FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Michihiko Kuwano

Research Profile

Anatomy

Chemicals & Drugs

Physiology

Living Beings

Mouse

Disorders

Neovascularization, Pathologic

Co-author Network

Publications

TOP 3
Tomohiro Shibata; Hiroki Ureshino; Kosuke Watari; Yuichi Murakami; Mayumi Ono; Satoshi Hattori; Masayoshi Kage; Hitoshi Kan; Akihiko Kawahara; Michihiko Kuwano
Y-box Binding Protein-1 Contributes to Both HER2/ErbB2 Expression and Lapatinib Sensitivity in Human Gastric Cancer Cells.
Sayaka Ogi; Shigehiro Ohdo; Isamu Okamoto; Hideaki Fujita; Masaki Kashihara; Michihiko Kuwano; Kazuhiko Nakagawa; Kahori Sonoda; Yoshitaka Tanaka; Chizuko Yamamoto; Mayumi Ono
Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs.
Kosuke Watari; Tomohiro Shibata; Yuichi Fukunaga; Ayana Furuno; Fumihito Hosoi; Akihiko Kawahara; Michihiko Kuwano; Takashi Kuwano; Mamiyo Nakamura; Mayumi Ono
The antitumor effect of a novel angiogenesis inhibitor (an octahydronaphthalene derivative) targeting both VEGF receptor and NF-κB pathway.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Michihiko Kuwano (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Tomohiro Shibata; Hiroki Ureshino; Kosuke Watari; Yuichi Murakami; Mayumi Ono; Satoshi Hattori; Masayoshi Kage; Hitoshi Kan; Akihiko Kawahara; Michihiko Kuwano
Y-box Binding Protein-1 Contributes to Both HER2/ErbB2 Expression and Lapatinib Sensitivity in Human Gastric Cancer Cells.
Molecular cancer therapeutics 2013;12(5):737-46.
2013: Sayaka Ogi; Shigehiro Ohdo; Isamu Okamoto; Hideaki Fujita; Masaki Kashihara; Michihiko Kuwano; Kazuhiko Nakagawa; Kahori Sonoda; Yoshitaka Tanaka; Chizuko Yamamoto; Mayumi Ono
Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs.
Cancer science 2013;104(5):573-83.
2012: Kosuke Watari; Tomohiro Shibata; Yuichi Fukunaga; Ayana Furuno; Fumihito Hosoi; Akihiko Kawahara; Michihiko Kuwano; Takashi Kuwano; Mamiyo Nakamura; Mayumi Ono
The antitumor effect of a novel angiogenesis inhibitor (an octahydronaphthalene derivative) targeting both VEGF receptor and NF-κB pathway.
International journal of cancer. Journal international du cancer 2012;131(2):310-21.
2012: Koichi Azuma; Satoshi Hattori; Tomoaki Hoshino; Hiroto Izumi; Masayoshi Kage; Akihiko Kawahara; Yuichi Murakami; Kazuhiko Nakagawa; Mayumi Ono; Tomohiro Shibata; Tomoki Taira; Shinzo Takamori; Junji Tsurutani; Kosuke Watari; Takashi Yanagawa; Michihiko Kuwano
NDRG1/Cap43/Drg-1 may predict tumor angiogenesis and poor outcome in patients with lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(5):779-89.
2012: Hiroki Ureshino; Kosuke Watari; Kazuyoshi Yanagihara; Tokuzo Arao; Hiroto Izumi; Masayoshi Kage; Akihiko Kawahara; Hisafumi Kinoshita; Michihiko Kuwano; Yuichi Murakami; Kazuto Nishio; Mayumi Ono
N-myc downstream regulated gene 1 (NDRG1) promotes metastasis of human scirrhous gastric cancer cells through epithelial mesenchymal transition.
PloS one 2012;7(7):e41312.
2012: Keisuke Tabara; Tomoko Tahira; Aki Yoshinaga; Rafael Rosell; Kahori Sonoda; Hideyuki Abe; Tokuzo Arao; Koichi Azuma; Kenshi Hayashi; Masayoshi Kage; Rina Kanda; Akihiko Kawahara; Takuya Kubo; Michihiko Kuwano; Yuichi Murakami; Kazuto Nishio; Mayumi Ono
Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells.
PloS one 2012;7(7):e41017.
2012: Koichi Azuma; Satoshi Hattori; Akihiko Kawahara; Takashi Kinoshita; Michihiko Kuwano; Kazuhiko Nakagawa; Kazutaka Nakashima; Isamu Okamoto; Mayumi Ono; Tomoki Taira; Shinzo Takamori; Masayuki Takeda; Masayoshi Kage
Association of the expression of mutant epidermal growth factor receptor protein as determined with mutation-specific antibodies in non-small cell lung cancer with progression-free survival after gefitinib treatment.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(1):122-7.
2011: Jun Akiba; Masayoshi Kage; Akihiko Kawahara; Michihiko Kuwano; Yuichi Murakami; Masaki Noda; Sachiko Ogasawara; Mayumi Ono; Sakiko Sanada; Kosuke Watari; Rin Yamaguchi; Makiko Yasumoto; Takafumi Yoshida; Hirohisa Yano
N-myc downstream regulated gene1/Cap43 overexpression suppresses tumor growth by hepatic cancer cells through cell cycle arrest at the G0/G1 phase.
Cancer letters 2011;310(1):25-34.
2011: Toshifumi Fujiwara; Jun-ichi Fukushi; Keiichiro Iida; Satoshi Kamura; Mihoko Koga; Michihiko Kuwano; Yoshihiro Matsumoto; Yoshinao Oda; Seiji Okada; Yuko Okada; Mayumi Ono; Nokitaka Setsu; Kosuke Watari; Hisakata Yamada; Shunsaku Yamamoto; Yukihide Iwamoto
Macrophage infiltration predicts a poor prognosis for human ewing sarcoma.
The American journal of pathology 2011;179(3):1157-70.
2011: Abbas Fotovati; Masayoshi Kage; Kazuo Shirouzu; Hideaki Yamana; Samah Abu-Ali; Michihiko Kuwano
N-myc downstream-regulated gene 1 (NDRG1) a differentiation marker of human breast cancer.
Pathology oncology research : POR 2011;17(3):525-33.
2011: Kenji Nakano; Masatoshi Kobayashi; Kei-Ichiro Nakamura; Takeshi Nakanishi; Ryutaro Asano; Izumi Kumagai; Hideaki Tahara; Michihiko Kuwano; Justus B Cohen; Joseph C Glorioso
Mechanism of HSV infection through soluble adapter-mediated virus bridging to the EGF receptor.
Virology 2011;413(1):12-8.
2010: Chizuko Yamamoto; Yuji Basaki; Akihiko Kawahara; Kazutaka Nakashima; Masayoshi Kage; Hiroto Izumi; Kimitoshi Kohno; Hidetaka Uramoto; Kosei Yasumoto; Michihiko Kuwano; Mayumi Ono
Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations.
Cancer research 2010;70(21):8715-25.
2010: Akihiko Kawahara; Satoshi Hattori; Jun Akiba; Kazutaka Nakashima; Tomoki Taira; Kosuke Watari; Fumihito Hosoi; Manami Uba; Yuji Basaki; Kikuo Koufuji; Kazuo Shirouzu; Shin-Ichi Akiyama; Michihiko Kuwano; Masayoshi Kage; Mayumi Ono
Infiltration of thymidine phosphorylase-positive macrophages is closely associated with tumor angiogenesis and survival in intestinal type gastric cancer.
Oncology reports 2010;24(2):405-15.
2010: Akihiko Kawahara; Koichi Azuma; Satoshi Hattori; Kazutaka Nakashima; Yuji Basaki; Jun Akiba; Sinzo Takamori; Hisamichi Aizawa; Takashi Yanagawa; Hiroto Izumi; Kimitoshi Kohno; Suminori Kono; Masayoshi Kage; Michihiko Kuwano; Mayumi Ono
The close correlation between 8-hydroxy-2'-deoxyguanosine and epidermal growth factor receptor activating mutation in non-small cell lung cancer.
Human pathology 2010;41(7):951-9.
2010: Akihiko Kawahara; Chizuko Yamamoto; Kazutaka Nakashima; Koichi Azuma; Satoshi Hattori; Masaki Kashihara; Hisamichi Aizawa; Yuji Basaki; Michihiko Kuwano; Masayoshi Kage; Tetsuya Mitsudomi; Mayumi Ono
Molecular diagnosis of activating EGFR mutations in non-small cell lung cancer using mutation-specific antibodies for immunohistochemical analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(12):3163-70.
2010: Gen Hirano; Hiroto Izumi; Akihiko Kidani; Yoshihiro Yasuniwa; Bin Han; Hitoshi Kusaba; Koichi Akashi; Michihiko Kuwano; Kimitoshi Kohno
Enhanced expression of PCAF endows apoptosis resistance in cisplatin-resistant cells.
Molecular cancer research : MCR 2010;8(6):864-72.
2010: Yuichi Murakami; Fumihito Hosoi; Hiroto Izumi; Yuichiro Maruyama; Hiroki Ureshino; Kosuke Watari; Kimitoshi Kohno; Michihiko Kuwano; Mayumi Ono
Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells.
Biochemical and biophysical research communications 2010;396(2):376-81.
2010: Yuji Basaki; Ken-Ichi Taguchi; Hiroto Izumi; Yuichi Murakami; Takuya Kubo; Fumihito Hosoi; Kosuke Watari; Kenji Nakano; Hidetoshi Kawaguchi; Shinji Ohno; Kimitoshi Kohno; Mayumi Ono; Michihiko Kuwano
Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells.
European journal of cancer (Oxford, England : 1990) 2010;46(5):954-65.
2010: YooHyun Song; Yoshinao Oda; Mikifumi Hori; Kentaro Kuroiwa; Mayumi Ono; Fumihito Hosoi; Yuji Basaki; Shoji Tokunaga; Michihiko Kuwano; Seiji Naito; Masazumi Tsuneyoshi
N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin.
Human pathology 2010;41(2):214-22.
2009: Akihiko Kidani; Hiroto Izumi; Yoichiro Yoshida; Eiji Kashiwagi; Haruki Ohmori; Tsuneo Tanaka; Michihiko Kuwano; Kimitoshi Kohno
Thioredoxin2 enhances the damaged DNA binding activity of mtTFA through direct interaction.
International journal of oncology 2009;35(6):1435-40.
2009: Masaki Kashihara; Koichi Azuma; Akihiko Kawahara; Yuji Basaki; Satoshi Hattori; Takashi Yanagawa; Yasuhiro Terazaki; Shinzo Takamori; Kazuo Shirouzu; Hisamichi Aizawa; Kenji Nakano; Masayoshi Kage; Michihiko Kuwano; Mayumi Ono
Nuclear Y-box binding protein-1, a predictive marker of prognosis, is correlated with expression of HER2/ErbB2 and HER3/ErbB3 in non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009;4(9):1066-74.
2009: Koichi Azuma; Tetsuro Sasada; Akihiko Kawahara; Satoshi Hattori; Takashi Kinoshita; Shinzo Takamori; Masao Ichiki; Youhei Imamura; Jiro Ikeda; Masayoshi Kage; Michihiko Kuwano; Hisamichi Aizawa
Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with a combination of cisplatin/docetaxel and concurrent thoracic irradiation.
Cancer chemotherapy and pharmacology 2009;64(3):565-73.
2009: Fumihito Hosoi; Hiroto Izumi; Akihiko Kawahara; Yuichi Murakami; Hisafumi Kinoshita; Masayoshi Kage; Kazuto Nishio; Kimitoshi Kohno; Michihiko Kuwano; Mayumi Ono
N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression.
Cancer research 2009;69(12):4983-91.
2009: Koichi Azuma; Tetsuro Sasada; Akihiko Kawahara; Shinzo Takamori; Satoshi Hattori; Jiro Ikeda; Kyogo Itoh; Akira Yamada; Masayoshi Kage; Michihiko Kuwano; Hisamichi Aizawa
Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with carboplatin and paclitaxel.
Lung cancer (Amsterdam, Netherlands) 2009;64(3):326-33.
2008: Kosuke Watari; Shintaro Nakao; Abbas Fotovati; Yuji Basaki; Fumihito Hosoi; Bíborka Bereczky; Ryuichi Higuchi; Tomofumi Miyamoto; Michihiko Kuwano; Mayumi Ono
Role of macrophages in inflammatory lymphangiogenesis: Enhanced production of vascular endothelial growth factor C and D through NF-kappaB activation.
Biochemical and biophysical research communications 2008;377(3):826-31.
2008: Jun Akiba; Sachiko Ogasawara; Akihiko Kawahara; Naoyo Nishida; Sakiko Sanada; Fukuko Moriya; Michihiko Kuwano; Osamu Nakashima; Hirohisa Yano
N-myc downstream regulated gene 1 (NDRG1)/Cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma.
Oncology reports 2008;20(6):1329-35.
2008: Hong-Ye Zhao; Akio Ooyama; Masatatsu Yamamoto; Ryuji Ikeda; Misako Haraguchi; Sho Tabata; Tatsuhiko Furukawa; Xiao-Fang Che; Ken-ichi Iwashita; Toshinori Oka; Masakazu Fukushima; Masayuki Nakagawa; Mayumi Ono; Michihiko Kuwano; Shin-ichi Akiyama
Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells.
Cancer letters 2008;270(1):156-63.
2008: Masaki Shiota; Hiroto Izumi; Naoya Miyamoto; Takamitsu Onitsuka; Eiji Kashiwagi; Akihiko Kidani; General Hirano; Mayu Takahashi; Mayumi Ono; Michihiko Kuwano; Seiji Naito; Yasuyuki Sasaguri; Kimitoshi Kohno
Ets regulates peroxiredoxin1 and 5 expressions through their interaction with the high-mobility group protein B1.
Cancer science 2008;99(10):1950-9.
2008: Fukuko Moriya; Sachiko Ogasawara; Yuji Basaki; Jun Akiba; Sakiko Kojiro; Suguru Fukahori; Hironori Ishizaki; Naoyo Nishida; Kei Matsuoka; Masamichi Kojiro; Michihiko Kuwano; Hirohisa Yano
Growth inhibitory effects of pegylated IFN-alpha2b and 5-fluorouracil in combination on renal cell carcinoma cell lines in vitro and in vivo.
International journal of oncology 2008;33(4):647-55.
2008: Hong-Ye Zhao; Akio Ooyama; Masatatsu Yamamoto; Ryuji Ikeda; Misako Haraguchi; Sho Tabata; Tatsuhiko Furukawa; Xiao-Fang Che; Shaoxuan Zhang; Toshinori Oka; Masakazu Fukushima; Masayuki Nakagawa; Mayumi Ono; Michihiko Kuwano; Shin-ichi Akiyama
Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil.
Cancer research 2008;68(17):7035-41.
2008: Koji Hiraoka; Michihisa Zenmyo; Kousuke Watari; Haruo Iguchi; Abbas Fotovati; Yusuke N Kimura; Fumihito Hosoi; Takanori Shoda; Kensei Nagata; Hiroyuki Osada; Mayumi Ono; Michihiko Kuwano
Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages.
Cancer science 2008;99(8):1595-602.
2008: Toshiro Migita; Yoshinao Oda; Katsuaki Masuda; Akira Hirata; Michihiko Kuwano; Seiji Naito; Masazumi Tsuneyoshi
Inverse relationship between E-cadherin and p27Kip1 expression in renal cell carcinoma.
International journal of oncology 2008;33(1):41-7.
2008: Shin Nishio; Kimio Ushijima; Naotake Tsuda; Shuji Takemoto; Kouichiro Kawano; Tomohiko Yamaguchi; Naoyo Nishida; Tatsuyuki Kakuma; Hitoshi Tsuda; Takahiro Kasamatsu; Yuko Sasajima; Masayoshi Kage; Michihiko Kuwano; Toshiharu Kamura
Cap43/NDRG1/Drg-1 is a molecular target for angiogenesis and a prognostic indicator in cervical adenocarcinoma.
Cancer letters 2008;264(1):36-43.
2008: Yoshinao Oda; Kenichi Kohashi; Hidetaka Yamamoto; Sadafumi Tamiya; Kimitoshi Kohno; Michihiko Kuwano; Yukihide Iwamoto; Tatsuro Tajiri; Tomoaki Taguchi; Masazumi Tsuneyoshi
Different expression profiles of Y-box-binding protein-1 and multidrug resistance-associated proteins between alveolar and embryonal rhabdomyosarcoma.
Cancer science 2008;99(4):726-32.
2008: Teruhiko Fujii; Akihiko Kawahara; Yuji Basaki; Satoshi Hattori; Kazutaka Nakashima; Kenji Nakano; Kazuo Shirouzu; Kimitoshi Kohno; Takashi Yanagawa; Hideaki Yamana; Kazuto Nishio; Mayumi Ono; Michihiko Kuwano; Masayoshi Kage
Expression of HER2 and estrogen receptor alpha depends upon nuclear localization of Y-box binding protein-1 in human breast cancers.
Cancer research 2008;68(5):1504-12.
2008: Teruhiko Fujii; Goro Yokoyama; Hiroki Takahashi; Roka Namoto; Shino Nakagawa; Uhi Toh; Masayoshi Kage; Kazuo Shirouzu; Michihiko Kuwano
Preclinical studies of molecular-targeting diagnostic and therapeutic strategies against breast cancer.
Breast cancer (Tokyo, Japan) 2008;15(1):73-8.
2007: Yusuke N Kimura; Kosuke Watari; Abbas Fotovati; Fumihito Hosoi; Kosei Yasumoto; Hiroto Izumi; Kimitoshi Kohno; Kazuo Umezawa; Haruo Iguchi; Kazuo Shirouzu; Sinzo Takamori; Michihiko Kuwano; Mayumi Ono
Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis.
Cancer science 2007;98(12):2009-18.
2007: Suguru Fukahori; Hirohisa Yano; Makoto Tsuneoka; Yoshiaki Tanaka; Minoru Yagi; Michihiko Kuwano; Tatsuro Tajiri; Tomoaki Taguchi; Masazumi Tsuneyoshi; Masamichi Kojiro
Immunohistochemical expressions of Cap43 and Mina53 proteins in neuroblastoma.
Journal of pediatric surgery 2007;42(11):1831-40.
2007: Masamune Nakagawa; Yoshinao Oda; Takashi Eguchi; Shinichi Aishima; Takashi Yao; Fumihito Hosoi; Yuji Basaki; Mayumi Ono; Michihiko Kuwano; Masao Tanaka; Masazumi Tsuneyoshi
Expression profile of class I histone deacetylases in human cancer tissues.
Oncology reports 2007;18(4):769-74.
2007: Shintaro Nakao; Yasuaki Hata; Muneki Miura; Kousuke Noda; Yusuke N Kimura; Shuhei Kawahara; Takeshi Kita; Toshio Hisatomi; Toru Nakazawa; Yiping Jin; M Reza Dana; Michihiko Kuwano; Mayumi Ono; Tatsuro Ishibashi; Ali Hafezi-Moghadam
Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis.
The American journal of pathology 2007;171(3):1058-65.
2007: Shinji Oie; Mayumi Ono; Hiroto Fukushima; Fumihito Hosoi; Hirohisa Yano; Yuichiro Maruyama; Masamichi Kojiro; Tadafumi Terada; Kazuyuki Hirano; Michihiko Kuwano; Yuji Yamada
Alteration of dihydropyrimidine dehydrogenase expression by IFN-alpha affects the antiproliferative effects of 5-fluorouracil in human hepatocellular carcinoma cells.
Molecular cancer therapeutics 2007;6(8):2310-8.
2007: Yoshinao Oda; Yoshihiro Ohishi; Yuji Basaki; Hiroaki Kobayashi; Toshio Hirakawa; Norio Wake; Mayumi Ono; Kazuto Nishio; Michihiko Kuwano; Masazumi Tsuneyoshi
Prognostic implications of the nuclear localization of Y-box-binding protein-1 and CXCR4 expression in ovarian cancer: their correlation with activated Akt, LRP/MVP and P-glycoprotein expression.
Cancer science 2007;98(7):1020-6.
2007: Yoshihiro Ohishi; Yoshinao Oda; Yuji Basaki; Hiroaki Kobayashi; Norio Wake; Michihiko Kuwano; Masazumi Tsuneyoshi
Expression of beta-tubulin isotypes in human primary ovarian carcinoma.
Gynecologic oncology 2007;105(3):586-92.
2007: Yuji Basaki; Fumihito Hosoi; Yoshinao Oda; Abbas Fotovati; Yuichiro Maruyama; Shinji Oie; Mayumi Ono; Hiroto Izumi; Kimitoshi Kohno; K Sakai; T Shimoyama; K Nishio; Michihiko Kuwano
Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells.
Oncogene 2007;26(19):2736-46.
2007: Hirohisa Yano; Yuji Basaki; Shinji Oie; Sachiko Ogasawara; Seiya Momosaki; Jun Akiba; Naoyo Nishida; Sakiko Kojiro; Hironori Ishizaki; Fukuko Moriya; Keitaro Kuratomi; Suguru Fukahori; Michihiko Kuwano; Masamichi Kojiro
Effects of IFN-alpha on alpha-fetoprotein expressions in hepatocellular carcinoma cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(3):231-8.
2006: Takeshi Uchiumi; Abbas Fotovati; Takakazu Sasaguri; Kohtaro Shibahara; Tatsuo Shimada; Takao Fukuda; Takanori Nakamura; Hiroto Izumi; Teruhisa Tsuzuki; Michihiko Kuwano; Kimitoshi Kohno
YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation.
The Journal of biological chemistry 2006;281(52):40440-9.
2006: Mayumi Ono; Michihiko Kuwano
Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(24):7242-51.
2006: Shinji Oie; Mayumi Ono; Hirohisa Yano; Yuichiro Maruyama; Tadafumi Terada; Yuji Yamada; Takato Ueno; Masamichi Kojiro; Kazuyuki Hirano; Michihiko Kuwano
The up-regulation of type I interferon receptor gene plays a key role in hepatocellular carcinoma cells in the synergistic antiproliferative effect by 5-fluorouracil and interferon-alpha.
International journal of oncology 2006;29(6):1469-78.
2006: Fumiaki Yamashita; Hisakazu Ohtani; Noriko Koyabu; Fumihiko Ushigome; Hiroki Satoh; Hideyasu Murakami; Takeshi Uchiumi; Takanori Nakamura; Michihiko Kuwano; Masayuki Tsujimoto; Yasufumi Sawada
Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.
The Journal of pharmacy and pharmacology 2006;58(11):1499-505.
2006: Shinichi Aishima; Yuji Basaki; Yoshinao Oda; Yousuke Kuroda; Yunosuke Nishihara; Kenichi Taguchi; Akinobu Taketomi; Yoshihiko Maehara; Fumihito Hosoi; Yuichiro Maruyama; Abbas Fotovati; Shinji Oie; Mayumi Ono; Takato Ueno; Michio Sata; Hirohisa Yano; Masamichi Kojiro; Michihiko Kuwano; Masazumi Tsuneyoshi
High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma.
Cancer science 2006;97(11):1182-90.
2006: Hirohisa Yano; Sachiko Ogasawara; Seiya Momosaki; Jun Akiba; Sakiko Kojiro; Suguru Fukahori; Hironori Ishizaki; Keitaro Kuratomi; Yuji Basaki; Shinji Oie; Michihiko Kuwano; Masamichi Kojiro
Growth inhibitory effects of pegylated IFN alpha-2b on human liver cancer cells in vitro and in vivo.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(8):964-75.
2006: Yuichiro Maruyama; Mayumi Ono; Akihiko Kawahara; Toshiro Yokoyama; Yuji Basaki; Masayoshi Kage; Shigeaki Aoyagi; Hisafumi Kinoshita; Michihiko Kuwano
Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesis.
Cancer research 2006;66(12):6233-42.
2006: Abbas Fotovati; Teruhiko Fujii; Miki Yamaguchi; Masayoshi Kage; Kazuo Shirouzu; Shinji Oie; Yuji Basaki; Mayumi Ono; Hideaki Yamana; Michihiko Kuwano
17Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(10):3010-8.
2006: Shu-Ichi Ueda; Yuji Basaki; Masumi Yoshie; Katsuhiro Ogawa; Shotaro Sakisaka; Michihiko Kuwano; Mayumi Ono
PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib.
Cancer research 2006;66(10):5346-53.
2006: Kenta Koike; Teruhiko Fujii; Anna M Nakamura; Goro Yokoyama; Hideaki Yamana; Michihiko Kuwano; Kazuo Shirouzu
Activation of protein kinase C delta induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase.
Thyroid : official journal of the American Thyroid Association 2006;16(4):333-41.
2005: Hisashi Nakamura; Shinzo Takamori; Teruhiko Fujii; Mayumi Ono; Hideaki Yamana; Michihiko Kuwano; Kazuo Shirouzu
Cooperative cell-growth inhibition by combination treatment with ZD1839 (Iressa) and trastuzumab (Herceptin) in non-small-cell lung cancer.
Cancer letters 2005;230(1):33-46.
2005: Shintaro Nakao; Takashi Kuwano; Chikako Tsutsumi-Miyahara; Shu-ichi Ueda; Yusuke N Kimura; Shinjiro Hamano; Koh-Hei Sonoda; Yasuo Saijo; Toshihiro Nukiwa; Robert M Strieter; Tatsuro Ishibashi; Michihiko Kuwano; Mayumi Ono
Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth.
The Journal of clinical investigation 2005;115(11):2979-91.
2005: Ryoko Sata; Hisakazu Ohtani; Masayuki Tsujimoto; Hideyasu Murakami; Noriko Koyabu; Takanori Nakamura; Takeshi Uchiumi; Michihiko Kuwano; Hideaki Nagata; Kiyomi Tsukimori; Hitoo Nakano; Yasufumi Sawada
Functional analysis of organic cation transporter 3 expressed in human placenta.
The Journal of pharmacology and experimental therapeutics 2005;315(2):888-95.
2005: Teruhiko Fujii; Anna M Nakamura; Goro Yokoyama; Miki Yamaguchi; Keiichiro Tayama; Keisuke Miwa; Uhi Toh; Daisuke Kawamura; Kazuo Shirouzu; Hideaki Yamana; Michihiko Kuwano; Hideaki Tsuda
Antineoplaston induces G(1) arrest by PKCalpha and MAPK pathway in SKBR-3 breast cancer cells.
Oncology reports 2005;14(2):489-94.
2005: Akira Hirata; Fumihito Hosoi; Miho Miyagawa; Shu-ichi Ueda; Seiji Naito; Teruhiko Fujii; Michihiko Kuwano; Mayumi Ono
HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells.
Cancer research 2005;65(10):4253-60.
2005: Yoshinao Oda; Tsuyoshi Saito; Naomi Tateishi; Yoshihiro Ohishi; Sadafumi Tamiya; Hidetaka Yamamoto; Ryohei Yokoyama; Takeshi Uchiumi; Yukihide Iwamoto; Michihiko Kuwano; Masazumi Tsuneyoshi
ATP-binding cassette superfamily transporter gene expression in human soft tissue sarcomas.
International journal of cancer. Journal international du cancer 2005;114(6):854-62.
2005: Goro Yokoyama; Teruhiko Fujii; Keiichiro Tayama; Hideaki Yamana; Michihiko Kuwano; Kazuo Shirouzu
PKCdelta and MAPK mediate G(1) arrest induced by PMA in SKBR-3 breast cancer cells.
Biochemical and biophysical research communications 2005;327(3):720-6.
2005: Motomu Watanabe; Yayoi Fujioka-Kaneko; Hisayuki Kobayashi; Mamoru Kiniwa; Michihiko Kuwano; Yuji Basaki
Involvement of integrin-linked kinase in capillary/tube-like network formation of human vascular endothelial cells.
Biological procedures online 2005;7():41-7.
2005: Takayuki Torigoe; Hiroto Izumi; Hiroshi Ishiguchi; Yoichiro Yoshida; Mizuho Tanabe; Takeshi Yoshida; Tomonori Igarashi; Ichiro Niina; Tetsuro Wakasugi; Takuya Imaizumi; Yasutomo Momii; Michihiko Kuwano; Kimitoshi Kohno
Cisplatin resistance and transcription factors.
Current medicinal chemistry. Anti-cancer agents 2005;5(1):15-27.
2004: Yoko Honda; Fumihiko Ushigome; Noriko Koyabu; Satoshi Morimoto; Yukihiro Shoyama; Takeshi Uchiumi; Michihiko Kuwano; Hisakazu Ohtani; Yasufumi Sawada
Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.
British journal of pharmacology 2004;143(7):856-64.
2004: Michihiko Kuwano; Yoshinao Oda; Hiroto Izumi; Song-Ju Yang; Takeshi Uchiumi; Yukihide Iwamoto; Masakazu Toi; Teruhiko Fujii; Hideaki Yamana; Hisafumi Kinoshita; Toshiharu Kamura; Masazumi Tsuneyoshi; Kosei Yasumoto; Kimitoshi Kohno
The role of nuclear Y-box binding protein 1 as a global marker in drug resistance.
Molecular cancer therapeutics 2004;3(11):1485-92.
2004: Kazuho Hirata; Katsuaki Masuda; Wataru Morikawa; Jian-Wen He; Akio Kuraoka; Michihiko Kuwano; Masaru Kawabuchi
N-myc downstream-regulated gene 1 expression in injured sciatic nerves.
Glia 2004;47(4):325-34.
2004: Michihiko Kuwano; Teruhiko Fujii; Mayumi Ono; Hiroto Izumi; Kimitoshi Kohno
[Molecular targeting drugs--present status and future development].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(7):1211-5.
2004: Akira Hirata; Hisanori Uehara; Keisuke Izumi; Seiji Naito; Michihiko Kuwano; Mayumi Ono
Direct inhibition of EGF receptor activation in vascular endothelial cells by gefitinib ('Iressa', ZD1839).
Cancer science 2004;95(7):614-8.
2004: Keiji Hisaeda; Akira Inokuchi; Takanori Nakamura; Yukihide Iwamoto; Kimitoshi Kohno; Michihiko Kuwano; Takeshi Uchiumi
Interleukin-1beta represses MRP2 gene expression through inactivation of interferon regulatory factor 3 in HepG2 cells.
Hepatology (Baltimore, Md.) 2004;39(6):1574-82.
2004: Mayumi Ono; Akira Hirata; Takuro Kometani; Miho Miyagawa; Shu-ichi Ueda; Hisafumi Kinoshita; Teruhiko Fujii; Michihiko Kuwano
Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation.
Molecular cancer therapeutics 2004;3(4):465-72.
2004: Kotaro Shibahara; Takeshi Uchiumi; Takao Fukuda; Shinobu Kura; Yohei Tominaga; Yoshihiko Maehara; Kimitoshi Kohno; Yusaku Nakabeppu; Teruhisa Tsuzuki; Michihiko Kuwano
Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C.
Cancer science 2004;95(4):348-53.
2004: Takashi Kuwano; Shintaro Nakao; Hidetaka Yamamoto; Masazumi Tsuneyoshi; Tomoya Yamamoto; Michihiko Kuwano; Mayumi Ono
Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):300-10.
2004: Takao Fukuda; Megumi Ashizuka; Takanori Nakamura; Kotaro Shibahara; Katsumasa Maeda; Hiroto Izumi; Kimitoshi Kohno; Michihiko Kuwano; Takeshi Uchiumi
Characterization of the 5'-untranslated region of YB-1 mRNA and autoregulation of translation by YB-1 protein.
Nucleic acids research 2004;32(2):611-22.
2003: Shuichi Taniguchi; Yasushi Mochida; Takeshi Uchiumi; Tomoko Tahira; Kenshi Hayashi; Koichi Takagi; Mitsuo Shimada; Yoshihiko Maehara; Hiroyuki Kuwano; Suminori Kono; Hitoo Nakano; Michihiko Kuwano; Morimasa Wada
Genetic polymorphism at the 5' regulatory region of multidrug resistance 1 (MDR1) and its association with interindividual variation of expression level in the colon.
Molecular cancer therapeutics 2003;2(12):1351-9.
2003: Sei-Joon Jeong; Ryuichi Higuchi; Mayumi Ono; Michihiko Kuwano; Youn-Chul Kim; Tomofumi Miyamoto
cis-hinokiresinol, a norlignan from Anemarrhena asphodeloides, inhibits angiogenic response in vitro and in vivo.
Biological & pharmaceutical bulletin 2003;26(12):1721-4.
2003: M Nagashige; Fumihiko Ushigome; Noriko Koyabu; K Hirata; Masaru Kawabuchi; Toshio Hirakawa; Shoji Satoh; Kiyomi Tsukimori; Hitoo Nakano; Takeshi Uchiumi; Michihiko Kuwano; Hisakazu Ohtani; Yasufumi Sawada
Basal membrane localization of MRP1 in human placental trophoblast.
Placenta 2003;24(10):951-8.
2003: Yoshinobu Wakisaka; Akiko Furuta; Katsuaki Masuda; Wataru Morikawa; Michihiko Kuwano; Toru Iwaki
Cellular distribution of NDRG1 protein in the rat kidney and brain during normal postnatal development.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003;51(11):1515-25.
2003: Katsuaki Masuda; Mayumi Ono; Masahiro Okamoto; Wataru Morikawa; Michihiro Otsubo; Toshiro Migita; Masazumi Tsuneyoshi; Heiwa Okuda; Taro Shuin; Seiji Naito; Michihiko Kuwano
Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells.
International journal of cancer. Journal international du cancer 2003;105(6):803-10.
2003: Kimitoshi Kohno; Hiroto Izumi; Takeshi Uchiumi; Megumi Ashizuka; Michihiko Kuwano
The pleiotropic functions of the Y-box-binding protein, YB-1.
BioEssays : news and reviews in molecular, cellular and developmental biology 2003;25(7):691-8.
2003: Yasushi Mochida; Ken-ichi Taguchi; Shuichi Taniguchi; Masazumi Tsuneyoshi; Hiroyuki Kuwano; Teruhisa Tsuzuki; Michihiko Kuwano; Morimasa Wada
The role of P-glycoprotein in intestinal tumorigenesis: disruption of mdr1a suppresses polyp formation in Apc(Min/+) mice.
Carcinogenesis 2003;24(7):1219-24.
2003: Toshikazu Konno; Takuya Ebihara; Keiji Hisaeda; Takeshi Uchiumi; Takanori Nakamura; Takayuki Shirakusa; Michihiko Kuwano; Morimasa Wada
Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2.
The Journal of biological chemistry 2003;278(25):22908-17.
2003: Sei-Joon Jeong; Masanori Inagaki; Ryuichi Higuchi; Tomofumi Miyamoto; Mayumi Ono; Michihiko Kuwano; Rob W M van Soest
1,3-dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis.
Chemical & pharmaceutical bulletin 2003;51(6):731-3.
2003: Shintaro Nakao; Takashi Kuwano; Tatsuro Ishibashi; Michihiko Kuwano; Mayumi Ono
Synergistic effect of TNF-alpha in soluble VCAM-1-induced angiogenesis through alpha 4 integrins.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5704-11.
2003: Yoshinao Oda; Yoshihiro Ohishi; Tsuyoshi Saito; Eiji Hinoshita; Takeshi Uchiumi; Naoko Kinukawa; Yukihide Iwamoto; Kimitoshi Kohno; Michihiko Kuwano; Masazumi Tsuneyoshi
Nuclear expression of Y-box-binding protein-1 correlates with P-glycoprotein and topoisomerase II alpha expression, and with poor prognosis in synovial sarcoma.
The Journal of pathology 2003;199(2):251-8.
2003: Michihiko Kuwano; Takeshi Uchiumi; Hiroshi Hayakawa; Mayumi Ono; Morimasa Wada; Hiroto Izumi; Kimitoshi Kohno
The basic and clinical implications of ABC transporters, Y-box-binding protein-1 (YB-1) and angiogenesis-related factors in human malignancies.
Cancer science 2003;94(1):9-14.
2003: Fumihiko Ushigome; Noriko Koyabu; Shoji Satoh; Kiyomi Tsukimori; Hitoo Nakano; Takanori Nakamura; Takeshi Uchiumi; Michihiko Kuwano; Hisakazu Ohtani; Yasufumi Sawada
Kinetic analysis of P-glycoprotein-mediated transport by using normal human placental brush-border membrane vesicles.
Pharmaceutical research 2003;20(1):38-44.
2002: Sei-Joon Jeong; Takashi Itokawa; Masabumi Shibuya; Michihiko Kuwano; Mayumi Ono; Ryuichi Higuchi; Tomofumi Miyamoto
Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway.
Cancer letters 2002;187(1-2):129-33.
2002: Yoshihiro Ohishi; Yoshinao Oda; Takeshi Uchiumi; Hiroaki Kobayashi; Toshio Hirakawa; Shingo Miyamoto; Naoko Kinukawa; Hitoo Nakano; Michihiko Kuwano; Masazumi Tsuneyoshi
ATP-binding cassette superfamily transporter gene expression in human primary ovarian carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(12):3767-75.
2002: Hideaki Yahata; Hiroaki Kobayashi; Toshiharu Kamura; Satoshi Amada; Toshio Hirakawa; Kimitoshi Kohno; Michihiko Kuwano; Hitoo Nakano
Increased nuclear localization of transcription factor YB-1 in acquired cisplatin-resistant ovarian cancer.
Journal of cancer research and clinical oncology 2002;128(11):621-6.
2002: Kenkichi Hashimoto; Takeshi Uchiumi; Toshikazu Konno; Takuya Ebihara; Takanori Nakamura; Morimasa Wada; Shotaro Sakisaka; Fumio Maniwa; Teruo Amachi; Kazumitsu Ueda; Michihiko Kuwano
Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome.
Hepatology (Baltimore, Md.) 2002;36(5):1236-45.
2002: Hiroshi Hayakawa; Takeshi Uchiumi; Takao Fukuda; Megumi Ashizuka; Kimitoshi Kohno; Michihiko Kuwano; Mutsuo Sekiguchi
Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine.
Biochemistry 2002;41(42):12739-44.
2002: Sei-Joon Jeong; Ryuichi Higuchi; Tomofumi Miyamoto; Mayumi Ono; Michihiko Kuwano; Shunsuke F Mawatari
Bryoanthrathiophene, a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852).
Journal of natural products 2002;65(9):1344-5.
2002: Megumi Ashizuka; Takao Fukuda; Takanori Nakamura; Kanemitsu Shirasuna; Kazuhiro Iwai; Hiroto Izumi; Kimitoshi Kohno; Michihiko Kuwano; Takeshi Uchiumi
Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2.
Molecular and cellular biology 2002;22(18):6375-83.
2002: Hidetaka Uramoto; Hiroto Izumi; Tomoko Ise; Mitsuhiro Tada; Takeshi Uchiumi; Michihiko Kuwano; Kosei Yasumoto; Keiko Funa; Kimitoshi Kohno
p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression.
The Journal of biological chemistry 2002;277(35):31694-702.
2002: Mari Kakehi; Noriko Koyabu; Takanori Nakamura; Takeshi Uchiumi; Michihiko Kuwano; Hisakazu Ohtani; Yasufumi Sawada
Functional characterization of mouse cation transporter mOCT2 compared with mOCT1.
Biochemical and biophysical research communications 2002;296(3):644-50.
2002: Chika Yamamoto; Hideyasu Murakami; Noriko Koyabu; Hitomi Takanaga; Hirotami Matsuo; Takeshi Uchiumi; Michihiko Kuwano; Mikihiko Naito; Takashi Tsuruo; Hisakazu Ohtani; Yasufumi Sawada
Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier.
The Journal of pharmacy and pharmacology 2002;54(8):1055-63.
2002: Yasuhiro Tada; Morimasa Wada; Ken-Ichi Taguchi; Yasushi Mochida; Naoko Kinugawa; Masazumi Tsuneyoshi; Seiji Naito; Michihiko Kuwano
The association of death-associated protein kinase hypermethylation with early recurrence in superficial bladder cancers.
Cancer research 2002;62(14):4048-53.
2002: Satomi Kanemitsu; Kenji Ihara; Ahmed Saifddin; Takeshi Otsuka; Tsutomu Takeuchi; Junya Nagayama; Michihiko Kuwano; Toshiro Hara
A functional polymorphism in fas (CD95/APO-1) gene promoter associated with systemic lupus erythematosus.
The Journal of rheumatology 2002;29(6):1183-8.
2002: Akira Hirata; Soh-ichiro Ogawa; Takuro Kometani; Takashi Kuwano; Seiji Naito; Michihiko Kuwano; Mayumi Ono
ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase.
Cancer research 2002;62(9):2554-60.
2002: Yasuhiro Tada; Morimasa Wada; Toshiro Migita; Junya Nagayama; Eiji Hinoshita; Yasushi Mochida; Yoshihiko Maehara; Masazumi Tsuneyoshi; Michihiko Kuwano; Seiji Naito
Increased expression of multidrug resistance-associated proteins in bladder cancer during clinical course and drug resistance to doxorubicin.
International journal of cancer. Journal international du cancer 2002;98(4):630-5.
2002: Takashi Itokawa; Hiroki Nokihara; Yasuhiko Nishioka; Saburo Sone; Yukihide Iwamoto; Yuji Yamada; Julie Cherrington; Gerald McMahon; Masabumi Shibuya; Michihiko Kuwano; Mayumi Ono
Antiangiogenic effect by SU5416 is partly attributable to inhibition of Flt-1 receptor signaling.
Molecular cancer therapeutics 2002;1(5):295-302.
2002: Morimasa Wada; Shuichi Taniguchi; Takuya Ebihara; Takanori Nakamura; Takeshi Uchiumi; Michihiko Kuwano
[Genetic polymorphism of efflux drug transporters and their role in drug sensitivity].
Fukuoka igaku zasshi = Hukuoka acta medica 2002;93(3):29-37.
2002: Masahiro Okamoto; Mayumi Ono; Takeshi Uchiumi; Hikaru Ueno; Kimitoshi Kohno; Keizo Sugimachi; Michihiko Kuwano
Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor beta in human cancer cells--transcriptional activation and messenger RNA stabilization.
Biochimica et biophysica acta 2002;1574(1):24-34.
2001: Akira Inokuchi; Eiji Hinoshita; Yukihide Iwamoto; Kimitoshi Kohno; Michihiko Kuwano; Takeshi Uchiumi
Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter.
The Journal of biological chemistry 2001;276(50):46822-9.
2001: Eiji Hinoshita; Ken-ichi Taguchi; Akira Inokuchi; Takeshi Uchiumi; Naoko Kinukawa; Mitsuo Shimada; Masazumi Tsuneyoshi; Keishi Sugimachi; Michihiko Kuwano
Decreased expression of an ATP-binding cassette transporter, MRP2, in human livers with hepatitis C virus infection.
Journal of hepatology 2001;35(6):765-73.
2001: Kotaro Shibahara; Kenji Sugio; T Osaki; Takeshi Uchiumi; Yoshihiko Maehara; Kimitoshi Kohno; K Yasumoto; Keishi Sugimachi; Michihiko Kuwano
Nuclear expression of the Y-box binding protein, YB-1, as a novel marker of disease progression in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(10):3151-5.
2001: Toshiro Migita; Yoshinao Oda; Seiji Naito; Wataru Morikawa; Michihiko Kuwano; Masazumi Tsuneyoshi
The accumulation of angiostatin-like fragments in human prostate carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(9):2750-6.
2001: Hiroshi Hayakawa; Michihiko Kuwano; Mutsuo Sekiguchi
Specific binding of 8-oxoguanine-containing RNA to polynucleotide phosphorylase protein.
Biochemistry 2001;40(33):9977-82.
2001: Morimasa Wada; Takeshi Uchiumi; Michihiko Kuwano
[Novel insights on the structure and function of ABC transporters].
Seikagaku. The Journal of Japanese Biochemical Society 2001;73(7):537-46.
2001: Michihiko Kuwano; J i Fukushi; M Okamoto; Akihiro Nishie; H Goto; T Ishibashi; Mayumi Ono
Angiogenesis factors.
Internal medicine (Tokyo, Japan) 2001;40(7):565-72.
2001: Akihiro Nishie; Kouji Masuda; Michihiro Otsubo; Toshiro Migita; Masazumi Tsuneyoshi; Kimitoshi Kohno; Taro Shuin; Seiji Naito; Mayumi Ono; Michihiko Kuwano
High expression of the Cap43 gene in infiltrating macrophages of human renal cell carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):2145-51.
2001: Mayumi Ono; Michihiko Kuwano
[Tumor angiogenesis and tumor angiogenesis inhibitors].
Gan to kagaku ryoho. Cancer & chemotherapy 2001;28(5):584-90.
2001: Hiroto Izumi; T Imamura; Gunji Nagatani; Tomoko Ise; Tadashi Murakami; Hidetaka Uramoto; Takayuki Torigoe; Hiroshi Ishiguchi; Yoichiro Yoshida; Minoru Nomoto; Takashi Okamoto; Takeshi Uchiumi; Michihiko Kuwano; Keiko Funa; Kimitoshi Kohno
Y box-binding protein-1 binds preferentially to single-stranded nucleic acids and exhibits 3'-->5' exonuclease activity.
Nucleic acids research 2001;29(5):1200-7.
2001: S Haga; Eiji Hinoshita; K Ikezaki; Masashi Fukui; G L Scheffer; Takeshi Uchiumi; Michihiko Kuwano
Involvement of the multidrug resistance protein 3 in drug sensitivity and its expression in human glioma.
Japanese journal of cancer research : Gann 2001;92(2):211-9.
2001: Junya Nagayama; M Iino; Yasuhiro Tada; Hitoshi Kusaba; A Kiue; Koichi Ohshima; Michihiko Kuwano; Morimasa Wada
Retrovirus insertion and transcriptional activation of the multidrug-resistance gene in leukemias treated by a chemotherapeutic agent in vivo.
Blood 2001;97(3):759-66.
2001: S Tasaka; H Ohmori; N Gomi; M Iino; T Machida; A Kiue; Seiji Naito; Michihiko Kuwano
Synthesis and structure--activity analysis of novel dihydropyridine derivatives to overcome multidrug resistance.
Bioorganic & medicinal chemistry letters 2001;11(2):275-7.
2001: H Goto; Kimitoshi Kohno; S Sone; S Akiyama; Michihiko Kuwano; Mayumi Ono
Interferon gamma-dependent induction of thymidine phosphorylase/platelet-derived endothelial growth factor through gamma-activated sequence-like element in human macrophages.
Cancer research 2001;61(2):469-73.
2000: Takashi Okamoto; Hiroto Izumi; T Imamura; H Takano; Tomoko Ise; Takeshi Uchiumi; Michihiko Kuwano; Kimitoshi Kohno
Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression.
Oncogene 2000;19(54):6194-202.
2000: Wataru Morikawa; Kenji Yamamoto; S Ishikawa; S Takemoto; Mayumi Ono; J i Fukushi; Seiji Naito; Chikateru Nozaki; Sadaaki Iwanaga; Michihiko Kuwano
Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells.
The Journal of biological chemistry 2000;275(49):38912-20.
2000: Yasuhiro Tada; Morimasa Wada; K Kuroiwa; Naoko Kinugawa; Taishi Harada; Junya Nagayama; M Nakagawa; Seiji Naito; Michihiko Kuwano
MDR1 gene overexpression and altered degree of methylation at the promoter region in bladder cancer during chemotherapeutic treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(12):4618-27.
2000: Fumihiko Ushigome; Hitomi Takanaga; Hirotami Matsuo; S Yanai; Kiyomi Tsukimori; Hitoo Nakano; Takeshi Uchiumi; Tsuyoshi Nakamura; Michihiko Kuwano; Hisakazu Ohtani; Yasufumi Sawada
Human placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein.
European journal of pharmacology 2000;408(1):1-10.
2000: Ritsuko Umeshita-Suyama; Rie Sugimoto; Mina Akaiwa; Kazuhiko Arima; Bin Yu; M Wada; Michihiko Kuwano; K Nakajima; Naotaka Hamasaki; Kenji Izuhara
Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation.
International immunology 2000;12(11):1499-509.
2000: Seiji Naito; Hirofumi Koga; Akira Yokomizo; N Sakamoto; S Kotoh; M Nakashima; A Kiue; Michihiko Kuwano
Molecular analysis of mechanisms regulating drug sensitivity and the development of new chemotherapy strategies for genitourinary carcinomas.
World journal of surgery 2000;24(10):1183-6.
2000: Taishi Harada; Akihiro Nishie; K Torigoe; K Ikezaki; T Shono; Yoshihiko Maehara; Michihiko Kuwano; Morimasa Wada
The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene inBrain tissues and gliomas.
Japanese journal of cancer research : Gann 2000;91(10):1001-6.
2000: H Torisu-Itakura; masutaka furue; Michihiko Kuwano; Mayumi Ono
Co-expression of thymidine phosphorylase and heme oxygenase-1 in macrophages in human malignant vertical growth melanomas.
Japanese journal of cancer research : Gann 2000;91(9):906-10.
2000: J i Fukushi; Mayumi Ono; Wataru Morikawa; Yukihide Iwamoto; Michihiko Kuwano
The activity of soluble VCAM-1 in angiogenesis stimulated by IL-4 and IL-13.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2818-23.
2000: Eiji Hinoshita; Takeshi Uchiumi; Ken-ichi Taguchi; Naoko Kinukawa; Masazumi Tsuneyoshi; Yoshihiko Maehara; Keishi Sugimachi; Michihiko Kuwano
Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2401-7.
2000: T Harada; Junya Nagayama; Kimitoshi Kohno; L A Mickley; T Fojo; Michihiko Kuwano; Morimasa Wada
Alu-associated interstitial deletions and chromosomal re-arrangement in 2 human multidrug-resistant cell lines.
International journal of cancer. Journal international du cancer 2000;86(4):506-11.
2000: Hiroyuki Torisu; Mayumi Ono; Hiromaro Kiryu; masutaka furue; Y Ohmoto; Juichiro Nakayama; Y Nishioka; S Sone; Michihiko Kuwano
Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha.
International journal of cancer. Journal international du cancer 2000;85(2):182-8.
1999: Minoru Nomoto; Hiroto Izumi; Tomoko Ise; Koichi Kato; H Takano; Gunji Nagatani; Kazunori Shibao; Ryo Ohta; T Imamura; Michihiko Kuwano; Ken-ichi Matsuo; Y Yamada; Hideaki Itoh; Kimitoshi Kohno
Structural basis for the regulation of UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase-3 gene expression in adenocarcinoma cells.
Cancer research 1999;59(24):6214-22.
1999: Kazunori Shibao; H Takano; Y Nakayama; K Okazaki; Naoki Nagata; Hiroto Izumi; T Uchiumi; Michihiko Kuwano; Kimitoshi Kohno; Hideaki Itoh
Enhanced coexpression of YB-1 and DNA topoisomerase II alpha genes in human colorectal carcinomas.
International journal of cancer. Journal international du cancer 1999;83(6):732-7.
1999: Teruo Tanaka; Takeshi Uchiumi; Eiji Hinoshita; Akira Inokuchi; S Toh; Morimasa Wada; H Takano; Kimitoshi Kohno; Michihiko Kuwano
The human multidrug resistance protein 2 gene: functional characterization of the 5'-flanking region and expression in hepatic cells.
Hepatology (Baltimore, Md.) 1999;30(6):1507-12.
1999: Tomoko Ise; Hiroto Izumi; Gunji Nagatani; H Takano; M Wada; Michihiko Kuwano; Kimitoshi Kohno
Structural characterization of the human interleukin-13 receptor alpha1 gene promoter.
Biochemical and biophysical research communications 1999;265(2):387-94.
1999: T Kawabe; Zhe-Sheng Chen; Morimasa Wada; Takeshi Uchiumi; Mayumi Ono; S Akiyama; Michihiko Kuwano
Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2).
FEBS letters 1999;456(2):327-31.
1999: Hitoshi Kusaba; M Nakayama; Taishi Harada; M Nomoto; Kimitoshi Kohno; Michihiko Kuwano; Morimasa Wada
Association of 5' CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells.
European journal of biochemistry / FEBS 1999;262(3):924-32.
1999: Toshiharu Kamura; Hideaki Yahata; Satoshi Amada; Shinji Ogawa; Takanori Sonoda; Hiroaki Kobayashi; M Mitsumoto; Kimitoshi Kohno; Michihiko Kuwano; Hitoo Nakano
Is nuclear expression of Y box-binding protein-1 a new prognostic factor in ovarian serous adenocarcinoma?
Cancer 1999;85(11):2450-4.
1999: Teruo Tanaka; Takeshi Uchiumi; M Nomoto; Kimitoshi Kohno; T Kondo; K Nishio; N Saijo; Michihiko Kuwano
Cellular balance of glutathione levels through the expression of gamma-glutamylcysteine synthetase and glutathione thiol transferase genes in human hepatic cells resistant to a glutathione poison.
Biochimica et biophysica acta 1999;1427(3):367-77.
1999: Akihiro Nishie; Mayumi Ono; T Shono; J i Fukushi; Michihiro Otsubo; Hitoshi Onoue; Yushi Ito; Takanori Inamura; K Ikezaki; Masashi Fukui; Toru Iwaki; Michihiko Kuwano
Macrophage infiltration and heme oxygenase-1 expression correlate with angiogenesis in human gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(5):1107-13.
1999: Michihiko Kuwano; S Toh; Takeshi Uchiumi; H Takano; Kimitoshi Kohno; Morimasa Wada
Multidrug resistance-associated protein subfamily transporters and drug resistance.
Anti-cancer drug design 1999;14(2):123-31.
1999: H Takano; Tomoko Ise; Minoru Nomoto; Koichi Kato; Tadashi Murakami; Haruki Ohmori; T Imamura; Gunji Nagatani; Takashi Okamoto; Ryo Ohta; M Furukawa; Kazunori Shibao; Hiroto Izumi; Michihiko Kuwano; Kimitoshi Kohno
Structural and functional analysis of the control region of the human DNA topoisomerase II alpha gene in drug-resistant cells.
Anti-cancer drug design 1999;14(2):87-92.
1999: Hiroshi Hayakawa; A Hofer; L Thelander; S Kitajima; Y Cai; S Oshiro; Hiroyuki Yakushiji; Yusaku Nakabeppu; Michihiko Kuwano; Mutsuo Sekiguchi
Metabolic fate of oxidized guanine ribonucleotides in mammalian cells.
Biochemistry 1999;38(12):3610-4.
1999: J Matsuzaki; C Yamamoto; T Miyama; Hitomi Takanaga; Hirotami Matsuo; H Ishizuka; Y Kawahara; Michihiko Kuwano; M Naito; Takashi Tsuruo; Yasufumi Sawada
Contribution of P-glycoprotein to bunitrolol efflux across blood-brain barrier.
Biopharmaceutics & drug disposition 1999;20(2):85-90.
1999: S Toh; Morimasa Wada; Takeshi Uchiumi; Akira Inokuchi; Y Makino; Y Horie; Y Adachi; Shotaro Sakisaka; Michihiko Kuwano
Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome.
American journal of human genetics 1999;64(3):739-46.
1999: Tomoko Ise; Gunji Nagatani; T Imamura; Koichi Kato; H Takano; Minoru Nomoto; Hiroto Izumi; Haruki Ohmori; Takashi Okamoto; T Ohga; Takeshi Uchiumi; Michihiko Kuwano; Kimitoshi Kohno
Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen.
Cancer research 1999;59(2):342-6.
1999: S Ogawa; S Yoshida; Mayumi Ono; Hitoshi Onoue; Yushi Ito; T Ishibashi; H Inomata; Michihiko Kuwano
Induction of macrophage inflammatory protein-1alpha and vascular endothelial growth factor during inflammatory neovascularization in the mouse cornea.
Angiogenesis 1999;3(4):327-34.
1999: Mayumi Ono; Hiroyuki Torisu; J i Fukushi; Akihiro Nishie; Michihiko Kuwano
Biological implications of macrophage infiltration in human tumor angiogenesis.
Cancer chemotherapy and pharmacology 1999;43 Suppl():S69-71.
1998: M Nakayama; Morimasa Wada; Taishi Harada; Junya Nagayama; Hitoshi Kusaba; Koichi Ohshima; Mitsuo Kozuru; H Komatsu; R Ueda; Michihiko Kuwano
Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias.
Blood 1998;92(11):4296-307.
1998: N Kawahara; Mayumi Ono; Ken-ichi Taguchi; Masahiro Okamoto; Mitsuo Shimada; Kenji Takenaka; K Hayashi; D F Mosher; Keishi Sugimachi; Masazumi Tsuneyoshi; Michihiko Kuwano
Enhanced expression of thrombospondin-1 and hypovascularity in human cholangiocarcinoma.
Hepatology (Baltimore, Md.) 1998;28(6):1512-7.
1998: Takeshi Uchiumi; Eiji Hinoshita; S Haga; Tetsuya Nakamura; Teruo Tanaka; S Toh; M Furukawa; T Kawabe; Morimasa Wada; K Kagotani; K Okumura; Kimitoshi Kohno; S Akiyama; Michihiko Kuwano
Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport.
Biochemical and biophysical research communications 1998;252(1):103-10.
1998: H Tanabe; S Tasaka; H Ohmori; N Gomi; Y Sasaki; T Machida; M Iino; A Kiue; Seiji Naito; Michihiko Kuwano
Newly synthesized dihydropyridine derivatives as modulators of P-glycoprotein-mediated multidrug resistance.
Bioorganic & medicinal chemistry 1998;6(11):2219-27.
1998: J i Fukushi; Takashi Morisaki; T Shono; Akihiro Nishie; Hiroyuki Torisu; Mayumi Ono; Michihiko Kuwano
Novel biological functions of interleukin-4: formation of tube-like structures by vascular endothelial cells in vitro and angiogenesis in vivo.
Biochemical and biophysical research communications 1998;250(2):444-8.
1998: Mayumi Ono; Michihiko Kuwano
[Tumor angiogenesis].
Seikagaku. The Journal of Japanese Biochemical Society 1998;70(9):1159-70.
1998: Yoshinao Oda; Akio Sakamoto; N Shinohara; Takefumi Ohga; Takeshi Uchiumi; Kimitoshi Kohno; Masazumi Tsuneyoshi; Michihiko Kuwano; Yukihide Iwamoto
Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(9):2273-7.
1998: Teruo Tanaka; Takeshi Uchiumi; Kimitoshi Kohno; A Tomonari; K Nishio; N Saijo; T Kondo; Michihiko Kuwano
Glutathione homeostasis in human hepatic cells: overexpression of gamma-glutamylcysteine synthetase gene in cell lines resistant to buthionine sulfoximine, an inhibitor of glutathione synthesis.
Biochemical and biophysical research communications 1998;246(2):398-403.
1998: M Furukawa; Takeshi Uchiumi; M Nomoto; H Takano; R I Morimoto; Seiji Naito; Michihiko Kuwano; Kimitoshi Kohno
The role of an inverted CCAAT element in transcriptional activation of the human DNA topoisomerase IIalpha gene by heat shock.
The Journal of biological chemistry 1998;273(17):10550-5.
1998: K Torigoe; Taishi Harada; Hitoshi Kusaba; Takeshi Uchiumi; Kimitoshi Kohno; Eric Green; S W Scherer; L C Tsui; David Schlessinger; Michihiko Kuwano; Morimasa Wada
Localization of 67 exons on a YAC contig spanning 1.5 Mb around the multidrug resistance gene region of human chromosome 7q21.1.
Genomics 1998;49(1):14-22.
1998: Takefumi Ohga; Takeshi Uchiumi; Y Makino; K Koike; Morimasa Wada; Michihiko Kuwano; Kimitoshi Kohno
Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene.
The Journal of biological chemistry 1998;273(11):5997-6000.
1998: Morimasa Wada; S Toh; K Taniguchi; Tetsuya Nakamura; Takeshi Uchiumi; Kimitoshi Kohno; I Yoshida; A Kimura; Shotaro Sakisaka; Y Adachi; Michihiko Kuwano
Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome.
Human molecular genetics 1998;7(2):203-7.
1998: S Toh; Tetsuya Nakamura; Takefumi Ohga; K Koike; Takeshi Uchiumi; Morimasa Wada; Michihiko Kuwano; Kimitoshi Kohno
Genomic organization of the human Y-box protein (YB-1) gene.
Gene 1998;206(1):93-7.
1998: D Goto; H Izumi; Mayumi Ono; T Okamoto; K Kohno; Michihiko Kuwano
Tubular morphogenesis by genotoxic therapeutic agents that induce NF-kappaB activation in human vascular endothelial cells.
Angiogenesis 1998;2(4):345-56.
1998: T Shono; Masaiwa Motoyama; K Tatsumi; N Ulbrich; Y Iwamoto; Michihiko Kuwano; Mayumi Ono
A new synthetic matrix metalloproteinase inhibitor modulates both angiogenesis and urokinase type plasminogen activator activity.
Angiogenesis 1998;2(4):319-29.
1998: S Jimi; T Shono; M Tanaka; A Kono; Y Yamada; K Shudo; Michihiko Kuwano
Effect of retinoic acid on morphological changes of human pancreatic cancer cells on collagen gels: a possible association with the metastatic potentials.
Oncology research 1998;10(1):7-14.
1997: K Koike; T Kawabe; Teruo Tanaka; S Toh; Takeshi Uchiumi; Morimasa Wada; S Akiyama; Mayumi Ono; Michihiko Kuwano
A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells.
Cancer research 1997;57(24):5475-9.
1997: Shin Ushiro; K Mizoguchi; S Yoshida; S Jimi; T Fujiwara; M Yoshida; E T Wei; P Kitabgi; S Amagaya; Mayumi Ono; Michihiko Kuwano
Stimulation of cell-surface urokinase-type plasminogen activator activity and cell migration in vascular endothelial cells by a novel hexapeptide analogue of neurotensin.
FEBS letters 1997;418(3):341-5.
1997: Michihiko Kuwano
[Novel molecular targets for anticancer drugs].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(15):2187-9.
1997: K Koike; Takeshi Uchiumi; Takefumi Ohga; S Toh; Morimasa Wada; Kimitoshi Kohno; Michihiko Kuwano
Nuclear translocation of the Y-box binding protein by ultraviolet irradiation.
FEBS letters 1997;417(3):390-4.
1997: M Ryuto; S Jimi; Mayumi Ono; S Naito; Y Nakayama; Y Yamada; Sohtaro Komiyama; Michihiko Kuwano
All-trans-retinoic acid-dependent inhibition of E-cadherin-based cell adhesion with concomitant dephosphorylation of beta-catenin in metastatic human renal carcinoma cells.
Japanese journal of cancer research : Gann 1997;88(10):982-91.
1997: Mayumi Ono; Michihiko Kuwano
[Angiogenesis and its inhibitors].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(11):1585-93.
1997: Shin Ushiro; Mayumi Ono; Juichiro Nakayama; T Fujiwara; Y Komatsu; Keishi Sugimachi; Michihiko Kuwano
New nortriterpenoid isolated from anti-rheumatoid arthritic plant, Tripterygium wilfordii, modulates tumor growth and neovascularization.
International journal of cancer. Journal international du cancer 1997;72(4):657-63.
1997: Hitoshi Kusaba; M Nakayama; Taishi Harada; K Torigoe; Eric Green; S W Scherer; Kimitoshi Kohno; Michihiko Kuwano; Morimasa Wada
Maintenance of hypomethylation status and preferential expression of exogenous human MDR1/PGY1 gene in mouse L cells by YAC mediated transfer.
Somatic cell and molecular genetics 1997;23(4):259-74.
1997: S Yoshida; Mayumi Ono; T Shono; Hiroto Izumi; Tatsuro Ishibashi; H Suzuki; Michihiko Kuwano
Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis.
Molecular and cellular biology 1997;17(7):4015-23.
1997: M Furukawa; Taishi Harada; T Tanaka; Michihiko Kuwano
[DNA topoisomerases targeting anticancer agents and mechanism for acquirement of drug resistance].
Nihon rinsho. Japanese journal of clinical medicine 1997;55(5):1096-102.
1997: S Kotoh; Seiji Naito; Akira Yokomizo; Kimitoshi Kohno; Michihiko Kuwano; J Kumazawa
Enhanced expression of gamma-glutamylcysteine synthetase and glutathione S-transferase genes in cisplatin-resistant bladder cancer cells with multidrug resistance phenotype.
The Journal of urology 1997;157(3):1054-8.
1997: Mayumi Ono; Michihiko Kuwano
[Development of anti tumor agents targeting angiogenesis].
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(2):178-86.
1996: N Kawahara; Teruo Tanaka; Akira Yokomizo; H Nanri; Mayumi Ono; Morimasa Wada; Kimitoshi Kohno; K Takenaka; K Sugimachi; Michihiko Kuwano
Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin.
Cancer research 1996;56(23):5330-3.
1996: T Hisano; Mayumi Ono; M Nakayama; S Naito; Michihiko Kuwano; Morimasa Wada
Increased expression of T-plastin gene in cisplatin-resistant human cancer cells: identification by mRNA differential display.
FEBS letters 1996;397(1):101-7.
1996: M Ryuto; Mayumi Ono; H Izumi; S Yoshida; H A Weich; Kimitoshi Kohno; Michihiko Kuwano
Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1.
The Journal of biological chemistry 1996;271(45):28220-8.
1996: Y Nakayama; S Naito; M Ryuto; Y Hata; Mayumi Ono; K Sueishi; S Komiyama; H Itoh; Michihiko Kuwano
An in vitro invasion model for human renal cell carcinoma cell lines mimicking their metastatic abilities.
Clinical & experimental metastasis 1996;14(5):466-74.
1996: Takefumi Ohga; K Koike; Mayumi Ono; Y Makino; Y Itagaki; M Tanimoto; Michihiko Kuwano; Kimitoshi Kohno
Role of the human Y box-binding protein YB-1 in cellular sensitivity to the DNA-damaging agents cisplatin, mitomycin C, and ultraviolet light.
Cancer research 1996;56(18):4224-8.
1996: K Taniguchi; Morimasa Wada; Kimitoshi Kohno; T Nakamura; T Kawabe; M Kawakami; K Kagotani; Koji Okumura; S Akiyama; Michihiko Kuwano
A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.
Cancer research 1996;56(18):4124-9.
1996: K Koike; T Abe; T Hisano; T Kubo; Morimasa Wada; Kimitoshi Kohno; Michihiko Kuwano
Overexpression of multidrug resistance protein gene in human cancer cell lines selected for drug resistance to epipodophyllotoxins.
Japanese journal of cancer research : Gann 1996;87(7):765-72.
1996: Y Makino; Takefumi Ohga; S Toh; K Koike; Koji Okumura; Morimasa Wada; Michihiko Kuwano; Kimitoshi Kohno
Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter.
Nucleic acids research 1996;24(10):1873-8.
1996: K Taniguchi; Kimitoshi Kohno; K Kawanami; Morimasa Wada; T Kanematsu; Michihiko Kuwano
Drug-induced down-regulation of topoisomerase I in human epidermoid cancer cells resistant to saintopin and camptothecins.
Cancer research 1996;56(10):2348-54.
1996: T Okimoto; Kimitoshi Kohno; Michihiko Kuwano; J Gopas; H F Kung; Mayumi Ono
Regulation of epidermal growth factor receptor by activated H-ras and V-myc oncogenes in mouse Balb/3T3 cells: possible roles of AP-1.
Oncogene 1996;12(8):1625-33.
1996: Mayumi Ono; N Kawahara; D Goto; Y Wakabayashi; Shin Ushiro; S Yoshida; H Izumi; Michihiko Kuwano; Y Sato
Inhibition of tumor growth and neovascularization by an anti-gastric ulcer agent, irsogladine.
Cancer research 1996;56(7):1512-6.
1996: K Kawanami; T Nakamura; Mayumi Ono; T Kusano; K Okada; A Kikuchi; N Adachi; Kimitoshi Kohno; K Higashi; Michihiko Kuwano
Decreased DNA topoisomerase II alpha expression and cold-sensitive growth in a mouse mammary cancer cell line resistant to etoposide and doxorubicin.
Oncology research 1996;8(5):197-206.
1996: Mayumi Ono; H Izumi; S Yoshida; D Goto; S Jimi; N Kawahara; T Shono; Shin Ushiro; M Ryuto; Kimitoshi Kohno; Y Sato; Michihiko Kuwano
Angiogenesis as a new target for cancer treatment.
Cancer chemotherapy and pharmacology 1996;38 Suppl():S78-82.
1996: Shin Ushiro; Mayumi Ono; H Izumi; Kimitoshi Kohno; N Taniguchi; S Higashiyama; Michihiko Kuwano
Heparin-binding epidermal growth factor-like growth factor: p91 activation induction of plasminogen activator/inhibitor, and tubular morphogenesis in human microvascular endothelial cells.
Japanese journal of cancer research : Gann 1996;87(1):68-77.
1995: S Naito; S Hasegawa; Akira Yokomizo; Hirofumi Koga; S Kotoh; Michihiko Kuwano; J Kumazawa
Non-P-glycoprotein-mediated atypical multidrug resistance in a human bladder cancer cell line.
Japanese journal of cancer research : Gann 1995;86(11):1112-8.
1995: Hitoshi Kusaba; Kimitoshi Kohno; K Asakuno; Michihiko Kuwano; Koji Okumura; Eric Green; David Schlessinger; Morimasa Wada
Functional expression of yeast artificial chromosome-human multidrug resistance genes in mouse cells.
Genome research 1995;5(3):245-58.
1995: K Torigoe; S Sato; Hitoshi Kusaba; Kimitoshi Kohno; Michihiko Kuwano; Koji Okumura; Eric Green; L C Tsui; S W Scherer; David Schlessinger; M Wada
A YAC-based contig of 1.5 Mb spanning the human multidrug resistance gene region and delineating the amplification unit in three human multidrug-resistant cell lines.
Genome research 1995;5(3):233-44.
1995: Akira Yokomizo; Mayumi Ono; H Nanri; Y Makino; Takefumi Ohga; Morimasa Wada; Takashi Okamoto; J Yodoi; Michihiko Kuwano; Kimitoshi Kohno
Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide.
Cancer research 1995;55(19):4293-6.
1995: T Kubo; Kimitoshi Kohno; Takefumi Ohga; K Taniguchi; K Kawanami; Morimasa Wada; Michihiko Kuwano
DNA topoisomerase II alpha gene expression under transcriptional control in etoposide/teniposide-resistant human cancer cells.
Cancer research 1995;55(17):3860-4.
1995: Akira Yokomizo; Kimitoshi Kohno; Morimasa Wada; Mayumi Ono; C S Morrow; K H Cowan; Michihiko Kuwano
Markedly decreased expression of glutathione S-transferase pi gene in human cancer cell lines resistant to buthionine sulfoximine, an inhibitor of cellular glutathione synthesis.
The Journal of biological chemistry 1995;270(33):19451-7.
1995: Teruo Abe; K Koike; Takefumi Ohga; T Kubo; Morimasa Wada; Kimitoshi Kohno; T Mori; K Hidaka; Michihiko Kuwano
Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1.
British journal of cancer 1995;72(2):418-23.
1995: S Jimi; K Ito; Kimitoshi Kohno; Mayumi Ono; Michihiko Kuwano; Y Itagaki; H Ishikawa
Modulation by bovine angiogenin of tubular morphogenesis and expression of plasminogen activator in bovine endothelial cells.
Biochemical and biophysical research communications 1995;211(2):476-83.
1995: S Hasegawa; Teruo Abe; S Naito; S Kotoh; J Kumazawa; DR Hipfner; Roger G Deeley; SUSAN COLE; Michihiko Kuwano
Expression of multidrug resistance-associated protein (MRP), MDR1 and DNA topoisomerase II in human multidrug-resistant bladder cancer cell lines.
British journal of cancer 1995;71(5):907-13.
1995: K Samoto; Kiyonobu Ikezaki; Mayumi Ono; T Shono; Kimitoshi Kohno; Michihiko Kuwano; Masashi Fukui
Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors.
Cancer research 1995;55(5):1189-93.
1995: K Ito; M Ryuto; Shin Ushiro; Mayumi Ono; A Sugenoya; Akio Kuraoka; Y Shibata; Michihiko Kuwano
Expression of tissue-type plasminogen activator and its inhibitor couples with development of capillary network by human microvascular endothelial cells on Matrigel.
Journal of cellular physiology 1995;162(2):213-24.
1994: Y Nakayama; T Hisano; T Okimoto; Y Tanaka; T Ishikawa; Masaru Himeno; Mayumi Ono; Michihiko Kuwano
Microtubule reorganization and lysosome redistribution by a viral v-src oncogene, in mouse Balb/3T3 cells expressing human EGF receptor.
Cell structure and function 1994;19(6):397-409.
1994: H Izumi; Mayumi Ono; Shin Ushiro; Kimitoshi Kohno; H F Kung; Michihiko Kuwano
Cross talk of tumor necrosis factor-alpha and epidermal growth factor in human microvascular endothelial cells.
Experimental cell research 1994;214(2):654-62.
1994: T Abe; S Hasegawa; K Taniguchi; Akira Yokomizo; T Kuwano; Mayumi Ono; T Mori; S Hori; Kimitoshi Kohno; Michihiko Kuwano
Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells.
International journal of cancer. Journal international du cancer 1994;58(6):860-4.
1994: T Okuyama; Yoshihiko Maehara; K Endo; Hideo Baba; Y Adachi; Michihiko Kuwano; K Sugimachi
Expression of glutathione S-transferase-pi and sensitivity of human gastric cancer cells to cisplatin.
Cancer 1994;74(4):1230-6.
1994: Kimitoshi Kohno; H Tanimura; S Sato; Y Nakayama; Y Makino; Morimasa Wada; A T Fojo; Michihiko Kuwano
Cellular control of human multidrug resistance 1 (mdr-1) gene expression in absence and presence of gene amplification in human cancer cells.
The Journal of biological chemistry 1994;269(32):20503-8.
1994: T Abe; T Mori; K Kohno; Motoharu Seiki; T Hayakawa; H G Welgus; S Hori; Michihiko Kuwano
Expression of 72 kDa type IV collagenase and invasion activity of human glioma cells.
Clinical & experimental metastasis 1994;12(4):296-304.
1994: S Kotoh; S Naito; Akira Yokomizo; J Kumazawa; K Asakuno; Kimitoshi Kohno; Michihiko Kuwano
Increased expression of DNA topoisomerase I gene and collateral sensitivity to camptothecin in human cisplatin-resistant bladder cancer cells.
Cancer research 1994;54(12):3248-52.
1994: M Wada; S Hasegawa; K Kohno; Michihiko Kuwano
[Multidrug resistance (MDR)].
Gan to kagaku ryoho. Cancer & chemotherapy 1994;21(7):936-44.
1994: Morimasa Wada; Y Ihara; M Tatsuka; H Mitsui; Kimitoshi Kohno; Michihiko Kuwano; David Schlessinger
HPRT yeast artificial chromosome transfer into human cells by four methods and an involvement of homologous recombination.
Biochemical and biophysical research communications 1994;200(3):1693-700.
1994: Morimasa Wada; K Abe; Koji Okumura; H Taguchi; Kimitoshi Kohno; F Imamoto; David Schlessinger; Michihiko Kuwano
Chimeric YACs were generated at unreduced rates in conditions that suppress coligation.
Nucleic acids research 1994;22(9):1651-4.
1994: R Fujii; M Mutoh; K Niwa; Katsushi Yamada; Takashi Aikou; M Nakagawa; Michihiko Kuwano; S Akiyama
Active efflux system for cisplatin in cisplatin-resistant human KB cells.
Japanese journal of cancer research : Gann 1994;85(4):426-33.
1994: K Asakuno; Kimitoshi Kohno; T Uchiumi; T Kubo; S Sato; M Isono; Michihiko Kuwano
Involvement of a DNA binding protein, MDR-NF1/YB-1, in human MDR1 gene expression by actinomycin D.
Biochemical and biophysical research communications 1994;199(3):1428-35.
1994: A Morimoto; K Tada; Y Nakayama; Kimitoshi Kohno; S Naito; M Ono; Michihiko Kuwano
Cooperative roles of hepatocyte growth factor and plasminogen activator in tubular morphogenesis by human microvascular endothelial cells.
Japanese journal of cancer research : Gann 1994;85(1):53-62.
1993: K Ito; T Abe; M Tomita; A Morimoto; Kimitoshi Kohno; T Mori; Mayumi Ono; A Sugenoya; T Nishihira; Michihiko Kuwano
Anti-angiogenic activity of arachidonic acid metabolism inhibitors in angiogenesis model systems involving human microvascular endothelial cells and neovascularization in mice.
International journal of cancer. Journal international du cancer 1993;55(4):660-6.
1993: Kimitoshi Kohno; R Hamanaka; T Abe; Y Nomura; A Morimoto; H Izumi; K Shimizu; M Ono; Michihiko Kuwano
Morphological change and destabilization of beta-actin mRNA by tumor necrosis factor in human microvascular endothelial cells.
Experimental cell research 1993;208(2):498-503.
1993: T Okimoto; T Seguchi; Mayumi Ono; Y Nakayama; G Funatsu; T Fujiwara; Y Ikehara; Michihiko Kuwano
Brefeldin A protects ricin-induced cytotoxicity in human cancer KB cell line, but not in its resistant counterpart with altered Golgi structures.
Cell structure and function 1993;18(4):241-51.
1993: S Sato; Kimitoshi Kohno; K Hidaka; T Hisatsugu; Michihiko Kuwano; S Komiyama
Differentially potentiating effects by dipyridamole on cytotoxicity of 5-fluorouracil against three human maxillary cancer cell lines derived from a single tumor.
Anti-cancer drug design 1993;8(4):289-97.
1993: T Uchiumi; Kimitoshi Kohno; H Tanimura; K Hidaka; K Asakuno; H Abe; Y Uchida; Michihiko Kuwano
Involvement of protein kinase in environmental stress-induced activation of human multidrug resistance 1 (MDR1) gene promoter.
FEBS letters 1993;326(1-3):11-6.
1993: T Abe; K Okamura; M Ono; Kimitoshi Kohno; T Mori; S Hori; Michihiko Kuwano
Induction of vascular endothelial tubular morphogenesis by human glioma cells. A model system for tumor angiogenesis.
The Journal of clinical investigation 1993;92(1):54-61.
1993: T Uchiumi; Kimitoshi Kohno; H Tanimura; K Matsuo; S Sato; Y Uchida; Michihiko Kuwano
Enhanced expression of the human multidrug resistance 1 gene in response to UV light irradiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(3):147-57.
1993: K Matsuo; Kimitoshi Kohno; S Sato; T Uchiumi; H Tanimura; Y Yamada; Michihiko Kuwano
Enhanced expression of the DNA topoisomerase II gene in response to heat shock stress in human epidermoid cancer KB cells.
Cancer research 1993;53(5):1085-90.
1993: Y Sato; K Okamura; A Morimoto; R Hamanaka; K Hamaguchi; T Shimada; M Ono; Kimitoshi Kohno; T Sakata; Michihiko Kuwano
Indispensable role of tissue-type plasminogen activator in growth factor-dependent tube formation of human microvascular endothelial cells in vitro.
Experimental cell research 1993;204(2):223-9.
1992: M Ono; K Okamura; Y Nakayama; M Tomita; Y Sato; Y Komatsu; Michihiko Kuwano
Induction of human microvascular endothelial tubular morphogenesis by human keratinocytes: involvement of transforming growth factor-alpha.
Biochemical and biophysical research communications 1992;189(2):601-9.
1992: M Ono; Y Nakayama; G Princler; Jacob Gopas; H F Kung; Michihiko Kuwano
Polyoma middle T antigen or v-src desensitizes human epidermal growth factor receptor function and interference by a monensin-resistant mutation in mouse Balb/3T3 cells.
Experimental cell research 1992;203(2):456-65.
1992: M Miyazaki; Kimitoshi Kohno; T Uchiumi; H Tanimura; K Matsuo; M Nasu; Michihiko Kuwano
Activation of human multidrug resistance-1 gene promoter in response to heat shock stress.
Biochemical and biophysical research communications 1992;187(2):677-84.
1992: K Okamura; A Morimoto; R Hamanaka; M Ono; Kimitoshi Kohno; Y Uchida; Michihiko Kuwano
A model system for tumor angiogenesis: involvement of transforming growth factor-alpha in tube formation of human microvascular endothelial cells induced by esophageal cancer cells.
Biochemical and biophysical research communications 1992;186(3):1471-9.
1992: H Takano; Kimitoshi Kohno; K Matsuo; T Matsuda; Michihiko Kuwano
DNA topoisomerase-targeting antitumor agents and drug resistance.
Anti-cancer drugs 1992;3(4):323-30.
1992: R Hamanaka; Kimitoshi Kohno; T Seguchi; K Okamura; A Morimoto; M Ono; J Ogata; Michihiko Kuwano
Induction of low density lipoprotein receptor and a transcription factor SP-1 by tumor necrosis factor in human microvascular endothelial cells.
The Journal of biological chemistry 1992;267(19):13160-5.
1992: T Seguchi; Y Goto; M Ono; T Fujiwara; T Shimada; H F Kung; M Nishioka; Y Ikehara; Michihiko Kuwano
Brefeldin A-resistant mutants of human epidermoid carcinoma cell line with structural changes of the Golgi apparatus.
The Journal of biological chemistry 1992;267(16):11626-30.
1992: H Tanimura; Kimitoshi Kohno; S Sato; T Uchiumi; M Miyazaki; M Kobayashi; Michihiko Kuwano
The human multidrug resistance 1 promoter has an element that responds to serum starvation.
Biochemical and biophysical research communications 1992;183(2):917-24.
1992: T Matsuda; K Okamura; Y Sato; A Morimoto; M Ono; K Kohno; Michihiko Kuwano
Decreased response to epidermal growth factor during cellular senescence in cultured human microvascular endothelial cells.
Journal of cellular physiology 1992;150(3):510-6.
1991: R Hamanaka; T Seguchi; Y Sato; M Ono; Kimitoshi Kohno; Michihiko Kuwano
Rapid turnover of low density lipoprotein receptor in human monocytic THP-1 cells.
FEBS letters 1991;294(3):261-3.
1991: K Okamura; Y Sato; T Matsuda; R Hamanaka; M Ono; Kimitoshi Kohno; Michihiko Kuwano
Endogenous basic fibroblast growth factor-dependent induction of collagenase and interleukin-6 in tumor necrosis factor-treated human microvascular endothelial cells.
The Journal of biological chemistry 1991;266(29):19162-5.
1991: A Morimoto; K Okamura; R Hamanaka; Y Sato; Nobuyuki Shima; Kanji Higashio; Michihiko Kuwano
Hepatocyte growth factor modulates migration and proliferation of human microvascular endothelial cells in culture.
Biochemical and biophysical research communications 1991;179(2):1042-9.
1991: A Kiue; T Sano; A Naito; M Okumura; Kimitoshi Kohno; Michihiko Kuwano
Enhancement of antitumour activity of etoposide by dihydropyridines on drug-sensitive and drug-resistant leukaemia in mice.
British journal of cancer 1991;64(2):221-6.
1991: H Takano; Kimitoshi Kohno; M Ono; Y Uchida; Michihiko Kuwano
Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells.
Cancer research 1991;51(15):3951-7.
1991: M Ono; Michihiko Kuwano; H F Kung
Malignant transformation of mouse BALB/3T3 cells by polyoma middle T antigen requires epidermal growth factor receptor expression.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(7):317-22.
1991: Y Watanabe; H Takano; A Kiue; Kimitoshi Kohno; Michihiko Kuwano
Potentiation of etoposide and vincristine by two synthetic 1,4-dihydropyridine derivatives in multidrug-resistant and atypical multidrug-resistant human cancer cells.
Anti-cancer drug design 1991;6(1):47-57.
1991: Michihiko Kuwano; T Seguchi; M Ono
Glycosylation mutations of serine/threonine-linked oligosaccharides in low-density lipoprotein receptor: indispensable roles of O-glycosylation.
Journal of cell science 1991;98 ( Pt 2)():131-4.
1991: T Seguchi; R K Merkle; M Ono; Michihiko Kuwano; Richard D Cummings
The dysfunctional LDL receptor in a monensin-resistant mutant of Chinese hamster ovary cells lacks selected O-linked oligosaccharides.
Archives of biochemistry and biophysics 1991;284(2):245-56.
1991: M Mawatari; K Okamura; T Matsuda; R Hamanaka; H Mizoguchi; Kanji Higashio; Kimitoshi Kohno; Michihiko Kuwano
Tumor necrosis factor and epidermal growth factor modulate migration of human microvascular endothelial cells and production of tissue-type plasminogen activator and its inhibitor.
Experimental cell research 1991;192(2):574-80.
1991: T Uchiumi; H Mizoguchi; Y Hagino; Kimitoshi Kohno; Michihiko Kuwano
Counteraction of estradiol-induced activation of tissue-type plasminogen activator in a human breast cancer cell line by an anti-estrogen, LY117018.
International journal of cancer. Journal international du cancer 1991;47(1):80-5.
1991: A Nakagawara; K Kadomatsu; S Sato; Kimitoshi Kohno; H Takano; Michihiko Kuwano
Inverse expression of MYCN and mdr-1 in human neuroblastoma.
Progress in clinical and biological research 1991;366():11-9.
1990: Kimitoshi Kohno; S Sato; T Uchiumi; H Takano; S Kato; Michihiko Kuwano
Tissue-specific enhancer of the human multidrug-resistance (MDR1) gene.
The Journal of biological chemistry 1990;265(32):19690-6.
1990: S Shite; T Seguchi; H Mizoguchi; M Ono; Michihiko Kuwano
Differential effects of brefeldin A on sialylation of N- and O-linked oligosaccharides in low density lipoprotein receptor and epidermal growth factor receptor.
The Journal of biological chemistry 1990;265(29):17385-8.
1990: K Matsuo; Kimitoshi Kohno; H Takano; S Sato; A Kiue; Michihiko Kuwano
Reduction of drug accumulation and DNA topoisomerase II activity in acquired teniposide-resistant human cancer KB cell lines.
Cancer research 1990;50(18):5819-24.
1990: S Shite; T Seguchi; T Shimada; M Ono; Michihiko Kuwano
Rapid turnover of low-density lipoprotein receptor by a non-lysosomal pathway in mouse macrophage J774 cells and inhibitory effect of brefeldin A.
European journal of biochemistry / FEBS 1990;191(2):491-7.
1990: H Mizoguchi; T Uchiumi; M Ono; Kimitoshi Kohno; Michihiko Kuwano
Enhanced production of tissue-type plasminogen activator by estradiol in a novel type variant of human breast cancer MCF-7 cell line.
Biochimica et biophysica acta 1990;1052(3):475-82.
1990: A Nakagawara; K Kadomatsu; S Sato; Kimitoshi Kohno; H Takano; K Akazawa; Y Nose; Michihiko Kuwano
Inverse correlation between expression of multidrug resistance gene and N-myc oncogene in human neuroblastomas.
Cancer research 1990;50(10):3043-7.
1990: M Miyazaki; Kimitoshi Kohno; Y Saburi; K Matsuo; M Ono; Michihiko Kuwano; S Tsuchida; K Sato; M Sakai; M Muramatsu
Drug resistance to cis-diamminedichloroplatinum (II) in Chinese hamster ovary cell lines transfected with glutathione S-transferase pi gene.
Biochemical and biophysical research communications 1990;166(3):1358-64.
1990: A Kiue; T Sano; K Suzuki; H Inada; M Okumura; J Kikuchi; S Sato; Kimitoshi Kohno; Michihiko Kuwano
Activities of newly synthesized dihydropyridines in overcoming of vincristine resistance, calcium antagonism, and inhibition of photoaffinity labeling of P-glycoprotein in rodents.
Cancer research 1990;50(2):310-7.
1990: R Hamanaka; M Ono; Y Kuratomi; H Mizoguchi; R Hirai; Kimitoshi Kohno; Michihiko Kuwano
Epidermal growth factor (EGF)-nonresponsive variants of normal rat kidney cell line: response to EGF and transforming growth factor-beta.
Experimental cell research 1990;186(1):83-9.
1989: Kimitoshi Kohno; S Sato; H Takano; K Matsuo; Michihiko Kuwano
The direct activation of human multidrug resistance gene (MDR1) by anticancer agents.
Biochemical and biophysical research communications 1989;165(3):1415-21.
1989: Y Saburi; M Nakagawa; M Ono; M Sakai; M Muramatsu; Kimitoshi Kohno; Michihiko Kuwano
Increased expression of glutathione S-transferase gene in cis-diamminedichloroplatinum(II)-resistant variants of a Chinese hamster ovary cell line.
Cancer research 1989;49(24 Pt 1):7020-5.
1989: S Akiyama; A Yoshimura; H Kikuchi; Tomoyuki Sumizawa; Michihiko Kuwano; Y Tahara
Synthetic isoprenoid photoaffinity labeling of P-glycoprotein specific to multidrug-resistant cells.
Molecular pharmacology 1989;36(5):730-5.
1989: Michihiko Kuwano; M Ono
Somatic cell mutants of low density lipoprotein receptor.
Cell structure and function 1989;14(5):501-7.
1989: M Mawatari; Kimitoshi Kohno; H Mizoguchi; T Matsuda; K Asoh; J Van Damme; H G Welgus; Michihiko Kuwano
Effects of tumor necrosis factor and epidermal growth factor on cell morphology, cell surface receptors, and the production of tissue inhibitor of metalloproteinases and IL-6 in human microvascular endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(5):1619-27.
1989: S Sato; Y Watanabe; K Okamura; R Hamanaka; T Mori; Kimitoshi Kohno; Michihiko Kuwano
Potentiation of vincristine and actinomycin D by a new synthetic imidazole anti-tumor agent YM534 active against human cancer cells and multidrug-resistant cells.
Anti-cancer drug design 1989;4(2):125-35.
1989: K Asoh; Y Watanabe; H Mizoguchi; M Mawatari; M Ono; Kimitoshi Kohno; Michihiko Kuwano
Induction of manganese superoxide dismutase by tumor necrosis factor in human breast cancer MCF-7 cell line and its TNF-resistant variant.
Biochemical and biophysical research communications 1989;162(2):794-801.
1989: T Seguchi; A Yoshimura; M Ono; S Shite; M Kasahara; Y Ebina; W J Rutter; Michihiko Kuwano
Insulin receptor and altered glucose transport in a monensin-resistant mutant of Chinese hamster ovary cell.
Journal of cellular physiology 1989;139(2):229-36.
1989: K Asoh; Y Saburi; S Sato; I Nogae; Kimitoshi Kohno; Michihiko Kuwano
Potentiation of some anticancer agents by dipyridamole against drug-sensitive and drug-resistant cancer cell lines.
Japanese journal of cancer research : Gann 1989;80(5):475-81.
1989: H Takano; Kimitoshi Kohno; N Shiraishi; S Sato; K Asoh; M Yakushiniji; M Ono; Michihiko Kuwano
Altered expression of epidermal growth factor receptor gene in a classical multidrug-resistant variant of a human cancer cell line, KB.
Japanese journal of cancer research : Gann 1989;80(4):373-9.
1989: Sohtaro Komiyama; K Matsui; S Kudoh; I Nogae; Y Kuratomi; Y Saburi; K Asoh; Kimitoshi Kohno; Michihiko Kuwano
Establishment of tumor cell lines from a patient with head and neck cancer and their different sensitivities to anti-cancer agents.
Cancer 1989;63(4):675-81.
1989: I Nogae; Kimitoshi Kohno; J Kikuchi; Michihiko Kuwano; S Akiyama; A Kiue; K Suzuki; Y Yoshida; M M Cornwell; Ira Pastan
Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein.
Biochemical pharmacology 1989;38(3):519-27.
1988: S Shite; T Seguchi; T Yoshida; Kimitoshi Kohno; M Ono; Michihiko Kuwano
A new class mutation of low density lipoprotein receptor with altered carbohydrate chains.
The Journal of biological chemistry 1988;263(36):19286-9.
1988: Kimitoshi Kohno; J Kikuchi; S Sato; H Takano; Y Saburi; K Asoh; Michihiko Kuwano
Vincristine-resistant human cancer KB cell line and increased expression of multidrug-resistance gene.
Japanese journal of cancer research : Gann 1988;79(11):1238-46.
1988: M Ono; M Yakushinji; K Segawa; Michihiko Kuwano
Transformation by viral and cellular oncogenes of a mouse BALB/3T3 cell mutant resistant to transformation by chemical carcinogens.
Molecular and cellular biology 1988;8(10):4190-6.
1988: A Yoshimura; T Seguchi; T Yoshida; S Shite; M Waki; Michihiko Kuwano
Novel feature of metabolism of low density lipoprotein receptor in a mouse macrophage-like cell line, J774.1.
The Journal of biological chemistry 1988;263(24):11935-42.
1988: N Shiraishi; T Shimada; Y Hagino; Kimitoshi Kohno; M Kobayashi; Michihiko Kuwano; S Akiyama
Potentiation by a biscoclaurine alkaloid, cepharanthine, of the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin in HeLa cells.
Cancer research 1988;48(5):1307-11.
1988: S Akiyama; M M Cornwell; Michihiko Kuwano; Ira Pastan; Michael M Gottesman
Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.
Molecular pharmacology 1988;33(2):144-7.
1988: Y Hagino; M Mawatari; A Yoshimura; Kimitoshi Kohno; M Kobayashi; Michihiko Kuwano
Estrogen inhibits the growth of MCF-7 cell variants resistant to transforming growth factor-beta.
Japanese journal of cancer research : Gann 1988;79(1):74-81.
1987: A Yoshimura; T Kobayashi; K Hidaka; Michihiko Kuwano; S Ohnishi
Altered interaction between Sendai virus and a Chinese hamster cell mutant with defective cholesterol synthesis.
Biochimica et biophysica acta 1987;904(1):159-64.
1987: T Yoshida; A Yoshimura; M Ono; S Hori; M Waki; Michihiko Kuwano
Altered function and structure of low-density lipoprotein receptor in compactin (ML236B)-resistant mutants of Chinese hamster cells.
Biochimica et biophysica acta 1987;921(3):575-86.
1987: A Yoshimura; T Yoshida; T Seguchi; M Waki; M Ono; Michihiko Kuwano
Low binding capacity and altered O-linked glycosylation of low density lipoprotein receptor in a monensin-resistant mutant of Chinese hamster ovary cells.
The Journal of biological chemistry 1987;262(27):13299-308.
1987: I Nogae; J Kikuchi; T Yamaguchi; M Nakagawa; N Shiraishi; Michihiko Kuwano
Potentiation of vincristine by vitamin A against drug-resistant mouse leukaemia cells.
British journal of cancer 1987;56(3):267-72.
1982: M Ono; Michihiko Kuwano; K Watanabe; G Funatsu
Chinese hamster cell variants resistant to the A chain of ricin carry altered ribosome function.
Molecular and cellular biology 1982;2(6):599-606.
1969: Michihiko Kuwano; H Endo
Phenotypic suppression by streptomycin of amber mutants in the ribonucleic Acid bacteriophage coat protein cistron.
Journal of virology 1969;4(3):252-5.