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Jeffrey Balser

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Franck Potet; Veniamin Y Sidorov; Svetlana Z Stepanovic; Raghav Venkataraman; C David Weaver; Beiyan Zou; L Michelle Lewis; Min Li; Craig W Lindsley; Amanda N Lorinc; David Afshartous; Jeffrey R Balser; Franz J Baudenbacher; Courtney M Campbell; Sebastien Chaigne; Emily Days; Darren W Engers; Alfred L George; Corey R Hopkins; Sabina Kupershmidt
Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias.
Bonnie M Miller; Donald E Moore; William W Stead; Jeffrey R Balser
Beyond Flexner: a new model for continuous learning in the health professions.
Tadashi Nakajima; Sean S Davies; E Matafonova; Franck Potet; Venkataraman Amarnath; K A Tallman; R A Serwa; N A Porter; Jeffrey R Balser; Sabina Kupershmidt; L Jackson Roberts
Selective gamma-ketoaldehyde scavengers protect Nav1.5 from oxidant-induced inactivation.

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All Publications

2012: Franck Potet; Veniamin Y Sidorov; Svetlana Z Stepanovic; Raghav Venkataraman; C David Weaver; Beiyan Zou; L Michelle Lewis; Min Li; Craig W Lindsley; Amanda N Lorinc; David Afshartous; Jeffrey R Balser; Franz J Baudenbacher; Courtney M Campbell; Sebastien Chaigne; Emily Days; Darren W Engers; Alfred L George; Corey R Hopkins; Sabina Kupershmidt
Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias.
The Journal of biological chemistry 2012;287(47):39613-25.
2010: Bonnie M Miller; Donald E Moore; William W Stead; Jeffrey R Balser
Beyond Flexner: a new model for continuous learning in the health professions.
Academic medicine : journal of the Association of American Medical Colleges 2010;85(2):266-72.
2010: Tadashi Nakajima; Sean S Davies; E Matafonova; Franck Potet; Venkataraman Amarnath; K A Tallman; R A Serwa; N A Porter; Jeffrey R Balser; Sabina Kupershmidt; L Jackson Roberts
Selective gamma-ketoaldehyde scavengers protect Nav1.5 from oxidant-induced inactivation.
Journal of molecular and cellular cardiology 2010;48(2):352-9.
2009: Toshio Yamagishi; Wei Xiong; Andrei Kondratiev; P Vélez; Ailsa Méndez-Fitzwilliam; Jeffrey R Balser; Eduardo Marban; Gordon F Tomaselli
Novel molecular determinants in the pore region of sodium channels regulate local anesthetic binding.
Molecular pharmacology 2009;76(4):861-71.
2009: Svetlana Z Stepanovic; Franck Potet; Christina I Petersen; Jarrod A Smith; Jens Meiler; Jeffrey R Balser; Sabina Kupershmidt
The evolutionarily conserved residue A653 plays a key role in HERG channel closing.
The Journal of physiology 2009;587(Pt 11):2555-66.
2009: Franck Potet; Benjamin Chagot; Mircea Anghelescu; Prakash C Viswanathan; Svetlana Z Stepanovic; Sabina Kupershmidt; Walter J Chazin; Jeffrey R Balser
Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of Calmodulin.
The Journal of biological chemistry 2009;284(13):8846-54.
2009: Benjamin Chagot; Franck Potet; Jeffrey R Balser; Walter J Chazin
Solution NMR structure of the C-terminal EF-hand domain of human cardiac sodium channel NaV1.5.
The Journal of biological chemistry 2009;284(10):6436-45.
2009: Franck Potet; Christina I Petersen; Olivier Boutaud; Wen Shuai; Svetlana Z Stepanovic; Jeffrey R Balser; Sabina Kupershmidt
Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator.
Journal of molecular and cellular cardiology 2009;46(2):257-67.
2008: Jeffrey R Balser; Andrea Baruchin
Science at the interstices: an evolution in the academy.
Academic medicine : journal of the Association of American Medical Colleges 2008;83(9):827-31.
2007: Penelope A Boyden; Sean S Davies; Prakash C Viswanathan; Venkataraman Amarnath; Jeffrey R Balser; L Jackson Roberts
Potential role of isoketals formed via the isoprostane pathway of lipid peroxidation in ischemic arrhythmias.
Journal of cardiovascular pharmacology 2007;50(5):480-6.
2007: Tadashi Nakajima; Kenshi Hayashi; Prakash C Viswanathan; Min-Young Kim; Mircea Anghelescu; Kate A Barksdale; Wen Shuai; Jeffrey R Balser; Sabina Kupershmidt
HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function.
The Journal of biological chemistry 2007;282(8):5506-13.
2006: Vikas N Shah; Tammy L Wingo; Kevin Weiss; Christina K Williams; Jeffrey R Balser; Walter J Chazin
Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3592-7.
2006: P C Viswanathan; Jeffrey R Balser
Molecular basis of isolated cardiac conduction disease.
Handbook of experimental pharmacology 2006;(171):331-47.
2006: Debra A Schwinn; Jeffrey R Balser
Anesthesiology physician scientists in academic medicine: a wake-up call.
Anesthesiology 2006;104(1):170-8.
2005: Koji Fukuda; Sean S Davies; Tadashi Nakajima; Boon-Hooi Ong; Sabina Kupershmidt; Joshua P Fessel; Venkataraman Amarnath; Mark E Anderson; Penelope A Boyden; Prakash C Viswanathan; L Jackson Roberts; Jeffrey R Balser
Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels.
Circulation research 2005;97(12):1262-9.
2005: Jeroen P P Smits; Tamara T Koopmann; Ronald Wilders; Marieke W Veldkamp; Tobias Opthof; Zahurul A Bhuiyan; marcel mannens; Jeffrey R Balser; Hanno L Tan; Connie R Bezzina; Arthur A M Wilde
A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families.
Journal of molecular and cellular cardiology 2005;38(6):969-81.
2005: Koji Fukuda; Tadashi Nakajima; Prakash C Viswanathan; Jeffrey R Balser
Compound-specific Na+ channel pore conformational changes induced by local anaesthetics.
The Journal of physiology 2005;564(Pt 1):21-31.
2004: Christina I Petersen; Toni R McFarland; Svetlana Z Stepanovic; Ping Yang; David Reiner; Kenshi Hayashi; Alfred L George; Dan Mark Roden; James H Thomas; Jeffrey R Balser
In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11773-8.
2004: Franklin M Mullins; Svetlana Z Stepanovic; Niloufar B Gillani; Alfred L George; Jeffrey R Balser
Functional interaction between extracellular sodium, potassium and inactivation gating in HERG channels.
The Journal of physiology 2004;558(Pt 3):729-44.
2004: A Thompson; Jeffrey R Balser
Perioperative cardiac arrhythmias.
British journal of anaesthesia 2004;93(1):86-94.
2004: Tammy L Wingo; Vikas N Shah; Mark E Anderson; Terry P Lybrand; Walter J Chazin; Jeffrey R Balser
An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.
Nature structural & molecular biology 2004;11(3):219-25.
2004: Prakash C Viswanathan; Jeffrey R Balser
Inherited sodium channelopathies: a continuum of channel dysfunction.
Trends in cardiovascular medicine 2004;14(1):28-35.
2003: Sabina Kupershmidt; Iris C-H Yang; Kenshi Hayashi; Jian Wei; Siprachanh Chanthaphaychith; Christina I Petersen; David C Johns; Alfred L George; Dan Mark Roden; Jeffrey R Balser
The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(15):2263-5.
2003: Laura A Hastings; Jeffrey R Balser
New treatments for perioperative cardiac arrhythmias.
Anesthesiology clinics of North America 2003;21(3):569-86.
2003: Brian S Donahue; Jeffrey R Balser
Perioperative genomics. Venturing into uncharted seas.
Anesthesiology 2003;99(1):7-8.
2003: Prakash C Viswanathan; D Woodrow Benson; Jeffrey R Balser
A common SCN5A polymorphism modulates the biophysical effects of an SCN5A mutation.
The Journal of clinical investigation 2003;111(3):341-6.
2002: Igor Dzhura; Yuejin Wu; Roger J Colbran; Jackie D Corbin; Jeffrey R Balser; Mark E Anderson
Cytoskeletal disrupting agents prevent calmodulin kinase, IQ domain and voltage-dependent facilitation of L-type Ca2+ channels.
The Journal of physiology 2002;545(Pt 2):399-406.
2002: Franklin M Mullins; Svetlana Z Stepanovic; Reshma R Desai; Alfred L George; Jeffrey R Balser
Extracellular sodium interacts with the HERG channel at an outer pore site.
The Journal of general physiology 2002;120(4):517-37.
2002: Sabina Kupershmidt; Iris C-H Yang; Margaret Sutherland; K Sam Wells; Tao Yang; Ping Yang; Jeffrey R Balser; Dan Mark Roden
Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system.
Cardiovascular research 2002;56(1):93-103.
2002: Jeffrey R Balser
Inherited sodium channelopathies: models for acquired arrhythmias?
American journal of physiology. Heart and circulatory physiology 2002;282(4):H1175-80.
2002: Jeffrey R Balser
Perioperative arrhythmias: incidence, risk assessment, evaluation, and management.
Cardiac electrophysiology review 2002;6(1-2):96-9.
2002: Hanno L Tan; Sabina Kupershmidt; Rong Zhang; Svetlana Z Stepanovic; Dan Mark Roden; Arthur A M Wilde; Mark E Anderson; Jeffrey R Balser
A calcium sensor in the sodium channel modulates cardiac excitability.
Nature 2002;415(6870):442-7.
2002: Dao W Wang; Prakash C Viswanathan; Jeffrey R Balser; Alfred L George; D Woodrow Benson
Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block.
Circulation 2002;105(3):341-6.
2002: Dan Mark Roden; Jeffrey R Balser; Alfred L George; Mark E Anderson
Cardiac ion channels.
Annual review of physiology 2002;64():431-75.
2001: Prakash C Viswanathan; Connie R Bezzina; Alfred L George; Dan Mark Roden; Arthur A M Wilde; Jeffrey R Balser
Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes.
Circulation 2001;104(10):1200-5.
2001: Jeffrey R Balser
Inherited sodium channelopathies: novel therapeutic and proarrhythmic molecular mechanisms.
Trends in cardiovascular medicine 2001;11(6):229-37.
2001: JP Johnson; Jeffrey R Balser; Paul Bennett
A novel extracellular calcium sensing mechanism in voltage-gated potassium ion channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(12):4143-53.
2001: Jeffrey R Balser
The cardiac sodium channel: gating function and molecular pharmacology.
Journal of molecular and cellular cardiology 2001;33(4):599-613.
2001: Hanno L Tan; Margreet Th E Bink-Boelkens; Connie R Bezzina; Prakash C Viswanathan; Gertie C M Beaufort-Krol; P J van Tintelen; Maarten P van den Berg; Arthur A M Wilde; Jeffrey R Balser
A sodium-channel mutation causes isolated cardiac conduction disease.
Nature 2001;409(6823):1043-7.
2000: H Numaguchi; Franklin M Mullins; JP Johnson; David C Johns; SS Po; Iris C-H Yang; Gordon F Tomaselli; Jeffrey R Balser
Probing the interaction between inactivation gating and Dd-sotalol block of HERG.
Circulation research 2000;87(11):1012-8.
2000: Boon-Hooi Ong; Gordon F Tomaselli; Jeffrey R Balser
A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence.
The Journal of general physiology 2000;116(5):653-62.
2000: Dao W Wang; N Makita; A Kitabatake; Jeffrey R Balser; Alfred L George
Enhanced Na(+) channel intermediate inactivation in Brugada syndrome.
Circulation research 2000;87(8):E37-43.
2000: Marieke W Veldkamp; Prakash C Viswanathan; Connie R Bezzina; Antonius Baartscheer; Arthur A M Wilde; Jeffrey R Balser
Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel.
Circulation research 2000;86(9):E91-7.
2000: H Numaguchi; JP Johnson; Christina I Petersen; Jeffrey R Balser
A sensitive mechanism for cation modulation of potassium current.
Nature neuroscience 2000;3(5):429-30.
2000: NG Kambouris; H Bradley Nuss; David C Johns; Eduardo Marban; Gordon F Tomaselli; Jeffrey R Balser
A revised view of cardiac sodium channel "blockade" in the long-QT syndrome.
The Journal of clinical investigation 2000;105(8):1133-40.
2000: Z Chen; Boon-Hooi Ong; NG Kambouris; Eduardo Marban; Gordon F Tomaselli; Jeffrey R Balser
Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels.
The Journal of physiology 2000;524 Pt 1():37-49.
2000: Igor Dzhura; Yuejin Wu; Roger J Colbran; Jeffrey R Balser; Mark E Anderson
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels.
Nature cell biology 2000;2(3):173-7.
2000: H Bradley Nuss; NG Kambouris; Eduardo Marban; Gordon F Tomaselli; Jeffrey R Balser
Isoform-specific lidocaine block of sodium channels explained by differences in gating.
Biophysical journal 2000;78(1):200-10.
1999: J P Johnson; Jeffrey R Balser; Paul Bennett
Enhancement of HERG K+ currents by Cd2+ destabilization of the inactivated state.
Biophysical journal 1999;77(5):2534-41.
1999: Jeffrey R Balser
Structure and function of the cardiac sodium channels.
Cardiovascular research 1999;42(2):327-38.
1999: Jean-Pierre Benitah; Z Chen; Jeffrey R Balser; Gordon F Tomaselli; Eduardo Marban
Molecular dynamics of the sodium channel pore vary with gating: interactions between P-segment motions and inactivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(5):1577-85.
1999: Jeffrey R Balser
Pro: All patients should receive pharmacologic prophylaxis for atrial fibrillation after cardiac surgery.
Journal of cardiothoracic and vascular anesthesia 1999;13(1):98-100.
1998: Jeffrey R Balser; Elizabeth A Martinez; Bradford D Winters; P W Perdue; A W Clarke; W Huang; Gordon F Tomaselli; Todd Dorman; K Campbell; Pamela A Lipsett; Michael J Breslow; Brian A Rosenfeld
Beta-adrenergic blockade accelerates conversion of postoperative supraventricular tachyarrhythmias.
Anesthesiology 1998;89(5):1052-9.
1998: NG Kambouris; L A Hastings; Svetlana Z Stepanovic; Eduardo Marban; Gordon F Tomaselli; Jeffrey R Balser
Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat micro1 skeletal muscle sodium channel.
The Journal of physiology 1998;512 ( Pt 3)():693-705.
1998: Todd Dorman; Michael J Breslow; Pamela A Lipsett; J M Rosenberg; Jeffrey R Balser; Y Almog; Brian A Rosenfeld
Radial artery pressure monitoring underestimates central arterial pressure during vasopressor therapy in critically ill surgical patients.
Critical care medicine 1998;26(10):1646-9.
1998: J Pu; Jeffrey R Balser; Penelope A Boyden
Lidocaine action on Na+ currents in ventricular myocytes from the epicardial border zone of the infarcted heart.
Circulation research 1998;83(4):431-40.
1998: P W Perdue; Jeffrey R Balser; Pamela A Lipsett; Michael J Breslow
"Renal dose" dopamine in surgical patients: dogma or science?
Annals of surgery 1998;227(4):470-3.
1998: NG Kambouris; H Bradley Nuss; David C Johns; Gordon F Tomaselli; Eduardo Marban; Jeffrey R Balser
Phenotypic characterization of a novel long-QT syndrome mutation (R1623Q) in the cardiac sodium channel.
Circulation 1998;97(7):640-4.
1998: Jeffrey R Balser
The molecular interaction between local anesthetic/antiarrhythmic agents and voltage-gated sodium channels.
Trends in cardiovascular medicine 1998;8(2):83-8.
1997: Jeffrey R Balser
The rational use of intravenous amiodarone in the perioperative period.
Anesthesiology 1997;86(4):974-87.
1997: M T Pérez-García; Nipavan Chiamvimonvat; R Ranjan; Jeffrey R Balser; Gordon F Tomaselli; Eduardo Marban
Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modification.
Biophysical journal 1997;72(3):989-96.
1997: Jean-Pierre Benitah; Jeffrey R Balser; Eduardo Marban; Gordon F Tomaselli
Proton inhibition of sodium channels: mechanism of gating shifts and reduced conductance.
The Journal of membrane biology 1997;155(2):121-31.
1996: Jeffrey R Balser; H Bradley Nuss; D W Orias; David C Johns; Eduardo Marban; Gordon F Tomaselli; JH Lawrence
Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels.
The Journal of clinical investigation 1996;98(12):2874-86.
1996: JH Lawrence; D W Orias; Jeffrey R Balser; H Bradley Nuss; Gordon F Tomaselli; Brian O'Rourke; Eduardo Marban
Single-channel analysis of inactivation-defective rat skeletal muscle sodium channels containing the F1304Q mutation.
Biophysical journal 1996;71(3):1285-94.
1996: Jeffrey R Balser; H Bradley Nuss; Nipavan Chiamvimonvat; M T Pérez-García; Eduardo Marban; Gordon F Tomaselli
External pore residue mediates slow inactivation in mu 1 rat skeletal muscle sodium channels.
The Journal of physiology 1996;494 ( Pt 2)():431-42.
1996: H Bradley Nuss; Jeffrey R Balser; D W Orias; JH Lawrence; Gordon F Tomaselli; Eduardo Marban
Coupling between fast and slow inactivation revealed by analysis of a point mutation (F1304Q) in mu 1 rat skeletal muscle sodium channels.
The Journal of physiology 1996;494 ( Pt 2)():411-29.
1996: Jeffrey R Balser; H Bradley Nuss; D N Romashko; Eduardo Marban; Gordon F Tomaselli
Functional consequences of lidocaine binding to slow-inactivated sodium channels.
The Journal of general physiology 1996;107(5):643-58.
1995: Gordon F Tomaselli; Nipavan Chiamvimonvat; H Bradley Nuss; Jeffrey R Balser; M T Pérez-García; R H Xu; D W Orias; P H Backx; Eduardo Marban
A mutation in the pore of the sodium channel alters gating.
Biophysical journal 1995;68(5):1814-27.