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Kazuhiko Kume

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Martin Hegen; Linhong Sun; Naonori Uozumi; Kazuhiko Kume; Mary E Goad; Cheryl Nickerson-Nutter; Takao Shimizu; James D Clark
Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis.
Y Kawasawa; Kazuhiko Kume; Takashi Izumi; Takao Shimizu
Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems.
Y Kawasawa; Kazuhiko Kume; S Nakade; H Haga; Takashi Izumi; Takao Shimizu
Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45.

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All Publications

2003: Martin Hegen; Linhong Sun; Naonori Uozumi; Kazuhiko Kume; Mary E Goad; Cheryl Nickerson-Nutter; Takao Shimizu; James D Clark
Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis.
The Journal of experimental medicine 2003;197(10):1297-302.
2000: Y Kawasawa; Kazuhiko Kume; Takashi Izumi; Takao Shimizu
Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems.
Biochemical and biophysical research communications 2000;276(3):957-64.
2000: Y Kawasawa; Kazuhiko Kume; S Nakade; H Haga; Takashi Izumi; Takao Shimizu
Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45.
Biochemical and biophysical research communications 2000;276(3):952-6.
2000: Makoto Aihara; Satoshi Ishii; Kazuhiko Kume; Takao Shimizu
Interaction between neurone and microglia mediated by platelet-activating factor.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(5):397-406.
1999: Shinichi Sato; Kazuhiko Kume; C Ito; Satoshi Ishii; Takao Shimizu
Accelerated proliferation of epidermal keratinocytes by the transgenic expression of the platelet-activating factor receptor.
Archives of dermatological research 1999;291(11):614-21.
1999: Takashi Nagase; Satoshi Ishii; Kazuhiko Kume; Naonori Uozumi; Takashi Izumi; Yasuyoshi Ouchi; Takao Shimizu
Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice.
The Journal of clinical investigation 1999;104(8):1071-6.
1999: Katsunori Kobayashi; Satoshi Ishii; Kazuhiko Kume; Tomoyuki Takahashi; Takao Shimizu; Toshiya Manabe
Platelet-activating factor receptor is not required for long-term potentiation in the hippocampal CA1 region.
The European journal of neuroscience 1999;11(4):1313-6.
1999: Tetsuya Hirabayashi; Kazuhiko Kume; Kenzo Hirose; Takehiko Yokomizo; Masamitsu Iino; Hiroshi Itoh; Takao Shimizu
Critical duration of intracellular Ca2+ response required for continuous translocation and activation of cytosolic phospholipase A2.
The Journal of biological chemistry 1999;274(8):5163-9.
1998: Tetsuya Hirabayashi; Kazuhiko Kume; Takao Shimizu
Conditional expression of the dual-specificity phosphatase PYST1/MKP-3 inhibits phosphorylation of cytosolic phospholipase A2 in Chinese hamster ovary cells.
Biochemical and biophysical research communications 1998;253(2):485-8.
1998: S Kinoshita; Hiroshi Suzuki; Kousei Ito; Kazuhiko Kume; Takao Shimizu; Yuichi Sugiyama
Transfected rat cMOAT is functionally expressed on the apical membrane in Madin-Darby canine kidney (MDCK) cells.
Pharmaceutical research 1998;15(12):1851-6.
1998: Satoshi Ishii; Tomoyuki Kuwaki; Takashi Nagase; K Maki; F Tashiro; Shinji Sunaga; WH Cao; Kazuhiko Kume; Yoshinosuke Fukuchi; Kazuyoshi Ikuta; Jun-ichi Miyazaki; Mamoru Kumada; Takao Shimizu
Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor.
The Journal of experimental medicine 1998;187(11):1779-88.
1998: Kousei Ito; Hiroshi Suzuki; Tomoko Hirohashi; Kazuhiko Kume; Takao Shimizu; Yuichi Sugiyama
Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver.
The Journal of biological chemistry 1998;273(3):1684-8.
1997: Naonori Uozumi; Kazuhiko Kume; Takashi Nagase; N Nakatani; Satoshi Ishii; F Tashiro; Yoshinori Komagata; K Maki; Kazuyoshi Ikuta; Yasuyoshi Ouchi; Jun-ichi Miyazaki; Takao Shimizu
Role of cytosolic phospholipase A2 in allergic response and parturition.
Nature 1997;390(6660):618-22.
1997: S Tabuchi; Kazuhiko Kume; Makoto Aihara; Satoshi Ishii; Masayoshi Mishina; Takao Shimizu
Lipid mediators modulate NMDA receptor currents in a Xenopus oocyte expression system.
Neuroscience letters 1997;237(1):13-6.
1997: Kazuhiko Kume; Takao Shimizu
Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor.
The Journal of biological chemistry 1997;272(36):22898-904.
1997: Kazuhiko Kume; Takao Shimizu
cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase.
Biochemical and biophysical research communications 1997;237(3):663-6.
1997: Kazuhiko Kume; I Waga; Takao Shimizu
Microplate chromatography assay for acetyl-CoA: lysoplatelet-activating factor acetyltransferase.
Analytical biochemistry 1997;246(1):118-22.
1997: Satoshi Ishii; Takashi Nagase; F Tashiro; Kazuyoshi Ikuta; Shinichi Sato; I Waga; Kazuhiko Kume; Jun-ichi Miyazaki; Takao Shimizu
Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor.
The EMBO journal 1997;16(1):133-42.
1997: Masatomo Mori; Makoto Aihara; Kazuhiko Kume; M Hamanoue; S Kohsaka; Takao Shimizu
Localization of platelet-activating factor receptor in the rat brain.
Advances in experimental medicine and biology 1997;407():357-63.
1997: Satoshi Ishii; M Nakamura; I Waga; Kazuhiko Kume; Takashi Izumi; Takao Shimizu
Cloning and characterization of a murine platelet-activating factor receptor gene.
Advances in experimental medicine and biology 1997;407():347-55.
1997: Takehiko Yokomizo; Yoshihide Ogawa; N Uozumi; Kazuhiko Kume; Takashi Izumi; Takao Shimizu
cDNA cloning and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase.
Advances in experimental medicine and biology 1997;407():151-6.
1997: Kousei Ito; Hiroshi Suzuki; Tomoko Hirohashi; Kazuhiko Kume; Takao Shimizu; Yuichi Sugiyama
Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR.
The American journal of physiology 1997;272(1 Pt 1):G16-22.
1996: T Shimizu; Masatomo Mori; H Bito; C Sakanaka; S Tabuchi; Makoto Aihara; Kazuhiko Kume
Platelet-activating factor and somatostatin activate mitogen-activated protein kinase (MAP kinase) and arachidonate release.
Journal of lipid mediators and cell signalling 1996;14(1-3):103-8.
1996: Masatomo Mori; Makoto Aihara; Kazuhiko Kume; M Hamanoue; S Kohsaka; T Shimizu
Predominant expression of platelet-activating factor receptor in the rat brain microglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(11):3590-600.
1996: I M Ferby; iwao waga; M Hoshino; Kazuhiko Kume; T Shimizu
Wortmannin inhibits mitogen-activated protein kinase activation by platelet-activating factor through a mechanism independent of p85/p110-type phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1996;271(20):11684-8.
1996: iwao waga; Kazuhiko Kume; I Ferby; Zen-ichiro Honda; T Shimizu
Micro-trap phosphorylation assay of mitogen-activated protein (MAP) kinases to detect their activation by lipopolysaccharides.
Journal of immunological methods 1996;190(1):71-7.
1996: Satoshi Ishii; Y Matsuda; M Nakamura; iwao waga; Kazuhiko Kume; Takashi Izumi; T Shimizu
A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages.
The Biochemical journal 1996;314 ( Pt 2)():671-8.
1996: Takehiko Yokomizo; Y Ogawa; Naonori Uozumi; Kazuhiko Kume; Takashi Izumi; T Shimizu
cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase.
The Journal of biological chemistry 1996;271(5):2844-50.
1996: I Ferby; iwao waga; Kazuhiko Kume; C Sakanaka; T Shimizu
PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages.
Advances in experimental medicine and biology 1996;416():321-6.
1996: Shinichi Sato; Kazuhiko Kume; T Takan; H Mutoh; Y Taketani; T Shimizu
Up-regulation of the intracellular Ca2+ signaling and mRNA expression of platelet-activating factor receptor by estradiol in human uterine endometrial cells.
Advances in experimental medicine and biology 1996;416():95-100.
1995: Takehiko Yokomizo; Naonori Uozumi; T Takahashi; Kazuhiko Kume; Takashi Izumi; T Shimizu
Leukotriene A4 hydrolase and leukotriene B4 metabolism.
Journal of lipid mediators and cell signalling 1995;12(2-3):321-32.
1995: Takashi Izumi; Zen-ichiro Honda; H Mutoh; Kazuhiko Kume; T Shimizu
Regulation and signal transduction of PAF receptor.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():461-6.
1994: H Mutoh; Kazuhiko Kume; Shinichi Sato; Shigeaki Kato; T Shimizu
Positive and negative regulations of human platelet-activating factor receptor transcript 2 (tissue-type) by estrogen and TGF-beta 1.
Biochemical and biophysical research communications 1994;205(2):1130-6.
1994: I M Ferby; iwao waga; C Sakanaka; Kazuhiko Kume; T Shimizu
Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils.
The Journal of biological chemistry 1994;269(48):30485-8.
1994: Masatomo Mori; H Bito; C Sakanaka; Zen-ichiro Honda; Kazuhiko Kume; Takashi Izumi; T Shimizu
Activation of mitogen-activated protein kinase and arachidonate release via two G protein-coupled receptors expressed in the rat hippocampus.
Annals of the New York Academy of Sciences 1994;744():107-25.