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Oscar Kuipers

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Oligonucleotide Array Sequence Analysis

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Co-Publications
Name
49
Kok, Jan
40
DE VOS, WILLEM
24
Buist, Girbe
22
van Hijum, Sacha
21
Siezen, RJ
20
Hamoen, Leendert
16
Veening, Jan-Willem
14
Smits, Wiep Klaas
13
de Jong, Anne
13
Bron, Sierd
11
de Kruijff, Ben
10
Breukink, Eefjan
10
Driessen, Arnold
10
Zomer, Aldert
9
Kleerebezem, Michiel

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Publications

TOP 3
van Hijum Sacha A F T; Medema Marnix H; Kuipers Oscar P
Mechanisms and evolution of control logic in prokaryotic transcriptional regulation.
Lubelski Jacek; Khusainov Rustem; Kuipers Oscar P
Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin.
Kovács Akos T; Smits Wiep Klaas; Mironczuk Aleksandra M; Kuipers Oscar P
Ubiquitous late competence genes in Bacillus species indicate the presence of functional DNA uptake machineries.

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All Publications

2009: van Hijum Sacha A F T; Medema Marnix H; Kuipers Oscar P
Mechanisms and evolution of control logic in prokaryotic transcriptional regulation.
Microbiology and molecular biology reviews : MMBR 2009;73(3):481-509, Table of Contents.
2009: Lubelski Jacek; Khusainov Rustem; Kuipers Oscar P
Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin.
The Journal of biological chemistry 2009;284(38):25962-72.
2009: Kovács Akos T; Smits Wiep Klaas; Mironczuk Aleksandra M; Kuipers Oscar P
Ubiquitous late competence genes in Bacillus species indicate the presence of functional DNA uptake machineries.
Environmental microbiology 2009;11(8):1911-22.
2009: Ridder Anja N J A; de Jong Esther J; Jongbloed Jan D H; Kuipers Oscar P
Subcellular localization of TatAd of Bacillus subtilis depends on the presence of TatCd or TatCy.
Journal of bacteriology 2009;191(13):4410-8.
2009: Eijlander Robyn T; Kolbusz Magdalena A; Berendsen Erwin M; Kuipers Oscar P
Effects of altered TatC proteins on protein secretion efficiency via the twin-arginine translocation pathway of Bacillus subtilis.
Microbiology (Reading, England) 2009;155(Pt 6):1776-85.
2009: Hendriksen Wouter T; Bootsma Hester J; van Diepen Angela; Estevão Silvia; Kuipers Oscar P; de Groot Ronald; Hermans Peter W M
Strain-specific impact of PsaR of Streptococcus pneumoniae on global gene expression and virulence.
Microbiology (Reading, England) 2009;155(Pt 5):1569-79.
2009: Chillappagari Shashi; Miethke Marcus; Trip Hein; Kuipers Oscar P; Marahiel Mohamed A
Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis.
Journal of bacteriology 2009;191(7):2362-70.
2009: Blom Evert-Jan; Roerdink Jos B T M; Kuipers Oscar P; van Hijum Sacha A F T
MOTIFATOR: detection and characterization of regulatory motifs using prokaryote transcriptome data.
Bioinformatics (Oxford, England) 2009;25(4):550-1.
2009: Castro Rute; Neves Ana R; Fonseca Luís L; Pool Wietske A; Kok Jan; Kuipers Oscar P; Santos Helena
Characterization of the individual glucose uptake systems of Lactococcus lactis: mannose-PTS, cellobiose-PTS and the novel GlcU permease.
Molecular microbiology 2009;71(3):795-806.
2009: Brouwer Rutger W W; van Hijum Sacha A F T; Kuipers Oscar P
MINOMICS: visualizing prokaryote transcriptomics and proteomics data in a genomic context.
Bioinformatics (Oxford, England) 2009;25(1):139-40.
2009: Grande Burgos María J; Kovács Akos T; Mironczuk Aleksandra M; Abriouel Hikmate; Gálvez Antonio; Kuipers Oscar P
Response of Bacillus cereus ATCC 14579 to challenges with sublethal concentrations of enterocin AS-48.
BMC microbiology 2009;9():227.
2008: Zaidi Arsalan Haseeb; Bakkes Patrick J; Lubelski Jacek; Agustiandari Herfita; Kuipers Oscar P; Driessen Arnold J M
The ABC-type multidrug resistance transporter LmrCD is responsible for an extrusion-based mechanism of bile acid resistance in Lactococcus lactis.
Journal of bacteriology 2008;190(22):7357-66.
2008: Brouwer Rutger W W; Kuipers Oscar P; van Hijum Sacha A F T
The relative value of operon predictions.
Briefings in bioinformatics 2008;9(5):367-75.
2008: Kuipers Oscar P; Poolman Bert; Hugenholtz Jeroen
9th International Symposium on Lactic Acid Bacteria.
Applied and environmental microbiology 2008;74(15):4589.
2008: Stevens Marc J A; Wiersma Anne; de Vos Willem M; Kuipers Oscar P; Smid Eddy J; Molenaar Douwe; Kleerebezem Michiel
Improvement of Lactobacillus plantarum aerobic growth as directed by comprehensive transcriptome analysis.
Applied and environmental microbiology 2008;74(15):4776-8.
2008: Lubelski Jacek; Overkamp Wout; Kluskens Leon D; Moll Gert N; Kuipers Oscar P
Influence of shifting positions of Ser, Thr, and Cys residues in prenisin on the efficiency of modification reactions and on the antimicrobial activities of the modified prepeptides.
Applied and environmental microbiology 2008;74(15):4680-5.
2008: Steen Anton; Buist Girbe; Kramer Naomi E; Jalving Ruud; Benus Germaine F J D; Venema Gerard; Kuipers Oscar P; Kok Jan
Reduced lysis upon growth of Lactococcus lactis on galactose is a consequence of decreased binding of the autolysin AcmA.
Applied and environmental microbiology 2008;74(15):4671-9.
2008: Larsen Rasmus; van Hijum Sacha A F T; Martinussen Jan; Kuipers Oscar P; Kok Jan
Transcriptome analysis of the Lactococcus lactis ArgR and AhrC regulons.
Applied and environmental microbiology 2008;74(15):4768-71.
2008: Kloosterman Tomas G; Witwicki Robert M; van der Kooi-Pol Magdalena M; Bijlsma Jetta J E; Kuipers Oscar P
Opposite effects of Mn2+ and Zn2+ on PsaR-mediated expression of the virulence genes pcpA, prtA, and psaBCA of Streptococcus pneumoniae.
Journal of bacteriology 2008;190(15):5382-93.
2008: Kramer Naomi E; Hasper Hester E; van den Bogaard Patrick T C; Morath Siegfried; de Kruijff Ben; Hartung Thomas; Smid Eddy J; Breukink Eefjan; Kok Jan; Kuipers Oscar P
Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis.
Microbiology (Reading, England) 2008;154(Pt 6):1755-62.
2008: Buist Girbe; Steen Anton; Kok Jan; Kuipers Oscar P
LysM, a widely distributed protein motif for binding to (peptido)glycans.
Molecular microbiology 2008;68(4):838-47.
2008: Veening Jan-Willem; Stewart Eric J; Berngruber Thomas W; Taddei François; Kuipers Oscar P; Hamoen Leendert W
Bet-hedging and epigenetic inheritance in bacterial cell development.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4393-8.
2008: Hendriksen Wouter T; Kloosterman Tomas G; Bootsma Hester J; Estevão Silvia; de Groot Ronald; Kuipers Oscar P; Hermans Peter W M
Site-specific contributions of glutamine-dependent regulator GlnR and GlnR-regulated genes to virulence of Streptococcus pneumoniae.
Infection and immunity 2008;76(3):1230-8.
2008: Barnett James P; Eijlander Robyn T; Kuipers Oscar P; Robinson Colin
A minimal Tat system from a gram-positive organism: a bifunctional TatA subunit participates in discrete TatAC and TatA complexes.
The Journal of biological chemistry 2008;283(5):2534-42.
2008: Widdick David A; Eijlander Robyn T; van Dijl Jan Maarten; Kuipers Oscar P; Palmer Tracy
A facile reporter system for the experimental identification of twin-arginine translocation (Tat) signal peptides from all kingdoms of life.
Journal of molecular biology 2008;375(3):595-603.
2008: Mendel Sharon; McCarthy Andrew; Barnett James P; Eijlander Robyn T; Nenninger Anja; Kuipers Oscar P; Robinson Colin
The Escherichia coli TatABC system and a Bacillus subtilis TatAC-type system recognise three distinct targeting determinants in twin-arginine signal peptides.
Journal of molecular biology 2008;375(3):661-72.
2008: Hendriksen Wouter T; Bootsma Hester J; Estevão Silvia; Hoogenboezem Theo; de Jong Anne; de Groot Ronald; Kuipers Oscar P; Hermans Peter W M
CodY of Streptococcus pneumoniae: link between nutritional gene regulation and colonization.
Journal of bacteriology 2008;190(2):590-601.
2008: Agustiandari Herfita; Lubelski Jacek; van den Berg van Saparoea H Bart; Kuipers Oscar P; Driessen Arnold J M
LmrR is a transcriptional repressor of expression of the multidrug ABC transporter LmrCD in Lactococcus lactis.
Journal of bacteriology 2008;190(2):759-63.
2008: Blom Evert-Jan; van Hijum Sacha A F T; Hofstede Klaas J; Silvis Remko; Roerdink Jos B T M; Kuipers Oscar P
DISCLOSE : DISsection of CLusters Obtained by SEries of transcriptome data using functional annotations and putative transcription factor binding sites.
BMC bioinformatics 2008;9():535.
2008: Blom Evert Jan; Breitling Rainer; Hofstede Klaas Jan; Roerdink Jos B T M; van Hijum Sacha A F T; Kuipers Oscar P
Prosecutor: parameter-free inference of gene function for prokaryotes using DNA microarray data, genomic context and multiple gene annotation sources.
BMC genomics 2008;9():495.
2008: Veening Jan-Willem; Smits Wiep Klaas; Kuipers Oscar P
Bistability, epigenetics, and bet-hedging in bacteria.
Annual review of microbiology 2008;62():193-210.
2008: van der Voort Menno; Kuipers Oscar P; Buist Girbe; de Vos Willem M; Abee Tjakko
Assessment of CcpA-mediated catabolite control of gene expression in Bacillus cereus ATCC 14579.
BMC microbiology 2008;8():62.
2008: Veening Jan-Willem; Igoshin Oleg A; Eijlander Robyn T; Nijland Reindert; Hamoen Leendert W; Kuipers Oscar P
Transient heterogeneity in extracellular protease production by Bacillus subtilis.
Molecular systems biology 2008;4():184.
2008: van Hijum Sacha A F T; Baerends Richard J S; Zomer Aldert L; Karsens Harma A; Martin-Requena Victoria; Trelles Oswaldo; Kok Jan; Kuipers Oscar P
Supervised Lowess normalization of comparative genome hybridization data--application to lactococcal strain comparisons.
BMC bioinformatics 2008;9():93.
2007: Ventura Marco; Zomer Aldert; Canchaya Carlos; O'Connell-Motherway Mary; Kuipers Oscar; Turroni Francesca; Ribbera Angela; Foroni Elena; Buist Girbe; Wegmann Udo; Shearman Claire; Gasson Michael J; Fitzgerald Gerald F; Kok Jan; van Sinderen Douwe
Comparative analyses of prophage-like elements present in two Lactococcus lactis strains.
Applied and environmental microbiology 2007;73(23):7771-80.
2007: Rink Rick; Kluskens Leon D; Kuipers Anneke; Driessen Arnold J M; Kuipers Oscar P; Moll Gert N
NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides.
Biochemistry 2007;46(45):13179-89.
2007: Rink Rick; Wierenga Jenny; Kuipers Anneke; Kluskens Leon D; Driessen Arnold J M; Kuipers Oscar P; Moll Gert N
Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation.
Applied and environmental microbiology 2007;73(18):5809-16.
2007: Burghout Peter; Bootsma Hester J; Kloosterman Tomas G; Bijlsma Jetta J E; de Jongh Christa E; Kuipers Oscar P; Hermans Peter W M
Search for genes essential for pneumococcal transformation: the RADA DNA repair protein plays a role in genomic recombination of donor DNA.
Journal of bacteriology 2007;189(18):6540-50.
2007: Kloosterman Tomas G; van der Kooi-Pol Magdalena M; Bijlsma Jetta J E; Kuipers Oscar P
The novel transcriptional regulator SczA mediates protection against Zn2+ stress by activation of the Zn2+-resistance gene czcD in Streptococcus pneumoniae.
Molecular microbiology 2007;65(4):1049-63.
2007: Lulko Andrzej T; Veening Jan-Willem; Buist Girbe; Smits Wiep Klaas; Blom Evert Jan; Beekman Aaron C; Bron Sierd; Kuipers Oscar P
Production and secretion stress caused by overexpression of heterologous alpha-amylase leads to inhibition of sporulation and a prolonged motile phase in Bacillus subtilis.
Applied and environmental microbiology 2007;73(16):5354-62.
2007: Smits Wiep Klaas; Bongiorni Cristina; Veening Jan-Willem; Hamoen Leendert W; Kuipers Oscar P; Perego Marta
Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilis.
Molecular microbiology 2007;65(1):103-20.
2007: Varhimo Emilia; Savijoki Kirsi; Jalava Jari; Kuipers Oscar P; Varmanen Pekka
Identification of a novel streptococcal gene cassette mediating SOS mutagenesis in Streptococcus uberis.
Journal of bacteriology 2007;189(14):5210-22.
2007: Veiga Patrick; Bulbarela-Sampieri Carmen; Furlan Sylviane; Maisons Aurélie; Chapot-Chartier Marie-Pierre; Erkelenz Michael; Mervelet Peggy; Noirot Philippe; Frees Dorte; Kuipers Oscar P; Kok Jan; Gruss Alexandra; Buist Girbe; Kulakauskas Saulius
SpxB regulates O-acetylation-dependent resistance of Lactococcus lactis peptidoglycan to hydrolysis.
The Journal of biological chemistry 2007;282(27):19342-54.
2007: Susanna Kim A; Mironczuk Aleksandra M; Smits Wiep Klaas; Hamoen Leendert W; Kuipers Oscar P
A single, specific thymine mutation in the ComK-binding site severely decreases binding and transcription activation by the competence transcription factor ComK of Bacillus subtilis.
Journal of bacteriology 2007;189(13):4718-28.
2007: Duitman Erwin H; Wyczawski Dobek; Boven Ludolf G; Venema Gerard; Kuipers Oscar P; Hamoen Leendert W
Novel methods for genetic transformation of natural Bacillus subtilis isolates used to study the regulation of the mycosubtilin and surfactin synthetases.
Applied and environmental microbiology 2007;73(11):3490-6.
2007: Blom Evert-Jan; Bosman Dinne W J; van Hijum Sacha A F T; Breitling Rainer; Tijsma Lars; Silvis Remko; Roerdink Jos B T M; Kuipers Oscar P
FIVA: Functional Information Viewer and Analyzer extracting biological knowledge from transcriptome data of prokaryotes.
Bioinformatics (Oxford, England) 2007;23(9):1161-3.
2007: Martínez Beatriz; Zomer Aldert L; Rodríguez Ana; Kok Jan; Kuipers Oscar P
Cell envelope stress induced by the bacteriocin Lcn972 is sensed by the Lactococcal two-component system CesSR.
Molecular microbiology 2007;64(2):473-86.
2007: Smits Wiep Klaas; Hoa Tran Thu; Hamoen Leendert W; Kuipers Oscar P; Dubnau David
Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein.
Molecular microbiology 2007;64(2):368-81.
2007: Romero Diego; de Vicente Antonio; Rakotoaly Rivo H; Dufour Samuel E; Veening Jan-Willem; Arrebola Eva; Cazorla Francisco M; Kuipers Oscar P; Paquot Michel; Pérez-García Alejandro
The iturin and fengycin families of lipopeptides are key factors in antagonism of Bacillus subtilis toward Podosphaera fusca.
Molecular plant-microbe interactions : MPMI 2007;20(4):430-40.
2007: Wegmann Udo; O'Connell-Motherway Mary; Zomer Aldert; Buist Girbe; Shearman Claire; Canchaya Carlos; Ventura Marco; Goesmann Alexander; Gasson Michael J; Kuipers Oscar P; van Sinderen Douwe; Kok Jan
Complete genome sequence of the prototype lactic acid bacterium Lactococcus lactis subsp. cremoris MG1363.
Journal of bacteriology 2007;189(8):3256-70.
2007: Nijland Reindert; Veening Jan-Willem; Kuipers Oscar P
A derepression system based on the Bacillus subtilis sporulation pathway offers dynamic control of heterologous gene expression.
Applied and environmental microbiology 2007;73(7):2390-3.
2007: Bijlsma Jetta J E; Burghout Peter; Kloosterman Tomas G; Bootsma Hester J; de Jong Anne; Hermans Peter W M; Kuipers Oscar P
Development of genomic array footprinting for identification of conditionally essential genes in Streptococcus pneumoniae.
Applied and environmental microbiology 2007;73(5):1514-24.
2007: Rink Rick; Wierenga Jenny; Kuipers Anneke; Kluskens Leon D; Driessen Arnold J M; Kuipers Oscar P; Moll Gert N
Production of dehydroamino acid-containing peptides by Lactococcus lactis.
Applied and environmental microbiology 2007;73(6):1792-6.
2007: Nijland Reindert; Heerlien René; Hamoen Leendert W; Kuipers Oscar P
Changing a single amino acid in Clostridium perfringens beta-toxin affects the efficiency of heterologous secretion by Bacillus subtilis.
Applied and environmental microbiology 2007;73(5):1586-93.
2007: Hendriksen Wouter T; Silva Nuno; Bootsma Hester J; Blue Clare E; Paterson Gavin K; Kerr Alison R; de Jong Anne; Kuipers Oscar P; Hermans Peter W M; Mitchell Tim J
Regulation of gene expression in Streptococcus pneumoniae by response regulator 09 is strain dependent.
Journal of bacteriology 2007;189(4):1382-9.
2007: Zomer Aldert L; Buist Girbe; Larsen Rasmus; Kok Jan; Kuipers Oscar P
Time-resolved determination of the CcpA regulon of Lactococcus lactis subsp. cremoris MG1363.
Journal of bacteriology 2007;189(4):1366-81.
2007: Nijland Reindert; Lindner Cordula; van Hartskamp Mariska; Hamoen Leendert W; Kuipers Oscar P
Heterologous production and secretion of Clostridium perfringens beta-toxoid in closely related Gram-positive hosts.
Journal of biotechnology 2007;127(3):361-72.
2007: Bosman Diederik W J; Blom Evert-Jan; Ogao Patrick J; Kuipers Oscar P; Roerdink Jos B T M
MOVE: a multi-level ontology-based visualization and exploration framework for genomic networks.
In silico biology 2007;7(1):35-59.
2007: Lulko Andrzej T; Buist Girbe; Kok Jan; Kuipers Oscar P
Transcriptome analysis of temporal regulation of carbon metabolism by CcpA in Bacillus subtilis reveals additional target genes.
Journal of molecular microbiology and biotechnology 2007;12(1-2):82-95.
2006: Kuipers Anneke; Wierenga Jenny; Rink Rick; Kluskens Leon D; Driessen Arnold J M; Kuipers Oscar P; Moll Gert N
Sec-mediated transport of posttranslationally dehydrated peptides in Lactococcus lactis.
Applied and environmental microbiology 2006;72(12):7626-33.
2006: Miethke Marcus; Westers Helga; Blom Evert-Jan; Kuipers Oscar P; Marahiel Mohamed A
Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis.
Journal of bacteriology 2006;188(24):8655-7.
2006: Neves Ana R; Pool Wietske A; Castro Rute; Mingote Ana; Santos Filipe; Kok Jan; Kuipers Oscar P; Santos Helena
The alpha-phosphoglucomutase of Lactococcus lactis is unrelated to the alpha-D-phosphohexomutase superfamily and is encoded by the essential gene pgmH.
The Journal of biological chemistry 2006;281(48):36864-73.
2006: Darmon Elise; Dorenbos Ronald; Meens Jochen; Freudl Roland; Antelmann Haike; Hecker Michael; Kuipers Oscar P; Bron Sierd; Quax Wim J; Dubois Jean-Yves F; van Dijl Jan Maarten
A disulfide bond-containing alkaline phosphatase triggers a BdbC-dependent secretion stress response in Bacillus subtilis.
Applied and environmental microbiology 2006;72(11):6876-85.
2006: Buist Girbe; Ridder Anja N J A; Kok Jan; Kuipers Oscar P
Different subcellular locations of secretome components of Gram-positive bacteria.
Microbiology (Reading, England) 2006;152(Pt 10):2867-74.
2006: Hasper Hester E; Kramer Naomi E; Smith James L; Hillman J D; Zachariah Cherian; Kuipers Oscar P; de Kruijff Ben; Breukink Eefjan
An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II.
Science (New York, N.Y.) 2006;313(5793):1636-7.
2006: Veening J-W; Smits W K; Hamoen L W; Kuipers O P
Single cell analysis of gene expression patterns of competence development and initiation of sporulation in Bacillus subtilis grown on chemically defined media.
Journal of applied microbiology 2006;101(3):531-41.
2006: Pool Wietske A; Neves Ana Rute; Kok Jan; Santos Helena; Kuipers Oscar P
Natural sweetening of food products by engineering Lactococcus lactis for glucose production.
Metabolic engineering 2006;8(5):456-64.
2006: Kloosterman Tomas G; Hendriksen Wouter T; Bijlsma Jetta J E; Bootsma Hester J; van Hijum Sacha A F T; Kok Jan; Hermans Peter W M; Kuipers Oscar P
Regulation of glutamine and glutamate metabolism by GlnR and GlnA in Streptococcus pneumoniae.
The Journal of biological chemistry 2006;281(35):25097-109.
2006: Romero Diego; Pérez-García Alejandro; Veening Jan-Willem; de Vicente Antonio; Kuipers Oscar P
Transformation of undomesticated strains of Bacillus subtilis by protoplast electroporation.
Journal of microbiological methods 2006;66(3):556-9.
2006: Lubelski Jacek; de Jong Anne; van Merkerk Ronald; Agustiandari Herfita; Kuipers Oscar P; Kok Jan; Driessen Arnold J M
LmrCD is a major multidrug resistance transporter in Lactococcus lactis.
Molecular microbiology 2006;61(3):771-81.
2006: de Jong Anne; van Hijum Sacha A F T; Bijlsma Jetta J E; Kok Jan; Kuipers Oscar P
BAGEL: a web-based bacteriocin genome mining tool.
Nucleic acids research 2006;34(Web Server issue):W273-9.
2006: Larsen Rasmus; Kloosterman Tomas G; Kok Jan; Kuipers Oscar P
GlnR-mediated regulation of nitrogen metabolism in Lactococcus lactis.
Journal of bacteriology 2006;188(13):4978-82.
2006: Kramer Naomi E; van Hijum Sacha A F T; Knol Jan; Kok Jan; Kuipers Oscar P
Transcriptome analysis reveals mechanisms by which Lactococcus lactis acquires nisin resistance.
Antimicrobial agents and chemotherapy 2006;50(5):1753-61.
2006: den Hengst Chris D; Groeneveld Maarten; Kuipers Oscar P; Kok Jan
Identification and functional characterization of the Lactococcus lactis CodY-regulated branched-chain amino acid permease BcaP (CtrA).
Journal of bacteriology 2006;188(9):3280-9.
2006: Veening Jan-Willem; Kuipers Oscar P; Brul Stanley; Hellingwerf Klaas J; Kort Remco
Effects of phosphorelay perturbations on architecture, sporulation, and spore resistance in biofilms of Bacillus subtilis.
Journal of bacteriology 2006;188(8):3099-109.
2006: Smits Wiep Klaas; Kuipers Oscar P; Veening Jan-Willem
Phenotypic variation in bacteria: the role of feedback regulation.
Nature reviews. Microbiology 2006;4(4):259-71.
2006: Susanna Kim A; Fusetti Fabrizia; Thunnissen Andy-Mark W H; Hamoen Leendert W; Kuipers Oscar P
Functional analysis of the competence transcription factor ComK of Bacillus subtilis by characterization of truncation variants.
Microbiology (Reading, England) 2006;152(Pt 2):473-83.
2006: Kloosterman Tomas G; Bijlsma Jetta J E; Kok Jan; Kuipers Oscar P
To have neighbour's fare: extending the molecular toolbox for Streptococcus pneumoniae.
Microbiology (Reading, England) 2006;152(Pt 2):351-9.
2006: van Roosmalen Maarten L; Kanninga Rolf; El Khattabi Mohamed; Neef Jolanda; Audouy Sandrine; Bosma Tjibbe; Kuipers Anneke; Post Eduard; Steen Anton; Kok Jan; Buist Girbe; Kuipers Oscar P; Robillard George; Leenhouts Kees
Mucosal vaccine delivery of antigens tightly bound to an adjuvant particle made from food-grade bacteria.
Methods (San Diego, Calif.) 2006;38(2):144-9.
2006: Bosma Tjibbe; Kanninga Rolf; Neef Jolanda; Audouy Sandrine A L; van Roosmalen Maarten L; Steen Anton; Buist Girbe; Kok Jan; Kuipers Oscar P; Robillard George; Leenhouts Kees
Novel surface display system for proteins on non-genetically modified gram-positive bacteria.
Applied and environmental microbiology 2006;72(1):880-9.
2006: Susanna Kim A; den Hengst Chris D; Hamoen Leendert W; Kuipers Oscar P
Expression of transcription activator ComK of Bacillus subtilis in the heterologous host Lactococcus lactis leads to a genome-wide repression pattern: a case study of horizontal gene transfer.
Applied and environmental microbiology 2006;72(1):404-11.
2006: Albers Casper J; Jansen Ritsert C; Kok Jan; Kuipers Oscar P; van Hijum Sacha Aft
SIMAGE: simulation of DNA-microarray gene expression data.
BMC bioinformatics 2006;7():205.
2005: Bongers Roger S; Veening Jan-Willem; Van Wieringen Maarten; Kuipers Oscar P; Kleerebezem Michiel
Development and characterization of a subtilin-regulated expression system in Bacillus subtilis: strict control of gene expression by addition of subtilin.
Applied and environmental microbiology 2005;71(12):8818-24.
2005: den Hengst Chris D; van Hijum Sacha A F T; Geurts Jan M W; Nauta Arjen; Kok Jan; Kuipers Oscar P
The Lactococcus lactis CodY regulon: identification of a conserved cis-regulatory element.
The Journal of biological chemistry 2005;280(40):34332-42.
2005: Kluskens Leon D; Kuipers Anneke; Rink Rick; de Boef Esther; Fekken Susan; Driessen Arnold J M; Kuipers Oscar P; Moll Gert N
Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin.
Biochemistry 2005;44(38):12827-34.
2005: de Vos Willem M; Kleerebezem Michiel; Kuipers Oscar P
Lactic acid bacteria - Genetics, metabolism and application.
FEMS microbiology reviews 2005;29(3):391.
2005: Neves Ana Rute; Pool Wietske A; Kok Jan; Kuipers Oscar P; Santos Helena
Overview on sugar metabolism and its control in Lactococcus lactis - the input from in vivo NMR.
FEMS microbiology reviews 2005;29(3):531-54.
2005: Kok Jan; Buist Girbe; Zomer Aldert L; van Hijum Sacha A F T; Kuipers Oscar P
Comparative and functional genomics of lactococci.
FEMS microbiology reviews 2005;29(3):411-33.
2005: van Hijum Sacha A F T; Zomer Aldert L; Kuipers Oscar P; Kok Jan
Projector 2: contig mapping for efficient gap-closure of prokaryotic genome sequence assemblies.
Nucleic acids research 2005;33(Web Server issue):W560-6.
2005: Rink Rick; Kuipers Anneke; de Boef Esther; Leenhouts Kees J; Driessen Arnold J M; Moll Gert N; Kuipers Oscar P
Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes.
Biochemistry 2005;44(24):8873-82.
2005: Steen Anton; Buist Girbe; Horsburgh Gavin J; Venema Gerard; Kuipers Oscar P; Foster Simon J; Kok Jan
AcmA of Lactococcus lactis is an N-acetylglucosaminidase with an optimal number of LysM domains for proper functioning.
The FEBS journal 2005;272(11):2854-68.
2005: Smits Wiep Klaas; Dubois Jean-Yves F; Bron Sierd; van Dijl Jan Maarten; Kuipers Oscar P
Tricksy business: transcriptome analysis reveals the involvement of thioredoxin A in redox homeostasis, oxidative stress, sulfur metabolism, and cellular differentiation in Bacillus subtilis.
Journal of bacteriology 2005;187(12):3921-30.
2005: Veening Jan-Willem; Hamoen Leendert W; Kuipers Oscar P
Phosphatases modulate the bistable sporulation gene expression pattern in Bacillus subtilis.
Molecular microbiology 2005;56(6):1481-94.
2005: Barrière Charlotte; Veiga-da-Cunha Maria; Pons Nicolas; Guédon Eric; van Hijum Sacha A F T; Kok Jan; Kuipers Oscar P; Ehrlich Dusko S; Renault Pierre
Fructose utilization in Lactococcus lactis as a model for low-GC gram-positive bacteria: its regulator, signal, and DNA-binding site.
Journal of bacteriology 2005;187(11):3752-61.
2005: Smits Wiep Klaas; Eschevins Caroline C; Susanna Kim A; Bron Sierd; Kuipers Oscar P; Hamoen Leendert W
Stripping Bacillus: ComK auto-stimulation is responsible for the bistable response in competence development.
Molecular microbiology 2005;56(3):604-14.
2005: Larsen Rasmus; Kok Jan; Kuipers Oscar P
Interaction between ArgR and AhrC controls regulation of arginine metabolism in Lactococcus lactis.
The Journal of biological chemistry 2005;280(19):19319-30.
2005: Albano Mark; Smits Wiep Klaas; Ho Linh T Y; Kraigher Barbara; Mandic-Mulec Ines; Kuipers Oscar P; Dubnau David
The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions.
Journal of bacteriology 2005;187(6):2010-9.
2005: den Hengst Chris D; Curley Peter; Larsen Rasmus; Buist Girbe; Nauta Arjen; van Sinderen Douwe; Kuipers Oscar P; Kok Jan
Probing direct interactions between CodY and the oppD promoter of Lactococcus lactis.
Journal of bacteriology 2005;187(2):512-21.
2005: Steen Anton; Palumbo Emmanuelle; Deghorain Marie; Cocconcelli Pier Sandro; Delcour Jean; Kuipers Oscar P; Kok Jan; Buist Girbe; Hols Pascal
Autolysis of Lactococcus lactis is increased upon D-alanine depletion of peptidoglycan and lipoteichoic acids.
Journal of bacteriology 2005;187(1):114-24.
2005: van Hijum Sacha A F T; de Jong Anne; Baerends Richard J S; Karsens Harma A; Kramer Naomi E; Larsen Rasmus; den Hengst Chris D; Albers Casper J; Kok Jan; Kuipers Oscar P
A generally applicable validation scheme for the assessment of factors involved in reproducibility and quality of DNA-microarray data.
BMC genomics 2005;6(1):77.
2004: Veening Jan-Willem; Smits Wiep Klaas; Hamoen Leendert W; Jongbloed Jan D H; Kuipers Oscar P
Visualization of differential gene expression by improved cyan fluorescent protein and yellow fluorescent protein production in Bacillus subtilis.
Applied and environmental microbiology 2004;70(11):6809-15.
2004: Kramer Naomi E; Smid Eddy J; Kok Jan; de Kruijff Ben; Kuipers Oscar P; Breukink Eefjan
Resistance of Gram-positive bacteria to nisin is not determined by lipid II levels.
FEMS microbiology letters 2004;239(1):157-61.
2004: Kleerebezem Michiel; Bongers Roger; Rutten Ger; de Vos Willem M; Kuipers Oscar P
Autoregulation of subtilin biosynthesis in Bacillus subtilis: the role of the spa-box in subtilin-responsive promoters.
Peptides 2004;25(9):1415-24.
2004: Campo Nathalie; Tjalsma Harold; Buist Girbe; Stepniak Dariusz; Meijer Michel; Veenhuis Marten; Westermann Martin; Müller Jörg P; Bron Sierd; Kok Jan; Kuipers Oscar P; Jongbloed Jan D H
Subcellular sites for bacterial protein export.
Molecular microbiology 2004;53(6):1583-99.
2004: Swertz Morris A; De Brock E O; Van Hijum Sacha A F T; De Jong Anne; Buist Girbe; Baerends Richard J S; Kok Jan; Kuipers Oscar P; Jansen Ritsert C
Molecular Genetics Information System (MOLGENIS): alternatives in developing local experimental genomics databases.
Bioinformatics (Oxford, England) 2004;20(13):2075-83.
2004: Tjalsma Harold; Antelmann Haike; Jongbloed Jan D H; Braun Peter G; Darmon Elise; Dorenbos Ronald; Dubois Jean-Yves F; Westers Helga; Zanen Geeske; Quax Wim J; Kuipers Oscar P; Bron Sierd; Hecker Michael; van Dijl Jan Maarten
Proteomics of protein secretion by Bacillus subtilis: separating the "secrets" of the secretome.
Microbiology and molecular biology reviews : MMBR 2004;68(2):207-33.
2004: Kuipers Anneke; de Boef Esther; Rink Rick; Fekken Susan; Kluskens Leon D; Driessen Arnold J M; Leenhouts Kees; Kuipers Oscar P; Moll Gert N
NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides.
The Journal of biological chemistry 2004;279(21):22176-82.
2004: van den Bogaard Patrick T C; Hols Pascal; Kuipers Oscar P; Kleerebezem Michiel; de Vos Willem M
Sugar utilisation and conservation of the gal-lac gene cluster in Streptococcus thermophilus.
Systematic and applied microbiology 2004;27(1):10-7.
2004: Larsen Rasmus; Buist Girbe; Kuipers Oscar P; Kok Jan
ArgR and AhrC are both required for regulation of arginine metabolism in Lactococcus lactis.
Journal of bacteriology 2004;186(4):1147-57.
2004: Susanna K A; van der Werff A F; den Hengst C D; Calles B; Salas M; Venema G; Hamoen L W; Kuipers O P
Mechanism of transcription activation at the comG promoter by the competence transcription factor ComK of Bacillus subtilis.
Journal of bacteriology 2004;186(4):1120-8.
2004: Lindner Cordula; Nijland Reindert; van Hartskamp Mariska; Bron Sierd; Hamoen Leendert W; Kuipers Oscar P
Differential expression of two paralogous genes of Bacillus subtilis encoding single-stranded DNA binding protein.
Journal of bacteriology 2004;186(4):1097-105.
2004: Westers H; Darmon E; Zanen G; Veening J-W; Kuipers O P; Bron S; Quax W J; van Dijl J M
The Bacillus secretion stress response is an indicator for alpha-amylase production levels.
Letters in applied microbiology 2004;39(1):65-73.
2004: Baerends Richard J S; Smits Wiep Klaas; de Jong Anne; Hamoen Leendert W; Kok Jan; Kuipers Oscar P
Genome2D: a visualization tool for the rapid analysis of bacterial transcriptome data.
Genome biology 2004;5(5):R37.
2004: Tjalsma H; Koetje E J; Kiewiet R; Kuipers O P; Kolkman M; van der Laan J; Daskin R; Ferrari E; Bron S
Engineering of quorum-sensing systems for improved production of alkaline protease by Bacillus subtilis.
Journal of applied microbiology 2004;96(3):569-78.
2003: Westers Helga; Dorenbos Ronald; van Dijl Jan Maarten; Kabel Jorrit; Flanagan Tony; Devine Kevin M; Jude Florence; Seror Simone J; Beekman Aaron C; Darmon Elise; Eschevins Caroline; de Jong Anne; Bron Sierd; Kuipers Oscar P; Albertini Alessandra M; Antelmann Haike; Hecker Michael; Zamboni Nicola; Sauer Uwe; Bruand Claude; Ehrlich Dusko S; Alonso Juan C; Salas Margarita; Quax Wim J
Genome engineering reveals large dispensable regions in Bacillus subtilis.
Molecular biology and evolution 2003;20(12):2076-90.
2003: van Hijum Sacha A F T; Zomer Aldert L; Kuipers Oscar P; Kok Jan
Projector: automatic contig mapping for gap closure purposes.
Nucleic acids research 2003;31(22):e144.
2003: Kemperman Robèr; Jonker Marnix; Nauta Arjen; Kuipers Oscar P; Kok Jan
Functional analysis of the gene cluster involved in production of the bacteriocin circularin A by Clostridium beijerinckii ATCC 25752.
Applied and environmental microbiology 2003;69(10):5839-48.
2003: Gajic Olivera; Buist Girbe; Kojic Milan; Topisirovic Ljubisa; Kuipers Oscar P; Kok Jan
Novel mechanism of bacteriocin secretion and immunity carried out by lactococcal multidrug resistance proteins.
The Journal of biological chemistry 2003;278(36):34291-8.
2003: van Hijum Sacha A F T; de Jong Anne; Buist Girbe; Kok Jan; Kuipers Oscar P
UniFrag and GenomePrimer: selection of primers for genome-wide production of unique amplicons.
Bioinformatics (Oxford, England) 2003;19(12):1580-2.
2003: Antelmann Haike; Darmon Elise; Noone David; Veening Jan-Willem; Westers Helga; Bron Sierd; Kuipers Oscar P; Devine Kevin M; Hecker Michael; van Dijl Jan Maarten
The extracellular proteome of Bacillus subtilis under secretion stress conditions.
Molecular microbiology 2003;49(1):143-56.
2003: Steen Anton; Buist Girbe; Leenhouts Kees J; El Khattabi Mohamed; Grijpstra Froukje; Zomer Aldert L; Venema Gerard; Kuipers Oscar P; Kok Jan
Cell wall attachment of a widely distributed peptidoglycan binding domain is hindered by cell wall constituents.
The Journal of biological chemistry 2003;278(26):23874-81.
2003: Kemperman Robèr; Kuipers Anneke; Karsens Harma; Nauta Arjen; Kuipers Oscar; Kok Jan
Identification and characterization of two novel clostridial bacteriocins, circularin A and closticin 574.
Applied and environmental microbiology 2003;69(3):1589-97.
2003: Kleerebezem Michiel; Boekhorst Jos; van Kranenburg Richard; Molenaar Douwe; Kuipers Oscar P; Leer Rob; Tarchini Renato; Peters Sander A; Sandbrink Hans M; Fiers Mark W E J; Stiekema Willem; Lankhorst René M Klein; Bron Peter A; Hoffer Sally M; Groot Masja N Nierop; Kerkhoven Robert; de Vries Maaike; Ursing Björn; de Vos Willem M; Siezen Roland J
Complete genome sequence of Lactobacillus plantarum WCFS1.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1990-5.
2003: Hamoen Leendert W; Venema Gerard; Kuipers Oscar P
Controlling competence in Bacillus subtilis: shared use of regulators.
Microbiology (Reading, England) 2003;149(Pt 1):9-17.
2003: van Hijum Sacha A F T; García de la Nava Jorge; Trelles Oswaldo; Kok Jan; Kuipers Oscar P
MicroPreP: a cDNA microarray data pre-processing framework.
Applied bioinformatics 2003;2(4):241-4.
2002: Hamoen Leendert W; Smits Wiep Klaas; de Jong Anne; Holsappel Siger; Kuipers Oscar P
Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach.
Nucleic acids research 2002;30(24):5517-28.
2002: Darmon Elise; Noone David; Masson Anne; Bron Sierd; Kuipers Oscar P; Devine Kevin M; van Dijl Jan Maarten
A novel class of heat and secretion stress-responsive genes is controlled by the autoregulated CssRS two-component system of Bacillus subtilis.
Journal of bacteriology 2002;184(20):5661-71.
2002: Kuipers Oscar P; de Jong Anne; Baerends Richard J S; van Hijum Sacha A F T; Zomer Aldert L; Karsens Harma A; den Hengst Chris D; Kramer Naomi E; Buist Girbe; Kok Jan
Transcriptome analysis and related databases of Lactococcus lactis.
Antonie van Leeuwenhoek 2002;82(1-4):113-22.
2002: Fernández María; Kleerebezem Michiel; Kuipers Oscar P; Siezen Roland J; van Kranenburg Richard
Regulation of the metC-cysK operon, involved in sulfur metabolism in Lactococcus lactis.
Journal of bacteriology 2002;184(1):82-90.
2001: Miladinov N; Kuipers O P; Topisirovic L
Casitone-mediated expression of the prtP and prtM genes in Lactococcus lactis subsp. lactis BGIS29.
Archives of microbiology 2001;177(1):54-61.
2001: Wouters J A; Frenkiel H; de Vos W M; Kuipers O P; Abee T
Cold shock proteins of Lactococcus lactis MG1363 are involved in cryoprotection and in the production of cold-induced proteins.
Applied and environmental microbiology 2001;67(11):5171-8.
2001: Gunnewijk M G; van den Bogaard P T; Veenhoff L M; Heuberger E H; de Vos W M; Kleerebezem M; Kuipers O P; Poolman B
Hierarchical control versus autoregulation of carbohydrate utilization in bacteria.
Journal of molecular microbiology and biotechnology 2001;3(3):401-13.
2001: Kuipers O P
Complete DNA sequence of Lactococcus lactis adds flavor to genomics.
Genome research 2001;11(5):673-4.
2001: Vaughan E E; van den Bogaard P T; Catzeddu P; Kuipers O P; de Vos W M
Activation of silent gal genes in the lac-gal regulon of Streptococcus thermophilus.
Journal of bacteriology 2001;183(4):1184-94.
2001: Wiedemann I; Breukink E; van Kraaij C; Kuipers O P; Bierbaum G; de Kruijff B; Sahl H G
Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity.
The Journal of biological chemistry 2001;276(3):1772-9.
2000: Kuipers O P; Buist G; Kok J
Current strategies for improving food bacteria.
Research in microbiology 2000;151(10):815-22.
2000: van den Bogaard P T; Kleerebezem M; Kuipers O P; de Vos W M
Control of lactose transport, beta-galactosidase activity, and glycolysis by CcpA in Streptococcus thermophilus: evidence for carbon catabolite repression by a non-phosphoenolpyruvate-dependent phosphotransferase system sugar.
Journal of bacteriology 2000;182(21):5982-9.
2000: Wouters J A; Mailhes M; Rombouts F M; de Vos W M; Kuipers O P; Abee T
Physiological and regulatory effects of controlled overproduction of five cold shock proteins of Lactococcus lactis MG1363.
Applied and environmental microbiology 2000;66(9):3756-63.
2000: Wouters J A; Kamphuis H H; Hugenholtz J; Kuipers O P; de Vos W M; Abee T
Changes in glycolytic activity of Lactococcus lactis induced by low temperature.
Applied and environmental microbiology 2000;66(9):3686-91.
2000: Wouters J A; Rombouts F M; Kuipers O P; de Vos W M; Abee T
The role of cold-shock proteins in low-temperature adaptation of food-related bacteria.
Systematic and applied microbiology 2000;23(2):165-73.
2000: Konings W N; Kok J; Kuipers O P; Poolman B
Lactic acid bacteria: the bugs of the new millennium.
Current opinion in microbiology 2000;3(3):276-82.
2000: van Kraaij C; Breukink E; Rollema H S; Bongers R S; Kosters H A; de Kruijff B; Kuipers O P
Engineering a disulfide bond and free thiols in the lantibiotic nisin Z.
European journal of biochemistry / FEBS 2000;267(3):901-9.
2000: Fernández M; van Doesburg W; Rutten G A; Marugg J D; Alting A C; van Kranenburg R; Kuipers O P
Molecular and functional analyses of the metC gene of Lactococcus lactis, encoding cystathionine beta-lyase.
Applied and environmental microbiology 2000;66(1):42-8.
1999: Breukink E; Wiedemann I; van Kraaij C; Kuipers O P; Sahl H; de Kruijff B
Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic.
Science (New York, N.Y.) 1999;286(5448):2361-4.
1999: Wouters J A; Jeynov B; Rombouts F M; de Vos W M; Kuipers O P; Abee T
Analysis of the role of 7 kDa cold-shock proteins of Lactococcus lactis MG1363 in cryoprotection.
Microbiology (Reading, England) 1999;145 ( Pt 11)():3185-94.
1999: van Kraaij C; de Vos W M; Siezen R J; Kuipers O P
Lantibiotics: biosynthesis, mode of action and applications.
Natural product reports 1999;16(5):575-87.
1999: Kuipers O P
Genomics for food biotechnology: prospects of the use of high-throughput technologies for the improvement of food microorganisms.
Current opinion in biotechnology 1999;10(5):511-6.
1999: Wouters J A; Rombouts F M; de Vos W M; Kuipers O P; Abee T
Cold shock proteins and low-temperature response of Streptococcus thermophilus CNRZ302.
Applied and environmental microbiology 1999;65(10):4436-42.
1999: Kuipers O P; de Jong A; Holsappel S; Bron S; Kok J; Hamoen L W
DNA-microarrays and food-biotechnology.
Antonie van Leeuwenhoek 1999;76(1-4):353-5.
1999: Ra R; Beerthuyzen M M; de Vos W M; Saris P E; Kuipers O P
Effects of gene disruptions in the nisin gene cluster of Lactococcus lactis on nisin production and producer immunity.
Microbiology (Reading, England) 1999;145 ( Pt 5)():1227-33.
1999: Luesink E J; Marugg J D; Kuipers O P; de Vos W M
Characterization of the divergent sacBK and sacAR operons, involved in sucrose utilization by Lactococcus lactis.
Journal of bacteriology 1999;181(6):1924-6.
1999: Luesink E J; Beumer C M; Kuipers O P; De Vos W M
Molecular characterization of the Lactococcus lactis ptsHI operon and analysis of the regulatory role of HPr.
Journal of bacteriology 1999;181(3):764-71.
1998: Luesink E J; van Herpen R E; Grossiord B P; Kuipers O P; de Vos W M
Transcriptional activation of the glycolytic las operon and catabolite repression of the gal operon in Lactococcus lactis are mediated by the catabolite control protein CcpA.
Molecular microbiology 1998;30(4):789-98.
1998: van Kraaij C; Breukink E; Noordermeer M A; Demel R A; Siezen R J; Kuipers O P; de Kruijff B
Pore formation by nisin involves translocation of its C-terminal part across the membrane.
Biochemistry 1998;37(46):16033-40.
1998: Wouters J A; Sanders J W; Kok J; de Vos W M; Kuipers O P; Abee T
Clustered organization and transcriptional analysis of a family of five csp genes of Lactococcus lactis MG1363.
Microbiology (Reading, England) 1998;144 ( Pt 10)():2885-93.
1998: Breukink E; van Kraaij C; van Dalen A; Demel R A; Siezen R J; de Kruijff B; Kuipers O P
The orientation of nisin in membranes.
Biochemistry 1998;37(22):8153-62.
1997: van den Hooven H W; Rollema H S; Siezen R J; Hilbers C W; Kuipers O P
Structural features of the final intermediate in the biosynthesis of the lantibiotic nisin. Influence of the leader peptide.
Biochemistry 1997;36(46):14137-45.
1997: Van Kraaij C; Breukink E; Rollema H S; Siezen R J; Demel R A; De Kruijff B; Kuipers O P
Influence of charge differences in the C-terminal part of nisin on antimicrobial activity and signaling capacity.
European journal of biochemistry / FEBS 1997;247(1):114-20.
1997: Breukink E; van Kraaij C; Demel R A; Siezen R J; Kuipers O P; de Kruijff B
The C-terminal region of nisin is responsible for the initial interaction of nisin with the target membrane.
Biochemistry 1997;36(23):6968-76.
1996: Rollema H S; Metzger J W; Both P; Kuipers O P; Siezen R J
Structure and biological activity of chemically modified nisin A species.
European journal of biochemistry / FEBS 1996;241(3):716-22.
1996: de Ruyter P G; Kuipers O P; de Vos W M
Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin.
Applied and environmental microbiology 1996;62(10):3662-7.
1996: van den Hooven H W; Lagerwerf F M; Heerma W; Haverkamp J; Piard J C; Hilbers C W; Siezen R J; Kuipers O P; Rollema H S
The structure of the lantibiotic lacticin 481 produced by Lactococcus lactis: location of the thioether bridges.
FEBS letters 1996;391(3):317-22.
1996: de Ruyter P G; Kuipers O P; Beerthuyzen M M; van Alen-Boerrigter I; de Vos W M
Functional analysis of promoters in the nisin gene cluster of Lactococcus lactis.
Journal of bacteriology 1996;178(12):3434-9.
1996: Kuipers O P; Bierbaum G; Ottenwälder B; Dodd H M; Horn N; Metzger J; Kupke T; Gnau V; Bongers R; van den Bogaard P; Kosters H; Rollema H S; de Vos W M; Siezen R J; Jung G; Götz F; Sahl H G; Gasson M J
Protein engineering of lantibiotics.
Antonie van Leeuwenhoek 1996;69(2):161-69.
1996: Demel R A; Peelen T; Siezen R J; De Kruijff B; Kuipers O P
Nisin Z, mutant nisin Z and lacticin 481 interactions with anionic lipids correlate with antimicrobial activity. A monolayer study.
European journal of biochemistry / FEBS 1996;235(1-2):267-74.
1995: Kuipers O P; Beerthuyzen M M; de Ruyter P G; Luesink E J; de Vos W M
Autoregulation of nisin biosynthesis in Lactococcus lactis by signal transduction.
The Journal of biological chemistry 1995;270(45):27299-304.
1995: de Vos W M; Kuipers O P; van der Meer J R; Siezen R J
Maturation pathway of nisin and other lantibiotics: post-translationally modified antimicrobial peptides exported by gram-positive bacteria.
Molecular microbiology 1995;17(3):427-37.
1995: Rollema H S; Kuipers O P; Both P; de Vos W M; Siezen R J
Improvement of solubility and stability of the antimicrobial peptide nisin by protein engineering.
Applied and environmental microbiology 1995;61(8):2873-8.
1995: van de Kamp M; van den Hooven H W; Konings R N; Bierbaum G; Sahl H G; Kuipers O P; Siezen R J; de Vos W M; Hilbers C W; van de Ven F J
Elucidation of the primary structure of the lantibiotic epilancin K7 from Staphylococcus epidermidis K7. Cloning and characterisation of the epilancin-K7-encoding gene and NMR analysis of mature epilancin K7.
European journal of biochemistry / FEBS 1995;230(2):587-600.
1995: Siezen R J; Rollema H S; Kuipers O P; de Vos W M
Homology modelling of the Lactococcus lactis leader peptidase NisP and its interaction with the precursor of the lantibiotic nisin.
Protein engineering 1995;8(2):117-25.
1995: De Vos W M; Beerthuyzen M M; Luesink E L; Kuipers O P
Genetics of the nisin operon and the sucrose-nisin conjugative transposon Tn5276.
Developments in biological standardization 1995;85():617-25.
1995: Kuipers O P; Rollema H S; Siezen R J; De Vos W M
Lactococcal expression systems for protein engineering of nisin.
Developments in biological standardization 1995;85():605-13.
1994: van der Meer J R; Rollema H S; Siezen R J; Beerthuyzen M M; Kuipers O P; de Vos W M
Influence of amino acid substitutions in the nisin leader peptide on biosynthesis and secretion of nisin by Lactococcus lactis.
The Journal of biological chemistry 1994;269(5):3555-62.
1993: Kuipers O P; Rollema H S; de Vos W M; Siezen R J
Biosynthesis and secretion of a precursor of nisin Z by Lactococcus lactis, directed by the leader peptide of the homologous lantibiotic subtilin from Bacillus subtilis.
FEBS letters 1993;330(1):23-7.
1993: Piard J C; Kuipers O P; Rollema H S; Desmazeaud M J; de Vos W M
Structure, organization, and expression of the lct gene for lacticin 481, a novel lantibiotic produced by Lactococcus lactis.
The Journal of biological chemistry 1993;268(22):16361-8.
1993: Kuipers O P; Beerthuyzen M M; Siezen R J; De Vos W M
Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity.
European journal of biochemistry / FEBS 1993;216(1):281-91.
1993: van der Meer J R; Polman J; Beerthuyzen M M; Siezen R J; Kuipers O P; De Vos W M
Characterization of the Lactococcus lactis nisin A operon genes nisP, encoding a subtilisin-like serine protease involved in precursor processing, and nisR, encoding a regulatory protein involved in nisin biosynthesis.
Journal of bacteriology 1993;175(9):2578-88.
1993: Spee J H; de Vos W M; Kuipers O P
Efficient random mutagenesis method with adjustable mutation frequency by use of PCR and dITP.
Nucleic acids research 1993;21(3):777-8.
1993: de Vos W M; Mulders J W; Siezen R J; Hugenholtz J; Kuipers O P
Properties of nisin Z and distribution of its gene, nisZ, in Lactococcus lactis.
Applied and environmental microbiology 1993;59(1):213-8.
1992: Kuipers O P; Rollema H S; Yap W M; Boot H J; Siezen R J; de Vos W M
Engineering dehydrated amino acid residues in the antimicrobial peptide nisin.
The Journal of biological chemistry 1992;267(34):24340-6.
1991: Kuipers O P; Boot H J; de Vos W M
Improved site-directed mutagenesis method using PCR.
Nucleic acids research 1991;19(16):4558.
1990: Kuipers O P; Franken P A; Hendriks R; Verheij H M; de Haas G H
Function of the fully conserved residues Asp99, Tyr52 and Tyr73 in phospholipase A2.
Protein engineering 1990;4(2):199-204.
1990: Kuipers O P; Kerver J; van Meersbergen J; Vis R; Dijkman R; Verheij H M; de Haas G H
Influence of size and polarity of residue 31 in porcine pancreatic phospholipase A2 on catalytic properties.
Protein engineering 1990;3(7):599-603.
1990: Kuipers O P; Dekker N; Verheij H M; de Haas G H
Activities of native and tyrosine-69 mutant phospholipases A2 on phospholipid analogues. A reevaluation of the minimal substrate requirements.
Biochemistry 1990;29(25):6094-102.
1990: Kuipers O P; van den Bergh C J; Verheij H M; de Haas G H
Probing the mechanism of pancreatic phospholipase A2 with the aid of recombinant DNA techniques.
Advances in experimental medicine and biology 1990;279():65-84.
1989: Kuipers O P; Thunnissen M M; de Geus P; Dijkstra B W; Drenth J; Verheij H M; de Haas G H
Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop.
Science (New York, N.Y.) 1989;244(4900):82-5.
1989: Kuipers O P; Dijkman R; Pals C E; Verheij H M; de Haas G H
Evidence for the involvement of tyrosine-69 in the control of stereospecificity of porcine pancreatic phospholipase A2.
Protein engineering 1989;2(6):467-71.
1987: de Geus P; van den Bergh C J; Kuipers O; Verheij H M; Hoekstra W P; de Haas G H
Expression of porcine pancreatic phospholipase A2. Generation of active enzyme by sequence-specific cleavage of a hybrid protein from Escherichia coli.
Nucleic acids research 1987;15(9):3743-59.

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