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Vijay Kuchroo

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Chuan Wu; Sheng Xiao; Nir Yosef; Bing Zhu; Youjin Lee; Gopal Murugaiyan; Caroline Pot; Manu Rangachari; Theresa Thalhamer; Lionel Apetoh; Vijay K Kuchroo
Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation.
Nir Yosef; Rahul Satija; Arvind Shakya; Alex K Shalek; Dean Tantin; John J Trombetta; Chuan Wu; Sheng Xiao; Amit Awasthi; Mark Bix; Mathew L Coleman; Jellert T Gaublomme; David Gennert; Hulin Jin; Marsela Jorgolli; Katarzyna Karwacz; Vijay K Kuchroo; Youjin Lee; Diana Y Lu; Hongkun Park; Meenu R Pillai; Peter J Ratcliffe; Aviv Regev
Dynamic regulatory network controlling TH17 cell differentiation.
Chuan Wu; Sheng Xiao; Nir Yosef; Chen Zhu; Yasuhiro Kishi; Aviv Regev; Theresa Thalhamer; Vijay K Kuchroo
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.

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2013: Chuan Wu; Sheng Xiao; Nir Yosef; Bing Zhu; Youjin Lee; Gopal Murugaiyan; Caroline Pot; Manu Rangachari; Theresa Thalhamer; Lionel Apetoh; Vijay K Kuchroo
Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(19):7802-7.
2013: Nir Yosef; Rahul Satija; Arvind Shakya; Alex K Shalek; Dean Tantin; John J Trombetta; Chuan Wu; Sheng Xiao; Amit Awasthi; Mark Bix; Mathew L Coleman; Jellert T Gaublomme; David Gennert; Hulin Jin; Marsela Jorgolli; Katarzyna Karwacz; Vijay K Kuchroo; Youjin Lee; Diana Y Lu; Hongkun Park; Meenu R Pillai; Peter J Ratcliffe; Aviv Regev
Dynamic regulatory network controlling TH17 cell differentiation.
Nature 2013;496(7446):461-8.
2013: Chuan Wu; Sheng Xiao; Nir Yosef; Chen Zhu; Yasuhiro Kishi; Aviv Regev; Theresa Thalhamer; Vijay K Kuchroo
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.
Nature 2013;496(7446):513-7.
2013: Pushpa Jayaraman; Vijay K Kuchroo; Tomoyasu Nishimura; Heinz G Remold; Isabel Sada-Ovalle; Ana C Anderson; Samuel M Behar
IL-1β Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(8):4196-204.
2013: Andrew P R Sutherland; Nicole Joller; Vijay K Kuchroo; Sue M Liu; Monia Michaud; Michael J Grusby
IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(8):3977-84.
2013: Abul K Abbas; Christophe Benoist; Jeffrey A Bluestone; Daniel J Campbell; Sankar Ghosh; Shohei Hori; Shuiping Jiang; Vijay K Kuchroo; Diane Mathis; Maria Grazia Roncarolo; Alexander Rudensky; Shimon Sakaguchi; Ethan M Shevach; Dario A A Vignali; Steve F Ziegler
Regulatory T cells: recommendations to simplify the nomenclature.
Nature immunology 2013;14(4):307-8.
2013: Jihoon Chang; Vijay K Kuchroo; Laurence A Turka; Christopher M Borges; Patrick R Burkett; Cheong-Hee Chang
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(6):2270-5.
2013: Chenhui Wang; Ling Wu; Hui Xiao; Jarod A Zepp; Caini Liu; Bradley N Martin; Saurav Misra; Wenjun Ouyang; Katarzyna Bulek; Kevin D Bunting; Julie A Carman; Ashok Dongre; Ji Gao; Shujie Han; Tomasz Herjan; Zizhen Kang; Jennifer S Ko; Vijay K Kuchroo; Xiaoxia Li
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.
Nature immunology 2013;14(1):72-81.
2012: Savithri Balasubramanian; Benjamin D Humphreys; Satya Keerthi Kota; Vijay K Kuchroo; Terry B Strom
TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77.
Science signaling 2012;5(254):ra90.
2012: Youjin Lee; Anneli Peters; Francisco J Quintana; Aviv Regev; Raymond A Sobel; Chuan Wu; Sheng Xiao; Nir Yosef; Amit Awasthi; David A Hafler; Markus Kleinewietfeld; Sharon Kunder; Vijay K Kuchroo
Induction and molecular signature of pathogenic TH17 cells.
Nature immunology 2012;13(10):991-9.
2012: Vijay K Kuchroo; Amit Awasthi
Emerging new roles of Th17 cells.
European journal of immunology 2012;42(9):2211-4.
2012: Manu Rangachari; Kaori Sakuishi; Raymond A Sobel; Andrew Wakeham; Sheng Xiao; Chen Zhu; Marylyn M Addo; Ana C Anderson; Mathieu Angin; Andrew Chen; Edward A Greenfield; Jozsef Karman; Tak W Mak; Peter J McKinnon; Hitoshi Okada; Vijay K Kuchroo
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.
Nature medicine 2012;18(9):1394-400.
2012: Dario A A Vignali; Vijay K Kuchroo
IL-12 family cytokines: immunological playmakers.
Nature immunology 2012;13(8):722-8.
2012: Francisco J Quintana; Manu Rangachari; John Seavitt; Sheng Xiao; Ada Yeste; Chen Zhu; Evan J Burns; Katia Georgopoulos; Hulin Jin; Deepak Kumar; Meghan Nadeau; Vijay K Kuchroo
Aiolos promotes TH17 differentiation by directly silencing Il2 expression.
Nature immunology 2012;13(8):770-7.
2012: Sheng Xiao; Ada Yeste; Chen Zhu; Joseph V Bonventre; Craig R Brooks; Takaharu Ichimura; Sonia Petecka; Francisco J Quintana; Raymond A Sobel; Johanna M Sweere; Chuan Wu; Vijay K Kuchroo
Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(30):12105-10.
2012: Rachelle G Veenstra; Qing Zhou; Ana C Anderson; Ryan Flynn; Mitsuomi Hirashima; Vijay K Kuchroo; Derek Liu; Angela Panoskaltsis-Mortari; Terry B Strom; Patricia A Taylor; Bruce R Blazar
Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.
Blood 2012;120(3):682-90.
2012: Shipra Gupta; Vijay K Kuchroo; Rafael Larocca; Thomas B Thornley; Laurence A Turka; Wenda Gao; Terry B Strom
Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs.
The Journal of clinical investigation 2012;122(7):2395-404.
2012: Nicole Joller; Ana C Anderson; Anneli Peters; Vijay K Kuchroo
Immune checkpoints in central nervous system autoimmunity.
Immunological reviews 2012;248(1):122-39.
2012: Filiberto Cedeno-Laurent; Vijay K Kuchroo; Matthew Opperman; Steven Barthel; Charles J Dimitroff
Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(7):3127-37.
2012: Ana C Anderson; Rucha Chandwaskar; Bernhard Greve; David H Lee; Roselynn Rodriguez-Manzanet; Raymond A Sobel; Adam Solomon; Jenna M Sullivan; Vijay K Kuchroo
A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(5):2084-92.
2012: Aurélie Ambrosi; Vijole Dzikaite; Eric Herlenius; Vijay K Kuchroo; Jeongsook Park; Linn Strandberg; Marie Wahren-Herlenius
Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model.
Annals of the rheumatic diseases 2012;71(3):448-54.
2012: Kevin D Fowler; Vijay K Kuchroo; Arup K Chakraborty
A model for how signal duration can determine distinct outcomes of gene transcription programs.
PloS one 2012;7(3):e33018.
2011: Anneli Peters; Youjin Lee; Vijay K Kuchroo
The many faces of Th17 cells.
Current opinion in immunology 2011;23(6):702-6.
2011: Caroline Pot; Lionel Apetoh; Amit Awasthi; Vijay K Kuchroo
Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27.
Seminars in immunology 2011;23(6):438-45.
2011: Shalini Sharma; Aarthi Sundararajan; Amol Suryawanshi; Paul Thomas; Tamara Veiga-Parga; Vijay K Kuchroo; Naveen Kumar; Mark Y Sangster; Barry T Rouse
T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(47):19001-6.
2011: Sue M Liu; Nora E Sarvetnick; Bennett O V Shum; Jenna M Sullivan; Ana C Anderson; Denise Chung; Anneli Jäger; David H Lee; Vijay K Kuchroo
Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice.
The Journal of clinical investigation 2011;121(11):4303-10.
2011: Judong Lee; Jamie A Moroco; Jiayao Phuah; Thomas E Smithgall; Ee Wern Su; Chen Zhu; Sarah Hainline; Vijay K Kuchroo; Lawrence P Kane
Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.
Molecular and cellular biology 2011;31(19):3963-74.
2011: Amit Awasthi; Vijay K Kuchroo
Value added: neural progenitor cells suppress inflammation and autoimmunity.
Immunity 2011;35(2):156-7.
2011: Paresh Thakker; Stanley Wolf; Andrew Wood; James D Clark; Mary Collins; Samuel J Goldman; Vijay K Kuchroo; Michael W Leach; Katherine L Lee; Suzana Marusic; John C McKew; Nancy L Stedman; Mina Hassan-Zahraee
Cytosolic phospholipase A2α blockade abrogates disease during the tissue-damage effector phase of experimental autoimmune encephalomyelitis by its action on APCs.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(4):1986-97.
2011: Kaori Sakuishi; Ana C Anderson; Samuel M Behar; Pushpa Jayaraman; Vijay K Kuchroo
Emerging Tim-3 functions in antimicrobial and tumor immunity.
Trends in immunology 2011;32(8):345-9.
2011: Enric Esplugues; Jeffrey A Bluestone; Nicola Gagliani; Ann M Haberman; Anja E Hauser; Kevan C Herold; Samuel Huber; Yoichiro Iwakura; Jay K Kolls; Vijay K Kuchroo; William O'Connor; Anthony Rongvaux; Terrence Town; Nico van Rooijen; Yisong Y Wan; Richard A Flavell
Control of TH17 cells occurs in the small intestine.
Nature 2011;475(7357):514-8.
2011: Caroline Pot; Lionel Apetoh; Vijay K Kuchroo
Type 1 regulatory T cells (Tr1) in autoimmunity.
Seminars in immunology 2011;23(3):202-8.
2011: Sheng Xiao; Bing Zhu; Hulin Jin; Chen Zhu; Dale T Umetsu; Rosemarie H Dekruyff; Vijay K Kuchroo
Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells.
European journal of immunology 2011;41(6):1539-49.
2011: Qing Zhou; Meghan E Munger; Rachelle G Veenstra; Brenda J Weigel; Mitsuomi Hirashima; David H Munn; William Murphy; Miyuki Azuma; Ana C Anderson; Vijay K Kuchroo; Bruce R Blazar
Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.
Blood 2011;117(17):4501-10.
2011: Marie Wahren-Herlenius; Vijay K Kuchroo
Gene-environment interaction in induction of autoimmunity.
Seminars in immunology 2011;23(2):65-6.
2011: Nicole Joller; Jason P Hafler; Boel Brynedal; Nasim Kassam; Silvia Spoerl; Steven D Levin; Arlene H Sharpe; Vijay K Kuchroo
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(3):1338-42.
2011: Vanja Lazarevic; Xi Chen; Jae-Hyuck Shim; Eun-Sook Hwang; Eunjung Jang; Alexandra N Bolm; Mohamed Oukka; Vijay K Kuchroo; Laurie H Glimcher
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt.
Nature immunology 2011;12(1):96-104.
2011: Chen Zhu; Ana C Anderson; Vijay K Kuchroo
TIM-3 and its regulatory role in immune responses.
Current topics in microbiology and immunology 2011;350():1-15.
2010: Pushpa Jayaraman; Isabel Sada-Ovalle; Sarah Beladi; Ana C Anderson; Valerie Dardalhon; Chie Hotta; Vijay K Kuchroo; Samuel M Behar
Tim3 binding to galectin-9 stimulates antimicrobial immunity.
The Journal of experimental medicine 2010;207(11):2343-54.
2010: Kaori Sakuishi; Lionel Apetoh; Jenna M Sullivan; Bruce R Blazar; Vijay K Kuchroo; Ana C Anderson
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity.
The Journal of experimental medicine 2010;207(10):2187-94.
2010: Franziska Petermann; Veit Rothhammer; Malte C Claussen; Jan D Haas; Lorena Riol Blanco; Sylvia Heink; Immo Prinz; Bernhard Hemmer; Vijay K Kuchroo; Mohamed Oukka; Thomas Korn
γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism.
Immunity 2010;33(3):351-63.
2010: Linn S Strandberg; Aurelie Ambrosi; Maja Jagodic; Vijole Dzikaite; Peter Janson; Mohsen Khademi; Stina Salomonsson; Lars Ottosson; Robert Klauninger; Ulrika Adén; Sven-Erik Sonesson; Maria Sunnerhagen; Katrien L de Graaf; Vijay K Kuchroo; Adnane Achour; Ola Winqvist; Tomas Olsson; Marie Wahren-Herlenius
Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(6):3574-82.
2010: A Jäger; Vijay K Kuchroo
Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation.
Scandinavian journal of immunology 2010;72(3):173-84.
2010: Lionel Apetoh; Francisco J Quintana; Caroline Pot; Nicole Joller; Sheng Xiao; Deepak Kumar; Evan J Burns; David H Sherr; Howard L Weiner; Vijay K Kuchroo
The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.
Nature immunology 2010;11(9):854-61.
2010: Hyun-Tak Jin; Ana C Anderson; Wendy G Tan; Erin E West; Sang-Jun Ha; Koichi Araki; Gordon J Freeman; Vijay K Kuchroo; Rafi Ahmed
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(33):14733-8.
2010: Meike Mitsdoerffer; Youjin Lee; Anneli Jäger; Hye-Jung Kim; Thomas Korn; Jay K Kolls; Harvey Cantor; Estelle Bettelli; Vijay K Kuchroo
Proinflammatory T helper type 17 cells are effective B-cell helpers.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14292-7.
2010: Valérie Dardalhon; Ana C Anderson; Jozsef Karman; Lionel Apetoh; Rucha Chandwaskar; David H Lee; Melanie Cornejo; Nozomu Nishi; Akira Yamauchi; Francisco J Quintana; Raymond A Sobel; Mitsuomi Hirashima; Vijay K Kuchroo
Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(3):1383-92.
2010: Gaëlle Beriou; Elizabeth M Bradshaw; Ester Lozano; Cristina M Costantino; William D Hastings; Tihamer Orban; Wassim Elyaman; Samia J Khoury; Vijay K Kuchroo; Clare Baecher-Allan; David A Hafler
TGF-beta induces IL-9 production from human Th17 cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):46-54.
2010: Caroline Pot; Lionel Apetoh; Amit Awasthi; Vijay K Kuchroo
Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010;30(6):381-8.
2010: Roselynn Rodriguez-Manzanet; Miguel A Sanjuan; Henry Y Wu; Francisco J Quintana; Sheng Xiao; Ana C Anderson; Howard L Weiner; Douglas R Green; Vijay K Kuchroo
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(19):8706-11.
2010: Ana C Anderson; Graham M Lord; Valerie Dardalhon; David H Lee; Catherine A Sabatos-Peyton; Laurie H Glimcher; Vijay K Kuchroo
T-bet, a Th1 transcription factor regulates the expression of Tim-3.
European journal of immunology 2010;40(3):859-66.
2010: Lorena Riol-Blanco; Vanja Lazarevic; Amit Awasthi; Meike Mitsdoerffer; Brian S Wilson; Andy Croxford; Ari Waisman; Vijay K Kuchroo; Laurie H Glimcher; Mohamed Oukka
IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):1710-20.
2010: Thomas Korn; Meike Mitsdoerffer; Vijay K Kuchroo
Immunological basis for the development of tissue inflammation and organ-specific autoimmunity in animal models of multiple sclerosis.
Results and problems in cell differentiation 2010;51():43-74.
2009: Loise M Francisco; Victor H Salinas; Keturah E Brown; Vijay K Vanguri; Gordon J Freeman; Vijay K Kuchroo; Arlene H Sharpe
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells.
The Journal of experimental medicine 2009;206(13):3015-29.
2009: Anneli Jäger; Valérie Dardalhon; Raymond A Sobel; Estelle Bettelli; Vijay K Kuchroo
Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):7169-77.
2009: Manabu Araki; Denise Chung; Sue Liu; Daniel B Rainbow; Giselle Chamberlain; Valerie Garner; Kara M D Hunter; Lalitha Vijayakrishnan; Laurence B Peterson; Mohamed Oukka; Arlene H Sharpe; Raymond Sobel; Vijay K Kuchroo; Linda S Wicker
Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5146-57.
2009: William D Hastings; David E Anderson; Nasim Kassam; Ken Koguchi; Edward Greenfield; Sally C Kent; Xin Xiao Zheng; Terry B Strom; David A Hafler; Vijay K Kuchroo
TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines.
European journal of immunology 2009;39(9):2492-501.
2009: Pierre Miossec; Thomas Korn; Vijay K Kuchroo
Interleukin-17 and type 17 helper T cells.
The New England journal of medicine 2009;361(9):888-98.
2009: Amit Awasthi; Vijay K Kuchroo
Immunology. The yin and yang of follicular helper T cells.
Science (New York, N.Y.) 2009;325(5943):953-5.
2009: Wassim Elyaman; Elizabeth M Bradshaw; Catherine Uyttenhove; Valérie Dardalhon; Amit Awasthi; Jaime Imitola; Estelle Bettelli; Mohamed Oukka; Jacques Van Snick; Jean-Christophe Renauld; Vijay K Kuchroo; Samia J Khoury
IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12885-90.
2009: Alexander Espinosa; Valerie Dardalhon; Susanna Brauner; Aurelie Ambrosi; Rowan Higgs; Fransisco J Quintana; Maria Sjöstrand; Maija-Leena Eloranta; Joan Ní Gabhann; Ola Winqvist; Birgitta Sundelin; Caroline Jefferies; Björn Rozell; Vijay K Kuchroo; Marie Wahren-Herlenius
Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway.
The Journal of experimental medicine 2009;206(8):1661-71.
2009: Vilija Oke; Ismini Vassilaki; Alexander Espinosa; Linn Strandberg; Vijay K Kuchroo; Filippa Nyberg; Marie Wahren-Herlenius
High Ro52 expression in spontaneous and UV-induced cutaneous inflammation.
The Journal of investigative dermatology 2009;129(8):2000-10.
2009: Caroline Pot; Hulin Jin; Amit Awasthi; Sue Min Liu; Chen-Yen Lai; Rajat Madan; Arlene H Sharpe; Christopher L Karp; Shi-Chuen Miaw; I-Cheng Ho; Vijay K Kuchroo
Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):797-801.
2009: Amit Awasthi; Vijay K Kuchroo
IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation.
Nature immunology 2009;10(6):568-70.
2009: Amit Awasthi; Lorena Riol-Blanco; Anneli Jäger; Thomas Korn; Caroline Pot; George Galileos; Estelle Bettelli; Vijay K Kuchroo; Mohamed Oukka
Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):5904-8.
2009: Roselynn Rodriguez-Manzanet; Rosemarie DeKruyff; Vijay K Kuchroo; Dale T Umetsu
The costimulatory role of TIM molecules.
Immunological reviews 2009;229(1):259-70.
2009: Amit Awasthi; Vijay K Kuchroo
Th17 cells: from precursors to players in inflammation and infection.
International immunology 2009;21(5):489-98.
2009: Gaëlle Beriou; Cristina M Costantino; Charles W Ashley; Li Yang; Vijay K Kuchroo; Clare Baecher-Allan; David A Hafler
IL-17-producing human peripheral regulatory T cells retain suppressive function.
Blood 2009;113(18):4240-9.
2009: Stefan H E Kaufmann; Vijay K Kuchroo
Th17 cells.
Microbes and infection / Institut Pasteur 2009;11(5):579-83.
2009: Christophe Mariat; Nicolas Degauque; Savithri Balasubramanian; James Kenny; Rosemarie H Dekruyff; Dale T Umetsu; Vijay K Kuchroo; Xin Xiao Zheng; Terry B Strom
Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1379-85.
2009: Aurelie Bauquet; Hulin Jin; Alison M Paterson; Meike Mitsdoerffer; I-Cheng Ho; Arlene H Sharpe; Vijay K Kuchroo
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells.
Nature immunology 2009;10(2):167-75.
2009: Thomas Korn; Estelle Bettelli; Mohamed Oukka; Vijay K Kuchroo
IL-17 and Th17 Cells.
Annual review of immunology 2009;27():485-517.
2008: Keiko Nagahara; Tomohiro Arikawa; Souichi Oomizu; Keiichi Kontani; Atsuya Nobumoto; Hiroaki Tateno; Kota Watanabe; Toshiro Niki; Shigeki Katoh; Minoru Miyake; Syun-Ichiro Nagahata; Jun Hirabayashi; Vijay K Kuchroo; Akira Yamauchi; Mitsuomi Hirashima
Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7660-9.
2008: Ana C Anderson; Rucha Chandwaskar; David H Lee; Vijay K Kuchroo
Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7449-52.
2008: Valérie Dardalhon; Amit Awasthi; Hyoung Kwon; George Galileos; Wenda Gao; Raymond A Sobel; Meike Mitsdoerffer; Terry B Strom; Wassim Elyaman; I-Cheng Ho; Samia Khoury; Mohamed Oukka; Vijay K Kuchroo
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.
Nature immunology 2008;9(12):1347-55.
2008: Thomas Korn; Meike Mitsdoerffer; Andrew L Croxford; Amit Awasthi; Valérie A Dardalhon; George Galileos; Patrick Vollmar; Gretta L Stritesky; Mark H Kaplan; Ari Waisman; Vijay K Kuchroo; Mohamed Oukka
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18460-5.
2008: David A Hafler; Vijay K Kuchroo
TIMs: central regulators of immune responses.
The Journal of experimental medicine 2008;205(12):2699-701.
2008: Amit Awasthi; Gopal Murugaiyan; Vijay K Kuchroo
Interplay between effector Th17 and regulatory T cells.
Journal of clinical immunology 2008;28(6):660-70.
2008: Valérie Dardalhon; Thomas Korn; Vijay K Kuchroo; Ana C Anderson
Role of Th1 and Th17 cells in organ-specific autoimmunity.
Journal of autoimmunity 2008;31(3):252-6.
2008: Sheng Xiao; Hulin Jin; Thomas Korn; Sue M Liu; Mohamed Oukka; Bing Lim; Vijay K Kuchroo
Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(4):2277-84.
2008: Yasmina Laouar; Terrence Town; David Jeng; Elise Tran; Yisong Y Wan; Vijay K Kuchroo; Richard A Flavell
TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10865-70.
2008: Vijay K Kuchroo; Valerie Dardalhon; Sheng Xiao; Ana C Anderson
New roles for TIM family members in immune regulation.
Nature reviews. Immunology 2008;8(8):577-80.
2008: Wassim Elyaman; Pia Kivisäkk; Jayagopala Reddy; Tanuja Chitnis; Khadir Raddassi; Jaime Imitola; Elizabeth Bradshaw; Vijay K Kuchroo; Hideo Yagita; Mohamed H Sayegh; Samia J Khoury
Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis.
The American journal of pathology 2008;173(2):411-22.
2008: Li Yang; David E Anderson; Clare Baecher-Allan; William D Hastings; Estelle Bettelli; Mohamed Oukka; Vijay K Kuchroo; David A Hafler
IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.
Nature 2008;454(7202):350-2.
2008: Estelle Bettelli; Thomas Korn; Mohamed Oukka; Vijay K Kuchroo
Induction and effector functions of T(H)17 cells.
Nature 2008;453(7198):1051-7.
2008: Mei-Ling Chen; Bo-Shiun Yan; Yoshio Bando; Vijay K Kuchroo; Howard L Weiner
Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7327-37.
2008: Arthur O Tzianabos; Matthew A Holsti; Xin Xiao Zheng; Arthur F Stucchi; Vijay K Kuchroo; Terry B Strom; Laurie H Glimcher; William W Cruikshank
Functional Th1 cells are required for surgical adhesion formation in a murine model.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6970-6.
2008: Linn Strandberg; Aurelie Ambrosi; Alexander Espinosa; Lars Ottosson; Maija-Leena Eloranta; Wei Zhou; Ase Elfving; Edward Greenfield; Vijay K Kuchroo; Marie Wahren-Herlenius
Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies.
Journal of clinical immunology 2008;28(3):220-31.
2008: Roselynn Rodriguez-Manzanet; Jennifer Hartt Meyers; Savithri Balasubramanian; Jacqueline Slavik; Nasim Kassam; Valerie Dardalhon; Edward Greenfield; Ana C Anderson; Raymond A Sobel; David A Hafler; Terry B Strom; Vijay K Kuchroo
TIM-4 expressed on APCs induces T cell expansion and survival.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4706-13.
2008: Masako Seki; Souichi Oomizu; Ken-Mei Sakata; Atsuko Sakata; Tomohiro Arikawa; Kota Watanabe; Kanako Ito; Keisuke Takeshita; Toshiro Niki; Naoki Saita; Nozomu Nishi; Akira Yamauchi; Shigeki Katoh; Akihiro Matsukawa; Vijay K Kuchroo; Mitsuomi Hirashima
Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis.
Clinical immunology (Orlando, Fla.) 2008;127(1):78-88.
2008: Nicolas Degauque; Christophe Mariat; James Kenny; Dong Zhang; Wenda Gao; Minh Diem Vu; Sophoclis Alexopoulos; Mohammed Oukka; Dale T Umetsu; Rosemarie H Dekruyff; Vijay K Kuchroo; Xin Xiao Zheng; Terry B Strom
Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.
The Journal of clinical investigation 2008;118(2):735-41.
2007: Masako Seki; Ken-mei Sakata; Souichi Oomizu; Tomohiro Arikawa; Atsuko Sakata; Masaki Ueno; Atsuya Nobumoto; Toshiro Niki; Naoki Saita; Kanako Ito; Shu-Yan Dai; Shigeki Katoh; Nozomu Nishi; Michishi Tsukano; Kouichiro Ishikawa; Akira Yamauchi; Vijay K Kuchroo; Mitsuomi Hirashima
Beneficial effect of galectin 9 on rheumatoid arthritis by induction of apoptosis of synovial fibroblasts.
Arthritis and rheumatism 2007;56(12):3968-76.
2007: Amit Awasthi; Yijun Carrier; Jean P S Peron; Estelle Bettelli; Masahito Kamanaka; Richard A Flavell; Vijay K Kuchroo; Mohamed Oukka; Howard L Weiner
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.
Nature immunology 2007;8(12):1380-9.
2007: Estelle Bettelli; Thomas Korn; Vijay K Kuchroo
Th17: the third member of the effector T cell trilogy.
Current opinion in immunology 2007;19(6):652-7.
2007: Ana C Anderson; David E Anderson; Lisa Bregoli; William D Hastings; Nasim Kassam; Charles Lei; Rucha Chandwaskar; Jozsef Karman; Ee W Su; Mitsuomi Hirashima; Jeffrey N Bruce; Lawrence P Kane; Vijay K Kuchroo; David A Hafler
Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.
Science (New York, N.Y.) 2007;318(5853):1141-3.
2007: Bing Zhu; Yoshio Bando; Sheng Xiao; Kaiyong Yang; Ana C Anderson; Vijay K Kuchroo; Samia J Khoury
CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5228-37.
2007: Zsolt Illés; Hanspeter Waldner; Jayagopala Reddy; Ana C Anderson; Raymond A Sobel; Vijay K Kuchroo
Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background.
International immunology 2007;19(10):1235-48.
2007: Thomas Korn; Estelle Bettelli; Wenda Gao; Amit Awasthi; Anneli Jäger; Terry B Strom; Mohamed Oukka; Vijay K Kuchroo
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.
Nature 2007;448(7152):484-7.
2007: Nicolas Degauque; Christophe Mariat; James Kenny; Alberto Sanchez-Fueyo; Sophoclis P Alexopoulos; Vijay K Kuchroo; Xin Xiao Zheng; Terry B Strom
Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins.
Transplantation 2007;84(1 Suppl):S12-6.
2007: Sheng Xiao; Nader Najafian; Jayagopala Reddy; Monica J Albin; Chen Zhu; Eric Jensen; Jaime Imitola; Thomas Korn; Ana C Anderson; Zheng Zhang; Cristina Gutierrez; Thomas Moll; Raymond A Sobel; Dale T Umetsu; Hideo Yagita; Hisaya Akiba; Terry Strom; Mohamed H Sayegh; Rosemarie H Dekruyff; Samia J Khoury; Vijay K Kuchroo
Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.
The Journal of experimental medicine 2007;204(7):1691-702.
2007: Bernhard Greve; Robert Weissert; Nada Hamdi; Estelle Bettelli; Raymond A Sobel; Anthony J Coyle; Vijay K Kuchroo; Klaus Rajewsky; Marc Schmidt-Supprian
I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):179-85.
2007: Silvia Deaglio; Karen M Dwyer; Keiichii Enjyoji; Anna Erat; David Friedman; Wenda Gao; Vijay K Kuchroo; Joel Linden; Mohamed Oukka; Terry B Strom; Anny Usheva; Jiang-Fan Chen; Simon C Robson
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.
The Journal of experimental medicine 2007;204(6):1257-65.
2007: Thomas Korn; Jayagopala Reddy; Wenda Gao; Estelle Bettelli; Amit Awasthi; Troels R Petersen; B Thomas Bäckström; Raymond A Sobel; Kai W Wucherpfennig; Terry B Strom; Mohamed Oukka; Vijay K Kuchroo
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.
Nature medicine 2007;13(4):423-31.
2007: Estelle Bettelli; Mohamed Oukka; Vijay K Kuchroo
T(H)-17 cells in the circle of immunity and autoimmunity.
Nature immunology 2007;8(4):345-50.
2007: Ana C Anderson; Sheng Xiao; Vijay K Kuchroo
Tim protein structures reveal a unique face for ligand binding.
Immunity 2007;26(3):273-5.
2007: Kevin C O'Connor; Katherine McLaughlin; Philip De Jager; Tanuja Chitnis; Estelle Bettelli; Chenqi Xu; William H Robinson; Sunil V Cherry; Amit Bar-Or; Brenda L Banwell; Hikoaki Fukaura; Toshiyuki Fukazawa; Silvia Tenembaum; Susan J Wong; Norma P Tavakoli; Zhannat Idrissova; Vissia Viglietta; Kevin Rostasy; Daniela Pohl; Russell C Dale; Mark Freedman; Lawrence Steinman; Guy J Buckle; Vijay K Kuchroo; David A Hafler; Kai W Wucherpfennig
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein.
Nature medicine 2007;13(2):211-7.
2007: Yijun Carrier; Jing Yuan; Vijay K Kuchroo; Howard L Weiner
Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):179-85.
2007: Yijun Carrier; Jing Yuan; Vijay K Kuchroo; Howard L Weiner
Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):172-8.
2006: Estelle Bettelli; Dominique Baeten; Anneli Jäger; Raymond A Sobel; Vijay K Kuchroo
Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice.
The Journal of clinical investigation 2006;116(9):2393-402.
2006: Laura Haynes; Suzanne Pfeffer; Jeremy M Boss; Paula B Kavathas; Vijay K Kuchroo
Lab management: insights for the new investigator.
Nature immunology 2006;7(9):895-7.
2006: Ken Koguchi; David E Anderson; Li Yang; Kevin C O'Connor; Vijay K Kuchroo; David A Hafler
Dysregulated T cell expression of TIM3 in multiple sclerosis.
The Journal of experimental medicine 2006;203(6):1413-8.
2006: Alexander Espinosa; Wei Zhou; Monica Ek; Malin Hedlund; Susanna Brauner; Karin Popovic; Linn Horvath; Therese Wallerskog; Mohamed Oukka; Fredrik Nyberg; Vijay K Kuchroo; Marie Wahren-Herlenius
The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6277-85.
2006: Estelle Bettelli; Yijun Carrier; Wenda Gao; Thomas Korn; Terry B Strom; Mohamed Oukka; Howard L Weiner; Vijay K Kuchroo
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Nature 2006;441(7090):235-8.
2006: Hanspeter Waldner; Raymond A Sobel; Nichole Price; Vijay K Kuchroo
The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5455-62.
2006: Xingmin Zhang; Jayagopala Reddy; Hirofumi Ochi; Dan Frenkel; Vijay K Kuchroo; Howard L Weiner
Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells.
International immunology 2006;18(4):495-503.
2006: Edward Greenfield; Jayagopala Reddy; Andrew Lees; Charissa A Dyer; Omanand Koul; Khuong Nguyen; Shannon Bell; Nasim Kassam; Julian Hinojoza; Mary Jane Eaton; Marjorie B Lees; Vijay K Kuchroo; Raymond A Sobel
Monoclonal antibodies to distinct regions of human myelin proteolipid protein simultaneously recognize central nervous system myelin and neurons of many vertebrate species.
Journal of neuroscience research 2006;83(3):415-31.
2006: Vijay K Kuchroo; Jennifer Hartt Meyers; Dale T Umetsu; Rosemarie H Dekruyff
TIM family of genes in immunity and tolerance.
Advances in immunology 2006;91():227-49.
2005: Katsuichi Miyamoto; Cherry I Kingsley; Xingmin Zhang; Claudia Jabs; Leonid Izikson; Raymond A Sobel; Howard L Weiner; Vijay K Kuchroo; Arlene H Sharpe
The ICOS molecule plays a crucial role in the development of mucosal tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7341-7.
2005: Chen Zhu; Ana C Anderson; Anna Schubart; Huabao Xiong; Jaime Imitola; Samia J Khoury; Xin Xiao Zheng; Terry B Strom; Vijay K Kuchroo
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.
Nature immunology 2005;6(12):1245-52.
2005: Zsolt Illes; Joel N H Stern; Derin B Keskin; Jayagopala Reddy; Celia F Brosnan; Hanspeter Waldner; Laura Santambrogio; Vijay K Kuchroo; Jack L Strominger
Copolymer effects on microglia and T cells in the central nervous system of humanized mice.
European journal of immunology 2005;35(12):3683-93.
2005: Jayagopala Reddy; Hanspeter Waldner; Xingmin Zhang; Zsolt Illes; Kai W Wucherpfennig; Raymond A Sobel; Vijay K Kuchroo
Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5591-5.
2005: Janosch Hennig; Lars Ottosson; Cecilia Andrésen; Linn Horvath; Vijay K Kuchroo; Klas Broo; Marie Wahren-Herlenius; Maria Sunnerhagen
Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52.
The Journal of biological chemistry 2005;280(39):33250-61.
2005: Sumone Chakravarti; Catherine A Sabatos; Sheng Xiao; Zsolt Illes; Eugene K Cha; Raymond A Sobel; Xin Xiao Zheng; Terry B Strom; Vijay K Kuchroo
Tim-2 regulates T helper type 2 responses and autoimmunity.
The Journal of experimental medicine 2005;202(3):437-44.
2005: Valerie Dardalhon; Anna S Schubart; Jayagopala Reddy; Jennifer Hartt Meyers; Laurent Monney; Catherine A Sabatos; Rakesh Ahuja; Khuong Nguyen; Gordon J Freeman; Edward Greenfield; Raymond A Sobel; Vijay K Kuchroo
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1558-65.
2005: Zsolt Illés; Hanspeter Waldner; Jayagopala Reddy; Estelle Bettelli; Lindsay B Nicholson; Vijay K Kuchroo
T cell tolerance induced by cross-reactive TCR ligands can be broken by superagonist resulting in anti-inflammatory T cell cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1491-7.
2005: Jennifer Hartt Meyers; Catherine A Sabatos; Sumone Chakravarti; Vijay K Kuchroo
The TIM gene family regulates autoimmune and allergic diseases.
Trends in molecular medicine 2005;11(8):362-9.
2005: Ping Yu; Randal K Gregg; J Jeremiah Bell; Jason S Ellis; Rohit Divekar; Hyun-Hee Lee; Renu Jain; Hanspeter Waldner; John C Hardaway; Mary Collins; Vijay K Kuchroo; Habib Zaghouani
Specific T regulatory cells display broad suppressive functions against experimental allergic encephalomyelitis upon activation with cognate antigen.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):6772-80.
2005: Jennifer Hartt Meyers; Sumone Chakravarti; David Schlesinger; Zsolt Illes; Hanspeter Waldner; Sarah E Umetsu; James Kenny; Xin Xiao Zheng; Dale T Umetsu; Rosemarie H Dekruyff; Terry B Strom; Vijay K Kuchroo
TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation.
Nature immunology 2005;6(5):455-64.
2005: Stephan Ellmerich; Marcin P Mycko; Katalin Takacs; Hanspeter Waldner; Faisal Wahid; Rosemary J Boyton; Rosalind H M King; Paul A Smith; Sandra Amor; Amy H Herlihy; Rachel E Hewitt; Mark Jutton; David A Price; David A Hafler; Vijay K Kuchroo; Daniel M Altmann
High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):1938-46.
2005: Lars Ottosson; Stina Salomonsson; Janosch Hennig; Sven-Erik Sonesson; T Dörner; Jos M H Raats; Vijay K Kuchroo; Maria Sunnerhagen; Marie Wahren-Herlenius
Structurally derived mutations define congenital heart block-related epitopes within the 200-239 amino acid stretch of the Ro52 protein.
Scandinavian journal of immunology 2005;61(2):109-18.
2005: Joel N H Stern; Zsolt Illés; Jayagopala Reddy; Derin B Keskin; Masha Fridkis-Hareli; Vijay K Kuchroo; Jack L Strominger
Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1620-5.
2005: Estelle Bettelli; Vijay K Kuchroo
IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together.
The Journal of experimental medicine 2005;201(2):169-71.
2005: Stina Salomonsson; Sven-Erik Sonesson; Lars Ottosson; Saad Muhallab; Tomas Olsson; Maria Sunnerhagen; Vijay K Kuchroo; Peter Thorén; Eric Herlenius; Marie Wahren-Herlenius
Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.
The Journal of experimental medicine 2005;201(1):11-7.
2005: Lalitha Vijayakrishnan; Jacqueline Slavik; Zsolt Illés; Dan Rainbow; Laurence B Peterson; Arlene S Sharpe; Linda S Wicker; Vijay K Kuchroo
An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells.
Novartis Foundation symposium 2005;267():200-12; discussion 212-8.
2004: Jayagopala Reddy; Zsolt Illes; Xingmin Zhang; Jeffrey Encinas; Jason Pyrdol; Lindsay Nicholson; Raymond A Sobel; Kai W Wucherpfennig; Vijay K Kuchroo
Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15434-9.
2004: Carlos Eduardo Tadokoro; Adriana L Vallochi; Lília S Rios; Gislaine Martins; David Schlesinger; Tainá Mosca; Vijay K Kuchroo; Luiz Vicente Rizzo; Ises A Abrahamsohn
Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi.
Journal of autoimmunity 2004;23(2):103-15.
2004: Joel N H Stern; Zsolt Illés; Jayagopala Reddy; Derin B Keskin; Eric Sheu; Masha Fridkis-Hareli; Hiroyuki Nishimura; Celia F Brosnan; Laura Santambrogio; Vijay K Kuchroo; Jack L Strominger
Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11743-8.
2004: Zsolt Illés; Joel N H Stern; Jayagopala Reddy; Hanspeter Waldner; Marcin P Mycko; Celia F Brosnan; Stephan Ellmerich; Daniel M Altmann; Laura Santambrogio; Jack L Strominger; Vijay K Kuchroo
Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11749-54.
2004: Marcin P Mycko; Hanspeter Waldner; David E Anderson; Katarzyna D Bourcier; Kai W Wucherpfennig; Vijay K Kuchroo; David A Hafler
Cross-reactive TCR responses to self antigens presented by different MHC class II molecules.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1689-98.
2004: Yvette E Latchman; Spencer C Liang; Yin Wu; Tatyana Chernova; Raymond A Sobel; Martina Klemm; Vijay K Kuchroo; Gordon J Freeman; Arlene H Sharpe
PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10691-6.
2004: Ana C Anderson; Jayagopala Reddy; Remedios F Nazareno; Raymond A Sobel; Lindsay B Nicholson; Vijay K Kuchroo
IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):828-34.
2004: Estelle Bettelli; Brandon Sullivan; Susanne J Szabo; Raymond A Sobel; Laurie H Glimcher; Vijay K Kuchroo
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 2004;200(1):79-87.
2004: Stephan Ellmerich; Katalin Takacs; Marcin P Mycko; Hanspeter Waldner; Faisal Wahid; Rosemary J Boyton; Paul A Smith; Sandra Amor; David Baker; David A Hafler; Vijay K Kuchroo; Daniel M Altmann
Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis.
European journal of immunology 2004;34(7):1839-48.
2004: Bernhard Greve; Jayagopala Reddy; Hanspeter Waldner; Raymond A Sobel; Vijay K Kuchroo
Dissimilar background genes control susceptibility to autoimmune disease in the context of different MHC haplotypes: NOD.H-2(s) congenic mice are relatively resistant to both experimental autoimmune encephalomyelitis and type I diabetes.
European journal of immunology 2004;34(7):1828-38.
2004: Bernhard Greve; Lalitha Vijayakrishnan; Aarup Kubal; Raymond A Sobel; Laurence B Peterson; Linda S Wicker; Vijay K Kuchroo
The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):157-63.
2004: Troels R Petersen; Sven Gülland; Estelle Bettelli; Vijay K Kuchroo; Ed Palmer; B Thomas Bäckström
A chimeric T cell receptor with super-signaling properties.
International immunology 2004;16(7):889-94.
2004: Daniel Hawiger; Revati F Masilamani; Estelle Bettelli; Vijay K Kuchroo; Michel C Nussenzweig
Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo.
Immunity 2004;20(6):695-705.
2004: Mohsen Khademi; Zsolt Illés; Alexander W Gielen; Monica Marta; Naruhiko Takazawa; Claire Baecher-Allan; Lou Brundin; Jan Hannerz; Claes Martin; Robert A Harris; David A Hafler; Vijay K Kuchroo; Tomas Olsson; Fredrik Piehl; Erik Wallström
T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):7169-76.
2004: Lalitha Vijayakrishnan; Jacqueline Slavik; Zsolt Illés; Rebecca J Greenwald; Dan Rainbow; Bernhard Greve; Laurence B Peterson; David A Hafler; Gordon J Freeman; Arlene H Sharpe; Linda S Wicker; Vijay K Kuchroo
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.
Immunity 2004;20(5):563-75.
2004: Hanspeter Waldner; Mary Collins; Vijay K Kuchroo
Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease.
The Journal of clinical investigation 2004;113(7):990-7.
2004: Xingmin Zhang; Djordje N Koldzic; Leonid Izikson; Jayagopala Reddy; Remedios F Nazareno; Shimon Sakaguchi; Vijay K Kuchroo; Howard L Weiner
IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells.
International immunology 2004;16(2):249-56.
2004: Troels R Petersen; Estelle Bettelli; John Sidney; Alessandro Sette; Vijay K Kuchroo; B Thomas Bäckström
Characterization of MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38-51 peptide.
European journal of immunology 2004;34(1):165-73.
2003: Ana C Anderson; Vijay K Kuchroo
Expression of self-antigen in the thymus: a little goes a long way.
The Journal of experimental medicine 2003;198(11):1627-9.
2003: Catherine A Sabatos; Sumone Chakravarti; Eugene Cha; Anna Schubart; Alberto Sánchez-Fueyo; Xin Xiao Zheng; Anthony J Coyle; Terry B Strom; Gordon J Freeman; Vijay K Kuchroo
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance.
Nature immunology 2003;4(11):1102-10.
2003: Alberto Sánchez-Fueyo; Jane Tian; Dominic Picarella; Christoph Domenig; Xin Xiao Zheng; Catherine A Sabatos; Natasha Manlongat; Orissa Bender; Thomas Kamradt; Vijay K Kuchroo; José-Carlos Gutiérrez-Ramos; Anthony J Coyle; Terry B Strom
Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.
Nature immunology 2003;4(11):1093-101.
2003: William H Robinson; Paulo Fontoura; Byung J Lee; Henry Neuman de Vegvar; Jennifer Tom; Rosetta Pedotti; Carla DiGennaro; Dennis J Mitchell; Derek Fong; Peggy P Ho; Pedro J Ruiz; Emanual Maverakis; David B Stevens; Claude C A Bernard; Roland Martin; Vijay K Kuchroo; Johannes M van Noort; Claude P Genain; Sandra Amor; Tomas Olsson; Paul J Utz; Hideki Garren; Lawrence Steinman
Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis.
Nature biotechnology 2003;21(9):1033-9.
2003: Tammy T Chang; Raymond A Sobel; Tao Wei; Richard M Ransohoff; Vijay K Kuchroo; Arlene H Sharpe
Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice.
European journal of immunology 2003;33(7):2022-2032.
2003: Estelle Bettelli; Lindsay B Nicholson; Vijay K Kuchroo
IL-10, a key effector regulatory cytokine in experimental autoimmune encephalomyelitis.
Journal of autoimmunity 2003;20(4):265-7.
2003: Vijay K Kuchroo; Dale T Umetsu; Rosemarie H Dekruyff; Gordon J Freeman
The TIM gene family: emerging roles in immunity and disease.
Nature reviews. Immunology 2003;3(6):454-62.
2003: Estelle Bettelli; Maria Pagany; Howard L Weiner; Christopher Linington; Raymond A Sobel; Vijay K Kuchroo
Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis.
The Journal of experimental medicine 2003;197(9):1073-81.
2003: Vijay K Kuchroo; Lindsay B Nicholson
Immunology: Fast and feel good?
Nature 2003;422(6927):27-8.
2003: Jayagopala Reddy; Estelle Bettelli; Lindsay Nicholson; Hanspeter Waldner; Mei-Huei Jang; Kai W Wucherpfennig; Vijay K Kuchroo
Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):870-7.
2002: Marie Wahren-Herlenius; Vijay K Kuchroo
Killers come to the rescue.
Nature biotechnology 2002;20(12):1205-6.
2002: Jennifer Hartt Meyers; Akemi Ryu; Laurent Monney; Khuong Nguyen; Edward Greenfield; Gordon J Freeman; Vijay K Kuchroo
Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5382-6.
2002: Markus Munder; Estelle Bettelli; Laurent Monney; Jacqueline Slavik; Lindsay B Nicholson; Vijay K Kuchroo
Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand.
The Journal of experimental medicine 2002;196(9):1151-62.
2002: Duncan Howie; Susumo Okamoto; svend rietdijk; Kareem Clarke; Ninghai Wang; Charles Gullo; Joost P Bruggeman; Stephen Manning; Anthony J Coyle; Edward Greenfield; Vijay K Kuchroo; Cox Terhorst
The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production.
Blood 2002;100(8):2899-907.
2002: Claudia Jabs; Bernhard Greve; Tammy T Chang; Raymond A Sobel; Arlene H Sharpe; Vijay K Kuchroo
Genetic background determines the requirement for B7 costimulation in induction of autoimmunity.
European journal of immunology 2002;32(9):2687-97.
2002: Gordon J Freeman; Arlene H Sharpe; Vijay K Kuchroo
Protect the killer: CTLs need defenses against the tumor.
Nature medicine 2002;8(8):787-9.
2002: Miren L Baroja; Lalitha Vijayakrishnan; Estelle Bettelli; Peter J Darlington; Thu A Chau; Vincent Ling; Mary Collins; Beatriz M Carreno; Joaquín Madrenas; Vijay K Kuchroo
Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):5070-8.
2002: Laurent Monney; Catherine A Sabatos; Jason L Gaglia; Akemi Ryu; Hanspeter Waldner; Tatyana Chernova; Stephen Manning; Edward Greenfield; Anthony J Coyle; Raymond A Sobel; Gordon J Freeman; Vijay K Kuchroo
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.
Nature 2002;415(6871):536-41.
2002: Vijay K Kuchroo; Ana C Anderson; Hanspeter Waldner; Markus Munder; Estelle Bettelli; Lindsay B Nicholson
T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire.
Annual review of immunology 2002;20():101-23.
2002: Tammy T Chang; Vijay K Kuchroo; Arlene H Sharpe
Role of the B7-CD28/CTLA-4 pathway in autoimmune disease.
Current directions in autoimmunity 2002;5():113-30.
2001: Jennifer J McIntire; Sarah E Umetsu; Omid Akbari; M Potter; Vijay K Kuchroo; Gregory S Barsh; Gordon J Freeman; Dale T Umetsu; Rosemarie H Dekruyff
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.
Nature immunology 2001;2(12):1109-16.
2001: Jason L Gaglia; A Mattoo; Edward Greenfield; Gordon J Freeman; Vijay K Kuchroo
Characterization of endogenous Chinese hamster ovary cell surface molecules that mediate T cell costimulation.
Cellular immunology 2001;213(2):83-93.
2001: C Stremmel; Mark A Exley; Steven P Balk; W Hohenberger; Vijay K Kuchroo
Characterization of the phenotype and function of CD8(+), alpha / beta(+) NKT cells from tumor-bearing mice that show a natural killer cell activity and lyse multiple tumor targets.
European journal of immunology 2001;31(9):2818-28.
2001: B E Theien; Carol L Vanderlugt; Todd N Eagar; Cheryl Nickerson-Nutter; Remedios F Nazareno; Vijay K Kuchroo; Stephen D Miller
Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis.
The Journal of clinical investigation 2001;107(8):995-1006.
2001: Ana C Anderson; Lindsay B Nicholson; Vijay K Kuchroo
The origin and regulation of autopathogenic T cells.
Journal of clinical immunology 2001;21(2):74-80.
2001: J A Encinas; Marjorie B Lees; Raymond A Sobel; C Symonowicz; Howard L Weiner; C E Seidman; J G Seidman; Vijay K Kuchroo
Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis.
International immunology 2001;13(3):257-64.
2000: Jason L Gaglia; Edward Greenfield; A Mattoo; Arlene H Sharpe; Gordon J Freeman; Vijay K Kuchroo
Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6091-8.
2000: Alexander J McAdam; Tammy T Chang; A E Lumelsky; Edward Greenfield; Vassiliki A Boussiotis; Jonathan S Duke-Cohan; Tatyana Chernova; N Malenkovich; Claudia Jabs; Vijay K Kuchroo; Vincent Ling; Mary Collins; Arlene H Sharpe; Gordon J Freeman
Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5035-40.
2000: Ana C Anderson; Hanspeter Waldner; V Turchin; Claudia Jabs; M Prabhu Das; Vijay K Kuchroo; Lindsay B Nicholson
Autoantigen-responsive T cell clones demonstrate unfocused TCR cross-reactivity toward multiple related ligands: implications for autoimmunity.
Cellular immunology 2000;202(2):88-96.
2000: Hanspeter Waldner; M J Whitters; Raymond A Sobel; M Collins; Vijay K Kuchroo
Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3412-7.
2000: Ana C Anderson; Lindsay B Nicholson; Kevin Legge; V Turchin; Habib Zaghouani; Vijay K Kuchroo
High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire.
The Journal of experimental medicine 2000;191(5):761-70.
2000: Lindsay B Nicholson; Ana C Anderson; Vijay K Kuchroo
Tuning T cell activation threshold and effector function with cross-reactive peptide ligands.
International immunology 2000;12(2):205-13.
1999: Tammy T Chang; Claudia Jabs; Raymond A Sobel; Vijay K Kuchroo; Arlene H Sharpe
Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 1999;190(5):733-40.
1999: Ruth Maron; Wayne W Hancock; Anthony J Slavin; M Hattori; Vijay K Kuchroo; Howard L Weiner
Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines.
International immunology 1999;11(9):1573-80.
1999: L Liu; Vijay K Kuchroo; Howard L Weiner
B7.2 (CD86) but not B7.1 (CD80) costimulation is required for the induction of low dose oral tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2284-90.
1999: C Stremmel; Edward Greenfield; E Howard; Gordon J Freeman; Vijay K Kuchroo
B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism.
The Journal of experimental medicine 1999;189(6):919-30.
1999: A Murtaza; Vijay K Kuchroo; Gordon J Freeman
Changes in the strength of co-stimulation through the B7/CD28 pathway alter functional T cell responses to altered peptide ligands.
International immunology 1999;11(3):407-16.
1999: J A Encinas; Vijay K Kuchroo
Genetics of experimental autoimmune encephalomyelitis.
Current directions in autoimmunity 1999;1():247-72.
1998: Vijay K Kuchroo; Howard L Weiner
Antigen-driven regulation of experimental autoimmune encephalomyelitis.
Research in immunology 1998;149(9):759-71; discussion 842-3, 855-60.
1998: A M Carrizosa; Lindsay B Nicholson; M Farzan; S Southwood; A Sette; Raymond A Sobel; Vijay K Kuchroo
Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(7):3307-14.
1998: Estelle Bettelli; M P Das; E D Howard; Howard L Weiner; Raymond A Sobel; Vijay K Kuchroo
IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(7):3299-306.
1998: Lindsay B Nicholson; Hanspeter Waldner; A M Carrizosa; A Sette; M Collins; Vijay K Kuchroo
Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):264-9.
1998: Edward Greenfield; K A Nguyen; Vijay K Kuchroo
CD28/B7 costimulation: a review.
Critical reviews in immunology 1998;18(5):389-418.
1997: Per Höllsberg; C Scholz; David E Anderson; Edward Greenfield; Vijay K Kuchroo; Gordon J Freeman; David A Hafler
Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):4799-805.
1997: Hanspeter Waldner; Raymond A Sobel; E Howard; Vijay K Kuchroo
Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3100-3.
1997: M P Das; Lindsay B Nicholson; Judith Greer; Vijay K Kuchroo
Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein.
The Journal of experimental medicine 1997;186(6):867-76.
1997: Lindsay B Nicholson; A Murtaza; B P Hafler; Alessandro Sette; Vijay K Kuchroo
A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9279-84.
1997: Edward Greenfield; E Howard; T Paradis; K Nguyen; F Benazzo; P McLean; Per Höllsberg; G Davis; David A Hafler; A H Sharpe; Gordon J Freeman; Vijay K Kuchroo
B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2025-34.
1997: Lindsay B Nicholson; Vijay K Kuchroo
T cell recognition of self and altered self antigens.
Critical reviews in immunology 1997;17(5-6):449-62.
1996: Lara J Ausubel; C K Kwan; Alessandro Sette; Vijay K Kuchroo; David A Hafler
Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15317-22.
1996: Lindsay B Nicholson; Vijay K Kuchroo
Manipulation of the Th1/Th2 balance in autoimmune disease.
Current opinion in immunology 1996;8(6):837-42.
1996: M R Das; A Cohen; Scott S Zamvil; Halina Offner; Vijay K Kuchroo
Prior exposure to superantigen can inhibit or exacerbate autoimmune encephalomyelitis: T-cell repertoire engaged by the autoantigen determines clinical outcome.
Journal of neuroimmunology 1996;71(1-2):3-10.
1996: AM Ranger; M P Das; Vijay K Kuchroo; Laurie H Glimcher
B7-2 (CD86) is essential for the development of IL-4-producing T cells.
International immunology 1996;8(10):1549-60.
1996: J A Encinas; Howard L Weiner; Vijay K Kuchroo
Inheritance of susceptibility to experimental autoimmune encephalomyelitis.
Journal of neuroscience research 1996;45(6):655-69.
1996: J A Encinas; Marjorie B Lees; Raymond A Sobel; C Symonowicz; Judith Greer; C L Shovlin; Howard L Weiner; Christine E Seidman; Jonathan G Seidman; Vijay K Kuchroo
Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):2186-92.
1996: David A Hafler; M G Saadeh; Vijay K Kuchroo; E Milford; L Steinman
TCR usage in human and experimental demyelinating disease.
Immunology today 1996;17(4):152-9.
1996: Yahua Chen; J Inobe; Vijay K Kuchroo; J L Baron; C A Janeway; Howard L Weiner
Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):388-91.
1996: A Windhagen; Lindsay B Nicholson; Howard L Weiner; Vijay K Kuchroo; David A Hafler
Role of Th1 and Th2 cells in neurologic disorders.
Chemical immunology 1996;63():171-86.
1996: Judith Greer; Raymond A Sobel; Alessandro Sette; S Southwood; Marjorie B Lees; Vijay K Kuchroo
Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(1):371-9.
1995: Lindsay B Nicholson; Judith Greer; Raymond A Sobel; Marjorie B Lees; Vijay K Kuchroo
An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis.
Immunity 1995;3(4):397-405.
1995: Silva Markovic-Plese; H Fukaura; J Zhang; A al-Sabbagh; S Southwood; Alessandro Sette; Vijay K Kuchroo; David A Hafler
T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(2):982-92.
1995: Yahua Chen; J Inobe; R Marks; Patricia A Gonnella; Vijay K Kuchroo; Howard L Weiner
Peripheral deletion of antigen-reactive T cells in oral tolerance.
Nature 1995;376(6536):177-80.
1995: Vijay K Kuchroo; M C Byrne; E Greenfield; M J Whitters; E A Nalefsky; Anjana Rao; M Collins; Martin E Dorf
Transfection of TCR alpha-chains into suppressor and T helper cell hybridomas. Production of suppressor factors with predicted antigen specificity.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5030-8.
1995: Vijay K Kuchroo; M P Das; J A Brown; AM Ranger; Scott S Zamvil; Raymond A Sobel; Howard L Weiner; N Nabavi; Laurie H Glimcher
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy.
Cell 1995;80(5):707-18.
1995: R M O'Hara; M C Byrne; Vijay K Kuchroo; A Nagelin; M J Whitters; S Jayaraman; S L Henderson; Martin E Dorf; M Collins
T cell receptor alpha-chain defines the antigen specificity of antigen-specific suppressor factor but does not impart genetic restriction.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(5):2075-81.
1995: M R Prabhu Das; Scott S Zamvil; F Borriello; Howard L Weiner; Arlene H Sharpe; Vijay K Kuchroo
Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation.
European journal of immunology 1995;25(1):207-11.
1994: Vijay K Kuchroo; Judith Greer; D Kaul; Glenn Ishioka; A Franco; Alessandro Sette; Raymond A Sobel; Marjorie B Lees
A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(7):3326-36.
1994: Yahua Chen; Vijay K Kuchroo; J Inobe; David A Hafler; Howard L Weiner
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis.
Science (New York, N.Y.) 1994;265(5176):1237-40.
1994: Raymond A Sobel; Judith Greer; Vijay K Kuchroo
Minireview: autoimmune responses to myelin proteolipid protein.
Neurochemical research 1994;19(8):915-21.
1994: Vijay K Kuchroo; M Collins; A al-Sabbagh; Raymond A Sobel; M J Whitters; Scott S Zamvil; Martin E Dorf; David A Hafler; Jonathan G Seidman; Howard L Weiner
T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice.
The Journal of experimental medicine 1994;179(5):1659-64.
1994: Scott S Zamvil; A al-Sabbagh; P A Nelson; D Kaul; M S Charles; Dennis J Mitchell; Lawrence Steinman; Howard L Weiner; Vijay K Kuchroo
'Lupus-prone' mice are susceptible to organ-specific autoimmune disease, experimental allergic encephalomyelitis.
Pathobiology : journal of immunopathology, molecular and cellular biology 1994;62(3):113-9.
1993: Vijay K Kuchroo; C A Martin; Judith Greer; S T Ju; Raymond A Sobel; Martin E Dorf
Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(8):4371-82.
1992: Judith Greer; Vijay K Kuchroo; Raymond A Sobel; Marjorie B Lees
Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(3):783-8.
1992: Martin E Dorf; Vijay K Kuchroo; M Collins
Suppressor T cells: some answers but more questions.
Immunology today 1992;13(7):241-3.
1992: Vijay K Kuchroo; Raymond A Sobel; J C Laning; C A Martin; E Greenfield; Martin E Dorf; Marjorie B Lees
Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor V beta usage.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(12):3776-82.
1991: Vijay K Kuchroo; M C Byrne; Y Atsumi; E Greenfield; J B Connolly; M J Whitters; R M O'Hara; M Collins; Martin E Dorf
T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8700-4.
1991: Vijay K Kuchroo; Raymond A Sobel; T Yamamura; E Greenfield; Martin E Dorf; Marjorie B Lees
Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides.
Pathobiology : journal of immunopathology, molecular and cellular biology 1991;59(5):305-12.
1990: M J Gallina; Vijay K Kuchroo; J K Steele
Serologic, biologic, and western blot analysis of a T suppressor factor with specificity for the hapten 4-hydroxy-3-nitrophenyl acetyl derived from serum-free medium.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(11):3570-7.
1990: M Collins; Vijay K Kuchroo; M J Whitters; R M O'Hara; K Kelleher; R T Kubo; Martin E Dorf
Expression of functional alpha beta T cell receptor gene rearrangements in suppressor T cell hybridomas correlates with antigen binding, but not with suppressor cell function.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(9):2809-19.
1990: S D Wilson; Vijay K Kuchroo; D I Israel; Martin E Dorf
Expression and characterization of TCA3: a murine inflammatory protein.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(8):2745-50.
1990: Vijay K Kuchroo; P R Billings; C Levine; C A Martin; R T Kubo; Martin E Dorf
Antigen-specific and antibody-mediated growth inhibition of suppressor T cell hybridomas. Roles of H-2 and the CD3-T cell receptor-alpha/beta complex.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(4):1059-65.
1990: Vijay K Kuchroo; J K Steele; R M O'Hara; S Jayaraman; Periasamy Selvaraj; E Greenfield; R T Kubo; Martin E Dorf
Relationships between antigen-specific helper and inducer suppressor T cell hybridomas.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(2):438-48.
1989: H Ishikura; S Jayaraman; Vijay K Kuchroo; Betty Diamond; S Saito; Martin E Dorf
Functional analysis of cloned macrophage hybridomas. VII. Modulation of suppressor T cell-inducing activity.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(2):414-9.
1989: Vijay K Kuchroo; M Minami; Betty Diamond; Martin E Dorf
Requirements for suppressor cell activation. Role of accessory cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2192-9.
1989: J K Steele; Vijay K Kuchroo; H Kawasaki; S Jayaraman; M Iwata; KIMISHIGE ISHIZAKA; Martin E Dorf
A monoclonal antibody raised to lipomodulin recognizes T suppressor factors in two independent hapten-specific suppressor networks.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(7):2213-20.
1988: H Ishikura; Vijay K Kuchroo; Sara R Abromson-Leeman; Martin E Dorf
Comparisons between helper and suppressor T-cell induction.
Immunological reviews 1988;106():93-114.
1988: Vijay K Kuchroo; J K Steele; P R Billings; Periasamy Selvaraj; Martin E Dorf
Expression of CD3-associated antigen-binding receptors on suppressor T cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9209-13.
1988: Martin E Dorf; Vijay K Kuchroo; J K Steele; R M O'Hara
Understanding suppressor cells: where have we gone wrong?
International reviews of immunology 1988;3(4):375-92.
1988: Vijay K Kuchroo; T Noma; M Minami; Martin E Dorf
Down-regulation of suppressor cell induction.
Immunology 1988;64(4):633-42.
1988: Vijay K Kuchroo; M Minami; Betty Diamond; Martin E Dorf
Functional analysis of cloned macrophage hybridomas. VI. Differential ability to induce immunity or suppression.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):10-6.
1987: J K Steele; H Kawasaki; Vijay K Kuchroo; M Minami; JG Levy; Martin E Dorf
A monoclonal antibody raised to tumor-specific T cell-derived suppressor factors also recognizes T suppressor inducer factors of the 4-hydroxy-3-nitrophenyl acetyl hapten suppressor network.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2629-34.