skoultchi; Raju Kucherlapati
An integrated approach for identifying and mapping human genes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4364-8.
1992: S J Yoon; S H Seiler; Raju Kucherlapati; Leslie A Leinwand
Organization of the human skeletal myosin heavy chain gene cluster.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):12078-82.
1991: C Campbell; R Gulati; A K Nandi; K Floy; P Hieter; Raju Kucherlapati
Generation of a nested series of interstitial deletions in yeast artificial chromosomes carrying human DNA.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5744-8.