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Keisuke Kuida

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Masato Koike; Masahiro Shibata; Masao Tadakoshi; Kunihito Gotoh; Masaaki Komatsu; Satoshi Waguri; Nobutaka Kawahara; Keisuke Kuida; Shigekazu Nagata; Eiki Kominami; Keiji Tanaka; Yasuo Uchiyama
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury.
Woods Wannamaker; Robert Davies; Mark Namchuk; John Pollard; Pamella Ford; George Ku; Caroline Decker; Paul S Charifson; peter weber; ursula germann; Keisuke Kuida; John C R Randle
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18.
Jun Arai; Naomichi Katai; Keisuke Kuida; Takanobu Kikuchi; Nagahisa Yoshimura
Decreased retinal neuronal cell death in caspase-1 knockout mice.

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All Publications

2008: Masato Koike; Masahiro Shibata; Masao Tadakoshi; Kunihito Gotoh; Masaaki Komatsu; Satoshi Waguri; Nobutaka Kawahara; Keisuke Kuida; Shigekazu Nagata; Eiki Kominami; Keiji Tanaka; Yasuo Uchiyama
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury.
The American journal of pathology 2008;172(2):454-69.
2007: Woods Wannamaker; Robert Davies; Mark Namchuk; John Pollard; Pamella Ford; George Ku; Caroline Decker; Paul S Charifson; peter weber; ursula germann; Keisuke Kuida; John C R Randle
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18.
The Journal of pharmacology and experimental therapeutics 2007;321(2):509-16.
2006: Jun Arai; Naomichi Katai; Keisuke Kuida; Takanobu Kikuchi; Nagahisa Yoshimura
Decreased retinal neuronal cell death in caspase-1 knockout mice.
Japanese journal of ophthalmology 2006;50(5):417-25.
2006: Katsuya Kominami; Chiyo Takagi; Tomoko Kurata; Atsushi Kitayama; Masami Nozaki; Tatsuya Sawasaki; Keisuke Kuida; Yaeta Endo; Noboru Manabe; Naoto Ueno; Kazuhiro Sakamaki
The initiator caspase, caspase-10beta, and the BH-3-only molecule, Bid, demonstrate evolutionary conservation in Xenopus of their pro-apoptotic activities in the extrinsic and intrinsic pathways.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(7):701-17.
2006: Dario S Zamboni; Koichi Kobayashi; Tiana Kohlsdorf; Yasunori Ogura; E Michelle Long; Russell E Vance; Keisuke Kuida; Sanjeev Mariathasan; Xiaodong Huang; Richard A Flavell; William F Dietrich; Craig R Roy
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.
Nature immunology 2006;7(3):318-25.
2006: Saquib A Lakhani; Ali Masud; Keisuke Kuida; George A Porter; Carmen J Booth; Wajahat Z Mehal; Irteza Bin Inayat; Richard A Flavell
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.
Science (New York, N.Y.) 2006;311(5762):847-51.
2006: Zhili Shao; Kausik Bhattacharya; Eileen Hsich; Larry Park; Brian Walters; ursula germann; Yow-Ming Wang; John Kyriakis; Ramon Mohanlal; Keisuke Kuida; Mark Namchuk; Francesco Salituro; Yung-mae Yao; Wei-min Hou; Xin Chen; Mark Aronovitz; Philip Tsichlis; Susmita Bhattacharya; Thomas Force; Heiko Kilter
c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo.
Circulation research 2006;98(1):111-8.
2005: Masatoshi Ohgushi; Shunsuke Kuroki; Hiroshi Fukamachi; Lorraine A O'Reilly; Keisuke Kuida; Andreas Strasser; Shin Yonehara
Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells.
Molecular and cellular biology 2005;25(22):10017-28.
2004: Koji Oishi; Sachiko Kamakura; Yuko Isazawa; Takeshi Yoshimatsu; Keisuke Kuida; Masato Nakafuku; Norihisa Masuyama; Yukiko Gotoh
Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis.
Developmental biology 2004;276(1):172-84.
2004: Keisuke Kuida; Diane Boucher
Functions of MAP kinases: insights from gene-targeting studies.
Journal of biochemistry 2004;135(6):653-6.
2004: Thomas Force; Keisuke Kuida; Mark Namchuk; Keykavous Parang; John M Kyriakis
Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease.
Circulation 2004;109(10):1196-205.
2004: hiroshi takuma; Takami Tomiyama; Keisuke Kuida; Hiroshi Mori
Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo.
Journal of neuropathology and experimental neurology 2004;63(3):255-61.
2004: Naotoshi Tsuji; Hiroko Tsutsui; Ekihiro Seki; Keisuke Kuida; Haruki Okamura; Kenji Nakanishi; Richard A Flavell
Roles of caspase-1 in Listeria infection in mice.
International immunology 2004;16(2):335-43.
2003: Yao Yao; Wei Li; Junwei Wu; ursula germann; Michael S S Su; Keisuke Kuida; Diane Boucher
Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12759-64.
2003: Atsushi Jimbo; Eriko Fujita; Yoriko Kouroku; J Ohnishi; Naohiro Inohara; Keisuke Kuida; Kazuhiro Sakamaki; Shin Yonehara; Takashi Momoi
ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.
Experimental cell research 2003;283(2):156-66.
2002: Dean A Le; Yongqin Wu; Zhihong Huang; Kohji Matsushita; Nikolaus Plesnila; Jean C Augustinack; Bradley T Hyman; Junying Yuan; Keisuke Kuida; Richard A Flavell; Michael A Moskowitz
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):15188-93.
2002: Vanessa S Marsden; Liam O'Connor; Lorraine A O'Reilly; John Silke; Donald Metcalf; Paul G Ekert; David C S Huang; Francesco Cecconi; Keisuke Kuida; Kevin J Tomaselli; Sophie Roy; Don W Nicholson; David L Vaux; Philippe Bouillet; Jerry M Adams; Andreas Strasser
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome.
Nature 2002;419(6907):634-7.
2002: Lorraine A O'Reilly; Paul G Ekert; N Harvey; Vanessa S Marsden; L Cullen; David L Vaux; G Hacker; C Magnusson; Miha Pakusch; Francesco Cecconi; Keisuke Kuida; Andreas Strasser; David C S Huang; Sharad Kumar
Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9.
Cell death and differentiation 2002;9(8):832-41.
2002: christopher regan; Wei Li; Diane Boucher; Stephen Spatz; Michael S S Su; Keisuke Kuida
Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9248-53.
2002: Yoriko Kouroku; Eriko Fujita; Atsushi Jimbo; Tateki Kikuchi; Takanori Yamagata; Mariko Y Momoi; Eiki Kominami; Keisuke Kuida; Kazuhiro Sakamaki; Shin Yonehara; Takashi Momoi
Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation.
Human molecular genetics 2002;11(13):1505-15.
2001: Eriko Fujita; J Egashira; Koko Urase; Keisuke Kuida; Takashi Momoi
Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo.
Cell death and differentiation 2001;8(4):335-44.
2001: Katsumasa Takahashi; K Kamiya; Koko Urase; M Suga; T Takizawa; Hiroshi Mori; Y Yoshikawa; K Ichimura; Keisuke Kuida; T Momoi
Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss.
Brain research 2001;894(2):359-67.
2001: Ekihiro Seki; H Tsutsui; H Nakano; Naotoshi Tsuji; K Hoshino; O Adachi; K Adachi; S Futatsugi; Keisuke Kuida; Osamu Takeuchi; H Okamura; J Fujimoto; S Akira; K Nakanishi
Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2651-7.
2001: AU Zaidi; C D'Sa-Eipper; J Brenner; Keisuke Kuida; TS Zheng; Richard A Flavell; Pasko Rakic; Kevin A Roth
Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(1):169-75.
2001: C D'Sa-Eipper; Jeffrey R Leonard; G Putcha; TS Zheng; Richard A Flavell; Pasko Rakic; Keisuke Kuida; Kevin A Roth
DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3.
Development (Cambridge, England) 2001;128(1):137-46.
2000: Tongzhang Zheng; Stéphane Hunot; Keisuke Kuida; T Momoi; A Srinivasan; D W Nicholson; Y Lazebnik; Richard A Flavell
Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation.
Nature medicine 2000;6(11):1241-7.
2000: Eriko Fujita; Koko Urase; J Egashira; Y Miho; K Isahara; Yasuo Uchiyama; Atsushi Isoai; Hiromichi Kumagai; Keisuke Kuida; N Motoyama; Takashi Momoi
Detection of caspase-9 activation in the cell death of the Bcl-x-deficient mouse embryo nervous system by cleavage sites-directed antisera.
Brain research. Developmental brain research 2000;122(2):135-47.
2000: T Hatai; Atsushi Matsuzawa; Seiji Inoshita; Y Mochida; Takayuki Kuroda; Kazuhiro Sakamaki; Keisuke Kuida; Shin Yonehara; Hidenori Ichijo; Kiyoshi Takeda
Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation.
The Journal of biological chemistry 2000;275(34):26576-81.
2000: J Endo; Noriko Toyama-Sorimachi; Choji Taya; S Kuramochi-Miyagawa; K Nagata; Keisuke Kuida; T Takashi; H Yonekawa; Y Yoshizawa; N Miyasaka; Hajime Karasuyama
Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes.
FEBS letters 2000;468(2-3):234-8.
2000: Kevin A Roth; Chia-Yi Kuan; Tarik F Haydar; C D'Sa-Eipper; Kenneth Shindler; TS Zheng; Keisuke Kuida; Richard A Flavell; Pasko Rakic
Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):466-71.
1999: T S Zheng; Stéphane Hunot; Keisuke Kuida; R A Flavell
Caspase knockouts: matters of life and death.
Cell death and differentiation 1999;6(11):1043-53.
1999: Elizabeth Eynon; Ferenc Livak; Keisuke Kuida; David G Schatz; Richard A Flavell
Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1448-59.
1998: K Tsuganezawa; Nobutaka Kiyokawa; Y Matsuo; Fujiko Kitamura; Noriko Toyama-Sorimachi; Keisuke Kuida; J Fujimoto; Hajime Karasuyama
Flow cytometric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human pre-B-cell receptor.
Blood 1998;92(11):4317-24.
1998: Keisuke Kuida; Tarik F Haydar; Chia-Yi Kuan; Y Gu; Choji Taya; H Karasuyama; Michael S S Su; Pasko Rakic; RA Flavell
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9.
Cell 1998;94(3):325-37.
1997: Akira Nakagawara; Yohko Nakamura; H Ikeda; T Hiwasa; Keisuke Kuida; Michael S S Su; H Zhao; A Cnaan; Shigeru Sakiyama
High levels of expression and nuclear localization of interleukin-1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas.
Cancer research 1997;57(20):4578-84.
1997: H Ikeda; Yohko Nakamura; T Hiwasa; Shigeru Sakiyama; Keisuke Kuida; Michael S S Su; Akira Nakagawara
Interleukin-1 beta converting enzyme (ICE) is preferentially expressed in neuroblastomas with favourable prognosis.
European journal of cancer (Oxford, England : 1990) 1997;33(12):2081-3.
1997: Keisuke Kuida
[MHC class II restricted antigen presentation].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(14 Suppl):2376-9.
1997: S Kuramochi; T Moriguchi; Keisuke Kuida; J Endo; K Semba; E Nishida; Hajime Karasuyama
LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes.
The Journal of biological chemistry 1997;272(36):22679-84.
1997: Y Eugene Chin; M Kitagawa; Keisuke Kuida; Richard A Flavell; Xin-Yuan Fu
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis.
Molecular and cellular biology 1997;17(9):5328-37.
1997: Keisuke Kuida
[Caspase family proteases and apoptosis].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(10 Suppl):1630-6.
1997: Hajime Karasuyama; T Nakamura; K Nagata; T Kuramochi; Fujiko Kitamura; Keisuke Kuida
The roles of preB cell receptor in early B cell development and its signal transduction.
Immunology and cell biology 1997;75(2):209-16.
1997: Giamila Fantuzzi; George Ku; MW Harding; David J Livingston; J D Sipe; Keisuke Kuida; RA Flavell; Charles A Dinarello
Response to local inflammation of IL-1 beta-converting enzyme- deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1818-24.
1997: Michael Amling; Lynn Neff; Sakae Tanaka; D Inoue; Keisuke Kuida; E Weir; William M Philbrick; Arthur E Broadus; Roland Baron
Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development.
The Journal of cell biology 1997;136(1):205-13.
1997: Y Gu; Keisuke Kuida; H Tsutsui; George Ku; K Hsiao; MA Fleming; N Hayashi; K Higashino; H Okamura; K Nakanishi; M Kurimoto; T Tanimoto; RA Flavell; V Sato; MW Harding; David J Livingston; Michael S S Su
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme.
Science (New York, N.Y.) 1997;275(5297):206-9.
1996: Keisuke Kuida; T S Zheng; S Na; Chia-Yi Kuan; D Yang; H Karasuyama; Pasko Rakic; Richard A Flavell
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice.
Nature 1996;384(6607):368-72.
1996: Elizabeth Eynon; Keisuke Kuida; Richard A Flavell
Disruption of cytokine signaling in lymphoid development: unique contributions of the common cytokine gamma chain and the Jak3 kinase.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(9):677-84.
1995: H Suwa; Toshiyuki Tanaka; Fujiko Kitamura; T Shiohara; Keisuke Kuida; M Miyasaka
Dysregulated expression of the IL-2 receptor beta-chain abrogates development of NK cells and Thy-1+ dendritic epidermal cells in transgenic mice.
International immunology 1995;7(9):1441-9.
1995: Keisuke Kuida; J A Lippke; George Ku; MW Harding; David J Livingston; Michael S S Su; Richard A Flavell
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.
Science (New York, N.Y.) 1995;267(5206):2000-3.
1993: Toshiyuki Tanaka; Fujiko Kitamura; Y Nagasaka; Keisuke Kuida; H Suwa; M Miyasaka
Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice.
The Journal of experimental medicine 1993;178(3):1103-7.
1993: T Tamatani; Fujiko Kitamura; Keisuke Kuida; M Shirao; M Mochizuki; M Suematsu; G W Schmid-Schönbein; K Watanabe; S Tsurufuji; M Miyasaka
Characterization of rat LECAM-1 (L-selectin) by the use of monoclonal antibodies and evidence for the presence of soluble LECAM-1 in rat sera.
European journal of immunology 1993;23(9):2181-8.
1993: Toshiyuki Tanaka; Y Nagasaka; Fujiko Kitamura; Keisuke Kuida; H Suwa; M Miyasaka
The role of the interleukin-2 (IL-2)/IL-2 receptor pathway in MRL/lpr lymphadenopathy: the expanded CD4-8- T cell subset completely lacks functional IL-2 receptors.
European journal of immunology 1993;23(6):1378-80.
1993: T Tamatani; Keisuke Kuida; T Watanabe; S Koike; M Miyasaka
Molecular mechanisms underlying lymphocyte recirculation. III. Characterization of the LECAM-1 (L-selectin)-dependent adhesion pathway in rats.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(5):1735-45.
1992: Keisuke Kuida; Toshiyuki Tanaka; Fujiko Kitamura; Noriko Toyama-Sorimachi; M Miyasaka
Reconstitution of the intermediate-affinity interleukin-2 receptor by cell fusion.
International immunology 1992;4(10):1123-8.