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Sharad Kumar
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Network (preview)
16
Cook, David
12
Dorstyn, Loretta
11
Daish, Tasman
11
Dinudom, Anuwat
11
Mills, Kathryn
9
Cakouros, Dimitrios
8
Colussi, Paul
8
Harvey, NL
8
Harvey, KF
7
Read, Stuart
7
Richardson, Helena
7
Fotia, Andrew
6
Quinn, LM
5
Poronnik, Philip
5
Young, John
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All Publications
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2009: Howitt Jason; Putz Ulrich; Lackovic Jenny; Doan Anh; Dorstyn Loretta; Cheng Hong; Yang Baoli; Chan-Ling Tailoi; Silke John; Kumar Sharad; Tan Seong-Seng
Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(36):15489-94.
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2009: Lee Il-Ha; Campbell Craig R; Song Sung-Hee; Day Margot L; Kumar Sharad; Cook David I; Dinudom Anuwat
The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism.
The Journal of biological chemistry 2009;284(19):12663-9.
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2009: Kochetkova M; Kumar S; McColl S R
Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells.
Cell death and differentiation 2009;16(5):664-73.
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2009: Ho Lien Ha; Taylor Robyn; Dorstyn Loretta; Cakouros Dimitrios; Bouillet Philippe; Kumar Sharad
A tumor suppressor function for caspase-2.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5336-41.
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2009: Kumar Sharad; Dorstyn Loretta
Analysing caspase activation and caspase activity in apoptotic cells.
Methods in molecular biology (Clifton, N.J.) 2009;559():3-17.
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2008: Foot Natalie J; Dalton Hazel E; Shearwin-Whyatt Linda M; Dorstyn Loretta; Tan Seong-Seng; Yang Baoli; Kumar Sharad
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.
Blood 2008;112(10):4268-75.
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2008: Cakouros Dimitrios; Mills Kathryn; Denton Donna; Paterson Alicia; Daish Tasman; Kumar Sharad
dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes.
The Journal of cell biology 2008;182(3):481-95.
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2008: He Yaowu; Hryciw Deanne H; Carroll Melanie L; Myers Stephen A; Whitbread Astrid K; Kumar Sharad; Poronnik Philip; Hooper John D
The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels.
The Journal of biological chemistry 2008;283(35):24000-10.
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2008: Hiwase Devendra K; Saunders Verity; Hewett Duncan; Frede Amity; Zrim Stephanie; Dang Phuong; Eadie Laura; To L Bik; Melo Junia; Kumar Sharad; Hughes Timothy P; White Deborah L
Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(12):3881-8.
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2008: Manning Jantina A; Colussi Paul A; Koblar Simon A; Kumar Sharad
Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development.
Histochemistry and cell biology 2008;129(6):751-64.
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2008: Denton Donna; Mills Kathryn; Kumar Sharad
Methods and protocols for studying cell death in Drosophila.
Methods in enzymology 2008;446():17-37.
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2007: Dibbens L M; Ekberg J; Taylor I; Hodgson B L; Conroy S-J; Lensink I L; Kumar S; Zielinski M A; Harkin L A; Sutherland G R; Adams D J; Berkovic S F; Scheffer I E; Mulley J C; Poronnik P
NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity.
Genes, brain, and behavior 2007;6(8):750-5.
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2007: Lee Il-Ha; Dinudom Anuwat; Sanchez-Perez Angeles; Kumar Sharad; Cook David I
Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2.
The Journal of biological chemistry 2007;282(41):29866-73.
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2007: Sanchez-Perez Angeles; Kumar Sharad; Cook David I
GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.
Biochemical and biophysical research communications 2007;359(3):611-5.
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2007: Doumanis J; Dorstyn L; Kumar S
Molecular determinants of the subcellular localization of the Drosophila Bcl-2 homologues DEBCL and BUFFY.
Cell death and differentiation 2007;14(5):907-15.
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2007: Ekberg Jenny; Schuetz Friderike; Boase Natasha A; Conroy Sarah-Jane; Manning Jantina; Kumar Sharad; Poronnik Philip; Adams David J
Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2.
The Journal of biological chemistry 2007;282(16):12135-42.
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2007: Kumar S
Caspase function in programmed cell death.
Cell death and differentiation 2007;14(1):32-43.
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2007: Manning Jantina; Kumar Sharad
NEDD1: function in microtubule nucleation, spindle assembly and beyond.
The international journal of biochemistry & cell biology 2007;39(1):7-11.
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2006: Rauh Robert; Dinudom Anuwat; Fotia Andrew B; Paulides Marios; Kumar Sharad; Korbmacher Christoph; Cook David I
Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition.
Pflügers Archiv : European journal of physiology 2006;452(3):290-9.
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2006: Mills Kathryn; Daish Tasman; Harvey Kieran F; Pfleger Cathie M; Hariharan Iswar K; Kumar Sharad
The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death.
The Journal of cell biology 2006;172(6):809-15.
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2006: Fotia Andrew B; Cook David I; Kumar Sharad
The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities.
The international journal of biochemistry & cell biology 2006;38(3):472-9.
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2005: Mills Kathryn; Daish Tasman; Kumar Sharad
The function of the Drosophila caspase DRONC in cell death and development.
Cell cycle (Georgetown, Tex.) 2005;4(6):744-6.
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2005: Kilpatrick Zoé E; Cakouros Dimitrios; Kumar Sharad
Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells.
The Journal of biological chemistry 2005;280(12):11981-6.
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2004: Daish Tasman J; Mills Kathryn; Kumar Sharad
Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis.
Developmental cell 2004;7(6):909-15.
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2004: Chew Su Kit; Akdemir Fatih; Chen Po; Lu Wan-Jin; Mills Kathryn; Daish Tasman; Kumar Sharad; Rodriguez Antony; Abrams John M
The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila.
Developmental cell 2004;7(6):897-907.
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2004: Hryciw Deanne H; Ekberg Jenny; Lee Aven; Lensink Ingrid L; Kumar Sharad; Guggino William B; Cook David I; Pollock Carol A; Poronnik Philip
Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells.
The Journal of biological chemistry 2004;279(53):54996-5007.
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2004: Dorstyn Loretta; Mills Kathryn; Lazebnik Yuri; Kumar Sharad
The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells.
The Journal of cell biology 2004;167(3):405-10.
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2004: Baliga B C; Read S H; Kumar S
The biochemical mechanism of caspase-2 activation.
Cell death and differentiation 2004;11(11):1234-41.
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2004: Kumar Sharad
Migrate, differentiate, proliferate, or die: pleiotropic functions of an apical "apoptotic caspase".
Science's STKE : signal transduction knowledge environment 2004;2004(254):pe49.
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2004: Dinudom Anuwat; Fotia Andrew B; Lefkowitz Robert J; Young John A; Kumar Sharad; Cook David I
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11886-90.
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2004: Shearwin-Whyatt Linda M; Brown Darren L; Wylie Fiona G; Stow Jennifer L; Kumar Sharad
N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.
Journal of cell science 2004;117(Pt 16):3679-89.
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2004: Fotia Andrew B; Ekberg Jenny; Adams David J; Cook David I; Poronnik Philip; Kumar Sharad
Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.
The Journal of biological chemistry 2004;279(28):28930-5.
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2004: Ekert Paul G; Read Stuart H; Silke John; Marsden Vanessa S; Kaufmann Hitto; Hawkins Christine J; Gerl Robert; Kumar Sharad; Vaux David L
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die.
The Journal of cell biology 2004;165(6):835-42.
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2004: Cakouros Dimitrios; Daish Tasman J; Kumar Sharad
Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues.
The Journal of cell biology 2004;165(5):631-40.
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2004: Kumar Sharad; Cakouros Dimitrios
Transcriptional control of the core cell-death machinery.
Trends in biochemical sciences 2004;29(4):193-9.
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2004: Cakouros Dimitrios; Daish Tasman J; Mills Kathryn; Kumar Sharad
An arginine-histone methyltransferase, CARMER, coordinates ecdysone-mediated apoptosis in Drosophila cells.
The Journal of biological chemistry 2004;279(18):18467-71.
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2004: Kumar Sharad
Measurement of caspase activity in cells undergoing apoptosis.
Methods in molecular biology (Clifton, N.J.) 2004;282():19-30.
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2003: Daish T J; Cakouros D; Kumar S
Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc.
Cell death and differentiation 2003;10(12):1348-56.
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2003: Quinn Leonie; Coombe Michelle; Mills Kathryn; Daish Tasman; Colussi Paul; Kumar Sharad; Richardson Helena
Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions.
The EMBO journal 2003;22(14):3568-79.
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2003: Baliga Belinda C; Colussi Paul A; Read Stuart H; Dias Manisha M; Jans David A; Kumar Sharad
Role of prodomain in importin-mediated nuclear localization and activation of caspase-2.
The Journal of biological chemistry 2003;278(7):4899-905.
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2003: Fotia Andrew B; Dinudom Anuwat; Shearwin Keith E; Koch Jan-Peter; Korbmacher Christoph; Cook David I; Kumar Sharad
The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):70-2.
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2002: Read Stuart H; Baliga Belinda C; Ekert Paul G; Vaux David L; Kumar Sharad
A novel Apaf-1-independent putative caspase-2 activation complex.
The Journal of cell biology 2002;159(5):739-45.
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2002: Kumar Sharad; Vaux David L
Apoptosis. A cinderella caspase takes center stage.
Science (New York, N.Y.) 2002;297(5585):1290-1.
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2002: O'Reilly L A; Ekert P; Harvey N; Marsden V; Cullen L; Vaux D L; Hacker G; Magnusson C; Pakusch M; Cecconi F; Kuida K; Strasser A; Huang D C S; Kumar S
Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9.
Cell death and differentiation 2002;9(8):832-41.
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2002: Konstas Angelos-Aristeidis; Shearwin-Whyatt Linda M; Fotia Andrew B; Degger Brian; Riccardi Daniela; Cook David I; Korbmacher Christoph; Kumar Sharad
Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.
The Journal of biological chemistry 2002;277(33):29406-16.
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2002: Cakouros Dimitrios; Daish Tasman; Martin Damali; Baehrecke Eric H; Kumar Sharad
Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex.
The Journal of cell biology 2002;157(6):985-95.
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2002: Dorstyn Loretta; Read Stuart; Cakouros Dimitrios; Huh Jun R; Hay Bruce A; Kumar Sharad
The role of cytochrome c in caspase activation in Drosophila melanogaster cells.
The Journal of cell biology 2002;156(6):1089-98.
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2002: Harvey Kieran F; Shearwin-Whyatt Linda M; Fotia Andrew; Parton Robert G; Kumar Sharad
N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.
The Journal of biological chemistry 2002;277(11):9307-17.
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2002: Cook David I; Dinudom Anuwat; Komwatana Permsak; Kumar Sharad; Young John A
Patch-clamp studies on epithelial sodium channels in salivary duct cells.
Cell biochemistry and biophysics 2002;36(2-3):105-13.
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2001: Harvey N L; Daish T; Mills K; Dorstyn L; Quinn L M; Read S H; Richardson H; Kumar S
Characterization of the Drosophila caspase, DAMM.
The Journal of biological chemistry 2001;276(27):25342-50.
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2001: Doumanis J; Quinn L; Richardson H; Kumar S
STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2.
Cell death and differentiation 2001;8(4):387-94.
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2001: Shearwin-Whyatt L; Baliga B; Doumanis J; Kumar S
Chimeric caspase molecules with potent cell killing activity in apoptosis-resistant cells.
Biochemical and biophysical research communications 2001;282(5):1114-9.
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2001: Dinudom A; Harvey K F; Komwatana P; Jolliffe C N; Young J A; Kumar S; Cook D I
Roles of the C termini of alpha -, beta -, and gamma -subunits of epithelial Na+ channels (ENaC) in regulating ENaC and mediating its inhibition by cytosolic Na+.
The Journal of biological chemistry 2001;276(17):13744-9.
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2001: Harvey K F; Dinudom A; Cook D I; Kumar S
The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.
The Journal of biological chemistry 2001;276(11):8597-601.
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2000: Quinn L M; Dorstyn L; Mills K; Colussi P A; Chen P; Coombe M; Abrams J; Kumar S; Richardson H
An essential role for the caspase dronc in developmentally programmed cell death in Drosophila.
The Journal of biological chemistry 2000;275(51):40416-24.
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2000: Kumar S; Doumanis J
The fly caspases.
Cell death and differentiation 2000;7(11):1039-44.
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2000: Jolliffe C N; Harvey K F; Haines B P; Parasivam G; Kumar S
Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4.
The Biochemical journal 2000;351 Pt 3():557-65.
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2000: Shearwin-Whyatt L M; Harvey N L; Kumar S
Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD.
Cell death and differentiation 2000;7(2):155-65.
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2000: Colussi P A; Quinn L M; Huang D C; Coombe M; Read S H; Richardson H; Kumar S
Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery.
The Journal of cell biology 2000;148(4):703-14.
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1999: Kumar S
Mechanisms mediating caspase activation in cell death.
Cell death and differentiation 1999;6(11):1060-6.
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1999: Dorstyn L; Read S H; Quinn L M; Richardson H; Kumar S
DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7.
The Journal of biological chemistry 1999;274(43):30778-83.
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1999: Shearwin-Whyatt L M; Kumar S
Caspases in developmental cell death.
IUBMB life 1999;48(2):143-50.
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1999: Ishibashi H; Dinudom A; Harvey K F; Kumar S; Young J A; Cook D I
Na(+)-H(+) exchange in salivary secretory cells is controlled by an intracellular Na(+) receptor.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9949-53.
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1999: Harvey K F; Kumar S
Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions.
Trends in cell biology 1999;9(5):166-9.
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1999: Harvey K F; Dinudom A; Komwatana P; Jolliffe C N; Day M L; Parasivam G; Cook D I; Kumar S
All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+.
The Journal of biological chemistry 1999;274(18):12525-30.
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1999: Dorstyn L; Colussi P A; Quinn L M; Richardson H; Kumar S
DRONC, an ecdysone-inducible Drosophila caspase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4307-12.
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1999: Colussi P A; Kumar S
Targeted disruption of caspase genes in mice: what they tell us about the functions of individual caspases in apoptosis.
Immunology and cell biology 1999;77(1):58-63.
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1999: Kumar S; Colussi P A
Prodomains--adaptors--oligomerization: the pursuit of caspase activation in apoptosis.
Trends in biochemical sciences 1999;24(1):1-4.
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1998: Colussi P A; Harvey N L; Shearwin-Whyatt L M; Kumar S
Conversion of procaspase-3 to an autoactivating caspase by fusion to the caspase-2 prodomain.
The Journal of biological chemistry 1998;273(41):26566-70.
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1998: Colussi P A; Harvey N L; Kumar S
Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor. A novel function for a caspase prodomain.
The Journal of biological chemistry 1998;273(38):24535-42.
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1998: Dinudom A; Harvey K F; Komwatana P; Young J A; Kumar S; Cook D I
Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosolic Na+.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):7169-73.
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1998: Harvey K F; Harvey N L; Michael J M; Parasivam G; Waterhouse N; Alnemri E S; Watters D; Kumar S
Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis.
The Journal of biological chemistry 1998;273(22):13524-30.
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1998: Butt A J; Harvey N L; Parasivam G; Kumar S
Dimerization and autoprocessing of the Nedd2 (caspase-2) precursor requires both the prodomain and the carboxyl-terminal regions.
The Journal of biological chemistry 1998;273(12):6763-8.
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1998: Dorstyn L; Kinoshita M; Kumar S
Caspases in cell death.
Results and problems in cell differentiation 1998;24():1-24.
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1997: Dorstyn L; Kumar S
Differential inhibitory effects of CrmA, P35, IAP and three mammalian IAP homologues on apoptosis in NIH3T3 cells following various death stimuli.
Cell death and differentiation 1997;4(7):570-9.
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1997: Harvey N L; Butt A J; Kumar S
Functional activation of Nedd2/ICH-1 (caspase-2) is an early process in apoptosis.
The Journal of biological chemistry 1997;272(20):13134-9.
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1997: Kumar S
The apoptotic cysteine protease CPP32.
The international journal of biochemistry & cell biology 1997;29(3):393-6.
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1996: Waterhouse N; Kumar S; Song Q; Strike P; Sparrow L; Dreyfuss G; Alnemri E S; Litwack G; Lavin M; Watters D
Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin 1beta-converting enzyme-like proteases in apoptosis.
The Journal of biological chemistry 1996;271(46):29335-41.
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1996: Song Q; Burrows S R; Smith G; Lees-Miller S P; Kumar S; Chan D W; Trapani J A; Alnemri E; Litwack G; Lu H; Moss D J; Jackson S; Lavin M F
Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.
The Journal of experimental medicine 1996;184(2):619-26.
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1996: Harvey N L; Trapani J A; Fernandes-Alnemri T; Litwack G; Alnemri E S; Kumar S
Processing of the Nedd2 precursor by ICE-like proteases and granzyme B.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(7):673-85.
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1996: Song Q; Lees-Miller S P; Kumar S; Zhang Z; Chan D W; Smith G C; Jackson S P; Alnemri E S; Litwack G; Khanna K K; Lavin M F
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.
The EMBO journal 1996;15(13):3238-46.
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1995: Kumar S; Harvey N L
Role of multiple cellular proteases in the execution of programmed cell death.
FEBS letters 1995;375(3):169-73.
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1995: Kumar S
Inhibition of apoptosis by the expression of antisense Nedd2.
FEBS letters 1995;368(1):69-72.
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1995: Kumar S; White D L; Takai S; Turczynowicz S; Juttner C A; Hughes T P
Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms.
Human genetics 1995;95(6):641-4.
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