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Jürgen Kuhlmann
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Research Profile (preview)
Chemicals & Drugs
Anatomy
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Network (preview)
20
Waldmann, Herbert
7
Wittinghofer, Alfred
6
Popkirova, Boriana
4
Wagner, Melanie
4
Alexandrov, Kirill
4
Grunwald, Christian
4
Nowak, Christine
3
Niemeyer, Christof
3
Köhn, Maja
3
Goody, Roger
3
Breinbauer, Rolf
3
Brunsveld, Luc
3
Wacker, Ron
3
Schlummer, Stefanie
2
Schroeder, Hendrik
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Publications
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Geonetwork of Jürgen Kuhlmann (preview)
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All Publications
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2009: Rucktäschel Robert; Thoms Sven; Sidorovitch Vadim; Halbach Andre; Pechlivanis Markos; Volkmer Rudolf; Alexandrov Kirill; Kuhlmann Jürgen; Rottensteiner Hanspeter; Erdmann Ralf
Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis.
The Journal of biological chemistry 2009;284(31):20885-96.
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2009: Alexander Michael; Gerauer Marc; Pechlivanis Markos; Popkirova Boriana; Dvorsky Radovan; Brunsveld Luc; Waldmann Herbert; Kuhlmann Jürgen
Mapping the isoprenoid binding pocket of PDEdelta by a semisynthetic, photoactivatable N-Ras lipoprotein.
Chembiochem : a European journal of chemical biology 2009;10(1):98-108.
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2008: Güldenhaupt Jörn; Adigüzel Yekbun; Kuhlmann Jürgen; Waldmann Herbert; Kötting Carsten; Gerwert Klaus
Secondary structure of lipidated Ras bound to a lipid bilayer.
The FEBS journal 2008;275(23):5910-8.
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2008: Borza Alexandra; Plöttner Sabine; Wolf Alexander; Behm Claudia; Selinski Silvia; Hengstler Jan G; Roos Peter H; Bolt Hermann M; Kuhlmann Jürgen; Föllmann Wolfram
Synergism of aromatic amines and benzo[a]pyrene in induction of Ah receptor-dependent genes.
Archives of toxicology 2008;82(12):973-80.
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2008: Jonkheijm Pascal; Weinrich Dirk; Köhn Maja; Engelkamp Hans; Christianen Peter C M; Kuhlmann Jürgen; Maan Jan C; Nüsse Dirk; Schroeder Hendrik; Wacker Ron; Breinbauer Rolf; Niemeyer Christof M; Waldmann Herbert
Photochemical surface patterning by the thiol-ene reaction.
Angewandte Chemie (International ed. in English) 2008;47(23):4421-4.
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2007: Pechlivanis Markos; Ringel Rieke; Popkirova Boriana; Kuhlmann Juergen
Prenylation of Ras facilitates hSOS1-promoted nucleotide exchange, upon Ras binding to the regulatory site.
Biochemistry 2007;46(18):5341-8.
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2007: Saric Marc; Zhao Xiaodong; Körner Carolin; Nowak Christine; Kuhlmann Jürgen; Vetter Ingrid R
Structural and biochemical characterization of the Importin-beta.Ran.GTP.RanBD1 complex.
FEBS letters 2007;581(7):1369-76.
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2006: Pechlivanis Markos; Kuhlmann Juergen
Hydrophobic modifications of Ras proteins by isoprenoid groups and fatty acids--More than just membrane anchoring.
Biochimica et biophysica acta 2006;1764(12):1914-31.
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2006: Brunsveld Luc; Kuhlmann Jürgen; Alexandrov Kirill; Wittinghofer Alfred; Goody Roger S; Waldmann Herbert
Lipidated ras and rab peptides and proteins--synthesis, structure, and function.
Angewandte Chemie (International ed. in English) 2006;45(40):6622-46.
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2006: Brunsveld L; Kuhlmann J; Waldmann H
Synthesis of palmitoylated Ras-peptides and -proteins.
Methods (San Diego, Calif.) 2006;40(2):151-65.
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2006: Badura Adrian; Esper Berndt; Ataka Kenichi; Grunwald Christian; Wöll Christof; Kuhlmann Jürgen; Heberle Joachim; Rögner Matthias
Light-driven water splitting for (bio-)hydrogen production: photosystem 2 as the central part of a bioelectrochemical device.
Photochemistry and photobiology 2006;82(5):1385-90.
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2006: Watzke Anja; Gutierrez-Rodriguez Marta; Köhn Maja; Wacker Ron; Schroeder Hendrik; Breinbauer Rolf; Kuhlmann Jürgen; Alexandrov Kirill; Niemeyer Christof M; Goody Roger S; Waldmann Herbert
A generic building block for C- and N-terminal protein-labeling and protein-immobilization.
Bioorganic & medicinal chemistry 2006;14(18):6288-306.
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2006: Hermkes Rebecca; Funke Silke; Richter Christine; Kuhlmann Jürgen; Schünemann Danja
The alpha-helix of the second chromodomain of the 43 kDa subunit of the chloroplast signal recognition particle facilitates binding to the 54 kDa subunit.
FEBS letters 2006;580(13):3107-11.
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2006: Watzke Anja; Köhn Maja; Gutierrez-Rodriguez Marta; Wacker Ron; Schröder Hendrik; Breinbauer Rolf; Kuhlmann Jürgen; Alexandrov Kirill; Niemeyer Christof M; Goody Roger S; Waldmann Herbert
Site-selective protein immobilization by Staudinger ligation.
Angewandte Chemie (International ed. in English) 2006;45(9):1408-12.
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2006: Gottlieb D; Grunwald C; Nowak C; Kuhlmann J; Waldmann H
Intein-mediated in vitro synthesis of lipidated Ras proteins.
Chemical communications (Cambridge, England) 2006;(3):260-2.
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2006: Nicolini Chiara; Baranski Jörg; Schlummer Stefanie; Palomo José; Lumbierres-Burgues Maria; Kahms Martin; Kuhlmann Jürgen; Sanchez Susana; Gratton Enrico; Waldmann Herbert; Winter Roland
Visualizing association of N-ras in lipid microdomains: influence of domain structure and interfacial adsorption.
Journal of the American Chemical Society 2006;128(1):192-201.
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2006: Schlummer Stefanie; Vetter Robin; Kuder Norman; Henkel Andreas; Chen Yong-Xiang; Li Yan-Mei; Kuhlmann Jürgen; Waldmann Herbert
Influence of serine O-glycosylation or O-phosphorylation close to the vJun nuclear localisation sequence on nuclear import.
Chembiochem : a European journal of chemical biology 2006;7(1):88-97.
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2005: Grunwald Christian; Kuhlmann Jürgen; Wöll Christof
In deuterated water the unspecific adsorption of proteins is significantly slowed down: results of an SPR study using model organic surfaces.
Langmuir : the ACS journal of surfaces and colloids 2005;21(20):9017-9.
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2005: Deck Patrick; Pendzialek Dirk; Biel Markus; Wagner Melanie; Popkirova Boriana; Ludolph Björn; Kragol Goran; Kuhlmann Jürgen; Giannis Athanassios; Waldmann Herbert
Development and biological evaluation of acyl protein thioesterase 1 (APT1) inhibitors.
Angewandte Chemie (International ed. in English) 2005;44(31):4975-80.
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2005: Zybin Alexander; Grunwald Christian; Mirsky Vladimir M; Kuhlmann Jürgen; Wolfbeis Otto S; Niemax Kay
Double-wavelength technique for surface plasmon resonance measurements: basic concept and applications for single sensors and two-dimensional sensor arrays.
Analytical chemistry 2005;77(8):2393-9.
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2005: Rocks Oliver; Peyker Anna; Kahms Martin; Verveer Peter J; Koerner Carolin; Lumbierres Maria; Kuhlmann Jürgen; Waldmann Herbert; Wittinghofer Alfred; Bastiaens Philippe I H
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.
Science (New York, N.Y.) 2005;307(5716):1746-52.
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2005: Wolf Alexander; Kutz Alexandra; Plöttner Sabine; Behm Claudia; Bolt Herrmann M; Föllmann Wolfram; Kuhlmann Jürgen
The effect of benzo(a)pyrene on porcine urinary bladder epithelial cells analyzed for the expression of selected genes and cellular toxicological endpoints.
Toxicology 2005;207(2):255-69.
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2005: Reents Reinhard; Wagner Melanie; Schlummer Stefanie; Kuhlmann Jürgen; Waldmann Herbert
Synthesis and application of fluorescent ras proteins for live-cell imaging.
Chembiochem : a European journal of chemical biology 2005;6(1):86-94.
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2004: Peters Carsten; Wolf Alexander; Wagner Melanie; Kuhlmann Jürgen; Waldmann Herbert
The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8531-6.
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2004: Reents Reinhard; Wagner Melanie; Kuhlmann Jürgen; Waldmann Herbert
Synthesis and application of fluorescence-labeled Ras-proteins for live-cell imaging.
Angewandte Chemie (International ed. in English) 2004;43(20):2711-4.
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2004: Wagner Melanie; Kuhlmann Jürgen
Generation and characterization of ras lipoproteins based on chemical coupling.
Methods in molecular biology (Clifton, N.J.) 2004;283():245-54.
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2004: Kuhlmann Jürgen
Protein lipidation.
Methods in molecular biology (Clifton, N.J.) 2004;283():217-20.
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2003: Völkert Martin; Uwai Koji; Tebbe Andreas; Popkirova Boriana; Wagner Melanie; Kuhlmann Jürgen; Waldmann Herbert
Synthesis and biological activity of photoactivatable N-ras peptides and proteins.
Journal of the American Chemical Society 2003;125(42):12749-58.
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2003: Thutewohl Michael; Kissau Lars; Popkirova Boriana; Karaguni Ionna-Maria; Nowak Thorsten; Bate Michael; Kuhlmann Jürgen; Müller Oliver; Waldmann Herbert
Identification of mono- and bisubstrate inhibitors of protein farnesyltransferase and inducers of apoptosis from a pepticinnamin E library.
Bioorganic & medicinal chemistry 2003;11(12):2617-26.
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2002: Thutewohl Michael; Kissau Lars; Popkirova Boriana; Karaguni Ionna-Maria; Nowak Thorsten; Bate Michael; Kuhlmann Jürgen; Müller Oliver; Waldmann Herbert
Solid-phase synthesis and biological evaluation of a pepticinnamin E library.
Angewandte Chemie (International ed. in English) 2002;41(19):3616-20; 3516.
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2002: Kuhlmann Jürgen; Tebbe Andreas; Völkert Martin; Wagner Melanie; Uwai Koji; Waldmann Herbert
Photoactivatable synthetic Ras proteins: "baits" for the identification of plasma-membrane-bound binding partners of Ras.
Angewandte Chemie (International ed. in English) 2002;41(14):2546-50.
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2001: Renault L; Kuhlmann J; Henkel A; Wittinghofer A
Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1).
Cell 2001;105(2):245-55.
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2001: Kuhn K; Owen D J; Bader B; Wittinghofer A; Kuhlmann J; Waldmann H
Synthesis of functional Ras lipoproteins and fluorescent derivatives.
Journal of the American Chemical Society 2001;123(6):1023-35.
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2000: Kadereit D; Kuhlmann J; Waldmann H
Linking the fields--the interplay of organic synthesis, biophysical chemistry, and cell biology in the chemical biology of protein lipidation.
Chembiochem : a European journal of chemical biology 2000;1(3):144-69.
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2000: Villa Braslavsky C I; Nowak C; Görlich D; Wittinghofer A; Kuhlmann J
Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta.
Biochemistry 2000;39(38):11629-39.
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1999: Vetter I R; Nowak C; Nishimoto T; Kuhlmann J; Wittinghofer A
Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.
Nature 1999;398(6722):39-46.
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1998: Lenzen C; Cool R H; Prinz H; Kuhlmann J; Wittinghofer A
Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm.
Biochemistry 1998;37(20):7420-30.
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1997: Kuhlmann J; Macara I; Wittinghofer A
Dynamic and equilibrium studies on the interaction of Ran with its effector, RanBP1.
Biochemistry 1997;36(40):12027-35.
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