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Ralf Küppers

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Felicia Anna Tucci; Joerg F Schlaak; Ruth Broering; Patricia Johansson; Ralf Küppers
B cells in chronically hepatitis C virus-infected individuals lack a virus-induced mutation signature in the TP53, CTNNB1, and BCL6 genes.
V Bohle; C Döring; Martin-Leo Hansmann; Ralf Küppers
Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma.
Ralf Küppers; Markus Schneider; Martin-Leo Hansmann
Laser-based microdissection of single cells from tissue sections and PCR analysis of rearranged immunoglobulin genes from isolated normal and malignant human B cells.

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2013: Felicia Anna Tucci; Joerg F Schlaak; Ruth Broering; Patricia Johansson; Ralf Küppers
B cells in chronically hepatitis C virus-infected individuals lack a virus-induced mutation signature in the TP53, CTNNB1, and BCL6 genes.
Journal of virology 2013;87(5):2956-62.
2013: V Bohle; C Döring; Martin-Leo Hansmann; Ralf Küppers
Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma.
Leukemia 2013;27(3):671-9.
2013: Ralf Küppers; Markus Schneider; Martin-Leo Hansmann
Laser-based microdissection of single cells from tissue sections and PCR analysis of rearranged immunoglobulin genes from isolated normal and malignant human B cells.
Methods in molecular biology (Clifton, N.J.) 2013;971():49-63.
2013: Marc Seifert; René Scholtysik; Ralf Küppers
Origin and pathogenesis of B cell lymphomas.
Methods in molecular biology (Clifton, N.J.) 2013;971():1-25.
2012: Enrico Tiacci; Carel J M van Noesel; Wolfram Klapper; Ralf Küppers; Gunhild Mechtersheimer; Verena Brune; Claudia Döring; Brunangelo Falini; Martin-Leo Hansmann
Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma.
Blood 2012;120(23):4609-20.
2012: Marc Seifert; Ludger Sellmann; Stephan Stilgenbauer; Frederik Wein; Johannes Bloehdorn; Jan Dürig; Ralf Küppers
Cellular origin and pathophysiology of chronic lymphocytic leukemia.
The Journal of experimental medicine 2012;209(12):2183-98.
2012: Johannes M Heuckmann; Lukas Heukamp; Mirjam Koker; Ralf Küppers; Christine M Lovly; Florian Malchers; Lydia Meder; William Pao; Martin Peifer; Martin L Sos; Hyatt Balke-Want; Roman K Thomas
Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(17):4682-90.
2012: René Scholtysik; Carsten Schwaenen; Reiner Siebert; Lorenz Trümper; Inga Vater; Swen Wessendorf; Maciej Giefing; Markus Kreuz; Markus Loeffler; Inga Nagel; Ralf Küppers
Recurrent deletions of the TNFSF7 and TNFSF9 genes in 19p13.3 in diffuse large B-cell and Burkitt lymphomas.
International journal of cancer. Journal international du cancer 2012;131(5):E830-5.
2012: Ludger Sellmann; Dörte Siemer; Jens Stanelle; Holger Nückel; René Scholtysik; Alexander Carpinteiro; Ulrich Dührsen; Jan Dürig; Ludger Klein-Hipass; Dieter Kube; Ralf Küppers
p53 protein expression in chronic lymphocytic leukemia.
Leukemia & lymphoma 2012;53(7):1282-8.
2012: Claudia Otto; Julia Richter; Matthias Schlesner; Reiner Siebert; Inga Vater; Stefan Gesk; Maciej Giefing; Martin-Leo Hansmann; Wolfram Klapper; Anne Massow; Ralf Küppers
Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma.
British journal of haematology 2012;157(6):702-8.
2012: Ralf Küppers
New insights in the biology of Hodgkin lymphoma.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2012;2012():328-34.
2011: Ralf Küppers
CCR7 & lymphotoxin in lymphoma niche.
Blood 2011;118(4):831-2.
2011: Ralf Küppers
NPAT mutations in Hodgkin lymphoma.
Blood 2011;118(3):484-5.
2011: Claudia Philipp; Jennifer Edelmann; Andreas Bühler; Dirk Winkler; Stephan Stilgenbauer; Ralf Küppers
Mutation analysis of the TNFAIP3 (A20) tumor suppressor gene in CLL.
International journal of cancer. Journal international du cancer 2011;128(7):1747-50.
2011: Ludger Sellmann; Dirk de Beer; Marius Bartels; Bertram Opalka; Holger Nückel; Ulrich Dührsen; Jan Dürig; Marc Seifert; Dörte Siemer; Ralf Küppers; Gabriela M Baerlocher; Alexander Röth
Telomeres and prognosis in patients with chronic lymphocytic leukaemia.
International journal of hematology 2011;93(1):74-82.
2010: Ludger Sellmann; Rene Scholtysik; Markus Kreuz; Sandra Cyrull; Enrico Tiacci; Jens Stanelle; Alexander Carpinteiro; Holger Nückel; Tanja Boes; Stefan Gesk; Reiner Siebert; Ludger Klein-Hitpass; Ulrich Dührsen; Jan Dürig; Ralf Küppers
Gene dosage effects in chronic lymphocytic leukemia.
Cancer genetics and cytogenetics 2010;203(2):149-60.
2010: René Scholtysik; Markus Kreuz; Wolfram Klapper; Birgit Burkhardt; Alfred C Feller; Michael Hummel; Markus Loeffler; Maciej Rosolowski; Carsten Schwaenen; Rainer Spang; Harald Stein; Christoph Thorns; Lorenz Trümper; Inga Vater; Swen Wessendorf; Thorsten Zenz; Reiner Siebert; Ralf Küppers
Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis.
Haematologica 2010;95(12):2047-55.
2010: Jens Stanelle; Claudia Döring; Martin-Leo Hansmann; Ralf Küppers
Mechanisms of aberrant GATA3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cells.
Blood 2010;116(20):4202-11.
2010: Manuel Montesinos-Rongen; Roland Schmitz; Anna Brunn; Stefan Gesk; Julia Richter; Ke Hong; Otmar D Wiestler; Reiner Siebert; Ralf Küppers; Martina Deckert
Mutations of CARD11 but not TNFAIP3 may activate the NF-kappaB pathway in primary CNS lymphoma.
Acta neuropathologica 2010;120(4):529-35.
2010: Annette Schmidt; Roland Schmitz; Maciej Giefing; Jose Ignacio Martin-Subero; Stefan Gesk; Inga Vater; Anne Massow; Ewerton Maggio; Markus Schneider; Martin-Leo Hansmann; Reiner Siebert; Ralf Küppers
Rare occurrence of biallelic CYLD gene mutations in classical Hodgkin lymphoma.
Genes, chromosomes & cancer 2010;49(9):803-9.
2010: Holger Nückel; M Switala; Ludger Sellmann; P A Horn; Jan Dürig; Ulrich Dührsen; Ralf Küppers; Hans Grosse-Wilde; Vera Rebmann
The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia.
Leukemia 2010;24(6):1152-9.
2010: Ralf Küppers
Side population cells in Hodgkin lymphoma.
Leukemia & lymphoma 2010;51(5):741-2.
2010: Claudia Müller; Dörte Siemer; Götz Lehnerdt; Stephan Lang; Ralf Küppers
Molecular analysis of IgD-positive human germinal centres.
International immunology 2010;22(4):289-98.
2010: Sylvia Hartmann; Stefan Gesk; René Scholtysik; Markus Kreuz; Stefanie Bug; Inga Vater; Claudia Döring; Sergio Cogliatti; Marie Parrens; Jean-Philippe Merlio; Anna Kwiecinska; Anna Porwit; Pier Paolo Piccaluga; Stefano Pileri; Gerald Hoefler; Ralf Küppers; Reiner Siebert; Martin-Leo Hansmann
High resolution SNP array genomic profiling of peripheral T cell lymphomas, not otherwise specified, identifies a subgroup with chromosomal aberrations affecting the REL locus.
British journal of haematology 2010;148(3):402-12.
2010: Martin A Schumacher; Roland Schmitz; Verena Brune; Enrico Tiacci; Claudia Döring; Martin-Leo Hansmann; Reiner Siebert; Ralf Küppers
Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma.
Haematologica 2010;95(1):153-7.
2009: Marc Seifert; Ralf Küppers
Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation.
The Journal of experimental medicine 2009;206(12):2659-69.
2009: Anja Mottok; Christoph Renné; Marc Seifert; Elsie Oppermann; Wolf Bechstein; Martin-Leo Hansmann; Ralf Küppers; Andreas Bräuninger
Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities.
Blood 2009;114(20):4503-6.
2009: S Eckerle; V Brune; C Döring; Enrico Tiacci; V Bohle; Christer Sundström; R Kodet; Marco Paulli; B Falini; Wolfram Klapper; A B Chaubert; Klaus Willenbrock; D Metzler; Andreas Bräuninger; Ralf Küppers; Martin-Leo Hansmann
Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma.
Leukemia 2009;23(11):2129-38.
2009: Cornelius Courts; Anna Brunn; Manuel Montesinos-Rongen; Dörte Siemer; Volkmar Hans; Werner Paulus; Otmar D Wiestler; Ralf Küppers; Reiner Siebert; Martina Deckert
Preferential expression of truncated isoforms of FOXP1 in primary central nervous system lymphoma.
Journal of neuropathology and experimental neurology 2009;68(9):972-6.
2009: Roland Schmitz; Martin-Leo Hansmann; Verena Bohle; Jose Ignacio Martin-Subero; Sylvia Hartmann; Gunhild Mechtersheimer; Wolfram Klapper; Inga Vater; Maciej Giefing; Stefan Gesk; Jens Stanelle; Reiner Siebert; Ralf Küppers
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.
The Journal of experimental medicine 2009;206(5):981-9.
2009: Marc Seifert; Susanne A Steimle-Grauer; Tina Goossens; Martin-Leo Hansmann; Andreas Bräuninger; Ralf Küppers
A model for the development of human IgD-only B cells: Genotypic analyses suggest their generation in superantigen driven immune responses.
Molecular immunology 2009;46(4):630-9.
2009: Ralf Küppers
Molecular biology of Hodgkin lymphoma.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2009;():491-6.
2009: Roland Schmitz; Jens Stanelle; Martin-Leo Hansmann; Ralf Küppers
Pathogenesis of classical and lymphocyte-predominant Hodgkin lymphoma.
Annual review of pathology 2009;4():151-74.
2008: Natalia Szymanowska; Wolfram Klapper; Stefan Gesk; Ralf Küppers; José I Martín-Subero; Reiner Siebert
BCL2 and BCL3 are recurrent translocation partners of the IGH locus.
Cancer genetics and cytogenetics 2008;186(2):110-4.
2008: Verena Brune; Enrico Tiacci; Ines Pfeil; Claudia Döring; Susan Eckerle; Carel J M van Noesel; Wolfram Klapper; Brunangelo Falini; Anja von Heydebreck; Dirk Metzler; Andreas Bräuninger; Martin-Leo Hansmann; Ralf Küppers
Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis.
The Journal of experimental medicine 2008;205(10):2251-68.
2008: Maciej Giefing; Joachim Arnemann; Jose I Martin-Subero; Inga Nieländer; Stefanie Bug; Sylvia Hartmann; Norbert Arnold; Enrico Tiacci; Matthias Frank; Martin-Leo Hansmann; Ralf Küppers; Reiner Siebert
Identification of candidate tumour suppressor gene loci for Hodgkin and Reed-Sternberg cells by characterisation of homozygous deletions in classical Hodgkin lymphoma cell lines.
British journal of haematology 2008;142(6):916-24.
2008: Sylvia Hartmann; Jose I Martin-Subero; Stefan Gesk; Julia Hüsken; Maciej Giefing; Inga Nagel; Jennifer Riemke; Andreas Chott; Wolfram Klapper; Marie Parrens; Jean-Philippe Merlio; Ralf Küppers; Andreas Bräuninger; Reiner Siebert; Martin-Leo Hansmann
Detection of genomic imbalances in microdissected Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma by array-based comparative genomic hybridization.
Haematologica 2008;93(9):1318-26.
2008: Cornelius Courts; Manuel Montesinos-Rongen; Anna Brunn; Stefanie Bug; Dörte Siemer; Volkmar Hans; Ingmar Blümcke; Wolfram Klapper; Carlo Schaller; Otmar D Wiestler; Ralf Küppers; Reiner Siebert; Martina Deckert
Recurrent inactivation of the PRDM1 gene in primary central nervous system lymphoma.
Journal of neuropathology and experimental neurology 2008;67(7):720-7.
2008: Christoph Renné; Sarah Minner; Ralf Küppers; Martin-Leo Hansmann; Andreas Bräuninger
Autocrine NGFbeta/TRKA signalling is an important survival factor for Hodgkin lymphoma derived cell lines.
Leukemia research 2008;32(1):163-7.
2007: Ewerton Maggio; Daniel Benharroch; Jacob Gopas; Ulf Dittmer; Martin-Leo Hansmann; Ralf Küppers
Absence of measles virus genome and transcripts in Hodgkin-Reed/Sternberg cells of a cohort of Hodgkin lymphoma patients.
International journal of cancer. Journal international du cancer 2007;121(2):448-53.
2007: Ludger Sellmann; Stefan Gesk; Christoph Walter; Matthias Ritgen; Lana Harder; José I Martín-Subero; Roland Schroers; Dörte Siemer; Holger Nückel; Martin J S Dyer; Ulrich Dührsen; Reiner Siebert; Jan Dürig; Ralf Küppers
Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemia.
British journal of haematology 2007;138(2):217-20.
2007: José I Martín-Subero; Rachel E Ibbotson; Wolfram Klapper; L Michaux; Evelyne Callet-Bauchu; F Berger; María J Calasanz; C De Wolf-Peeters; Martin J S Dyer; Pascale Felman; Anne Gardiner; Randy D Gascoyne; Stefan Gesk; Lana Harder; D E Horsman; Michael Kneba; Ralf Küppers; A Majid; Nilima Parry-Jones; Matthias Ritgen; M Salido; F Solé; G Thiel; Hans-Heinrich Wacker; David Oscier; Iwona Wlodarska; Reiner Siebert
A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation.
Leukemia 2007;21(7):1532-44.
2007: Christoph Renné; Nora Hinsch; Klaus Willenbrock; Michael Fuchs; Wolfram Klapper; Andreas Engert; Ralf Küppers; Martin-Leo Hansmann; Andreas Bräuninger
The aberrant coexpression of several receptor tyrosine kinases is largely restricted to EBV-negative cases of classical Hodgkin's lymphoma.
International journal of cancer. Journal international du cancer 2007;120(11):2504-9.
2007: Christoph Renné; Klaus Willenbrock; Jose I Martin-Subero; Nora Hinsch; C Döring; Enrico Tiacci; Wolfram Klapper; P Möller; Ralf Küppers; Martin-Leo Hansmann; Reiner Siebert; Andreas Bräuninger
High expression of several tyrosine kinases and activation of the PI3K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma.
Leukemia 2007;21(4):780-7.
2007: Cornelius Courts; Manuel Montesinos-Rongen; Jose I Martin-Subero; Anna Brunn; Dörte Siemer; Reina Zühlke-Jenisch; Hendrik Pels; Annika Jürgens; Uwe Schlegel; Ingo G H Schmidt-Wolf; Carlo Schaller; Guido Reifenberger; Michael S Sabel; Ute Warnecke-Eberz; Otmar D Wiestler; Ralf Küppers; Reiner Siebert; Martina Deckert
Transcriptional profiling of the nuclear factor-kappaB pathway identifies a subgroup of primary lymphoma of the central nervous system with low BCL10 expression.
Journal of neuropathology and experimental neurology 2007;66(3):230-7.
2006: Ulrich H Frey; Holger Nückel; Ludger Sellmann; Dörte Siemer; Ralf Küppers; Jan Dürig; Ulrich Dührsen; Winfried Siffert
The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5686-92.
2006: Roland Schmitz; Roman K Thomas; Anne C Harttrampf; Claudia Wickenhauser; Joachim L Schultze; Martin-Leo Hansmann; Jürgen Wolf; Ralf Küppers
The major subtypes of human B-cell lymphomas lack mutations in BCL-2 family member BAD.
International journal of cancer. Journal international du cancer 2006;119(7):1738-40.
2006: Christoph Renné; Jose I Martin-Subero; Maren Eickernjäger; Martin-Leo Hansmann; Ralf Küppers; Reiner Siebert; Andreas Bräuninger
Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma.
The American journal of pathology 2006;169(2):655-64.
2006: Klaus Willenbrock; Ralf Küppers; Christoph Renné; Verena Brune; Susan Eckerle; Eckhart Weidmann; Andreas Bräuninger; Martin-Leo Hansmann
Common features and differences in the transcriptome of large cell anaplastic lymphoma and classical Hodgkin's lymphoma.
Haematologica 2006;91(5):596-604.
2006: Ralf Küppers; Andreas Bräuninger
Reprogramming of the tumour B-cell phenotype in Hodgkin lymphoma.
Trends in immunology 2006;27(5):203-5.
2006: Andreas Bräuninger; Roland Schmitz; Dörte Bechtel; Christoph Renné; Martin-Leo Hansmann; Ralf Küppers
Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma.
International journal of cancer. Journal international du cancer 2006;118(8):1853-61.
2006: Andreas Bräuninger; Christoph Renné; Klaus Willenbrock; Jose I Martin-Subero; Nora Hinsch; Enrico Tiacci; Reiner Siebert; Ralf Küppers; Martin-Leo Hansmann
[Global gene expression analysis and novel signalling pathways in Hodgkin lymphoma].
Verhandlungen der Deutschen Gesellschaft für Pathologie 2006;90():136-41.
2006: Ralf Küppers; Joachim Yahalom; Andreas Josting
Advances in biology, diagnostics, and treatment of Hodgkin's disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(1 Suppl 1):66-76.
2005: Dörte Bechtel; Julia Kurth; Claus Unkel; Ralf Küppers
Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas.
Blood 2005;106(13):4345-50.
2005: Klaus Willenbrock; Berit Jungnickel; Martin-Leo Hansmann; Ralf Küppers
Human splenic marginal zone B cells lack expression of activation-induced cytidine deaminase.
European journal of immunology 2005;35(10):3002-7.
2005: Ralf Küppers
Prognostic significance of Epstein-Barr virus-infected cells in the bone marrow of patients with nasal natural killer/T cell lymphoma.
Haematologica 2005;90(8):1011A.
2005: Roland Schmitz; Christoph Renné; Richard Rosenquist; Marianne Tinguely; Verena Distler; Fabio Menestrina; Maurizio Lestani; Tatjana Stankovic; Belinda Austen; Andreas Bräuninger; Martin-Leo Hansmann; Ralf Küppers
Insights into the multistep transformation process of lymphomas: IgH-associated translocations and tumor suppressor gene mutations in clonally related composite Hodgkin's and non-Hodgkin's lymphomas.
Leukemia 2005;19(8):1452-8.
2005: Ralf Küppers; Roland Schmitz; Verena Distler; Christoph Renné; Andreas Bräuninger; Martin-Leo Hansmann
Pathogenesis of Hodgkin's lymphoma.
European journal of haematology. Supplementum 2005;(66):26-33.
2005: Manuel Montesinos-Rongen; Roland Schmitz; Cornelius Courts; Werner Stenzel; Dörte Bechtel; Gerald Niedobitek; Ingmar Blümcke; Guido Reifenberger; Andreas von Deimling; Berit Jungnickel; Otmar D Wiestler; Ralf Küppers; Martina Deckert
Absence of immunoglobulin class switch in primary lymphomas of the central nervous system.
The American journal of pathology 2005;166(6):1773-9.
2005: R K Thomas; Roland Schmitz; A C Harttrampf; A Abdil-Hadi; Claudia Wickenhauser; Verena Distler; Martin-Leo Hansmann; Joachim L Schultze; Ralf Küppers; J Wolf
Apoptosis-resistant phenotype of classical Hodgkin's lymphoma is not mediated by somatic mutations within genes encoding members of the death-inducing signaling complex (DISC).
Leukemia 2005;19(6):1079-82.
2005: Christoph Renné; Klaus Willenbrock; Ralf Küppers; Martin-Leo Hansmann; Andreas Bräuninger
Autocrine- and paracrine-activated receptor tyrosine kinases in classic Hodgkin lymphoma.
Blood 2005;105(10):4051-9.
2005: Ralf Küppers
Mechanisms of B-cell lymphoma pathogenesis.
Nature reviews. Cancer 2005;5(4):251-62.
2005: Ralf Küppers; Martin-Leo Hansmann
The Hodgkin and Reed/Sternberg cell.
The international journal of biochemistry & cell biology 2005;37(3):511-7.
2004: Ralf Küppers
Prognosis in follicular lymphoma--it's in the microenvironment.
The New England journal of medicine 2004;351(21):2152-3.
2004: Richard Rosenquist; Göran Roos; Martin Erlanson; Ralf Küppers; Andreas Bräuninger; Martin-Leo Hansmann
Clonally related splenic marginal zone lymphoma and Hodgkin lymphoma with unmutated V gene rearrangements and a 15-yr time gap between diagnoses.
European journal of haematology 2004;73(3):210-4.
2004: Roman K Thomas; Claudia Wickenhauser; Samir Tawadros; Volker Diehl; Ralf Küppers; Jürgen Wolf; Roland Schmitz
Mutational analysis of the IkappaBalpha gene in activated B cell-like diffuse large B-cell lymphoma.
British journal of haematology 2004;126(1):50-4.
2004: Richard Rosenquist; Fabio Menestrina; Maurizio Lestani; Ralf Küppers; Martin-Leo Hansmann; Andreas Bräuninger
Indications for peripheral light-chain revision and somatic hypermutation without a functional B-cell receptor in precursors of a composite diffuse large B-cell and Hodgkin's lymphoma.
Laboratory investigation; a journal of technical methods and pathology 2004;84(2):253-62.
2003: Marianne Tinguely; Richard Rosenquist; Christer Sundström; Rose-Marie Amini; Ralf Küppers; Martin-Leo Hansmann; Andreas Bräuninger
Analysis of a clonally related mantle cell and Hodgkin lymphoma indicates Epstein-Barr virus infection of a Hodgkin/Reed-Sternberg cell precursor in a germinal center.
The American journal of surgical pathology 2003;27(11):1483-8.
2003: Ralf Küppers
B cells under influence: transformation of B cells by Epstein-Barr virus.
Nature reviews. Immunology 2003;3(10):801-12.
2003: Andreas Bräuninger; Tilmann Spieker; Anja Mottok; Audrey Sylvia Baur; Ralf Küppers; Martin-Leo Hansmann
Epstein-Barr virus (EBV)-positive lymphoproliferations in post-transplant patients show immunoglobulin V gene mutation patterns suggesting interference of EBV with normal B cell differentiation processes.
European journal of immunology 2003;33(6):1593-602.
2003: Julia Kurth; Martin-Leo Hansmann; Klaus Rajewsky; Ralf Küppers
Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4730-5.
2003: Ralf Küppers
Somatic hypermutation and B cell receptor selection in normal and transformed human B cells.
Annals of the New York Academy of Sciences 2003;987():173-9.
2003: Andreas Bräuninger; Hans-Heinrich Wacker; Klaus Rajewsky; Ralf Küppers; Martin-Leo Hansmann
Typing the histogenetic origin of the tumor cells of lymphocyte-rich classical Hodgkin's lymphoma in relation to tumor cells of classical and lymphocyte-predominance Hodgkin's lymphoma.
Cancer research 2003;63(7):1644-51.
2003: Ines Schwering; Andreas Bräuninger; Verena Distler; Julia Jesdinsky; Volker Diehl; Martin-Leo Hansmann; Klaus Rajewsky; Ralf Küppers
Profiling of Hodgkin's lymphoma cell line L1236 and germinal center B cells: identification of Hodgkin's lymphoma-specific genes.
Molecular medicine (Cambridge, Mass.) 2003;9(3-4):85-95.
2003: Ines Schwering; Andreas Bräuninger; Ulf Klein; Berit Jungnickel; Marianne Tinguely; Volker Diehl; Martin-Leo Hansmann; Riccardo Dalla-Favera; Klaus Rajewsky; Ralf Küppers
Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.
Blood 2003;101(4):1505-12.
2003: Ralf Küppers; Ulf Klein; Ines Schwering; Verena Distler; Andreas Bräuninger; Giorgio Cattoretti; Yuhai Tu; Gustavo Stolovitzky; Andrea Califano; Martin-Leo Hansmann; Riccardo Dalla-Favera
Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling.
The Journal of clinical investigation 2003;111(4):529-37.
2002: Julia Kurth; Andreas Perniok; Roland Schmitz; Christof Iking-Konert; Nicholas Chiorazzi; Keith M Thompson; Thomas Winkler; Klaus Rajewsky; Ralf Küppers
Lack of deleterious somatic mutations in the CD95 gene of plasmablasts from systemic lupus erythematosus patients and autoantibody-producing cell lines.
European journal of immunology 2002;32(12):3785-92.
2002: Niklas Feldhahn; Ines Schwering; Sanggyu Lee; Maria Wartenberg; Florian Klein; Hui Wang; Guolin Zhou; San Ming Wang; Janet D Rowley; Jürgen Hescheler; Martin Krönke; Klaus Rajewsky; Ralf Küppers; Markus Müschen
Silencing of B cell receptor signals in human naive B cells.
The Journal of experimental medicine 2002;196(10):1291-305.
2002: Ralf Küppers; Takashi Sonoki; E Satterwhite; Stefan Gesk; Lana Harder; DG Oscier; Philip W Tucker; Martin J S Dyer; Reiner Siebert
Lack of somatic hypermutation of IG V(H) genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene.
Leukemia 2002;16(5):937-9.
2002: Sabine Oeschger; Andreas Bräuninger; Ralf Küppers; Martin-Leo Hansmann
Tumor cell dissemination in follicular lymphoma.
Blood 2002;99(6):2192-8.
2002: Markus Müschen; Klaus Rajewsky; Martin Krönke; Ralf Küppers
The origin of CD95-gene mutations in B-cell lymphoma.
Trends in immunology 2002;23(2):75-80.
2002: Ralf Küppers; Ines Schwering; Andreas Bräuninger; Klaus Rajewsky; Martin-Leo Hansmann
Biology of Hodgkin's lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13 Suppl 1():11-8.
2002: Ralf Küppers
Molecular biology of Hodgkin's lymphoma.
Advances in cancer research 2002;84():277-312.
2001: T Goossens; Andreas Bräuninger; Ulf Klein; Ralf Küppers; Klaus Rajewsky
Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation.
European journal of immunology 2001;31(12):3638-48.
2001: Andreas Bräuninger; T Goossens; Klaus Rajewsky; Ralf Küppers
Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human.
European journal of immunology 2001;31(12):3631-7.
2001: Andreas Bräuninger; Tilmann Spieker; Klaus Willenbrock; Philippe Gaulard; Hans-Heinrich Wacker; Klaus Rajewsky; Martin-Leo Hansmann; Ralf Küppers
Survival and clonal expansion of mutating "forbidden" (immunoglobulin receptor-deficient) epstein-barr virus-infected b cells in angioimmunoblastic t cell lymphoma.
The Journal of experimental medicine 2001;194(7):927-40.
2001: Ralf Küppers; Riccardo Dalla-Favera
Mechanisms of chromosomal translocations in B cell lymphomas.
Oncogene 2001;20(40):5580-94.
2001: Laura Pasqualucci; Peter Neumeister; T Goossens; Gouri Nanjangud; Raju S K Chaganti; Ralf Küppers; Riccardo Dalla-Favera
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas.
Nature 2001;412(6844):341-6.
2001: Ralf Küppers; A B Sousa; Audrey Sylvia Baur; J G Strickler; Klaus Rajewsky; Martin-Leo Hansmann
Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin's disease and either follicular lymphoma or B-CLL.
Molecular medicine (Cambridge, Mass.) 2001;7(5):285-92.
2001: Klaus Willenbrock; Axel Roers; C Seidl; Hans-Heinrich Wacker; Ralf Küppers; Martin-Leo Hansmann
Analysis of T-cell subpopulations in T-cell non-Hodgkin's lymphoma of angioimmunoblastic lymphadenopathy with dysproteinemia type by single target gene amplification of T cell receptor- beta gene rearrangements.
The American journal of pathology 2001;158(5):1851-7.
2001: Markus Müschen; Ralf Küppers; Tilmann Spieker; Andreas Bräuninger; Klaus Rajewsky; Martin-Leo Hansmann
Molecular single-cell analysis of Hodgkin- and Reed-Sternberg cells harboring unmutated immunoglobulin variable region genes.
Laboratory investigation; a journal of technical methods and pathology 2001;81(3):289-95.
2001: Ralf Küppers; Andreas Bräuninger; Markus Müschen; Verena Distler; Martin-Leo Hansmann; Klaus Rajewsky
Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions.
Blood 2001;97(3):818-21.
2001: Andreas Bräuninger; W Yang; Hans-Heinrich Wacker; Klaus Rajewsky; Ralf Küppers; Martin-Leo Hansmann
B-cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease.
Blood 2001;97(3):714-9.
2000: Markus Müschen; Daniel Re; Berit Jungnickel; Volker Diehl; Klaus Rajewsky; Ralf Küppers
Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction.
The Journal of experimental medicine 2000;192(12):1833-40.
2000: Tilmann Spieker; Julia Kurth; Ralf Küppers; Klaus Rajewsky; Andreas Bräuninger; Martin-Leo Hansmann
Molecular single-cell analysis of the clonal relationship of small Epstein-Barr virus-infected cells and Epstein-Barr virus-harboring Hodgkin and Reed/Sternberg cells in Hodgkin disease.
Blood 2000;96(9):3133-8.
2000: Markus Müschen; Daniel Re; Andreas Bräuninger; Jürgen Wolf; Martin-Leo Hansmann; Volker Diehl; Ralf Küppers; Klaus Rajewsky
Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells.
Cancer research 2000;60(20):5640-3.
2000: Julia Kurth; Tilmann Spieker; Jochen Wustrow; G J Strickler; L M Hansmann; Klaus Rajewsky; Ralf Küppers
EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency.
Immunity 2000;13(4):485-95.
2000: Axel Roers; Martin-Leo Hansmann; Klaus Rajewsky; Ralf Küppers
Single-cell PCR analysis of T helper cells in human lymph node germinal centers.
The American journal of pathology 2000;156(3):1067-71.
2000: H Kanzler; Ralf Küppers; S Helmes; H H Wacker; A Chott; Martin-Leo Hansmann; Klaus Rajewsky
Hodgkin and Reed-Sternberg-like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell-derived clones: potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease.
Blood 2000;95(3):1023-31.
2000: Berit Jungnickel; Andrea Staratschek-Jox; Andreas Bräuninger; Tilmann Spieker; Jürgen Wolf; Volker Diehl; Martin-Leo Hansmann; Klaus Rajewsky; Ralf Küppers
Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma.
The Journal of experimental medicine 2000;191(2):395-402.
2000: Markus Müschen; Klaus Rajewsky; Andreas Bräuninger; Audrey Sylvia Baur; Joost Oudejans; Axel Roers; Martin-Leo Hansmann; Ralf Küppers
Rare occurrence of classical Hodgkin's disease as a T cell lymphoma.
The Journal of experimental medicine 2000;191(2):387-94.
1999: Manuel Montesinos-Rongen; Ralf Küppers; Dirk Schlüter; Tilmann Spieker; Dirk Van Roost; Carlo Schaller; Guido Reifenberger; Otmar D Wiestler; M Deckert-Schlüter
Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment.
The American journal of pathology 1999;155(6):2077-86.
1999: Ralf Küppers; Ulf Klein; Martin-Leo Hansmann; Klaus Rajewsky
Cellular origin of human B-cell lymphomas.
The New England journal of medicine 1999;341(20):1520-9.
1999: Manuel Montesinos-Rongen; Axel Roers; Ralf Küppers; Klaus Rajewsky; Martin-Leo Hansmann
Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease.
Blood 1999;94(5):1755-60.
1999: Ralf Küppers
Identifying the precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease: role of the germinal center in B-cell lymphomagenesis.
Journal of acquired immune deficiency syndromes (1999) 1999;21 Suppl 1():S74-9.
1999: A Jox; Thomas Zander; Ralf Küppers; Johannes Irsch; H Kanzler; Martin Kornacker; Heribert Bohlen; Volker Diehl; Jürgen Wolf
Somatic mutations within the untranslated regions of rearranged Ig genes in a case of classical Hodgkin's disease as a potential cause for the absence of Ig in the lymphoma cells.
Blood 1999;93(11):3964-72.
1999: Andreas Bräuninger; Martin-Leo Hansmann; JG Strickler; R Dummer; G Burg; Klaus Rajewsky; Ralf Küppers
Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma.
The New England journal of medicine 1999;340(16):1239-47.
1999: Andreas Bräuninger; Ralf Küppers; Tilmann Spieker; Reiner Siebert; JG Strickler; Brigitte Schlegelberger; Klaus Rajewsky; Martin-Leo Hansmann
Molecular analysis of single B cells from T-cell-rich B-cell lymphoma shows the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells.
Blood 1999;93(8):2679-87.
1999: Ralf Küppers; T Goossens; Ulf Klein
The role of somatic hypermutation in the generation of deletions and duplications in human Ig V region genes and chromosomal translocations.
Current topics in microbiology and immunology 1999;246():193-8.
1999: Ulf Klein; Klaus Rajewsky; Ralf Küppers
Phenotypic and molecular characterization of human peripheral blood B-cell subsets with special reference to N-region addition and J kappa-usage in V kappa J kappa-joints and kappa/lambda-ratios in naive versus memory B-cell subsets to identify traces of receptor editing processes.
Current topics in microbiology and immunology 1999;246():141-6; discussion 147.
1998: Ulf Klein; Klaus Rajewsky; Ralf Küppers
Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells.
The Journal of experimental medicine 1998;188(9):1679-89.
1998: Martina Vockerodt; M Soares; H Kanzler; Ralf Küppers; Martin Hafner; Martin-Leo Hansmann; Volker Diehl; Hans Tesch
Detection of clonal Hodgkin and Reed-Sternberg cells with identical somatically mutated and rearranged VH genes in different biopsies in relapsed Hodgkin's disease.
Blood 1998;92(8):2899-907.
1998: Laura Pasqualucci; Anna Migliazza; N Fracchiolla; Christopher M William; Antonino Neri; Luca Baldini; Raju S K Chaganti; Ulf Klein; Ralf Küppers; Klaus Rajewsky; Riccardo Dalla-Favera
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11816-21.
1998: M Fischer; Ralf Küppers
Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes.
European journal of immunology 1998;28(9):2971-7.
1998: Johannes Irsch; S Nitsch; Martin-Leo Hansmann; Klaus Rajewsky; Hans Tesch; Volker Diehl; A Jox; Ralf Küppers; Andreas Radbruch
Isolation of viable Hodgkin and Reed-Sternberg cells from Hodgkin disease tissues.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10117-22.
1998: Axel Roers; Manuel Montesinos-Rongen; Martin-Leo Hansmann; Klaus Rajewsky; Ralf Küppers
Amplification of TCRbeta gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal.
European journal of immunology 1998;28(8):2424-31.
1998: Ulf Klein; T Goossens; M Fischer; H Kanzler; A Braeuninger; Klaus Rajewsky; Ralf Küppers
Somatic hypermutation in normal and transformed human B cells.
Immunological reviews 1998;162():261-80.
1998: Ralf Küppers; Klaus Rajewsky; A Braeuninger; Martin-Leo Hansmann
L&H cells in lymphocyte-predominant Hodgkin's disease.
The New England journal of medicine 1998;338(11):763-4; author reply 764-5.
1998: T Goossens; Ulf Klein; Ralf Küppers
Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2463-8.
1998: A Jox; Thomas Zander; Martin Kornacker; H Kanzler; Ralf Küppers; Volker Diehl; Jürgen Wolf
Detection of identical Hodgkin-Reed Sternberg cell specific immunoglobulin gene rearrangements in a patient with Hodgkin's disease of mixed cellularity subtype at primary diagnosis and in relapse two and a half years later.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9(3):283-7.
1998: Ralf Küppers; Martin-Leo Hansmann; Klaus Rajewsky
Clonality and germinal centre B-cell derivation of Hodgkin/Reed-Sternberg cells in Hodgkin's disease.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9 Suppl 5():S17-20.
1998: Ralf Küppers; Klaus Rajewsky
The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease.
Annual review of immunology 1998;16():471-93.
1997: M Fischer; Ulf Klein; Ralf Küppers
Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation.
The Journal of clinical investigation 1997;100(7):1667-76.
1997: A Braeuninger; Ralf Küppers; JG Strickler; Hans-Heinrich Wacker; Klaus Rajewsky; Martin-Leo Hansmann
Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9337-42.
1997: Ralf Küppers; Klaus Rajewsky; Martin-Leo Hansmann
Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression.
European journal of immunology 1997;27(6):1398-405.
1997: Ulf Klein; Ralf Küppers; Klaus Rajewsky
Evidence for a large compartment of IgM-expressing memory B cells in humans.
Blood 1997;89(4):1288-98.
1997: Ralf Küppers; Axel Roers; H Kanzler
Molecular single cell studies of normal and transformed lymphocytes.
Cancer surveys 1997;30():45-58.
1997: Klaus Rajewsky; H Kanzler; Martin-Leo Hansmann; Ralf Küppers
Normal and malignant B-cell development with special reference to Hodgkin's disease.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1997;8 Suppl 2():79-81.
1996: H Kanzler; Ralf Küppers; Martin-Leo Hansmann; Klaus Rajewsky
Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.
The Journal of experimental medicine 1996;184(4):1495-505.
1996: Martin-Leo Hansmann; Ralf Küppers
Pathology and "molecular histology' of Hodgkin's disease and the border to non-Hodgkin's lymphomas.
Baillière's clinical haematology 1996;9(3):459-77.
1996: Ralf Küppers; M Hajadi; L Plank; Klaus Rajewsky; Martin-Leo Hansmann
Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human.
European journal of immunology 1996;26(8):1794-800.
1996: H Kanzler; Martin-Leo Hansmann; U Kapp; Jürgen Wolf; Volker Diehl; Klaus Rajewsky; Ralf Küppers
Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed-Sternberg cells of a Hodgkin's lymphoma patient.
Blood 1996;87(8):3429-36.
1996: Ralf Küppers; H Kanzler; Martin-Leo Hansmann; Klaus Rajewsky
Immunoglobulin V genes in Reed-Sternberg cells.
The New England journal of medicine 1996;334(6):404; author reply 405-6.
1996: Ralf Küppers; H Kanzler; Martin-Leo Hansmann; Klaus Rajewsky
Single cell analysis of Hodgkin/Reed-Sternberg cells.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1996;7 Suppl 4():27-30.
1995: Ralf Küppers; Klaus Rajewsky; M Zhao; G Simons; R Laumann; R Fischer; Martin-Leo Hansmann
Hodgkin's disease: clonal Ig gene rearrangements in Hodgkin and Reed-Sternberg cells picked from histological sections.
Annals of the New York Academy of Sciences 1995;764():523-4.
1995: Ulf Klein; Ralf Küppers; Klaus Rajewsky
Variable-region gene analysis of B-cell subsets derived from a 4-year-old child. Somatically mutated memory B cells accumulate in the peripheral blood already at young age.
Annals of the New York Academy of Sciences 1995;764():189-91.
1995: Ralf Küppers; K Willenbrock; Klaus Rajewsky; Martin-Leo Hansmann
Detection of clonal lambda light chain gene rearrangements in frozen and paraffin-embedded tissues by polymerase chain reaction.
The American journal of pathology 1995;147(3):806-14.
1995: Ulf Klein; G Klein; B Ehlin-Henriksson; Klaus Rajewsky; Ralf Küppers
Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes.
Molecular medicine (Cambridge, Mass.) 1995;1(5):495-505.
1995: Ralf Küppers; Martin-Leo Hansmann; Volker Diehl; Klaus Rajewsky
Molecular single-cell analysis of Hodgkin and Reed-Sternberg cells.
Molecular medicine today 1995;1(1):26-30.
1995: A Ehlich; Ralf Küppers
Analysis of immunoglobulin gene rearrangements in single B cells.
Current opinion in immunology 1995;7(2):281-4.
1995: Martin-Leo Hansmann; K Hell; Ralf Küppers
[Hodgkin cells are clonal B-cells in various stages of differentiation].
Der Pathologe 1995;16(2):88-93.
1994: Ralf Küppers; Klaus Rajewsky; M Zhao; G Simons; R Laumann; R Fischer; Martin-Leo Hansmann
Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10962-6.
1994: Ulf Klein; Ralf Küppers; Klaus Rajewsky
Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.
The Journal of experimental medicine 1994;180(4):1383-93.
1993: Ralf Küppers; M Zhao; Martin-Leo Hansmann; Klaus Rajewsky
Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.
The EMBO journal 1993;12(13):4955-67.
1993: Ulf Klein; Ralf Küppers; Klaus Rajewsky
Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life.
European journal of immunology 1993;23(12):3272-7.
1992: M Zhao; Ralf Küppers; Martin-Leo Hansmann; Johann Lorenzen; Klaus Rajewsky; R Fischer
[Detection of clonal immunoglobulin rearrangements in paraffin embedded tissues by PCR].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1992;76():243-7.