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Makoto Kuro-o

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TOP 3
Ming Chang Hu; Makoto Kuro-o; Orson W Moe
Renal and extrarenal actions of Klotho.
Jakob Voelkl; Mohamed S E Ahmed; Ioana Alesutan; Martina Feger; Volker Kuhn; Makoto Kuro-o; Christina B Leibrock; Sobuj Mia; Leticia Quintanilla-Martinez; Kevin P Rosenblatt; Florian Lang
Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice.
Ci-Di Chen; Alpaslan Dedeoglu; Eustathia L Giannaris; Jason D Hinman; Makoto Kuro-o; Hu Li; Jennifer I Luebke; Douglas Rosene; JA Sloane; Ella Zeldich; Nurgul Aytan; Rashmi Bansal; Carmela Abraham
The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.

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All Publications

2013: Ming Chang Hu; Makoto Kuro-o; Orson W Moe
Renal and extrarenal actions of Klotho.
Seminars in nephrology 2013;33(2):118-29.
2013: Jakob Voelkl; Mohamed S E Ahmed; Ioana Alesutan; Martina Feger; Volker Kuhn; Makoto Kuro-o; Christina B Leibrock; Sobuj Mia; Leticia Quintanilla-Martinez; Kevin P Rosenblatt; Florian Lang
Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice.
The Journal of clinical investigation 2013;123(2):812-22.
2013: Ci-Di Chen; Alpaslan Dedeoglu; Eustathia L Giannaris; Jason D Hinman; Makoto Kuro-o; Hu Li; Jennifer I Luebke; Douglas Rosene; JA Sloane; Ella Zeldich; Nurgul Aytan; Rashmi Bansal; Carmela Abraham
The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(5):1927-39.
2013: Tso-Hsiao Chen; Yen-Cheng Chen; Makoto Kuro-o; Yuh-Mou Sue; Ho-Han Wu; Cheng-Hsien Chen; Chung-Yi Cheng
The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice.
European journal of pharmacology 2013;698(1-3):67-73.
2013: Zhong-Jian Shen; Kazuhiro Shiizaki; Johanne Pastor; Aktar Ali; Robert D Blank; Jie Hu; Makoto Kuro-o; James S Malter
Pin1 Null Mice Exhibit Low Bone Mass and Attenuation of BMP Signaling.
PloS one 2013;8(5):e63565.
2013: Ming Chang Hu; Makoto Kuro-o; Orson W Moe
Klotho and chronic kidney disease.
Contributions to nephrology 2013;180():47-63.
2013: Ming Chang Hu; Makoto Kuro-o; Kazuhiro Shiizaki; Orson W Moe
Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism.
Annual review of physiology 2013;75():503-33.
2012: Wei Ling Lau; Elizabeth M Leaf; Orson W Moe; Marc M Takeno; Ming Chang Hu; Makoto Kuro-o; Cecilia M Giachelli
Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet.
Kidney international 2012;82(12):1261-70.
2012: Masahiro Azuma; Yusuke Furukawa; Jiro Kikuchi; Daisuke Koyama; Makoto Kuro-o; Kazuhiro Shiizaki; Dissayabutra Thasinas; Hiromichi Yoshizawa; Eiji Kusano
Promoter methylation confers kidney-specific expression of the Klotho gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(10):4264-74.
2012: Regina Goetz; Serkan Kir; Makoto Kuro-o; Hiroshi Kurosu; Jinghong Ma; Mutsuko Ohnishi; Johanne Pastor; Mohammed S Razzaque; Lei Wang; Weiming Gai; Moosa Mohammadi
Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor.
The Journal of biological chemistry 2012;287(34):29134-46.
2012: Ming Chang Hu; Makoto Kuro-o; Orson W Moe
The emerging role of Klotho in clinical nephrology.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27(7):2650-7.
2012: Makoto Kuro-o
Klotho in health and disease.
Current opinion in nephrology and hypertension 2012;21(4):362-8.
2012: Dwight C German; Ida Khobahy; Makoto Kuro-o; Johanne Pastor; Xinran Liu
Nuclear localization of Klotho in brain: an anti-aging protein.
Neurobiology of aging 2012;33(7):1483.e25-30.
2012: Tetsu Akimoto; Chiharu Ito; Yoshitaka Iwazu; Makoto Kuro-o; Takuya Miki; Shigeaki Muto; Akihiko Numata; Naoko Otani; Johanne V Pastor; Osamu Saito; Kazuhiro Shiizaki; Taro Sugase; Eri Takeshima; Yuko Watanabe; Tomoyuki Yamazaki; Hiromichi Yoshizawa; Eiji Kusano
The relationship between the soluble Klotho protein and the residual renal function among peritoneal dialysis patients.
Clinical and experimental nephrology 2012;16(3):442-7.
2012: Yuhong Wang; Makoto Kuro-o; Zhongjie Sun
Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway.
Aging cell 2012;11(3):410-7.
2012: Hidekazu Sugiura; Takumi Yoshida; Junko Kohei; Makoto Kuro-o; Hiroshi Kurosu; Michihiro Mitobe; Kosaku Nitta; Shunji Shiohira; Ken Tsuchiya
Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis.
American journal of physiology. Renal physiology 2012;302(10):F1252-64.
2012: Regina Goetz; Makoto Kuro-o; Hiroshi Kurosu; Jinghong Ma; Mutsuko Ohnishi; Nelly Pitteloud; Mohammed S Razzaque; Yisrael Sidis; Lei Wang; Junko Akiyoshi; Xunshan Ding; Weiming Gai; Moosa Mohammadi
Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands.
Molecular and cellular biology 2012;32(10):1944-54.
2012: Jian Xie; Makoto Kuro-o; Sung-Wan An; Lutz Birnbaumer; Seung-Kuy Cha; Chou-Long Huang
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart.
Nature communications 2012;3():1238.
2012: Tetsu Akimoto; Yasuhiro Ando; Chiharu Ito; Kana Iwazu; Takanori Komada; Makoto Kuro-o; Yoshiyuki Morishita; Shigeaki Muto; Akihiko Numata; Naoko Otani; Kazuhiro Shiizaki; Eri Takeshima; Yuko Watanabe; Tomoyuki Yamazaki; Hiromichi Yoshizawa; Eiji Kusano
Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease.
BMC nephrology 2012;13():155.
2012: Afsaneh Rangiani; Anika Rodgers; Yao Sun; Baozhi Yuan; Tian Gao; Makoto Kuro-o; Yongbo Lu; Chunlin Qin; Zhengguo Cao; Jian Q Feng
Protective roles of DMP1 in high phosphate homeostasis.
PloS one 2012;7(8):e42329.
2012: Ming Chang Hu; Makoto Kuro-o; Orson W Moe
Secreted klotho and chronic kidney disease.
Advances in experimental medicine and biology 2012;728():126-57.
2012: Makoto Kuro-o
Klotho and βKlotho.
Advances in experimental medicine and biology 2012;728():25-40.
2011: D T Asuzu; M R Bardsley; Gianrico Farrugia; Y Hayashi; Ferenc Izbeki; Makoto Kuro-o; David R Linden; A Lorincz; L N Popko; D L Young; T Ordog
Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2011;23(7):e309-23.
2011: George B John; Chung-Yi Cheng; Makoto Kuro-o
Role of Klotho in aging, phosphate metabolism, and CKD.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2011;58(1):127-34.
2011: Mentor Sopjani; Ana Velic; Christine Zelenak; Carlos Munoz; Kevin P Rosenblatt; Ioana Alesutan; Miribane Dërmaku-Sopjani; Michael Föller; Shuchen Gu; Makoto Kuro-o; Florian Lang
Regulation of the Na+/K+ ATPase by Klotho.
FEBS letters 2011;585(12):1759-64.
2011: Makoto Kuro-o
Klotho and the aging process.
The Korean journal of internal medicine 2011;26(2):113-22.
2011: Makoto Kuro-o
Phosphate and Klotho.
Kidney international. Supplement 2011;(121):S20-3.
2011: Shigehiro Doi; Yonglong Zou; Osamu Togao; Johanne V Pastor; George B John; Lei Wang; Kazuhiro Shiizaki; Russell Gotschall; Susan Schiavi; Noriaki Yorioka; Masaya Takahashi; David A Boothman; Makoto Kuro-o
Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice.
The Journal of biological chemistry 2011;286(10):8655-65.
2011: Chung-Yi Cheng; Makoto Kuro-o; Mohammed S Razzaque
Molecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho system.
Advances in chronic kidney disease 2011;18(2):91-7.
2011: Hye Eun Yoon; Jung Yeon Ghee; ShangGuo Piao; Ji-Hyun Song; Dong He Han; Sol Kim; Naro Ohashi; Hiroyuki Kobori; Makoto Kuro-o; Chul Woo Yang
Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011;26(3):800-13.
2011: Xiaoyu Wang; Yonglong Zou; David A Boothman; Ying Dong; Amyn A Habib; Ameena J Jiwani; Makoto Kuro-o; Johanne Pastor; Minzi Ruan; Chin-Rang Yang
Improved protein arrays for quantitative systems analysis of the dynamics of signaling pathway interactions.
Proteome science 2011;9():53.
2011: Ming Chang Hu; Mingjun Shi; Jianning Zhang; Henry Quiñones; Carolyn Griffith; Makoto Kuro-o; Orson W Moe
Klotho deficiency causes vascular calcification in chronic kidney disease.
Journal of the American Society of Nephrology : JASN 2011;22(1):124-36.
2010: Ming-Chang Hu; Mingjun Shi; Jianning Zhang; Herson I Quiñones; Makoto Kuro-o; Orson W Moe
Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective.
Kidney international 2010;78(12):1240-51.
2010: Hiroshi Iwata; Ichiro Manabe; Katsuhito Fujiu; Tetsufumi Yamamoto; Norifumi Takeda; Kosei Eguchi; Akiko Furuya; Makoto Kuro-o; Masataka Sata; Ryozo Nagai
Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages.
Circulation 2010;122(20):2048-57.
2010: Ming-Chang Hu; Makoto Kuro-o; Orson W Moe
Klotho and kidney disease.
Journal of nephrology 2010;23 Suppl 16():S136-44.
2010: Stephanie S Fischer; Daniela S Kempe; Christina B Leibrock; Rexhep Rexhepaj; Balasaheb Siraskar; Krishna M Boini; Teresa F Ackermann; Michael Föller; Berthold Hocher; Kevin P Rosenblatt; Makoto Kuro-o; Florian Lang
Hyperaldosteronism in Klotho-deficient mice.
American journal of physiology. Renal physiology 2010;299(5):F1171-7.
2010: Klementina Fon Tacer; Angie L Bookout; Xunshan Ding; Hiroshi Kurosu; George B John; Lei Wang; Regina Goetz; Moosa Mohammadi; Makoto Kuro-o; David J Mangelsdorf; Steven A Kliewer
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.
Molecular endocrinology (Baltimore, Md.) 2010;24(10):2050-64.
2010: Ching-Chyuan Hsieh; Makoto Kuro-o; Kevin P Rosenblatt; Reynolds Brobey; John Papaconstantinou
The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging.
Aging 2010;2(9):597-611.
2010: Ming Chang Hu; Mingjun Shi; Jianning Zhang; Johanne Pastor; Teruyo Nakatani; Beate Lanske; Mohammed S Razzaque; Kevin P Rosenblatt; Michel G Baum; Makoto Kuro-o; Orson W Moe
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(9):3438-50.
2010: Ferenc Izbeki; David T Asuzu; Andrea Lorincz; Michael R Bardsley; Laura N Popko; Kyoung Moo Choi; David L Young; Yujiro Hayashi; David R Linden; Makoto Kuro-o; Gianrico Farrugia; Tamas Ordog
Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice.
The Journal of physiology 2010;588(Pt 16):3101-17.
2010: Masaya Takahashi; Osamu Togao; Makoto Obara; Marc Van Cauteren; Yoshiharu Ohno; Shigehiro Doi; Makoto Kuro-o; Craig R Malloy; Connie C Hsia; Ivan Dimitrov
Ultra-short echo time (UTE) MR imaging of the lung: comparison between normal and emphysematous lungs in mutant mice.
Journal of magnetic resonance imaging : JMRI 2010;32(2):326-33.
2010: Osamu Togao; Shigehiro Doi; Makoto Kuro-o; Takao Masaki; Noriaki Yorioka; Masaya Takahashi
Assessment of renal fibrosis with diffusion-weighted MR imaging: study with murine model of unilateral ureteral obstruction.
Radiology 2010;255(3):772-80.
2010: Makoto Kuro-o
A potential link between phosphate and aging--lessons from Klotho-deficient mice.
Mechanisms of ageing and development 2010;131(4):270-5.
2010: Makoto Kuro-o
Overview of the FGF23-Klotho axis.
Pediatric nephrology (Berlin, Germany) 2010;25(4):583-90.
2010: Regina Goetz; Yuji Nakada; Ming Chang Hu; Hiroshi Kurosu; Lei Wang; Teruyo Nakatani; Mingjun Shi; Anna V Eliseenkova; Mohammed S Razzaque; Orson W Moe; Makoto Kuro-o; Moosa Mohammadi
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):407-12.
2010: Makoto Kuro-o
Klotho.
Pflügers Archiv : European journal of physiology 2010;459(2):333-43.
2009: David J Friedman; Maryam Afkarian; Hector Tamez; Ishir Bhan; Tamara Isakova; Myles Wolf; Elizabeth Ankers; Jun Ye; Marcello Tonelli; Carmine Zoccali; Makoto Kuro-o; Orson Moe; S Ananth Karumanchi; Ravi Thadhani
Klotho variants and chronic hemodialysis mortality.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(11):1847-55.
2009: Laura Bloch; Olga Sineshchekova; Daniela Reichenbach; Karina Reiss; Paul Saftig; Makoto Kuro-o; Christoph Kaether
Klotho is a substrate for alpha-, beta- and gamma-secretase.
FEBS letters 2009;583(19):3221-4.
2009: Makoto Kuro-o
Klotho and aging.
Biochimica et biophysica acta 2009;1790(10):1049-58.
2009: Seung-Kuy Cha; Ming-Chang Hu; Hiroshi Kurosu; Makoto Kuro-o; Orson W Moe; Chou-Long Huang
Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho.
Molecular pharmacology 2009;76(1):38-46.
2009: Daniela S Kempe; Teresa F Ackermann; Stephanie S Fischer; Saisudha Koka; Krishna M Boini; Hasan Mahmud; Michael Föller; Kevin P Rosenblatt; Makoto Kuro-o; Florian Lang
Accelerated suicidal erythrocyte death in Klotho-deficient mice.
Pflügers Archiv : European journal of physiology 2009;458(3):503-12.
2009: Makoto Kuro-o
Klotho in chronic kidney disease--what's new?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(6):1705-8.
2009: Hiroshi Kurosu; Makoto Kuro-o
The Klotho gene family as a regulator of endocrine fibroblast growth factors.
Molecular and cellular endocrinology 2009;299(1):72-8.
2009: Hiroshi Kurosu; Makoto Kuro-o
Endocrine fibroblast growth factors as regulators of metabolic homeostasis.
BioFactors (Oxford, England) 2009;35(1):52-60.
2008: Makoto Kuro-o
Endocrine FGFs and Klothos: emerging concepts.
Trends in endocrinology and metabolism: TEM 2008;19(7):239-45.
2008: Damian Medici; Mohammed S Razzaque; Stephelynn Deluca; Trent L Rector; Bo Hou; Kihwa Kang; Regina Goetz; Moosa Mohammadi; Makoto Kuro-o; Bjorn R Olsen; Beate Lanske
FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis.
The Journal of cell biology 2008;182(3):459-65.
2008: Seung-Kuy Cha; Bernardo Ortega; Hiroshi Kurosu; Kevin P Rosenblatt; Makoto Kuro-o; Chou-Long Huang
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9805-10.
2008: Hiroshi Kurosu; Makoto Kuro-o
The Klotho gene family and the endocrine fibroblast growth factors.
Current opinion in nephrology and hypertension 2008;17(4):368-72.
2008: Makoto Kuro-o
Klotho as a regulator of oxidative stress and senescence.
Biological chemistry 2008;389(3):233-41.
2007: Yan G Ni; Na Wang; Dian J Cao; Nita Sachan; David J Morris; Robert D Gerard; Makoto Kuro-o; Beverly Rothermel; James A Hill
FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(51):20517-22.
2007: Iddo Z Ben-Dov; Hillel Galitzer; Vardit Lavi-Moshayoff; Regina Goetz; Makoto Kuro-o; Moosa Mohammadi; Roy Sirkis; Tally Naveh-Many; Justin Silver
The parathyroid is a target organ for FGF23 in rats.
The Journal of clinical investigation 2007;117(12):4003-8.
2007: Orhan K Oz; Asghar Hajibeigi; Kevin Howard; Carolyn L Cummins; Monique Van Abel; Rene Jm Bindels; R Ann Word; Makoto Kuro-o; Charles Y C Pak; Joseph E Zerwekh
Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(12):1893-902.
2007: Hiroshi Kurosu; Mihwa Choi; Yasushi Ogawa; Addie S Dickson; Regina Goetz; Anna V Eliseenkova; Moosa Mohammadi; Kevin P Rosenblatt; Steven A Kliewer; Makoto Kuro-o
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
The Journal of biological chemistry 2007;282(37):26687-95.
2007: Yasushi Ogawa; Hiroshi Kurosu; Masaya Yamamoto; Animesh Nandi; Kevin P Rosenblatt; Regina Goetz; Anna V Eliseenkova; Moosa Mohammadi; Makoto Kuro-o
BetaKlotho is required for metabolic activity of fibroblast growth factor 21.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7432-7.
2007: Regina Goetz; Andrew Beenken; Omar A Ibrahimi; Juliya Kalinina; Shaun K Olsen; Anna V Eliseenkova; ChongFeng Xu; Thomas A Neubert; Fuming Zhang; Robert J Linhardt; Xijie Yu; Kenneth E White; Takeshi Inagaki; Steven A Kliewer; Masaya Yamamoto; Hiroshi Kurosu; Yasushi Ogawa; Makoto Kuro-o; Beate Lanske; Mohammed S Razzaque; Moosa Mohammadi
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Molecular and cellular biology 2007;27(9):3417-28.
2007: Dullei Min; Angela Panoskaltsis-Mortari; Makoto Kuro-o; Georg A Holländer; Bruce R Blazar; Kenneth I Weinberg
Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging.
Blood 2007;109(6):2529-37.
2006: Makoto Kuro-o
[Recent progress in Klotho research].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2006;43(6):674-81.
2006: Makoto Kuro-o
Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism.
Current opinion in nephrology and hypertension 2006;15(4):437-41.
2006: Hiroshi Kurosu; Yasushi Ogawa; Masayoshi Miyoshi; Masaya Yamamoto; Animesh Nandi; Kevin P Rosenblatt; Michel G Baum; Susan Schiavi; Ming-Chang Hu; Orson W Moe; Makoto Kuro-o
Regulation of fibroblast growth factor-23 signaling by klotho.
The Journal of biological chemistry 2006;281(10):6120-3.
2005: Hiroaki Masuda; Hirotaka Chikuda; Tatsuo Suga; Hiroshi Kawaguchi; Makoto Kuro-o
Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice.
Mechanisms of ageing and development 2005;126(12):1274-83.
2005: Masaya Yamamoto; Jeremy D Clark; Johanne V Pastor; Prem Gurnani; Animesh Nandi; Hiroshi Kurosu; Masayoshi Miyoshi; Yasushi Ogawa; Diego H Castrillon; Kevin P Rosenblatt; Makoto Kuro-o
Regulation of oxidative stress by the anti-aging hormone klotho.
The Journal of biological chemistry 2005;280(45):38029-34.
2005: Hiroshi Kurosu; Masaya Yamamoto; Jeremy D Clark; Johanne V Pastor; Animesh Nandi; Prem Gurnani; Owen P McGuinness; Hirotaka Chikuda; Masayuki Yamaguchi; Hiroshi Kawaguchi; Iichiro Shimomura; Yoshiharu Takayama; Joachim Herz; C Ronald Kahn; Kevin P Rosenblatt; Makoto Kuro-o
Suppression of aging in mice by the hormone Klotho.
Science (New York, N.Y.) 2005;309(5742):1829-33.
2005: Yorito Anamizu; Hiroshi Kawaguchi; Atsushi Seichi; Shinji Yamaguchi; Emiko Kawakami; Naotoshi Kanda; Shiro Matsubara; Makoto Kuro-o; Yoichi Nabeshima; Kozo Nakamura; Kiyomitsu Oyanagi
Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells.
Acta neuropathologica 2005;109(5):457-66.
2003: Koji Wakimoto; Hisako Fujimura; Takahiro Iwamoto; Toru Oka; Kinji Kobayashi; Satomi Kita; Sumiyo Kudoh; Makoto Kuro-o; Yo ichi Nabeshima; Munekazu Shigekawa; Yuji Imai; Issei Komuro
Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2003;135(1):9-15.
2002: Ken-ichi Kawano; Naoshi Ogata; Mathias Chiano; Helen Molloy; Patrick W Kleyn; Tim D Spector; Motoyuki Uchida; Takayuki Hosoi; Takao Suzuki; Hajime Orimo; Satoshi Inoue; Yo-ichi Nabeshima; Kozo Nakamura; Makoto Kuro-o; Hiroshi Kawaguchi
Klotho gene polymorphisms associated with bone density of aged postmenopausal women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(10):1744-51.
2002: Naoshi Ogata; Y Matsumura; Masataka Shiraki; K Kawano; Yu Koshizuka; Takayuki Hosoi; Kozo Nakamura; Makoto Kuro-o; Hiroshi Kawaguchi
Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women.
Bone 2002;31(1):37-42.
2002: Tetsuya Nakamura; Yuichiro Saito; Yoshio Ohyama; Hiroaki Masuda; Hiroyuki Sumino; Makoto Kuro-o; Youichi Nabeshima; Ryozo Nagai; Masahiko Kurabayashi
Production of nitric oxide, but not prostacyclin, is reduced in klotho mice.
Japanese journal of pharmacology 2002;89(2):149-56.
2001: T Yamagishi; Yuichiro Saito; Tetsuya Nakamura; S Takeda; H Kanai; Hiroyuki Sumino; Makoto Kuro-o; Yo-ichi Nabeshima; Masahiko Kurabayashi; Ryozo Nagai
Troglitazone improves endothelial function and augments renal klotho mRNA expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with multiple atherogenic risk factors.
Hypertension research : official journal of the Japanese Society of Hypertension 2001;24(6):705-9.
2001: Koji Wakimoto; Makoto Kuro-o; Noriyuki Yanaka; Issei Komuro; Yo ichi Nabeshima; Yuji Imai
Expression of Na+/Ca(2+) exchanger (NCX1) gene in the developmental mouse embryo and adult mouse brain.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2001;130(2):191-8.
2001: N Manabe; Hiroshi Kawaguchi; Hirotaka Chikuda; Chisato Miyaura; Masaki Inada; Ryozo Nagai; Yo-ichi Nabeshima; Kozo Nakamura; Angus M Sinclair; Richard Scheuermann; Makoto Kuro-o
Connection between B lymphocyte and osteoclast differentiation pathways.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2625-31.
2001: Makoto Kuro-o
Disease model: human aging.
Trends in molecular medicine 2001;7(4):179-81.
2000: Koji Wakimoto; Kinji Kobayashi; Makoto Kuro-o; Atsushi Yao; Takahiro Iwamoto; Noriyuki Yanaka; Satomi Kita; A Nishida; S Azuma; Y Toyoda; Kenji Omori; H Imahie; T Oka; Sumiyo Kudoh; Osami Kohmoto; Yoshio Yazaki; Munekazu Shigekawa; Yuji Imai; Yo ichi Nabeshima; Issei Komuro
Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat.
The Journal of biological chemistry 2000;275(47):36991-8.
2000: Yuichiro Saito; Tetsuya Nakamura; Yoshio Ohyama; Takahiro Suzuki; A Iida; T Shiraki-Iida; Makoto Kuro-o; Yo-ichi Nabeshima; Masahiko Kurabayashi; Ryozo Nagai
In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome.
Biochemical and biophysical research communications 2000;276(2):767-72.
2000: Toshihiro Utsugi; T Ohno; Yoshio Ohyama; Tsuyoshi Uchiyama; Y Saito; Y Matsumura; H Aizawa; H Itoh; Masahiko Kurabayashi; Shoji Kawazu; Shoichi Tomono; Y Oka; T Suga; Makoto Kuro-o; Y Nabeshima; Ryozo Nagai
Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging.
Metabolism: clinical and experimental 2000;49(9):1118-23.
2000: T Shiraki-Iida; A Iida; Yo-ichi Nabeshima; Hideharu Anazawa; S Nishikawa; M Noda; Makoto Kuro-o; Y Nabeshima
Improvement of multiple pathophysiological phenotypes of klotho (kl/kl) mice by adenovirus-mediated expression of the klotho gene.
The journal of gene medicine 2000;2(4):233-42.
2000: J Kiraku; T Sugiyama; T Ashida; N Takahashi; J Fujii; Makoto Kuro-o; Ryozo Nagai
Increases in intracellular calcium of arterial smooth muscle cells in transgenic mice overexpressing Na+/H+ exchanger.
Journal of cardiovascular pharmacology 2000;35(3):511-3.
2000: Y Kato; E Arakawa; S Kinoshita; A Shirai; Akiko Furuya; Kazuya Yamano; Kazuyasu Nakamura; A Iida; Hideharu Anazawa; N Koh; Akiko Iwano; Akihiro Imura; Toshihiko Fujimori; Makoto Kuro-o; Nobuo Hanai; K Takeshige; Yo-ichi Nabeshima
Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys.
Biochemical and biophysical research communications 2000;267(2):597-602.
2000: Koji Wakimoto; Makoto Kuro-o; Noriyuki Yanaka; Kenji Omori; Issei Komuro; Yuji Imai; Yo ichi Nabeshima
Isolation and characterization of Na+/Ca2+ exchanger gene and splicing isoforms in mice.
DNA sequence : the journal of DNA sequencing and mapping 2000;11(1-2):75-81.
2000: Tatsuo Suga; Masahiko Kurabayashi; Yoshichika Sando; Yoshio Ohyama; Toshitaka Maeno; Yuri Maeno; H Aizawa; Y Matsumura; T Kuwaki; Makoto Kuro-o; Yo-ichi Nabeshima; Ryozo Nagai
Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life.
American journal of respiratory cell and molecular biology 2000;22(1):26-33.
1999: Hiroshi Kawaguchi; N Manabe; Chisato Miyaura; Hirotaka Chikuda; Kozo Nakamura; Makoto Kuro-o
Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia.
The Journal of clinical investigation 1999;104(3):229-37.
1999: N Watanabe; Masahiko Kurabayashi; Y Shimomura; Keiko Kawai-Kowase; Y i Hoshino; Ichiro Manabe; M Watanabe; M Aikawa; Makoto Kuro-o; Takahiro Suzuki; Y Yazaki; Ryozo Nagai
BTEB2, a Krüppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene.
Circulation research 1999;85(2):182-91.
1999: J Kiraku; Tetsuya Nakamura; T Sugiyama; N Takahashi; Makoto Kuro-o; J Fujii; Ryozo Nagai
Dietary salt loading increases nitric oxide synthesis in transgenic mice overexpressing sodium-proton exchanger.
Japanese journal of pharmacology 1999;80(2):181-3.
1998: Yoshio Ohyama; Masahiko Kurabayashi; Hiroaki Masuda; Tetsuya Nakamura; Y Aihara; T Kaname; Tatsuo Suga; Masashi Arai; H Aizawa; Y Matsumura; Makoto Kuro-o; Yo-ichi Nabeshima; R Nagail
Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress.
Biochemical and biophysical research communications 1998;251(3):920-5.
1998: H Aizawa; Yuichiro Saito; Tetsuya Nakamura; M Inoue; T Imanari; Yoshio Ohyama; Y Matsumura; Hiroaki Masuda; S Oba; Naobumi Mise; Kenjiro Kimura; A Hasegawa; Masahiko Kurabayashi; Makoto Kuro-o; Yo-ichi Nabeshima; Ryozo Nagai
Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats.
Biochemical and biophysical research communications 1998;249(3):865-71.
1998: Yuichiro Saito; T Yamagishi; Tetsuya Nakamura; Yoshio Ohyama; H Aizawa; Tatsuo Suga; Y Matsumura; Hiroaki Masuda; Masahiko Kurabayashi; Makoto Kuro-o; Yo-ichi Nabeshima; Ryozo Nagai
Klotho protein protects against endothelial dysfunction.
Biochemical and biophysical research communications 1998;248(2):324-9.
1998: T Shiraki-Iida; H Aizawa; Y Matsumura; S Sekine; A Iida; Hideharu Anazawa; Ryozo Nagai; Makoto Kuro-o; Yo-ichi Nabeshima
Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein.
FEBS letters 1998;424(1-2):6-10.
1998: Y Matsumura; H Aizawa; T Shiraki-Iida; Ryozo Nagai; Makoto Kuro-o; Yo-ichi Nabeshima
Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein.
Biochemical and biophysical research communications 1998;242(3):626-30.
1997: Makoto Kuro-o; Y Matsumura; H Aizawa; H Kawaguchi; T Suga; T Utsugi; Y Ohyama; Masahiko Kurabayashi; T Kaname; E Kume; H Iwasaki; A Iida; T Shiraki-Iida; S Nishikawa; Ryozo Nagai; Yo-ichi Nabeshima
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
Nature 1997;390(6655):45-51.
1997: Ichiro Manabe; Masahiko Kurabayashi; Yoshiharu Shimomura; Makoto Kuro-o; Nobukazu Watanabe; Masahiko Watanabe; M Aikawa; Takahiro Suzuki; Yoshio Yazaki; Ryozo Nagai
Isolation of the embryonic form of smooth muscle myosin heavy chain (SMemb/NMHC-B) gene and characterization of its 5'-flanking region.
Biochemical and biophysical research communications 1997;239(2):598-605.
1996: M Watanabe; Yasunari Sakomura; Masahiko Kurabayashi; Ichiro Manabe; M Aikawa; Makoto Kuro-o; T Suzuki; Y Yazaki; Ryozo Nagai
Structure and characterization of the 5'-flanking region of the mouse smooth muscle myosin heavy chain (SM1/2) gene.
Circulation research 1996;78(6):978-89.
1996: T Suzuki; M Aikawa; Makoto Kuro-o; M Watanabe; K Kimura; Y Yazaki; Ryozo Nagai
Presence of contractile-type smooth muscle cells in the endocardium.
Cardiology 1996;87(1):23-7.
1996: E Okamoto; T Suzuki; M Aikawa; K Imataka; J Fujii; Makoto Kuro-o; K Nakahara; A Hasegawa; Y Yazaki; Ryozo Nagai
Diversity of the synthetic-state smooth-muscle cells proliferating in mechanically and hemodynamically injured rabbit arteries.
Laboratory investigation; a journal of technical methods and pathology 1996;74(1):120-8.
1995: K Kimura; Ryozo Nagai; T Sakai; M Aikawa; Makoto Kuro-o; N Kobayashi; Isao Shirato; Tadashi Inagami; M Oshi; Naoe Suzuki
Diversity and variability of smooth muscle phenotypes of renal arterioles as revealed by myosin isoform expression.
Kidney international 1995;48(2):372-82.
1995: Ryozo Nagai; Makoto Kuro-o; M Aikawa; M Watanabe; T Suzuki; Y Yazaki
[Smooth muscle myosin heavy chain expression in the arterial wall; a new viewpoint for vascular pathology].
Rinsho byori. The Japanese journal of clinical pathology 1995;43(4):337-41.
1995: R Nagi; N Aikawa; Makoto Kuro-o; Y Yazaki
Roles of vascular smooth muscles in atherosclerosis.
Internal medicine (Tokyo, Japan) 1995;34(4):279-81.
1995: M Aikawa; H S Kim; Makoto Kuro-o; Ichiro Manabe; M Watanabe; H Yamaguchi; Y Yazaki; Ryozo Nagai
Phenotypic modulation of smooth muscle cells during progression of human atherosclerosis as determined by altered expression of myosin heavy chain isoforms.
Annals of the New York Academy of Sciences 1995;748():578-85.
1995: Makoto Kuro-o; K Hanaoka; Yukio Hiroi; T Noguchi; Y Fujimori; S Takewaki; M Hayasaka; H Katoh; A Miyagishi; Ryozo Nagai
Salt-sensitive hypertension in transgenic mice overexpressing Na(+)-proton exchanger.
Circulation research 1995;76(1):148-53.
1995: S Takewaki; Makoto Kuro-o; Yukio Hiroi; Tadashi Yamazaki; T Noguchi; A Miyagishi; K Nakahara; M Aikawa; Ichiro Manabe; Y Yazaki
Activation of Na(+)-H+ antiporter (NHE-1) gene expression during growth, hypertrophy and proliferation of the rabbit cardiovascular system.
Journal of molecular and cellular cardiology 1995;27(1):729-42.
1993: M Aikawa; Nallasivam Palanisamy; Makoto Kuro-o; K Kimura; K Nakahara; S Takewaki; M Ueda; H Yamaguchi; Y Yazaki; Muthu Periasamy
Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis.
Circulation research 1993;73(6):1000-12.
1993: H S Kim; M Aikawa; K Kimura; Makoto Kuro-o; K Nakahara; T Suzuki; H Katoh; E Okamoto; Y Yazaki; Ryozo Nagai
Ductus arteriosus. Advanced differentiation of smooth muscle cells demonstrated by myosin heavy chain isoform expression in rabbits.
Circulation 1993;88(4 Pt 1):1804-10.
1993: Yasuhisa Fujii; H Itoyanagi; Y Saegusa; Makoto Kuro-o; Y Matsuda; Y Shiroko; Masazumi Eriguchi; K Hasumi
Establishment and characterization of BALB/c retroperitoneal sarcoma with spontaneous liver metastases.
Japanese journal of cancer research : Gann 1993;84(10):1055-61.
1993: Makoto Kuro-o; Ryozo Nagai; Y Yazaki; K Hanaoka; Y Nabeshima
[Production of transgenic mice overexpressing rabbit Na+/H+ antiporter].
Nihon rinsho. Japanese journal of clinical medicine 1993;51(6):1524-9.
1992: E Okamoto; K Imataka; J Fujii; Makoto Kuro-o; K Nakahara; H Nishimura; Y Yazaki; R Nagai
Heterogeneity in smooth muscle cell population accumulating in the neointimas and the media of poststenotic dilatation of the rabbit carotid artery.
Biochemical and biophysical research communications 1992;185(1):459-64.
1992: K Nakahara; H Nishimura; Makoto Kuro-o; S Takewaki; M Iwase; A Ohkubo; Y Yazaki; Ryozo Nagai
Identification of three types of PDGF-A chain gene transcripts in rabbit vascular smooth muscle and their regulated expression during development and by angiotensin II.
Biochemical and biophysical research communications 1992;184(2):811-8.
1991: Makoto Kuro-o; Ryozo Nagai; K Nakahara; H Katoh; R C Tsai; H Tsuchimochi; Y Yazaki; A Ohkubo; F Takaku
cDNA cloning of a myosin heavy chain isoform in embryonic smooth muscle and its expression during vascular development and in arteriosclerosis.
The Journal of biological chemistry 1991;266(6):3768-73.
1989: Makoto Kuro-o; Ryozo Nagai; H Tsuchimochi; H Katoh; Y Yazaki; A Ohkubo; F Takaku
Developmentally regulated expression of vascular smooth muscle myosin heavy chain isoforms.
The Journal of biological chemistry 1989;264(31):18272-5.
1989: R Nagai; Makoto Kuro-o; P Babij; Muthu Periasamy
Identification of two types of smooth muscle myosin heavy chain isoforms by cDNA cloning and immunoblot analysis.
The Journal of biological chemistry 1989;264(17):9734-7.
1988: K Nomoto; Issei Komuro; Makoto Kuro-o; H Tsuchimochi; F Takaku; K Machii; Y Yazaki
Differences in response of myosin isozyme transition of ordinary and specialized myocardium to overload.
Circulation research 1988;62(6):1088-92.
1988: H Tsuchimochi; Makoto Kuro-o; H Koyama; Masahiko Kurabayashi; M Sugi; F Takaku; S Furuta; Y Yazaki
Heterogeneity of beta-type myosin isozymes in the human heart and regulational mechanisms in their expression. Immunohistochemical study using monoclonal antibodies.
The Journal of clinical investigation 1988;81(1):110-8.
1986: H Tsuchimochi; Makoto Kuro-o; F Takaku; K Yoshida; M Kawana; S Kimata; Y Yazaki
Expression of myosin isozymes during the developmental stage and their redistribution induced by pressure overload.
Japanese circulation journal 1986;50(10):1044-52.
1986: Makoto Kuro-o; H Tsuchimochi; S Ueda; F Takaku; Y Yazaki
Distribution of cardiac myosin isozymes in human conduction system. Immunohistochemical study using monoclonal antibodies.
The Journal of clinical investigation 1986;77(2):340-7.
1984: Y Yazaki; H Tsuchimochi; Makoto Kuro-o; M Kurabayashi; M Isobe; S Ueda; R Nagai; F Takaku
Distribution of myosin isozymes in human atrial and ventricular myocardium: comparison in normal and overloaded heart.
European heart journal 1984;5 Suppl F():103-10.
1984: H Tsuchimochi; M Sugi; Makoto Kuro-o; S Ueda; F Takaku; S Furuta; T Shirai; Y Yazaki
Isozymic changes in myosin of human atrial myocardium induced by overload. Immunohistochemical study using monoclonal antibodies.
The Journal of clinical investigation 1984;74(2):662-5.