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Akiko Kukita

Research Profile

Anatomy

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Reverse Transcriptase Polymerase Chain Reaction

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Akira Takahashi; Takayoshi Yamaza; Jing-Qi Zhang; Yin-Ji Li; Hisayuki Nomiyama; Yasunori Ayukawa; Kiyoshi Koyano; Akiko Kukita; Toshio Kukita
Tunneling nanotube formation is essential for the regulation of osteoclastogenesis.
Junpei Teramachi; Naohisa Wada; Akiko Kukita; Yin-Ji Li; Seiji Nakamura; Pengfei Qu; Toshio Kukita
Adenosine blocks aminopterin-induced suppression of osteoclast differentiation.
Yin-Ji Li; Yuzo Ninomiya; Pengfei Qu; Keisuke Sanematsu; Toshio Takano; Toshiyuki Watanabe; Akiko Kukita; Toshio Kukita
Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats.

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2013: Akira Takahashi; Takayoshi Yamaza; Jing-Qi Zhang; Yin-Ji Li; Hisayuki Nomiyama; Yasunori Ayukawa; Kiyoshi Koyano; Akiko Kukita; Toshio Kukita
Tunneling nanotube formation is essential for the regulation of osteoclastogenesis.
Journal of cellular biochemistry 2013;114(6):1238-47.
2013: Junpei Teramachi; Naohisa Wada; Akiko Kukita; Yin-Ji Li; Seiji Nakamura; Pengfei Qu; Toshio Kukita
Adenosine blocks aminopterin-induced suppression of osteoclast differentiation.
Journal of bone and mineral metabolism 2013;31(1):64-70.
2012: Yin-Ji Li; Yuzo Ninomiya; Pengfei Qu; Keisuke Sanematsu; Toshio Takano; Toshiyuki Watanabe; Akiko Kukita; Toshio Kukita
Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats.
Laboratory investigation; a journal of technical methods and pathology 2012;92(12):1777-87.
2012: Nanako Katagiri; Akiko Kukita; Bin Chang; Takeo Shobuike; Hiroshi Miyamoto
The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila.
Microbes and infection / Institut Pasteur 2012;14(13):1123-32.
2012: Rei Matsubara; Hiroshi Miyamoto; Kazuaki Nonaka; Peng-Fei Qu; Ippei Takigawa; Noboru Funakubo; Yuka Ichigi; Toshio Kukita; Akiko Kukita
Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-α in combination with TGF-β in rats.
PloS one 2012;7(10):e47930.
2012: Akiko Kukita; Toshio Kukita; Ippei Takigawa; Toshiyuki Watanabe; Yuka Ichigi; Hiroshi Miyamoto
Infection of RANKL-primed RAW-D macrophages with Porphyromonas gingivalis promotes osteoclastogenesis in a TNF-α-independent manner.
PloS one 2012;7(6):e38500.
2011: Akiko Kukita; Toshio Kukita; Yin-Ji Li; Hiroshi Miyamoto; Kengo Nagata; Frank Pessler; Junpei Teramachi; Hiroki Yoshida; Steffen Gay; Takeo Shobuike
The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo.
Arthritis and rheumatism 2011;63(9):2744-54.
2011: Junpei Teramachi; Akiko Kukita; Yin-Ji Li; Yuki Ushijima; Hiroshi Ohkuma; Naohisa Wada; Toshiyuki Watanabe; Seiji Nakamura; Toshio Kukita
Adenosine abolishes MTX-induced suppression of osteoclastogenesis and inflammatory bone destruction in adjuvant-induced arthritis.
Laboratory investigation; a journal of technical methods and pathology 2011;91(5):719-31.
2010: Tomonori Akiyama; Hiroshi Miyamoto; Kazumasa Fukuda; Naoto Sano; Nanako Katagiri; Takeo Shobuike; Akiko Kukita; Yoshio Yamashita; Hatsumi Taniguchi; Masaaki Goto
Development of a novel PCR method to comprehensively analyze salivary bacterial flora and its application to patients with odontogenic infections.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2010;109(5):669-76.
2009: Jie Liu; Jun Shiono; Kuniyoshi Shimizu; Akiko Kukita; Toshio Kukita; Ryuichiro Kondo
Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor.
Bioorganic & medicinal chemistry letters 2009;19(8):2154-7.
2009: Yin-Ji Li; Akiko Kukita; Junpei Teramachi; Kengo Nagata; Zhou Wu; Akifumi Akamine; Toshio Kukita
A possible suppressive role of galectin-3 in upregulated osteoclastogenesis accompanying adjuvant-induced arthritis in rats.
Laboratory investigation; a journal of technical methods and pathology 2009;89(1):26-37.
2007: Kenji Ogawa; Masaaki Mawatari; Mitsunori Komine; Masamori Shigematsu; Masaru Kitajima; Akiko Kukita; Takao Hotokebuchi
Mature and activated osteoclasts exist in the synovium of rapidly destructive coxarthrosis.
Journal of bone and mineral metabolism 2007;25(6):354-60.
2006: Quan Yong Tang; Toshio Kukita; Yuki Ushijima; Akiko Kukita; Kengo Nagata; Ferry Sandra; Toshiyuki Watanabe; Kazuko Toh; Yutaka Okuma; Sadamichi Kawasaki; Linda Rasubala; Junpei Teramachi; Ichiko Miyamoto; Zhou Wu; Tadahiko Iijima
Regulation of osteoclastogenesis by Simon extracts composed of caffeic acid and related compounds: successful suppression of bone destruction accompanied with adjuvant-induced arthritis in rats.
Histochemistry and cell biology 2006;125(3):215-25.
2005: Takahiro Nakamura; Toshio Kukita; Takeo Shobuike; Kengo Nagata; Zhou Wu; Kenji Ogawa; Takao Hotokebuchi; Osamu Kohashi; Akiko Kukita
Inhibition of histone deacetylase suppresses osteoclastogenesis and bone destruction by inducing IFN-beta production.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5809-16.
2004: Toshio Kukita; Naohisa Wada; Akiko Kukita; Takashi Kakimoto; Ferry Sandra; Kazuko Toh; Kengo Nagata; Tadahiko Iijima; Madoka Horiuchi; Hiromi Matsusaki; Kunio Hieshima; Osamu Yoshie; Hisayuki Nomiyama
RANKL-induced DC-STAMP is essential for osteoclastogenesis.
The Journal of experimental medicine 2004;200(7):941-6.
2004: Kazuko Toh; Toshio Kukita; Zhou Wu; Akiko Kukita; Ferry Sandra; Quan Yong Tang; Hisayuki Nomiyama; Tadahiko Iijima
Possible involvement of MIP-1alpha in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant-induced arthritis.
Laboratory investigation; a journal of technical methods and pathology 2004;84(9):1092-102.
2004: Toshiyuki Watanabe; Toshio Kukita; Akiko Kukita; Naohisa Wada; Kazuko Toh; Kengo Nagata; Hisayuki Nomiyama; Tadahiko Iijima
Direct stimulation of osteoclastogenesis by MIP-1alpha: evidence obtained from studies using RAW264 cell clone highly responsive to RANKL.
The Journal of endocrinology 2004;180(1):193-201.
2003: Cong-Long Zheng; Kazunori Ohki; Aslam Hossain; Akiko Kukita; Toshimi Satoh; Osamu Kohashi
Complete Freund's adjuvant promotes the increases of IFN-gamma and nitric oxide in suppressing chronic arthritis induced by pristane.
Inflammation 2003;27(4):247-55.
2003: Md Mizanur Rahman; Akiko Kukita; Toshio Kukita; Takeo Shobuike; Takahiro Nakamura; Osamu Kohashi
Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages.
Blood 2003;101(9):3451-9.
2003: Toshio Kukita; Akiko Kukita
[Regulation of osteoclastic function through cell surface receptors].
Clinical calcium 2003;13(4):444-8.
2003: Toshio Kukita; Akiko Kukita; Licin Xu; Kazuko Toh; Quanyong Tang; Hisayuki Nomiyama; Tadahiko Iijima
Extremely high expression of beta-actin mRNA in osteoclasts resorbing alveolar bone located at the distal area of the developing molar tooth germ in newborn rats.
Journal of electron microscopy 2003;52(6):545-50.
2002: Cong-Long Zheng; Md Aslam Hossain; Akiko Kukita; Kazunori Ohki; Toshimi Satoh; Osamu Kohashi
Complete Freund's adjuvant suppresses the development and progression of pristane-induced arthritis in rats.
Clinical immunology (Orlando, Fla.) 2002;103(2):204-9.
2002: Hidetaka Sakai; Seiya Jingushi; T Shuto; K Urabe; T Ikenoue; Ken Okazaki; Toshio Kukita; Akiko Kukita; Yukihide Iwamoto
Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision arthroplasty induce osteoclast differentiation, as do stromal cells.
Annals of the rheumatic diseases 2002;61(2):103-9.
2001: Aslam Hossain; Cong-Long Zheng; Akiko Kukita; Osamu Kohashi
Balance of Th1/Th2 cytokines associated with the preventive effect of incomplete Freund's adjuvant on the development of adjuvant arthritis in LEW rats.
Journal of autoimmunity 2001;17(4):289-95.
2001: Toshio Kukita; Akiko Kukita; Toshiyuki Watanabe; Tadahiko Iijima
Osteoclast differentiation antigen, distinct from receptor activator of nuclear factor kappa B, is involved in osteoclastogenesis under calcitonin-regulated conditions.
The Journal of endocrinology 2001;170(1):175-83.
2001: Mitsunori Komine; Akiko Kukita; Toshio Kukita; Y Ogata; Takao Hotokebuchi; Osamu Kohashi
Tumor necrosis factor-alpha cooperates with receptor activator of nuclear factor kappaB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell culture.
Bone 2001;28(5):474-83.
2001: Toshio Kukita; Akiko Kukita; L Xu; Toshiyuki Watanabe; Tadahiko Iijima
Kat1-antigen--a reliable immunological marker for identifying osteoclast precursors of rats: detection of subpopulations among precursors and initiation of osteoclastogenesis.
Histochemistry and cell biology 2001;115(3):215-22.
2000: Toshio Kukita; Akiko Kukita; T Iijima
[Osteoclast differentiation antigen involved in the induction of calcitonin escape phenomenon].
Kaibogaku zasshi. Journal of anatomy 2000;75(5):433-8.
2000: Masafumi Zaitsu; Yuhei Hamasaki; Muneaki Matsuo; Akiko Kukita; Kohsuke Tsuji; Michiko Miyazaki; R Hayasaki; Eriko Muro; Shuichi Yamamoto; Ikuko Kobayashi; Tomohiro Ichimaru; Osamu Kohashi; S Miyazaki
New induction of leukotriene A(4) hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes.
Blood 2000;96(2):601-9.
1999: Akiko Kukita; Toshio Kukita; M Ouchida; H Maeda; H Yatsuki; Osamu Kohashi
Osteoclast-derived zinc finger (OCZF) protein with POZ domain, a possible transcriptional repressor, is involved in osteoclastogenesis.
Blood 1999;94(6):1987-97.
1999: Y Ogata; Akiko Kukita; Toshio Kukita; Mitsunori Komine; A Miyahara; S Miyazaki; Osamu Kohashi
A novel role of IL-15 in the development of osteoclasts: inability to replace its activity with IL-2.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2754-60.
1998: H Harada; Toshio Kukita; Akiko Kukita; Yukihide Iwamoto; T Iijima
Involvement of lymphocyte function-associated antigen-1 and intercellular adhesion molecule-1 in osteoclastogenesis: a possible role in direct interaction between osteoclast precursors.
Endocrinology 1998;139(9):3967-75.
1998: Toshio Kukita; Akiko Kukita; L Xu; H Maeda; Tadahiko Iijima
Successful detection of active osteoclasts in situ by systemic administration of an osteoclast-specific monoclonal antibody.
Calcified tissue international 1998;63(2):148-53.
1998: Toshio Kukita; K Hata; Akiko Kukita; Tadahiko Iijima
Laminin, a major basement membrane component of the blood vessel, as a negative regulator of osteoclastogenesis.
Calcified tissue international 1998;63(2):140-2.
1997: Toshio Kukita; Akiko Kukita; H Harada; T Iijima
Regulation of osteoclastogenesis by antisense oligodeoxynucleotides specific to zinc finger nuclear transcription factors Egr-1 and WT1 in rat bone marrow culture system.
Endocrinology 1997;138(10):4384-9.
1997: Toshio Kukita; Hisayuki Nomiyama; Y Ohmoto; Akiko Kukita; T Shuto; Takao Hotokebuchi; Yoichi Sugioka; R Miura; Tadahiko Iijima
Macrophage inflammatory protein-1 alpha (LD78) expressed in human bone marrow: its role in regulation of hematopoiesis and osteoclast recruitment.
Laboratory investigation; a journal of technical methods and pathology 1997;76(3):399-406.
1994: Toshio Kukita; Akiko Kukita; K Nagata; H Maeda; K Kurisu; T Watanabe; Tadahiko Iijima
Novel cell-surface Ag expressed on rat osteoclasts regulating the function of the calcitonin receptor.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(11):5265-73.
1994: H Maeda; Toshio Kukita; Akifumi Akamine; Akiko Kukita; Tadahiko Iijima
Localization of osteopontin in resorption lacunae formed by osteoclast-like cells: a study by a novel monoclonal antibody which recognizes rat osteopontin.
Histochemistry 1994;102(4):247-54.
1994: K Hata; Toshio Kukita; Akifumi Akamine; Akiko Kukita; K Kurisu; Tadahiko Iijima
A novel monoclonal antibody recognizing a unique antigen of rat osteoclasts induced by the calcified matrices.
Histochemistry 1994;101(5):347-54.
1992: Toshio Kukita; J Nakao; F Hamada; Akiko Kukita; Tetsuichiro Inai; K Kurisu; H Nomiyama
Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system.
Bone and mineral 1992;19(3):215-23.
1992: Akiko Kukita; H Harada; Toshio Kukita; Tetsuichiro Inai; S Matsuhashi; K Kurisu
Primary and secondary culture of rat ameloblasts in serum-free medium.
Calcified tissue international 1992;51(5):393-8.
1992: Toshio Kukita; Akiko Kukita; K Hata; K Kurisu
12-O-tetradecanoylphorbol-13-acetate inhibits osteoclast-like cell differentiation in rat bone marrow cultures by inducing macrophage polykaryons.
Endocrinology 1992;130(2):577-84.
1992: K Hata; Toshio Kukita; A Akamine; Akiko Kukita; K Kurisu
Trypsinized osteoclast-like multinucleated cells formed in rat bone marrow cultures efficiently form resorption lacunae on dentine.
Bone 1992;13(2):139-46.
1991: Tetsuichiro Inai; Toshio Kukita; Y Ohsaki; K Nagata; Akiko Kukita; K Kurisu
Immunohistochemical demonstration of amelogenin penetration toward the dental pulp in the early stages of ameloblast development in rat molar tooth germs.
The Anatomical record 1991;229(2):259-70.