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Christian Kurbacher

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Procedures

Chemicals & Drugs

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Tumor Cells, Cultured

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Luminescent Measurements

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Publications

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Christian M Kurbacher; Cornelia Korn; Susanne Dexel; Ulrike Schween; Jutta A Kurbacher; Ralf Reichelt; Petra N Arenz
Isolation and culture of ovarian cancer cells and cell lines.
Louise A Knight; Christian M Kurbacher; Sharon Glaysher; Augusta Fernando; Ralf Reichelt; Susanne Dexel; Uwe Reinhold; Ian Cree
Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay.
Ian Cree; Christian M Kurbacher; Alan Lamont; andrew hindley; Sharon Love
A prospective randomized controlled trial of tumour chemosensitivity assay directed chemotherapy versus physician's choice in patients with recurrent platinum-resistant ovarian cancer.

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All Publications

2011: Christian M Kurbacher; Cornelia Korn; Susanne Dexel; Ulrike Schween; Jutta A Kurbacher; Ralf Reichelt; Petra N Arenz
Isolation and culture of ovarian cancer cells and cell lines.
Methods in molecular biology (Clifton, N.J.) 2011;731():161-80.
2009: Louise A Knight; Christian M Kurbacher; Sharon Glaysher; Augusta Fernando; Ralf Reichelt; Susanne Dexel; Uwe Reinhold; Ian Cree
Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay.
BMC cancer 2009;9():38.
2007: Ian Cree; Christian M Kurbacher; Alan Lamont; andrew hindley; Sharon Love
A prospective randomized controlled trial of tumour chemosensitivity assay directed chemotherapy versus physician's choice in patients with recurrent platinum-resistant ovarian cancer.
Anti-cancer drugs 2007;18(9):1093-101.
2007: M Hunz; Alexander Jetter; Mathias Warm; E Pantke; M Tuscher; Georg Hempel; Ulrich Jaehde; Michael Untch; Christian M Kurbacher; Uwe Fuhr
Plasma and tissue pharmacokinetics of epirubicin and Paclitaxel in patients receiving neoadjuvant chemotherapy for locally advanced primary breast cancer.
Clinical pharmacology and therapeutics 2007;81(5):659-68.
2006: Stephanie Hille; Daniel T Rein; Marion Riffelmann; Rainer Neumann; Judith Sartorius; Andreas Pfützner; Christian M Kurbacher; Thomas Schöndorf; Martina Breidenbach
Anticancer drugs induce mdr1 gene expression in recurrent ovarian cancer.
Anti-cancer drugs 2006;17(9):1041-4.
2005: Louise A Knight; Mark Conroy; Augusta Fernando; Marta Polak; Christian M Kurbacher; Ian Cree
Pilot studies of the effect of zoledronic acid (Zometa) on tumor-derived cells ex vivo in the ATP-based tumor chemosensitivity assay.
Anti-cancer drugs 2005;16(9):969-76.
2005: Ian Cree; Michael H Neale; Uwe Reinhold; Christian M Kurbacher
Treosulfan and gemcitabine.
Journal of cancer research and clinical oncology 2005;131(5):329-30; author reply 331.
2005: Christian M Kurbacher; Jutta A Kurbacher; Eva-Maria Cramer; Kerstin Rhiem; Peter K Mallman; Ralf Reichelt; Uwe Reinhold; Ursula Stier; Ian Cree
Continuous low-dose GM-CSF as salvage therapy in refractory recurrent breast or female genital tract carcinoma.
Oncology (Williston Park, N.Y.) 2005;19(4 Suppl 2):23-6.
2005: Christian M Kurbacher; Ian Cree
Chemosensitivity testing using microplate adenosine triphosphate-based luminescence measurements.
Methods in molecular medicine 2005;110():101-20.
2004: Thomas Schöndorf; Markus Hoopmann; Martina Breidenbach; Daniel T Rein; Uwe-Jochen Göhring; Martina Becker; Peter Mallmann; Christian M Kurbacher
Dysregulation of protein kinase C activity in chemoresistant metastatic breast cancer cells.
Anti-cancer drugs 2004;15(3):265-8.
2003: Markus Hoopmann; Markus M Valter; Christian M Kurbacher; Marc Possover; Peter Mallmann
Chemopersistent early recurrence in the perineal tear scar of an intrapartally diagnosed cervical cancer.
Gynecologic oncology 2003;91(1):272-4.
2003: Daniel T Rein; Martina Breidenbach; B Hönscheid; Ulrike Friebe-Hoffmann; Heike Engel; Uwe-Jochen Göhring; L Uekermann; Christian M Kurbacher; Thomas Schöndorf
Preeclamptic women are deficient of interleukin-10 as assessed by cytokine release of trophoblast cells in vitro.
Cytokine 2003;23(4-5):119-25.
2003: Sanjay Sharma; Michael H Neale; Federica Di Nicolantonio; Louise A Knight; Pauline A Whitehouse; Stuart J Mercer; Bernard R Higgins; Alan Lamont; Richard Osborne; andrew hindley; Christian M Kurbacher; Ian Cree
Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma.
BMC cancer 2003;3():19.
2003: Martina Breidenbach; Daniel T Rein; Thomas Schöndorf; Torsten Schmidt; Ellen König; Markus M Valter; Christian M Kurbacher
Hematological side-effect profiles of individualized chemotherapy regimen for recurrent ovarian cancer.
Anti-cancer drugs 2003;14(5):341-6.
2003: Christian M Kurbacher; Ottilia M Grecu; Ursula Stier; Tobias J Gilster; Margit-M Janát; Michael Untch; Gottfried E Konecny; Howard W Bruckner; Ian Cree
ATP chemosensitivity testing in ovarian and breast cancer: early clinical trials.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;161():221-30.
2003: Michael Untch; Nina Ditsch; E Langer; Christian M Kurbacher; C Crohns; Gottfried E Konecny; Steffen Kahlert; Ingo Bauerfeind; Hermann Hepp
Chemosensitivity testing in gynecologic oncology--dream or reality?
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;161():146-58.
2003: Thomas Schöndorf; Rainer Neumann; Carolin Benz; Martina Becker; Marion Riffelmann; Uwe-Jochen Göhring; Judith Sartorius; Carl-Heinz Wirsing von König; Martina Breidenbach; Markus M Valter; Markus Hoopmann; Federica Di Nicolantonio; Christian M Kurbacher
Cisplatin, doxorubicin and paclitaxel induce mdr1 gene transcription in ovarian cancer cell lines.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2003;161():111-6.
2002: Daniel T Rein; Christian M Kurbacher; Martina Breidenbach; Thomas Schöndorf; Torsten Schmidt; Ellen König; Uwe-Jochen Göhring; Jens-Uwe Blohmer; Peter Mallmann
Weekly carboplatin and docetaxel for locally advanced primary and recurrent cervical cancer: a phase I study.
Gynecologic oncology 2002;87(1):98-103.
2002: Ellen König; Christian M Kurbacher; Martin Schwonzen; Martina Breidenbach; Peter Mallmann
A phase II study of dose-dense docetaxel and mitoxantrone in the treatment of patients with high-risk metastatic breast cancer.
Anti-cancer drugs 2002;13(8):827-32.
2002: Christian M Kurbacher; Jutta A Kurbacher; Ian Cree; Eva Wardelmann; Ursula Stier; Hannelore Kolhagen; Anton Scharl; Peter E Andreotti
Chemosensitivity of normal human trophoblasts evaluated by a newly developed ATP-based luminescence assay.
Anti-cancer drugs 2002;13(7):701-8.
2002: Thomas Schöndorf; Christian M Kurbacher; Uwe-Jochen Göhring; Carolin Benz; Martina Becker; Judith Sartorius; Hannelore Kolhagen; Peter Mallman; Rainer Neumann
Induction of MDR1-gene expression by antineoplastic agents in ovarian cancer cell lines.
Anticancer research 2002;22(4):2199-203.
2002: Federica Di Nicolantonio; Michael H Neale; Louise A Knight; Alan Lamont; Geraldine E Skailes; Richard J Osborne; Rosanne Allerton; Christian M Kurbacher; Ian Cree
Use of an ATP-based chemosensitivity assay to design new combinations of high-concentration doxorubicin with other drugs for recurrent ovarian cancer.
Anti-cancer drugs 2002;13(6):625-30.
2002: Daniel T Rein; Thomas Schondorf; Uwe-Jochen Gohring; Christian M Kurbacher; Irma Pinto; Martina Breidenbach; Peter Mallmann; Hannelore Kolhagen; Heike Engel
Cytokine expression in peripheral blood lymphocytes indicates a switch to T(HELPER) cells in patients with preeclampsia.
Journal of reproductive immunology 2002;54(1-2):133-42.
2002: Martina Breidenbach; Daniel T Rein; Peter Mallmann; Christian M Kurbacher
Individualized long-term chemotherapy for recurrent ovarian cancer after failing high-dose treatment.
Anti-cancer drugs 2002;13(2):173-6.
2001: Michael H Neale; NE Myatt; G G Khoury; P Weaver; Alan Lamont; John L Hungerford; Christian M Kurbacher; P Hall; Pippa G Corrie; Ian Cree
Comparison of the ex vivo chemosensitivity of uveal and cutaneous melanoma.
Melanoma research 2001;11(6):601-9.
2001: Thomas Schöndorf; Martina Becker; Uwe-Jochen Göhring; Barbara Wappenschmidt; Hannelore Kolhagen; Christian M Kurbacher
Interaction of cisplatin, paclitaxel and adriamycin with the tumor suppressor PTEN.
Anti-cancer drugs 2001;12(10):797-800.
2001: Daniel T Rein; Christian M Kurbacher
The role of chemotherapy in invasive cancer of the cervix uteri: current standards and future prospects.
Anti-cancer drugs 2001;12(10):787-95.
2001: T Schmidt; Daniel T Rein; Dolores Foth; H W Eibach; Christian M Kurbacher; Peter Mallmann; Thomas Römer
Prognostic value of repeated serum CA 125 measurements in first trimester pregnancy.
European journal of obstetrics, gynecology, and reproductive biology 2001;97(2):168-73.
2001: Thomas Schöndorf; Christian M Kurbacher; Martina Becker; Mathias Warm; Hannelore Kolhagen; Uwe-Jochen Göhring
Heterogeneity of proteinkinase C activity and PKC-zeta expression in clinical breast carcinomas.
Clinical and experimental medicine 2001;1(1):1-8.
2001: P Boabang; Christian M Kurbacher; A Waida; BK Amo-Takyi
Detection of aberrations of chromosome 17 and p53 gene expression and their correlation to histologic grading and prognosis in primary invasive squamous cell carcinoma of the cervix.
Gynecologic and obstetric investigation 2001;51(4):233-9.
2000: Thomas Schöndorf; Martina Becker; Hannelore Kolhagen; Christian M Kurbacher; Uwe-Jochen Göhring
Ex vivo assays to evaluate the role of protein kinase C in tumor cells of patients with breast cancer.
Anticancer research 2000;20(6D):5073-6.
2000: Daniel T Rein; Thomas Schöndorf; Martina Breidenbach; M M Janát; A Weikelt; Uwe-Jochen Göhring; Martina Becker; Peter Mallmann; Christian M Kurbacher
Lack of correlation between P53 expression, BCL-2 expression, apoptosis and ex vivo chemosensitivity in advanced human breast cancer.
Anticancer research 2000;20(6D):5069-72.
2000: Michael H Neale; Alan Lamont; andrew hindley; Christian M Kurbacher; Ian Cree
The ex vivo effect of high concentrations of doxorubicin on recurrent ovarian carcinoma.
Anti-cancer drugs 2000;11(10):865-71.
2000: P Boabang; Christian M Kurbacher; H Kohlhagen; A Waida; BK Amo-Takyi
Anti-neoplastic activity of topotecan versus cisplatin, etoposide and paclitaxel in four squamous cell cancer cell lines of the female genital tract using an ATP-Tumor Chemosensitivity Assay.
Anti-cancer drugs 2000;11(10):843-8.
2000: Martin Schwonzen; Christian M Kurbacher; Peter Mallmann
Liposomal doxorubicin and weekly paclitaxel in the treatment of metastatic breast cancer.
Anti-cancer drugs 2000;11(9):681-5.
2000: Gottfried E Konecny; C Crohns; Mark D Pegram; Margret Felber; S Lude; Christian M Kurbacher; Ian Cree; Hermann Hepp; Michael Untch
Correlation of drug response with the ATP tumorchemosensitivity assay in primary FIGO stage III ovarian cancer.
Gynecologic oncology 2000;77(2):258-63.
2000: Martina Breidenbach; Daniel T Rein; Torsten Schmidt; Walter Heindel; Hannelore Kolhagen; Peter Mallmann; Christian M Kurbacher
Intra-arterial mitoxantrone and paclitaxel in a patient with Stewart-Treves syndrome: selection of chemotherapy by an ex vivo ATP-based chemosensitivity assay.
Anti-cancer drugs 2000;11(4):269-73.
1999: Thomas Schöndorf; Anton Scharl; Christian M Kurbacher; O Bien; Martina Becker; Rainer Neumann; Hannelore Kolhagen; J Rustemeyer; Peter Mallmann; Uwe-Jochen Göhring
Amplification of the mdr1-gene is uncommon in recurrent ovarian carcinomas.
Cancer letters 1999;146(2):195-9.
1999: Uwe-Jochen Göhring; Thomas Schöndorf; V R Kiecker; Martina Becker; Christian M Kurbacher; Anton Scharl
Immunohistochemical detection of H-ras protooncoprotein p21 indicates favorable prognosis in node-negative breast cancer patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1999;20(4):173-83.
1999: Ian Cree; Michael H Neale; NE Myatt; P G de Takats; P Hall; J Grant; Christian M Kurbacher; Uwe Reinhold; Karsten Neuber; R M MacKie; J Chana; P C Weaver; G G Khoury; C Sartori; Peter E Andreotti
Heterogeneity of chemosensitivity of metastatic cutaneous melanoma.
Anti-cancer drugs 1999;10(5):437-44.
1999: Ian Cree; Christian M Kurbacher
ATP-based tumor chemosensitivity testing: assisting new agent development.
Anti-cancer drugs 1999;10(5):431-5.
1999: Heike Engel; E Kaya; Rainer Bald; Hannelore Kolhagen; Ottilia M Grecu; Thomas Schöndorf; U Brenne; Christian M Kurbacher; Uwe-Jochen Göhring; M Kleine; Peter Mallmann
Fetal cord blood as an alternative source of hematopoietic progenitor cells: immunophenotype, maternal cell contamination, and ex vivo expansion.
Journal of hematotherapy 1999;8(2):141-55.
1999: Michael H Neale; NE Myatt; Ian Cree; Christian M Kurbacher; Alexander Foss; John L Hungerford; P N Plowman
Combination chemotherapy for choroidal melanoma: ex vivo sensitivity to treosulfan with gemcitabine or cytosine arabinoside.
British journal of cancer 1999;79(9-10):1487-93.
1998: Heike Engel; J Friedrich; C Kleespies; Christian M Kurbacher; Thomas Schöndorf; Ottilia M Grecu; Hannelore Kolhagen; Peter Mallmann
Detection of chromosomal aberrations in tumor cells and tumor infiltrating lymphocytes by molecular cytogenetics in patients with gynecological cancer.
Cancer genetics and cytogenetics 1998;106(2):159-65.
1998: Christian M Kurbacher; Peter Mallmann
Chemoprotection in anticancer therapy: the emerging role of amifostine (WR-2721).
Anticancer research 1998;18(3C):2203-10.
1998: Thomas Schöndorf; Heike Engel; Christian M Kurbacher; U Brenne; Hannelore Kolhagen; Uwe-Jochen Göhring; Anton Scharl; Peter Mallmann
Immunologic features of tumor-infiltrating lymphocytes and peripheral blood lymphocytes in ovarian cancer patients.
Journal of the Society for Gynecologic Investigation 1998;5(2):102-7.
1998: Christian M Kurbacher; Ian Cree; Howard W Bruckner; U Brenne; Jutta A Kurbacher; K Müller; T Ackermann; T J Gilster; Lucas Wilhelm; Heike Engel; Peter Mallmann; Peter E Andreotti
Use of an ex vivo ATP luminescence assay to direct chemotherapy for recurrent ovarian cancer.
Anti-cancer drugs 1998;9(1):51-7.
1997: Christian M Kurbacher; Howard W Bruckner; Ian Cree; Jutta A Kurbacher; Lucas Wilhelm; G Pöch; D Indefrei; Peter Mallmann; Peter E Andreotti
Mitoxantrone combined with paclitaxel as salvage therapy for platinum-refractory ovarian cancer: laboratory study and clinical pilot trial.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(9):1527-33.
1997: NE Myatt; Ian Cree; Christian M Kurbacher; Alexander Foss; John L Hungerford; P N Plowman
The ex vivo chemosensitivity profile of choroidal melanoma.
Anti-cancer drugs 1997;8(8):756-62.
1997: Ian Cree; Christian M Kurbacher
Individualizing chemotherapy for solid tumors--is there any alternative?
Anti-cancer drugs 1997;8(6):541-8.
1996: Ian Cree; R D Petty; Christian M Kurbacher; M Untch
Tumor chemosensitivity and chemoresistance assays.
Cancer 1996;78(9):2031-2.
1996: Ian Cree; Christian M Kurbacher; M Untch; L A Sutherland; E M Hunter; A M Subedi; E A James; J A Dewar; P E Preece; Peter E Andreotti; H W Bruckner
Correlation of the clinical response to chemotherapy in breast cancer with ex vivo chemosensitivity.
Anti-cancer drugs 1996;7(6):630-5.
1996: Christian M Kurbacher; U Wagner; B Kolster; Peter E Andreotti; Dieter Krebs; H W Bruckner
Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro.
Cancer letters 1996;103(2):183-9.
1996: Christian M Kurbacher; Peter Mallmann; Jutta A Kurbacher; H Hübner; Dieter Krebs
-Chemosensitivity testing in gynecologic oncology. Experiences with an ATP bioluminescence assay-.
Geburtshilfe und Frauenheilkunde 1996;56(2):70-8.
1996: Christian M Kurbacher; Ian Cree; U Brenne; H W Bruckner; Jutta A Kurbacher; Peter Mallmann; Peter E Andreotti; Dieter Krebs
Heterogeneity of in vitro chemosensitivity in perioperative breast cancer cells to mitoxantrone versus doxorubicin evaluated by a microplate ATP bioluminescence assay.
Breast cancer research and treatment 1996;41(2):161-70.
1996: Christian M Kurbacher; U Brenne; Jutta A Kurbacher; Peter Mallmann; Dieter Krebs
[Comparison of the cytostatic effect of epirubicin and mitoxantrone on native breast carcinoma cells using the ATP tumor chemosensitivity assay].
Zentralblatt für Gynäkologie 1996;118(5):271-8.
1995: Peter E Andreotti; Ian Cree; Christian M Kurbacher; D M Hartmann; D Linder; G Harel; I Gleiberman; P A Caruso; S H Ricks; M Untch
Chemosensitivity testing of human tumors using a microplate adenosine triphosphate luminescence assay: clinical correlation for cisplatin resistance of ovarian carcinoma.
Cancer research 1995;55(22):5276-82.
1995: Christian M Kurbacher; H W Bruckner; Peter E Andreotti; Jutta A Kurbacher; G Sass; Dieter Krebs
In vitro activity of titanocenedichloride versus cisplatin in four ovarian carcinoma cell lines evaluated by a microtiter plate ATP bioluminescence assay.
Anti-cancer drugs 1995;6(5):697-704.
1995: Christian M Kurbacher; Wolfram Jäger; Jutta A Kurbacher; A Bittl; Ludwig Wildt; N Lang
Influence of human luteinizing hormone on cell growth and CA 125 secretion of primary epithelial ovarian carcinomas in vitro.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1995;16(6):374-84.
1994: O Rieker; F Grünwald; Günter Layer; Christian M Kurbacher; A L Hotze; Christian Menzel; Hans-Jürgen Biersack
Disseminated bone marrow metastases from primary breast cancer: detection and follow-up by radioimmune bone marrow scintigraphy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(9):1485-7.
1994: Christian M Kurbacher; Peter Mallmann; Jutta A Kurbacher; G Sass; Peter E Andreotti; A Rahmun; H Hübner; Dieter Krebs
In vitro activity of titanocenedichloride versus cisplatin and doxorubicin in primary and recurrent epithelial ovarian cancer.
Anticancer research 1994;14(5A):1961-5.
1994: Christian M Kurbacher; W Nagel; Peter Mallmann; Jutta A Kurbacher; G Sass; H Hübner; Peter E Andreotti; Dieter Krebs
In vitro activity of titanocenedichloride in human renal cell carcinoma compared to conventional antineoplastic agents.
Anticancer research 1994;14(4A):1529-33.
1988: A Werner; O Bellmann; J Vogel; Christian M Kurbacher; W Nagel; Klaus Diedrich; Dieter Krebs
[Immunocytochemical detection of the estrogen receptor and lectin binding sites in tumor cell colonies growing in vitro].
Geburtshilfe und Frauenheilkunde 1988;48(5):299-304.