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Brigitte Kunze

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Christin Osteresch; Paultheo von Zezschwitz; Tobias Bender; Stephanie Grond; Markus Huss; Rolf Jansen; Brigitte Kunze; Helmut Wieczorek
The binding site of the V-ATPase inhibitor apicularen is in the vicinity of those for bafilomycin and archazolid.
Gerhard Höfle; Brigitte Kunze; Edgar Forche; Klaus Gerth; Hans Reichenbach; Florenz Sasse; Evgeny V Prusov
Isolation, biological activity evaluation, structure elucidation, and total synthesis of eliamid: a novel complex I inhibitor.
Michael Reck; Katrin Rutz; Stefan Schulz; Subhash Kumar Surapaneni; Jürgen Tomasch; Brigitte Kunze; Irene Wagner-Döbler
The biofilm inhibitor carolacton disturbs membrane integrity and cell division of Streptococcus mutans through the serine/threonine protein kinase PknB.

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All Publications

2012: Christin Osteresch; Paultheo von Zezschwitz; Tobias Bender; Stephanie Grond; Markus Huss; Rolf Jansen; Brigitte Kunze; Helmut Wieczorek
The binding site of the V-ATPase inhibitor apicularen is in the vicinity of those for bafilomycin and archazolid.
The Journal of biological chemistry 2012;287(38):31866-76.
2012: Gerhard Höfle; Brigitte Kunze; Edgar Forche; Klaus Gerth; Hans Reichenbach; Florenz Sasse; Evgeny V Prusov
Isolation, biological activity evaluation, structure elucidation, and total synthesis of eliamid: a novel complex I inhibitor.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(36):11362-70.
2011: Michael Reck; Katrin Rutz; Stefan Schulz; Subhash Kumar Surapaneni; Jürgen Tomasch; Brigitte Kunze; Irene Wagner-Döbler
The biofilm inhibitor carolacton disturbs membrane integrity and cell division of Streptococcus mutans through the serine/threonine protein kinase PknB.
Journal of bacteriology 2011;193(20):5692-706.
2010: Brigitte Kunze; Michael Reck; Andreas Dötsch; André Lemme; Dietmar Schummer; Herbert Irschik; Heinrich Steinmetz; Irene Wagner-Döbler
Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum.
BMC microbiology 2010;10():199.
2008: Gerhard Höfle; Brigitte Kunze
Biosynthesis of aurachins A-L in Stigmatella aurantiaca: a feeding study.
Journal of natural products 2008;71(11):1843-9.
2008: Gerhard Höfle; Bettina Bööhlendorf; Thomas Fecker; Florenz Sasse; Brigitte Kunze
Semisynthesis and antiplasmodial activity of the quinoline alkaloid aurachin E.
Journal of natural products 2008;71(11):1967-9.
2008: Brigitte Kunze; Bettina Böhlendorf; Hans Reichenbach; Gerhard Höfle
Pedein A and B: production, isolation, structure elucidation and biological properties of new antifungal cyclopeptides from Chondromyces pediculatus (Myxobacteria).
The Journal of antibiotics 2008;61(1):18-26.
2007: Brigitte Kunze; Florenz Sasse; Helmut Wieczorek; Markus Huss
Cruentaren A, a highly cytotoxic benzolactone from Myxobacteria is a novel selective inhibitor of mitochondrial F1-ATPases.
FEBS letters 2007;581(18):3523-7.
2007: Heinrich Steinmetz; Herbert Irschik; Brigitte Kunze; Hans Reichenbach; Gerhard Höfle; Rolf Jansen
Thuggacins, macrolide antibiotics active against Mycobacterium tuberculosis: isolation from myxobacteria, structure elucidation, conformation analysis and biosynthesis.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(20):5822-32.
2007: Axel Sandmann; Jeroen S Dickschat; Holger Jenke-Kodama; Brigitte Kunze; Elke Dittmann; Rolf Müller
A Type II polyketide synthase from the gram-negative Bacterium Stigmatella aurantiaca is involved in Aurachin alkaloid biosynthesis.
Angewandte Chemie (International ed. in English) 2007;46(15):2712-6.
2006: Brigitte Kunze; Heinrich Steinmetz; Gerhard Höfle; Markus Huss; Helmut Wieczorek; Hans Reichenbach
Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (myxobacteria) with inhibitory effect on mitochondrial ATPase activity. Fermentation and biological properties.
The Journal of antibiotics 2006;59(10):664-8.
2006: Inga Müller; Stefan Weinig; Heinrich Steinmetz; Brigitte Kunze; Sheeba Veluthoor; Taifo Mahmud; Rolf Müller
A unique mechanism for methyl ester formation via an amide intermediate found in myxobacteria.
Chembiochem : a European journal of chemical biology 2006;7(8):1197-205.
2006: Shwan Rachid; Daniel Krug; Brigitte Kunze; Irene Kochems; Maren Scharfe; T Mark Zabriskie; Helmut Blöcker; Rolf Müller
Molecular and biochemical studies of chondramide formation-highly cytotoxic natural products from Chondromyces crocatus Cm c5.
Chemistry & biology 2006;13(6):667-81.
2005: Brigitte Kunze; Hans Reichenbach; Rolf Müller; Gerhard Höfle
Aurafuron A and B, new bioactive polyketides from Stigmatella aurantiaca and Archangium gephyra (Myxobacteria). Fermentation, isolation, physico-chemical properties, structure and biological activity.
The Journal of antibiotics 2005;58(4):244-51.
2005: Nikolaos Gaitatzis; Brigitte Kunze; Rolf Müller
Novel insights into siderophore formation in myxobacteria.
Chembiochem : a European journal of chemical biology 2005;6(2):365-74.
2005: Silke C Wenzel; Brigitte Kunze; Gerhard Höfle; Barbara Silakowski; Maren Scharfe; Helmut Blöcker; Rolf Müller
Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis.
Chembiochem : a European journal of chemical biology 2005;6(2):375-85.
2005: Markus Huss; Florenz Sasse; Brigitte Kunze; Rolf Jansen; Heinrich Steinmetz; Gudrun Ingenhorst; Axel Zeeck; Helmut Wieczorek
Archazolid and apicularen: novel specific V-ATPase inhibitors.
BMC biochemistry 2005;6():13.
2004: Brigitte Kunze; Rolf Jansen; Gerhard Höfle; Hans Reichenbach
Ajudazols, new inhibitors of the mitochondrial electron transport from Chondromyces crocatus. Production, antimicrobial activity and mechanism of action.
The Journal of antibiotics 2004;57(2):151-5.
2003: Florenz Sasse; Thomas Leibold; Brigitte Kunze; Gerhard Höfle; Hans Reichenbach
Cyrmenins, new beta-methoxyacrylate inhibitors of the electron transport. Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 2003;56(10):827-31.
2002: Nikolaos Gaitatzis; Barbara Silakowski; Brigitte Kunze; Gabriele Nordsiek; Helmut Blöcker; Gerhard Höfle; Rolf Müller
The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase.
The Journal of biological chemistry 2002;277(15):13082-90.
2001: Nikolaos Gaitatzis; Brigitte Kunze; Rolf Müller
In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11136-41.
2001: Barbara Silakowski; Brigitte Kunze; Rolf Müller
Multiple hybrid polyketide synthase/non-ribosomal peptide synthetase gene clusters in the myxobacterium Stigmatella aurantiaca.
Gene 2001;275(2):233-40.
2001: Barbara Silakowski; Gabriele Nordsiek; Brigitte Kunze; Helmut Blöcker; Rolf Müller
Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15.
Chemistry & biology 2001;8(1):59-69.
2000: Barbara Silakowski; Brigitte Kunze; Gabriele Nordsiek; Helmut Blöcker; Gerhard Höfle; Rolf Müller
The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15.
European journal of biochemistry / FEBS 2000;267(21):6476-85.
2000: Barbara Silakowski; Brigitte Kunze; Rolf Müller
Stigmatella aurantiaca Sg a15 carries genes encoding type I and type II 3-deoxy-D-arabino-heptulosonate-7-phosphate synthases: involvement of a type II synthase in aurachin biosynthesis.
Archives of microbiology 2000;173(5-6):403-11.
1999: Barbara Silakowski; HU Schairer; H Ehret; Brigitte Kunze; Stefan Weinig; Gabriele Nordsiek; P Brandt; Helmut Blöcker; Gerhard Höfle; Stefan Beyer; Rolf Müller
New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.
The Journal of biological chemistry 1999;274(52):37391-9.
1999: Florenz Sasse; B Böhlendorf; M Herrmann; Brigitte Kunze; E Forche; Heinrich Steinmetz; Gerhard Höfle; Hans Reichenbach; M Hermann
Melithiazols, new beta-methoxyacrylate inhibitors of the respiratory chain isolated from myxobacteria. Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1999;52(8):721-9.
1999: Stefan Beyer; Brigitte Kunze; Barbara Silakowski; Rolf Müller
Metabolic diversity in myxobacteria: identification of the myxalamid and the stigmatellin biosynthetic gene cluster of Stigmatella aurantiaca Sg a15 and a combined polyketide-(poly)peptide gene cluster from the epothilone producing strain Sorangium cellulosum So ce90.
Biochimica et biophysica acta 1999;1445(2):185-95.
1998: Brigitte Kunze; Rolf Jansen; Florenz Sasse; Gerhard Höfle; Hans Reichenbach
Apicularens A and B, new cytostatic macrolides from Chondromyces species (myxobacteria): production, physico-chemical and biological properties.
The Journal of antibiotics 1998;51(12):1075-80.
1998: Florenz Sasse; Brigitte Kunze; Thomas Gronewold; H Reichenbach
The chondramides: cytostatic agents from myxobacteria acting on the actin cytoskeleton.
Journal of the National Cancer Institute 1998;90(20):1559-63.
1995: Brigitte Kunze; R Jansen; Florenz Sasse; Gerhard Höfle; Hans Reichenbach
Chondramides A approximately D, new antifungal and cytostatic depsipeptides from Chondromyces crocatus (myxobacteria). Production, physico-chemical and biological properties.
The Journal of antibiotics 1995;48(11):1262-6.
1994: Brigitte Kunze; R Jansen; Gerhard Höfle; Hans Reichenbach
Crocacin, a new electron transport inhibitor from Chondromyces crocatus (myxobacteria). Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1994;47(8):881-6.
1994: Thorsten Friedrich; Tomoko Ohnishi; E Forche; Brigitte Kunze; R Jansen; W Trowitzsch; Gerhard Höfle; Hans Reichenbach; Hanns Weiss
Two binding sites for naturally occurring inhibitors in mitochondrial and bacterial NADH:ubiquinone oxidoreductase (complex I).
Biochemical Society transactions 1994;22(1):226-30.
1994: Thorsten Friedrich; P van Heek; H Leif; Tomoko Ohnishi; E Forche; Brigitte Kunze; R Jansen; W Trowitzsch-Kienast; Gerhard Höfle; Hans Reichenbach
Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase.
European journal of biochemistry / FEBS 1994;219(1-2):691-8.
1993: Brigitte Kunze; R Jansen; L Pridzun; E Jurkiewicz; G Hunsmann; Gerhard Höfle; Hans Reichenbach
Thiangazole, a new thiazoline antibiotic from Polyangium sp. (myxobacteria): production, antimicrobial activity and mechanism of action.
The Journal of antibiotics 1993;46(11):1752-5.
1992: Brigitte Kunze; R Jansen; L Pridzun; E Jurkiewicz; G Hunsmann; Gerhard Höfle; Hans Reichenbach
Phenoxan, a new oxazole-pyrone from myxobacteria: production, antimicrobial activity and its inhibition of the electron transport in complex I of the respiratory chain.
The Journal of antibiotics 1992;45(9):1549-52.
1992: Brigitte Kunze; W Trowitzsch-Kienast; Gerhard Höfle; Hans Reichenbach
Nannochelins A, B and C, new iron-chelating compounds from Nannocystis exedens (myxobacteria). Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1992;45(2):147-50.
1989: Brigitte Kunze; N Bedorf; W Kohl; Gerhard Höfle; Hans Reichenbach
Myxochelin A, a new iron-chelating compound from Angiococcus disciformis (Myxobacterales). Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1989;42(1):14-7.
1987: Brigitte Kunze; Gerhard Höfle; Hans Reichenbach
The aurachins, new quinoline antibiotics from myxobacteria: production, physico-chemical and biological properties.
The Journal of antibiotics 1987;40(3):258-65.
1985: Brigitte Kunze; W Kohl; Gerhard Höfle; Hans Reichenbach
Production, isolation, physico-chemical and biological properties of angiolam A, a new antibiotic from Angiococcus disciformis (Myxobacterales).
The Journal of antibiotics 1985;38(12):1649-54.
1984: Brigitte Kunze; T Kemmer; Gerhard Höfle; Hans Reichenbach
Stigmatellin, a new antibiotic from Stigmatella aurantiaca (Myxobacterales). I. Production, physico-chemical and biological properties.
The Journal of antibiotics 1984;37(5):454-61.
1983: K Gerth; R Jansen; G Reifenstahl; Gerhard Höfle; H Irschik; Brigitte Kunze; Hans Reichenbach; G Thierbach
The myxalamids, new antibiotics from Myxococcus xanthus (Myxobacterales). I. Production, physico-chemical and biological properties, and mechanism of action.
The Journal of antibiotics 1983;36(9):1150-6.
1982: Brigitte Kunze; Hans Reichenbach; H Augustiniak; Gerhard Höfle
Isolation and identification of althiomycin from Cystobacter fuscus (myxobacterales).
The Journal of antibiotics 1982;35(5):635-6.