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Richard Kulmacz

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Procedures

Electron Spin Resonance Spectroscopy

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Sheep

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Anatomy

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Genes & Molecular Sequences

Amino Acid Sequence

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Co-Publications
Name
34
Tsai, Ah-Lim
17
Palmer, Graham
10
Wu, Gang
9
Liu, Wen
9
Ruan, Ke-He
8
Rogge, Corina
8
Tsai, A l
8
Wang, Lee-Ho
6
van der Donk, Wilfred
6
Wu, Kenneth
5
Kamensky, Yury
4
Bambai, Bijan
4
Smith, William
3
Okeley, Nicole
3
Chen, Weisan

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Publications

TOP 3
Rogge Corina E; Liu Wen; Kulmacz Richard J; Tsai Ah-Lim
Peroxide-induced radical formation at TYR385 and TYR504 in human PGHS-1.
Liu Wen; Rogge Corina E; da Silva Giordano F Z; Shinkarev Vladimir P; Tsai Ah-Lim; Kamensky Yury; Palmer Graham; Kulmacz Richard J
His92 and His110 selectively affect different heme centers of adrenal cytochrome b(561).
Rand Doyen J; Yucer Nur; Lichtenberger Lenard M; Kulmacz Richard J
Phospholipid actions on PGHS-1 and -2 cyclooxygenase kinetics.

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All Publications

2009: Rogge Corina E; Liu Wen; Kulmacz Richard J; Tsai Ah-Lim
Peroxide-induced radical formation at TYR385 and TYR504 in human PGHS-1.
Journal of inorganic biochemistry 2009;103(6):912-22.
2008: Liu Wen; Rogge Corina E; da Silva Giordano F Z; Shinkarev Vladimir P; Tsai Ah-Lim; Kamensky Yury; Palmer Graham; Kulmacz Richard J
His92 and His110 selectively affect different heme centers of adrenal cytochrome b(561).
Biochimica et biophysica acta 2008;1777(9):1218-28.
2008: Rand Doyen J; Yucer Nur; Lichtenberger Lenard M; Kulmacz Richard J
Phospholipid actions on PGHS-1 and -2 cyclooxygenase kinetics.
Prostaglandins & other lipid mediators 2008;85(3-4):134-43.
2007: Liu Wen; Rogge Corina E; Kamensky Yury; Tsai Ah-Lim; Kulmacz Richard J
Development of a bacterial system for high yield expression of fully functional adrenal cytochrome b561.
Protein expression and purification 2007;56(2):145-52.
2007: Kamensky Yury; Liu Wen; Tsai Ah-Lim; Kulmacz Richard J; Palmer Graham
Axial ligation and stoichiometry of heme centers in adrenal cytochrome b561.
Biochemistry 2007;46(29):8647-58.
2007: Poole Elizabeth M; Bigler Jeannette; Whitton John; Sibert Justin G; Kulmacz Richard J; Potter John D; Ulrich Cornelia M
Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps.
Carcinogenesis 2007;28(6):1259-63.
2007: Wu Gang; Rogge Corina E; Wang Jinn-Shyan; Kulmacz Richard J; Palmer Graham; Tsai Ah-Lim
Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation.
Biochemistry 2007;46(2):534-42.
2006: Liu Wen; Cao Dazhe; Oh Sungwhan F; Serhan Charles N; Kulmacz Richard J
Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1097-108.
2006: Liu W; Wang L-H; Fabian P; Hayashi Y; McGinley C M; van der Donk W A; Kulmacz R J
Arabidopsis thaliana fatty acid alpha-dioxygenase-1: evaluation of substrates, inhibitors and amino-terminal function.
Plant physiology and biochemistry : PPB / Société française de physiologie végétale 2006;44(5-6):284-93.
2006: Rogge Corina E; Ho Bryant; Liu Wen; Kulmacz Richard J; Tsai Ah-Lim
Role of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2.
Biochemistry 2006;45(2):523-32.
2005: Kulmacz Richard J
Regulation of cyclooxygenase catalysis by hydroperoxides.
Biochemical and biophysical research communications 2005;338(1):25-33.
2005: Liu Wen; Kamensky Yury; Kakkar Reva; Foley Erin; Kulmacz Richard J; Palmer Graham
Purification and characterization of bovine adrenal cytochrome b561 expressed in insect and yeast cell systems.
Protein expression and purification 2005;40(2):429-39.
2004: Liu Wen; Rogge Corina E; Bambai Bijan; Palmer Graham; Tsai Ah-Lim; Kulmacz Richard J
Characterization of the heme environment in Arabidopsis thaliana fatty acid alpha-dioxygenase-1.
The Journal of biological chemistry 2004;279(28):29805-15.
2004: Rogge Corina E; Liu Wen; Wu Gang; Wang Lee-Ho; Kulmacz Richard J; Tsai Ah-Lim
Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2.
Biochemistry 2004;43(6):1560-8.
2004: Bambai Bijan; Rogge Corina E; Stec Boguslaw; Kulmacz Richard J
Role of Asn-382 and Thr-383 in activation and inactivation of human prostaglandin H synthase cyclooxygenase catalysis.
The Journal of biological chemistry 2004;279(6):4084-92.
2003: Wu Gang; Kulmacz Richard J; Tsai Ah-Lim
Cyclooxygenase inactivation kinetics during reaction of prostaglandin H synthase-1 with peroxide.
Biochemistry 2003;42(46):13772-7.
2003: Kulmacz Richard J; van der Donk Wilfred A; Tsai Ah-Lim
Comparison of the properties of prostaglandin H synthase-1 and -2.
Progress in lipid research 2003;42(5):377-404.
2002: van der Donk Wilfred A; Tsai Ah-Lim; Kulmacz Richard J
The cyclooxygenase reaction mechanism.
Biochemistry 2002;41(52):15451-8.
2002: Kamensky Yury; Kulmacz Richard J; Palmer Graham
Composition of the heme centers in chromaffin granule cytochrome b(561).
Annals of the New York Academy of Sciences 2002;971():450-3.
2002: Tsai Ah-lim; Palmer Graham; Wu Gang; Peng Sheng; Okeley Nicole M; van der Donk Wilfred A; Kulmacz Richard J
Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2.
The Journal of biological chemistry 2002;277(41):38311-21.
2002: Peng Sheng; Okeley Nicole M; Tsai Ah-Lim; Wu Gang; Kulmacz Richard J; van der Donk Wilfred A
Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase.
Journal of the American Chemical Society 2002;124(36):10785-96.
2002: Wang Lee-Ho; Kulmacz Richard J
Thromboxane synthase: structure and function of protein and gene.
Prostaglandins & other lipid mediators 2002;68-69():409-22.
2001: Wu G; Vuletich J L; Kulmacz R J; Osawa Y; Tsai A L
Peroxidase self-inactivation in prostaglandin H synthase-1 pretreated with cyclooxygenase inhibitors or substituted with mangano protoporphyrin IX.
The Journal of biological chemistry 2001;276(23):19879-88.
2001: Peng S; Okeley N M; Tsai A L; Wu G; Kulmacz R J; van der Donk W A
Structural characterization of a pentadienyl radical intermediate formed during catalysis by prostaglandin H synthase-2.
Journal of the American Chemical Society 2001;123(15):3609-10.
2000: Guo Q; Kulmacz R J
Distinct influences of carboxyl terminal segment structure on function in the two isoforms of prostaglandin H synthase.
Archives of biochemistry and biophysics 2000;384(2):269-79.
2000: Lou B S; Snyder J K; Marshall P; Wang J S; Wu G; Kulmacz R J; Tsai A L; Wang J
Resonance Raman studies indicate a unique heme active site in prostaglandin H synthase.
Biochemistry 2000;39(40):12424-34.
2000: Bambai B; Kulmacz R J
Prostaglandin H synthase. Effects of peroxidase cosubstrates on cyclooxygenase velocity.
The Journal of biological chemistry 2000;275(36):27608-14.
2000: Tsai A; Kulmacz R J
Tyrosyl radicals in prostaglandin H synthase-1 and -2.
Prostaglandins & other lipid mediators 2000;62(3):231-54.
2000: Shi W; Hoganson C W; Espe M; Bender C J; Babcock G T; Palmer G; Kulmacz R J; Tsai A l
Electron paramagnetic resonance and electron nuclear double resonance spectroscopic identification and characterization of the tyrosyl radicals in prostaglandin H synthase 1.
Biochemistry 2000;39(14):4112-21.
1999: Tsai A l; Wu G; Palmer G; Bambai B; Koehn J A; Marshall P J; Kulmacz R J
Rapid kinetics of tyrosyl radical formation and heme redox state changes in prostaglandin H synthase-1 and -2.
The Journal of biological chemistry 1999;274(31):21695-700.
1999: Chen W; Pawelek T R; Kulmacz R J
Hydroperoxide dependence and cooperative cyclooxygenase kinetics in prostaglandin H synthase-1 and -2.
The Journal of biological chemistry 1999;274(29):20301-6.
1999: Lu G; Tsai A L; Van Wart H E; Kulmacz R J
Comparison of the peroxidase reaction kinetics of prostaglandin H synthase-1 and -2.
The Journal of biological chemistry 1999;274(23):16162-7.
1999: Wu G; Wei C; Kulmacz R J; Osawa Y; Tsai A L
A mechanistic study of self-inactivation of the peroxidase activity in prostaglandin H synthase-1.
The Journal of biological chemistry 1999;274(14):9231-7.
1999: Hsu P Y; Tsai A L; Kulmacz R J; Wang L H
Expression, purification, and spectroscopic characterization of human thromboxane synthase.
The Journal of biological chemistry 1999;274(2):762-9.
1999: Xiao G; Chen W; Kulmacz R J
Comparison of prostaglandin H synthase-1 and -2 structural stabilities.
Advances in experimental medicine and biology 1999;469():115-8.
1998: Tsai A L; Berka V; Kulmacz R J; Wu G; Palmer G
An improved sample packing device for rapid freeze-trap electron paramagnetic resonance spectroscopy kinetic measurements.
Analytical biochemistry 1998;264(2):165-71.
1998: Kulmacz R J
Cellular regulation of prostaglandin H synthase catalysis.
FEBS letters 1998;430(3):154-7.
1998: Xiao G; Chen W; Kulmacz R J
Comparison of structural stabilities of prostaglandin H synthase-1 and -2.
The Journal of biological chemistry 1998;273(12):6801-11.
1998: Tsai A l; Palmer G; Xiao G; Swinney D C; Kulmacz R J
Structural characterization of arachidonyl radicals formed by prostaglandin H synthase-2 and prostaglandin H synthase-1 reconstituted with mangano protoporphyrin IX.
The Journal of biological chemistry 1998;273(7):3888-94.
1997: Tsai A L; Wu G; Kulmacz R J
Stoichiometry of the interaction of prostaglandin H synthase with substrates.
Biochemistry 1997;36(42):13085-94.
1997: Guo Q; Chang S; Diekman L; Xiao G; Kulmacz R J
Comparison of prostaglandin H synthase isoform structures using limited proteolytic digestion.
Archives of biochemistry and biophysics 1997;344(1):150-8.
1997: Tsai A l; Wei C; Baek H K; Kulmacz R J; Van Wart H E
Comparison of peroxidase reaction mechanisms of prostaglandin H synthase-1 containing heme and mangano protoporphyrin IX.
The Journal of biological chemistry 1997;272(14):8885-94.
1997: Xiao G; Tsai A L; Palmer G; Boyar W C; Marshall P J; Kulmacz R J
Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2.
Biochemistry 1997;36(7):1836-45.
1997: Ren Y; Walker C; Ruan K H; Kulmacz R J
Examination of prostaglandin H synthase-1 topology in the endoplasmic reticulum membrane.
Advances in experimental medicine and biology 1997;400A():171-5.
1996: Wang L H; Matijevic-Aleksic N; Hsu P Y; Ruan K H; Wu K K; Kulmacz R J
Identification of thromboxane A2 synthase active site residues by molecular modeling-guided site-directed mutagenesis.
The Journal of biological chemistry 1996;271(33):19970-5.
1996: Guo Q; Wang L H; Ruan K H; Kulmacz R J
Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents.
The Journal of biological chemistry 1996;271(32):19134-9.
1995: Kulmacz R J; Wang L H
Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin H synthase-1 and -2.
The Journal of biological chemistry 1995;270(41):24019-23.
1995: Ren Y; Walker C; Loose-Mitchell D S; Deng J; Ruan K H; Kulmacz R J
Topology of prostaglandin H synthase-1 in the endoplasmic reticulum membrane.
Archives of biochemistry and biophysics 1995;323(1):205-14.
1995: Wei C; Kulmacz R J; Tsai A L
Comparison of branched-chain and tightly coupled reaction mechanisms for prostaglandin H synthase.
Biochemistry 1995;34(26):8499-512.
1995: Tsai A; Kulmacz R J; Palmer G
Spectroscopic evidence for reaction of prostaglandin H synthase-1 tyrosyl radical with arachidonic acid.
The Journal of biological chemistry 1995;270(18):10503-8.
1995: Ren Y; Loose-Mitchell D S; Kulmacz R J
Prostaglandin H synthase-1: evaluation of C-terminus function.
Archives of biochemistry and biophysics 1995;316(2):751-7.
1995: Ren Y; Ruan K H; Walker C; Kulmacz R J
Evaluation of prostaglandin H synthase-1 membrane topology and endoplasmic reticulum retention signals.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():113-5.
1994: Ruan K H; Milfeld K; Kulmacz R J; Wu K K
Comparison of the construction of a 3-D model for human thromboxane synthase using P450cam and BM-3 as templates: implications for the substrate binding pocket.
Protein engineering 1994;7(11):1345-51.
1994: Tsai A L; Wei C; Kulmacz R J
Interaction between nitric oxide and prostaglandin H synthase.
Archives of biochemistry and biophysics 1994;313(2):367-72.
1994: Ruan K H; Li P; Kulmacz R J; Wu K K
Characterization of the structure and membrane interaction of NH2-terminal domain of thromboxane A2 synthase.
The Journal of biological chemistry 1994;269(33):20938-42.
1994: Kulmacz R J; Palmer G; Wei C; Tsai A L
Reaction and free radical kinetics of prostaglandin H synthase with manganese protoporphyrin IX as the prosthetic group.
Biochemistry 1994;33(18):5428-39.
1994: Kulmacz R J; Pendleton R B; Lands W E
Interaction between peroxidase and cyclooxygenase activities in prostaglandin-endoperoxide synthase. Interpretation of reaction kinetics.
The Journal of biological chemistry 1994;269(8):5527-36.
1994: Tsai A; Hsi L C; Kulmacz R J; Palmer G; Smith W L
Characterization of the tyrosyl radicals in ovine prostaglandin H synthase-1 by isotope replacement and site-directed mutagenesis.
The Journal of biological chemistry 1994;269(7):5085-91.
1993: Ruan K H; Wang L H; Wu K K; Kulmacz R J
Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum.
The Journal of biological chemistry 1993;268(26):19483-90.
1993: Ruan K H; Kulmacz R J; Wilson A; Wu K K
Highly sensitive fluorimetric enzyme immunoassay for prostaglandin H synthase solubilized from cultured cells.
Journal of immunological methods 1993;162(1):23-30.
1993: Tsai A L; Kulmacz R J; Wang J S; Wang Y; Van Wart H E; Palmer G
Heme coordination of prostaglandin H synthase.
The Journal of biological chemistry 1993;268(12):8554-63.
1993: Kulmacz R J; Palmer G; Tsai A L
Substrate-induced free radicals in prostaglandin H synthase.
Journal of lipid mediators 1993;6(1-3):145-54.
1993: Hsi L C; Tsai A L; Kulmacz R J; English D G; Siefker A O; Otto J C; Smith W L
Trp387 and the putative leucine zippers of PGH synthases-1 and -2.
Journal of lipid mediators 1993;6(1-3):131-8.
1992: Tsai A L; Palmer G; Kulmacz R J
Prostaglandin H synthase. Kinetics of tyrosyl radical formation and of cyclooxygenase catalysis.
The Journal of biological chemistry 1992;267(25):17753-9.
1992: Zhang X; Tsai A L; Kulmacz R J
Chemical modification of prostaglandin H synthase with diethyl pyrocarbonate.
Biochemistry 1992;31(9):2528-38.
1992: Smith W L; Eling T E; Kulmacz R J; Marnett L J; Tsai A
Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase.
Biochemistry 1992;31(1):3-7.
1992: Ohashi K; Ruan K H; Kulmacz R J; Wu K K; Wang L H
Primary structure of human thromboxane synthase determined from the cDNA sequence.
The Journal of biological chemistry 1992;267(2):789-93.
1991: Kulmacz R J; Palmer G; Tsai A L
Prostaglandin H synthase: perturbation of the tyrosyl radical as a probe of anticyclooxygenase agents.
Molecular pharmacology 1991;40(5):833-7.
1991: Miller J F; Kulmacz R J; Lands W E
Use of a voltage-responsive timer to quantitate hydroperoxides by the cyclooxygenase activation assay.
Analytical biochemistry 1991;193(1):55-60.
1991: Kulmacz R J; Ren Y; Tsai A L; Palmer G
PGH synthase:interaction with hydroperoxides and indomethacin.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():137-40.
1990: Shimokawa T; Kulmacz R J; DeWitt D L; Smith W L
Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis.
The Journal of biological chemistry 1990;265(33):20073-6.
1990: Kulmacz R J; Ren Y; Tsai A L; Palmer G
Prostaglandin H synthase: spectroscopic studies of the interaction with hydroperoxides and with indomethacin.
Biochemistry 1990;29(37):8760-71.
1990: Kulmacz R J; Miller J F; Pendleton R B; Lands W E
Cyclooxygenase initiation assay for hydroperoxides.
Methods in enzymology 1990;186():431-8.
1989: Kulmacz R J
Concerted loss of cyclooxygenase and peroxidase activities from prostaglandin H synthase upon proteolytic attack.
Prostaglandins 1989;38(3):277-88.
1989: Kulmacz R J
Topography of prostaglandin H synthase. Antiinflammatory agents and the protease-sensitive arginine 253 region.
The Journal of biological chemistry 1989;264(24):14136-44.
1989: Kulmacz R J; Wu K K
Topographic studies of microsomal and pure prostaglandin H synthase.
Archives of biochemistry and biophysics 1989;268(2):502-15.
1988: Marshall P J; Kulmacz R J
Prostaglandin H synthase: distinct binding sites for cyclooxygenase and peroxidase substrates.
Archives of biochemistry and biophysics 1988;266(1):162-70.
1987: Kulmacz R J
Attachment of substrate metabolite to prostaglandin H synthase upon reaction with arachidonic acid.
Biochemical and biophysical research communications 1987;148(2):539-45.
1987: Kulmacz R J
Prostaglandin G2 levels during reaction of prostaglandin H synthase with arachidonic acid.
Prostaglandins 1987;34(2):225-40.
1987: Kulmacz R J; Tsai A L; Palmer G
Heme spin states and peroxide-induced radical species in prostaglandin H synthase.
The Journal of biological chemistry 1987;262(22):10524-31.
1987: Marshall P J; Kulmacz R J; Lands W E
Constraints on prostaglandin biosynthesis in tissues.
The Journal of biological chemistry 1987;262(8):3510-7.
1985: Lands W E; Marshall P J; Kulmacz R J
Hydroperoxide availability in the regulation of the arachidonate cascade.
Advances in prostaglandin, thromboxane, and leukotriene research 1985;15():233-5.

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