Klaus Kuettner

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Anatomy

Chemicals & Drugs

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Osteoarthritis

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Rolauffs Bernd; Williams James M; Grodzinsky Alan J; Kuettner Klaus E; Cole Ada A
Distinct horizontal patterns in the spatial organization of superficial zone chondrocytes of human joints.
Patwari Parth; Cheng Debbie M; Cole Ada A; Kuettner Klaus E; Grodzinsky Alan J
Analysis of the relationship between peak stress and proteoglycan loss following injurious compression of human post-mortem knee and ankle cartilage.
Aurich M; Eger W; Rolauffs B; Margulis A; Kuettner K E; Mollenhauer J A; Cole A A
[Ankle chondrocytes are more resistant to Interleukin-1 than chondrocytes derived from the knee]

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All Publications

2008: Rolauffs Bernd; Williams James M; Grodzinsky Alan J; Kuettner Klaus E; Cole Ada A
Distinct horizontal patterns in the spatial organization of superficial zone chondrocytes of human joints.
Journal of structural biology 2008;162(2):335-44.
2007: Patwari Parth; Cheng Debbie M; Cole Ada A; Kuettner Klaus E; Grodzinsky Alan J
Analysis of the relationship between peak stress and proteoglycan loss following injurious compression of human post-mortem knee and ankle cartilage.
Biomechanics and modeling in mechanobiology 2007;6(1-2):83-9.
2006: Aurich M; Eger W; Rolauffs B; Margulis A; Kuettner K E; Mollenhauer J A; Cole A A
[Ankle chondrocytes are more resistant to Interleukin-1 than chondrocytes derived from the knee]
Der Orthopäde 2006;35(7):784-90.
2006: Aurich Matthias; Mwale Fackson; Reiner Agnes; Mollenhauer Juergen A; Anders Jens O; Fuhrmann Reneé A; Kuettner Klaus E; Poole A Robin; Cole Ada A
Collagen and proteoglycan turnover in focally damaged human ankle cartilage: evidence for a generalized response and active matrix remodeling across the entire joint surface.
Arthritis and rheumatism 2006;54(1):244-52.
2005: Li Jun; Williams James M; Zhong Zhong; Kuettner Klaus E; Aurich Matthias; Mollenhauer Juergen; Muehleman Carol
Reliability of diffraction enhanced imaging for assessment of cartilage lesions, ex vivo.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2005;13(3):187-97.
2005: Kuettner K E; Cole A A
Cartilage degeneration in different human joints.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2005;13(2):93-103.
2005: Söder Stephan; Hakimiyan Arnavaz; Rueger David C; Kuettner Klaus E; Aigner Thomas; Chubinskaya Susan
Antisense inhibition of osteogenic protein 1 disturbs human articular cartilage integrity.
Arthritis and rheumatism 2005;52(2):468-78.
2005: Aurich Matthias; Squires Ginette R; Reiner Agnes; Mollenhauer Juergen A; Kuettner Klaus E; Poole A Robin; Cole Ada A
Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints.
Arthritis and rheumatism 2005;52(1):112-9.
2004: Muehleman C; Li J; Wernick M; Brankov J; Kuettner K; Zhong Z
Yes, you can see cartilage with X-rays; diffraction enhanced X-ray imaging for soft and hard tissues.
Journal of musculoskeletal & neuronal interactions 2004;4(4):369-70.
2004: Li Jun; Zhong Zhong; Lidtke Roy; Kuettner Klaus E; Peterfy Charles; Aliyeva Elmira; Muehleman Carol
Radiography of soft tissue of the foot and ankle with diffraction enhanced imaging.
Journal of the American Podiatric Medical Association 2004;94(3):315-22.
2004: Muehleman Carol; Majumdar Sharmila; Issever Ahi Sema; Arfelli Fulvia; Menk Ralf Hendrik; Rigon Luigi; Heitner Gabriele; Reime Bernd; Metge Joachim; Wagner Andreas; Kuettner Klaus E; Mollenhauer Juergen
X-ray detection of structural orientation in human articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(2):97-105.
2003: Merrihew Charis; Kumar Bhavna; Heretis Katherine; Rueger David C; Kuettner Klaus E; Chubinskaya Susan
Alterations in endogenous osteogenic protein-1 with degeneration of human articular cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(5):899-907.
2003: Chubinskaya Susan; Kuettner Klaus E
Regulation of osteogenic proteins by chondrocytes.
The international journal of biochemistry & cell biology 2003;35(9):1323-40.
2003: Cole Ada A; Margulis Arkady; Kuettner Klaus E
Distinguishing ankle and knee articular cartilage.
Foot and ankle clinics 2003;8(2):305-16, x.
2003: Li Jun; Zhong Zhong; Lidtke Roy; Kuettner Klaus E; Peterfy Charles; Aliyeva Elmira; Muehleman Carol
Radiography of soft tissue of the foot and ankle with diffraction enhanced imaging.
Journal of anatomy 2003;202(5):463-70.
2003: Muehleman Carol; Chapman L Dean; Kuettner Klaus E; Rieff Joel; Mollenhauer Juergen A; Massuda Koichi; Zhong Zhong
Radiography of rabbit articular cartilage with diffraction-enhanced imaging.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2003;272(1):392-7.
2003: Eger Wolfgang; Aurich Matthias; Schumacher Barbara L; Mollenhauer Jürgen; Kuettner Klaus E; Cole Ada A
[Differences in metabolism of chondrocytes of the knee and ankle joint]
Zeitschrift für Orthopädie und ihre Grenzgebiete 2003;141(1):18-20.
2003: Merrihew Charis; Soeder Stephan; Rueger David C; Kuettner Klaus E; Chubinskaya Susan
Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage.
The Journal of bone and joint surgery. American volume 2003;85-A Suppl 3():67-74.
2002: Aurich Matthias; Poole A Robin; Reiner Agnes; Mollenhauer Christine; Margulis Arkady; Kuettner Klaus E; Cole Ada A
Matrix homeostasis in aging normal human ankle cartilage.
Arthritis and rheumatism 2002;46(11):2903-10.
2002: Chubinskaya Susan; Kumar Bhavna; Merrihew Charis; Heretis Katherine; Rueger David C; Kuettner Klaus E
Age-related changes in cartilage endogenous osteogenic protein-1 (OP-1).
Biochimica et biophysica acta 2002;1588(2):126-34.
2002: Muehleman Carol; Kuettner Klaus E; Rueger David C; Ten Dijke Peter; Chubinskaya Susan
Immunohistochemical localization of osteogenetic protein (OP-1) and its receptors in rabbit articular cartilage.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002;50(10):1341-50.
2002: Eger Wolfgang; Schumacher Barbara L; Mollenhauer Jürgen; Kuettner Klaus E; Cole Ada A
Human knee and ankle cartilage explants: catabolic differences.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(3):526-34.
2002: Schumacher Barbara L; Su Jui-Lan; Lindley Kathy M; Kuettner Klaus E; Cole Ada A
Horizontally oriented clusters of multiple chondrons in the superficial zone of ankle, but not knee articular cartilage.
The Anatomical record 2002;266(4):241-8.
2002: Muehleman C; Green J; Williams J M; Kuettner K E; Thonar E J-M A; Sumner D R
The effect of bone remodeling inhibition by zoledronic acid in an animal model of cartilage matrix damage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(3):226-33.
2002: Mollenhauer J; Aurich M E; Zhong Z; Muehleman C; Cole A A; Hasnah M; Oltulu O; Kuettner K E; Margulis A; Chapman L D
Diffraction-enhanced X-ray imaging of articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(3):163-71.
2002: Muehleman C; Berzins A; Koepp H; Eger W; Cole A A; Kuettner K E; Sumner D R
Bone density of the human talus does not increase with the cartilage degeneration score.
The Anatomical record 2002;266(2):81-6.
2002: Kerin A; Patwari P; Kuettner K; Cole A; Grodzinsky A
Molecular basis of osteoarthritis: biomechanical aspects.
Cellular and molecular life sciences : CMLS 2002;59(1):27-35.
2002: Cole A A; Kuettner K E
Molecular basis for differences between human joints.
Cellular and molecular life sciences : CMLS 2002;59(1):19-26.
2001: Pfister B E; Aydelotte M B; Burkhart W; Kuettner K E; Schmid T M
Del1: a new protein in the superficial layer of articular cartilage.
Biochemical and biophysical research communications 2001;286(2):268-73.
2000: Muehleman C; Kuettner K E
Distribution of cartilage thickness on the head of the human first metatarsal bone.
Journal of anatomy 2000;197 Pt 4():687-91.
2000: Treppo S; Koepp H; Quan E C; Cole A A; Kuettner K E; Grodzinsky A J
Comparison of biomechanical and biochemical properties of cartilage from human knee and ankle pairs.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(5):739-48.
2000: Knudson W; Casey B; Nishida Y; Eger W; Kuettner K E; Knudson C B
Hyaluronan oligosaccharides perturb cartilage matrix homeostasis and induce chondrocytic chondrolysis.
Arthritis and rheumatism 2000;43(5):1165-74.
2000: Nishida Y; Knudson C B; Kuettner K E; Knudson W
Osteogenic protein-1 promotes the synthesis and retention of extracellular matrix within bovine articular cartilage and chondrocyte cultures.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(2):127-36.
2000: Schulze M; Kuettner K E; Cole A A
[Adult human chondrocytes in alginate culture. Preservation of the phenotype for further use in transplantation models]
Der Orthopäde 2000;29(2):100-6.
2000: Chubinskaya S; Merrihew C; Cs-Szabo G; Mollenhauer J; McCartney J; Rueger D C; Kuettner K E
Human articular chondrocytes express osteogenic protein-1.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(2):239-50.
2000: Nishida Y; Knudson C B; Eger W; Kuettner K E; Knudson W
Osteogenic protein 1 stimulates cells-associated matrix assembly by normal human articular chondrocytes: up-regulation of hyaluronan synthase, CD44, and aggrecan.
Arthritis and rheumatism 2000;43(1):206-14.
1999: Chubinskaya S; Kuettner K E; Cole A A
Expression of matrix metalloproteinases in normal and damaged articular cartilage from human knee and ankle joints.
Laboratory investigation; a journal of technical methods and pathology 1999;79(12):1669-77.
1999: Kang Y; Eger W; Koepp H; Williams J M; Kuettner K E; Homandberg G A
Hyaluronan suppresses fibronectin fragment-mediated damage to human cartilage explant cultures by enhancing proteoglycan synthesis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1999;17(6):858-69.
1999: Koepp H E; Sampath K T; Kuettner K E; Homandberg G A
Osteogenic protein-1 (OP-1) blocks cartilage damage caused by fibronectin fragments and promotes repair by enhancing proteoglycan synthesis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1999;48(4):199-204.
1999: Schumacher B L; Hughes C E; Kuettner K E; Caterson B; Aydelotte M B
Immunodetection and partial cDNA sequence of the proteoglycan, superficial zone protein, synthesized by cells lining synovial joints.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1999;17(1):110-20.
1999: Flannery C R; Hughes C E; Schumacher B L; Tudor D; Aydelotte M B; Kuettner K E; Caterson B
Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism.
Biochemical and biophysical research communications 1999;254(3):535-41.
1999: Koepp H; Eger W; Muehleman C; Valdellon A; Buckwalter J A; Kuettner K E; Cole A A
Prevalence of articular cartilage degeneration in the ankle and knee joints of human organ donors.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 1999;4(6):407-12.
1998: Kang Y; Koepp H; Cole A A; Kuettner K E; Homandberg G A
Cultured human ankle and knee cartilage differ in susceptibility to damage mediated by fibronectin fragments.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1998;16(5):551-6.
1998: Chubinskaya S; Cs-Szabo G; Kuettner K E
ADAM-10 message is expressed in human articular cartilage.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(6):723-9.
1997: Huch K; Wilbrink B; Flechtenmacher J; Koepp H E; Aydelotte M B; Sampath T K; Kuettner K E; Mollenhauer J; Thonar E J
Effects of recombinant human osteogenic protein 1 on the production of proteoglycan, prostaglandin E2, and interleukin-1 receptor antagonist by human articular chondrocytes cultured in the presence of interleukin-1beta.
Arthritis and rheumatism 1997;40(12):2157-61.
1997: Muehleman C; Chubinskaya S; Cole A A; Noskina Y; Arsenis C; Kuettner K E
1997 William J. Stickel Gold Award. Morphological and biochemical properties of metatarsophalangeal joint cartilage.
Journal of the American Podiatric Medical Association 1997;87(10):447-59.
1997: Homandberg G A; Hui F; Wen C; Kuettner K E; Williams J M
Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis: I. In vitro.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1997;5(5):309-19.
1997: Williams J M; Plaza V; Hui F; Wen C; Kuettner K E; Homandberg G A
Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis: II. In vivo.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1997;5(4):235-40.
1997: Büttner F H; Chubinskaya S; Margerie D; Huch K; Flechtenmacher J; Cole A A; Kuettner K E; Bartnik E
Expression of membrane type 1 matrix metalloproteinase in human articular cartilage.
Arthritis and rheumatism 1997;40(4):704-9.
1997: Huch K; Kuettner K E; Dieppe P
Osteoarthritis in ankle and knee joints.
Seminars in arthritis and rheumatism 1997;26(4):667-74.
1997: Muehleman C; Bareither D; Huch K; Cole A A; Kuettner K E
Prevalence of degenerative morphological changes in the joints of the lower extremity.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1997;5(1):23-37.
1996: Flechtenmacher J; Huch K; Thonar E J; Mollenhauer J A; Davies S R; Schmid T M; Puhl W; Sampath T K; Aydelotte M B; Kuettner K E
Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes.
Arthritis and rheumatism 1996;39(11):1896-904.
1996: Cole A A; Chubinskaya S; Schumacher B; Huch K; Szabo G; Yao J; Mikecz K; Hasty K A; Kuettner K E
Chondrocyte matrix metalloproteinase-8. Human articular chondrocytes express neutrophil collagenase.
The Journal of biological chemistry 1996;271(18):11023-6.
1996: Hauselmann H J; Flechtenmacher J; Michal L; Thonar E J; Shinmei M; Kuettner K E; Aydelotte M B
The superficial layer of human articular cartilage is more susceptible to interleukin-1-induced damage than the deeper layers.
Arthritis and rheumatism 1996;39(3):478-88.
1996: Chubinskaya S; Huch K; Mikecz K; Cs-Szabo G; Hasty K A; Kuettner K E; Cole A A
Chondrocyte matrix metalloproteinase-8: up-regulation of neutrophil collagenase by interleukin-1 beta in human cartilage from knee and ankle joints.
Laboratory investigation; a journal of technical methods and pathology 1996;74(1):232-40.
1995: Cole A A; Kuettner K E
MMP-8 (neutrophil collagenase) mRNA and aggrecanase cleavage products are present in normal and osteoarthritic human articular cartilage.
Acta orthopaedica Scandinavica. Supplementum 1995;266():98-102.
1995: Yao J; Glant T T; Lark M W; Mikecz K; Jacobs J J; Hutchinson N I; Hoerrner L A; Kuettner K E; Galante J O
The potential role of fibroblasts in periprosthetic osteolysis: fibroblast response to titanium particles.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995;10(9):1417-27.
1995: Thonar E J; Masuda K; Lenz M E; Hauselmann H J; Kuettner K E; Manicourt D H
Serum markers of systemic disease processes in osteoarthritis.
The Journal of rheumatology. Supplement 1995;43():68-70.
1994: Cole A A; Chubinskaya S; Luchene L J; Chlebek K; Orth M W; Greenwald R A; Kuettner K E; Schmid T M
Doxycycline disrupts chondrocyte differentiation and inhibits cartilage matrix degradation.
Arthritis and rheumatism 1994;37(12):1727-34.
1994: Böhm B B; Wilbrink B; Kuettner K E; Mollenhauer J
Structural and functional comparison of anchorin CII (cartilage annexin V) and muscle annexin V.
Archives of biochemistry and biophysics 1994;314(1):64-74.
1994: Schumacher B L; Block J A; Schmid T M; Aydelotte M B; Kuettner K E
A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage.
Archives of biochemistry and biophysics 1994;311(1):144-52.
1994: Häuselmann H J; Fernandes R J; Mok S S; Schmid T M; Block J A; Aydelotte M B; Kuettner K E; Thonar E J
Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads.
Journal of cell science 1994;107 ( Pt 1)():17-27.
1993: Cole A A; Boyd T; Luchene L; Kuettner K E; Schmid T M
Type X collagen degradation in long-term serum-free culture of the embryonic chick tibia following production of active collagenase and gelatinase.
Developmental biology 1993;159(2):528-34.
1992: Häuselmann H J; Aydelotte M B; Schumacher B L; Kuettner K E; Gitelis S H; Thonar E J
Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads.
Matrix (Stuttgart, Germany) 1992;12(2):116-29.
1992: Glant T T; Mikecz K; Bartlett R R; Deák F; Thonar E J; Williams J M; Mattar T; Kuettner K E; Schleyerbach R
Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomide.
Immunopharmacology 1992;23(2):105-16.
1992: Aydelotte M B; Raiss R X; Caterson B; Kuettner K E
Influence of interleukin-1 on the morphology and proteoglycan metabolism of cultured bovine articular chondrocytes.
Connective tissue research 1992;28(1-2):143-59.
1991: Kang K; Schwarz D; Sky-Peck H; Kuettner K E; Homandberg G A
Novel method of purification of human leukocytic elastase using adsorption on a high-performance liquid chromatography gel permeation column.
Journal of chromatography 1991;567(1):57-63.
1991: Kuettner K E; Aydelotte M B; Thonar E J
Articular cartilage matrix and structure: a minireview.
The Journal of rheumatology. Supplement 1991;27():46-8.
1991: Thonar E J; Manicourt D M; Williams J; Lenz M E; Sweet M B; Schnitzer T J; Otten L; Glant T; Kuettner K E
Circulating keratan sulfate: a marker of cartilage proteoglycan catabolism in osteoarthritis.
The Journal of rheumatology. Supplement 1991;27():24-6.
1990: Kucharska A M; Kuettner K E; Kimura J H
Biochemical characterization of long-term culture of the Swarm rat chondrosarcoma chondrocytes in agarose.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1990;8(6):781-92.
1989: Kuettner K E; Thonar E J; Aydelotte M B
Metabolism of articular cartilage chondrocytes.
Nippon Seikeigeka Gakkai zasshi 1989;63(5):621-9.
1988: Sweet M B; Coelho A; Schnitzler C M; Schnitzer T J; Lenz M E; Jakim I; Kuettner K E; Thonar E J
Serum keratan sulfate levels in osteoarthritis patients.
Arthritis and rheumatism 1988;31(5):648-52.
1988: Arsenis C; Kuettner K E; Eisenstein R
Isolation and partial characterization of neutrophil elastase inhibitors from bovine vitreous and aorta.
Current eye research 1988;7(2):95-102.
1988: Thonar E J; Pachman L M; Lenz M E; Hayford J; Lynch P; Kuettner K E
Age related changes in the concentration of serum keratan sulphate in children.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie 1988;26(2):57-63.
1988: Thonar E J; Feist S B; Fassbender K; Lenz M E; Matijevitch B L; Kuettner K E
Quantification of hen egg white lysozyme in cartilage by an enzyme-linked immunosorbent assay.
Connective tissue research 1988;17(3):181-97.
1988: Aydelotte M B; Greenhill R R; Kuettner K E
Differences between sub-populations of cultured bovine articular chondrocytes. II. Proteoglycan metabolism.
Connective tissue research 1988;18(3):223-34.
1988: Aydelotte M B; Kuettner K E
Differences between sub-populations of cultured bovine articular chondrocytes. I. Morphology and cartilage matrix production.
Connective tissue research 1988;18(3):205-22.
1986: Klintworth G K; Meyer R; Dennis R; Hewitt A T; Stock E L; Lenz M E; Hassell J R; Stark W J; Kuettner K E; Thonar E J
Macular corneal dystrophy. Lack of keratan sulfate in serum and cornea.
Ophthalmic paediatrics and genetics 1986;7(3):139-43.
1986: Thonar E J; Meyer R F; Dennis R F; Lenz M E; Maldonado B; Hassell J R; Hewitt A T; Stark W J; Stock E L; Kuettner K E
Absence of normal keratan sulfate in the blood of patients with macular corneal dystrophy.
American journal of ophthalmology 1986;102(5):561-9.
1986: Skosey J L; Arsenis C; Kuettner K E; Chow D C
Neutrophil enzymes, antiproteases, and oxygen radicals: interaction in cartilage proteoglycan degradation and effect of D-penicillamine.
Agents and actions. Supplements 1986;18():83-8.
1986: Arsenis C; Thonar E J; Kuettner K E
Degradation of cartilage matrix by purified elastase and its control by an endogenous purified specific cartilage elastase inhibitor.
Agents and actions. Supplements 1986;18():63-8.
1986: Sun D; Aydelotte M B; Maldonado B; Kuettner K E; Kimura J H
Clonal analysis of the population of chondrocytes from the Swarm rat chondrosarcoma in agarose culture.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1986;4(4):427-36.
1985: Thonar E J; Lenz M E; Klintworth G K; Caterson B; Pachman L M; Glickman P; Katz R; Huff J; Kuettner K E
Quantification of keratan sulfate in blood as a marker of cartilage catabolism.
Arthritis and rheumatism 1985;28(12):1367-76.

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