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S Kume

Research Profile

Anatomy

Blood Platelets

Physiology

Chemicals & Drugs

Phenomena

Phosphorylation

Procedures

Platelet Function Tests

Co-author Network

Publications

TOP 3
Yutaka Yatomi; Tsukasa Ohmori; Ge Rile; F Kazama; H Okamoto; T Sano; Kaneo Satoh; S Kume; G Tigyi; Y Igarashi; Yoshio Ozaki
Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells.
N Hisano; Yutaka Yatomi; M A Fujino; Y Igarashi; S Kume; Yoshio Ozaki
Quantification of sphingosine derivatives in human platelets: inducible formation of free sphingosine.
Naoki Asazuma; Yoshio Ozaki; Kaneo Satoh; Yutaka Yatomi; M Handa; Y Fujimura; S Miura; S Kume
Glycoprotein Ib-von Willebrand factor interactions activate tyrosine kinases in human platelets.

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All Publications

2000: Yutaka Yatomi; Tsukasa Ohmori; Ge Rile; F Kazama; H Okamoto; T Sano; Kaneo Satoh; S Kume; G Tigyi; Y Igarashi; Yoshio Ozaki
Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells.
Blood 2000;96(10):3431-8.
1998: N Hisano; Yutaka Yatomi; M A Fujino; Y Igarashi; S Kume; Yoshio Ozaki
Quantification of sphingosine derivatives in human platelets: inducible formation of free sphingosine.
Journal of biochemistry 1998;123(2):263-8.
1997: Naoki Asazuma; Yoshio Ozaki; Kaneo Satoh; Yutaka Yatomi; M Handa; Y Fujimura; S Miura; S Kume
Glycoprotein Ib-von Willebrand factor interactions activate tyrosine kinases in human platelets.
Blood 1997;90(12):4789-98.
1997: Yutaka Yatomi; S Yamamura; F Ruan; S Kume; Yoshio Ozaki; Y Igarashi
N,N-dimethylsphingosine 1-phosphate activates human platelets.
FEBS letters 1997;417(3):341-4.
1997: Yutaka Yatomi; Y Igarashi; L Yang; N Hisano; R Qi; Naoki Asazuma; Kaneo Satoh; Yoshio Ozaki; S Kume
Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum.
Journal of biochemistry 1997;121(5):969-73.
1997: Yutaka Yatomi; S Kume
[The measurement of platelet life span].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl 1():113-6.
1997: S Kume
[Evaluation and problems on platelet function tests].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl 1():94-101.
1997: M Yanabu; Yoshio Ozaki; Shosaku Nomura; T Miyake; Y Miyazaki; Hideo Kagawa; Y Yamanaka; Naoki Asazuma; Kaneo Satoh; S Kume; Y Komiyama; Shirou Fukuhara
Tyrosine phosphorylation and p72syk activation by an anti-glycoprotein Ib monoclonal antibody.
Blood 1997;89(5):1590-8.
1997: Yutaka Yatomi; Yoshio Ozaki; Kaneo Satoh; S Kume; F Ruan; Y Igarashi
N,N-dimethylsphingosine phosphorylation in human platelets.
Biochemical and biophysical research communications 1997;231(3):848-51.
1996: R Qi; Yoshio Ozaki; K Kuroda; Naoki Asazuma; Yutaka Yatomi; Kaneo Satoh; S Nomura; S Kume
Differential activation of human platelets induced by Fc gamma receptor II cross-linking and by anti-CD9 monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5638-45.
1996: L Yang; Yutaka Yatomi; N Hisano; R Qi; Naoki Asazuma; Kaneo Satoh; Y Igarashi; Yoshio Ozaki; S Kume
Activation of protein-tyrosine kinase Syk in human platelets stimulated with lysophosphatidic acid or sphingosine 1-phosphate.
Biochemical and biophysical research communications 1996;229(2):440-4.
1996: Kaneo Satoh; Yoshio Ozaki; Naoki Asazuma; Yutaka Yatomi; Q Ruomei; K Kuroda; L Yang; S Kume
Differential mobilization of tyrosine kinases in human platelets stimulated with thrombin or thrombin receptor agonist peptide.
Biochemical and biophysical research communications 1996;225(3):1084-9.
1996: R Qi; Yoshio Ozaki; Kaneo Satoh; L B Yang; Naoki Asazuma; Yutaka Yatomi; S Kume
Intracellular levels of cyclic AMP and cyclic GMP differentially modify platelet aggregate size in human platelets activated with epinephrine or ADP.
Journal of cardiovascular pharmacology 1996;28(2):215-22.
1996: Naoki Asazuma; Yutaka Yatomi; Yoshio Ozaki; R Qi; K Kuroda; Kaneo Satoh; S Kume
Protein-tyrosine phosphorylation and p72syk activation in human platelets stimulated with collagen is dependent upon glycoprotein Ia/IIa and actin polymerization.
Thrombosis and haemostasis 1996;75(4):648-54.
1996: Kaneo Satoh; Yoshio Ozaki; R Qi; L Yang; Naoki Asazuma; Yutaka Yatomi; S Kume
Factors that affect the size of platelet aggregates in epinephrine-induced activation: a study using the particle counting method based upon light scattering.
Thrombosis research 1996;81(5):515-23.
1996: R Qi; Yoshio Ozaki; Kaneo Satoh; K Kurota; Naoki Asazuma; Yutaka Yatomi; S Kume
Quantitative measurement of various 5-HT receptor antagonists on platelet activation induced by serotonin.
Thrombosis research 1996;81(1):43-54.
1995: K Kuroda; Yoshio Ozaki; R Qi; Naoki Asazuma; Yutaka Yatomi; Kaneo Satoh; S Nomura; M Suzuki; S Kume
Fc gamma II receptor-mediated platelet activation induced by anti-CD9 monoclonal antibody opens Ca2+ channels which are distinct from those associated with Ca2+ store depletion.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(9):4427-36.
1995: Yutaka Yatomi; Yoshio Ozaki; S Kume
Phosphoinositide metabolism triggered by wheat germ agglutinin in human platelets.
International journal of hematology 1995;62(3):163-73.
1995: S Hosogaya; S Kume
[Enzyme amplification in enzyme immunoassay].
Nihon rinsho. Japanese journal of clinical medicine 1995;53(9):2203-7.
1995: R Qi; Yoshio Ozaki; Kaneo Satoh; K Kurota; Naoki Asazuma; Yutaka Yatomi; S Kume
Sulphonylurea agents inhibit platelet aggregation and [Ca2+]i elevation induced by arachidonic acid.
Biochemical pharmacology 1995;49(12):1735-9.
1995: Kaneo Satoh; Yoshio Ozaki; S Kume
[Detection of platelet aggregates using light scattering].
Rinsho byori. The Japanese journal of clinical pathology 1995;43(5):426-31.
1995: Yoshio Ozaki; Kaneo Satoh; Yutaka Yatomi; S Miura; Y Fujimura; S Kume
Protein tyrosine phosphorylation in human platelets induced by interaction between glycoprotein Ib and von Willebrand factor.
Biochimica et biophysica acta 1995;1243(3):482-8.
1994: Kaneo Satoh; Yoshio Ozaki; Yutaka Yatomi; S Kume
Effects of sulfonylurea agents on platelet arachidonic acid metabolism; study on platelet homogenates.
Biochemical pharmacology 1994;48(5):1053-5.
1994: Yutaka Yatomi; Yoshio Ozaki; Kaneo Satoh; S Kume
Synthesis of phosphatidylinositol 3,4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85 alpha subunit of phosphatidylinositol 3-kinase may not be a target for tyrosine kinases in thrombin-stimulated human platelets.
Biochimica et biophysica acta 1994;1212(3):337-44.
1994: Y Koike; Yoshio Ozaki; R Qi; Kaneo Satoh; K Kurota; Yutaka Yatomi; S Kume
Phosphatase inhibitors suppress Ca2+ influx induced by receptor-mediated intracellular Ca2+ store depletion in human platelets.
Cell calcium 1994;15(5):381-90.
1994: Yutaka Yatomi; M Higashihara; K Kurokawa; Yoshio Ozaki; S Kume
Effects of the prior activation of protein kinase C on human platelet activation induced by thrombin.
International journal of hematology 1994;59(3):201-9.
1993: Yoshio Ozaki; Yutaka Yatomi; Y Jinnai; S Kume
Effects of genistein, a tyrosine kinase inhibitor, on platelet functions. Genistein attenuates thrombin-induced Ca2+ mobilization in human platelets by affecting polyphosphoinositide turnover.
Biochemical pharmacology 1993;46(3):395-403.
1993: Yutaka Yatomi; Yoshio Ozaki; Kaneo Satoh; S Kume
Anti-CD9 monoclonal antibody elicits staurosporine inhibitable phosphatidylinositol 4,5-bisphosphate hydrolysis, phosphatidylinositol 3,4-bisphosphate synthesis, and protein-tyrosine phosphorylation in human platelets.
FEBS letters 1993;322(3):285-90.
1993: Yoshio Ozaki; Y Jinnai; Yutaka Yatomi; M Tawata; T Onaya; S Kume
Effects of dilazep on platelet functions and volume change in patients with diabetes mellitus.
Arzneimittel-Forschung 1993;43(5):536-9.
1993: Yoshio Ozaki; Y Jinnai; Yutaka Yatomi; S Kume
Protein kinase C inhibitors suppress disc-sphere changes of human platelets, as assessed with the shape-change parameter.
European journal of pharmacology 1993;235(2-3):255-65.
1993: Yoshio Ozaki; Kaneo Satoh; Yutaka Yatomi; S Kume
Low concentrations of sodium fluoride inhibit Ca2+ influx induced by receptor-mediated platelet activation.
Biochimica et biophysica acta 1993;1147(1):27-34.
1993: Yutaka Yatomi; Yoshio Ozaki; Y Koike; Kaneo Satoh; S Kume
Wheat germ agglutinin-induced intracellular calcium mobilization in human platelets: suppression by staurosporine and resistance to cyclic AMP inhibition.
Biochemical and biophysical research communications 1993;191(2):453-8.
1992: Yoshio Ozaki; Yutaka Yatomi; S Kume
Effects of oral hypoglycaemic agents on platelet functions.
Biochemical pharmacology 1992;44(4):687-91.
1992: Yutaka Yatomi; Yoshio Ozaki; S Kume
Synthesis of phosphatidylinositol 3,4-bisphosphate but not phosphatidylinositol 3,4,5-trisphosphate is closely correlated with protein-tyrosine phosphorylation in thrombin-activated human platelets.
Biochemical and biophysical research communications 1992;186(3):1480-6.
1992: Yoshio Ozaki; Yutaka Yatomi; S Wakasugi; Y Shirasawa; H Saito; S Kume
Thrombin-induced calcium oscillation in human platelets and MEG-01, a megakaryoblastic leukemia cell line.
Biochemical and biophysical research communications 1992;183(2):864-71.
1992: Yoshio Ozaki; Y Yatomi; S Kume
[Evaluation of platelet intracellular calcium ion concentrations with flow cytometry].
Rinsho byori. The Japanese journal of clinical pathology 1992;40(3):282-6.
1992: Yoshio Ozaki; Yutaka Yatomi; S Kume
Evaluation of platelet calcium ion mobilization by the use of various divalent ions.
Cell calcium 1992;13(1):19-27.
1991: Yoshio Ozaki; Y Jinnai; Yutaka Yatomi; S Kume
Role of sodium ion gradient in facilitating extracellular calcium influx.
Thrombosis research 1991;64(2):179-90.
1991: Yoshio Ozaki; Y Matsumoto; Yutaka Yatomi; M Higashihara; S Kume
Two-step mobilization of arachidonic acid in platelet activation induced by low concentrations of TP 82, a monoclonal antibody against CD9 antigen.
European journal of biochemistry / FEBS 1991;199(2):347-54.
1991: S Kume
[Biochemical determinations of serum].
Nihon rinsho. Japanese journal of clinical medicine 1991;49(3):538-43.
1990: Yoshio Ozaki; Y Matsumoto; Yutaka Yatomi; M Higashihara; T Kariya; S Kume
Effects of various inhibitors on platelet activation induced by TP 82, a CD 9 monoclonal antibody.
Biochemical pharmacology 1990;40(7):1583-8.
1990: Y Matsumoto; Yoshio Ozaki; T Kariya; S Kume
Potentiating effects of endothelin on platelet activation induced by epinephrine and ADP.
Biochemical pharmacology 1990;40(4):909-11.
1990: Yoshio Ozaki; Y Matsumoto; Yutaka Yatomi; M Higashihara; S Kume
Modification of Na+/H+ exchanger in human platelets by 1,2-dioctanoylglycerol, a protein kinase C activator.
Thrombosis and haemostasis 1990;64(1):165-71.
1990: Yoshio Ozaki; Y Matsumoto; Yutaka Yatomi; M Higashihara; T Kariya; S Kume
Mastoparan, a wasp venom, activates platelets via pertussis toxin-sensitive GTP-binding proteins.
Biochemical and biophysical research communications 1990;170(2):779-85.
1990: Yoshio Ozaki; Y Matsumoto; Yutaka Yatomi; M Higashihara; T Kariya; S Kume
Ionomycin, a Ca++ ionophore, increases platelet volume independently of the Na+/H+ exchanger.
Thrombosis research 1990;57(1):87-95.