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Shigeru Kunugi

Research Profile

Concepts & Ideas

Phenomena

Disorders

Protein Denaturation

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Thermodynamics

Chemicals & Drugs

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Fluorescence Spectrometry

Physiology

Protein Folding

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TOP 3
Naoki Tanaka; Yumi Morimoto; Yurika Noguchi; Tomoko Tada; Tomonori Waku; Shigeru Kunugi; Takashi Morii; Yin-Fai Lee; Takashi Konno; Nobuyuki Takahashi
The mechanism of fibril formation of a non-inhibitory serpin ovalbumin revealed by the identification of amyloidogenic core regions.
Yasunori Fujimoto; Hidekazu Ikeuchi; Tomoko Tada; Hiroshi Oyama; Kohei Oda; Shigeru Kunugi
Synergetic effects of pressure and chemical denaturant on protein unfolding: stability of a serine-type carboxyl protease, kumamolisin.
Shigeru Kunugi; K Kameyama; T Tada; N Tanaka; M Shibayama; M Akashi
Differences in pressure and temperature transitions of proteins and polymer gels.

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2011: Naoki Tanaka; Yumi Morimoto; Yurika Noguchi; Tomoko Tada; Tomonori Waku; Shigeru Kunugi; Takashi Morii; Yin-Fai Lee; Takashi Konno; Nobuyuki Takahashi
The mechanism of fibril formation of a non-inhibitory serpin ovalbumin revealed by the identification of amyloidogenic core regions.
The Journal of biological chemistry 2011;286(7):5884-94.
2006: Yasunori Fujimoto; Hidekazu Ikeuchi; Tomoko Tada; Hiroshi Oyama; Kohei Oda; Shigeru Kunugi
Synergetic effects of pressure and chemical denaturant on protein unfolding: stability of a serine-type carboxyl protease, kumamolisin.
Biochimica et biophysica acta 2006;1764(3):364-71.
2005: Shigeru Kunugi; K Kameyama; T Tada; N Tanaka; M Shibayama; M Akashi
Differences in pressure and temperature transitions of proteins and polymer gels.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2005;38(8):1233-8.
2005: Naoki Tanaka; Shota Nakao; Jean Chatellier; Yasushi Tani; Tomoko Tada; Shigeru Kunugi
Effect of the polypeptide binding on the thermodynamic stability of the substrate binding domain of the DnaK chaperone.
Biochimica et biophysica acta 2005;1748(1):1-8.
2004: Naoki Tanaka; Yasushi Tani; Hiroyuki Hattori; Tomoko Tada; Shigeru Kunugi
Interaction of the N-terminal domain of Escherichia coli heat-shock protein ClpB and protein aggregates during chaperone activity.
Protein science : a publication of the Protein Society 2004;13(12):3214-21.
2004: T Tanaka; Hidekazu Ikeuchi; Nobuo Tanaka; Shigeru Kunugi
Pressure-temperature-induced denaturation of yeast phosphoglycerate kinase, a double-domain protein.
Cellular and molecular biology (Noisy-le-Grand, France) 2004;50(4):317-22.
2003: Tetsuji Yamaoka; Takumi Tamura; Yuuki Seto; Tomoko Tada; Shigeru Kunugi; David A Tirrell
Mechanism for the phase transition of a genetically engineered elastin model peptide (VPGIG)40 in aqueous solution.
Biomacromolecules 2003;4(6):1680-5.
2002: Naoki Tanaka; Shota Nakao; Hiromasa Wadai; Shoichi Ikeda; Jean Chatellier; Shigeru Kunugi
The substrate binding domain of DnaK facilitates slow protein refolding.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15398-403.
2002: Naoki Tanaka; Sachie Kajimoto; Daisuke Mitani; Shigeru Kunugi
Effects of guanidine hydrochloride and high pressure on subsite flexibility of beta-amylase.
Biochimica et biophysica acta 2002;1596(2):318-25.
2002: Shigeru Kunugi; Naoki Tanaka
Cold denaturation of proteins under high pressure.
Biochimica et biophysica acta 2002;1595(1-2):329-44.
2001: Naoki Tanaka; D Mitani; Shigeru Kunugi
Pressure-induced perturbation on the active site of beta-amylase monitored from the sulfhydryl reaction.
Biochemistry 2001;40(20):5914-20.
2001: S Fujiwara; Shigeru Kunugi; H Oyama; Kohei Oda
Effects of pressure on the activity and spectroscopic properties of carboxyl proteinases. Apparent correlation of pepstatin-insensitivity and pressure response.
European journal of biochemistry / FEBS 2001;268(3):645-55.
2000: Hidekazu Ikeuchi; Shigeru Kunugi; Kohei Oda
Activity and stability of a neutral protease from Vibrio sp. (vimelysin) in a pressure-temperature gradient.
European journal of biochemistry / FEBS 2000;267(4):979-83.
2000: T Tamura; Tetsuji Yamaoka; Shigeru Kunugi; Alyssa Panitch; David A Tirrell
Effects of temperature and pressure on the aggregation properties of an engineered elastin model polypeptide in aqueous solution.
Biomacromolecules 2000;1(4):552-5.
1999: Shigeru Kunugi; S Fujiwara; S Kidokoro; K Endo; S Hanzawa
Single-point amino acid substitutions at the 119th residue of thermolysin and their pressure-induced activation.
FEBS letters 1999;462(3):231-5.
1999: Shigeru Kunugi; Y Yanagi; Kohei Oda
Studies on the formation and stability of a complex between Streptomyces proteinaceous metalloprotease inhibitor and thermolysin.
European journal of biochemistry / FEBS 1999;259(3):815-20.
1998: Guo-Qing Tang; Naoki Tanaka; Shigeru Kunugi
In vitro increases in plasmid DNA supercoiling by hydrostatic pressure.
Biochimica et biophysica acta 1998;1443(3):364-8.
1997: Shigeru Kunugi; M Kitayaki; Y Yanagi; N Tanaka; R Lange; C Balny
The effect of high pressure on thermolysin.
European journal of biochemistry / FEBS 1997;248(2):567-74.
1997: Naoki Tanaka; T Tonai; Shigeru Kunugi
Site-specific modification of rabbit muscle creatine kinase with sulfhydryl-specific fluorescence probe by use of hydrostatic pressure.
Biochimica et biophysica acta 1997;1339(2):226-32.
1997: Naoki Tanaka; H Nishizawa; Shigeru Kunugi
Structure of pressure-induced denatured state of human serum albumin: a comparison with the intermediate in urea-induced denaturation.
Biochimica et biophysica acta 1997;1338(1):13-20.
1997: Shigeru Kunugi; A Koyasu; S Takahashi; Kohei Oda
Peptide condensation activity of a neutral protease from Vibrio sp. T1800 (Vimelysin).
Biotechnology and bioengineering 1997;53(4):387-90.
1996: Shigeru Kunugi; A Koyasu; M Kitayaki; S Takahashi; Kohei Oda
Kinetic characterization of the neutral protease vimelysin from Vibrio sp. T1800.
European journal of biochemistry / FEBS 1996;241(2):368-73.
1996: Naoki Tanaka; K Nakajima; Shigeru Kunugi
The pressure-induced structural change of bovine alpha-lactalbumin as studied by a fluorescence hydrophobic probe.
International journal of peptide and protein research 1996;48(3):259-64.
1996: Naoki Tanaka; Y Tsurui; I Kobayashi; Shigeru Kunugi
Modification of the single unpaired sulfhydryl group of beta-lactoglobulin under high pressure and the role of intermolecular S-S exchange in the pressure denaturation [single SH of beta-lactoglobulin and pressure denaturation].
International journal of biological macromolecules 1996;19(1):63-8.
1996: Naoki Tanaka; A Koyasu; I Kobayashi; Shigeru Kunugi
Pressure-induced change in proteins studied through chemical modifications.
International journal of biological macromolecules 1996;18(4):275-80.
1996: Naoki Tanaka; Shigeru Kunugi
Influence of zinc(II) binding on the structure of bovine alpha-lactalbumin.
International journal of peptide and protein research 1996;47(3):154-60.
1996: Naoki Tanaka; Shigeru Kunugi
Effect of pressure on the deuterium exchange reaction of alpha-lactalbumin and beta-lactoglobulin.
International journal of biological macromolecules 1996;18(1-2):33-9.
1995: Shigeru Kunugi; M Yokoyama; A Sakamoto
Observation of the pre-steady state process in thermolysin catalysis with a fluorescent displacement probe at low pH.
FEBS letters 1995;362(2):189-91.
1992: Shigeru Kunugi
Enzyme reactions under high pressure and their applications.
Annals of the New York Academy of Sciences 1992;672():293-304.
1992: Shigeru Kunugi; Y Murakami; K Ikeda; N Itoh
Chemical modification of proteins under high pressure. Preparation of ferrocene-attached bovine serum albumin and glucose oxidase.
International journal of biological macromolecules 1992;14(4):210-4.