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Linda Kwong

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John L Robinson; Anna Stieber; Felix Geser; Linda K Kwong; Virginia M-Y Lee; Mfon Umoh; Vivianna M Van Deerlin; John Q Trojanowski
TDP-43 skeins show properties of amyloid in a subset of ALS cases.
Alice S Chen-Plotkin; Michael D Gallagher; Murray Grossman; Linda K Kwong; John Q Trojanowski; Travis L Unger; Vivianna M Van Deerlin; Laura Volpicelli-Daley; Sebastian Akle; Emily Bill; Johanna I Busch; Virginia M-Y Lee
TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.
Johannes Brettschneider; Lauren B Elman; Murray Grossman; David J Irwin; Linda K Kwong; Edward B Lee; Virginia M-Y Lee; Leo McCluskey; Laura Molina-Porcel; Mervyn Monteiro; John L Robinson; Nathaniel Safren; Jon B Toledo; Yousuf O Ali; Vivianna M Van Deerlin; John Q Trojanowski
Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.

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All Publications

2013: John L Robinson; Anna Stieber; Felix Geser; Linda K Kwong; Virginia M-Y Lee; Mfon Umoh; Vivianna M Van Deerlin; John Q Trojanowski
TDP-43 skeins show properties of amyloid in a subset of ALS cases.
Acta neuropathologica 2013;125(1):121-31.
2012: Alice S Chen-Plotkin; Michael D Gallagher; Murray Grossman; Linda K Kwong; John Q Trojanowski; Travis L Unger; Vivianna M Van Deerlin; Laura Volpicelli-Daley; Sebastian Akle; Emily Bill; Johanna I Busch; Virginia M-Y Lee
TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(33):11213-27.
2012: Johannes Brettschneider; Lauren B Elman; Murray Grossman; David J Irwin; Linda K Kwong; Edward B Lee; Virginia M-Y Lee; Leo McCluskey; Laura Molina-Porcel; Mervyn Monteiro; John L Robinson; Nathaniel Safren; Jon B Toledo; Yousuf O Ali; Vivianna M Van Deerlin; John Q Trojanowski
Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.
Acta neuropathologica 2012;123(6):825-39.
2011: Felix Geser; Beth Stein; Michael Partain; Lauren B Elman; Leo McCluskey; Sharon X Xie; Vivianna M Van Deerlin; Linda K Kwong; Virginia M-Y Lee; John Q Trojanowski
Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy.
Acta neuropathologica 2011;121(4):509-17.
2011: Todd J Cohen; Jing L Guo; David E Hurtado; Linda K Kwong; Ian P Mills; John Q Trojanowski; Virginia M-Y Lee
The acetylation of tau inhibits its function and promotes pathological tau aggregation.
Nature communications 2011;2():252.
2010: Felix Geser; John L Robinson; Joseph A Malunda; Sharon X Xie; Chris M Clark; Linda K Kwong; Paul J Moberg; Erika M Moore; Vivianna M Van Deerlin; Virginia M-Y Lee; Steven E Arnold; John Q Trojanowski
Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness.
Archives of neurology 2010;67(10):1238-50.
2009: Felix Geser; Maria Martinez-Lage; Linda K Kwong; Virginia M-Y Lee; John Q Trojanowski
Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases.
Journal of neurology 2009;256(8):1205-14.
2009: Lionel M Igaz; Linda K Kwong; Alice Chen-Plotkin; Matthew J Winton; Travis L Unger; Yan Xu; Manuela Neumann; John Q Trojanowski; Virginia M-Y Lee
Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.
The Journal of biological chemistry 2009;284(13):8516-24.
2009: Felix Geser; Maria Martinez-Lage; John Robinson; Kunihiro Uryu; Manuela Neumann; Nicholas J Brandmeir; Sharon X Xie; Linda K Kwong; Lauren B Elman; Leo McCluskey; Chris M Clark; Joe Malunda; Bruce L Miller; Earl A Zimmerman; Jiang Qian; Vivianna M Van Deerlin; Murray Grossman; Virginia M-Y Lee; John Q Trojanowski
Clinical and pathological continuum of multisystem TDP-43 proteinopathies.
Archives of neurology 2009;66(2):180-9.
2008: Lionel M Igaz; Linda K Kwong; Yan Xu; Adam C Truax; Kunihiro Uryu; Manuela Neumann; Christopher M Clark; Lauren B Elman; Bruce L Miller; Murray Grossman; Leo McCluskey; John Q Trojanowski; Virginia M-Y Lee
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
The American journal of pathology 2008;173(1):182-94.
2008: Matthew J Winton; Vivianna M Van Deerlin; Linda K Kwong; Wuxing Yuan; Elisabeth McCarty Wood; Chang-En Yu; Gerard D Schellenberg; Rosa Rademakers; Richard Caselli; Anna Karydas; John Q Trojanowski; Bruce L Miller; Virginia M-Y Lee
A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro.
FEBS letters 2008;582(15):2252-6.
2008: Kunihiro Uryu; Hanae Nakashima-Yasuda; Mark S Forman; Linda K Kwong; Christopher M Clark; Murray Grossman; Bruce L Miller; Hans A Kretzschmar; Virginia M-Y Lee; John Q Trojanowski; Manuela Neumann
Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies.
Journal of neuropathology and experimental neurology 2008;67(6):555-64.
2008: Alice S Chen-Plotkin; Felix Geser; Joshua B Plotkin; Christopher M Clark; Linda K Kwong; Wuxing Yuan; Murray Grossman; Vivianna M Van Deerlin; John Q Trojanowski; Virginia M-Y Lee
Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration.
Human molecular genetics 2008;17(10):1349-62.
2008: Matthew J Winton; Lionel M Igaz; Margaret M Wong; Linda K Kwong; John Q Trojanowski; Virginia M-Y Lee
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.
The Journal of biological chemistry 2008;283(19):13302-9.
2008: Felix Geser; Nicholas J Brandmeir; Linda K Kwong; Maria Martinez-Lage; Lauren B Elman; Leo McCluskey; Sharon X Xie; Virginia M-Y Lee; John Q Trojanowski
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis.
Archives of neurology 2008;65(5):636-41.
2008: Linda K Kwong; Kunihiro Uryu; John Q Trojanowski; Virginia M-Y Lee
TDP-43 proteinopathies: neurodegenerative protein misfolding diseases without amyloidosis.
Neuro-Signals 2008;16(1):41-51.
2008: Nicholas J Brandmeir; Felix Geser; Linda K Kwong; Earl Zimmerman; Jiang Qian; Virginia M-Y Lee; John Q Trojanowski
Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease.
Acta neuropathologica 2008;115(1):123-31.
2008: Felix Geser; Matthew J Winton; Linda K Kwong; Yan Xu; Sharon X Xie; Lionel M Igaz; Ralph M Garruto; Daniel P Perl; Douglas Galasko; Virginia M-Y Lee; John Q Trojanowski
Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.
Acta neuropathologica 2008;115(1):133-45.
2007: Murray Grossman; Elisabeth M Wood; Peachie Moore; Manuela Neumann; Linda K Kwong; Mark S Forman; Christopher M Clark; Leo McCluskey; Bruce L Miller; Virginia M-Y Lee; John Q Trojanowski
TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Archives of neurology 2007;64(10):1449-54.
2007: Manuela Neumann; Linda K Kwong; Deepak M Sampathu; John Q Trojanowski; Virginia M-Y Lee
TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis.
Archives of neurology 2007;64(10):1388-94.
2007: Vivianna M Van Deerlin; Elisabeth McCarty Wood; Peachie Moore; Wuxing Yuan; Mark S Forman; Christopher M Clark; Manuela Neumann; Linda K Kwong; John Q Trojanowski; Virginia M-Y Lee; Murray Grossman
Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations.
Archives of neurology 2007;64(8):1148-53.
2007: Nigel J Cairns; Manuela Neumann; Eileen H Bigio; Ida E Holm; Dirk Troost; Kimmo J Hatanpaa; Chan Foong; Charles L White; Julie A Schneider; Hans A Kretzschmar; Deborah Carter; Lisa Taylor-Reinwald; Katherine Paulsmeyer; Jeffrey Strider; Michael Gitcho; Alison Goate; John C Morris; Manjari Mishra; Linda K Kwong; Anna Stieber; Yan Xu; Mark S Forman; John Q Trojanowski; Virginia M-Y Lee; Ian R A Mackenzie
TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.
The American journal of pathology 2007;171(1):227-40.
2007: Linda K Kwong; Manuela Neumann; Deepak M Sampathu; Virginia M-Y Lee; John Q Trojanowski
TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease.
Acta neuropathologica 2007;114(1):63-70.
2007: Ian R A Mackenzie; Eileen H Bigio; Paul Geoffrey Ince; Felix Geser; Manuela Neumann; Nigel J Cairns; Linda K Kwong; Mark S Forman; John Ravits; Heather Stewart; Andrew Eisen; Leo McClusky; Hans A Kretzschmar; Camelia M Monoranu; J Robin Highley; Janine Kirby; Teepu Siddique; Pamela J Shaw; Virginia M-Y Lee; John Q Trojanowski
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
Annals of neurology 2007;61(5):427-34.
2007: Manuela Neumann; Lionel Igaz; Linda K Kwong; Hanae Nakashima-Yasuda; Stephen J Kolb; Gideon Dreyfuss; Hans A Kretzschmar; John Q Trojanowski; Virginia M-Y Lee
Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.
Acta neuropathologica 2007;113(5):543-8.
2007: Manuela Neumann; Linda K Kwong; Adam C Truax; Ben Vanmassenhove; Hans A Kretzschmar; Vivianna M Van Deerlin; Christopher M Clark; Murray Grossman; Bruce L Miller; John Q Trojanowski; Virginia M-Y Lee
TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Journal of neuropathology and experimental neurology 2007;66(3):177-83.
2006: Manuela Neumann; Deepak M Sampathu; Linda K Kwong; Adam C Truax; Matthew Micsenyi; Thomas T Chou; Jennifer Bruce; Theresa Schuck; Murray Grossman; Christopher M Clark; Leo McCluskey; Bruce L Miller; Eliezer Masliah; Ian R A Mackenzie; Howard Feldman; Wolfgang Feiden; Hans A Kretzschmar; John Q Trojanowski; Virginia M-Y Lee
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science (New York, N.Y.) 2006;314(5796):130-3.
2006: Deepak M Sampathu; Manuela Neumann; Linda K Kwong; Thomas T Chou; Matthew Micsenyi; Adam C Truax; Jennifer Bruce; Murray Grossman; John Q Trojanowski; Virginia M-Y Lee
Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies.
The American journal of pathology 2006;169(4):1343-52.
2006: Edward B Lee; Lewis Z Leng; Bin Zhang; Linda K Kwong; John Q Trojanowski; Ted Abel; Virginia M-Y Lee
Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.
The Journal of biological chemistry 2006;281(7):4292-9.