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Hitoshi Kurose

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Islam A A E-H Ibrahim; Michio Nakaya; Hitoshi Kurose
Ezrin, Radixin, and Moesin Phosphorylation in NIH3T3 Cells Revealed Angiotensin II Type 1 Receptor Cell-Type-Dependent Biased Signaling.
Noriko Makita; Michio Nakaya; Masaomi Nangaku; Hiroaki Nishihara; Tomohiko Ohwada; Yuko Otani; Junichiro Sato; Makiko Hashimoto; Yoji Kabasawa; Hitoshi Kurose; Taroh Iiri
Attenuated desensitization of β-adrenergic receptor by water-soluble N-nitrosamines that induce S-nitrosylation without NO release.
Michio Nakaya; Takeo Nakaya; Motohiro Nishida; Hiroaki Nishihara; Mina Ohba; Yoji Sato; Mitsuru Tajima; Naoki Tani; Hisaaki Taniguchi; Makoto Tsuda; Kenji Watari; Akiko Hashimoto; Kazuhide Inoue; Shiori Komiya; Hidetaka Kosako; Masahiko Kuroda; Mitsuru Matsumoto; Hitoshi Kurose
GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.

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All Publications

2013: Islam A A E-H Ibrahim; Michio Nakaya; Hitoshi Kurose
Ezrin, Radixin, and Moesin Phosphorylation in NIH3T3 Cells Revealed Angiotensin II Type 1 Receptor Cell-Type-Dependent Biased Signaling.
Journal of pharmacological sciences 2013;122(1):1-9.
2013: Noriko Makita; Michio Nakaya; Masaomi Nangaku; Hiroaki Nishihara; Tomohiko Ohwada; Yuko Otani; Junichiro Sato; Makiko Hashimoto; Yoji Kabasawa; Hitoshi Kurose; Taroh Iiri
Attenuated desensitization of β-adrenergic receptor by water-soluble N-nitrosamines that induce S-nitrosylation without NO release.
Circulation research 2013;112(2):327-34.
2013: Michio Nakaya; Takeo Nakaya; Motohiro Nishida; Hiroaki Nishihara; Mina Ohba; Yoji Sato; Mitsuru Tajima; Naoki Tani; Hisaaki Taniguchi; Makoto Tsuda; Kenji Watari; Akiko Hashimoto; Kazuhide Inoue; Shiori Komiya; Hidetaka Kosako; Masahiko Kuroda; Mitsuru Matsumoto; Hitoshi Kurose
GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.
Nature communications 2013;4():1532.
2012: Motohiro Nishida; Katsuhiko Ono; Tomohiro Sawa; Takahiro Shibata; Makoto Suematsu; Koji Uchida; Albert van der Vliet; Masayuki Yamamoto; Bruce A Freeman; Hideshi Ihara; Hirofumi Inoue; Naoyuki Kitajima; Yoshito Kumagai; Hitoshi Kurose; Hozumi Motohashi; Takaaki Akaike
Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration.
Nature chemical biology 2012;8(8):714-24.
2012: Islam A A E-H Ibrahim; Hitoshi Kurose
β-arrestin-mediated signaling improves the efficacy of therapeutics.
Journal of pharmacological sciences 2012;118(4):408-12.
2011: Kinue Nishioka; Shota Saiki; Yoji Sato; Michio Nakaya; Motohiro Nishida; Marina Ariyoshi; Katsuya Hirano; Mayumi Hirano; Ryuji Inoue; Takahiro Iwamoto; Zhong Jian; Satomi Kita; Hitoshi Kurose
Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(10):2278-86.
2011: Motohiro Nishida; Shota Saiki; Naoyuki Kitajima; Michio Nakaya; Hitoshi Kurose
Regulation of Angiotensin II receptor signaling by cysteine modification of NF-κB.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2011;25(2):112-7.
2011: Naoyuki Kitajima; Kunihiro Watanabe; Sachio Morimoto; Yoji Sato; Shigeki Kiyonaka; Masahiko Hoshijima; Yasuhiro Ikeda; Michio Nakaya; Tomomi Ide; Yasuo Mori; Hitoshi Kurose; Motohiro Nishida
TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts.
Biochemical and biophysical research communications 2011;409(1):108-13.
2011: Motohiro Nishida; Mariko Ogushi; Reiko Suda; Miyuki Toyotaka; Shota Saiki; Naoyuki Kitajima; Michio Nakaya; Kyeong-Man Kim; Tomomi Ide; Yoji Sato; Kazuhide Inoue; Hitoshi Kurose
Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kappaB.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(16):6662-7.
2011: Michio Nakaya; Motohiro Nishida; Mina Ohba; Hitoshi Kurose
Determining the activation of rho as an index of receptor coupling to G₁₂/₁₃ proteins.
Methods in molecular biology (Clifton, N.J.) 2011;746():317-27.
2010: Motohiro Nishida; Shota Saiki; Naoyuki Kitajima; Michio Nakaya; Yoji Sato; Hitoshi Kurose
[Regulation of cardiovascular functions by the phosphorylation of TRPC channels].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(11):1427-33.
2010: Motohiro Nishida; Reiko Suda; Yuichi Nagamatsu; Shihori Tanabe; Naoya Onohara; Michio Nakaya; Yasunori Kanaho; Takahiro Shibata; Koji Uchida; Hideki Sumimoto; Yoji Sato; Hitoshi Kurose
Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation.
The Journal of biological chemistry 2010;285(20):15268-77.
2010: Motohiro Nishida; Kenta Watanabe; Yoji Sato; Michio Nakaya; Naoyuki Kitajima; Tomomi Ide; Ryuji Inoue; Hitoshi Kurose
Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition.
The Journal of biological chemistry 2010;285(17):13244-53.
2010: Motohiro Nishida; Kenta Watanabe; Michio Nakaya; Hitoshi Kurose
[Mechanism of cardiac hypertrophy via diacylglycerol-sensitive TRPC channels].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2010;130(3):295-302.
2010: Célia Guilini; Kyoji Urayama; Gulen Turkeri; Deniz B Dedeoglu; Hitoshi Kurose; Nadia Messaddeq; Canan G Nebigil
Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration.
American journal of physiology. Heart and circulatory physiology 2010;298(3):H844-52.
2008: Motohiro Nishida; Yoji Sato; Aya Uemura; Yusuke Narita; Hidetoshi Tozaki-Saitoh; Michio Nakaya; Tomomi Ide; Kazuhiro Suzuki; Kazuhide Inoue; Taku Nagao; Hitoshi Kurose
P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis.
The EMBO journal 2008;27(23):3104-15.
2008: Motohiro Nishida; Hitoshi Kurose
Roles of TRP channels in the development of cardiac hypertrophy.
Naunyn-Schmiedeberg's archives of pharmacology 2008;378(4):395-406.
2007: Hitoshi Kurose; Motohiro Nishida
[TRPC channels and cardiac hypertrophy].
Seikagaku. The Journal of Japanese Biochemical Society 2007;79(10):953-6.
2007: Kyoji Urayama; Célia Guilini; Nadia Messaddeq; Kai Hu; Marja Steenman; Hitoshi Kurose; Georg Ert; Canan G Nebigil
The prokineticin receptor-1 (GPR73) promotes cardiomyocyte survival and angiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2980-93.
2007: Motohiro Nishida; Naoya Onohara; Yoji Sato; Reiko Suda; Mariko Ogushi; Shihori Tanabe; Ryuji Inoue; Yasuo Mori; Hitoshi Kurose
Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation.
The Journal of biological chemistry 2007;282(32):23117-28.
2006: Naoya Onohara; Motohiro Nishida; Ryuji Inoue; Hiroyuki Kobayashi; Hideki Sumimoto; Yoji Sato; Yasuo Mori; Taku Nagao; Hitoshi Kurose
TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy.
The EMBO journal 2006;25(22):5305-16.
2006: Supachoke Mangmool; Tatsuya Haga; Hiroyuki Kobayashi; Kyeong-Man Kim; Hiroyasu Nakata; Motohiro Nishida; Hitoshi Kurose
Clathrin required for phosphorylation and internalization of beta2-adrenergic receptor by G protein-coupled receptor kinase 2 (GRK2).
The Journal of biological chemistry 2006;281(42):31940-9.
2006: Yuichi Nagamatsu; Motohiro Nishida; Naoya Onohara; Masashi Fukutomi; Yoshiko Maruyama; Hiroyuki Kobayashi; Yoji Sato; Hitoshi Kurose
Heterotrimeric G protein G alpha13-induced induction of cytokine mRNAs through two distinct pathways in cardiac fibroblasts.
Journal of pharmacological sciences 2006;101(2):144-50.
2005: Hiroyuki Kobayashi; Yusuke Narita; Motohiro Nishida; Hitoshi Kurose
Beta-arrestin2 enhances beta2-adrenergic receptor-mediated nuclear translocation of ERK.
Cellular signalling 2005;17(10):1248-53.
2005: Tomomi Fujii; Naoya Onohara; Yoshiko Maruyama; Shihori Tanabe; Hiroyuki Kobayashi; Masashi Fukutomi; Yuichi Nagamatsu; Naoki Nishihara; Ryuji Inoue; Hideki Sumimoto; Futoshi Shibasaki; Taku Nagao; Motohiro Nishida; Hitoshi Kurose
Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts.
The Journal of biological chemistry 2005;280(24):23041-7.
2005: Masashi Fukutomi; Motohiro Nishida; Yoshiko Maruyama; Hiroyuki Kobayashi; Hitoshi Kurose
Caveolae-independent activation of protein kinase A in rat neonatal myocytes.
Journal of pharmacological sciences 2005;98(2):168-74.
2005: Motohiro Nishida; Shihori Tanabe; Yoshiko Maruyama; Supachoke Mangmool; Kyoji Urayama; Yuichi Nagamatsu; Shuichi Takagahara; Justin H Turner; Tohru Kozasa; Hiroyuki Kobayashi; Yoji Sato; Toru Kawanishi; Ryuji Inoue; Taku Nagao; Hitoshi Kurose
G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes.
The Journal of biological chemistry 2005;280(18):18434-41.
2003: Hitoshi Kurose
Galpha12 and Galpha13 as key regulatory mediator in signal transduction.
Life sciences 2003;74(2-3):155-61.
2003: Keiichiro Tashiro; Taku Nagao; Hitoshi Kurose; Hidenori Ichijo; Tetsuro Urushidani
Role of Rho in rabbit parietal cell.
Journal of cellular physiology 2003;197(3):409-17.
2003: Hitoshi Kurose
[Adrenergic receptor signaling and regulation].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122 Suppl():8P-10P.
2003: Ken Arai; Yoshiko Maruyama; Motohiro Nishida; Shihori Tanabe; Shuichi Takagahara; Tohru Kozasa; Yasuo Mori; Taku Nagao; Hitoshi Kurose
Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation.
Molecular pharmacology 2003;63(3):478-88.
2002: Yoshiko Maruyama; Motohiro Nishida; Yoshiyuki Sugimoto; Shihori Tanabe; Justin H Turner; Tohru Kozasa; Teiji Wada; Taku Nagao; Hitoshi Kurose
Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy.
Circulation research 2002;91(10):961-9.
2002: Yoshiyuki Sugimoto; Reiko Fujisawa; Ryuji Tanimura; Anne-Laure Lattion; Susanna Cotecchia; Gozoh Tsujimoto; Taku Nagao; Hitoshi Kurose
Beta(1)-selective agonist (-)-1-(3,4-dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [(-)-RO363] differentially interacts with key amino acids responsible for beta(1)-selective binding in resting and active states.
The Journal of pharmacology and experimental therapeutics 2002;301(1):51-8.
2002: Motohiro Nishida; Kevin L Schey; Shuichi Takagahara; Kenji Kontani; Toshiaki Katada; Yasuteru Urano; Tetsuo Nagano; Taku Nagao; Hitoshi Kurose
Activation mechanism of Gi and Go by reactive oxygen species.
The Journal of biological chemistry 2002;277(11):9036-42.
2002: Motohiro Nishida; Shuichi Takagahara; Yoshiko Maruyama; Yoshiyuki Sugimoto; Taku Nagao; Hitoshi Kurose
G beta gamma counteracts G alpha(q) signaling upon alpha(1)-adrenergic receptor stimulation.
Biochemical and biophysical research communications 2002;291(4):995-1000.
2002: Masafumi Isogaya; Taku Nagao; Hitoshi Kurose
Enhanced cAMP response of naturally occurring mutant of human beta3-adrenergic receptor.
Japanese journal of pharmacology 2002;88(3):314-8.
2002: Hitoshi Kurose
[Signal transduction and drug development].
Nihon rinsho. Japanese journal of clinical medicine 2002;60(1):25-30.
2001: T Shiina; K i Arai; Ken Arai; Norihiro Yoshida; Tatsuya Haga; Taku Nagao; Hitoshi Kurose
Clathrin box in G protein-coupled receptor kinase 2.
The Journal of biological chemistry 2001;276(35):33019-26.
2001: Hitoshi Kurose
[Reactive oxygen species and G proteins].
Seikagaku. The Journal of Japanese Biochemical Society 2001;73(7):553-6.
2001: T Shiina; Taku Nagao; Hitoshi Kurose
Low affinity of beta1-adrenergic receptor for beta-arrestins explains the resistance to agonist-induced internalization.
Life sciences 2001;68(19-20):2251-7.
2000: Y Maruyama; Taku Nagao; Hitoshi Kurose
[Simplified method for gene transfer and expression by recombinant adenoviruses].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2000;116(6):359-70.
2000: Motohiro Nishida; Yoshiko Maruyama; R Tanaka; Kenji Kontani; Taku Nagao; Hitoshi Kurose
G alpha(i) and G alpha(o) are target proteins of reactive oxygen species.
Nature 2000;408(6811):492-5.
2000: T Shiina; A Kawasaki; Taku Nagao; Hitoshi Kurose
Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors.
The Journal of biological chemistry 2000;275(37):29082-90.
1999: Masafumi Isogaya; Yoshiyuki Sugimoto; R Tanimura; R Tanaka; Hideo Kikkawa; Taku Nagao; Hitoshi Kurose
Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists.
Molecular pharmacology 1999;56(5):875-85.
1999: Hitoshi Kurose; M Nishida; Taku Nagao
[beta gamma subunit of heterotrimeric G protein as a new target molecule for drug development].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():75P-80P.
1999: A Takesono; J Zahner; K J Blumer; Taku Nagao; Hitoshi Kurose
Negative regulation of alpha2-adrenergic receptor-mediated Gi signalling by a novel pathway.
The Biochemical journal 1999;343 Pt 1():77-85.
1999: Chiyuki Akiyama; Taku Nagao; Hitoshi Kurose
Analysis of domain responsible for desensitization of beta1-adrenergic receptor.
Japanese journal of pharmacology 1999;81(1):12-20.
1999: T Sato; H Kobayashi; Taku Nagao; Hitoshi Kurose
Ser203 as well as Ser204 and Ser207 in fifth transmembrane domain of the human beta2-adrenoceptor contributes to agonist binding and receptor activation.
British journal of pharmacology 1999;128(2):272-4.
1999: Motohiro Nishida; Taku Nagao; Hitoshi Kurose
Activation of Rac1 increases c-Jun NH(2)-terminal kinase activity and DNA fragmentation in a calcium-dependent manner in rat myoblast cell line H9c2.
Biochemical and biophysical research communications 1999;262(2):350-4.
1998: Hitoshi Kurose; E Takikawa; S Akahane; R Tanaka; Taku Nagao
[Functional analysis of G protein-coupled receptor kinase (beta ARK1) by intracellular immunization].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1998;112 Suppl 1():68P-72P.
1998: Masafumi Isogaya; Y Yamagiwa; S Fujita; Yoshiyuki Sugimoto; Taku Nagao; Hitoshi Kurose
Identification of a key amino acid of the beta2-adrenergic receptor for high affinity binding of salmeterol.
Molecular pharmacology 1998;54(4):616-22.
1998: Hitoshi Kurose; E Takikawa
[Production of various antibodies and single chain Fv molecule against signal-transducing proteins].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1998;112(1):59-68.
1998: Hitoshi Kurose; Masafumi Isogaya; Hideo Kikkawa; Taku Nagao
Domains of beta1 and beta2 adrenergic receptors to bind subtype selective agonists.
Life sciences 1998;62(17-18):1513-7.
1998: Hideo Kikkawa; Masafumi Isogaya; Taku Nagao; Hitoshi Kurose
The role of the seventh transmembrane region in high affinity binding of a beta 2-selective agonist TA-2005.
Molecular pharmacology 1998;53(1):128-34.
1997: Hideo Kikkawa; Hitoshi Kurose; Masafumi Isogaya; Y Sato; Taku Nagao
Differential contribution of two serine residues of wild type and constitutively active beta2-adrenoceptors to the interaction with beta2-selective agonists.
British journal of pharmacology 1997;121(6):1059-64.
1997: Y Sato; Hitoshi Kurose; Taku Nagao
Relationship between desensitization and downregulation of beta-adrenoceptors in cardiac tissues after prolonged in vivo infusion of T-0509, a beta 1-adrenoceptor agonist.
Japanese journal of pharmacology 1997;73(4):325-32.
1997: Hitoshi Kurose
[Adrenaline receptor and dopamine receptor].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(3 Suppl):316-26.
1996: Y Sato; Hitoshi Kurose; Masafumi Isogaya; Taku Nagao
Molecular characterization of pharmacological properties of T-0509 for beta-adrenoceptors.
European journal of pharmacology 1996;315(3):363-7.
1994: Hirofumi Tsuga; Kimihiko Kameyama; Tatsuya Haga; Hitoshi Kurose; Taku Nagao
Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant-negative mutant of GRK2.
The Journal of biological chemistry 1994;269(51):32522-7.
1994: Hitoshi Kurose; Taku Nagao
[Regulation of G proteins by receptors].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1994;103(6):273-84.