FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Muthusamy Kunnimalaiyaan

Research Profile

Physiology

Chemicals & Drugs

Anatomy

Disorders

Phenomena

Blotting, Western

Co-author Network

Publications

TOP 3
Yash Somnay; Herbert Chen; April D Harrison; Selvi Kunnimalaiyaan; Kevin Simon; Muthusamy Kunnimalaiyaan
Neuroendocrine phenotype alteration and growth suppression through apoptosis by MK-2206, an allosteric inhibitor of AKT, in carcinoid cell lines in vitro.
Yash Somnay; Herbert Chen; Muthusamy Kunnimalaiyaan
Synergistic effect of pasireotide and teriflunomide in carcinoids in vitro.
Yuling Xiao; Wenjin Xu; Renata Jaskula-Sztul; Alireza Javadi; Muthusamy Kunnimalaiyaan; Herbert Chen; Ajitha Dammalapati; Jacob Eide; Shaoqin Gong
Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Muthusamy Kunnimalaiyaan (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Yash Somnay; Herbert Chen; April D Harrison; Selvi Kunnimalaiyaan; Kevin Simon; Muthusamy Kunnimalaiyaan
Neuroendocrine phenotype alteration and growth suppression through apoptosis by MK-2206, an allosteric inhibitor of AKT, in carcinoid cell lines in vitro.
Anti-cancer drugs 2013;24(1):66-72.
2013: Yash Somnay; Herbert Chen; Muthusamy Kunnimalaiyaan
Synergistic effect of pasireotide and teriflunomide in carcinoids in vitro.
Neuroendocrinology 2013;97(2):183-92.
2012: Yuling Xiao; Wenjin Xu; Renata Jaskula-Sztul; Alireza Javadi; Muthusamy Kunnimalaiyaan; Herbert Chen; Ajitha Dammalapati; Jacob Eide; Shaoqin Gong
Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy.
Nanoscale 2012;4(22):7185-93.
2011: Renata Jaskula-Sztul; Michael Landowski; Pongthep Pisarnturakit; Herbert Chen; Muthusamy Kunnimalaiyaan
Expression of the active Notch1 decreases MTC tumor growth in vivo.
The Journal of surgical research 2011;171(1):23-7.
2011: TramAnh Phan; Xiao-Min Yu; Muthusamy Kunnimalaiyaan; Herbert Chen
Antiproliferative effect of chrysin on anaplastic thyroid cancer.
The Journal of surgical research 2011;170(1):84-8.
2011: Matthew Truong; Mackenzie R Cook; Scott N Pinchot; Muthusamy Kunnimalaiyaan; Herbert Chen
Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer.
Annals of surgical oncology 2011;18(5):1506-11.
2011: Scott N Pinchot; Renata Jaskula-Sztul; Li Ning; noel peters; Mackenzie R Cook; Muthusamy Kunnimalaiyaan; Herbert Chen
Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method.
Cancer 2011;117(7):1386-98.
2011: Barbara Zarebczan; Scott N Pinchot; Muthusamy Kunnimalaiyaan; Herbert Chen
Hesperetin, a potential therapy for carcinoid cancer.
American journal of surgery 2011;201(3):329-32; discussion 333.
2011: Sam J Lubner; Muthusamy Kunnimalaiyaan; Kyle D Holen; Li Ning; Mary Ndiaye; Noelle K Loconte; Daniel Mulkerin; William R Schelman; Herbert Chen
A preclinical and clinical study of lithium in low-grade neuroendocrine tumors.
The oncologist 2011;16(4):452-7.
2010: Goswin Y Meyer-Rochow; Nicole E Jackson; John V Conaglen; Denis E Whittle; Muthusamy Kunnimalaiyaan; Herbert Chen; Gunnar Westin; Johanna Sandgren; Peter Stålberg; Elham Khanafshar; Daniel Shibru; Quan-Yang Duh; Orlo H Clark; Electron Kebebew; Anthony J Gill; Roderick J Clifton-Bligh; Bruce G Robinson; Diana E Benn; Stan B Sidhu
MicroRNA profiling of benign and malignant pheochromocytomas identifies novel diagnostic and therapeutic targets.
Endocrine-related cancer 2010;17(3):835-46.
2010: Dustin Deming; Peter Geiger; Herbert Chen; Muthusamy Kunnimalaiyaan; Kyle Holen
ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines.
The Journal of surgical research 2010;161(1):28-32.
2010: Li Ning; Herbert Chen; Muthusamy Kunnimalaiyaan
Focal adhesion kinase, a downstream mediator of Raf-1 signaling, suppresses cellular adhesion, migration, and neuroendocrine markers in BON carcinoid cells.
Molecular cancer research : MCR 2010;8(5):775-82.
2010: Stephen L Rose; Muthusamy Kunnimalaiyaan; Jessica Drenzek; Nicole Seiler
Notch 1 signaling is active in ovarian cancer.
Gynecologic oncology 2010;117(1):130-3.
2010: Joel Adler; Daniel G Hottinger; Muthusamy Kunnimalaiyaan; Herbert Chen
Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride.
The Journal of surgical research 2010;159(2):640-4.
2010: Mackenzie R Cook; Jie Luo; Mary Ndiaye; Herbert Chen; Muthusamy Kunnimalaiyaan
Xanthohumol inhibits the neuroendocrine transcription factor achaete-scute complex-like 1, suppresses proliferation, and induces phosphorylated ERK1/2 in medullary thyroid cancer.
American journal of surgery 2010;199(3):315-8; discussion 318.
2010: Mackenzie R Cook; Scott N Pinchot; Renata Jaskula-Sztul; Jie Luo; Muthusamy Kunnimalaiyaan; Herbert Chen
Identification of a novel Raf-1 pathway activator that inhibits gastrointestinal carcinoid cell growth.
Molecular cancer therapeutics 2010;9(2):429-37.
2010: Vinita M Alexander; Madhuchhanda Roy; Kristen A Steffens; Muthusamy Kunnimalaiyaan; Herbert Chen
Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids.
International journal of clinical and experimental medicine 2010;3(2):95-102.
2010: David Yu Greenblatt; Mary Ndiaye; Herbert Chen; Muthusamy Kunnimalaiyaan
Lithium inhibits carcinoid cell growth in vitro.
American journal of translational research 2010;2(3):248-53.
2010: Jui-yu Chen; Mackenzie R Cook; Scott N Pinchot; Muthusamy Kunnimalaiyaan; Herbert Chen
MG-132 inhibits carcinoid growth and alters the neuroendocrine phenotype.
The Journal of surgical research 2010;158(1):15-9.
2009: Joel Adler; Daniel G Hottinger; Muthusamy Kunnimalaiyaan; Herbert Chen
Inhibition of the PI3K pathway suppresses hormonal secretion and limits growth in pheochromocytoma cells.
World journal of surgery 2009;33(11):2452-7.
2009: Susan C Pitt; Herbert Chen; Muthusamy Kunnimalaiyaan
Inhibition of phosphatidylinositol 3-kinase/Akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors.
Annals of surgical oncology 2009;16(10):2936-42.
2009: Susan C Pitt; Herbert Chen; Muthusamy Kunnimalaiyaan
Phosphatidylinositol 3-kinase-Akt signaling in pulmonary carcinoid cells.
Journal of the American College of Surgeons 2009;209(1):82-8.
2009: Joel Adler; Mackenzie Cook; Yinggang Luo; Susan C Pitt; Jianhua Ju; Wenli Li; Ben Shen; Muthusamy Kunnimalaiyaan; Herbert Chen
Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta.
Molecular cancer therapeutics 2009;8(4):914-20.
2009: Scott N Pinchot; Joel Adler; Yinggang Luo; Jianhua Ju; Wenli Li; Ben Shen; Muthusamy Kunnimalaiyaan; Herbert Chen
Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway.
American journal of surgery 2009;197(3):313-9.
2009: Joel Adler; Daniel G Hottinger; Muthusamy Kunnimalaiyaan; Herbert Chen
Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors.
Annals of surgical oncology 2009;16(2):481-6.
2009: Scott N Pinchot; Muthusamy Kunnimalaiyaan; Rebecca S Sippel; Herbert Chen
Medullary thyroid carcinoma: targeted therapies and future directions.
Journal of oncology 2009;2009():183031.
2009: Susan C Pitt; Ruth Davis; Muthusamy Kunnimalaiyaan; Herbert Chen
AKT and PTEN expression in human gastrointestinal carcinoid tumors.
American journal of translational research 2009;1(3):291-9.
2009: Cara Ar Goodell; Jennifer A Belisle; Jennifer Aa Gubbels; Martine Migneault; Claudine Rancourt; Joseph Connor; Muthusamy Kunnimalaiyaan; Rachel Kravitz; Ward Tucker; Michael Zwick; Manish S Patankar
Characterization of the tumor marker muc16 (ca125) expressed by murine ovarian tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies.
Journal of ovarian research 2009;2(1):8.
2008: Joel Adler; Daniel G Hottinger; Muthusamy Kunnimalaiyaan; Herbert Chen
Histone deacetylase inhibitors upregulate Notch-1 and inhibit growth in pheochromocytoma cells.
Surgery 2008;144(6):956-61; discussion 961-2.
2008: Li Ning; Muthusamy Kunnimalaiyaan; Herbert Chen
Regulation of cell-cell contact molecules and the metastatic phenotype of medullary thyroid carcinoma by the Raf-1/MEK/ERK pathway.
Surgery 2008;144(6):920-4; discussion 924-5.
2008: Li Ning; Renata Jaskula-Sztul; Muthusamy Kunnimalaiyaan; Herbert Chen
Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma.
Annals of surgical oncology 2008;15(9):2600-5.
2008: Christopher S Platta; David Yü Greenblatt; Muthusamy Kunnimalaiyaan; Herbert Chen
Valproic acid induces Notch1 signaling in small cell lung cancer cells.
The Journal of surgical research 2008;148(1):31-7.
2008: David Yu Greenblatt; Max A Cayo; Joel Adler; Li Ning; Megan Haymart; Muthusamy Kunnimalaiyaan; Herbert Chen
Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells.
Annals of surgery 2008;247(6):1036-40.
2008: Scott N Pinchot; Susan C Pitt; Rebecca S Sippel; Muthusamy Kunnimalaiyaan; Herbert Chen
Novel targets for the treatment and palliation of gastrointestinal neuroendocrine tumors.
Current opinion in investigational drugs (London, England : 2000) 2008;9(6):576-82.
2008: Rebecca S Sippel; Muthusamy Kunnimalaiyaan; Herbert Chen
Current management of medullary thyroid cancer.
The oncologist 2008;13(5):539-47.
2008: Dustin Deming; Peter Geiger; Herbert Chen; Abram Vaccaro; Muthusamy Kunnimalaiyaan; Kyle Holen
ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2008;12(5):852-7.
2008: Li Ning; David Yu Greenblatt; Muthusamy Kunnimalaiyaan; Herbert Chen
Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells.
The oncologist 2008;13(2):98-104.
2007: Muthusamy Kunnimalaiyaan; Mary Ndiaye; Herbert Chen
Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways.
Surgery 2007;142(6):959-64; discussion 959-64.
2007: David Yu Greenblatt; Max Cayo; Li Ning; Renata Jaskula-Sztul; Megan Haymart; Muthusamy Kunnimalaiyaan; Herbert Chen
Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2007;11(11):1515-20; discussion 1520.
2007: Christopher S Platta; David Yü Greenblatt; Muthusamy Kunnimalaiyaan; Herbert Chen
The HDAC inhibitor trichostatin A inhibits growth of small cell lung cancer cells.
The Journal of surgical research 2007;142(2):219-26.
2007: David Yu Greenblatt; Abram Vaccaro; Renata Jaskula-Sztul; Li Ning; Megan Haymart; Muthusamy Kunnimalaiyaan; Herbert Chen
Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells.
The oncologist 2007;12(8):942-51.
2007: Muthusamy Kunnimalaiyaan; Herbert Chen
Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors.
The oncologist 2007;12(5):535-42.
2007: Muthusamy Kunnimalaiyaan; Abram Vaccaro; Mary A Ndiaye; Herbert Chen
Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells.
Molecular cancer therapeutics 2007;6(3):1151-8.
2007: David Yü Greenblatt; Muthusamy Kunnimalaiyaan; Herbert Chen
Raf-1 activation in gastrointestinal carcinoid cells decreases tumor cell adhesion.
American journal of surgery 2007;193(3):331-5; discussion 335.
2007: Ashley Kappes; Abram Vaccaro; Muthusamy Kunnimalaiyaan; Herbert Chen
Lithium ions: a novel treatment for pheochromocytomas and paragangliomas.
Surgery 2007;141(2):161-5; discussion 165.
2007: Muthusamy Kunnimalaiyaan; Megan Haymart; Herbert Chen
Tumor suppressor role of notch1 and raf-1 signaling in medullary thyroid cancer cells.
Translational oncogenomics 2007;2():43-7.
2006: Muthusamy Kunnimalaiyaan; Abram Vaccaro; Mary A Ndiaye; Herbert Chen
Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells.
The Journal of biological chemistry 2006;281(52):39819-30.
2006: Muthusamy Kunnimalaiyaan; Mary Ndiaye; Herbert Chen
Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002.
Surgery 2006;140(6):1009-14; discussion 1014-5.
2006: Abram Vaccaro; Herbert Chen; Muthusamy Kunnimalaiyaan
In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer.
Anti-cancer drugs 2006;17(7):849-53.
2006: Ashley Kappes; Abram Vaccaro; Muthusamy Kunnimalaiyaan; Herbert Chen
ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells.
The Journal of surgical research 2006;133(1):42-5.
2006: Muthusamy Kunnimalaiyaan; Herbert Chen
The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors?
Anti-cancer drugs 2006;17(2):139-42.
2005: Muthusamy Kunnimalaiyaan; Sonia Yan; Francis Wong; Yi-Wei Zhang; Herbert Chen
Hairy Enhancer of Split-1 (HES-1), a Notch1 effector, inhibits the growth of carcinoid tumor cells.
Surgery 2005;138(6):1137-42; discussion 1142.
2005: Muthusamy Kunnimalaiyaan; Kelly Traeger; Herbert Chen
Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(4):G636-42.
2005: Eric K Nakakura; Virote Sriuranpong; Muthusamy Kunnimalaiyaan; Edward C Hsiao; Kornel E Schuebel; Michael W Borges; Ning Jin; Brendan J Collins; Barry D Nelkin; Herbert Chen; Douglas W Ball
Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling.
The Journal of clinical endocrinology and metabolism 2005;90(7):4350-6.
2005: Herbert Chen; Muthusamy Kunnimalaiyaan; Jamie J Van Gompel
Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1.
Thyroid : official journal of the American Thyroid Association 2005;15(6):511-21.
2005: Jamie J Van Gompel; Muthusamy Kunnimalaiyaan; Kyle Holen; Herbert Chen
ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells.
Molecular cancer therapeutics 2005;4(6):910-7.
2005: Muthusamy Kunnimalaiyaan; Patricia S Vary
Molecular characterization of plasmid pBM300 from Bacillus megaterium QM B1551.
Applied and environmental microbiology 2005;71(6):3068-76.
2005: Sandeepa Musunuru; Jennifer E Carpenter; Rebecca S Sippel; Muthusamy Kunnimalaiyaan; Herbert Chen
A mouse model of carcinoid syndrome and heart disease.
The Journal of surgical research 2005;126(1):102-5.
2003: Rebecca S Sippel; Jennifer E Carpenter; Muthusamy Kunnimalaiyaan; Herbert Chen
The role of human achaete-scute homolog-1 in medullary thyroid cancer cells.
Surgery 2003;134(6):866-71; discussion 871-3.
2003: Michael D Scholle; Christen A White; Muthusamy Kunnimalaiyaan; Patricia S Vary
Sequencing and characterization of pBM400 from Bacillus megaterium QM B1551.
Applied and environmental microbiology 2003;69(11):6888-98.
2003: Rebecca S Sippel; Jennifer E Carpenter; Muthusamy Kunnimalaiyaan; Sara Lagerholm; Herbert Chen
Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(2):G245-54.
2001: Muthusamy Kunnimalaiyaan; D M Stevenson; Y Zhou; Patricia S Vary
Analysis of the replicon region and identification of an rRNA operon on pBM400 of Bacillus megaterium QM B1551.
Molecular microbiology 2001;39(4):1010-21.
1998: D M Stevenson; Muthusamy Kunnimalaiyaan; K Müller; Patricia S Vary
Characterization of a theta plasmid replicon with homology to all four large plasmids of Bacillus megaterium QM B1551.
Plasmid 1998;40(3):175-89.