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Yuji Kurokawa

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Guang-Xun Li; Yoko Hirabayashi; Byung-Il Yoon; Yasushi Kawasaki; Isao Tsuboi; Yukio Kodama; Yuji Kurokawa; Junji Yodoi; Jun Kanno; Tohru Inoue
Thioredoxin overexpression in mice, model of attenuation of oxidative stress, prevents benzene-induced hemato-lymphoid toxicity and thymic lymphoma.
Takashi Umemura; Yuji Kurokawa
Etiology of bromate-induced cancer and possible modes of action-studies in Japan.
Takashi Umemura; Yukio Kodama; Akiyoshi Nishikawa; Kyoji Hioki; Tatsuji Nomura; Keita Kanki; Yuichi Kuroiwa; Yuji Ishii; Yuji Kurokawa; Masao Hirose
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.

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2006: Guang-Xun Li; Yoko Hirabayashi; Byung-Il Yoon; Yasushi Kawasaki; Isao Tsuboi; Yukio Kodama; Yuji Kurokawa; Junji Yodoi; Jun Kanno; Tohru Inoue
Thioredoxin overexpression in mice, model of attenuation of oxidative stress, prevents benzene-induced hemato-lymphoid toxicity and thymic lymphoma.
Experimental hematology 2006;34(12):1687-97.
2006: Takashi Umemura; Yuji Kurokawa
Etiology of bromate-induced cancer and possible modes of action-studies in Japan.
Toxicology 2006;221(2-3):154-7.
2006: Takashi Umemura; Yukio Kodama; Akiyoshi Nishikawa; Kyoji Hioki; Tatsuji Nomura; Keita Kanki; Yuichi Kuroiwa; Yuji Ishii; Yuji Kurokawa; Masao Hirose
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.
Cancer letters 2006;231(2):314-8.
2003: Yoko Hirabayashi; Kazuko Yoshida; Shin-ichi Aizawa; Yukio Kodama; Jun Kanno; Yuji Kurokawa; Isao Yoshimura; Tohru Inoue
Evaluation of nonthreshold leukemogenic response to methyl nitrosourea in p53-deficient C3H/He mice.
Toxicology and applied pharmacology 2003;190(3):251-61.
2002: Takashi Umemura; Yukio Kodama; Kyoji Hioki; Tatsuji Nomura; Akiyoshi Nishikawa; Masao Hirose; Yuji Kurokawa
The mouse rasH2/BHT model as an in vivo rapid assay for lung carcinogens.
Japanese journal of cancer research : Gann 2002;93(8):861-6.
2001: Takashi Umemura; Yukio Kodama; Kyoji Hioki; Tohru Inoue; Tatsuji Nomura; Yuji Kurokawa
Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis.
Journal of cancer research and clinical oncology 2001;127(10):583-90.
2001: Kiyoshi Sekita; Takashi Umemura; Minoru Saito; Yukio Ogawa; K Ueno; Toyozo Kaneko; Osayuki Uchida; Yuko Matsushima; Yoko Kawasaki; Yuji Kurokawa; Tohru Inoue
[Fukuronori (Gloiopeltis furcata) extract: 90-day dietary toxicity study in F344 rats].
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 2001;42(2):96-101.
2000: Takashi Umemura; Yukio Kodama; Yuji Kurokawa; Gary M Williams
Lack of oxidative DNA damage or initiation of carcinogenesis in the kidneys of male F344 rats given subchronic exposure to p-dichlorobenzene (pDCB) at a carcinogenic dose.
Archives of toxicology 2000;74(1):54-9.
1999: Atsushi Ono; K Kawashima; Kiyoshi Sekita; Akihiko Hirose; Yukio Ogawa; Minoru Saito; K Naito; Kazuo Yasuhara; Toyozo Kaneko; T Furuya; Tohru Inoue; Yuji Kurokawa
Toluene inhalation induced epididymal sperm dysfunction in rats.
Toxicology 1999;139(3):193-205.
1999: Takashi Umemura; Yukio Kodama; Kyoji Hioki; Tohru Inoue; Tatsuji Nomura; Yuji Kurokawa
Susceptibility to urethane carcinogenesis of transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice) and its modification by butylhydroxytoluene.
Cancer letters 1999;145(1-2):101-6.
1999: Minoru Saitoh; Takashi Umemura; Yasushi Kawasaki; J Momma; Yuko Matsushima; Kazue Sakemi; Kazuo Isama; S Kitajima; Y Ogawa; Ryuichi Hasegawa; Takayoshi Suzuki; Makoto Hayashi; Tohru Inoue; Yasuo Ohno; Toshio Sofuni; Yuji Kurokawa; Mitsuhiro Tsuda
Toxicity study of a rubber antioxidant, mixture of 2-mercaptomethylbenzimidazoles, by repeated oral administration to rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1999;37(7):777-87.
1999: Takashi Umemura; Sachie Kai; Ryuichi Hasegawa; K Sai; Yuji Kurokawa; Gary M Williams
Pentachlorophenol (PCP) produces liver oxidative stress and promotes but does not initiate hepatocarcinogenesis in B6C3F1 mice.
Carcinogenesis 1999;20(6):1115-20.
1998: K Sai; Sachie Kai; Takashi Umemura; A Tanimura; Ryuichi Hasegawa; Tohru Inoue; Yuji Kurokawa
Protective effects of green tea on hepatotoxicity, oxidative DNA damage and cell proliferation in the rat liver induced by repeated oral administration of 2-nitropropane.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1998;36(12):1043-51.
1998: Takashi Umemura; A Takagi; K Sai; Ryuichi Hasegawa; Yuji Kurokawa
Oxidative DNA damage and cell proliferation in kidneys of male and female rats during 13-weeks exposure to potassium bromate (KBrO3).
Archives of toxicology 1998;72(5):264-9.
1998: Takashi Umemura; K Takada; C Schulz; Rolf Gebhardt; Yuji Kurokawa; Gary M Williams
Cell proliferation in the livers of male mice and rats exposed to the carcinogen P-dichlorobenzene: evidence for thresholds.
Drug and chemical toxicology 1998;21(1):57-66.
1998: Yasushi Kawasaki; Takashi Umemura; Minoru Saito; J Momma; Yuko Matsushima; H Sekiguchi; Mariko Matsumoto; Kazue Sakemi; Kazuo Isama; Tohru Inoue; Yuji Kurokawa; Mitsuhiro Tsuda
Toxicity study of a rubber antioxidant, 2-mercaptobenzimidazole, by repeated oral administration to rats.
The Journal of toxicological sciences 1998;23(1):53-68.
1998: Kunitoshi Mitsumori; Takayoshi Imazawa; Hiroshi Onodera; Mika Takahashi; S Kitajima; Tohru Inoue; Yuji Kurokawa
Ultrastructural changes in motor endplates of the lumbrical muscles of rats induced by a microsomal Ca2+ ATPase inhibitor, 2,5-di(tert-butyl)-1,4-hydroquinone.
Archives of toxicology 1998;72(2):115-8.
1997: Eiichi Kamata; M Nakadate; Osayuki Uchida; Yukio Ogawa; S Suzuki; Toyozo Kaneko; Minoru Saito; Yuji Kurokawa
Results of a 28-month chronic inhalation toxicity study of formaldehyde in male Fisher-344 rats.
The Journal of toxicological sciences 1997;22(3):239-54.
1996: Yuji Kurokawa; T Matsuzawa
Single dose toxicity and repeated dose toxicity studies: introductory remarks.
The Journal of toxicological sciences 1996;21(5):413-6.
1996: Takashi Umemura; Ryuichi Hasegawa; K Sai-Kato; A Nishikawa; F Furukawa; S Toyokuni; K Uchida; T Inoue; Yuji Kurokawa
Prevention by 2-mercaptoethane sulfonate and N-acetylcysteine of renal oxidative damage in rats treated with ferric nitrilotriacetate.
Japanese journal of cancer research : Gann 1996;87(9):882-6.
1996: R Akasaka; R Teshima; S Kitajima; J Momma; Tohru Inoue; Yuji Kurokawa; H Ikebuchi; Jun-ichi Sawada
Effects of hydroquinone-type and phenolic antioxidants on calcium signals and degranulation of RBL-2H3 cells.
Biochemical pharmacology 1996;51(11):1513-9.
1996: Takashi Umemura; K Sai-Kato; A Takagi; Ryuichi Hasegawa; Yuji Kurokawa
Oxidative DNA damage and cell proliferation in the livers of B6C3F1 mice exposed to pentachlorophenol in their diet.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1996;30(2):285-9.
1996: Yuji Kurokawa
Current status of the international toxicology guidelines, focusing on the OECD and ICH guidelines.
The Journal of toxicological sciences 1996;21(1):65-7.
1996: A Ono; K Sekita; Yukio Ogawa; A Hirose; S Suzuki; Minoru Saito; K Naito; Toyozo Kaneko; T Furuya; K Kawashima; K Yasuhara; K Matsumoto; S Tanaka; Tohru Inoue; Yuji Kurokawa
Reproductive and developmental toxicity studies of toluene. II. Effects of inhalation exposure on fertility in rats.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 1996;15(1):9-20.
1996: E Kamata; M Nakadate; O Uchida; Yukio Ogawa; Toyozo Kaneko; Yuji Kurokawa
Effects of formaldehyde vapor on the nasal cavity and lungs of F-344 rats.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 1996;15(1):1-8.
1996: A Takagi; K Takada; K Sai; J Momma; Y Aida; S Suzuki; K Naitoh; M Tobe; Ryuichi Hasegawa; Yuji Kurokawa
Chronic oral toxicity of a synthetic antioxidant, 2,2'-methylenebis(4-ethyl- 6-tert-butylphenol), in rats.
Journal of applied toxicology : JAT 1996;16(1):15-23.
1995: Ryuichi Hasegawa; T Chujo; K Sai-Kato; Takashi Umemura; A Tanimura; Yuji Kurokawa
Preventive effects of green tea against liver oxidative DNA damage and hepatotoxicity in rats treated with 2-nitropropane.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(11):961-70.
1995: M Sato; T Xi; Akitada Nakamura; Yasushi Kawasaki; Takashi Umemura; Mitsuhiro Tsuda; Yuji Kurokawa
Degradation of polyetherurethane by subcutaneous implantation into rats. II. Changes of contact angles, infrared spectra, and nuclear magnetic resonance spectra.
Journal of biomedical materials research 1995;29(10):1201-13.
1995: K Sai-Kato; Takashi Umemura; A Takagi; Ryuichi Hasegawa; A Tanimura; Yuji Kurokawa
Pentachlorophenol-induced oxidative DNA damage in mouse liver and protective effect of antioxidants.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(10):877-82.
1995: K Sai-Kato; A Takagi; Takashi Umemura; Ryuichi Hasegawa; Yuji Kurokawa
Role of oxidative stress in non-genotoxic carcinogenesis with special reference to liver tumors induced by peroxisome proliferators.
Biomedical and environmental sciences : BES 1995;8(3):269-79.
1995: S Kitajima; J Momma; M Tsuda; Yuji Kurokawa; R Teshima; Jun-ichi Sawada
Effects of 2,5-di(tert-butyl)-1,4-hydroquinone on intracellular free Ca2+ levels and histamine secretion in RBL-2H3 cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1995;44(8):335-9.
1995: A Takagi; K Sai; Takashi Umemura; Ryuichi Hasegawa; Yuji Kurokawa
Inhibitory effects of vitamin E and ellagic acid on 8-hydroxydeoxyguanosine formation in liver nuclear DNA of rats treated with 2-nitropropane.
Cancer letters 1995;91(1):139-44.
1995: Takashi Umemura; K Sai; A Takagi; Ryuichi Hasegawa; Yuji Kurokawa
A possible role for oxidative stress in potassium bromate (KBrO3) carcinogenesis.
Carcinogenesis 1995;16(3):593-7.
1995: Akitada Nakamura; S Kojima; Kazuo Isama; Takashi Umemura; Yasushi Kawasaki; K Takada; Mitsuhiro Tsuda; Yuji Kurokawa
The effects of oligomers content and surface morphology on foreign-body tumorigenesis with polyetherurethanes: two years subcutaneous implantation study in rats.
Journal of long-term effects of medical implants 1995;5(4):263-73.
1994: K Sai; Charles A Tyson; D W Thomas; Jack Dabbs; Ryuichi Hasegawa; Yuji Kurokawa
Oxidative DNA damage induced by potassium bromate in isolated rat renal proximal tubules and renal nuclei.
Cancer letters 1994;87(1):1-7.
1994: Kunitoshi Mitsumori; Y Kodama; O Uchida; K Takada; Minoru Saito; K Naito; S Tanaka; Yuji Kurokawa; M Usami; K Kawashima
Confirmation study, using nitrobenzene, of the Combined Repeat Dose and Reproductive/Developmental Toxicity Test protocol proposed by the Organization for Economic Cooperation and Development (OECD).
The Journal of toxicological sciences 1994;19(3):141-9.
1994: Y Hayashi; K Toyoda; Takayoshi Imazawa; H Sato; H Okamiya; Yuji Kurokawa; J Takahashi; T Mogami-Nishimaki; S Hayakawa
Peroxisome proliferation of hepatocytes in rats by a microbial degradation product of cholic acid, 4-(decahydro-6-methyl-3-oxocyclopenta(f)quinoline-7-yl)valeric acid.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1994;46(2):127-32.
1993: A Takagi; N Kawasaki; J Momma; Y Aida; Y Ohno; Ryuichi Hasegawa; Yuji Kurokawa
Toxicity studies of a synthetic antioxidant, 2,2'-methylenebis (4-ethyl-6-tert-butylphenol) in rats. 2. Uncoupling effect on oxidative phosphorylation of liver mitochondria.
The Journal of toxicological sciences 1993;18(1):49-55.
1993: Takashi Umemura; K Sai; A Takagi; Ryuichi Hasegawa; Yuji Kurokawa
A possible role for cell proliferation in potassium bromate (KBrO3) carcinogenesis.
Journal of cancer research and clinical oncology 1993;119(8):463-9.
1992: Y Aida; K Takada; O Uchida; K Yasuhara; Yuji Kurokawa; M Tobe
Toxicities of microencapsulated tribromomethane, dibromochloromethane and bromodichloromethane administered in the diet to Wistar rats for one month.
The Journal of toxicological sciences 1992;17(3):119-33.
1992: A Takagi; J Momma; Y Aida; K Takada; S Suzuki; K Naitoh; M Tobe; Ryuichi Hasegawa; Yuji Kurokawa
Toxicity studies of a synthetic antioxidant, 2,2'-methylenebis (4-ethyl-6-tert-butylphenol) in rats. 1. Acute and subchronic toxicity.
The Journal of toxicological sciences 1992;17(3):135-53.
1992: A Takagi; K Sai; Takashi Umemura; Ryuichi Hasegawa; Yuji Kurokawa
Hepatomegaly is an early biomarker for hepatocarcinogenesis induced by peroxisome proliferators.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 1992;11(3):145-9.
1992: K Sai; A Takagi; Takashi Umemura; Ryuichi Hasegawa; Yuji Kurokawa
Changes of 8-hydroxydeoxyguanosine levels in rat organ DNA during the aging process.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 1992;11(3):139-43.
1992: Y Aida; K Yasuhara; K Takada; Yuji Kurokawa; M Tobe
Chronic toxicity of microencapsulated bromodichloromethane administered in the diet to Wistar rats.
The Journal of toxicological sciences 1992;17(2):51-68.
1992: K Sai; S Uchiyama; Y Ohno; Ryuichi Hasegawa; Yuji Kurokawa
Generation of active oxygen species in vitro by the interaction of potassium bromate with rat kidney cell.
Carcinogenesis 1992;13(3):333-9.
1992: S Tanaka; K Kawashima; K Naito; M Usami; M Nakadate; K Imaida; M Takahashi; Y Hayashi; Yuji Kurokawa; M Tobe
Combined Repeat Dose and Reproductive/Developmental Toxicity Screening Test (OECD): familiarization using cyclophosphamide.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1992;18(1):89-95.
1992: K Sai; Takashi Umemura; A Takagi; Ryuichi Hasegawa; Yuji Kurokawa
The protective role of glutathione, cysteine and vitamin C against oxidative DNA damage induced in rat kidney by potassium bromate.
Japanese journal of cancer research : Gann 1992;83(1):45-51.
1991: K Takada; K Naito; K Kobayashi; M Tobe; Yuji Kurokawa; M Fukuoka
Carcinogenic effects of bis(2,3-dibromopropyl)-phosphate in Wistar rats.
Journal of applied toxicology : JAT 1991;11(5):323-31.
1991: A Maekawa; Y Matsushima; Hiroshi Onodera; Makoto Shibutani; J Yoshida; Y Kodama; Yuji Kurokawa; Y Hayashi
Long-term toxicity/carcinogenicity study of calcium lactate in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1991;29(9):589-94.
1991: Takashi Umemura; K Sai; A Takagi; Ryuichi Hasegawa; Yuji Kurokawa
The effects of exogenous glutathione and cysteine on oxidative stress induced by ferric nitrilotriacetate.
Cancer letters 1991;58(1-2):49-56.
1991: A Takagi; K Sai; Takashi Umemura; Ryuichi Hasegawa; Yuji Kurokawa
Short-term exposure to the peroxisome proliferators, perfluorooctanoic acid and perfluorodecanoic acid, causes significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats.
Cancer letters 1991;57(1):55-60.
1991: K Sai; A Takagi; Takashi Umemura; Ryuichi Hasegawa; Yuji Kurokawa
Relation of 8-hydroxydeoxyguanosine formation in rat kidney to lipid peroxidation, glutathione level and relative organ weight after a single administration of potassium bromate.
Japanese journal of cancer research : Gann 1991;82(2):165-9.
1990: Takashi Umemura; K Sai; A Takagi; Ryuichi Hasegawa; Yuji Kurokawa
Oxidative DNA damage, lipid peroxidation and nephrotoxicity induced in the rat kidney after ferric nitrilotriacetate administration.
Cancer letters 1990;54(1-2):95-100.
1990: A Takagi; K Sai; Takashi Umemura; Ryuichi Hasegawa; Yuji Kurokawa
Relationship between hepatic peroxisome proliferation and 8-hydroxydeoxyguanosine formation in liver DNA of rats following long-term exposure to three peroxisome proliferators; di(2-ethylhexyl) phthalate, aluminium clofibrate and simfibrate.
Cancer letters 1990;53(1):33-8.
1990: A Maekawa; Yuko Matsushima; Hiroshi Onodera; Makoto Shibutani; H Ogasawara; Y Kodama; Yuji Kurokawa; Y Hayashi
Long-term toxicity/carcinogenicity of musk xylol in B6C3F1 mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1990;28(8):581-6.
1990: Yuji Kurokawa; A Maekawa; M Takahashi; Y Hayashi
Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen.
Environmental health perspectives 1990;87():309-35.
1990: A Takagi; K Sai; Takashi Umemura; Ryuichi Hasegawa; Yuji Kurokawa
Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate.
Japanese journal of cancer research : Gann 1990;81(3):213-5.
1990: Takashi Umemura; K Sai; A Takagi; Ryuichi Hasegawa; Yuji Kurokawa
Formation of 8-hydroxydeoxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA).
Carcinogenesis 1990;11(2):345-7.
1989: M Tobe; K Naito; Yuji Kurokawa
Chronic toxicity study on formaldehyde administered orally to rats.
Toxicology 1989;56(1):79-86.
1989: Yuko Matsushima; Hiroshi Onodera; T Nagaoka; A Todate; Makoto Shibutani; A Maekawa; Yuji Kurokawa; Y Hayashi
[Subchronic oral toxicity study of calcium lactate in F344 rats].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1989;(107):78-83.
1989: Y Ogawa; E Kamata; S Suzuki; K Kobayashi; K Naito; T Kaneko; Yuji Kurokawa; M Tobe
[Toxicity of 2-mercaptobenzothiazole in mice].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1989;(107):44-50.
1989: E Kamata; K Naito; Y Nakaji; Y Ogawa; S Suzuki; T Kaneko; K Takada; Yuji Kurokawa; M Tobe
[Acute and subacute toxicity studies of tris (1,3-dichloro-2-propyl) phosphate on mice].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1989;(107):36-43.
1989: J Momma; O Uchida; K Takada; Y Aida; H Yoshimoto; Y Suzuki; K Kobayashi; Y Nakaji; Yuji Kurokawa; M Tobe
[Combined long-term toxicity/carcinogenicity test of alpha-bromocinnamic aldehyde (BCA) applied to female mouse skin].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1989;(107):29-36.
1988: Yuji Kurokawa; N Takamura; Y Matushima; T Imazawa; Y Hayashi
Promoting effect of peroxisome proliferators in two-stage rat renal tumorigenesis.
Cancer letters 1988;43(1-2):145-9.
1988: Y Ogawa; S Suzuki; O Uchida; E Kamata; M Saito; T Umemura; M Wakana; T Kaneko; Yuji Kurokawa; M Tobe
[28-day repeated dose toxicity test of chlorpyrifos in Wistar rat].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1988;(106):48-54.