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Santosh Kumar

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Santosh Kumar; Yonghong Zhao; Ling Sun; Surendra S Negi; James Halpert; BK Muralidhara
Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.
Yonghong Zhao; Ling Sun; BK Muralidhara; Santosh Kumar; Mark A White; C David Stout; James Halpert
Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.
Santosh Kumar
Identification of a novel laser dye substrate of mammalian cytochromes P450: application in rapid kinetic analysis, inhibitor screening, and directed evolution.

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2007: Santosh Kumar; Yonghong Zhao; Ling Sun; Surendra S Negi; James Halpert; BK Muralidhara
Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.
Molecular pharmacology 2007;72(5):1191-9.
2007: Yonghong Zhao; Ling Sun; BK Muralidhara; Santosh Kumar; Mark A White; C David Stout; James Halpert
Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.
Biochemistry 2007;46(41):11559-67.
2007: Santosh Kumar
Identification of a novel laser dye substrate of mammalian cytochromes P450: application in rapid kinetic analysis, inhibitor screening, and directed evolution.
Journal of biomolecular screening 2007;12(5):677-82.
2007: Ling Sun; Chong S Chen; David J Waxman; Hong Liu; James Halpert; Santosh Kumar
Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.
Archives of biochemistry and biophysics 2007;458(2):167-74.
2006: Santosh Kumar; Ling Sun; Hong Liu; BK Muralidhara; James Halpert
Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide.
Protein engineering, design & selection : PEDS 2006;19(12):547-54.
2006: Santosh Kumar; Hong Liu; James Halpert
Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(12):1958-65.
2006: Cynthia E Hernandez; Santosh Kumar; Hong Liu; James Halpert
Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme.
Archives of biochemistry and biophysics 2006;455(1):61-7.
2005: Santosh Kumar; James Halpert
Use of directed evolution of mammalian cytochromes P450 for investigating the molecular basis of enzyme function and generating novel biocatalysts.
Biochemical and biophysical research communications 2005;338(1):456-64.
2005: Santosh Kumar; Dmitri Davydov; James Halpert
Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1131-6.
2005: Santosh Kumar; Chong S Chen; David J Waxman; James Halpert
Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide.
The Journal of biological chemistry 2005;280(20):19569-75.
2004: Dmitri Davydov; Alexandra E Botchkareva; Santosh Kumar; You Qun He; James Halpert
An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.
Biochemistry 2004;43(21):6475-85.
2003: Santosh Kumar; Emily E Scott; Hong Liu; James Halpert
A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.
The Journal of biological chemistry 2003;278(19):17178-84.
2002: Dmitri Davydov; Santosh Kumar; James Halpert
Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate.
Biochemical and biophysical research communications 2002;294(4):806-12.