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Wade Adams

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Toni-Jo Poel; Richard C Thomas; Wade J Adams; Paul A Aristoff; Michael R Barbachyn; Frederick E Boyer; Joan Brieland; Roger Brideau; Joanne Brodfuehrer; Alan P Brown; Allison L Choy; Michael R Dermyer; Michael Dority; Charles W Ford; Robert C Gadwood; Debra L Hanna; Cai Hongliang; Michael D Huband; Christopher Huber; Rose Kelly; Ji-Young Kim; Joseph P Martin; Paul J Pagano; Daniel Ross; Laura Skerlos; Mark C Sulavik; Tong Zhu; Gary E Zurenko; J V N Vara Prasad
Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.
Thomas Lanz; John D Hosley; Wade J Adams; Kalpana M Merchant
Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575).
Fred Ciske; Michael R Barbachyn; Michael J Genin; Kevin C Grega; Chi Sing Lee; Lester A Dolak; Eric P Seest; William Watt; Wade J Adams; Janice M Friis; Charles W Ford; Gary E Zurenko
The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones.

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All Publications

2007: Toni-Jo Poel; Richard C Thomas; Wade J Adams; Paul A Aristoff; Michael R Barbachyn; Frederick E Boyer; Joan Brieland; Roger Brideau; Joanne Brodfuehrer; Alan P Brown; Allison L Choy; Michael R Dermyer; Michael Dority; Charles W Ford; Robert C Gadwood; Debra L Hanna; Cai Hongliang; Michael D Huband; Christopher Huber; Rose Kelly; Ji-Young Kim; Joseph P Martin; Paul J Pagano; Daniel Ross; Laura Skerlos; Mark C Sulavik; Tong Zhu; Gary E Zurenko; J V N Vara Prasad
Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.
Journal of medicinal chemistry 2007;50(24):5886-9.
2004: Thomas Lanz; John D Hosley; Wade J Adams; Kalpana M Merchant
Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575).
The Journal of pharmacology and experimental therapeutics 2004;309(1):49-55.
2003: Fred Ciske; Michael R Barbachyn; Michael J Genin; Kevin C Grega; Chi Sing Lee; Lester A Dolak; Eric P Seest; William Watt; Wade J Adams; Janice M Friis; Charles W Ford; Gary E Zurenko
The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones.
Bioorganic & medicinal chemistry letters 2003;13(23):4235-9.
2003: Upinder Singh; B Raju; Stuart Lam; Joseph Zhou; Robert C Gadwood; Charles W Ford; Gary E Zurenko; Ronda D Schaadt; Sara E Morin; Wade J Adams; Janice M Friis; Maria Courtney; Joe Palandra; Corinne Hackbarth; Lopez Sara; Charlotte Wu; Kathleen H Mortell; Joaquim Trias; Zhengyu Yuan; Dinesh V Patel; Mikhail F Gordeev
New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones.
Bioorganic & medicinal chemistry letters 2003;13(23):4209-12.
2003: Allen R Hilgers; Donald P Smith; John J Biermacher; Jeffrey S Day; Jana L Jensen; Sandra M Sims; Wade J Adams; Janice M Friis; Joe Palandra; John D Hosley; Eric M Shobe; Philip S Burton
Predicting oral absorption of drugs: a case study with a novel class of antimicrobial agents.
Pharmaceutical research 2003;20(8):1149-55.
2003: Michael R Barbachyn; Gary J Cleek; Lester A Dolak; Stuart A Garmon; Joel Morris; Eric P Seest; Richard C Thomas; Dana S Toops; William Watt; Donn G Wishka; Charles W Ford; Gary E Zurenko; Judith C Hamel; Ronda D Schaadt; Douglas Stapert; Betty H Yagi; Wade J Adams; Janice M Friis; John Gregory Slatter; James Peter Sams; Nancee L Oien; Matthew J Zaya; Larry C Wienkers; Michael A Wynalda
Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens.
Journal of medicinal chemistry 2003;46(2):284-302.
1999: Michael J Genin; Toni-Jo Poel; P D May; Laurice A Kopta; Y Yagi; RA Olmsted; Janice M Friis; R L Voorman; Wade J Adams; Richard C Thomas; DL Romero
Synthesis and structure-activity relationships of the (alkylamino)piperidine-containing BHAP class of non-nucleoside reverse transcriptase inhibitors: effect of 3-alkylpyridine ring substitution.
Journal of medicinal chemistry 1999;42(20):4140-9.
1998: Michael J Genin; DK Hutchinson; DA Allwine; JB Hester; DE Emmert; Stuart A Garmon; Charles W Ford; Gary E Zurenko; Judith C Hamel; Ronda D Schaadt; Douglas Stapert; Betty H Yagi; Janice M Friis; Eric M Shobe; Wade J Adams
Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis.
Journal of medicinal chemistry 1998;41(26):5144-7.
1998: Donn G Wishka; DR Graber; Laurice A Kopta; RA Olmsted; Janice M Friis; John D Hosley; Wade J Adams; Eric P Seest; T M Castle; Lester A Dolak; BJ Keiser; Y Yagi; A Jeganathan; ST Schlachter; M J Murphy; Gary J Cleek; Richard A Nugent; Susan M Poppe; SM Swaney; F Han; William Watt; W L White; Toni-Jo Poel; Richard C Thomas; Joel Morris
(-)-6-Chloro-2-[(1-furo[2, 3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor.
Journal of medicinal chemistry 1998;41(9):1357-60.
1998: Wade J Adams; Paul A Aristoff; R K Jensen; W Morozowich; DL Romero; W C Schinzer; WG Tarpley; Richard C Thomas
Discovery and development of the BHAP nonnucleoside reverse transcriptase inhibitor delavirdine mesylate.
Pharmaceutical biotechnology 1998;11():285-312.
1996: Michael J Genin; Toni-Jo Poel; Y Yagi; C Biles; I Althaus; B J Keiser; Laurice A Kopta; Janice M Friis; F Reusser; Wade J Adams; R A Olmsted; R L Voorman; Richard C Thomas; D L Romero
Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs.
Journal of medicinal chemistry 1996;39(26):5267-75.
1996: D L Romero; R A Olmsted; Toni-Jo Poel; R A Morge; C Biles; B J Keiser; Laurice A Kopta; Janice M Friis; J D Hosley; K J Stefanski; D G Wishka; D B Evans; Joel Morris; R G Stehle; S K Sharma; Y Yagi; R L Voorman; Wade J Adams; WG Tarpley; Richard C Thomas
Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Journal of medicinal chemistry 1996;39(19):3769-89.
1995: B A Staton; M G Johnson; J M Friis; Wade J Adams
Simple, rapid and sensitive high-performance liquid chromatographic determination of delavirdine and its N-desisopropyl metabolite in human plasma.
Journal of chromatography. B, Biomedical applications 1995;668(1):99-106.
1993: G R Weiss; T D Brown; John Kuhn; Daniel Von Hoff; R H Earhart; Wade J Adams; J E Brewer; J D Hosley; D A Kasunic
A phase I clinical and pharmacokinetic study of the oral and the oral/intravenous administration of menogaril.
Investigational new drugs 1993;11(1):17-27.
1991: D J Porubek; S M Sanins; J R Stephens; M P Grillo; D G Kaiser; G W Halstead; Wade J Adams; Thomas A Baillie
Metabolic chiral inversion of flurbiprofen-CoA in vitro.
Biochemical pharmacology 1991;42(1):R1-4.
1991: S M Sanins; Wade J Adams; D G Kaiser; G W Halstead; J Hosley; H Barnes; Thomas A Baillie
Mechanistic studies on the metabolic chiral inversion of R-ibuprofen in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(2):405-10.
1990: S M Sanins; Wade J Adams; D G Kaiser; G W Halstead; Thomas A Baillie
Studies on the metabolism and chiral inversion of ibuprofen in isolated rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(4):527-33.
1990: T J Bichay; E G Adams; W R Inch; Wade J Adams; J E Brewer; B K Bhuyan
HPLC and flow cytometric analyses of uptake of adriamycin and menogaril by monolayers and multicell spheroids.
Selective cancer therapeutics 1990;6(4):153-66.
1989: Wade J Adams; J P McGovren; E A Dalm; J E Brewer; J D Hosley
Pharmacokinetics and systemic bioavailability of menogaril, an anthracycline antitumor agent, in the mouse, dog, and monkey.
Cancer research 1989;49(22):6328-36.
1989: H Ko; J F Caputo; Wade J Adams
Noncompartmental analysis for a one-compartment model with equal absorption and elimination rate constants.
Pharmaceutical research 1989;6(8):731-3.
1989: P A Bombardt; B E Bothwell; S K Closson; Wade J Adams
Quantitative determination of itazigrel in rodent diet by reversed-phase HPLC and evaluation of its stability at 20 degrees C.
Biomedical chromatography : BMC 1989;3(4):180-2.
1989: Thomas A Baillie; Wade J Adams; D G Kaiser; L S Olanoff; G W Halstead; H Harpootlian; G J Van Giessen
Mechanistic studies of the metabolic chiral inversion of (R)-ibuprofen in humans.
The Journal of pharmacology and experimental therapeutics 1989;249(2):517-23.
1989: H Ko; E Novak; GR Peters; W M Bothwell; J D Hosley; S K Closson; Wade J Adams
Pharmacokinetics of single-dose cefmetazole following intramuscular administration of cefmetazole sodium to healthy male volunteers.
Antimicrobial agents and chemotherapy 1989;33(4):508-12.
1989: H Ko; K S Cathcart; D L Griffith; GR Peters; Wade J Adams
Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination.
Antimicrobial agents and chemotherapy 1989;33(3):356-61.
1987: Wade J Adams; B E Bothwell; W M Bothwell; G J VanGiessen; D G Kaiser
Simultaneous determination of flurbiprofen and its major metabolite in physiological fluids using liquid chromatography with fluorescence detection.
Analytical chemistry 1987;59(11):1504-9.
1986: P Dodion; C Sessa; R Joss; N Crespeigne; Y Willems; M Kitt; J Abrams; C Finet; J E Brewer; Wade J Adams
Phase I study of intravenous menogaril administered intermittently.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1986;4(5):767-74.
1984: Wade J Adams; P A Bombardt; J E Brewer
Normal-phase liquid chromatographic determination of alprazolam in human serum.
Analytical chemistry 1984;56(9):1590-4.
1984: J P McGovren; R D Hamilton; Wade J Adams; E A Pratt
Quantitation of anthracycline antitumor agent menogarol in plasma using liquid chromatography with fluorescence detection.
Analytical chemistry 1984;56(9):1587-90.
1982: Wade J Adams; G S Skinner; P A Bombardt; M Courtney; J E Brewer
Determination of glyburide in human serum by liquid chromatography with fluorescence detection.
Analytical chemistry 1982;54(8):1287-91.