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Hiromitsu Kumada

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Norio Akuta; Yasuji Arase; Tasuku Hara; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Emergence of telaprevir-resistant variants detected by ultra-deep sequencing after triple therapy in patients infected with HCV genotype 1.
Norihiro Imai; Yusuke Kawamura; Masahiro Kobayashi; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Satoshi Saitoh; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Transcatheter arterial chemotherapy with miriplatin for hepatocellular carcinoma patients with chronic renal failure: report of three cases.
Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Hiromitsu Kumada; Satoshi Saito; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Tetsuro Kobayashi
Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C.

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2013: Norio Akuta; Yasuji Arase; Tasuku Hara; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Emergence of telaprevir-resistant variants detected by ultra-deep sequencing after triple therapy in patients infected with HCV genotype 1.
Journal of medical virology 2013;85(6):1028-36.
2013: Norihiro Imai; Yusuke Kawamura; Masahiro Kobayashi; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Satoshi Saitoh; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Transcatheter arterial chemotherapy with miriplatin for hepatocellular carcinoma patients with chronic renal failure: report of three cases.
Gut and liver 2013;7(2):246-51.
2013: Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Hiromitsu Kumada; Satoshi Saito; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Tetsuro Kobayashi
Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C.
Hepatology (Baltimore, Md.) 2013;57(3):964-73.
2013: Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Efficacy and anticarcinogenic activity of ribavirin combination therapy for hepatitis C virus-related compensated cirrhosis.
Intervirology 2013;56(1):37-45.
2013: Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Hiromitsu Kumada
Amino acid substitutions in the hepatitis C Virus core region and lipid metabolism are associated with hepatocarcinogenesis in nonresponders to interferon plus ribavirin combination therapy.
Intervirology 2013;56(1):13-21.
2012: Norio Akuta; Yasuji Arase; Tasuku Hara; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Complicated relationships of amino acid substitution in hepatitis C virus core region and IL28B genotype influencing hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 2012;56(6):2134-41.
2012: Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Association of IL28B genotype and viral response of hepatitis C virus genotype 2 to interferon plus ribavirin combination therapy.
Journal of medical virology 2012;84(10):1593-9.
2012: Yasuji Arase; Miharu Hirakawa; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Naoki Matsumoto; Satoshi Saito; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Hiromitsu Kumada
Efficacy of reduction therapy of natural human β-interferon and ribavirin in elderly patients with chronic hepatitis C, genotype 1b and high viral load.
Hepatology research : the official journal of the Japan Society of Hepatology 2012;42(10):949-57.
2012: Atsushi Ono; Satoshi Saitou; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Sachiyo Watahiki; Rie Mineta; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Hiromitsu Kumada
Long-term continuous entecavir therapy in nucleos(t)ide-naïve chronic hepatitis B patients.
Journal of hepatology 2012;57(3):508-14.
2012: Nami Mori; Satoshi Saito; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Mariko Kobayashi; Masahiro Kobayashi; Hiromitsu Kumada
Determinants of the clinical outcome of patients with severe acute exacerbation of chronic hepatitis B virus infection.
Journal of gastroenterology 2012;47(9):1022-9.
2012: Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Norihiro Imai; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Naoki Matsumoto; Satoshi Saito; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Hiromitsu Kumada
Efficacy of reduction therapy of natural human β-interferon and ribavirin in elderly patients with chronic hepatitis C, genotype 2 and high virus load.
Hepatology research : the official journal of the Japan Society of Hepatology 2012;42(8):750-6.
2012: Makiko Takeyasu; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Hiromitsu Kumada
Long-term interferon monotherapy reduces the risk of HCV-associated hepatocellular carcinoma.
Journal of medical virology 2012;84(8):1199-207.
2012: Fumitaka Suzuki; Yoshiyuki Suzuki; Sachiyo Watahiki; Rie Mineta; Yuzo Miyakawa; Satoshi Saito; Yuya Seko; Hitomi Sezaki; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Hiromitsu Kumada
Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2012;54(4):352-4.
2012: Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Determinants of response to triple therapy of telaprevir, peginterferon, and ribavirin in previous non-responders infected with HCV genotype 1.
Journal of medical virology 2012;84(7):1097-105.
2012: Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saito; Yuya Seko; Hitomi Sezaki; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Mariko Kobayashi; Masahiro Kobayashi; Hiromitsu Kumada
Long-term efficacy of interferon therapy in patients with chronic hepatitis B virus infection in Japan.
Journal of gastroenterology 2012;47(7):814-22.
2012: Naoki Matsumoto; Satoshi Saito; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada; Kaoru Aida; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Norihiro Imai; Yusuke Kawamura; Mariko Kobayashi; Masahiro Kobayashi; Tetsuro Kobayashi
Prevalence and predictive factors of diabetes in hepatitis virus positive liver cirrhosis with fasting plasma glucose level of <126 mg/dL.
Hepatology research : the official journal of the Japan Society of Hepatology 2012;42(6):558-63.
2012: Mariko Kobayashi; Norio Akuta; Yasuji Arase; Kazuaki Chayama; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Yuzo Miyakawa; Satoshi Saitoh; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Association of two polymorphisms of the IL28B gene with viral factors and treatment response in 1,518 patients infected with hepatitis C virus.
Journal of gastroenterology 2012;47(5):596-605.
2012: Norihiro Imai; Yusuke Kawamura; Masahiro Kobayashi; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Satoshi Saitoh; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Transcatheter arterial chemotherapy using miriplatin-lipiodol suspension with or without embolization for unresectable hepatocellular carcinoma.
Japanese journal of clinical oncology 2012;42(3):175-82.
2012: Yasuji Arase; Tetsuya Hosaka; Shiun Dong Hsieh; Kenji Ikeda; Norihiro Imai; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Hiromitsu Kumada; Naoki Matsumoto; Kyoko Ogawa; Yuki Ohmoto; Satoshi Saito; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Maho Tanabe; Hiroshi Tsuji; Norio Akuta; Kazuhisa Amakawa; Tetsuro Kobayashi
Difference in malignancies of chronic liver disease due to non-alcoholic fatty liver disease or hepatitis C in Japanese elderly patients.
Hepatology research : the official journal of the Japan Society of Hepatology 2012;42(3):264-72.
2012: Yusuke Kawamura; Masahiro Kobayashi; Norio Akuta; Kazuhisa Amakawa; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Norihiro Imai; Yuki Ohmoto; Satoshi Saitoh; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiroshi Tsuji; Hiromitsu Kumada
Large-scale long-term follow-up study of Japanese patients with non-alcoholic Fatty liver disease for the onset of hepatocellular carcinoma.
The American journal of gastroenterology 2012;107(2):253-61.
2012: Norio Akuta; Yasuji Arase; Kazuaki Chayama; Miharu Hirakawa; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Yusuke Nakamura; Satoshi Saitoh; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy.
Intervirology 2012;55(3):231-41.
2012: Norio Akuta; Yasuji Arase; Kazuaki Chayama; Miharu Hirakawa; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Mariko Kobayashi; Yusuke Nakamura; Satoshi Saitoh; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromi Yatsuji; Hiromitsu Kumada
Amino acid substitution in HCV core region and genetic variation near the IL28B gene affect viral dynamics during telaprevir, peginterferon and ribavirin treatment.
Intervirology 2012;55(6):417-25.
2011: Norihiro Imai; Yusuke Kawamura; Masahiro Kobayashi; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Naoki Matsumoto; Satoshi Saitoh; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
[Transcatheter arterial chemotherapy with miriplatin for patients with hepatocellular carcinoma and chronic renal failure].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2011;108(11):1872-8.
2011: Masahiro Kobayashi; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Yusuke Kawamura; Satoshi Saitoh; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Highly sensitive AFP-L3% assay is useful for predicting recurrence of hepatocellular carcinoma after curative treatment pre- and postoperatively.
Hepatology research : the official journal of the Japan Society of Hepatology 2011;41(11):1036-45.
2011: Yusuke Kawamura; Masahiro Kobayashi; Tetsuya Hosaka; Kenji Ikeda; Satoshi Saitoh; Yuya Seko; Hiromitsu Kumada
Heterogeneous type 4 enhancement of hepatocellular carcinoma on dynamic CT is associated with tumor recurrence after radiofrequency ablation.
AJR. American journal of roentgenology 2011;197(4):W665-73.
2011: Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Norihiro Imai; Yusuke Kawamura; Mariko Kobayashi; Masahiro Kobayashi; Naoki Matsumoto; Kyoko Ogawa; Satoshi Saito; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Hiromitsu Kumada
Development rate of chronic kidney disease in hepatitis C virus patients with advanced fibrosis after interferon therapy.
Hepatology research : the official journal of the Japan Society of Hepatology 2011;41(10):946-54.
2011: Norio Akuta; Fumitaka Suzuki; Miharu Hirakawa; Yusuke Kawamura; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Amino acid substitutions in hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by antiviral therapy.
Journal of medical virology 2011;83(6):1016-22.
2011: Yasuji Arase; Fumitaka Suzuki; Masahiro Kobayashi; Yoshiyuki Suzuki; Yusuke Kawamura; Naoki Matsumoto; Norio Akuta; Norihisa Imai; Mariko Kobayashi; Hitomi Sezaki; Satoshi Saito; Tetsuya Hosaka; Kenji Ikeda; Hiromitsu Kumada; Yuki Ohmoto; Kazuhisa Amakawa; Hiroshi Tsuji; Shiun Dong Hsieh; Tetsurou Kobayashi
Efficacy and safety in sitagliptin therapy for diabetes complicated by chronic liver disease caused by hepatitis C virus.
Hepatology research : the official journal of the Japan Society of Hepatology 2011;41(6):524-9.
2011: Yasuji Arase; Hiromitsu Kumada
[Treatment strategy for chronic hepatitis B in Japan].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 4():475-9.
2011: Yasuji Arase; Hiromitsu Kumada
[Treatment strategy for chronic hepatitis C in Japan].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 4():180-4.
2011: Kenji Ikeda; Masahiro Kobayashi; Yusuke Kawamura; Norihiro Imai; Yuya Seko; Miharu Hirakawa; Tetsuya Hosaka; Hitomi Sezaki; Norio Akuta; Satoshi Saitoh; Fumitaka Suzuki; Yoshiyuki Suzuki; Yasuji Arase; Hiromitsu Kumada
Stage progression of small hepatocellular carcinoma after radical therapy: comparisons of radiofrequency ablation and surgery using the Markov model.
Liver international : official journal of the International Association for the Study of the Liver 2011;31(5):692-9.
2011: Tetsuya Hosaka; Fumitaka Suzuki; Hiromitsu Kumada
[Efficacy and treatment strategy for drug resistances of nucleos(t)ide analogues for chronic hepatitis B].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2011;108(2):210-4.
2011: Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Hitomi Sezaki; Miharu Hirakawa; Yusuke Kawamura; Tetsuya Hosaka; Masahiro Kobayashi; Satoshi Saito; Yasuji Arase; Kenji Ikeda; Mariko Kobayashi; Kazuaki Chayama; Naoyuki Kamatani; Yusuke Nakamura; Yuzo Miyakawa; Hiromitsu Kumada
Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir.
Hepatology (Baltimore, Md.) 2011;53(2):415-21.
2011: Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Norihiro Imai; Yusuke Kawamura; Mariko Kobayashi; Masahiro Kobayashi; Naoki Matsumoto; Satoshi Saito; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Hiromitsu Kumada
Efficacy and safety of combination therapy of natural human interferon beta and ribavirin in chronic hepatitis C patients.
Internal medicine (Tokyo, Japan) 2011;50(19):2083-8.
2011: Norihiro Imai; Yusuke Kawamura; Masahiro Kobayashi; Norio Akuta; Yasuji Arase; Tetsuya Hosaka; Kenji Ikeda; Satoshi Saitoh; Yuya Seko; Hitomi Sezaki; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Previous chemoembolization response after transcatheter arterial chemoembolization (TACE) can predict the anti-tumor effect of subsequent TACE with miriplatin in patients with recurrent hepatocellular carcinoma.
Oncology 2011;80(3-4):188-94.
2011: Yasuji Arase; Fumitaka Suzuki; Masahiro Kobayashi; Yoshiyuki Suzuki; Yusuke Kawamura; Naoki Matsumoto; Norio Akuta; Mariko Kobayashi; Hitomi Sezaki; Satoshi Saito; Tetsuya Hosaka; Kenji Ikeda; Hiromitsu Kumada; Yuki Ohmoto; Kazuhisa Amakawa; Hiroshi Tsuji; Shiun Dong Hsieh; Kazuhisa Kato; Maho Tanabe; Kyoko Ogawa; Shigeko Hara; Tetsuro Kobayashi
The development of chronic kidney disease in Japanese patients with non-alcoholic fatty liver disease.
Internal medicine (Tokyo, Japan) 2011;50(10):1081-7.
2010: Kenji Ikeda; Masahiro Kobayashi; Yuya Seko; Norihiro Imai; Miharu Hirakawa; Yusuke Kawamura; Hitomi Sezaki; Tetsuya Hosaka; Norio Akuta; Satoshi Saitoh; Fumitaka Suzuki; Yoshiyuki Suzuki; Yasuji Arase; Hiromitsu Kumada
Administration of interferon for two or more years decreases early stage hepatocellular carcinoma recurrence rate after radical ablation: A retrospective study of hepatitis C virus-related liver cancer.
Hepatology research : the official journal of the Japan Society of Hepatology 2010;40(12):1168-75.
2010: Tetsuya Hosaka; Fumitaka Suzuki; Masahiro Kobayashi; Miharu Hirakawa; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Norio Akuta; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Mariko Kobayashi; Hiromitsu Kumada
HBcrAg is a predictor of post-treatment recurrence of hepatocellular carcinoma during antiviral therapy.
Liver international : official journal of the International Association for the Study of the Liver 2010;30(10):1461-70.
2010: Yusuke Kawamura; Kenji Ikeda; Miharu Hirakawa; Hiromi Yatsuji; Hitomi Sezaki; Tetsuya Hosaka; Norio Akuta; Masahiro Kobayashi; Satoshi Saitoh; Fumitaka Suzuki; Yoshiyuki Suzuki; Yasuji Arase; Hiromitsu Kumada
New classification of dynamic computed tomography images predictive of malignant characteristics of hepatocellular carcinoma.
Hepatology research : the official journal of the Japan Society of Hepatology 2010;40(10):1006-14.
2010: Norio Akuta; Fumitaka Suzuki; Miharu Hirakawa; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Kazuaki Chayama; Yusuke Nakamura; Hiromitsu Kumada
Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin.
Hepatology (Baltimore, Md.) 2010;52(2):421-9.
2010: Yoshiyuki Suzuki; Kenji Ikeda; Miharu Hirakawa; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Tetsuya Hosaka; Norio Akuta; Masahiro Kobayashi; Fumitaka Suzuki; Satoshi Saitoh; Yasuji Arase; Mariko Kobayashi; Yuzo Miyakawa; Hiromitsu Kumada
Association of HLA-DR14 with the treatment response in Japanese patients with autoimmune hepatitis.
Digestive diseases and sciences 2010;55(7):2070-6.
2010: Fumitaka Suzuki; Norio Akuta; Yoshiyuki Suzuki; Hiromi Yatsuji; Hitomi Sezaki; Yasuji Arase; Miharu Hirakawa; Yusuke Kawamura; Tetsuya Hosaka; Masahiro Kobayashi; Satoshi Saitoh; Kenji Ikeda; Mariko Kobayashi; Sachiyo Watahiki; Hiromitsu Kumada
Efficacy of switching to entecavir monotherapy in Japanese lamivudine-pretreated patients.
Journal of gastroenterology and hepatology 2010;25(5):892-8.
2010: Norio Akuta; Fumitaka Suzuki; Miharu Hirakawa; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Amino acid substitutions in the hepatitis C virus core region of genotype 1b affect very early viral dynamics during treatment with telaprevir, peginterferon, and ribavirin.
Journal of medical virology 2010;82(4):575-82.
2010: Yoshimasa Hashimoto; Fumitaka Suzuki; Miharu Hirakawa; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Tetuya Hosaka; Norio Akuta; Masahiro Kobayashi; Satoshi Saito; Yoshiyuki Suzuki; Mariko Kobayashi; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Clinical and virological effects of long-term (over 5 years) lamivudine therapy.
Journal of medical virology 2010;82(4):684-91.
2010: Yusuke Kawamura; Kenji Ikeda; Hiromitsu Kumada
[Strategy for advanced hepatocellular carcinoma unresponsive to transcatheter arterial chemoembolization using epirubicin].
Gan to kagaku ryoho. Cancer & chemotherapy 2010;37(3):402-7.
2010: Yasuji Arase; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Masahiro Kobayashi; Hitomi Sezaki; Tetsuya Hosaka; Yusuke Kawamura; Hiromi Yatsuji; Miharu Hirakawa; Kenji Ikeda; Shiun Dong Hsieh; Yuki Oomoto; Kazuhisa Amakawa; Hisahito Kato; Tamae Kazawa; Hiroshi Tsuji; Tetsuro Kobayashi; Hiromitsu Kumada
Virus clearance reduces bone fracture in postmenopausal women with osteoporosis and chronic liver disease caused by hepatitis C virus.
Journal of medical virology 2010;82(3):390-5.
2010: Mariko Kobayashi; Fumitaka Suzuki; Norio Akuta; Hiromi Yatsuji; Tetsuya Hosaka; Hitomi Sezaki; Masahiro Kobayashi; Yusuke Kawamura; Yoshiyuki Suzuki; Yasuji Arase; Kenji Ikeda; Rie Mineta; Satomi Iwasaki; Sachiyo Watahiki; Hiromitsu Kumada
Correlation of YMDD mutation and breakthrough hepatitis with hepatitis B virus DNA and serum ALT during lamivudine treatment.
Hepatology research : the official journal of the Japan Society of Hepatology 2010;40(2):125-34.
2010: Tetsuya Hosaka; Fumitaka Suzuki; Masahiro Kobayashi; Miharu Hirakawa; Yusuke Kawamura; Hiromi Yastuji; Hitomi Sezaki; Norio Akuta; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Yuzo Miyakawa; Hiromitsu Kumada
Development of HCC in patients receiving adefovir dipivoxil for lamivudine-resistant hepatitis B virus mutants.
Hepatology research : the official journal of the Japan Society of Hepatology 2010;40(2):145-52.
2010: Yasuji Arase; Fumitaka Suzuki; Norio Akuta; Hitomi Sezaki; Yoshiyuki Suzuki; Yusuke Kawamura; Masahiro Kobayashi; Tetsuya Hosaka; Hiromi Yatsuji; Miharu Hirakawa; Naoki Matsumoto; Satoshi Saito; Kenji Ikeda; Mariko Kobayashi; Hiromitsu Kumada
Efficacy and safety of combination therapy of natural human interferon beta and ribavirin in chronic hepatitis C patients with genotype 2 and high virus load.
Internal medicine (Tokyo, Japan) 2010;49(11):965-70.
2010: Yasuji Arase; Fumitaka Suzuki; Norio Akuta; Hitomi Sezaki; Yoshiyuki Suzuki; Yusuke Kawamura; Masahiro Kobayashi; Tetsuya Hosaka; Hiromi Yatsuji; Miharu Hirakawa; Satoshi Saito; Kenji Ikeda; Mariko Kobayashi; Hiromitsu Kumada
Efficacy and safety of combination therapy of natural human interferon beta and ribavirin in chronic hepatitis C patients with genotype 1b and high virus load.
Internal medicine (Tokyo, Japan) 2010;49(11):957-63.
2010: Norio Akuta; Fumitaka Suzuki; Yasuji Arase; Miharu Hirakawa; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Kenji Ikeda; Hiromitsu Kumada
Extending combination therapy with peginterferon plus ribavirin for genotype 2 chronic hepatitis C virological responders: a pilot study of 7 cases.
Intervirology 2010;53(3):188-92.
2010: Hiromitsu Kumada; Hisataka Moriwaki; Hideyuki Nomura; Takeshi Okanoue; Makoto Oketani; Morikazu Onji; Shotaro Sakisaka; Masataka Seike; Fumitaka Suzuki; Tetsuo Takehara; Eiji Tanaka; Joji Toyota; Yoshiyuki Ueno; Kentaro Yoshioka; Hiroshi Yotsuyanagi; Kazuaki Chayama; Namiki Izumi
Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan.
Hepatology research : the official journal of the Japan Society of Hepatology 2010;40(1):8-13.
2010: Hiromitsu Kumada; Hisataka Moriwaki; Hideyuki Nomura; Takeshi Okanoue; Makoto Oketani; Morikazu Onji; Shotaro Sakisaka; Masataka Seike; Fumitaka Suzuki; Tetsuo Takehara; Eiji Tanaka; Joji Toyota; Yoshiyuki Ueno; Kentaro Yoshioka; Hiroshi Yotsuyanagi; Kazuaki Chayama; Namiki Izumi
Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan.
Hepatology research : the official journal of the Japan Society of Hepatology 2010;40(1):1-7.
2010: Mariko Kobayashi; Norio Akuta; Fumitaka Suzuki; Tetsuya Hosaka; Hitomi Sezaki; Masahiro Kobayashi; Yoshiyuki Suzuki; Yasuji Arase; Kenji Ikeda; Sachiyo Watahiki; Rie Mineta; Satomi Iwasaki; Yuzo Miyakawa; Hiromitsu Kumada
Influence of amino-acid polymorphism in the core protein on progression of liver disease in patients infected with hepatitis C virus genotype 1b.
Journal of medical virology 2010;82(1):41-8.
2010: Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Hitomi Sezaki; Hiromi Yatsuji; Yasuji Arase; Miharu Hirakawa; Yusuke Kawamura; Tetsuya Hosaka; Masahiro Kobayashi; Satoshi Saito; Kenji Ikeda; Mariko Kobayashi; Sachiyo Watahiki; Rie Mineta; Satomi Iwasaki; Hiromitsu Kumada
Sustained virological response in a patient with chronic hepatitis C treated by monotherapy with the NS3-4A protease inhibitor telaprevir.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2010;47(1):76-8.
2009: Fumitaka Suzuki; Norio Akuta; Yoshiyuki Suzuki; Hitomi Sezaki; Hiromi Yatsuji; Yusuke Kawamura; Tetsuya Hosaka; Masahiro Kobayashi; Yasuji Arase; Kenji Ikeda; Rie Mineta; Satomi Iwasaki; Sachiyo Watahiki; Mariko Kobayashi; Yuzo Miyakawa; Hiromitsu Kumada
Rapid loss of hepatitis C virus genotype 1b from serum in patients receiving a triple treatment with telaprevir (MP-424), pegylated interferon and ribavirin for 12 weeks.
Hepatology research : the official journal of the Japan Society of Hepatology 2009;39(11):1056-63.
2009: Yasuji Arase; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Masahiro Kobayashi; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Tetsuya Hosaka; Miharu Hirakawa; Satoshi Saito; Kenji Ikeda; Mariko Kobayashi; Hiromitsu Kumada; Tetsuro Kobayashi
Losartan reduces the onset of type 2 diabetes in hypertensive Japanese patients with chronic hepatitis C.
Journal of medical virology 2009;81(9):1584-90.
2009: Norio Akuta; Fumitaka Suzuki; Miharu Hirakawa; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus.
Journal of medical virology 2009;81(6):1032-9.
2009: Kenji Ikeda; Masahiro Kobayashi; Takashi Someya; Satoshi Saitoh; Tetsuya Hosaka; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Yasuji Arase; Hiromitsu Kumada
Occult hepatitis B virus infection increases hepatocellular carcinogenesis by eight times in patients with non-B, non-C liver cirrhosis: a cohort study.
Journal of viral hepatitis 2009;16(6):437-43.
2009: Hitomi Sezaki; Fumitaka Suzuki; Yusuke Kawamura; Hiromi Yatsuji; Tetsuya Hosaka; Norio Akuta; Masahiro Kobayashi; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Yuzo Miyakawa; Hiromitsu Kumada
Poor response to pegylated interferon and ribavirin in older women infected with hepatitis C virus of genotype 1b in high viral loads.
Digestive diseases and sciences 2009;54(6):1317-24.
2009: Kenji Ikeda; Yasuji Arase; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Tetsuya Hosaka; Norio Akuta; Masahiro Kobayashi; Satoshi Saitoh; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Necessities of interferon therapy in elderly patients with chronic hepatitis C.
The American journal of medicine 2009;122(5):479-86.
2009: Tetsuya Hosaka; Kenji Ikeda; Masahiro Kobayashi; Miharu Hirakawa; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Hiromitsu Kumada
Predictive factors of advanced recurrence after curative resection of small hepatocellular carcinoma.
Liver international : official journal of the International Association for the Study of the Liver 2009;29(5):736-42.
2009: Yusuke Kawamura; Kenji Ikeda; Miharu Hirakawa; Tetsuya Hosaka; Masahiro Kobayashi; Satoshi Saitoh; Hiromi Yatsuji; Hitomi Sezaki; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Yasuji Arase; Hiromitsu Kumada
Efficacy of platinum analogue for advanced hepatocellular carcinoma unresponsive to transcatheter arterial chemoembolization with epirubicin.
Hepatology research : the official journal of the Japan Society of Hepatology 2009;39(4):346-54.
2009: Yoshiyuki Suzuki; Fumitaka Suzuki; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Tetsuya Hosaka; Norio Akuta; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Mariko Kobayashi; Yuzo Miyakawa; Hiromitsu Kumada
Efficacy of entecavir treatment for lamivudine-resistant hepatitis B over 3 years: histological improvement or entecavir resistance?
Journal of gastroenterology and hepatology 2009;24(3):429-35.
2009: Norio Akuta; Fumitaka Suzuki; Miharu Hirakawa; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
A matched case-controlled study of 48 and 72 weeks of peginterferon plus ribavirin combination therapy in patients infected with HCV genotype 1b in Japan: amino acid substitutions in HCV core region as predictor of sustained virological response.
Journal of medical virology 2009;81(3):452-8.
2009: Yasuji Arase; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Masahiro Kobayashi; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Tetsuya Hosaka; Miharu Hirakawa; Kenji Ikeda; Hiromitsu Kumada
Sustained virological response reduces incidence of onset of type 2 diabetes in chronic hepatitis C.
Hepatology (Baltimore, Md.) 2009;49(3):739-44.
2009: Masahiro Kobayashi; Kenji Ikeda; Yusuke Kawamura; Hiromi Yatsuji; Tetsuya Hosaka; Hitomi Sezaki; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Hiromitsu Kumada
High serum des-gamma-carboxy prothrombin level predicts poor prognosis after radiofrequency ablation of hepatocellular carcinoma.
Cancer 2009;115(3):571-80.
2009: Norio Akuta; Fumitaka Suzuki; Miharu Hirakawa; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Masahiro Kobayashi; Mariko Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 2a high viral load and virological response to interferon-ribavirin combination therapy.
Intervirology 2009;52(6):301-9.
2009: Yasuji Arase; Fumitaka Suzuki; Hitomi Sezaki; Yusuke Kawamura; Yoshiyuki Suzuki; Masahiro Kobayashi; Norio Akuta; Tetsuya Hosaka; Hiromi Yatsuji; Miharu Hirakawa; Mariko Kobayashi; Satoshi Saitoh; Kenji Ikeda; Hiromitsu Kumada
The efficacy of interferon-beta monotherapy for elderly patients with type C hepatitis of genotype 2.
Internal medicine (Tokyo, Japan) 2009;48(16):1337-42.
2009: Suguru Ogura; Norio Akuta; Miharu Hirakawa; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Tetsuya Hosaka; Masahiro Kobayashi; Fumitaka Suzuki; Yoshiyuki Suzuki; Mariko Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Virological and biochemical features in elderly HCV patients with hepatocellular carcinoma: amino acid substitutions in HCV core region as predictor of mortality after first treatment.
Intervirology 2009;52(4):179-88.
2009: Yasuji Arase; Fumitaka Suzuki; Kenji Ikeda; Hiromitsu Kumada; Hiroshi Tsuji; Tetsuro Kobayashi
Multivariate analysis of risk factors for the development of type 2 diabetes in nonalcoholic fatty liver disease.
Journal of gastroenterology 2009;44(10):1064-70.
2009: Mariko Kobayashi; Fumitaka Suzuki; Norio Akuta; Yoshiyuki Suzuki; Hitomi Sezaki; Hiromi Yatsuji; Yusuke Kawamura; Tetsuya Hosaka; Masahiro Kobayashi; Yasuji Arase; Kenji Ikeda; Rie Mineta; Satomi Iwasaki; Sachiyo Watahiki; Yuzo Miyakawa; Hiromitsu Kumada
Development of hepatocellular carcinoma in elderly patients with chronic hepatitis C with or without elevated aspartate and alanine aminotransferase levels.
Scandinavian journal of gastroenterology 2009;44(8):975-83.
2009: Hitomi Sezaki; Fumitaka Suzuki; Norio Akuta; Hiromi Yatsuji; Tetsuya Hosaka; Masahiro Kobayashi; Yoshiyuki Suzuki; Yasuji Arase; Kenji Ikeda; Yuzo Miyakawa; Hiromitsu Kumada
An open pilot study exploring the efficacy of fluvastatin, pegylated interferon and ribavirin in patients with hepatitis C virus genotype 1b in high viral loads.
Intervirology 2009;52(1):43-8.
2009: Yasuji Arase; Fumitaka Suzuki; Norio Akuta; Hitomi Sezaki; Yoshiyuki Suzuki; Yusuke Kawamura; Masahiro Kobayashi; Tetsuya Hosaka; Hiromi Yatsuji; Miharu Hirakawa; Satoshi Saito; Kenji Ikeda; Mariko Kobayashi; Hiromitsu Kumada
Combination therapy of peginterferon and ribavirin for chronic hepatitis C patients with genotype 1b and low-virus load.
Internal medicine (Tokyo, Japan) 2009;48(5):253-8.
2009: Fumitaka Suzuki; Hideo Miyakoshi; Mariko Kobayashi; Hiromitsu Kumada
Correlation between serum hepatitis B virus core-related antigen and intrahepatic covalently closed circular DNA in chronic hepatitis B patients.
Journal of medical virology 2009;81(1):27-33.
2008: Mariko Kobayashi; Kenji Ikeda; Yasuji Arase; Fumitaka Suzuki; Norio Akuta; Tetsuya Hosaka; Hitomi Sezaki; Hiromi Yatsuji; Masahiro Kobayashi; Yoshiyuki Suzuki; Sachiyo Watahiki; Rie Mineta; Satomi Iwasaki; Yuzo Miyakawa; Hiromitsu Kumada
Change of hepatitis B virus genotypes in acute and chronic infections in Japan.
Journal of medical virology 2008;80(11):1880-4.
2008: Yusuke Kawamura; Kenji Ikeda; Yasuji Arase; Hiromi Yatsuji; Hitomi Sezaki; Tetsuya Hosaka; Norio Akuta; Masahiro Kobayashi; Satoshi Saitoh; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Diabetes mellitus worsens the recurrence rate after potentially curative therapy in patients with hepatocellular carcinoma associated with nonviral hepatitis.
Journal of gastroenterology and hepatology 2008;23(11):1739-46.
2008: Yasuji Arase; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Masahiro Kobayashi; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Tetsuya Hosaka; Miharu Hirakawa; Satoshi Saito; Kenji Ikeda; Hiromitsu Kumada
Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis.
World journal of gastroenterology : WJG 2008;14(38):5880-6.
2008: Fumitaka Suzuki; Joji Toyoda; Yoshiaki Katano; Michio Sata; Mitsuhiko Moriyama; Fumio Imazeki; Masayoshi Kage; Taku Seriu; Masao Omata; Hiromitsu Kumada
Efficacy and safety of entecavir in lamivudine-refractory patients with chronic hepatitis B: randomized controlled trial in Japanese patients.
Journal of gastroenterology and hepatology 2008;23(9):1320-6.
2008: Yasuji Arase; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Hitomi Sezaki; Masahiro Kobayashi; Yusuke Kawamura; Hiromi Yatsuji; Tetsuya Hosaka; Satoshi Saito; Kenji Ikeda; Hiromitsu Kumada
Potential of laparoscopy in chronic liver disease with hepatitis B and C viruses.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(9):877-85.
2008: Norio Akuta; Fumitaka Suzuki; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Masahiro Kobayashi; Mariko Kobayashi; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Efficacy of low-dose intermittent interferon-alpha monotherapy in patients infected with hepatitis C virus genotype 1b who were predicted or failed to respond to pegylated interferon plus ribavirin combination therapy.
Journal of medical virology 2008;80(8):1363-9.
2008: Norio Akuta; Fumitaka Suzuki; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Masahiro Kobayashi; Mariko Kobayashi; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Substitution of amino acid 70 in the hepatitis C virus core region of genotype 1b is an important predictor of elevated alpha-fetoprotein in patients without hepatocellular carcinoma.
Journal of medical virology 2008;80(8):1354-62.
2008: Yasuji Arase; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Masahiro Kobayashi; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Tetsuya Hosaka; Kenji Ikeda; Hiromitsu Kumada
Prolonged-efficacy of bisphosphonate in postmenopausal women with osteoporosis and chronic liver disease.
Journal of medical virology 2008;80(7):1302-7.
2008: Hiromi Yatsuji; Fumitaka Suzuki; Hitomi Sezaki; Norio Akuta; Yoshiyuki Suzuki; Yusuke Kawamura; Tetsuya Hosaka; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Sachiyo Watahiki; Satomi Iwasaki; Mariko Kobayashi; Hiromitsu Kumada
Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up.
Journal of hepatology 2008;48(6):923-31.
2008: Hiromitsu Kumada
[Advance in technical method and treatment for viral hepatitis].
Rinsho byori. The Japanese journal of clinical pathology 2008;56(2):108-13.
2008: Miharu Hirakawa; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Tetsuya Hosaka; Hiromi Yatsuji; Hitomi Sezaki; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Hiromitsu Kumada
New ablation procedure for a radiofrequency liver tissue coagulation system using an expandable needle.
Liver international : official journal of the International Association for the Study of the Liver 2008;28(2):214-9.
2008: Norio Akuta; Fumitaka Suzuki; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Masahiro Kobayashi; Mariko Kobayashi; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Virological response and hepatocarcinogenesis in lamivudine-resistant hepatitis B virus genotype C patients treated with lamivudine plus adefovir dipivoxil.
Intervirology 2008;51(6):385-93.
2008: Miharu Hirakawa; Kenji Ikeda; Yusuke Kawamura; Masahiro Kobayashi; Tetsuya Hosaka; Hiromi Yatsuji; Hitomi Sezaki; Norio Akuta; Satoshi Saitoh; Fumitaka Suzuki; Yoshiyuki Suzuki; Yasuji Arase; Hiromitsu Kumada
Lipiodol and dye at the site of ablation decreases during RFA.
Intervirology 2008;51(5):362-8.
2008: Yoshio Katamura; Fumitaka Suzuki; Norio Akuta; Hitomi Sezaki; Hiromi Yatsuji; Norihiro Nomura; Yusuke Kawamura; Tetsuya Hosaka; Masahiro Kobayashi; Yoshiyuki Suzuki; Satoshi Saito; Yasuji Arase; Kenji Ikeda; Mariko Kobayashi; Hiromitsu Kumada
Natural human interferon beta plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus and a high viral load.
Internal medicine (Tokyo, Japan) 2008;47(21):1827-34.
2008: Yasuji Arase; Fumitaka Suzuki; Hitomi Sezaki; Yusuke Kawamura; Yoshiyuki Suzuki; Masahiro Kobayashi; Norio Akuta; Tetsuya Hosaka; Hiromi Yatsuji; Miharu Hirakawa; Mariko Kobayashi; Kenji Ikeda; Hiromitsu Kumada
The efficacy of 24-week interferon monotherapy for type C liver cirrhosis in Japanese patients with genotype 1b and low virus load.
Intervirology 2008;51(4):265-9.
2008: Miharu Hirakawa; Kenji Ikeda; Yasuji Arase; Yusuke Kawamura; Hiromi Yatsuji; Tetsuya Hosaka; Hitomi Sezaki; Norio Akuta; Masahiro Kobayashi; Satoshi Saitoh; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Hepatocarcinogenesis following HCV RNA eradication by interferon in chronic hepatitis patients.
Internal medicine (Tokyo, Japan) 2008;47(19):1637-43.
2008: Yasuji Arase; Fumitaka Suzuki; Hitomi Sezaki; Yoshiyuki Suzuki; Yusuke Kawamura; Masahiro Kobayashi; Norio Akuta; Tetsuya Hosaka; Hiromi Yatsuji; Kenji Ikeda; Mariko Kobayashi; Hiromitsu Kumada
Suitable treatment period in patients with virological response during combination therapy of peginterferon and ribavirin for chronic hepatitis C.
Internal medicine (Tokyo, Japan) 2008;47(14):1301-7.
2008: Yasuji Arase; Fumitaka Suzuki; Hitomi Sezaki; Yusuke Kawamura; Yoshiyuki Suzuki; Masahiro Kobayashi; Norio Akuta; Tetsuya Hosaka; Hiromi Yatsuji; Mariko Kobayashi; Satoshi Saitoh; Kenji Ikeda; Hiromitsu Kumada
The efficacy of short-term interferon-beta therapy for type C cirrhotic patients with genotype 2a and low virus load.
Internal medicine (Tokyo, Japan) 2008;47(12):1085-90.
2008: Yusuke Kawamura; Yasuji Arase; Kenji Ikeda; Fumitaka Suzuki; Yoshiyuki Suzuki; Masahiro Kobayashi; Norio Akuta; Tetsuya Hosaka; Hitomi Sezaki; Hiromi Yatsuji; Mariko Kobayashi; Hiromitsu Kumada
The efficacy of short-term interferon-beta therapy for chronic hepatitis C patients with low virus load.
Internal medicine (Tokyo, Japan) 2008;47(5):355-60.
2008: Yasuji Arase; Fumitaka Suzuki; Hitomi Sezaki; Yusuke Kawamura; Yoshiyuki Suzuki; Masahiro Kobayashi; Norio Akuta; Tetsuya Hosaka; Hiromi Yatsuji; Miharu Hirakawa; Mariko Kobayashi; Kenji Ikeda; Hiromitsu Kumada
Efficacy in patients with dose reduction in combination therapy of peginterferon and ribavirin for chronic hepatitis C.
Intervirology 2008;51(1):1-6.
2008: Masahiro Kobayashi; Kenji Ikeda; Yasuji Arase; Yoshiyuki Suzuki; Fumitaka Suzuki; Norio Akuta; Tetsuya Hosaka; N Murashima; Satoshi Saitoh; Takashi Someya; Akihito Tsubota; Hiromitsu Kumada
Inhibitory effect of branched-chain amino acid granules on progression of compensated liver cirrhosis due to hepatitis C virus.
Journal of gastroenterology 2008;43(1):63-70.
2008: Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Hiromi Yatsuji; Hitomi Sezaki; Yasuji Arase; Yusuke Kawamura; Tetsuya Hosaka; Masahiro Kobayashi; Kenji Ikeda; Mariko Kobayashi; Sachiyo Watahiki; Hiromitsu Kumada
Changes in viral loads of lamivudine-resistant mutants during entecavir therapy.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(2):132-40.
2007: Yusuke Kawamura; Kenji Ikeda; Yasuji Arase; Hiromi Yatsuji; Hitomi Sezaki; Tetsuya Hosaka; Norio Akuta; Masahiro Kobayashi; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Viral elimination reduces incidence of malignant lymphoma in patients with hepatitis C.
The American journal of medicine 2007;120(12):1034-41.
2007: Tomohiro Nishide; Kenji Ikeda; Yusuke Kawamura; Tetsuya Hosaka; Masahiro Kobayashi; Yoshiyuki Suzuki; Hiromitsu Kumada
Clinicopathological improvement of non-alcoholic steatohepatitis associated with weight loss during a 14-year follow-up period.
Liver international : official journal of the International Association for the Study of the Liver 2007;27(10):1422-7.
2007: Norio Akuta; Fumitaka Suzuki; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Masahiro Kobayashi; Mariko Kobayashi; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Predictors of viral kinetics to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b.
Journal of medical virology 2007;79(11):1686-95.
2007: Norio Akuta; Fumitaka Suzuki; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Mariko Kobayashi; Masahiro Kobayashi; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Amino acid substitutions in the hepatitis C virus core region are the important predictor of hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 2007;46(5):1357-64.
2007: Yasuji Arase; Kenji Ikeda; Fumitaka Suzuki; Yoshiyuki Suzuki; Masahiro Kobayashi; Norio Akuta; Tetsuya Hosaka; Hitomi Sezaki; Hiromi Yatsuji; Yusuke Kawamura; Mariko Kobayashi; Hiromitsu Kumada
Interferon-induced prolonged biochemical response reduces hepatocarcinogenesis in hepatitis C virus infection.
Journal of medical virology 2007;79(10):1485-90.
2007: Mariko Kobayashi; Fumitaka Suzuki; Norio Akuta; Tetsuya Hosaka; Hitomi Sezaki; Hiromi Yatsuji; Hiromi Yatsuji; Masahiro Kobayashi; Yoshiyuki Suzuki; Yasuji Arase; Kenji Ikeda; Sachiyo Watahiki; Satomi Iwasaki; Yuzo Miyakawa; Hiromitsu Kumada
Loss of hepatitis B surface antigen from the serum of patients with chronic hepatitis treated with lamivudine.
Journal of medical virology 2007;79(10):1472-7.
2007: Eiko Hasegawa; Masahiro Kobayashi; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Tetsuya Hosaka; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Efficacy and anticarcinogenic activity of interferon for hepatitis C virus-related compensated cirrhosis in patients with genotype 1b low viral load or genotype 2.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37(10):793-800.
2007: Hitomi Sezaki; Fumitaka Suzuki; Yusuke Kawamura; Hiromi Yatsuji; Tetsuya Hosaka; Norio Akuta; Masahiro Kobayashi; Yoshiyuki Suzuki; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Evaluation of long-term biochemical responses to combination therapy of interferon plus ribavirin in those infected with hepatitis C virus genotype 1b and high baseline viral load.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37(10):787-92.
2007: Yasuji Arase; Kenji Ikeda; Fumitaka Suzuki; Yoshiyuki Suzuki; Masahiro Kobayashi; Norio Akuta; Tetsuya Hosaka; Hitomi Sezaki; Hiromi Yatsuji; Yusuke Kawamura; Mariko Kobayashi; Hiromitsu Kumada
Comparison of interferon and lamivudine treatment in Japanese patients with HBeAg positive chronic hepatitis B.
Journal of medical virology 2007;79(9):1286-92.
2007: Yasuji Arase; Kenji Ikeda; Fumitaka Suzuki; Yoshiyuki Suzuki; Mariko Kobayashi; Norio Akuta; Tetsuya Hosaka; Hitomi Sezaki; Hiromi Yatsuji; Yusuke Kawamura; Masahiro Kobayashi; Hiromitsu Kumada
Prolonged-interferon therapy reduces hepatocarcinogenesis in aged-patients with chronic hepatitis C.
Journal of medical virology 2007;79(8):1095-102.
2007: Fumitaka Suzuki; Hiromitsu Kumada
Interferon and lamivudine monotherapy on chronic hepatitis B in Japan.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37(s1):S42-6.
2007: Fumitaka Suzuki; Norio Akuta; Yoshiyuki Suzuki; Hiromi Yatsuji; Hitomi Sezaki; Yasuji Arase; Yusuke Kawamura; Tetsuya Hosaka; Mariko Kobayashi; Kenji Ikeda; Masahiro Kobayashi; Sachiyo Watahiki; Hiromitsu Kumada
Selection of a virus strain resistant to entecavir in a nucleoside-naive patient with hepatitis B of genotype H.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2007;39(2):149-52.
2007: Tomokazu Kawaoka; Fumitaka Suzuki; Norio Akuta; Yoshiyuki Suzuki; Yasuji Arase; Hitomi Sezaki; Yusuke Kawamura; Tetsuya Hosaka; Masahiro Kobayashi; Kenji Ikeda; Hiromitsu Kumada
Efficacy of lamivudine therapy in elderly patients with chronic hepatitis B infection.
Journal of gastroenterology 2007;42(5):395-401.
2007: Tetsuya Hosaka; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; Takashi Someya; Hitomi Sezaki; Norio Akuta; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Factors associated with the virological response of lamivudine-resistant hepatitis B virus during combination therapy with adefovir dipivoxil plus lamivudine.
Journal of gastroenterology 2007;42(5):368-74.
2007: Masahiro Kobayashi; Kenji Ikeda; Yusuke Kawamura; Tetsuya Hosaka; Hitomi Sezaki; Hiromi Yatsuji; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Yasuji Arase; Hiromitsu Kumada
Randomized controlled trial for the efficacy of hepatic arterial occlusion during radiofrequency ablation for small hepatocellular carcinoma--direct ablative effects and a long-term outcome.
Liver international : official journal of the International Association for the Study of the Liver 2007;27(3):353-9.
2007: Norio Akuta; Fumitaka Suzuki; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Mariko Kobayashi; Masahiro Kobayashi; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Predictive factors of early and sustained responses to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b: amino acid substitutions in the core region and low-density lipoprotein cholesterol levels.
Journal of hepatology 2007;46(3):403-10.
2007: Norio Chihara; Yasuji Arase; Fumitaka Suzuki; Yoshiyuki Suzuki; Mariko Kobayashi; Norio Akuta; Tetsuya Hosaka; Hitomi Sezaki; Hiromi Yatsuji; Yusuke Kawamura; Masahiro Kobayashi; Sachiyo Watahiki; Kenji Ikeda; Hiromitsu Kumada
Prolonged hepatitis after acute infection with genotype H hepatitis B virus.
Internal medicine (Tokyo, Japan) 2007;46(22):1847-51.
2007: Yasuji Arase; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Yusuke Kawamura; Masahiro Kobayashi; Tetsuya Hosaka; Hitomi Sezaki; Hiromi Yatsuji; Mariko Kobayashi; Kenji Ikeda; Hiromitsu Kumada
Side effects of combination therapy of peginterferon and ribavirin for chronic hepatitis-C.
Internal medicine (Tokyo, Japan) 2007;46(22):1827-32.
2007: Norio Akuta; Fumitaka Suzuki; Yusuke Kawamura; Hiromi Yatsuji; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Mariko Kobayashi; Masahiro Kobayashi; Yasuji Arase; Kenji Ikeda; Yuzo Miyakawa; Hiromitsu Kumada
Prediction of response to pegylated interferon and ribavirin in hepatitis C by polymorphisms in the viral core protein and very early dynamics of viremia.
Intervirology 2007;50(5):361-8.
2007: Yasuji Arase; Kenji Ikeda; Yoshiyuki Suzuki; Masahiro Kobayashi; Fumitaka Suzuki; Norio Akuta; Hitomi Sezaki; Tetsuya Hosaka; Hiromi Yatsuji; Yusuke Kawamura; Mariko Kobayashi; Hiromitsu Kumada
Serum KL-6 level is elevated in chronic hepatitis C patients with combination therapy of pegylated interferon and ribavirin.
Internal medicine (Tokyo, Japan) 2007;46(15):1155-60.
2007: Yasuji Arase; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; Norio Akuta; Takashi Someya; Tetsuya Hosaka; Hitomi Sezaki; Junko Sato; Mariko Kobayashi; Kenji Ikeda; Hiromitsu Kumada
Long-term presence of HBV in the sera of chronic hepatitis B patients with HBsAg seroclearance.
Intervirology 2007;50(3):161-5.
2006: Takashi Someya; Kenji Ikeda; Satoshi Saitoh; Masahiro Kobayashi; Tetsuya Hosaka; Hitomi Sezaki; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Yasuji Arase; Hiromitsu Kumada
Interferon lowers tumor recurrence rate after surgical resection or ablation of hepatocellular carcinoma: a pilot study of patients with hepatitis B virus-related cirrhosis.
Journal of gastroenterology 2006;41(12):1206-13.
2006: Kenji Ikeda; Yasuji Arase; Satoshi Saitoh; Masahiro Kobayashi; Takashi Someya; Tetsuya Hosaka; Hitomi Sezaki; Norio Akuta; Yoshiyuki Suzuki; Fumitaka Suzuki; Hiromitsu Kumada
Long-term outcome of HBV carriers with negative HBe antigen and normal aminotransferase.
The American journal of medicine 2006;119(11):977-85.
2006: Mariko Kobayashi; Fumitaka Suzuki; Norio Akuta; Yoshiyuki Suzuki; Yasuji Arase; Kenji Ikeda; Tetsuya Hosaka; Hitomi Sezaki; Masahiro Kobayashi; Satomi Iwasaki; Junko Sato; Sachiyo Watahiki; Yuzo Miyakawa; Hiromitsu Kumada
Response to long-term lamivudine treatment in patients infected with hepatitis B virus genotypes A, B, and C.
Journal of medical virology 2006;78(10):1276-83.
2006: Fumitaka Suzuki; Hiromitsu Kumada; Hirotoshi Nakamura
Changes in viral loads of lamivudine-resistant mutants and evolution of HBV sequences during adefovir dipivoxil therapy.
Journal of medical virology 2006;78(8):1025-34.
2006: Kiminori Uka; Fumitaka Suzuki; Norio Akuta; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Efficacy of interferon monotherapy in young adult patients with chronic hepatitis C virus infection.
Journal of gastroenterology 2006;41(5):470-5.
2006: Masahiro Kobayashi; Kenji Ikeda; Tetsuya Hosaka; Hitomi Sezaki; Takashi Someya; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Yuzo Miyakawa; Hiromitsu Kumada
Natural history of compensated cirrhosis in the Child-Pugh class A compared between 490 patients with hepatitis C and 167 with B virus infections.
Journal of medical virology 2006;78(4):459-65.
2006: Kenji Ikeda; Yasuji Arase; Masahiro Kobayashi; Satoshi Saitoh; Takashi Someya; Tetsuya Hosaka; Hitomi Sezaki; Norio Akuta; Yoshiyuki Suzuki; Fumitaka Suzuki; Hiromitsu Kumada
A long-term glycyrrhizin injection therapy reduces hepatocellular carcinogenesis rate in patients with interferon-resistant active chronic hepatitis C: a cohort study of 1249 patients.
Digestive diseases and sciences 2006;51(3):603-9.
2006: Fumitaka Suzuki; Norio Akuta; Yoshiyuki Suzuki; Hitomi Sezaki; Yasuji Arase; Tetsuya Hosaka; Takashi Someya; Mariko Kobayashi; Satoshi Saitoh; Kenji Ikeda; Masahiro Kobayashi; Marie Matsuda; Junko Satoh; Sachiyo Watahiki; Hiromitsu Kumada
Clinical and virological features of non-breakthrough and severe exacerbation due to lamivudine-resistant hepatitis B virus mutants.
Journal of medical virology 2006;78(3):341-52.
2006: Masahiro Kobayashi; Kenji Ikeda; Tetsuya Hosaka; Hitomi Sezaki; Takashi Someya; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Hiromitsu Kumada
Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis.
Cancer 2006;106(3):636-47.
2006: Hitomi Sezaki; Fumitaka Suzuki; Tetsuya Hosaka; Norio Akuta; Takashi Someya; Masahiro Kobayashi; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Long-term follow-up of HBeAg-positive young adult Japanese patients treated with corticosteroid withdrawal therapy for chronic hepatitis B.
Intervirology 2006;49(6):339-45.
2006: Kenji Ikeda; Masahiro Kobayashi; Satoshi Saitoh; Takashi Someya; Tetsuya Hosaka; Hitomi Sezaki; Yoshiyuki Suzuki; Fumitaka Suzuki; Norio Akuta; Yasuji Arase; Hiromitsu Kumada
Origin of neovascular structure in an early stage of hepatocellular carcinoma: study of alpha-smooth muscle actin immunohistochemistry in serial thin sections of surgically resected cancer.
Journal of gastroenterology and hepatology 2006;21(1 Pt 1):183-90.
2006: Yasuji Arase; Kenji Ikeda; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; Norio Akuta; Takashi Someya; Tetsuya Hosaka; Hitomi Sezaki; Mariko Kobayashi; Hiromitsu Kumada
Long-term outcome after hepatitis B surface antigen seroclearance in patients with chronic hepatitis B.
The American journal of medicine 2006;119(1):71.e9-16.
2006: Mariko Kobayashi; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Yasuji Arase; Kenji Ikeda; Tetsuya Hosaka; Satoshi Saitoh; Masahiro Kobayashi; Takashi Someya; Junko Sato; Sachiyo Watabiki; Yuzo Miyakawa; Hiromitsu Kumada
Virological outcomes in patients infected chronically with hepatitis B virus genotype A in comparison with genotypes B and C.
Journal of medical virology 2006;78(1):60-7.
2006: Norio Akuta; Fumitaka Suzuki; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Takashi Someya; Mariko Kobayashi; Satoshi Saitoh; Sachiyo Watahiki; Junko Sato; Masahiro Kobayashi; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Predictive factors of virological non-response to interferon-ribavirin combination therapy for patients infected with hepatitis C virus of genotype 1b and high viral load.
Journal of medical virology 2006;78(1):83-90.
2006: Kenji Ikeda; Yasuji Arase; Satoshi Saitoh; Masahiro Kobayashi; Takashi Someya; Tetsuya Hosaka; Hitomi Sezaki; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Anticarcinogenic impact of interferon on patients with chronic hepatitis C: a large-scale long-term study in a single center.
Intervirology 2006;49(1-2):82-90.
2005: Kenji Ikeda; Masahiro Kobayashi; Satoshi Saitoh; Takashi Someya; Tetsuya Hosaka; Hitomi Sezaki; Yoshiyuki Suzuki; Fumitaka Suzuki; Norio Akuta; Yasuji Arase; Hiromitsu Kumada; Masamichi Matsuda; Masaji Hashimoto; Goro Watanabe
Cost-effectiveness of radiofrequency ablation and surgical therapy for small hepatocellular carcinoma of 3cm or less in diameter.
Hepatology research : the official journal of the Japan Society of Hepatology 2005;33(3):241-9.
2005: Yusuke Kawamura; Norio Akuta; Hitomi Sezaki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Determinants of serum ALT normalization after phlebotomy in patients with chronic hepatitis C infection.
Journal of gastroenterology 2005;40(9):901-6.
2005: Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Hitomi Sezaki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Mariko Kobayashi; Hiromitsu Kumada
Long-term follow-up of interferon monotherapy in 454 consecutive naive patients infected with hepatitis C virus: multi-course interferon therapy may reduce the risk of hepatocellular carcinoma and increase survival.
Scandinavian journal of gastroenterology 2005;40(6):688-96.
2005: Yoshiyuki Suzuki; Masahiro Kobayashi; Kenji Ikeda; Fumitaka Suzuki; Yasuji Arfase; Norio Akuta; Tetsuya Hosaka; Satoshi Saitoh; Mariko Kobayashi; Takashi Someya; Marie Matsuda; Junko Sato; Sachiyo Watabiki; Yuzo Miyakawa; Hiromitsu Kumada
Persistence of acute infection with hepatitis B virus genotype A and treatment in Japan.
Journal of medical virology 2005;76(1):33-9.
2005: Mariko Kobayashi; Fumitaka Suzuki; Norio Akuta; Akihito Tsubota; Kenji Ikeda; Yasuji Arase; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; Tetsuya Hosaka; Takashi Someya; Marie Matsuda; Junko Sato; Yuzo Miyakawa; Hiromitsu Kumada
Virological differences between patients infected with subtypes Ba and Bj of hepatitis B virus genotype B.
Journal of gastroenterology and hepatology 2005;20(4):570-6.
2005: Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Hitomi Sezaki; Tetsuya Hosaka; Takashi Someya; Mariko Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Masahiro Kobayashi; Hiromitsu Kumada
Hepatocyte steatosis is an important predictor of response to interferon (IFN) monotherapy in Japanese patients infected with HCV genotype 2a: Virological features of IFN-resistant cases with hepatocyte steatosis.
Journal of medical virology 2005;75(4):550-8.
2005: Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Hitomi Sezaki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Mariko Kobayashi; Hiromitsu Kumada
Favorable efficacy of long-term lamivudine therapy in patients with chronic hepatitis B: an 8-year follow-up study.
Journal of medical virology 2005;75(4):491-8.
2005: Akihito Tsubota; Yasuji Arase; Yoshiyuki Suzuki; Fumitaka Suzuki; Hitomi Sezaki; Tetsuya Hosaka; Norio Akuta; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Kenji Ikeda; Hiromitsu Kumada
Lamivudine monotherapy for spontaneous severe acute exacerbation of chronic hepatitis B.
Journal of gastroenterology and hepatology 2005;20(3):426-32.
2005: Norio Akuta; Hiromitsu Kumada
Influence of hepatitis B virus genotypes on the response to antiviral therapies.
The Journal of antimicrobial chemotherapy 2005;55(2):139-42.
2005: Nobuhiko Hiraga; Fumitaka Suzuki; Norio Akuta; Yoshiyuki Suzuki; Hitomi Sezaki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Mariko Kobayashi; Marie Matsuda; Sachiyo Watabiki; Junko Satoh; Hiromitsu Kumada
Clinical and virological characteristics of untreated patients with chronic hepatitis C who develop serum alanine aminotransferase flare-up.
Journal of medical virology 2005;75(2):240-8.
2005: Norio Akuta; Fumitaka Suzuki; Hitomi Sezaki; Yoshiyuki Suzuki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Sachiyo Watahiki; Junko Sato; Marie Matsuda; Mariko Kobayashi; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy.
Intervirology 2005;48(6):372-80.
2005: Kenji Ikeda; Hiromitsu Kumada
Locoregional therapy for hepatocellular carcinoma.
Tropical gastroenterology : official journal of the Digestive Diseases Foundation 2005;26(1):4-12.
2005: Norio Akuta; Fumitaka Suzuki; Mariko Kobayashi; Marie Matsuda; Junko Sato; Yoshiyuki Suzuki; Hitomi Sezaki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Virological and biochemical relapse after discontinuation of lamivudine monotherapy for chronic hepatitis B in Japan: comparison with breakthrough hepatitis during long-term treatment.
Intervirology 2005;48(2-3):174-82.
2005: Yasuji Arase; Kenji Ikeda; Akihito Tsubota; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Mariko Kobayashi; Norio Akuta; Takashi Someya; Tetsuya Hosaka; Hitomi Sezaki; Masahiro Kobayashi; Hiromitsu Kumada
Significance of serum ribavirin concentration in combination therapy of interferon and ribavirin for chronic hepatitis C.
Intervirology 2005;48(2-3):138-44.
2005: Kenji Ikeda; Yasuji Arase; Masahiro Kobayashi; Takashi Someya; Tetsuya Hosaka; Satoshi Saitoh; Hitomi Sezaki; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Hiromitsu Kumada
Hepatitis B virus-related hepatocellular carcinogenesis and its prevention.
Intervirology 2005;48(1):29-38.
2005: Kenji Ikeda; Masahiro Kobayashi; Satoshi Saitoh; Takashi Someya; Tetsuya Hosaka; Norio Akuta; Yoshiyuki Suzuki; Fumitaka Suzuki; Akihito Tsubota; Yasuji Arase; Hiromitsu Kumada
Significance of hepatitis B virus DNA clearance and early prediction of hepatocellular carcinogenesis in patients with cirrhosis undergoing interferon therapy: long-term follow up of a pilot study.
Journal of gastroenterology and hepatology 2005;20(1):95-102.
2005: Akihito Tsubota; Yasuji Arase; Takashi Someya; Yoshiyuki Suzuki; Fumitaka Suzuki; Satoshi Saitoh; Kenji Ikeda; Norio Akuta; Tetsuya Hosaka; Masahiro Kobayashi; Hiromitsu Kumada
Early viral kinetics and treatment outcome in combination of high-dose interferon induction vs. pegylated interferon plus ribavirin for naive patients infected with hepatitis C virus of genotype 1b and high viral load.
Journal of medical virology 2005;75(1):27-34.
2004: Hiromi Ooga; Fumitaka Suzuki; Akihito Tsubota; Yasuji Arase; Yoshiyuki Suzuki; Norio Akuta; Hitomi Sezaki; Tetsuya Hosaka; Takashi Someya; Mariko Kobayashi; Satoshi Saitoh; Kenji Ikeda; Masahiro Kobayashi; Marie Matsuda; Junko Satoh; Hiromitsu Kumada
Efficacy of lamivudine treatment in Japanese patients with hepatitis B virus-related cirrhosis.
Journal of gastroenterology 2004;39(11):1078-84.
2004: Fumitaka Suzuki; Yasuji Arase; Norio Akuta; Akihito Tsubota; Yoshiyuki Suzuki; Hitomi Sezaki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Kenji Ikeda; Mariko Kobayashi; Marie Matsuda; Junko Satoh; Hiromitsu Kumada
Efficacy of 6-month interferon therapy in chronic hepatitis B virus infection in Japan.
Journal of gastroenterology 2004;39(10):969-74.
2004: Marie Matsuda; Fumitaka Suzuki; Yoshiyuki Suzuki; Akihito Tsubota; Norio Akuta; Tetsuya Hosaka; Takashi Someya; Mariko Kobayashi; Satoshi Saitoh; Yasuji Arase; Junko Satoh; Masahiro Kobayashi; Kenji Ikeda; Yuzo Miyakawa; Hiromitsu Kumada
YMDD mutants in patients with chronic hepatitis B before treatment are not selected by lamivudine.
Journal of medical virology 2004;74(2):361-6.
2004: Mariko Kobayashi; Fumitaka Suzuki; Yasuji Arase; Norio Akuta; Yoshiyuki Suzuki; Tetsuya Hosaka; Satoshi Saitoh; Masahiro Kobayashi; Akihito Tsubota; Takashi Someya; Kenji Ikeda; Marie Matsuda; Junko Sato; Hiromitsu Kumada
Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001.
Journal of gastroenterology 2004;39(9):844-50.
2004: Norio Akuta; Hiromitsu Kumada
[Corticosteroid withdrawal therapy in patients with chronic hepatitis B virus infection].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 8():345-8.
2004: Fumitaka Suzuki; Hiromitsu Kumada
[HBs antigen, HBs antibody (anti-HBs)].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 8():121-3.
2004: Satoshi Mamori; Fumitaka Suzuki; Tetsuya Hosaka; Norio Akuta; Takashi Someya; Masahiro Kobayashi; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Interferon monotherapy for patients with chronic hepatitis C and normal serum aminotransferase levels at commencement of treatment.
Journal of gastroenterology 2004;39(8):776-82.
2004: Yoshiyuki Suzuki; Masahiro Kobayashi; Tetsuya Hosaka; Takashi Someya; Norio Akuta; Mariko Kobayashi; Fumitaka Suzuki; Akihito Tsubota; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Marie Matsuda; Junko Sato; Yuzo Miyakawa; Hiromitsu Kumada
Peripheral CD8+/CD25+ lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune hepatitis.
Journal of gastroenterology 2004;39(7):649-53.
2004: Hitomi Sezaki; Mariko Kobayashi; Tetsuya Hosaka; Takashi Someya; Norio Akuta; Fumitaka Suzuki; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Masahiro Kobayashi; Marie Matsuda; Kimiko Takagi; Junko Sato; Hiromitsu Kumada
Hepatocellular carcinoma in noncirrhotic young adult patients with chronic hepatitis B viral infection.
Journal of gastroenterology 2004;39(6):550-6.
2004: Yoshiyuki Suzuki; Yasuji Arase; Kenji Ikeda; Satoshi Saitoh; Akihito Tsubota; Fumitaka Suzuki; Masahiro Kobayashi; Norio Akuta; Takashi Someya; Yuzo Miyakawa; Hiromitsu Kumada
Clinical and pathological characteristics of the autoimmune hepatitis and primary biliary cirrhosis overlap syndrome.
Journal of gastroenterology and hepatology 2004;19(6):699-706.
2004: Fumitaka Suzuki; Yasuji Arase; Yoshiyuki Suzuki; Akihito Tsubota; Norio Akuta; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Kenji Ikeda; M Kobayashi; M Matsuda; K Takagi; J Satoh; Hiromitsu Kumada
Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection.
Journal of viral hepatitis 2004;11(3):271-6.
2004: Akihito Tsubota; Yasuji Arase; Fumitaka Suzuki; Mariko Kobayashi; Marie Matsuda; Junko Sato; Yoshiyuki Suzuki; Norio Akuta; Hitomi Sezaki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Kenji Ikeda; Hiromitsu Kumada
Severe acute exacerbation of liver disease may reduce or delay emergence of YMDD motif mutants in long-term lamivudine therapy for hepatitis B e antigen-positive chronic hepatitis B.
Journal of medical virology 2004;73(1):7-12.
2004: Norio Akuta; Fumitaka Suzuki; Mariko Kobayashi; Akihito Tsubota; Yoshiyuki Suzuki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Effect of acute self-limited hepatitis C virus (HCV) superinfection on hepatitis B virus (HBV)-related cirrhosis. Virological features of HBV-HCV dual infection.
Digestive diseases and sciences 2004;49(2):281-8.
2004: Tetsuya Hosaka; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; Takashi Someya; Hitomi Sezaki; Norio Akuta; Akihito Tsubota; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Adefovir dipivoxil for treatment of breakthrough hepatitis caused by lamivudine-resistant mutants of hepatitis B virus.
Intervirology 2004;47(6):362-9.
2004: Yasuji Arase; Kenji Ikeda; Akihito Tsubota; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; Norio Akuta; Takashi Someya; Tetsuya Hosaka; Hitomi Sezaki; Mariko Kobayashi; Hiromitsu Kumada
Interferon therapy for 2 years or longer reduces the incidence of hepatocarcinogenesis in patients with chronic hepatitis C viral infection.
Intervirology 2004;47(6):355-61.
2004: Yasuji Arase; Kenji Ikeda; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Mariko Kobayashi; Fumitaka Suzuki; Norio Akuta; Takashi Someya; Tetsuya Hosaka; Masahiro Kobayashi; Hiromitsu Kumada
Efficacy of interferon retreatment after relapse for chronic hepatitis C patients with biochemical response after first interferon therapy.
Journal of gastroenterology 2004;39(5):455-60.
2004: Akihito Tsubota; Yasuji Arase; Fumitaka Suzuki; Yoshiyuki Suzuki; Norio Akuta; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Kenji Ikeda; Hiromitsu Kumada
High-dose interferon alpha-2b induction therapy in combination with ribavirin for Japanese patients infected with hepatitis C virus genotype 1b with a high baseline viral load.
Journal of gastroenterology 2004;39(2):155-61.
2004: Yasuji Arase; Fumitaka Suzuki; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Mariko Kobayashi; Norio Akuta; Takashi Someya; Tetsuya Hosaka; Masahiro Kobayashi; Hitomi Sezaki; Kenji Ikeda; Hiromitsu Kumada
Sustained negativity for HCV-RNA over 24 or more months by long-term interferon therapy correlates with eradication of HCV in patients with hepatitis C virus genotype 1b and high viral load.
Intervirology 2004;47(1):19-25.
2004: Marie Matsuda; Fumitaka Suzuki; Yoshiyuki Suzuki; Akihito Tsubota; Norio Akuta; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Junko Satoh; Kimiko Takagi; Mariko Kobayashi; Kenji Ikeda; Hiromitsu Kumada
Low rate of YMDD motif mutations in polymerase gene of hepatitis B virus in chronically infected patients not treated with lamivudine.
Journal of gastroenterology 2004;39(1):34-40.
2003: Yasuji Arase; Akihito Tsubota; Yoshiyuki Suzuki; Fumitaka Suzuki; Masahiro Kobayashi; Takashi Someya; Norio Akuta; Tetsuya Hosaka; Satoshi Saitoh; Kenji Ikeda; Mariko Kobayashi; Hiromitsu Kumada
A pilot study of thymosin alpha1 therapy for chronic hepatitis B patients.
Internal medicine (Tokyo, Japan) 2003;42(10):941-6.
2003: Fumitaka Suzuki; Akihito Tsubota; Yasuji Arase; Yoshiyuki Suzuki; Norio Akuta; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Kenji Ikeda; Mariko Kobayashi; Marie Matsuda; Junko Satoh; Kimiko Takagi; Hiromitsu Kumada
HBe antigen loss during lamivudine therapy is not caused by mutations in precore and core promoter genes in patients with chronic hepatitis B.
Journal of medical virology 2003;70(3):355-60.
2003: Akihito Tsubota; Yuichi Hirose; Namiki Izumi; Hiromitsu Kumada
Pharmacokinetics of ribavirin in combined interferon-alpha 2b and ribavirin therapy for chronic hepatitis C virus infection.
British journal of clinical pharmacology 2003;55(4):360-7.
2003: Norio Akuta; Fumitaka Suzuki; Mariko Kobayashi; Akihito Tsubota; Yoshiyuki Suzuki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
The influence of hepatitis B virus genotype on the development of lamivudine resistance during long-term treatment.
Journal of hepatology 2003;38(3):315-21.
2003: Norio Akuta; Fumitaka Suzuki; Akihito Tsubota; Yoshiyuki Suzuki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Association of amino acid substitution pattern in nonstructural protein 5A of hepatitis C virus genotype2a low viral load and response to interferon monotherapy.
Journal of medical virology 2003;69(3):376-83.
2003: Hiromitsu Kumada
Continued lamivudine therapy in patients with chronic hepatitis B.
Intervirology 2003;46(6):377-87.
2003: Kenji Ikeda; Masahiro Kobayashi; Satoshi Saitoh; Takashi Someya; Tetsuya Hosaka; Norio Akuta; Fumitaka Suzuki; Akihito Tsubota; Yoshiyuki Suzuki; Yasuji Arase; Hiromitsu Kumada
Recurrence rate and prognosis of patients with hepatocellular carcinoma that developed after elimination of hepatitis C virus RNA by interferon therapy. A closed cohort study including matched control patients.
Oncology 2003;65(3):204-10.
2003: Kenji Ikeda; Yasuji Arase; Masahiro Kobayashi; Satoshi Saitoh; Takashi Someya; Tetsuya Hosaka; Yoshiyuki Suzuki; Fumitaka Suzuki; Akihito Tsubota; Norio Akuta; Hiromitsu Kumada
Significance of multicentric cancer recurrence after potentially curative ablation of hepatocellular carcinoma: a longterm cohort study of 892 patients with viral cirrhosis.
Journal of gastroenterology 2003;38(9):865-76.
2003: Mariko Kobayashi; Yasuji Arase; Kenji Ikeda; Akihito Tsubota; Yoshiyuki Suzuki; Tetsuya Hosaka; Satoshi Saitoh; Masahiro Kobayashi; Fumitaka Suzuki; Norio Akuta; Takashi Someya; Marie Matsuda; Junko Sato; Hiromitsu Kumada
Clinical features of hepatitis B virus genotype A in Japanese patients.
Journal of gastroenterology 2003;38(7):656-62.
2003: Fumitaka Suzuki; Akihito Tsubota; Yasuji Arase; Yoshiyuki Suzuki; Norio Akuta; Tetsuya Hosaka; Takashi Someya; Mariko Kobayashi; Satoshi Saitoh; Kenji Ikeda; Masahiro Kobayashi; Marie Matsuda; Junko Satoh; Kimiko Takagi; Hiromitsu Kumada
Efficacy of lamivudine therapy and factors associated with emergence of resistance in chronic hepatitis B virus infection in Japan.
Intervirology 2003;46(3):182-9.
2003: Yoshiyuki Suzuki; Yasuji Arase; Kenji Ikeda; Satoshi Saitoh; Akihito Tsubota; Fumitaka Suzuki; Masahiro Kobayashi; Norio Akuta; Takashi Someya; Yuzo Miyakawa; Hiromitsu Kumada
Histological improvements after a three-year lamivudine therapy in patients with chronic hepatitis B in whom YMDD mutants did not or did develop.
Intervirology 2003;46(3):164-70.
2003: Mariko Kobayashi; Yasuji Arase; Kenji Ikeda; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; Fumitaka Suzuki; Norio Akuta; Tetsuya Hosaka; Takashi Someya; Marie Matsuda; Junko Sato; Kimiko Takagi; Yuzo Miyakawa; Hiromitsu Kumada
Precore wild-type hepatitis B virus with G1896 in the resolution of persistent hepatitis B virus infection.
Intervirology 2003;46(3):157-63.
2003: Hitomi Sezaki; Yasuji Arase; Akihito Tsubota; Yoshiyuki Suzuki; Masahiro Kobayashi; Satoshi Saitoh; Fumitaka Suzuki; Norio Akuta; Takashi Someya; Kenji Ikeda; Hiromitsu Kumada
Type C-chronic hepatitis patients who had autoimmune phenomenon and developed jaundice during interferon therapy.
Journal of gastroenterology 2003;38(5):493-500.
2003: Kenji Ikeda; Yasuji Arase; Masahiro Kobayashi; Takashi Someya; Satoshi Saitoh; Yoshiyuki Suzuki; Fumitaka Suzuki; Akihito Tsubota; Norio Akuta; Hiromitsu Kumada
Consistently low hepatitis B virus DNA saves patients from hepatocellular carcinogenesis in HBV-related cirrhosis. A nested case-control study using 96 untreated patients.
Intervirology 2003;46(2):96-104.
2003: Yasuji Arase; Kenji Ikeda; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; Mariko Kobayashi; Fumitaka Suzuki; Norio Akuta; Takashi Someya; Hiromitsu Kumada
Efficacy of prolonged interferon therapy for patients with chronic hepatitis C with HCV-genotype 1b and high virus load.
Journal of gastroenterology 2003;38(2):158-63.
2003: Norio Akuta; Akihito Tsubota; Fumitaka Suzuki; Yoshiyuki Suzuki; Tetsuya Hosaka; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Long-term prognosis by lamivudine monotherapy for severe acute exacerbation in chronic hepatitis B infection: emergence of YMDD motif mutant and risk of breakthrough hepatitis -- an open-cohort study.
Journal of hepatology 2003;38(1):91-7.
2002: Fumitaka Suzuki; Yoshiyuki Suzuki; Akihito Tsubota; Norio Akuta; Takashi Someya; Masahiro Kobayashi; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy.
Journal of hepatology 2002;37(6):824-30.
2002: Mariko Kobayashi; Yasuji Arase; Kenji Ikeda; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; Fumitaka Suzuki; Norio Akuta; Takashi Someya; Marie Matsuda; Junko Sato; Kimiko Takagi; Yuzo Miyakawa; Hiromitsu Kumada
Viral genotypes and response to interferon in patients with acute prolonged hepatitis B virus infection of adulthood in Japan.
Journal of medical virology 2002;68(4):522-8.
2002: Hiromitsu Kumada
[Treatment of chronic hepatitis B].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2002;99(2):131-8.
2002: Masahiro Kobayashi; Kenji Ikeda; Takashi Someya; Norio Akuta; Fumitaka Suzuki; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Hiromitsu Kumada
Stepwise hook extension technique for radiofrequency ablation therapy of hepatocellular carcinoma.
Oncology 2002;63(2):139-44.
2002: Kenji Ikeda; Masahiro Kobayashi; Takashi Someya; Satoshi Saitoh; Akihito Tsubota; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Yasuji Arase; Hiromitsu Kumada
Influence of hepatitis C virus subtype on hepatocellular carcinogenesis: a multivariate analysis of a retrospective cohort of 593 patients with cirrhosis.
Intervirology 2002;45(2):71-8.
2002: Akihito Tsubota; Norio Akuta; Fumitaka Suzuki; Yoshiyuki Suzuki; Takahi Someya; Masahiro Kobayashi; Yasuji Arase; Satoshi Saitoh; Kenji Ikeda; Hiromitsu Kumada
Viral dynamics and pharmacokinetics in combined interferon alfa-2b and ribavirin therapy for patients infected with hepatitis C virus of genotype 1b and high pretreatment viral load.
Intervirology 2002;45(1):33-42.
2002: Hiromitsu Kumada
Long-term treatment of chronic hepatitis C with glycyrrhizin [stronger neo-minophagen C (SNMC)] for preventing liver cirrhosis and hepatocellular carcinoma.
Oncology 2002;62 Suppl 1():94-100.
2002: Mariko Kobayashi; Yasuji Arase; Kenji Ikeda; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; Fumitaka Suzuki; Norio Akuta; Takashi Someya; Marie Matsuda; Junko Sato; Hiromitsu Kumada
Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C.
Journal of gastroenterology 2002;37(1):35-9.
2001: Akihito Tsubota; Yasuji Arase; F Ren; H Tanaka; Kenji Ikeda; Hiromitsu Kumada
Genotype may correlate with liver carcinogenesis and tumor characteristics in cirrhotic patients infected with hepatitis B virus subtype adw.
Journal of medical virology 2001;65(2):257-65.
2001: Kenji Ikeda; Yasuji Arase; Hiromitsu Kumada
[Hepatocellular carcinogenesis and prognosis of elderly patients with chronic hepatitis type C].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(7):1338-44.
2001: Yasuji Arase; Hiromitsu Kumada
[A trial of new interferon therapy for the patients with chronic hepatitis C resistant to interferon therapy].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(7):1309-14.
2001: N Murachima; Kenji Ikeda; Masahiro Kobayashi; Satoshi Saitoh; Kazuaki Chayama; Akihito Tsubota; Yoshiyuki Suzuki; Fumitaka Suzuki; Yasuji Arase; Hiromitsu Kumada
Incidence of the appearance of the red color sign on esophageal varices and its predictive factors: long-term observations of 359 patients with cirrhosis.
Journal of gastroenterology 2001;36(6):368-74.
2001: Hiromitsu Kumada
[Chronic hepatitis B].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2001;98(5):503-11.
2001: Kenji Ikeda; Satoshi Saitoh; Masahiro Kobayashi; Yoshiyuki Suzuki; Fumitaka Suzuki; Akihito Tsubota; Yasuji Arase; N Murashima; Kazuaki Chayama; Hiromitsu Kumada
Long-term interferon therapy for 1 year or longer reduces the hepatocellular carcinogenesis rate in patients with liver cirrhosis caused by hepatitis C virus: a pilot study.
Journal of gastroenterology and hepatology 2001;16(4):406-15.
2001: Fumitaka Suzuki; Kazuaki Chayama; Akihito Tsubota; Norio Akuta; Takashi Someya; Masahiro Kobayashi; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Twice-daily administration of interferon-beta for chronic hepatitis C is not superior to a once-daily regimen.
Journal of gastroenterology 2001;36(4):242-7.
2001: Akihito Tsubota; Yasuji Arase; Satoshi Saitoh; Masahiro Kobayashi; Yoshiyuki Suzuki; Fumitaka Suzuki; Kazuaki Chayama; N Murashima; Kenji Ikeda; M Kobayashi; Hiromitsu Kumada
Lamivudine therapy for spontaneously occurring severe acute exacerbation in chronic hepatitis B virus infection: a preliminary study.
The American journal of gastroenterology 2001;96(2):557-62.
2001: Takashi Someya; Yoshiyuki Suzuki; Yasuji Arase; Masahiro Kobayashi; Fumitaka Suzuki; Akihito Tsubota; Satoshi Saitoh; Kazuaki Chayama; N Murashima; Kenji Ikeda; Hiromitsu Kumada
Interferon therapy for flare-up of hepatitis B virus infection after emergence of lamivudine-induced YMDD motif mutant.
Journal of gastroenterology 2001;36(2):133-6.
2001: Fumitaka Suzuki; Kazuaki Chayama; Akihito Tsubota; Norio Akuta; Takashi Someya; Masahiro Kobayashi; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
Pathogenic significance and organic virus levels in patients infected with TT virus.
Intervirology 2001;44(5):291-7.
2000: Kazuaki Chayama; Fumitaka Suzuki; Akihito Tsubota; Masahiro Kobayashi; Yasuji Arase; Satoshi Saitoh; Yoshiyuki Suzuki; N Murashima; Kenji Ikeda; N Takahashi; M Kinoshita; Hiromitsu Kumada
Association of amino acid sequence in the PKR-eIF2 phosphorylation homology domain and response to interferon therapy.
Hepatology (Baltimore, Md.) 2000;32(5):1138-44.
2000: Kenji Ikeda; Yasuji Arase; Satoshi Saitoh; Masahiro Kobayashi; Yoshiyuki Suzuki; Fumitaka Suzuki; Akihito Tsubota; Kazuaki Chayama; N Murashima; Hiromitsu Kumada
Interferon beta prevents recurrence of hepatocellular carcinoma after complete resection or ablation of the primary tumor-A prospective randomized study of hepatitis C virus-related liver cancer.
Hepatology (Baltimore, Md.) 2000;32(2):228-32.
2000: Masahiro Kobayashi; Kenji Ikeda; Satoshi Saitoh; Fumitaka Suzuki; Akihito Tsubota; Yoshiyuki Suzuki; Yasuji Arase; N Murashima; Kazuaki Chayama; Hiromitsu Kumada
Incidence of primary cholangiocellular carcinoma of the liver in japanese patients with hepatitis C virus-related cirrhosis.
Cancer 2000;88(11):2471-7.
2000: M Kobyashi; Kazuaki Chayama; Yasuji Arase; Akihito Tsubota; Satoshi Saitoh; Yoshiyuki Suzuki; Masahiro Kobayashi; N Murashima; Kenji Ikeda; M Hagiwara; R Hashimoto; M Nakagawa; M Matsuda; Hiromitsu Kumada
Progressive and sufficient decrease of hepatitis B core antibody can predict the disappearance of hepatitis B virus DNA in Japanese patients with hepatitis B surface antigen clearance.
Journal of gastroenterology 2000;35(10):753-7.
2000: Masahiro Kobayashi; Kenji Ikeda; Norio Akuta; Takashi Someya; Fumitaka Suzuki; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Kazuaki Chayama; Hiromitsu Kumada
Relationship between five-year histological outcome and serial changes in serum alanine aminotransferase in patients with biochemical and virological relapse after interferon treatment for chronic hepatitis C.
Intervirology 2000;43(3):174-9.
2000: Yasuji Arase; Kenji Ikeda; Kazuaki Chayama; N Murashima; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; M Kobayashi; Fumitaka Suzuki; Hiromitsu Kumada
Increased response rate to interferon therapy after a second course in hepatitis C patients who show relapse after the initial course.
Journal of gastroenterology 2000;35(8):607-12.
2000: Kenji Ikeda; Satoshi Saitoh; Masahiro Kobayashi; Yoshiyuki Suzuki; Fumitaka Suzuki; Akihito Tsubota; Yasuji Arase; Kazuaki Chayama; N Murashima; Hiromitsu Kumada
Hepatic vascular side effects of styrene maleic acid neocarzinostatin in the treatment of hepatocellular carcinoma.
Journal of gastroenterology 2000;35(5):353-60.
2000: Yasuji Arase; Kenji Ikeda; Kazuaki Chayama; N Murashima; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; M Kobayashi; Fumitaka Suzuki; Hiromitsu Kumada
Fluctuation patterns of HCV-RNA serum level in patients with chronic hepatitis C.
Journal of gastroenterology 2000;35(3):221-5.
1999: Yasuji Arase; Kenji Ikeda; N Murashima; Kazuaki Chayama; Akihito Tsubota; I Koida; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; M Kobayashi; Hiromitsu Kumada
Time course of histological changes in patients with a sustained biochemical and virological response to corticosteroid withdrawal therapy for chronic hepatitis B.
The American journal of gastroenterology 1999;94(11):3304-9.
1999: Yasuji Arase; Kenji Ikeda; Kazuaki Chayama; N Murashima; Akihito Tsubota; I Nakamura; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; M Kobayashi; M Kobayashi; Hiromitsu Kumada
Clinical and virological features of chronic hepatitis C carriers with normal alanine aminotransferase levels despite positive serum HCV-RNA after interferon therapy.
Journal of gastroenterology 1999;34(5):594-9.
1999: Akihito Tsubota; Hiromitsu Kumada; Yasuji Arase; Kazuaki Chayama; Satoshi Saitoh; Kenji Ikeda; Masahiro Kobayashi; Yoshiyuki Suzuki; N Murashima
Combined ursodeoxycholic acid and glycyrrhizin therapy for chronic hepatitis C virus infection: a randomized controlled trial in 170 patients.
European journal of gastroenterology & hepatology 1999;11(10):1077-83.
1999: M Hashimoto; Kazuaki Chayama; Masahiro Kobayashi; Akihito Tsubota; Yasuji Arase; Satoshi Saitoh; Yoshiyuki Suzuki; Kenji Ikeda; M Matsuda; H Koike; M Kobayashi; H Handa; Hiromitsu Kumada
Fluctuations of hepatitis C virus load are not related to amino acid substitutions in hypervariable region 1 and interferon sensitivity determining region.
Journal of medical virology 1999;58(3):247-55.
1999: Yasuji Arase; Kenji Ikeda; Kazuaki Chayama; N Murashima; Akihito Tsubota; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; M Kobayashi; M Kobayashi; Hiromitsu Kumada
Efficacy and changes of the nonstructural 5A GENE by prolonged interferon therapy for patients with hepatitis C virus genotype 1b and a high level of serum HCV-RNA.
Internal medicine (Tokyo, Japan) 1999;38(6):461-6.
1999: Masahiro Kobayashi; Kazuaki Chayama; Yasuji Arase; M Kobayashi; Akihito Tsubota; Yoshiyuki Suzuki; I Koida; Satoshi Saitoh; N Murashima; Kenji Ikeda; H Koike; M Hashimoto; M Kobayashi; Hiromitsu Kumada
Prevalence of TT virus before and after blood transfusion in patients with chronic liver disease treated surgically for hepatocellular carcinoma.
Journal of gastroenterology and hepatology 1999;14(4):358-63.
1999: Kenji Ikeda; Satoshi Saitoh; Yasuji Arase; Kazuaki Chayama; Yoshiyuki Suzuki; Masahiro Kobayashi; Akihito Tsubota; I Nakamura; N Murashima; Hiromitsu Kumada; M Kawanishi
Effect of interferon therapy on hepatocellular carcinogenesis in patients with chronic hepatitis type C: A long-term observation study of 1,643 patients using statistical bias correction with proportional hazard analysis.
Hepatology (Baltimore, Md.) 1999;29(4):1124-30.
1999: Kazuaki Chayama; Masahiro Kobayashi; Akihito Tsubota; M Kobayashi; Yasuji Arase; Yoshiyuki Suzuki; Satoshi Saitoh; N Murashima; Kenji Ikeda; K Okamoto; M Hashimoto; M Matsuda; H Koike; M Kobayashi; Hiromitsu Kumada
Susceptibility of TT virus to interferon therapy.
The Journal of general virology 1999;80 ( Pt 3)():631-4.
1999: Y Hoshida; Kenji Ikeda; S Saito; Masahiro Kobayashi; M Kobayashi; Yoshiyuki Suzuki; Akihito Tsubota; I Koida; Yasuji Arase; N Murashima; Kazuaki Chayama; Hiromitsu Kumada
[The efficacy and prognosis of transcatheter chemoembolization for hepatocellular carcinoma in the elderly].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 1999;96(2):142-6.
1999: Y Arase; Hiromitsu Kumada
[Hepatitis D].
Ryōikibetsu shōkōgun shirīzu 1999;(23 Pt 1):59-61.
1999: K Chayama; Hiromitsu Kumada
[Hepatitis C virus infection].
Ryōikibetsu shōkōgun shirīzu 1999;(23 Pt 1):55-8.
1998: Kenji Ikeda; Satoshi Saitoh; Yoshiyuki Suzuki; Masahiro Kobayashi; Akihito Tsubota; I Koida; M Kobayashi; Yasuji Arase; Kazuaki Chayama; N Murashima; Hiromitsu Kumada
Relationship of angiographic finding with neovascular structure detected by immunohistochemical staining of alpha-smooth muscle actin in small hepatocellular carcinoma.
Journal of gastroenterology and hepatology 1998;13(12):1266-73.
1998: Akihito Tsubota; Hiromitsu Kumada; K Takaki; Kazuaki Chayama; Masahiro Kobayashi; M Kobayashi; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; N Murashima; Kenji Ikeda
Deletions in the hepatitis B virus core gene may influence the clinical outcome in hepatitis B e antigen-positive asymptomatic healthy carriers.
Journal of medical virology 1998;56(4):287-93.
1998: Yasuji Arase; Kenji Ikeda; N Murashima; Kazuaki Chayama; Akihito Tsubota; I Koida; Yoshiyuki Suzuki; Satoshi Saitoh; Masahiro Kobayashi; M Kobayashi; M Kobayashi; Hiromitsu Kumada
Glomerulonephritis in autopsy cases with hepatitis C virus infection.
Internal medicine (Tokyo, Japan) 1998;37(10):836-40.
1998: Masahiro Kobayashi; Kazuaki Chayama; M Fukuda; Akihito Tsubota; Yoshiyuki Suzuki; Yasuji Arase; I Koida; Satoshi Saitoh; N Murashima; Kenji Ikeda; H Koike; M Hashimoto; Y Miyano; M Kobayashi; Hiromitsu Kumada
Biochemical and histological features of hepatitis G virus infection.
Journal of gastroenterology and hepatology 1998;13(8):767-72.
1998: Kenji Ikeda; Satoshi Saitoh; Yoshiyuki Suzuki; Masahiro Kobayashi; Akihito Tsubota; I Koida; Yasuji Arase; M Fukuda; Kazuaki Chayama; N Murashima; Hiromitsu Kumada
Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2215 patients.
Journal of hepatology 1998;28(6):930-8.
1998: Kazuaki Chayama; Yoshiyuki Suzuki; Masahiro Kobayashi; M Kobayashi; Akihito Tsubota; M Hashimoto; Y Miyano; H Koike; M Kobayashi; I Koida; Yasuji Arase; Satoshi Saitoh; N Murashima; Kenji Ikeda; Hiromitsu Kumada
Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy.
Hepatology (Baltimore, Md.) 1998;27(6):1711-6.
1998: Kenji Ikeda; Hiromitsu Kumada; S Saitoh; Y Suzuki; M Kobayashi; Akihito Tsubota; I Koida; M Fukuda; Yasuji Arase; K Chayama; N Murashima; T Tango
A randomized controlled trial of interferon-alpha in patients with cirrhosis caused by 2a/2b genotype hepatitis C virus.
Journal of hepatology 1998;28(5):910-1.
1998: M Fukuda; Kazuaki Chayama; Akihito Tsubota; Masahiro Kobayashi; M Hashimoto; Y Miyano; H Koike; M Kobayashi; I Koida; Yasuji Arase; Satoshi Saitoh; N Murashima; Kenji Ikeda; Hiromitsu Kumada
Predictive factors in eradicating hepatitis C virus using a relatively small dose of interferon.
Journal of gastroenterology and hepatology 1998;13(4):412-8.
1998: Masahiro Kobayashi; Hiromitsu Kumada; Yasuji Arase; Kazuaki Chayama; M Kobayashi; Akihito Tsubota; I Koida; Satoshi Saitoh; Yoshiyuki Suzuki; N Murashima; Kenji Ikeda; Y Miyano; K Mizoshita; M Matsuda; H Koike; M Hashimoto
Usefulness of hepatitis C virus RNA counts by second generation HCV bDNA-probe in chronic hepatitis C based on the HCV genotype.
Journal of gastroenterology 1998;33(2):223-8.
1998: Kenji Ikeda; Satoshi Saitoh; Yoshiyuki Suzuki; Masahiro Kobayashi; Akihito Tsubota; M Fukuda; I Koida; Yasuji Arase; Kazuaki Chayama; N Murashima; Hiromitsu Kumada
Interferon decreases hepatocellular carcinogenesis in patients with cirrhosis caused by the hepatitis B virus: a pilot study.
Cancer 1998;82(5):827-35.
1997: Kenji Ikeda; Satoshi Saitoh; Yoshiyuki Suzuki; Akihito Tsubota; I Koida; Masahiro Kobayashi; Yasuji Arase; Kazuaki Chayama; N Murashima; Hiromitsu Kumada
Effect of arterial administration of a high molecular weight anti-tumor agent, styrene maleic acid neocarzinostatin, for multiple small liver cancer--a pilot study.
Journal of gastroenterology 1997;32(4):513-20.
1997: Akihito Tsubota; Hiromitsu Kumada; Kazuaki Chayama; Yasuji Arase; Satoshi Saitoh; I Koida; Yoshiyuki Suzuki; Masahiro Kobayashi; N Murashima; Kenji Ikeda
Time course of histological changes in patients with a sustained biochemical and virological response to interferon-alpha therapy for chronic hepatitis C virus infection.
Journal of hepatology 1997;27(1):49-55.
1997: Yasuji Arase; Kenji Ikeda; N Murashima; K Chayama; Akihito Tsubota; I Koida; Y Suzuki; S Saitoh; M Kobayashi; Hiromitsu Kumada
The long term efficacy of glycyrrhizin in chronic hepatitis C patients.
Cancer 1997;79(8):1494-500.
1997: Kenji Ikeda; S Saitoh; Y Suzuki; I Koida; Akihito Tsubota; M Kobayashi; Yasuji Arase; K Chayama; N Murashima; Hiromitsu Kumada
A prospective randomized administration of 5'-deoxy-5-fluorouridine as adjuvant chemotherapy for hepatocellular carcinoma treated with transcatheter arterial chemoembolization.
American journal of clinical oncology 1997;20(2):202-8.
1997: T Nakamura; Satoshi Saitoh; Kenji Ikeda; Masahiro Kobayashi; Yoshiyuki Suzuki; Akihito Tsubota; I Koida; Yasuji Arase; Kazuaki Chayama; N Murashima; Hiromitsu Kumada
[Cranial MRI in the patients with chronic liver disease (CLD)].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 1997;94(3):157-62.
1997: Kazuaki Chayama; Akihito Tsubota; Masahiro Kobayashi; K Okamoto; M Hashimoto; Y Miyano; H Koike; M Kobayashi; I Koida; Yasuji Arase; Satoshi Saitoh; Yoshiyuki Suzuki; N Murashima; Kenji Ikeda; Hiromitsu Kumada
Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype 1b hepatitis C virus infection.
Hepatology (Baltimore, Md.) 1997;25(3):745-9.