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Volker Adams

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Ulrike Müller; Andreas Oberbach; Gerhard Schuler; Claudia Walther; Maximilian Lauber; Yae Matsuo; Volker Adams
Correlation between endothelial function measured by finger plethysmography in children and HDL-mediated eNOS activation - a preliminary study.
Karla Punkt; Volker Adams; Igor B Buchwalow; Katharina Kandt; Andreas Oberbach; Matthias Blüher
Nitric oxide synthase in skeletal muscle fibers of patients with type 2 diabetes.
Katharina Kackstein; Axel Linke; Norman Mangner; Yasuharu Matsumoto; Sven Möbius-Winkler; Karla Punkt; Gerhard Schuler; Andrej Teren; Volker Adams
Impact of angiotensin II on skeletal muscle metabolism and function in mice: Contribution of IGF-1, Sirtuin-1 and PGC-1α.

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2013: Ulrike Müller; Andreas Oberbach; Gerhard Schuler; Claudia Walther; Maximilian Lauber; Yae Matsuo; Volker Adams
Correlation between endothelial function measured by finger plethysmography in children and HDL-mediated eNOS activation - a preliminary study.
Metabolism: clinical and experimental 2013;62(5):634-7.
2013: Karla Punkt; Volker Adams; Igor B Buchwalow; Katharina Kandt; Andreas Oberbach; Matthias Blüher
Nitric oxide synthase in skeletal muscle fibers of patients with type 2 diabetes.
Acta histochemica 2013;115(4):389-93.
2013: Katharina Kackstein; Axel Linke; Norman Mangner; Yasuharu Matsumoto; Sven Möbius-Winkler; Karla Punkt; Gerhard Schuler; Andrej Teren; Volker Adams
Impact of angiotensin II on skeletal muscle metabolism and function in mice: Contribution of IGF-1, Sirtuin-1 and PGC-1α.
Acta histochemica 2013;115(4):363-70.
2013: Norman Mangner; Yae Matsuo; Gerhard Schuler; Volker Adams
Cachexia in chronic heart failure: endocrine determinants and treatment perspectives.
Endocrine 2013;43(2):253-65.
2013: Karsten Lenk; Sandra Palus; Gerhard Schuler; Robert Schur; Jochen Springer; Stefan Anker; Michael D Culler; Rakesh Datta; Jesse Dong; Volker Adams
Effect of ghrelin and its analogues, BIM-28131 and BIM-28125, on the expression of myostatin in a rat heart failure model.
Journal of cachexia, sarcopenia and muscle 2013;4(1):63-9.
2013: Norman Mangner; Yasuharu Matsumoto; Andreas Oberbach; Marcus Sandri; Gerhard Schuler; Stephan Gielen; Robert Hoellriegel; Yvonne Kullnick; Axel Linke; Volker Adams
Exercise training prevents TNF-α induced loss of force in the diaphragm of mice.
PloS one 2013;8(1):e52274.
2012: Ingo Eitel; Georg Fuernau; Gerhard Schuler; Volker Adams; Suzanne de Waha; Steffen Desch; Patrick Dieterich; Holger Thiele
Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction.
American heart journal 2012;164(5):706-14.
2012: Marcus Sandri; Gerhard Schuler; Daniel Teupser; Joachim Thiery; Volker Adams; Sandra Erbs; Rainer Hambrecht; Robert Höllriegel; Irina Kozarez; Jürgen Kratzsch; Axel Linke; Norman Mangner; Meinhard Mende; Sven Möbius-Winkler; Stephan Gielen
Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study.
European heart journal 2012;33(14):1758-68.
2012: Stephan Gielen; Rainer Hambrecht; Irina Kozarez; Jürgen Kratzsch; Karsten Lenk; Norman Mangner; Marcus Sandri; Gerhard Schuler; Daniel Teupser; Joachim Thiery; Sandra Erbs; Volker Adams
Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging catabolism study.
Circulation 2012;125(22):2716-27.
2012: Karsten Lenk; Axel Linke; Marcus Sandri; Gerhard Schuler; Sven Möbius Winkler; Ephraim Beck; Sandra Erbs; Stephan Gielen; Rainer Hambrecht; Robert Höllriegel; Volker Adams
Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure.
European journal of preventive cardiology 2012;19(3):404-11.
2012: Ephraim B Beck; Matthias Blüher; Sandra Erbs; Rainer Hambrecht; Sven Möbius-Winkler; Friedrich-Wilhelm Mohr; Gerhard Schuler; Michael Stumvoll; Thomas Walther; Felix J Woitek; Volker Adams; Axel Linke
Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease.
European journal of preventive cardiology 2012;19(3):412-8.
2012: Kathrin Landgraf; Tina Ullrich; Jürgen Kratzsch; Volker Adams; Kathrin Dittrich; Sandra Erbs; Daniela Friebe; Gunda Herberth; Wieland Kiess; Antje Körner
Chemerin as a mediator between obesity and vascular inflammation in children.
The Journal of clinical endocrinology and metabolism 2012;97(4):E556-64.
2012: Norman Mangner; Marcus Sandri; Gerhard Schuler; Volker Adams; Rainer Hambrecht; Robert Hoellriegel; Stephan Gielen
Muscle function and running activity in mouse models of hereditary muscle dystrophy: impact of double knockout for dystrophin and the transcription factor MyoD.
Muscle & nerve 2012;45(4):544-51.
2012: Madlen Uhlemann; Gerhard C Schuler; Holger Thiele; Jennifer Adam; Volker Adams; Sandra Erbs; Martin Grunze; Matthias Gutberlet; Thomas Hilberg; Karsten Lenk; Axel Linke; Sven Möbius-Winkler
Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trial.
Trials 2012;13():167.
2012: Florian Schlotter; Gerhard Schuler; Axel Linke; Norman Mangner; Yasuharu Matsumoto; Volker Adams
Regular exercise or changing diet does not influence aortic valve disease progression in LDLR deficient mice.
PloS one 2012;7(5):e37298.
2011: Michal Droppa; Ingo Eitel; Georg Fuernau; Gerhard Schuler; Volker Adams; Patrick Blase; Steffen Desch; Holger Thiele
Impact of N-acetylcysteine on contrast-induced nephropathy defined by cystatin C in patients with ST-elevation myocardial infarction undergoing primary angioplasty.
Clinical research in cardiology : official journal of the German Cardiac Society 2011;100(11):1037-43.
2011: Stephan Gielen; Marcus Sandri; Sandra Erbs; Volker Adams
Exercise-induced modulation of endothelial nitric oxide production.
Current pharmaceutical biotechnology 2011;12(9):1375-84.
2011: Karla Punkt; Tina Kusche; Sophie Günther; Volker Adams; Larry R Jones; Joachim Neumann
Changes in metabolic profile and population of skeletal muscle fibers of mice overexpressing calsequestrin: influence of losartan.
Acta histochemica 2011;113(5):547-55.
2011: Sven Moebius-Winkler; Gerhard Schuler; Volker Adams
Endothelial progenitor cells and exercise-induced redox regulation.
Antioxidants & redox signaling 2011;15(4):997-1011.
2011: Karsten Lenk; Gerhard Schuler; Madlen Uhlemann; Volker Adams
Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;111(1):321-8.
2011: Ingo Eitel; Patrick Blase; Volker Adams; Lysann Hildebrand; Steffen Desch; Gerhard Schuler; Holger Thiele
Growth-differentiation factor 15 as predictor of mortality in acute reperfused ST-elevation myocardial infarction: insights from cardiovascular magnetic resonance.
Heart (British Cardiac Society) 2011;97(8):632-40.
2011: Marcus Sandri; Ephraim Bernhard Beck; Volker Adams; Stephan Gielen; Karsten Lenk; Robert Höllriegel; Norman Mangner; Axel Linke; Sandra Erbs; Sven Möbius-Winkler; Dierk Scheinert; Rainer Hambrecht; Gerhard Schuler
Maximal exercise, limb ischemia, and endothelial progenitor cells.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2011;18(1):55-64.
2011: Sandra Erbs; Ephraim B Beck; Axel Linke; Volker Adams; Stephan Gielen; Nicolle Kraenkel; Sven Möbius-Winkler; Robert Höllriegel; Holger Thiele; Rainer Hambrecht; Gerhard Schuler
High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling--results from a randomized, double-blind, and placebo-controlled study.
International journal of cardiology 2011;146(1):56-63.
2011: Sandra Palus; Robert Schur; Volker Adams; Yoshihiro J Akashi; Stefan D Anker; Barbara Bockmeyer; Michael D Culler; Rakesh Datta; Jesse Dong; Heather Halem; Jochen Springer
Ghrelin and its analogues, BIM-28131 and BIM-28125, improve body weight and regulate the expression of MuRF-1 and MAFbx in a rat heart failure model.
PloS one 2011;6(11):e26865.
2010: Stephan Gielen; Gerhard Schuler; Volker Adams
Cardiovascular effects of exercise training: molecular mechanisms.
Circulation 2010;122(12):1221-38.
2010: Sandra Erbs; Robert Höllriegel; Axel Linke; Ephraim B Beck; Volker Adams; Stephan Gielen; Sven Möbius-Winkler; Marcus Sandri; Nicolle Kraenkel; Rainer Hambrecht; Gerhard Schuler
Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function.
Circulation. Heart failure 2010;3(4):486-94.
2010: Steffen Desch; Daniela Kobler; Johanna Schmidt; Melanie Sonnabend; Volker Adams; Mahdi Sareban; Ingo Eitel; Matthias Blüher; Gerhard Schuler; Holger Thiele
Low vs. higher-dose dark chocolate and blood pressure in cardiovascular high-risk patients.
American journal of hypertension 2010;23(6):694-700.
2010: Holger Thiele; Lysann Hildebrand; Carmen Schirdewahn; Ingo Eitel; Volker Adams; Georg Fuernau; Sandra Erbs; Axel Linke; Klaus-Werner Diederich; Marek Nowak; Steffen Desch; Matthias Gutberlet; Gerhard Schuler
Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-N-ACC (Prospective, Single-Blind, Placebo-Controlled, Randomized Leipzig Immediate PercutaneouS Coronary Intervention Acute Myocardial Infarction N-ACC) Trial.
Journal of the American College of Cardiology 2010;55(20):2201-9.
2010: Ingo Eitel; Marek Nowak; Clemens Stehl; Volker Adams; Georg Fuernau; Lysann Hildebrand; Steffen Desch; Gerhard Schuler; Holger Thiele
Endothelin-1 release in acute myocardial infarction as a predictor of long-term prognosis and no-reflow assessed by contrast-enhanced magnetic resonance imaging.
American heart journal 2010;159(5):882-90.
2010: Sven Möbius-Winkler; Axel Linke; Volker Adams; Gerhard Schuler; Sandra Erbs
How to improve endothelial repair mechanisms: the lifestyle approach.
Expert review of cardiovascular therapy 2010;8(4):573-80.
2010: Yasuharu Matsumoto; Volker Adams; Saskia Jacob; Norman Mangner; Gerhard Schuler; Axel Linke
Regular exercise training prevents aortic valve disease in low-density lipoprotein-receptor-deficient mice.
Circulation 2010;121(6):759-67.
2010: Tatsiana Suvorava; Stephanie Kumpf; Bernhard H Rauch; Vu Thao-Vi Dao; Volker Adams; Georg Kojda
Hydrogen peroxide inhibits exercise-induced increase of circulating stem cells with endothelial progenitor capacity.
Free radical research 2010;44(2):199-207.
2010: Sebastian Sixt; Sebastian Beer; Matthias Blüher; Nicolai Korff; Thomas Peschel; Melanie Sonnabend; Daniel Teupser; Joachim Thiery; Volker Adams; Gerhard Schuler; Josef Niebauer
Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease.
European heart journal 2010;31(1):112-9.
2009: Claudia Walther; Luise Gaede; Volker Adams; Götz Gelbrich; Alexander Leichtle; Sandra Erbs; Melanie Sonnabend; Kati Fikenzer; Antje Körner; Wieland Kiess; Mathias Bruegel; Joachim Thiery; Gerhard Schuler
Effect of increased exercise in school children on physical fitness and endothelial progenitor cells: a prospective randomized trial.
Circulation 2009;120(22):2251-9.
2009: Volker Adams; Sven Möbius-Winkler; Gerhard Schuler
Basic and translational research: from molecule, to mouse, to man.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2009;16 Suppl 2():S48-52.
2009: Holger Thiele; Andreas Schuster; Sandra Erbs; Axel Linke; Karsten Lenk; Volker Adams; Rainer Hambrecht; Gerhard Schuler
Cardiac magnetic resonance imaging at 3 and 15 months after application of circulating progenitor cells in recanalised chronic total occlusions.
International journal of cardiology 2009;135(3):287-95.
2009: Marc Oppermann; Vera Balz; Volker Adams; Vu Thao-Vi Dao; Murat Bas; Tatsiana Suvorava; Georg Kojda
Pharmacological induction of vascular extracellular superoxide dismutase expression in vivo.
Journal of cellular and molecular medicine 2009;13(7):1271-8.
2009: Karsten Lenk; Robert Schur; Axel Linke; Sandra Erbs; Yasuharu Matsumoto; Volker Adams; Gerhard Schuler
Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model.
European journal of heart failure 2009;11(4):342-8.
2009: Yasuharu Matsumoto; Volker Adams; Claudia Walther; Caroline Kleinecke; Peter Brugger; Axel Linke; Thomas Walther; Friedrich-Wilhelm Mohr; Gerhard Schuler
Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair.
European heart journal 2009;30(3):346-55.
2009: Matthias Sauer; Julia Tews; Michael Schwarzer; Joerg Seeburger; Volker Adams; Volkmar Falk; Stefan Dhein; Friedrich-Wilhelm Mohr
Rapid detection of the R389G polymorphism of ADRB1 by real time PCR using fluorescence resonance energy transfer.
Clinical laboratory 2009;55(3-4):128-36.
2009: Volker Adams; Grant A Challen; Ewa Zuba-Surma; Henning Ulrich; György Vereb; Attila Tárnok
Where new approaches can stem from: focus on stem cell identification.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(1):1-3.
2009: Sven Möbius-Winkler; Robert Höllriegel; Gerhard Schuler; Volker Adams
Endothelial progenitor cells: implications for cardiovascular disease.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2009;75(1):25-37.
2008: Volker Adams; Norman Mangner; Alexander Gasch; Christian Krohne; Stephan Gielen; Stephanie Hirner; Hermann-Josef Thierse; Christian C Witt; Axel Linke; Gerhard Schuler; Siegfried Labeit
Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice.
Journal of molecular biology 2008;384(1):48-59.
2008: K Fritzsche; Matthias Blüher; Stefan Schering; Igor B Buchwalow; M Kern; Axel Linke; Andreas Oberbach; Volker Adams; Karla Punkt
Metabolic profile and nitric oxide synthase expression of skeletal muscle fibers are altered in patients with type 1 diabetes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2008;116(10):606-13.
2008: Volker Adams; Axel Linke; Frank Breuckmann; Kirsten Leineweber; Sandra Erbs; Nicolle Kraenkel; Martina Bröcker-Preuss; Felix Woitek; Raimund Erbel; Gerd Heusch; Rainer Hambrecht; Gerhard Schuler; Stefan Möhlenkamp
Circulating progenitor cells decrease immediately after marathon race in advanced-age marathon runners.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2008;15(5):602-7.
2008: Claudia Walther; Volker Adams; Inga Bothur; Kati Drechsler; Sven Fikenzer; Melanie Sonnabend; Beatrice Bublitz; Antje Körner; Sandra Erbs; Martin W Busse; Gerhard Schuler
Increasing physical education in high school students: effects on concentration of circulating endothelial progenitor cells.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2008;15(4):416-22.
2008: Volker Adams; Axel Linke; Stephan Gielen; Sandra Erbs; Rainer Hambrecht; Gerhard Schuler
Modulation of Murf-1 and MAFbx expression in the myocardium by physical exercise training.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2008;15(3):293-9.
2008: Volker Adams; Christian Doring; Gerhard Schuler
Impact of physical exercise on alterations in the skeletal muscle in patients with chronic heart failure.
Frontiers in bioscience : a journal and virtual library 2008;13():302-11.
2007: Alexander Riad; Jing Du; Sebastian Stiehl; Dirk Westermann; Zarah Mohr; Meike Sobirey; Wolfram Doehner; Volker Adams; Matthias Pauschinger; Heinz-Peter Schultheiss; Carsten Tschöpe
Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus.
European journal of pharmacology 2007;569(3):204-11.
2007: Harald Engelhardt; Thomas Meins; Melissa Poynor; Volker Adams; Stephan Nussberger; Wolfram Welte; Kornelius Zeth
High-level expression, refolding and probing the natural fold of the human voltage-dependent anion channel isoforms I and II.
The Journal of membrane biology 2007;216(2-3):93-105.
2007: Volker Adams; Axel Linke; Ulrik Wisloff; Christian Döring; Sandra Erbs; Nicolle Kraenkel; Christian C Witt; Siegfried Labeit; Ursula Müller-Werdan; Gerhard Schuler; Rainer Hambrecht
Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility.
Cardiovascular research 2007;73(1):120-9.
2006: Sandra Erbs; Sven Möbius-Winkler; Axel Linke; Volker Adams; Nicolas Doll; Stephan Gielen; Jan F Gummert; Friedrich-Wilhelm Mohr; Gerhard Schuler; Rainer Hambrecht
Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2006;13(5):826-31.
2006: Stefan Möhlenkamp; Axel Schmermund; Knut Kröger; Gert Kerkhoff; Martina Bröcker-Preuss; Volker Adams; Martin Hensel; David Kiefer; Nils Lehmann; Susanne Moebus; Kirsten Leineweber; Sigrid Elsenbruch; Jörg Barkhausen; Martin Halle; Rainer Hambrecht; Johannes Siegrist; Klaus Mann; Thomas Budde; Karl-Heinz Jöckel; Raimund Erbel
Coronary atherosclerosis and cardiovascular risk in masters male marathon runners. Rationale and design of the "marathon study".
Herz 2006;31(6):575-85.
2006: Andreas Boldt; Markus J Barten; Anja Sagner; Friedrich-Wilhelm Mohr; Volker Adams; Stefan Dhein; Jan F Gummert
The influence of immunosuppressive drugs on T- and B-cell apoptosis via p53-mediated pathway in vitro and in vivo.
Transplantation 2006;82(3):422-7.
2006: Per Magnus Haram; Volker Adams; Ole J Kemi; Alf O Brubakk; Rainer Hambrecht; Oyvind Ellingsen; Ulrik Wisløff
Time-course of endothelial adaptation following acute and regular exercise.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2006;13(4):585-91.
2006: Henning Morawietz; Sandra Erbs; Juergen Holtz; Andreas Schubert; Michael Krekler; Winfried Goettsch; Oliver Kuss; Volker Adams; Karsten Lenk; Friedrich-Wilhelm Mohr; Gerhard Schuler; Rainer Hambrecht
Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trial.
Circulation 2006;114(1 Suppl):I296-301.
2006: Andreas Oberbach; Yvonne Bossenz; Stefanie Lehmann; Josef Niebauer; Volker Adams; Ralf Paschke; Michael R Schön; Matthias Blüher; Karla Punkt
Altered fiber distribution and fiber-specific glycolytic and oxidative enzyme activity in skeletal muscle of patients with type 2 diabetes.
Diabetes care 2006;29(4):895-900.
2005: Sandra Erbs; Axel Linke; Volker Adams; Karsten Lenk; Holger Thiele; Klaus-Werner Diederich; Frank Emmrich; Regine Kluge; Kai Kendziorra; Osama Sabri; Gerhard Schuler; Rainer Hambrecht
Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study.
Circulation research 2005;97(8):756-62.
2005: Marc Dorenkamp; Alexander Riad; Sebastian Stiehl; Frank Spillmann; Dirk Westermann; Jing Du; Matthias Pauschinger; Michel Noutsias; Volker Adams; Heinz-Peter Schultheiss; Carsten Tschöpe
Protection against oxidative stress in diabetic rats: role of angiotensin AT(1) receptor and beta 1-adrenoceptor antagonism.
European journal of pharmacology 2005;520(1-3):179-87.
2005: Karsten Lenk; Volker Adams; Philipp Lurz; Sandra Erbs; Axel Linke; Stephan Gielen; Andrej Schmidt; Dierk Scheinert; Giancarlo Biamino; Frank Emmrich; Gerhard Schuler; Rainer Hambrecht
Therapeutical potential of blood-derived progenitor cells in patients with peripheral arterial occlusive disease and critical limb ischaemia.
European heart journal 2005;26(18):1903-9.
2005: Rainer Hambrecht; P Christian Schulze; Stephan Gielen; Axel Linke; Sven Möbius-Winkler; Sandra Erbs; Jürgen Kratzsch; Andreas Schubert; Volker Adams; Gerhard Schuler
Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2005;12(4):401-6.
2005: Stephan Gielen; Volker Adams; Axel Linke; Sandra Erbs; Sven Möbius-Winkler; Andreas Schubert; Gerhard Schuler; Rainer Hambrecht
Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2005;12(4):393-400.
2005: Dominik Lenz; Karsten Lenk; Anja Mittag; Volker Adams; Nicolle Kraenkel; Andreas Boldt; Andreas O H Gerstner; Martin Raida; T Weiss; Rainer Hambrecht; Attila Tárnok
Detection and quantification of endothelial progenitor cells by flow and laser scanning cytometry.
Journal of biological regulators and homeostatic agents 2005;19(3-4):180-7.
2005: Marcus Sandri; Volker Adams; Stephan Gielen; Axel Linke; Karsten Lenk; Nicolle Kraenkel; Dominik Lenz; Sandra Erbs; Dierk Scheinert; Friedrich-Wilhelm Mohr; Gerhard Schuler; Rainer Hambrecht
Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies.
Circulation 2005;111(25):3391-9.
2005: Axel Linke; Volker Adams; P Christian Schulze; Sandra Erbs; Stephan Gielen; Eduard Fiehn; Sven Möbius-Winkler; Andreas Schubert; Gerhard Schuler; Rainer Hambrecht
Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle.
Circulation 2005;111(14):1763-70.
2005: Nicolle Kraenkel; Volker Adams; Axel Linke; Stephan Gielen; Sandra Erbs; Karsten Lenk; Gerhard Schuler; Rainer Hambrecht
Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cells.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(4):698-703.
2005: Volker Adams; Axel Linke; Nicolle Kraenkel; Sandra Erbs; Stephan Gielen; Sven Möbius-Winkler; Jan F Gummert; Friedrich-Wilhelm Mohr; Gerhard Schuler; Rainer Hambrecht
Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease.
Circulation 2005;111(5):555-62.
2005: Stephan Gielen; Volker Adams; Josef Niebauer; Gerhard Schuler; Rainer Hambrecht
Aging and heart failure--similar syndromes of exercise intolerance? Implications for exercise-based interventions.
Heart failure monitor 2005;4(4):130-6.
2004: P Christian Schulze; Axel Linke; Nina Schoene; Sven Möbius Winkler; Volker Adams; Stefan Conradi; Martin W Busse; Gerhard Schuler; Rainer Hambrecht
Functional and morphological skeletal muscle abnormalities correlate with reduced electromyographic activity in chronic heart failure.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2004;11(2):155-61.
2004: Volker Adams; Karsten Lenk; Axel Linke; Dominik Lenz; Sandra Erbs; Marcus Sandri; Attila Tárnok; Stephan Gielen; Frank Emmrich; Gerhard Schuler; Rainer Hambrecht
Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(4):684-90.
2003: Sandra Erbs; Axel Linke; Stephan Gielen; Eduard Fiehn; Claudia Walther; Jiangtao Yu; Volker Adams; Gerhard Schuler; Rainer Hambrecht
Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2003;10(5):336-44.
2003: Sandra Erbs; Yves Baither; Axel Linke; Volker Adams; Yanwen Shu; Karsten Lenk; Stephan Gielen; Rainer Dilz; Gerhard Schuler; Rainer Hambrecht
Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunction.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(10):1814-9.
2003: Stephan Gielen; Volker Adams; Sven Möbius-Winkler; Axel Linke; Sandra Erbs; Jiangtao Yu; Werner Kempf; Andreas Schubert; Gerhard Schuler; Rainer Hambrecht
Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure.
Journal of the American College of Cardiology 2003;42(5):861-8.
2003: Nicolle Kraenkel; Volker Adams; Stephan Gielen; Axel Linke; Sandra Erbs; Gerhard Schuler; Rainer Hambrecht
Differential gene expression in skeletal muscle after induction of heart failure: impact of cytokines on protein phosphatase 2A expression.
Molecular genetics and metabolism 2003;80(1-2):262-71.
2003: Volker Adams; Ulrike Späte; Nicolle Kraenkel; P Christian Schulze; Axel Linke; Gerhard Schuler; Rainer Hambrecht
Nuclear factor-kappa B activation in skeletal muscle of patients with chronic heart failure: correlation with the expression of inducible nitric oxide synthase.
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 2003;10(4):273-7.
2003: Sandra Erbs; Stephan Gielen; Axel Linke; Sven Möbius-Winkler; Volker Adams; Yves Baither; Gerhard Schuler; Rainer Hambrecht
Improvement of peripheral endothelial dysfunction by acute vitamin C application: different effects in patients with coronary artery disease, ischemic, and dilated cardiomyopathy.
American heart journal 2003;146(2):280-5.
2003: P Christian Schulze; Stephan Gielen; Volker Adams; Axel Linke; Sven Möbius-Winkler; Sandra Erbs; Jürgen Kratzsch; Rainer Hambrecht; Gerhard Schuler
Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulinlike growth factor-I in chronic heart failure.
Basic research in cardiology 2003;98(4):267-74.
2003: Rainer Hambrecht; Volker Adams; Sandra Erbs; Axel Linke; Nicolle Kraenkel; Y Shu; Yves Baither; Stephan Gielen; Holger Thiele; Jan F Gummert; Friedrich-Wilhelm Mohr; Gerhard Schuler
Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase.
Circulation 2003;107(25):3152-8.
2003: Dmitry V Kazakov; Mirka Schmid; Volker Adams; G Cathomas; Beatrix Müller; Guenter Burg; Werner Kempf
HHV-8 DNA sequences in the peripheral blood and skin lesions of an HIV-negative patient with multiple eruptive dermatofibromas: implications for the detection of HHV-8 as a diagnostic marker for Kaposi's sarcoma.
Dermatology (Basel, Switzerland) 2003;206(3):217-21.
2003: P Christian Schulze; Jürgen Kratzsch; Axel Linke; Nina Schoene; Volker Adams; Stephan Gielen; Sandra Erbs; Sven Moebius-Winkler; Gerhard Schuler
Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure.
European journal of heart failure 2003;5(1):33-40.
2002: Werner Kempf; Andreas C Haeffner; Karoline Zepter; Christian Sander; Michael J Flaig; Beatrix Mueller; Renato G Panizzon; Thomas Hardmeier; Volker Adams; Günter Burg
Angiolymphoid hyperplasia with eosinophilia: evidence for a T-cell lymphoproliferative origin.
Human pathology 2002;33(10):1023-9.
2002: Dmitry V Kazakov; Bettina M Prinz; Sonja Michaelis; Mirka Schmid; Beatrix Müller; Volker Adams; Günter Burg; Werner Kempf
Study of HHV-8 DNA sequences in archival biopsies from lesional skin of Kaposi's sarcoma, various mesenchymal tumors and related reactive conditions.
Journal of cutaneous pathology 2002;29(5):279-81.
2002: Rainer Hambrecht; P Christian Schulze; Stephan Gielen; Axel Linke; Sven Möbius-Winkler; Jiangtao Yu; J ürgen Kratzsch J; Gerhard Baldauf; Martin W Busse; Andreas Schubert; Volker Adams; Gerhard Schuler
Reduction of insulin-like growth factor-I expression in the skeletal muscle of noncachectic patients with chronic heart failure.
Journal of the American College of Cardiology 2002;39(7):1175-81.
2002: Volker Adams; Britta Nehrhoff; Ulrike Späte; Axel Linke; P Christian Schulze; Angelika Baur; Stephan Gielen; Rainer Hambrecht; Gerhard Schuler
Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study.
Cardiovascular research 2002;54(1):95-104.
2002: P Christian Schulze; Volker Adams; Christoph Busert; Martin Bettag; Thomas Kahn; Ralf Schober
Effects of laser-induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors.
Lasers in surgery and medicine 2002;30(3):227-32.
2001: Volker Adams; Karsten Lenk; A Schubert; Stephan Gielen; Gerhard Schuler; Rainer Hambrecht
Differentially expressed genes in L6 rat skeletal muscle myoblasts after incubation with inflammatory cytokines.
Cytokine 2001;13(6):342-8.
2001: Volker Adams; Stephan Gielen; Rainer Hambrecht; Gerhard Schuler
Apoptosis in skeletal muscle.
Frontiers in bioscience : a journal and virtual library 2001;6():D1-D11.
2000: Werner Kempf; Beatrix Müller; R Maurer; Volker Adams; Gabriella Campadelli-Fiume
Increased expression of human herpesvirus 7 in lymphoid organs of AIDS patients.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2000;16(3):193-201.
1999: Robert Koesters; Volker Adams; D Betts; R Moos; M Schmid; A Siermann; S Hassam; S Weitz; Peter Lichter; P U Heitz; M von Knebel Doeberitz; Jakob Briner
Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression.
Genomics 1999;61(2):210-8.
1999: Oleg I Tchernitsa; Johannes Zuber; Christine Sers; R Brinckmann; S K Britsch; Volker Adams; Reinhold Schäfer
Gene expression profiling of fibroblasts resistant toward oncogene-mediated transformation reveals preferential transcription of negative growth regulators.
Oncogene 1999;18(39):5448-54.
1999: Werner Kempf; Volker Adams; Martin Kleinhans; Guenter Burg; Renato G Panizzon; Gabriella Campadelli-Fiume; Frank O Nestle
Pityriasis rosea is not associated with human herpesvirus 7.
Archives of dermatology 1999;135(9):1070-2.
1999: Robert Koesters; Ruediger Ridder; A Kopp-Schneider; D Betts; Volker Adams; Felix K Niggli; Jakob Briner; Magnus von Knebel Doeberitz
Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumors.
Cancer research 1999;59(16):3880-2.
1999: Volker Adams; H Jiang; Jiangtao Yu; Sven Möbius-Winkler; Eduard Fiehn; Axel Linke; C Weigl; Gerhard Schuler; Rainer Hambrecht
Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance.
Journal of the American College of Cardiology 1999;33(4):959-65.
1999: Werner Kempf; C Perniciaro; Volker Adams; Beatrix Mueller; Guenter Burg
Human herpesvirus 8 (HHV-8) in familial Kaposi's sarcoma.
Experimental dermatology 1999;8(1):68-70.
1999: Volker Adams; Sonja Schmid; Maimoona A Zariwala; M Schmid; P Kleihues; J Briner; R Schäfer
Prevalence of human papilloma virus DNA in head and neck cancers carrying wild-type or mutant p53 tumor suppressor genes.
Anticancer research 1999;19(1A):1-6.
1999: Rainer Hambrecht; Volker Adams; Stephan Gielen; Axel Linke; Sven Möbius-Winkler; Jiangtao Yu; Josef Niebauer; H Jiang; Eduard Fiehn; Gerhard Schuler
Exercise intolerance in patients with chronic heart failure and increased expression of inducible nitric oxide synthase in the skeletal muscle.
Journal of the American College of Cardiology 1999;33(1):174-9.
1998: Rainer Hambrecht; Eduard Fiehn; C Weigl; Stephan Gielen; C Hamann; Ralf Kaiser; Jiangtao Yu; Volker Adams; Josef Niebauer; Gerhard Schuler
Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure.
Circulation 1998;98(24):2709-15.
1998: Werner Kempf; Volker Adams; Prisco Mirandola; Laura Menotti; Dario Di Luca; N Wey; Beatrix Müller; Gabriella Campadelli-Fiume
Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen.
The Journal of infectious diseases 1998;178(3):841-5.
1998: Volker Adams; S Krabbes; H Jiang; J Yu; B Flott; Stephan Gielen; Gerhard Schuler; Rainer Hambrecht
Complete coding sequence of inducible nitric oxide synthase from human heart and skeletal muscle of patients with chronic heart failure.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 1998;2(4):242-9.
1997: Karla Punkt; Volker Adams; Axel Linke; K Welt
The correlation of cytophotometrically and biochemically measured enzyme activities: changes in the myocardium of diabetic and hypoxic diabetic rats, with and without Ginkgo biloba extract treatment.
Acta histochemica 1997;99(3):291-9.
1997: Volker Adams; Jiangtao Yu; Sven Möbius-Winkler; Axel Linke; C Weigl; L Hilbrich; Gerhard Schuler; Rainer Hambrecht
Increased inducible nitric oxide synthase in skeletal muscle biopsies from patients with chronic heart failure.
Biochemical and molecular medicine 1997;61(2):152-60.
1997: Werner Kempf; Volker Adams; N Wey; R Moos; Mirka Schmid; Elisa Avitabile; Gabriella Campadelli-Fiume
CD68+ cells of monocyte/macrophage lineage in the environment of AIDS-associated and classic-sporadic Kaposi sarcoma are singly or doubly infected with human herpesviruses 7 and 6B.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7600-5.
1997: W Guo; Volker Adams; J Mason; Edward R B McCabe
Identification of a ferritin light chain pseudogene near the glycerol kinase locus in Xp21 by cDNA amplification for identification of genomic expressed sequences.
Biochemical and molecular medicine 1997;60(2):169-73.
1997: Rainer Hambrecht; Eduard Fiehn; Jiangtao Yu; Josef Niebauer; C Weigl; L Hilbrich; Volker Adams; U Riede; Gerhard Schuler
Effects of endurance training on mitochondrial ultrastructure and fiber type distribution in skeletal muscle of patients with stable chronic heart failure.
Journal of the American College of Cardiology 1997;29(5):1067-73.
1996: Werner Kempf; Volker Adams
Viruses in the pathogenesis of Kaposi's sarcoma--a review.
Biochemical and molecular medicine 1996;58(1):1-12.
1996: Volker Adams; M A Hany; M Schmid; S Hassam; J Briner; Felix K Niggli
Detection of t(11;22)(q24;q12) translocation breakpoint in paraffin-embedded tissue of the Ewing's sarcoma family by nested reverse transcription-polymerase chain reaction.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 1996;5(2):107-13.
1996: Volker Adams; C Moll; M Schmid; C Rodrigues; R Moos; J Briner
Detection and typing of human papillomavirus in biopsy and cytological specimens by polymerase chain reaction and restriction enzyme analysis: a method suitable for semiautomation.
Journal of medical virology 1996;48(2):161-70.
1996: Jann Lübbe; A Kormann; Volker Adams; S Hassam; K W Grätz; Renato G Panizzon; Guenter Burg
HPV-11- and HPV-16-associated oral verrucous carcinoma.
Dermatology (Basel, Switzerland) 1996;192(3):217-21.
1995: Volker Adams; Werner Kempf; M Schmid; B Müller; J Briner; G Burg
Absence of herpesvirus-like DNA sequences in skin cancers of non-immunosuppressed patients.
Lancet 1995;346(8991-8992):1715-6.
1995: Kevin McCabe; David A Wheeler; Volker Adams; Edward RB McCabe
Comparison of human VDAC1 with streptococcal streptokinase and bovine bactericidal permeability increasing protein: role of structural information in identifying functionally significant domains.
Biochemical and molecular medicine 1995;56(2):176-9.
1995: Werner Kempf; Volker Adams; M Pfaltz; J Briner; M Schmid; R Moos; S Hassam
Human herpesvirus type 6 and cytomegalovirus in AIDS-associated Kaposi's sarcoma: no evidence for an etiological association.
Human pathology 1995;26(8):914-9.
1995: Volker Adams; Werner Kempf; S Hassam; J Briner; M Schmid; R Moos; M Pfaltz
Detection of several types of human papilloma viruses in AIDS-associated Kaposi's sarcoma.
Journal of medical virology 1995;46(3):189-93.
1995: Volker Adams; Werner Kempf; S Hassam; J Briner
Determination of hexokinase isoenzyme I and II composition by RT-PCR: increased hexokinase isoenzyme II in human renal cell carcinoma.
Biochemical and molecular medicine 1995;54(1):53-8.
1994: S M Gray; Volker Adams; Y Yamashita; S P Le; Jan Goddard-Finegold; Edward RB McCabe
Hexokinase binding in ischemic and reperfused piglet brain.
Biochemical medicine and metabolic biology 1994;53(2):145-8.
1994: Paul Komminoth; Volker Adams; A A Long; Jürgen Roth; Parvin Saremaslani; Renata Flury; M Schmid; Philipp U Heitz
Evaluation of methods for hepatitis C virus detection in archival liver biopsies. Comparison of histology, immunohistochemistry, in-situ hybridization, reverse transcriptase polymerase chain reaction (RT-PCR) and in-situ RT-PCR.
Pathology, research and practice 1994;190(11):1017-25.
1994: Volker Adams; A Schieber; Edward RB McCabe
Hexokinase autophosphorylation: identification of a new dual specificity protein kinase.
Biochemical medicine and metabolic biology 1994;53(1):80-6.
1994: Werner Kempf; Volker Adams; S Hassam; M Schmid; R Moos; J Briner; M Pfaltz
[Detection of human herpesvirus type 6, human herpesvirus type 7, cytomegalovirus and human papillomavirus in cutaneous AIDS-associated Kaposi's sarcoma].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1994;78():260-4.
1994: Paul Komminoth; Volker Adams; A A Long; Jürgen Roth; Parvin Saremaslani; Renata Flury; M Schmid; Philipp U Heitz
[Comparison of histology, immunohistochemistry, RT-PCR, in situ hybridization, and in situ RT-PCR for demonstration of hepatitis C virus in paraffin-embedded liver biopsies].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1994;78():220-5.
1993: W Guo; K Worley; Volker Adams; J Mason; D Sylvester-Jackson; Y H Zhang; Jeffrey A Towbin; D D Fogt; S Madu; David A Wheeler
Genomic scanning for expressed sequences in Xp21 identifies the glycerol kinase gene.
Nature genetics 1993;4(4):367-72.
1993: K C Worley; K A Ellison; Y H Zhang; D F Wang; J Mason; E J Roth; Volker Adams; D D Fogt; X M Zhu; Jeffrey A Towbin
Yeast artificial chromosome cloning in the glycerol kinase and adrenal hypoplasia congenita region of Xp21.
Genomics 1993;16(2):407-16.
1992: B D Gelb; K C Worley; L D Griffin; Volker Adams; A Craig Chinault; Edward RB McCabe
Characterization of human genomic yeast artificial chromosome inserts containing hexokinase 1 coding information on chromosome 10.
Biochemical medicine and metabolic biology 1992;47(3):265-9.
1992: L D Griffin; B D Gelb; Volker Adams; Edward RB McCabe
Developmental expression of hexokinase 1 in the rat.
Biochimica et biophysica acta 1992;1129(3):309-17.
1992: B D Gelb; Volker Adams; Stephen N Jones; L D Griffin; G R MacGregor; Edward RB McCabe
Targeting of hexokinase 1 to liver and hepatoma mitochondria.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(1):202-6.
1991: L D Griffin; B D Gelb; David A Wheeler; D Davison; Volker Adams; Edward RB McCabe
Mammalian hexokinase 1: evolutionary conservation and structure to function analysis.
Genomics 1991;11(4):1014-24.
1991: Volker Adams; L D Griffin; B D Gelb; E R McCabe
Protein kinase activity of rat brain hexokinase.
Biochemical and biophysical research communications 1991;177(3):1101-6.
1991: Volker Adams; L Griffin; Jeffrey A Towbin; B Gelb; K Worley; E R McCabe
Porin interaction with hexokinase and glycerol kinase: metabolic microcompartmentation at the outer mitochondrial membrane.
Biochemical medicine and metabolic biology 1991;45(3):271-91.
1991: K Bücheler; Volker Adams; Dieter Brdiczka
Localization of the ATP/ADP translocator in the inner membrane and regulation of contact sites between mitochondrial envelope membranes by ADP. A study on freeze-fractured isolated liver mitochondria.
Biochimica et biophysica acta 1991;1056(3):233-42.
1991: M Kottke; Volker Adams; Theo Wallimann; V K Nalam; Dieter Brdiczka
Location and regulation of octameric mitochondrial creatine kinase in the contact sites.
Biochimica et biophysica acta 1991;1061(2):215-25.
1990: Dieter Brdiczka; K Bücheler; M Kottke; Volker Adams; V K Nalam
Characterization and metabolic function of mitochondrial contact sites.
Biochimica et biophysica acta 1990;1018(2-3):234-8.
1989: Jeffrey A Towbin; M Minter; Dieter Brdiczka; Volker Adams; Vito De Pinto; F Palmieri; E R McCabe
Demonstration and characterization of human cardiac porin: a voltage-dependent channel involved in adenine nucleotide movement across the outer mitochondrial membrane.
Biochemical medicine and metabolic biology 1989;42(2):161-9.
1989: Volker Adams; W Bosch; J Schlegel; Theo Wallimann; Dieter Brdiczka
Further characterization of contact sites from mitochondria of different tissues: topology of peripheral kinases.
Biochimica et biophysica acta 1989;981(2):213-25.
1988: Volker Adams; W Bosch; T Hämmerle; Dieter Brdiczka
Activation of low Km hexokinases in purified hepatocytes by binding to mitochondria.
Biochimica et biophysica acta 1988;932(2):195-205.
1988: Lech Wojtczak; Volker Adams; Dieter Brdiczka
Effect of oleate on the apparent Km of monoamine oxidase and the amount of membrane-bound hexokinase in isolated rat hepatocytes: further evidence for the controlling role of the surface charge in hexokinase binding.
Molecular and cellular biochemistry 1988;79(1):25-30.
1986: K Ohlendieck; I Riesinger; Volker Adams; J Krause; Dieter Brdiczka
Enrichment and biochemical characterization of boundary membrane contact sites from rat-liver mitochondria.
Biochimica et biophysica acta 1986;860(3):672-89.