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Suresh Kumar

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Dharminder Chauhan; Mariaterresa Fulcinniti; Teru Hideshima; Benedikt M Kessler; William D Kingsbury; Matthew P Kodrasov; K G Suresh Kumar; Craig A Leach; Jeffrey L McDermott; Stephane Minvielle; Nikhil Munshi; Benjamin Nicholson; Robert Orlowski; Paul Richardson; Parantu K Shah; Ze Tian; Joseph Weinstock; Bin Zhou; Mikael Altun; Ruben Carrasco; Kenneth C Anderson
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Mikael Altun; Grigory L Dianov; Roman Fischer; Seth J Goldenberg; Svetlana V Khoronenkova; Edward Kogan; Rebecca Konietzny; Holger B Kramer; K G Suresh Kumar; Craig A Leach; Mukram M Mackeen; Jeffrey L McDermott; Joanna McGouran; Benjamin Nicholson; Jason L Parsons; Lianne I Willems; Benedikt M Kessler
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Jianghuai Liu; Lucas P Carvalho; Sabyasachi Bhattacharya; Christopher J Carbone; K G Suresh Kumar; N Adrian Leu; Peter M Yau; Robert G K Donald; Mitchell J Weiss; Darren P Baker; K John McLaughlin; Phillip Scott; Serge Y Fuchs
Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.

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All Publications

2012: Dharminder Chauhan; Mariaterresa Fulcinniti; Teru Hideshima; Benedikt M Kessler; William D Kingsbury; Matthew P Kodrasov; K G Suresh Kumar; Craig A Leach; Jeffrey L McDermott; Stephane Minvielle; Nikhil Munshi; Benjamin Nicholson; Robert Orlowski; Paul Richardson; Parantu K Shah; Ze Tian; Joseph Weinstock; Bin Zhou; Mikael Altun; Ruben Carrasco; Kenneth C Anderson
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Cancer cell 2012;22(3):345-58.
2011: Mikael Altun; Grigory L Dianov; Roman Fischer; Seth J Goldenberg; Svetlana V Khoronenkova; Edward Kogan; Rebecca Konietzny; Holger B Kramer; K G Suresh Kumar; Craig A Leach; Mukram M Mackeen; Jeffrey L McDermott; Joanna McGouran; Benjamin Nicholson; Jason L Parsons; Lianne I Willems; Benedikt M Kessler
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Chemistry & biology 2011;18(11):1401-12.
2009: Jianghuai Liu; Lucas P Carvalho; Sabyasachi Bhattacharya; Christopher J Carbone; K G Suresh Kumar; N Adrian Leu; Peter M Yau; Robert G K Donald; Mitchell J Weiss; Darren P Baker; K John McLaughlin; Phillip Scott; Serge Y Fuchs
Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling.
Molecular and cellular biology 2009;29(24):6401-12.
2009: Jianghuai Liu; Wei-Chun HuangFu; K G Suresh Kumar; Juan Qian; James P Casey; Robert B Hamanaka; Christina Grigoriadou; Rafael Aldabe; J Alan Diehl; Serge Y Fuchs
Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor.
Cell host & microbe 2009;5(1):72-83.
2008: K G Suresh Kumar; Bentley Varghese; Anamika Banerjee; Darren P Baker; Stefan N Constantinescu; Sandra Pellegrini; Serge Y Fuchs
Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif.
The Journal of biological chemistry 2008;283(27):18566-72.
2008: Gayathri Swaminathan; Bentley Varghese; Chellappagounder Thangavel; Christopher J Carbone; Alexander Plotnikov; K G Suresh Kumar; Elizabeth M Jablonski; Charles V Clevenger; Vincent Goffin; Luqin Deng; Stuart J Frank; Serge Y Fuchs
Prolactin stimulates ubiquitination, initial internalization, and degradation of its receptor via catalytic activation of Janus kinase 2.
The Journal of endocrinology 2008;196(2):R1-7.
2007: K G Suresh Kumar; Herve Barriere; Christopher J Carbone; Jianghuai Liu; Gayathri Swaminathan; Ping Xu; Ying Li; Darren P Baker; Junmin Peng; Gergely L Lukacs; Serge Y Fuchs
Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis.
The Journal of cell biology 2007;179(5):935-50.
2007: K G Suresh Kumar; Jianghuai Liu; Ying Li; Duonan Yu; Andrei Thomas-Tikhonenko; Meenhard Herlyn; Serge Y Fuchs
Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells.
Cancer biology & therapy 2007;6(9):1437-41.
2006: Douglas I Lin; Olena Barbash; K G Suresh Kumar; Jason D. Weber; J Wade Harper; Andres J P Klein-Szanto; Anil K Rustgi; Serge Y Fuchs; J Alan Diehl
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex.
Molecular cell 2006;24(3):355-66.
2006: Zrinka Marijanovic; Josiane Ragimbeau; K G Suresh Kumar; Serge Y Fuchs; Sandra Pellegrini
TYK2 activity promotes ligand-induced IFNAR1 proteolysis.
The Biochemical journal 2006;397(1):31-8.
2006: Oxana A Malakhova; Keun Il Kim; Jiann-Kae Luo; Weiguo Zou; K G Suresh Kumar; Serge Y Fuchs; Ke Shuai; Dong-Er Zhang
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity.
The EMBO journal 2006;25(11):2358-67.
2006: Yiwen Li; Charles V Clevenger; N Minkovsky; K G Suresh Kumar; Puthiyaveettil N Raghunath; John E Tomaszewski; Vladimir S Spiegelman; Serge Y Fuchs
Stabilization of prolactin receptor in breast cancer cells.
Oncogene 2006;25(13):1896-902.
2004: K G Suresh Kumar; John J Krolewski; Serge Y Fuchs
Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor.
The Journal of biological chemistry 2004;279(45):46614-20.
2004: K G Suresh Kumar; Rajesh Ullanat; Chelliah Jayabaskaran
Molecular cloning, characterization, tissue-specific and phytohormone-induced expression of calcium-dependent protein kinase gene in cucumber (Cucumis sativus L.).
Journal of plant physiology 2004;161(9):1061-71.
2004: K G Suresh Kumar; Chelliah Jayabaskaran
Variations in the level of enzyme activity and immunolocalization of calcium-dependent protein kinases in the phloem of different cucumber organs.
Journal of plant physiology 2004;161(8):889-901.
2004: Ying Li; K G Suresh Kumar; Weigang Tang; Vladimir S Spiegelman; Serge Y Fuchs
Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase.
Molecular and cellular biology 2004;24(9):4038-48.
2004: Serge Y Fuchs; Vladimir S Spiegelman; K G Suresh Kumar
The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer.
Oncogene 2004;23(11):2028-36.
2003: K G Suresh Kumar; Weigang Tang; Abhilash K Ravindranath; William A Clark; Ed Croze; Serge Y Fuchs
SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor.
The EMBO journal 2003;22(20):5480-90.