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Jan-Olov Kvassman

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Lorena Gonzalez Palmén; Jan-Olov Kvassman
Differential inhibition of homotrimeric dUTPases by the 3'-azido derivative of dideoxy-UTP.
Lorena González Palmén; Kristian Becker; Leif Bülow; Jan-Olov Kvassman
A double role for a strictly conserved serine: further insights into the dUTPase catalytic mechanism.
GRant Blouse; Michel J Perron; Jan-Olov Kvassman; Saadia Yunus; Jannah H Thompson; Russell Betts; Leonard C Lutter; Joseph D Shore
Mutation of the highly conserved tryptophan in the serpin breach region alters the inhibitory mechanism of plasminogen activator inhibitor-1.

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All Publications

2010: Lorena Gonzalez Palmén; Jan-Olov Kvassman
Differential inhibition of homotrimeric dUTPases by the 3'-azido derivative of dideoxy-UTP.
Journal of enzyme inhibition and medicinal chemistry 2010;25(1):146-50.
2008: Lorena González Palmén; Kristian Becker; Leif Bülow; Jan-Olov Kvassman
A double role for a strictly conserved serine: further insights into the dUTPase catalytic mechanism.
Biochemistry 2008;47(30):7863-74.
2003: GRant Blouse; Michel J Perron; Jan-Olov Kvassman; Saadia Yunus; Jannah H Thompson; Russell Betts; Leonard C Lutter; Joseph D Shore
Mutation of the highly conserved tryptophan in the serpin breach region alters the inhibitory mechanism of plasminogen activator inhibitor-1.
Biochemistry 2003;42(42):12260-72.
2001: Steven T Olson; Richard Swanson; D Day; Ingrid Verhamme; Jan-Olov Kvassman; Joseph D Shore
Resolution of Michaelis complex, acylation, and conformational change steps in the reactions of the serpin, plasminogen activator inhibitor-1, with tissue plasminogen activator and trypsin.
Biochemistry 2001;40(39):11742-56.
2000: Daniel Lawrence; Steven T Olson; S Muhammad; Duane E Day; Jan-Olov Kvassman; David Ginsburg; Joseph D Shore
Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.
The Journal of biological chemistry 2000;275(8):5839-44.
1999: Ingrid Verhamme; Jan-Olov Kvassman; D Day; Sophie Debrock; Nele Vleugels; Paul J Declerck; Joseph D Shore
Accelerated conversion of human plasminogen activator inhibitor-1 to its latent form by antibody binding.
The Journal of biological chemistry 1999;274(25):17511-7.
1998: Jan-Olov Kvassman; Ingrid Verhamme; Joseph D Shore
Inhibitory mechanism of serpins: loop insertion forces acylation of plasminogen activator by plasminogen activator inhibitor-1.
Biochemistry 1998;37(44):15491-502.
1995: Steven T Olson; Paul E Bock; Jan-Olov Kvassman; Joseph D Shore; Daniel Lawrence; David Ginsburg; Ingemar Björk
Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes.
The Journal of biological chemistry 1995;270(50):30007-17.
1995: Jan-Olov Kvassman; Daniel Lawrence; Joseph D Shore
The acid stabilization of plasminogen activator inhibitor-1 depends on protonation of a single group that affects loop insertion into beta-sheet A.
The Journal of biological chemistry 1995;270(46):27942-7.
1995: Daniel Lawrence; David Ginsburg; D E Day; M B Berkenpas; Ingrid Verhamme; Jan-Olov Kvassman; Joseph D Shore
Serpin-protease complexes are trapped as stable acyl-enzyme intermediates.
The Journal of biological chemistry 1995;270(43):25309-12.
1995: Joseph D Shore; D E Day; A M Francis-Chmura; Ingrid Verhamme; Jan-Olov Kvassman; Daniel Lawrence; David Ginsburg
A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism.
The Journal of biological chemistry 1995;270(10):5395-8.