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Michaela Kuhn

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Chemicals & Drugs

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Reverse Transcriptase Polymerase Chain Reaction

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Stefan Frantz; Birgit Gaβner; Franz Hofmann; Michael Klaiber; Marco Abeβer; Hideo A Baba; Barbara Bayer; Robert Feil; Heike Oberwinkler; Kai Schuh; Katharina Völker; Michaela Kuhn
Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I.
Michaela Kuhn
Endothelial actions of atrial and B-type natriuretic peptides.
Wen Chen; Birgit Gassner; Sebastian Börner; Viacheslav O Nikolaev; Nicolas Schlegel; Nadine Steinbronn; Ruth Strasser; Jens Waschke; Michaela Kuhn
Atrial natriuretic peptide enhances microvascular albumin permeability by the caveolae-mediated transcellular pathway.

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All Publications

2013: Stefan Frantz; Birgit Gaβner; Franz Hofmann; Michael Klaiber; Marco Abeβer; Hideo A Baba; Barbara Bayer; Robert Feil; Heike Oberwinkler; Kai Schuh; Katharina Völker; Michaela Kuhn
Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I.
European heart journal 2013;34(16):1233-44.
2012: Michaela Kuhn
Endothelial actions of atrial and B-type natriuretic peptides.
British journal of pharmacology 2012;166(2):522-31.
2012: Wen Chen; Birgit Gassner; Sebastian Börner; Viacheslav O Nikolaev; Nicolas Schlegel; Nadine Steinbronn; Ruth Strasser; Jens Waschke; Michaela Kuhn
Atrial natriuretic peptide enhances microvascular albumin permeability by the caveolae-mediated transcellular pathway.
Cardiovascular research 2012;93(1):141-51.
2010: Dieter Müller; Mirjam Hildebrand; Jörn Lübberstedt; Michaela Kuhn; Ralf Middendorff
The membrane receptors guanylyl cyclase-A and -B undergo distinctive changes in post-translational modification during brain development.
Journal of neurochemistry 2010;115(4):1024-34.
2010: Michael Klaiber; Martin Kruse; Katharina Völker; Juliane Schröter; Robert Feil; Marc Freichel; Andrea Gerling; Susanne Feil; Alexander Dietrich; Juan Eduardo Camacho Londoño; Hideo A Baba; Joel Abramowitz; Lutz Birnbaumer; Josef M Penninger; Olaf Pongs; Michaela Kuhn
Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2.
Basic research in cardiology 2010;105(5):583-95.
2010: Juliane Schröter; René P Zahedi; Michael Hartmann; Birgit Gassner; Alexandra Gazinski; Jens Waschke; Albert Sickmann; Michaela Kuhn
Homologous desensitization of guanylyl cyclase A, the receptor for atrial natriuretic peptide, is associated with a complex phosphorylation pattern.
The FEBS journal 2010;277(11):2440-53.
2009: Michaela Kuhn; Katharina Völker; Kristine Schwarz; Javier Carbajo-Lozoya; Ulrich Flögel; Christoph Jacoby; Jörg Stypmann; Martin van Eickels; Stepan Gambaryan; Michael Hartmann; Matthias Werner; Thomas Wieland; Jürgen Schrader; Hideo A Baba
The natriuretic peptide/guanylyl cyclase--a system functions as a stress-responsive regulator of angiogenesis in mice.
The Journal of clinical investigation 2009;119(7):2019-30.
2009: Karim Sabrane; Markus-N Kruse; Alexandra Gazinski; Michaela Kuhn
Chronic endothelium-dependent regulation of arterial blood pressure by atrial natriuretic peptide: role of nitric oxide and endothelin-1.
Endocrinology 2009;150(5):2382-7.
2008: Michael Hartmann; Boris Skryabin; Thomas Müller; Alexandra Gazinski; Juliane Schröter; Birgit Gassner; Viacheslav O Nikolaev; Moritz Bünemann; Michaela Kuhn
Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signaling.
The Journal of biological chemistry 2008;283(42):28313-20.
2008: Barbara Schreier; Sebastian Börner; Katharina Völker; Stepan Gambaryan; Stephan C Schäfer; Peter Kuhlencordt; Birgit Gassner; Michaela Kuhn
The heart communicates with the endothelium through the guanylyl cyclase-A receptor: acute handling of intravascular volume in response to volume expansion.
Endocrinology 2008;149(8):4193-9.
2007: Ana Kilić; Alexander Bubikat; Birgit Gassner; Hideo A Baba; Michaela Kuhn
Local actions of atrial natriuretic peptide counteract angiotensin II stimulated cardiac remodeling.
Endocrinology 2007;148(9):4162-9.
2007: Sevdalina Yurukova; Ana Kilić; Katharina Völker; Kirsten Leineweber; Nataliya Dybkova; Lars S Maier; Otto-Erich Brodde; Michaela Kuhn
CaMKII-mediated increased lusitropic responses to beta-adrenoreceptor stimulation in ANP-receptor deficient mice.
Cardiovascular research 2007;73(4):678-88.
2006: Katrin Kliche; Michaela Kuhn; Uta Hillebrand; Yvonne Ludwig; Christian Stock; Hans Oberleithner
Direct aldosterone action on mouse cardiomyocytes detected with atomic force microscopy.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2006;18(4-5):265-74.
2005: Ana Kilic; Ana Velic; Leon J De Windt; Larissa Fabritz; Melanie Voss; Danuta Mitko; Melanie Zwiener; Hideo A Baba; Martin van Eickels; Eberhard Schlatter; Michaela Kuhn
Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice.
Circulation 2005;112(15):2307-17.
2005: Aleksandra Sindić; Ana Velic; Candan Başoglu; Jochen R Hirsch; Bayram Edemir; Michaela Kuhn; Eberhard Schlatter
Uroguanylin and guanylin regulate transport of mouse cortical collecting duct independent of guanylate cyclase C.
Kidney international 2005;68(3):1008-17.
2005: Alexander Bubikat; Leon J De Windt; Bernd Zetsche; Larissa Fabritz; Heidrun Sickler; Dominik Eckardt; Axel Gödecke; Hideo A Baba; Michaela Kuhn
Local atrial natriuretic peptide signaling prevents hypertensive cardiac hypertrophy in endothelial nitric-oxide synthase-deficient mice.
The Journal of biological chemistry 2005;280(22):21594-9.
2005: Karim Sabrane; Markus N Kruse; Larissa Fabritz; Bernd Zetsche; Danuta Mitko; Boris Skryabin; Melanie Zwiener; Hideo A Baba; Masashi Yanagisawa; Michaela Kuhn
Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide.
The Journal of clinical investigation 2005;115(6):1666-74.
2005: Michaela Kuhn
Cardiac and intestinal natriuretic peptides: insights from genetically modified mice.
Peptides 2005;26(6):1078-85.
2004: Michaela Kuhn; Melanie Voss; Danuta Mitko; Jörg Stypmann; Christof Schmid; Naomasa Kawaguchi; Florian Grabellus; Hideo A Baba
Left ventricular assist device support reverses altered cardiac expression and function of natriuretic peptides and receptors in end-stage heart failure.
Cardiovascular research 2004;64(2):308-14.
2004: Boris Skryabin; Rita Holtwick; Larissa Fabritz; Markus N Kruse; Ilka Veltrup; Jörg Stypmann; Paulus Kirchhof; Karim Sabrane; Alexander Bubikat; Melanie Voss; Michaela Kuhn
Hypervolemic hypertension in mice with systemic inactivation of the (floxed) guanylyl cyclase-A gene by alphaMHC-Cre-mediated recombination.
Genesis (New York, N.Y. : 2000) 2004;39(4):288-98.
2004: Martin Steinmetz; Regine Potthast; Karim Sabrane; Michaela Kuhn
Diverging vasorelaxing effects of C-type natriuretic peptide in renal resistance arteries and aortas of GC-A-deficient mice.
Regulatory peptides 2004;119(1-2):31-7.
2004: Paulus Kirchhof; Larissa Fabritz; Ana Kilić; Frank Begrow; Günter Breithardt; Michaela Kuhn
Ventricular arrhythmias, increased cardiac calmodulin kinase II expression, and altered repolarization kinetics in ANP receptor deficient mice.
Journal of molecular and cellular cardiology 2004;36(5):691-700.
2004: Michaela Kuhn; Chi Kin Domingos Ng; Yueh-Hsing Su; Ana Kilić; Danuta Mitko; Nga Bien-Ly; László G Kömüves; Ruey-Bing Yang
Identification of an orphan guanylate cyclase receptor selectively expressed in mouse testis.
The Biochemical journal 2004;379(Pt 2):385-93.
2004: Michaela Kuhn
Molecular physiology of natriuretic peptide signalling.
Basic research in cardiology 2004;99(2):76-82.
2003: Kai C Wollert; Sevdalina Yurukova; Ana Kilic; Frank Begrow; Beate Fiedler; Stepan Gambaryan; Ulrich Walter; Suzanne M Lohmann; Michaela Kuhn
Increased effects of C-type natriuretic peptide on contractility and calcium regulation in murine hearts overexpressing cyclic GMP-dependent protein kinase I.
British journal of pharmacology 2003;140(7):1227-36.
2003: Michaela Kuhn
Structure, regulation, and function of mammalian membrane guanylyl cyclase receptors, with a focus on guanylyl cyclase-A.
Circulation research 2003;93(8):700-9.
2003: Karim Sabrane; Stepan Gambaryan; Ralf P Brandes; Rita Holtwick; Melanie Voss; Michaela Kuhn
Increased sensitivity to endothelial nitric oxide (NO) contributes to arterial normotension in mice with vascular smooth muscle-selective deletion of the atrial natriuretic peptide (ANP) receptor.
The Journal of biological chemistry 2003;278(20):17963-8.
2003: Rita Holtwick; Martin van Eickels; Boris Skryabin; Hideo A Baba; Alexander Bubikat; Frank Begrow; Michael D Schneider; David L Garbers; Michaela Kuhn
Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A.
The Journal of clinical investigation 2003;111(9):1399-407.
2002: Rita Holtwick; Hideo A Baba; Elisabeth Ehler; Dorothée Risse; Melanie Vobeta; Joseph Gehrmann; Melanie Pierkes; Michaela Kuhn
Left but not right cardiac hypertrophy in atrial natriuretic peptide receptor-deficient mice is prevented by angiotensin type 1 receptor antagonist losartan.
Journal of cardiovascular pharmacology 2002;40(5):725-34.
2002: Aleksandra Sindiće; Candan Başoglu; Ayhan Cerçi; Jochen R Hirsch; Regine Potthast; Michaela Kuhn; Yashoda Ghanekar; Sandhya S Visweswariah; Eberhard Schlatter
Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells.
The Journal of biological chemistry 2002;277(20):17758-64.
2002: Rita Holtwick; Michael Gotthardt; Boris Skryabin; Martin Steinmetz; Regine Potthast; Bernd Zetsche; Robert E Hammer; Joachim Herz; Michaela Kuhn
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):7142-7.
2002: Michaela Kuhn; Rita Holtwick; Hideo A Baba; J C Perriard; Wilhelm Schmitz; Elisabeth Ehler
Progressive cardiac hypertrophy and dysfunction in atrial natriuretic peptide receptor (GC-A) deficient mice.
Heart (British Cardiac Society) 2002;87(4):368-74.
2002: Melanie Pierkes; Stepan Gambaryan; Peter Bokník; Suzanne M Lohmann; Wilhelm Schmitz; Regine Potthast; Rita Holtwick; Michaela Kuhn
Increased effects of C-type natriuretic peptide on cardiac ventricular contractility and relaxation in guanylyl cyclase A-deficient mice.
Cardiovascular research 2002;53(4):852-61.
2001: Regine Potthast; Elisabeth Ehler; L A Scheving; Aleksandra Sindic; Eberhard Schlatter; Michaela Kuhn
High salt intake increases uroguanylin expression in mouse kidney.
Endocrinology 2001;142(7):3087-97.
1999: Matthias Reinhard; J Zumbrunn; D Jaquemar; Michaela Kuhn; Ulrich Walter; Beat Trueb
An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment.
The Journal of biological chemistry 1999;274(19):13410-8.
1998: M John; Bertram Wiedenmann; M Kruhøffer; Knut Adermann; I Ankorina-Stark; Eberhard Schlatter; Gudrun Ahnert-Hilger; Wolf-Georg Forssmann; Michaela Kuhn
Guanylin stimulates regulated secretion from human neuroendocrine pancreatic cells.
Gastroenterology 1998;114(4):791-7.
1997: Jochen R Hirsch; R Cermak; Wolf-Georg Forssmann; Robert Kleta; M Kruhøffer; Michaela Kuhn; James A Schafer; D Sun; Eberhard Schlatter
Effects of sodium nitroprusside in the rat cortical collecting duct are independent of the NO pathway.
Kidney international 1997;51(2):473-6.