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Rakesh Kukreja

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Saisudha Koka; Anindita Das; Fadi Salloum; Rakesh C Kukreja
Phosphodiesterase-5 inhibitor tadalafil attenuates oxidative stress and protects against myocardial ischemia/reperfusion injury in type 2 diabetic mice.
Aditi R Chiplunkar; Jack L Haar; Benjamin A Koppenhaver; Rakesh C Kukreja; Tina K Lung; Fadi Salloum; Yousef Alhashem; Joyce A Lloyd
Krüppel-like factor 2 is required for normal mouse cardiac development.
Anindita Das; David Durrant; Ramzi Ockaili; Fadi Salloum; Rakesh C Kukreja
Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway.

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2013: Saisudha Koka; Anindita Das; Fadi Salloum; Rakesh C Kukreja
Phosphodiesterase-5 inhibitor tadalafil attenuates oxidative stress and protects against myocardial ischemia/reperfusion injury in type 2 diabetic mice.
Free radical biology & medicine 2013;60():80-8.
2013: Aditi R Chiplunkar; Jack L Haar; Benjamin A Koppenhaver; Rakesh C Kukreja; Tina K Lung; Fadi Salloum; Yousef Alhashem; Joyce A Lloyd
Krüppel-like factor 2 is required for normal mouse cardiac development.
PloS one 2013;8(2):e54891.
2012: Anindita Das; David Durrant; Ramzi Ockaili; Fadi Salloum; Rakesh C Kukreja
Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway.
Journal of molecular and cellular cardiology 2012;53(6):858-69.
2012: Rakesh C Kukreja
Phosphodiesterase-5 and retargeting of subcellular cGMP signaling during pathological hypertrophy.
Circulation 2012;126(8):916-9.
2012: Rakesh C Kukreja; Fadi Salloum; Anindita Das
Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection.
Journal of the American College of Cardiology 2012;59(22):1921-7.
2012: Lei Xi; Shu-Guang Zhu; Edward J Lesnefsky; Qun Chen; Anindita Das; David Durrant; Daniel C Hobbs; Rakesh C Kukreja
Dietary inorganic nitrate alleviates doxorubicin cardiotoxicity: mechanisms and implications.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2012;26(4):274-84.
2012: Shu-Guang Zhu; Lei Xi; Rakesh C Kukreja
Type 2 diabetic obese db/db mice are refractory to myocardial ischaemic post-conditioning in vivo: potential role for Hsp20, F1-ATPase δ and Echs1.
Journal of cellular and molecular medicine 2012;16(4):950-8.
2012: Fadi Salloum; Arun Samidurai; Johannes-Peter Stasch; Ramzi Ockaili; Vinh Q Chau; Anindita Das; Nicholas N Hoke; Rakesh C Kukreja
Cinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia/reperfusion injury: role of hydrogen sulfide.
American journal of physiology. Heart and circulatory physiology 2012;302(6):H1347-54.
2012: Saisudha Koka; Lei Xi; Rakesh C Kukreja
Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts.
Basic research in cardiology 2012;107(2):249.
2012: Nicholas N Hoke; David A Kass; Anindita Das; Fadi Salloum; Rakesh C Kukreja
Preconditioning by phosphodiesterase-5 inhibition improves therapeutic efficacy of adipose-derived stem cells following myocardial infarction in mice.
Stem cells (Dayton, Ohio) 2012;30(2):326-35.
2012: Amit Varma; Fadi Salloum; Anindita Das; David E Durrant; Nicholas N Hoke; Rakesh C Kukreja
Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice.
PloS one 2012;7(9):e45243.
2011: Lei Xi; Shu-Guang Zhu; Daniel C Hobbs; Rakesh C Kukreja
Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.
Journal of cellular and molecular medicine 2011;15(11):2512-24.
2011: Rakesh C Kukreja; Chang Yin; Fadi Salloum
MicroRNAs: new players in cardiac injury and protection.
Molecular pharmacology 2011;80(4):558-64.
2011: Karol Szczepanek; Magdalena Szelag; Qifang Zhang; Edward J Lesnefsky; Fadi N Salloum; Qun Chen; Joanna Cichy; Marta Derecka; Jozef Dulak; Rakesh C Kukreja; Andrew C Larner
Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species.
The Journal of biological chemistry 2011;286(34):29610-20.
2011: Jose F Huizar; Karoly Kaszala; Rakesh C Kukreja; Edward J Lesnefsky; Eleonora Mezzaroma; Anthony J Minisi; Jonathan Potfay; Leroy R Thacker; Antonio Abbate; Qun Chen; Kenneth A Ellenbogen; Nicholas N Hoke; Mark A Wood
Left ventricular systolic dysfunction induced by ventricular ectopy: a novel model for premature ventricular contraction-induced cardiomyopathy.
Circulation. Arrhythmia and electrophysiology 2011;4(4):543-9.
2011: Vinh Q Chau; Fadi Salloum; Nicholas N Hoke; Antonio Abbate; Rakesh C Kukreja
Mitigation of the progression of heart failure with sildenafil involves inhibition of RhoA/Rho-kinase pathway.
American journal of physiology. Heart and circulatory physiology 2011;300(6):H2272-9.
2011: Shu-Guang Zhu; Rakesh C Kukreja; Anindita Das; Qun Chen; Edward J Lesnefsky; Lei Xi
Dietary nitrate supplementation protects against Doxorubicin-induced cardiomyopathy by improving mitochondrial function.
Journal of the American College of Cardiology 2011;57(21):2181-9.
2011: Rakesh C Kukreja; Ramzi Ockaili; Fadi Salloum; Anindita Das; Saisudha Koka; Lei Xi
Emerging new uses of phosphodiesterase-5 inhibitors in cardiovascular diseases.
Experimental and clinical cardiology 2011;16(4):e30-5.
2011: Matthew A Movsesian; Rakesh C Kukreja
Phosphodiesterase inhibition in heart failure.
Handbook of experimental pharmacology 2011;(204):237-49.
2010: Fadi Salloum; Chang Yin; Rakesh C Kukreja
Role of microRNAs in cardiac preconditioning.
Journal of cardiovascular pharmacology 2010;56(6):581-8.
2010: Anindita Das; David Durrant; Clint Mitchell; Eric Mayton; Nicholas N Hoke; Fadi Salloum; Margaret A Park; Ian Qureshi; Ray Lee; Paul Dent; Rakesh C Kukreja
Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(42):18202-7.
2010: Christine Farthing; Don Farthing; Saisudha Koka; Terri Larus; Itaf Fakhry; Lei Xi; Rakesh C Kukreja; Domenic Sica; Todd W B Gehr
A simple and sensitive HPLC fluorescence method for determination of tadalafil in mouse plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(28):2891-5.
2010: Siddhartha S Ghosh; Fadi Salloum; Antonio Abbate; Richard Krieg; Domenic A Sica; Todd W Gehr; Rakesh C Kukreja
Curcumin prevents cardiac remodeling secondary to chronic renal failure through deactivation of hypertrophic signaling in rats.
American journal of physiology. Heart and circulatory physiology 2010;299(4):H975-84.
2010: Saisudha Koka; Anindita Das; Shu-Guang Zhu; David Durrant; Lei Xi; Rakesh C Kukreja
Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect.
The Journal of pharmacology and experimental therapeutics 2010;334(3):1023-30.
2009: Fadi Salloum; Vinh Q Chau; Nicholas N Hoke; Antonio Abbate; Amit Varma; Ramzi Ockaili; Stefano Toldo; Rakesh C Kukreja
Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide.
Circulation 2009;120(11 Suppl):S31-6.
2009: N N Hoke; Fadi Salloum; K E Loesser-Casey; Rakesh C Kukreja
Cardiac regenerative potential of adipose tissue-derived stem cells.
Acta physiologica Hungarica 2009;96(3):251-65.
2009: Fabrice Vandeput; Judith Krall; Ramzi Ockaili; Fadi N Salloum; Vincent Florio; Jackie D Corbin; Sharron H Francis; Rakesh C Kukreja; Matthew A Movsesian
cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium.
The Journal of pharmacology and experimental therapeutics 2009;330(3):884-91.
2009: Anindita Das; Fadi Salloum; Lei Xi; Yuan J Rao; Rakesh C Kukreja
ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice.
American journal of physiology. Heart and circulatory physiology 2009;296(5):H1236-43.
2009: Chang Yin; Fadi Salloum; Rakesh C Kukreja
A novel role of microRNA in late preconditioning: upregulation of endothelial nitric oxide synthase and heat shock protein 70.
Circulation research 2009;104(5):572-5.
2009: David Durrant; Frank Corwin; Daniele Simoni; Ming Zhao; MICHELLE RUDEK-RENAUT; Fadi N Salloum; Rakesh C Kukreja; Panos P Fatouros; Ray M Lee
cis-3, 4', 5-Trimethoxy-3'-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusion.
Cancer chemotherapy and pharmacology 2009;63(2):191-200.
2008: Chang Yin; Xiaoyin Wang; Rakesh C Kukreja
Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia-reperfusion in mice.
FEBS letters 2008;582(30):4137-42.
2008: Lei Xi; Rakesh C Kukreja
Commentaries on viewpoint: effect of altitude on leptin, does it go up or down?
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(5):1687-8.
2008: Anindita Das; Lei Xi; Rakesh C Kukreja
Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta.
The Journal of biological chemistry 2008;283(43):29572-85.
2008: Lei Xi; Anindita Das; Zhi-Qing Zhao; Vanessa F Merino; Michael Bader; Rakesh C Kukreja
Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2 receptors gene knockout mice.
Circulation 2008;118(14 Suppl):S32-7.
2008: Antonio Abbate; Rossana Bussani; Gianfranco Sinagra; Elena Barresi; Alberto Pivetta; Andrea Perkan; Nicholas H Hoke; Fadi Salloum; Michael C Kontos; Giuseppe G L Biondi-Zoccai; George W Vetrovec; Gastone Sabbadini; Feliciano Baldi; Furio Silvestri; Rakesh C Kukreja; Alfonso Baldi
Right ventricular cardiomyocyte apoptosis in patients with acute myocardial infarction of the left ventricular wall.
The American journal of cardiology 2008;102(6):658-62.
2008: Antonio Abbate; Fadi Salloum; Elena Vecile; Anindita Das; Nicholas N Hoke; Stefania Straino; Giuseppe G L Biondi-Zoccai; Jon-Erik Houser; Ian Z Qureshi; Evan D Ownby; Edoardo Gustini; Luigi M Biasucci; Anna Severino; Maurizio C Capogrossi; George W Vetrovec; Filippo Crea; Alfonso Baldi; Rakesh C Kukreja; Aldo Dobrina
Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction.
Circulation 2008;117(20):2670-83.
2008: Fadi Salloum; Antonio Abbate; Anindita Das; Jon-Erik Houser; Colin A Mudrick; Ian Z Qureshi; Nicholas N Hoke; Sion K Roy; William R Brown; Shashi Prabhakar; Rakesh C Kukreja
Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice.
American journal of physiology. Heart and circulatory physiology 2008;294(3):H1398-406.
2008: Ramesh Natarajan; Fadi Salloum; Bernard J Fisher; Rakesh C Kukreja; Alpha A Fowler
Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury.
Journal of cardiovascular pharmacology 2008;51(2):178-87.
2008: Xiaoyin Wang; Patrick W Fisher; Lei Xi; Rakesh C Kukreja
Essential role of mitochondrial Ca2+-activated and ATP-sensitive K+ channels in sildenafil-induced late cardioprotection.
Journal of molecular and cellular cardiology 2008;44(1):105-13.
2007: Stefania Straino; Fadi Salloum; Alfonso Baldi; Ramzi Ockaili; Maddalena Piro; Anindita Das; Ian Z Qureshi; Luigi M Biasucci; Maurizio C Capogrossi; Giuseppe G L Biondi-Zoccai; Anna Severino; Pasquale Mellone; Filippo Crea; George W Vetrovec; Rakesh C Kukreja; Antonio Abbate
Protective effects of parecoxib, a cyclo-oxygenase-2 inhibitor, in postinfarction remodeling in the rat.
Journal of cardiovascular pharmacology 2007;50(5):571-7.
2007: Fadi Salloum; Anindita Das; Christopher S Thomas; Chang Yin; Rakesh C Kukreja
Adenosine A(1) receptor mediates delayed cardioprotective effect of sildenafil in mouse.
Journal of molecular and cellular cardiology 2007;43(5):545-51.
2007: Ramesh Natarajan; Fadi Salloum; Bernard J Fisher; Evan D Ownby; Rakesh C Kukreja; Alpha A Fowler
Activation of hypoxia-inducible factor-1 via prolyl-4 hydoxylase-2 gene silencing attenuates acute inflammatory responses in postischemic myocardium.
American journal of physiology. Heart and circulatory physiology 2007;293(3):H1571-80.
2007: Antonio Abbate; Fadi Salloum; Ramzi Ockaili; Alpha A Fowler; Giuseppe G L Biondi-Zoccai; Stefania Straino; Michael Lipinski; Alfonso Baldi; Filippo Crea; Luigi M Biasucci; George W Vetrovec; Rakesh C Kukreja
Improvement of cardiac function with parecoxib, a cyclo-oxygenase-2 inhibitor, in a rat model of ischemic heart failure.
Journal of cardiovascular pharmacology 2007;49(6):416-8.
2007: Rakesh C Kukreja
Cardiovascular protection with sildenafil following chronic inhibition of nitric oxide synthase.
British journal of pharmacology 2007;150(5):538-40.
2007: Rakesh C Kukreja; Lei Xi
eNOS phosphorylation: a pivotal molecular switch in vasodilation and cardioprotection?
Journal of molecular and cellular cardiology 2007;42(2):280-2.
2007: Fadi Salloum; Yuko Takenoshita; Ramzi Ockaili; Vladimir P Daoud; Eric Chou; Kazu-ichi Yoshida; Rakesh C Kukreja
Sildenafil and vardenafil but not nitroglycerin limit myocardial infarction through opening of mitochondrial K(ATP) channels when administered at reperfusion following ischemia in rabbits.
Journal of molecular and cellular cardiology 2007;42(2):453-8.
2006: Anindita Das; Albert Smolenski; Suzanne M Lohmann; Rakesh C Kukreja
Cyclic GMP-dependent protein kinase Ialpha attenuates necrosis and apoptosis following ischemia/reoxygenation in adult cardiomyocyte.
The Journal of biological chemistry 2006;281(50):38644-52.
2006: Rakesh C Kukreja
Mechanism of reactive oxygen species generation after opening of mitochondrial KATP channels.
American journal of physiology. Heart and circulatory physiology 2006;291(5):H2041-3.
2006: Lei Xi; Shobha Ghosh; Xiaoyin Wang; Anindita Das; Frank P Anderson; Rakesh C Kukreja
Hypercholesterolemia enhances tolerance to lethal systemic hypoxia in middle-aged mice: possible role of VEGF downregulation in brain.
Molecular and cellular biochemistry 2006;291(1-2):205-11.
2006: Shakil Khan; Fadi Salloum; Anindita Das; Lei Xi; George W Vetrovec; Rakesh C Kukreja
Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes.
Journal of molecular and cellular cardiology 2006;41(2):256-64.
2006: Fadi Salloum; Ramzi Ockaili; Michael Wittkamp; Vijay R Marwaha; Rakesh C Kukreja
Vardenafil: a novel type 5 phosphodiesterase inhibitor reduces myocardial infarct size following ischemia/reperfusion injury via opening of mitochondrial K(ATP) channels in rabbits.
Journal of molecular and cellular cardiology 2006;40(3):405-11.
2006: Rakesh C Kukreja
Synergistic effects of atorvastatin and sildenafil in cardioprotection--role of NO.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2006;20(1):5-8.
2006: Ramesh Natarajan; Fadi Salloum; Bernard J Fisher; Rakesh C Kukreja; Alpha A Fowler
Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury.
Circulation research 2006;98(1):133-40.
2006: Demet Tekin; Lei Xi; Rakesh C Kukreja
Genetic deletion of fas receptors or Fas ligands does not reduce infarct size after acute global ischemia-reperfusion in isolated mouse heart.
Cell biochemistry and biophysics 2006;44(1):111-7.
2005: Chang Yin; Lei Xi; Xiaoyin Wang; Mareen Eapen; Rakesh C Kukreja
Silencing heat shock factor 1 by small interfering RNA abrogates heat shock-induced cardioprotection against ischemia-reperfusion injury in mice.
Journal of molecular and cellular cardiology 2005;39(4):681-9.
2005: Ramzi Ockaili; Ramesh Natarajan; Fadi Salloum; Bernard J Fisher; Drew Jones; Alpha A Fowler; Rakesh C Kukreja
HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation.
American journal of physiology. Heart and circulatory physiology 2005;289(2):H542-8.
2005: Patrick W Fisher; Fadi Salloum; Anindita Das; Haroon Hyder; Rakesh C Kukreja
Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity.
Circulation 2005;111(13):1601-10.
2005: Rakesh C Kukreja; Fadi Salloum; Anindita Das; Ramzi Ockaili; Chang Yin; Yvonne A Bremer; Patrick W Fisher; Michael Wittkamp; John Hawkins; Eric Chou; Amit K Kukreja; Xiaoyin Wang; Vijay R Marwaha; Lei Xi
Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications.
Vascular pharmacology 2005;42(5-6):219-32.
2005: Anindita Das; Lei Xi; Rakesh C Kukreja
Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.
The Journal of biological chemistry 2005;280(13):12944-55.
2005: Yvonne A Bremer; Fadi Salloum; Ramzi Ockaili; Eric Chou; William B Moskowitz; Rakesh C Kukreja
Sildenafil citrate (viagra) induces cardioprotective effects after ischemia/reperfusion injury in infant rabbits.
Pediatric research 2005;57(1):22-7.
2004: Lei Xi; Mohiuddin Taher; Chang Yin; Fadi Salloum; Rakesh C Kukreja
Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1alpha and AP-1 and iNOS signaling.
American journal of physiology. Heart and circulatory physiology 2004;287(6):H2369-75.
2004: Xiaoyin Wang; Chang Yin; Lei Xi; Rakesh C Kukreja
Opening of Ca2+-activated K+ channels triggers early and delayed preconditioning against I/R injury independent of NOS in mice.
American journal of physiology. Heart and circulatory physiology 2004;287(5):H2070-7.
2004: Shinji Okubo; Yujirou Tanabe; Kenji Takeda; Michihiko Kitayama; Seiyu Kanemitsu; Rakesh C Kukreja; Noboru Takekoshi
Ischemic preconditioning and morphine attenuate myocardial apoptosis and infarction after ischemia-reperfusion in rabbits: role of delta-opioid receptor.
American journal of physiology. Heart and circulatory physiology 2004;287(4):H1786-91.
2004: Shinji Okubo; Yujirou Tanabe; Kenji Takeda; Michihiko Kitayama; Seiyu Kanemitsu; Rakesh C Kukreja; Noboru Takekoshi
Pretreatment with tyrosine kinase inhibitor attenuates the reduction of apoptosis 24 h after ischemic preconditioning.
The Japanese journal of physiology 2004;54(2):143-51.
2004: Anindita Das; Ramzi Ockaili; Fadi Salloum; Rakesh C Kukreja
Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits.
American journal of physiology. Heart and circulatory physiology 2004;286(4):H1455-60.
2004: Rakesh C Kukreja; Ramzi Ockaili; Fadi Salloum; Chang Yin; John Hawkins; Anindita Das; Lei Xi
Cardioprotection with phosphodiesterase-5 inhibition--a novel preconditioning strategy.
Journal of molecular and cellular cardiology 2004;36(2):165-73.
2003: Rakesh C Kukreja; Ramzi Ockaili; Fadi Salloum; Lei Xi
Sildenafil-induced cardioprotection in rabbits.
Cardiovascular research 2003;60(3):700-1; author reply 702-3.
2003: Ting C Zhao; Rakesh C Kukreja
Protein kinase C-delta mediates adenosine A3 receptor-induced delayed cardioprotection in mouse.
American journal of physiology. Heart and circulatory physiology 2003;285(1):H434-41.
2003: Fadi Salloum; Chang Yin; Lei Xi; Rakesh C Kukreja
Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart.
Circulation research 2003;92(6):595-7.
2002: Rakesh C Kukreja
NFkappaB activation during ischemia/reperfusion in heart: friend or foe?
Journal of molecular and cellular cardiology 2002;34(10):1301-4.
2002: Ramzi Ockaili; Fadi Salloum; John Hawkins; Rakesh C Kukreja
Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits.
American journal of physiology. Heart and circulatory physiology 2002;283(3):H1263-9.
2002: Lei Xi; Demet Tekin; Erdal Gursoy; Fadi Salloum; Joseph E Levasseur; Rakesh C Kukreja
Evidence that NOS2 acts as a trigger and mediator of late preconditioning induced by acute systemic hypoxia.
American journal of physiology. Heart and circulatory physiology 2002;283(1):H5-12.
2002: Ting C Zhao; Rakesh C Kukreja
Late preconditioning elicited by activation of adenosine A(3) receptor in heart: role of NF- kappa B, iNOS and mitochondrial K(ATP) channel.
Journal of molecular and cellular cardiology 2002;34(3):263-77.
2002: M Isabel Tejero-Taldo; Erdal Gursoy; Ting C Zhao; Rakesh C Kukreja
Alpha-adrenergic receptor stimulation produces late preconditioning through inducible nitric oxide synthase in mouse heart.
Journal of molecular and cellular cardiology 2002;34(2):185-95.
2001: Ting C Zhao; Mohiuddin M Taher; Kristoffer Valerie; Rakesh C Kukreja
p38 Triggers late preconditioning elicited by anisomycin in heart: involvement of NF-kappaB and iNOS.
Circulation research 2001;89(10):915-22.
2001: Lei Xi; Demet Tekin; P Bhargava; Rakesh C Kukreja
Whole body hyperthermia and preconditioning of the heart: basic concepts, complexity, and potential mechanisms.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2001;17(5):439-55.
2001: Demet Tekin; Lei Xi; T Zhao; M Isabel Tejero-Taldo; S Atluri; Rakesh C Kukreja
Mitogen-activated protein kinases mediate heat shock-induced delayed protection in mouse heart.
American journal of physiology. Heart and circulatory physiology 2001;281(2):H523-32.
2001: C Kositprapa; Ramzi Ockaili; Rakesh C Kukreja
Bradykinin B2 receptor is involved in the late phase of preconditioning in rabbit heart.
Journal of molecular and cellular cardiology 2001;33(7):1355-62.
2001: Ramzi Ockaili; P Bhargava; Rakesh C Kukreja
Chemical preconditioning with 3-nitropropionic acid in hearts: role of mitochondrial K(ATP) channel.
American journal of physiology. Heart and circulatory physiology 2001;280(5):H2406-11.
2001: Ting C Zhao; D S Hines; Rakesh C Kukreja
Adenosine-induced late preconditioning in mouse hearts: role of p38 MAP kinase and mitochondrial K(ATP) channels.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H1278-85.
2001: Shinji Okubo; O Wildner; M R Shah; JC Chelliah; Michael L Hess; Rakesh C Kukreja
Gene transfer of heat-shock protein 70 reduces infarct size in vivo after ischemia/reperfusion in the rabbit heart.
Circulation 2001;103(6):877-81.
2000: Lei Xi; Rakesh C Kukreja
Pivotal role of nitric oxide in delayed pharmacological preconditioning against myocardial infarction.
Toxicology 2000;155(1-3):37-44.
2000: Shinji Okubo; Nelson Bernardo; GT Elliott; Michael L Hess; Rakesh C Kukreja
Tyrosine kinase signaling in action potential shortening and expression of HSP72 in late preconditioning.
American journal of physiology. Heart and circulatory physiology 2000;279(5):H2269-76.
2000: T Zhao; Lei Xi; JC Chelliah; Joseph E Levasseur; Rakesh C Kukreja
Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice.
Circulation 2000;102(8):902-7.
1999: Ramzi Ockaili; V R Emani; Shinji Okubo; M Brown; K Krottapalli; Rakesh C Kukreja
Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide.
The American journal of physiology 1999;277(6 Pt 2):H2425-34.
1999: Lei Xi; Fadi Salloum; Demet Tekin; NC Jarrett; Rakesh C Kukreja
Glycolipid RC-552 induces delayed preconditioning-like effect via iNOS-dependent pathway in mice.
The American journal of physiology 1999;277(6 Pt 2):H2418-24.
1999: Nelson Bernardo; Shinji Okubo; M M Maaieh; M A Wood; Rakesh C Kukreja
Delayed preconditioning with adenosine is mediated by opening of ATP-sensitive K(+) channels in rabbit heart.
The American journal of physiology 1999;277(1 Pt 2):H128-35.
1999: Rakesh C Kukreja
Role of KATP channel in heat shock and pharmacological preconditioning.
Annals of the New York Academy of Sciences 1999;874():211-21.
1999: Shinji Okubo; Lei Xi; Nelson Bernardo; K Yoshida; Rakesh C Kukreja
Myocardial preconditioning: basic concepts and potential mechanisms.
Molecular and cellular biochemistry 1999;196(1-2):3-12.
1999: Rakesh C Kukreja; YZ Qian; Shinji Okubo; E E Flaherty
Role of protein kinase C and 72 kDa heat shock protein in ischemic tolerance following heat stress in the rat heart.
Molecular and cellular biochemistry 1999;195(1-2):123-31.
1999: Lei Xi; NC Jarrett; Michael L Hess; Rakesh C Kukreja
Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice.
Circulation 1999;99(16):2157-63.
1999: Nelson Bernardo; M D'Angelo; Shinji Okubo; A Joy; Rakesh C Kukreja
Delayed ischemic preconditioning is mediated by opening of ATP-sensitive potassium channels in the rabbit heart.
The American journal of physiology 1999;276(4 Pt 2):H1323-30.
1999: Lei Xi; NC Jarrett; Michael L Hess; Rakesh C Kukreja
Myocardial ischemia/reperfusion injury in the inducible nitric oxide synthase knockout mice.
Life sciences 1999;65(9):935-45.
1999: YZ Qian; Nelson Bernardo; MA Nayeem; JC Chelliah; Rakesh C Kukreja
Induction of 72-kDa heat shock protein does not produce second window of ischemic preconditioning in rat heart.
The American journal of physiology 1999;276(1 Pt 2):H224-34.
1998: R R Gill; C J Gbur; Bernard J Fisher; Michael L Hess; Alpha A Fowler; Rakesh C Kukreja; MM Sholley
Heat shock provides delayed protection against oxidative injury in cultured human umbilical vein endothelial cells.
Journal of molecular and cellular cardiology 1998;30(12):2739-49.
1998: Lei Xi; JC Chelliah; MA Nayeem; Joseph E Levasseur; Michael L Hess; Rakesh C Kukreja
Whole body heat shock fails to protect mouse heart against ischemia/reperfusion injury: role of 72 kDa heat shock protein and antioxidant enzymes.
Journal of molecular and cellular cardiology 1998;30(11):2213-27.
1998: Lei Xi; Michael L Hess; Rakesh C Kukreja
Ischemic preconditioning in isolated perfused mouse heart: reduction in infarct size without improvement of post-ischemic ventricular function.
Molecular and cellular biochemistry 1998;186(1-2):69-77.
1998: Y Janin; YZ Qian; Jeffrey B Hoag; GT Elliott; Rakesh C Kukreja
Pharmacologic preconditioning with monophosphoryl lipid A is abolished by 5-hydroxydecanoate, a specific inhibitor of the K(ATP) channel.
Journal of cardiovascular pharmacology 1998;32(3):337-42.
1998: YZ Qian; J B Shipley; Joseph E Levasseur; Rakesh C Kukreja
Dissociation of heat shock proteins expression with ischemic tolerance by whole body hyperthermia in rat heart.
Journal of molecular and cellular cardiology 1998;30(6):1163-72.
1997: Jeffrey B Hoag; YZ Qian; MA Nayeem; M D'Angelo; Rakesh C Kukreja
ATP-sensitive potassium channel mediates delayed ischemic protection by heat stress in rabbit heart.
The American journal of physiology 1997;273(5 Pt 2):H2458-64.
1997: MA Nayeem; GT Elliott; M R Shah; S L Hastillo-Hess; Rakesh C Kukreja
Monophosphoryl lipid A protects adult rat cardiac myocytes with induction of the 72-kD heat shock protein: a cellular model of pharmacologic preconditioning.
Journal of molecular and cellular cardiology 1997;29(8):2305-10.
1997: MA Nayeem; Michael L Hess; YZ Qian; Kathryn E Loesser; Rakesh C Kukreja
Delayed preconditioning of cultured adult rat cardiac myocytes: role of 70- and 90-kDa heat stress proteins.
The American journal of physiology 1997;273(2 Pt 2):H861-8.
1997: JE Schultz; YZ Qian; Garrett J Gross; Rakesh C Kukreja
The ischemia-selective KATP channel antagonist, 5-hydroxydecanoate, blocks ischemic preconditioning in the rat heart.
Journal of molecular and cellular cardiology 1997;29(3):1055-60.
1996: Rakesh C Kukreja; Michael C Kontos; Michael L Hess
Free radicals and heat shock protein in the heart.
Annals of the New York Academy of Sciences 1996;793():108-22.
1996: Michael C Kontos; J B Shipley; Rakesh C Kukreja
Heat stress improves functional recovery and induces synthesis of 27- and 70-kDa heat shock proteins without preserving sarcoplasmic reticulum function in the ischemic rat heart.
Journal of molecular and cellular cardiology 1996;28(9):1885-94.
1996: YZ Qian; Joseph E Levasseur; K Yoshida; Rakesh C Kukreja
KATP channels in rat heart: blockade of ischemic and acetylcholine-mediated preconditioning by glibenclamide.
The American journal of physiology 1996;271(1 Pt 2):H23-8.
1996: K Yoshida; M M Maaieh; J B Shipley; M Doloresco; Nelson Bernardo; YZ Qian; G T Elliott; Rakesh C Kukreja
Monophosphoryl lipid A induces pharmacologic 'preconditioning' in rabbit hearts without concomitant expression of 70-kDa heat shock protein.
Molecular and cellular biochemistry 1996;159(1):73-80.
1996: K Yoshida; M M Maaieh; J B Shipley; M Doloresco; Nelson Bernardo; YZ Qian; G T Elliott; Rakesh C Kukreja
Monophosphoryl lipid A induces pharmacologic 'preconditioning' in rabbit hearts without concomitant expression of 70-kDa heat shock protein.
Molecular and cellular biochemistry 1996;156(1):1-8.
1995: Michael L Hess; Rakesh C Kukreja
Free radicals, calcium homeostasis, heat shock proteins, and myocardial stunning.
The Annals of thoracic surgery 1995;60(3):760-6.
1995: S A Naseem; Michael C Kontos; P S Rao; Robert L Jesse; Michael L Hess; Rakesh C Kukreja
Sustained inhibition of nitric oxide by NG-nitro-L-arginine improves myocardial function following ischemia/reperfusion in isolated perfused rat heart.
Journal of molecular and cellular cardiology 1995;27(1):419-26.
1994: Rakesh C Kukreja; Michael C Kontos; K E Loesser; Surinder Batra; YZ Qian; C J Gbur; S A Naseem; Robert L Jesse; Michael L Hess
Oxidant stress increases heat shock protein 70 mRNA in isolated perfused rat heart.
The American journal of physiology 1994;267(6 Pt 2):H2213-9.
1994: Michael L Hess; Rakesh C Kukreja
Myocardial stunning.
Journal of cardiac surgery 1994;9(3 Suppl):382-6.
1993: Rakesh C Kukreja; Enoch P Wei; Hermes A Kontos; J N Bates
Nitric oxide and S-nitroso-L-cysteine as endothelium-derived relaxing factors from acetylcholine in cerebral vessels in cats.
Stroke; a journal of cerebral circulation 1993;24(12):2010-4; discussion 2014-5.
1993: Rakesh C Kukreja; K E Loesser; A A Kearns; S A Naseem; Michael L Hess
Protective effects of histidine during ischemia-reperfusion in isolated perfused rat hearts.
The American journal of physiology 1993;264(5 Pt 2):H1370-81.
1992: Enoch P Wei; Rakesh C Kukreja; Hermes A Kontos
Effects in cats of inhibition of nitric oxide synthesis on cerebral vasodilation and endothelium-derived relaxing factor from acetylcholine.
Stroke; a journal of cerebral circulation 1992;23(11):1623-8; discussion 1628-9.
1992: A K Vinnikova; Rakesh C Kukreja; M L Hess
Singlet oxygen-induced inhibition of cardiac sarcolemmal Na+K(+)-ATPase.
Journal of molecular and cellular cardiology 1992;24(5):465-70.
1992: Rakesh C Kukreja; Robert L Jesse; Michael L Hess
Singlet oxygen: a potential culprit in myocardial injury?
Molecular and cellular biochemistry 1992;111(1-2):17-24.
1991: K E Loesser; Rakesh C Kukreja; S Y Kazziha; Robert L Jesse; Michael L Hess
Oxidative damage to the myocardium: a fundamental mechanism of myocardial injury.
Cardioscience 1991;2(4):199-216.
1991: Rakesh C Kukreja; A A Kearns; Jay L Zweier; P Kuppusamy; M L Hess
Singlet oxygen interaction with Ca(2+)-ATPase of cardiac sarcoplasmic reticulum.
Circulation research 1991;69(4):1003-14.
1990: Rakesh C Kukreja; A B Weaver; Michael L Hess
Sarcolemmal Na(+)-K(+)-ATPase: inactivation by neutrophil-derived free radicals and oxidants.
The American journal of physiology 1990;259(5 Pt 2):H1330-6.
1990: Rakesh C Kukreja; Hermes A Kontos; Michael L Hess
Captopril and enalaprilat do not scavenge the superoxide anion.
The American journal of cardiology 1990;65(19):24I-27I.
1990: Hermes A Kontos; Enoch P Wei; Rakesh C Kukreja; Earl F Ellis; Michael L Hess
Differences in endothelium-dependent cerebral dilation by bradykinin and acetylcholine.
The American journal of physiology 1990;258(5 Pt 2):H1261-6.
1989: Hermes A Kontos; Enoch P Wei; John T Povlishock; Rakesh C Kukreja; Michael L Hess
Inhibition by arachidonate of cerebral arteriolar dilation from acetylcholine.
The American journal of physiology 1989;256(3 Pt 2):H665-71.
1989: Rakesh C Kukreja; A B Weaver; M L Hess
Stimulated human neutrophils damage cardiac sarcoplasmic reticulum function by generation of oxidants.
Biochimica et biophysica acta 1989;990(2):198-205.
1988: Rakesh C Kukreja; E Okabe; G M Schrier; Michael L Hess
Oxygen radical-mediated lipid peroxidation and inhibition of Ca2+-ATPase activity of cardiac sarcoplasmic reticulum.
Archives of biochemistry and biophysics 1988;261(2):447-57.